[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Uludag University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":632},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,24,0,[8,46,83,108,138,162,186,221,247,267,297,328,356,383,405,427,459,479,494,513,541,566,585,611],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100645186","consent-understanding-and-propofol-requirement-during-endobronchial-ultrasound-100645186",false,"NCT07677982","Consent Understanding and Propofol Requirement During Endobronchial Ultrasound","Association of Preoperative Consent Understanding With Propofol Requirement During Endobronchial Ultrasound: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective endobronchial ultrasound\n* ASA physical status I to III\n* Ability to read and understand Turkish\n* Provision of written informed consent for study participation\n\nExclusion Criteria:\n\n* Active psychiatric disease that may affect the informed consent process, anxiety assessment, or communication\n* Cognitive impairment, including dementia or delirium\n* Contraindication or known allergy to propofol, midazolam, or remifentanil\n* Emergency EBUS procedure\n* Regular anxiolytic or sedative drug use within the last month\n* Illiteracy\n* Turkish language barrier\n* Advanced organ failure or decompensated systemic disease that may significantly affect sedative drug response, hemodynamic stability, communication, or consent assessment","ALL","18 Years",{"count":19,"type":20},75,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether a participant's understanding of the informed consent information is related to the amount of propofol needed during endobronchial ultrasound (EBUS). EBUS is a procedure that uses a thin camera and ultrasound to look at lymph nodes and other areas inside the chest. Propofol is a sedative medicine used to help participants stay comfortable during the procedure.\n\nBefore EBUS, all participants will receive the usual information about the procedure as part of routine care. After this routine consent process, participants will answer short questions about what they understood. They will also answer questions about their anxiety before the procedure. The study will not change the usual consent process, sedation plan, or medical care.\n\nDuring EBUS, participants will receive usual sedation and monitoring according to routine clinical practice. The research team will record how much sedative medicine is used, whether extra sedation is needed, whether any important clinical events occur, and how participants recover after sedation. The main question is whether participants who understand the consent information better need less propofol during EBUS.",[24,25,26],"ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION","Procedural Sedation and Analgesia","Informed Consent",[28,29,30,31,32,33],"EBUS-TBNA","Informed consent understanding","Procedural sedation","Preoperative anxiety","Sedative requirement","Propofol consumption","NOT_YET_RECRUITING","2026-06-30",{"date":37,"type":38},"2026-07-01","ACTUAL",{"date":37,"type":20},{"date":41,"type":20},"2027-07-01",{"name":43,"class":44},"Uludag University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":68,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":45},"100626821","lower-limb-muscle-mass-and-cardiovascular-and-muscular-performance-in-males-and-females-100626821","NCT07440615","Lower-Limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females","The Relationship Between Lower-limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females.","Inclusion Criteria:\n\n* absent of lower body injuries that could impact testing;\n* were moderately physically active\n* did not ingest ergogenic aids or stimulant drugs for at least 6 months prior to the start of the study.\n\nExclusion Criteria:\n\n\\-",true,"30 Years",{"count":56,"type":20},235,"INTERVENTIONAL",[59],"NA","The aim of this study will be to examine the relationship between leg muscle mass and muscle strength, aerobic capacity, anaerobic power, and jumping performance in young adults. In addition, these physical performance measures will be compared between male and female participants.\n\nRecreationally active young adults will be recruited to participate in the study. Body weight and leg muscle mass will be assessed using a body composition analyzer. Participants will perform isokinetic and isometric leg strength tests, an aerobic fitness test (VO₂max), an anaerobic power test (Wingate), and a countermovement jump (CMJ) test.\n\nThis study aims to improve the understanding of the effects of leg muscle mass on physical performance and to identify possible differences between males and females. The findings are expected to contribute to exercise prescription, performance assessment, and future research in sports and health sciences.",[62,63,64,65,66,67],"Physical Performance","Leg Muscle Mass","Muscle Strength","Aerobic Capacity","Anaerobic Power","Jumping Performance in Young Adults",[69,70,71,72,73],"lean mass","isokinetic","isometric","aerobic capacity","force","RECRUITING","2026-06-05",{"date":77,"type":38},"2026-06-09",{"date":79,"type":38},"2026-02-20",{"date":81,"type":20},"2026-08-15",{"name":43,"class":44},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":57,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100639026","standardized-patient-education-in-pituitary-surgery-100639026","NCT07618949","Standardized Patient Education in Pituitary Surgery","The Impact of Standardized Patient Education on Patient Outcomes in Transsphenoidal Pituitary Surgery","Inclusion Criteria:\n\n* Admitted for elective surgery due to a pituitary tumor.\n* Has not previously undergone surgery for the same medical condition.\n* Has voluntarily agreed to participate in the study.\n* Has no missing medical data.\n* Can speak Turkish or understand what is being explained.\n* Patients aged 18 and older.\n\nExclusion Criteria:\n\n* Emergency surgery will be performed.\n* Revision surgery will be performed.\n* Those who voluntarily decline to participate in the study.\n* Those with incomplete medical data.\n* Those who cannot speak or understand Turkish.\n* Patients under the age of 18.",{"count":91,"type":20},102,[59],"Protocols are being developed and implemented to ensure the best possible recovery process for patients undergoing transsphenoidal surgery, and their impact on patient outcomes is being evaluated. In studies where perioperative protocols-including patient education (verbal and written instruction on dehydration, hyponatremia, adrenal insufficiency, CSF leakage, meningitis, and the signs and symptoms of visual or other neurological disorders)-are implemented, it has been reported that patients' length of hospital stay is reduced, the rate of patients experiencing hyponatremia has decreased, and readmissions have declined (Sanchez-Garavito et al., 2024; Sarris et al., 2021). However, since these studies included protocols covering the entire surgical process-not just patient education-it is difficult to determine whether changes in patient outcomes stem from patient education or from alterations in other parameters within the protocol.\n\nTherefore, in the clinic where this study will be conducted, the effect of patient education on postoperative patient outcomes will be examined by developing an educational material that standardizes patient education, without making any changes to the surgical or pharmacological processes.",[95],"Pituitary Adenoma",[97,98,99],"Pituitary tumor","transsphenoidal surgery","Patient education","2026-05-24",{"date":102,"type":38},"2026-06-01",{"date":104,"type":20},"2026-06",{"date":106,"type":20},"2027-09",{"name":43,"class":44},{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":115,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":57,"phases":118,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":45},"100637074","home-based-exercise-programs-for-fall-prevention-in-parkinson-disease-100637074","NCT07590700","Home-Based Exercise Programs for Fall Prevention in Parkinson Disease","Effectiveness of Fall-Preventive Home Exercise Programs in Patients With Parkinson Disease: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of Parkinson disease confirmed by a neurologist\n* Hoehn and Yahr stage 3 or 4 Parkinson disease\n* Diagnosis of Parkinson disease for at least 5 years\n* Willingness to participate in the study and provide written informed consent\n* Ability to walk independently or with minimal assistance\n* Mini-Mental State Examination score \\>24\n\nExclusion Criteria:\n\n* Balance or gait impairment due to causes other than Parkinson disease, such as severe orthopedic problems or another neurological disease\n* Red flags suggestive of Parkinson-plus syndromes, such as symmetric onset, early falls, early-onset dementia, or gaze palsy\n* History of serious fall-related injury or surgery within the last 6 months\n* Any additional health condition that would prevent participation in the exercise program during the study period","40 Years",{"count":117,"type":20},30,[59],"Falls are common in patients with Parkinson disease and may lead to reduced mobility, fear of falling, loss of independence, and injury. Exercise-based rehabilitation programs may help improve balance, gait, and physical performance in this population.\n\nThis randomized controlled trial aims to compare the effectiveness of two home-based exercise programs in patients with Parkinson disease: the Otago Exercise Program and a structured home exercise program. Participants will be randomly assigned to one of two groups. Both groups will receive exercise education and will perform their assigned home exercise program for 6 weeks.\n\nParticipants will be evaluated at baseline, at week 3, and at the end of week 6. The study will assess fall-related outcomes, freezing of gait, functional mobility, gait parameters, postural control, and physical performance. The results may help determine which home-based exercise approach is more effective for reducing fall risk and improving functional outcomes in patients with Parkinson disease.",[121,122,123],"PARKINSON DISEASE (Disorder)","Falls Prevention","Exercise",[125,126,127,128,129],"parkinson disease","fall prevention","Otago","Home-based","Execise","2026-05-15",{"date":132,"type":38},"2026-05-19",{"date":134,"type":38},"2026-02-08",{"date":136,"type":20},"2026-08",{"name":43,"class":44},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":147,"conditions":148,"keywords":151,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":4},"100636958","the-relationship-between-nurses-perception-of-safety-culture-and-patients-sense-of-safety-100636958","NCT07572448","The Relationship Between Nurses' Perception Of Safety Culture And Patients' Sense Of Safety","An Investigation Of The Relationship Between Day Surgery Nurses' Perception Of Safety Culture And Patients' Level Of Feeling Safe During Surgery","Inclusion Criteria:\n\n* Currently working as a healthcare professional in an outpatient surgical unit,\n* No visual, auditory, or psychological impairments that would prevent them from completing the questionnaires and scales,\n* At least a graduate of a vocational high school for healthcare professions,\n* Patients scheduled for elective surgery under local anesthesia,\n* Patients and nurses who voluntarily agreed to participate in the study.\n\nExclusion Criteria:\n\n* Refusal to voluntarily participate in the study,\n* Presence of any visual, auditory, or psychological impairments that would prevent the completion of questionnaires and scales,\n* Individuals who are not healthcare professionals.\n* Patients undergoing emergency surgical procedures or those under general anesthesia.",{"count":146,"type":20},206,"This study will be conducted to determine the relationship between the perception of safety culture among healthcare professionals working in an outpatient surgical unit and the level of safety patients feel during surgery performed under local anesthesia.\n\nThe study population consists of healthcare professionals (N = 140) working in the Day Surgery Unit of Bursa Uludağ University Faculty of Medicine Hospital and patients undergoing procedures. The sample size calculation for the healthcare professionals to be included in the study was determined using the known population sampling method. Using the Raosoft sampling method, with a 5% margin of error and a 95% confidence interval, the minimum required sample size (n) was calculated to be 103. It was decided that the study would include healthcare professionals and patients in a 1:1 ratio. Therefore, the total sample size was calculated to be 206.\n\nData will be collected using the Hospital Survey on Patient Safety Culture (Version 2.0) and the Feeling Safe During Surgery Scale.",[149,150],"Nursing Personnel","Safety",[152,153],"Safety culture","Feeling safe","2026-05-06",{"date":156,"type":38},"2026-05-07",{"date":158,"type":20},"2026-05-01",{"date":160,"type":20},"2027-05-01",{"name":43,"class":44},{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":57,"phases":173,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":185,"locationsCount":45},"100598130","whole-body-vibration-and-balneotherapy-in-chronic-low-back-pain-100598130","NCT07067489","Whole-Body Vibration and Balneotherapy in Chronic Low Back Pain","The Effect of Whole-Body Vibration Exercises Combined With Balneotherapy on Pain, Function, and Sleep Quality in Patients With Chronic Low Back Pain","Whole-Body Vib","Inclusion Criteria:\n\n* Voluntary consent to participate in the study\n* Age between 18 and 65 years\n* Having chronic low back pain lasting at least 3 months or recurring at least 3 times per week\n* Diagnosis of chronic low back pain by a physical medicine and rehabilitation specialist\n* Normal neurological examination findings (no abnormal lower extremity reflexes or anesthesia)\n\nExclusion Criteria:\n\n* Presence of radicular pain or radiculopathy\n* Spondylolisthesis, spinal stenosis, vertebral infection, or cauda equina syndrome\n* Vertebral fracture, axial spondyloarthritis\n* History of lumbar spine surgery\n* Inflammatory rheumatic disease, psychiatric or neurological disorders\n* Uncontrolled hypertension, decompensated organ failure, or malignancy\n* Pregnancy or breastfeeding\n* Use of systemic steroids in the last 3 months\n* Major trauma or surgery within the past 6 months\n* Receiving physical therapy or physical modalities within the past 6 months\n* Any health condition that prevents participation in balneotherapy or exercise programs","65 Years",{"count":172,"type":20},60,[59],"This randomized controlled clinical trial aims to investigate the effects of whole-body vibration (WBV) exercises combined with balneotherapy on pain, physical function, sleep quality, and daily activity levels in individuals with chronic low back pain.\n\nA total of 60 volunteers aged 18 to 65 who have been diagnosed with chronic low back pain by a physical medicine and rehabilitation specialist and who meet the eligibility criteria will be included. Participants will be randomly assigned to two groups. Both groups will receive balneotherapy five days a week for three weeks. After balneotherapy, the first group will perform standard stretching, strengthening, and aerobic exercises designed for low back pain. The second group will receive the same exercise program in combination with WBV exercises using a vibration platform. WBV sessions will include static and dynamic exercises with specific frequency and amplitude settings.\n\nAll participants will be evaluated at baseline and after three weeks using validated measures, including pain intensity (Visual Analog Scale), spinal mobility (Modified Schober Test), balance and reach (Functional Reach Test), physical performance (Sit-to-Stand and Timed Up and Go Tests), disability (Oswestry Disability Index, Roland-Morris Questionnaire), and sleep quality (Pittsburgh Sleep Quality Index).\n\nThe study seeks to determine whether combining WBV with balneotherapy can provide additional benefits over standard exercise alone in managing chronic low back pain.",[176,177,178,123],"Balneology","Whole Body Vibration","Water","2026-04-29",{"date":181,"type":38},"2026-04-30",{"date":183,"type":38},"2025-07-01",{"date":130,"type":20},{"name":43,"class":44},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":16,"minAge":193,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":57,"phases":197,"briefSummary":199,"conditions":200,"keywords":204,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":220},"100619853","phase-4-calfactant-vs-poractant-alfa-using-a-less-invasive-technique-in-preterm-infants-with-respiratory-distress-syndrome-100619853","NCT07350018","Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome","Comparison of the Efficacy of Calfactant and Poractant Alfa Surfactants Administered by a Less Invasive Surfactant Administration Technique in Preterm Infants With Respiratory Distress Syndrome","Inclusion Criteria:\n\n* Born at a participating study center hospital.\n* Gestational age between 24 1\u002F7 and 29 6\u002F7 weeks (\\\u003C30 0\u002F7 weeks).\n* Postnatal age within the first 6 hours of life.\n* Being on non-invasive respiratory support.\n* Presence of clinical and radiological findings consistent with respiratory distress syndrome (RDS).\n* Indication for surfactant therapy defined as a requirement for FiO₂ \\>30% to achieve target oxygen saturation (SpO₂ 90-94%) while receiving noninvasive respiratory support with a minimum pressure of 6 cmH₂O.\n* Written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\n* Infants who were intubated for any reason before the decision to administer surfactant.\n* Severe birth asphyxia, defined as the need for advanced resuscitation after birth, 10th minute Apgar score ≤5, and arterial blood gas within the first hour of life showing pH \\\u003C7.0 and base excess (BE) ≤-12.\n* Presence of major congenital anomalies.\n* Respiratory distress due to causes other than respiratory distress syndrome (RDS).\n* Congenital heart disease.\n* Congenital diaphragmatic hernia.\n* Pulmonary hypoplasia.\n* Chromosomal abnormalities.\n* Presence of pneumothorax.\n* Lack of informed consent.\n* Neonatal seizures presence.\n* Postnatal age greater than 6 hours.\n* Infants born outside of gestational weeks 24 1\u002F7 - 29 6\u002F7.\n* Requirement for invasive mechanical ventilation at enrollment.\n* Infants receiving noninvasive respiratory support with an FiO₂ requirement \\\u003C0.30.","0 Hours","6 Hours",{"count":196,"type":20},234,[198],"PHASE4","Respiratory distress syndrome (RDS) is a common cause of respiratory failure in preterm infants and is frequently treated with surfactant therapy. With the increasing use of noninvasive ventilation, less invasive methods of surfactant administration have been developed. In the technique known as Less Invasive Surfactant Administration (LISA), surfactant is delivered into the trachea through a thin catheter, without the need for endotracheal intubation. This approach may reduce lung injury and improve respiratory outcomes in spontaneously breathing preterm infants. This multicenter, prospective, randomized study aims to compare the clinical effectiveness of poractant alfa and calfactant when administered using the LISA technique in preterm infants born at less than 30 weeks' gestation with RDS who are not intubated. The study will evaluate short-term outcomes, including the need for intubation, repeat surfactant administration, and respiratory support during the first 72 hours of life, as well as longer-term outcomes such as bronchopulmonary dysplasia and other neonatal morbidities.",[201,202,203],"Respiratory Distress Syndrome in Premature Infants","Respiratory Distress Syndrome (RDS)","Surfactant",[205,206,207,208,209,210,211],"Respiratory Distress Syndrome","Premature infant","Poractant alfa","Calfactant","surfactant treatment","Less Invasive Surfactant Administration","LISA","2026-04-27",{"date":214,"type":38},"2026-04-28",{"date":216,"type":38},"2026-01-20",{"date":218,"type":20},"2027-02-20",{"name":43,"class":44},5,{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":11,"sex":16,"minAge":193,"maxAge":194,"enrollmentInfo":228,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":229,"conditions":230,"keywords":232,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":240,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":246},"100623206","predictive-value-of-aeeg-and-cerebral-oxygenation-on-neurological-outcomes-in-newborns-with-mild-hypoxic-ischemic-encephalopathy-100623206","NCT07393620","Predictive Value of aEEG and Cerebral Oxygenation on Neurological Outcomes in Newborns With Mild Hypoxic-Ischemic Encephalopathy","Predictive Value of Amplitude-Integrated Electroencephalography and Cerebral Tissue Oxygenation on Neurological Outcomes in Neonates With Mild Hypoxic-Ischemic Encephalopathy","Inclusion Criteria:\n\n1. Gestational age and postnatal age:\n\n   Gestational age ≥ 36 0\u002F7 weeks and enrollment within the first 6 hours after birth.\n2. Blood gas criteria\n\n   Umbilical cord or postnatal (≤ 1 hour of life) blood gas showing:\n   1. pH ≤ 7.00 or base deficit ≥ 16 mmol\u002FL\n   2. OR, if pH is 7.01-7.15 or base deficit is 10-15.9 mmol\u002FL, the presence of both:\n\n      * An acute perinatal event, and\n      * Apgar score ≤ 5 at 10 minutes or ongoing resuscitation at 10 minutes of life, including the need for positive pressure ventilation.\n\n   ( Evidence of an acute peripartum and intrapartum asphyxia event, defined by at least one of the following: Uterine rupture, placental abruption, umbilical cord prolapse, rupture, tight nuchal cord, maternal hemorrhage, trauma, or cardiopulmonary arrest, vasa previa, category III fetal heart rate tracing, including having either a sinusoidal pattern or absent baseline variability plus recurrent late decelerations, recurrent variable decelerations, or bradycardia.)\n3. Clinical evidence of encephalopathy Findings consistent with Sarnat and Sarnat Stage 1 (mild) encephalopathy. Mild, moderate, or severe abnormalities may be present in at least one of the six categories (level of consciousness, spontaneous activity, posture, tone, primitive reflexes \\[suck and Moro\\], autonomic nervous system), provided that no more than two categories show moderate or severe findings.\n\nExclusion Criteria:\n\nNewborns meeting any of the following criteria will be excluded from the study:\n\n1. Normal neurological examination Newborns with a completely normal neurological examination according to Sarnat and Sarnat staging.\n2. Moderate or severe encephalopathy within the first 6 hours of life\n\n   1. Clinical findings consistent with moderate or severe encephalopathy during the first 6 hours after birth.\n   2. Presence of clinical seizures.\n   3. aEEG findings consistent with moderate or severe encephalopathy requiring therapeutic hypothermia.\n   4. Evidence of electrographic seizure activity on aEEG monitoring.\n3. Sarnat and Sarnat criteria for moderate-severe encephalopathy Findings consistent with moderate or severe encephalopathy in three or more Sarnat categories, classified as moderate or severe hypoxic-ischemic encephalopathy.\n4. Contraindications to therapeutic hypothermia, including:\n\n   * Evaluation occurring more than 6 hours after birth.\n   * Gestational age \\\u003C 36 weeks or birth weight \\\u003C 2000 g.\n   * Severe or extensive intracranial parenchymal hemorrhage.\n   * Severe, life-threatening coagulopathy.\n   * Intracerebral infarction.\n   * Chromosomal abnormalities (e.g., trisomy 13 or 18) or major congenital anomalies involving multiple organ systems.\n5. Lack of parental informed consent\n6. Cyanotic congenital heart disease\n7. Metabolic encephalopathy Encephalopathy due to metabolic disorders not related to hypoxic-ischemic events.\n8. Other conditions associated with encephalopathy unrelated to acute hypoxia\n\n   * Abnormal fetal growth.\n   * Maternal infections.\n   * Fetomaternal hemorrhage.\n   * Severe neonatal sepsis.\n   * Chronic placental lesions.",{"count":117,"type":20},"Newborns with mild hypoxic-ischemic encephalopathy usually do not receive cooling treatment. However, some of these newborns may develop neurological problems later in life. This observational study aims to evaluate whether early brain monitoring and measurements of brain oxygen levels are associated with neurological outcomes in newborns with mild hypoxic-ischemic encephalopathy. Newborns will be monitored during the first 72 hours after birth as part of routine clinical care. Neurological assessments will be performed during early infancy and later follow-up. The findings of this study may help improve early risk assessment and support closer monitoring of newborns who may be at increased risk for unfavorable neurological outcomes.",[231],"Hypoxic-Ischemic Encephalopathy Mild",[233,234,235,236,237,238,239],"Mild Hypoxic Ischemic Encephalopathy","Amplitude-integrated electroencephalography","Cerebral oxygenation","Near infrared spectroscopy","Neonates","aEEG","NIRS",{"date":158,"type":38},{"date":242,"type":38},"2026-02-10",{"date":244,"type":20},"2029-02-10",{"name":43,"class":44},3,{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":254,"enrollmentInfo":255,"targetDuration":254,"studyType":21,"phases":4,"briefSummary":257,"conditions":258,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":261,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":45},"100617924","the-role-of-electroencephalography-in-caffeine-discontinuation-timing-in-premature-infants-100617924","NCT07324941","The Role of Electroencephalography in Caffeine Discontinuation Timing in Premature Infants","The Role of Electroencephalography Evaluation in Caffeine Discontinuation Timing in Premature Infants","Inclusion Criteria:\n\n1. Infants born before 28 weeks of gestation with a birth weight of 1250 grams or less, who received prophylactic caffeine therapy.\n2. Infants with a birth weight greater than 1250 grams and a gestational age below 32 weeks, who required invasive mechanical ventilation and were started on prophylactic caffeine therapy.\n3. Infants born at less than 37 weeks of gestation, admitted to the neonatal intensive care unit, and treated with caffeine for apnea of prematurity.\n4. Infants whose parents or legal guardians provided informed consent.\n\nExclusion Criteria:\n\n1. Infants who did not receive caffeine therapy,\n2. Infants for whom an EEG could not be performed,\n3. Infants with major congenital malformations such as neuromuscular disorders, central nervous system developmental abnormalities, thoracic malformations, or major cardiac anomalies,\n4. Infants who were transferred to another facility within one week before or after discontinuation of caffeine therapy.","1 Month",{"count":256,"type":20},100,"The aim of this observational study is to investigate whether functional maturation assessment by electroencephalography in preterm infants can provide reliable data for the safe discontinuation of caffeine therapy without recurrence of apnea.\n\nIn preterm infants receiving caffeine therapy, an assessment of maturation will be performed by EEG at the time when discontinuation of caffeine treatment is planned.",[259,260],"Apnea Neonatal","Apnea of Prematurity",{"date":158,"type":38},{"date":263,"type":38},"2026-01-02",{"date":265,"type":20},"2027-01-02",{"name":43,"class":44},{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":53,"sex":16,"minAge":274,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":57,"phases":277,"briefSummary":278,"conditions":279,"keywords":284,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":4},"100635236","effect-of-game-based-breathing-exercise-on-pain-fear-and-anxiety-in-children-during-venipuncture-100635236","NCT07550062","Effect Of Game-Based Breathing Exercise On Pain, Fear, And Anxiety In Children During Venipuncture","The Effect Of Video Game-Based Breathing Exercise Intervention On Pain, Fear, And Anxiety During Routine Venipuncture In Pediatric Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Being between 7-12 years of age\n\n  * Undergoing a venipuncture procedure\n  * Able to understand and speak Turkish\n  * Having written informed consent from the parent\u002Flegal guardian and age-appropriate verbal assent from the child\n\nExclusion Criteria:\n\n* • History of epilepsy or recurrent seizures\n\n  * Presence of severe congenital chronic disease, congenital anomaly, or behavioral disorder\n  * Presence of visual or hearing impairment, or cognitive\u002Fdevelopmental delay\n  * Use of psychoactive medications\n  * Presence of oral, lip, or orofacial anomalies that may interfere with breathing exercises","7 Years","12 Years",{"count":172,"type":20},[59],"Venipuncture is one of the most common invasive procedures in children and is often associated with significant pain, fear, and anxiety.This randomized controlled study will aim to evaluate the effects of a video game-based breathing exercise intervention on pain, fear, and anxiety levels in children aged 7-12 years undergoing routine venipuncture. While the intervention group will receive a video game-based breathing exercise using the BREATHING+ system in addition to standard care, the control group will receive routine venipuncture procedures only. The study population will consist of children aged 7-12 years who meet the inclusion criteria and whose parents\u002Flegal guardians provide informed consent. Participants will be randomly assigned to intervention and control groups. Pain, fear, and anxiety levels will be assessed at three time points: before the procedure, during the procedure, and immediately after the procedure. Data will be collected using the Visual Analog Scale (VAS), Children's Anxiety Scale-State (CAS-S), and Children's Fear Scale (CFS), along with a structured questionnaire form. All assessments will be conducted at the predefined time points.",[280,281,282,283],"Non-Pharmacological Interventions","Breathing Exercise","Venipuncture Pain","Pain Management",[285,286,287,288],"Pediatric venipuncture","Pain management","Breathing exercise","Non-pharmacological intervention","2026-04-17",{"date":291,"type":38},"2026-04-24",{"date":293,"type":20},"2026-05",{"date":295,"type":20},"2027-05",{"name":43,"class":44},{"id":298,"slug":299,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":4,"eligibilityCriteria":303,"healthyVolunteers":11,"sex":304,"minAge":17,"maxAge":305,"enrollmentInfo":306,"targetDuration":4,"studyType":57,"phases":308,"briefSummary":309,"conditions":310,"keywords":315,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":45},"100632175","investigation-of-the-effects-of-serratus-posterior-superior-intercostal-plane-block-and-serratus-anterior-plane-block-on-perioperative-analgesia-management-in-patients-scheduled-for-mastectomy-100632175","NCT07510269","Investigation of the Effects of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block on Perioperative Analgesia Management in Patients Scheduled for Mastectomy","Mastektomi Planlanan Hastalarda Serratus Posterior Superior İnterkostal Plan Bloğu Ile Serratus Anterior Plan Bloğunun Peroperatif Analjezi Yönetimi Üzerine Etkilerinin Araştırılması","Inclusion Criteria:\n\n* Female patients aged between 18 and 75 years\n* Patients scheduled for elective mastectomy surgery\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients who refuse to participate in the study\n* Patients with American Society of Anesthesiologists (ASA) physical status IV or V\n* Patients receiving anticoagulant therapy or with suspected coagulopathy\n* Patients with known allergy to local anesthetic agents\n* Infection at the site of block application\n* Pregnant patients or those with suspected pregnancy\n* Patients with severe neurological or psychiatric disorders\n* Patients with severe cardiovascular disease\n* Patients with chronic opioid use\n* Patients with hepatic failure or renal failure (glomerular filtration rate \\\u003C15 mL\u002Fmin\u002F1.73 m²)","FEMALE","75 Years",{"count":307,"type":20},66,[59],"This study aims to evaluate and compare the analgesic efficacy of two ultrasound-guided regional anesthesia techniques, the serratus anterior plane (SAP) block and the serratus posterior superior intercostal plane (SPSIP) block, in patients undergoing elective mastectomy surgery. Postoperative pain following mastectomy is a common and significant clinical problem that negatively affects patient comfort, delays mobilization, and may prolong hospital stay. Although systemic analgesics are commonly used, they are associated with adverse effects such as sedation, constipation, and potential dependency.\n\nIn this randomized clinical study, female patients aged 18-75 years with ASA physical status I-III scheduled for elective mastectomy will be included after obtaining informed consent. Patients will be allocated into two groups to receive either SAP block or SPSIP block under ultrasound guidance prior to surgery. Standardized general anesthesia and perioperative analgesia protocols will be applied to all patients.\n\nThe primary objective is to compare postoperative pain scores between the two groups using the Numeric Rating Scale (NRS). Secondary outcomes include time to first analgesic requirement, total analgesic consumption, intraoperative opioid use, and hemodynamic parameters. By comparing these two interfascial plane blocks, this study aims to identify a more effective analgesic technique that improves postoperative pain control, enhances patient comfort, and facilitates early mobilization following mastectomy.",[311,312,313,314],"Postoperative Pain","Nerve Block","Mastectomy","Patient Outcome Assessment",[316,317,318,319],"Serratus Posterior Superior Intercostal Plane Block","Serratus Anterior Plane Block","Multimodal Analgesia","Mastectomy Surgery","2026-03-29",{"date":322,"type":38},"2026-04-03",{"date":324,"type":38},"2025-10-15",{"date":326,"type":20},"2026-10-15",{"name":43,"class":44},{"id":329,"slug":330,"hasResults":11,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":4,"eligibilityCriteria":334,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":335,"enrollmentInfo":336,"targetDuration":4,"studyType":57,"phases":338,"briefSummary":339,"conditions":340,"keywords":344,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":45},"100629255","comparison-of-erector-spinae-plane-block-espb-with-the-combination-of-superficial-parasternal-intercostal-plane-block-spipb-and-serratus-anterior-plane-block-sapb-in-the-management-of-postoperative-sternotomy-pain-in-patients-undergoing-cardiac-surgery-via-sternotomy-100629255","NCT07472296","Comparison of Erector Spinae Plane Block (ESPB) With the Combination of Superficial Parasternal Intercostal Plane Block (SPIPB) and Serratus Anterior Plane Block (SAPB) in the Management of Postoperative Sternotomy Pain in Patients Undergoing Cardiac Surgery Via Sternotomy","Sternotomi İle Kardiyak Cerrahi Planlanan Hastalarda Postoperatif Sternotomi Ağrısının Yönetiminde Erektör Spina Plan Blok (ESPB) Ile Yüzeyel Parasternal İnterkostal Plan Bloğu (SPIPB) ve Serratus Anterior Plan Bloğu (SAPB) Kombinasyonunun Karşılaştırılması","Inclusion Criteria:\n\n* Patients aged between 18 and 80 years.\n* Patients classified as American Society of Anesthesiologists (ASA) physical status I, II, or III.\n* Patients scheduled for elective cardiac surgery via median sternotomy.\n* Patients who have provided written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or suspected pregnancy.\n* Body Mass Index (BMI) \\> 35 kg\u002Fm².\n* Known allergy or hypersensitivity to local anesthetics (e.g., bupivacaine).\n* Suspected coagulopathy or bleeding disorders.\n* Infection at the site of the regional block injection.\n* Severe hepatic or renal failure.\n* Severe neurological or psychiatric disorders.\n* Emergency surgical procedures.\n* Re-operation cases (Redo-surgery)","80 Years",{"count":337,"type":20},50,[59],"This study aims to compare the effectiveness of two regional anesthesia techniques in managing pain for participants undergoing cardiac surgery via sternotomy. The investigators will evaluate whether the Erector Spinae Plane Block (ESPB) or a combination of the Superficial Parasternal Intercostal Plane Block (SPIPB) and Serratus Anterior Plane Block (SAPB) provides better pain control and recovery outcomes.",[311,341,342,343,283],"Sternotomy Pain","Acute Pain","Cardiac Surgery",[345,317,346,347,318],"Erector Spinae Plane Block","Superficial Parasternal Intercostal Plane Block","Opioid Consumption","2026-03-13",{"date":350,"type":38},"2026-03-16",{"date":352,"type":38},"2025-11-01",{"date":354,"type":20},"2026-11",{"name":43,"class":44},{"id":357,"slug":358,"hasResults":11,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":362,"eligibilityCriteria":363,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":364,"enrollmentInfo":365,"targetDuration":4,"studyType":57,"phases":367,"briefSummary":368,"conditions":369,"keywords":371,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":379,"completionDateStruct":380,"leadSponsor":382,"locationsCount":45},"100629740","effect-of-erector-spinae-plane-block-on-postoperative-respiratory-function-after-laparoscopic-cholecystectomy-100629740","NCT07478601","Effect of Erector Spinae Plane Block on Postoperative Respiratory Function After Laparoscopic Cholecystectomy","Effect of Ultrasound-Guided Erector Spinae Plane Block on Postoperative Pain and Respiratory Function in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Study","ESP-LC","Inclusion Criteria:\n\nAge between 18 and 65 years ASA physical status I-III-- III Patients scheduled for elective laparoscopic cholecystectomy under general anesthesia Ability to perform spirometry tests Provision of written informed consent\n\nExclusion Criteria:\n\nPatient refusal to participate Chronic pulmonary disease (e.g., COPD, asthma, restrictive lung disease) Morbid obesity (BMI ≥ 35 kg\u002Fm²) Coagulopathy or anticoagulant therapy Local infection at the block site Allergy to local anesthetic agents Pregnancy Previous thoracic surgery Neuromuscular disease affecting respiratory function Conversion from laparoscopic to open surgery Inability to perform postoperative spirometry","70 Years",{"count":366,"type":20},70,[59],"Postoperative pulmonary dysfunction is frequently observed after laparoscopic abdominal surgery due to the combined effects of general anesthesia, pneumoperitoneum, diaphragmatic dysfunction, and postoperative pain. These factors may impair respiratory mechanics, reduce lung volumes, and negatively affect postoperative recovery. Effective postoperative analgesia plays a crucial role in preserving respiratory function by allowing adequate ventilation and reducing pain-related respiratory limitation.\n\nThe erector spinae plane (ESP) block is a relatively novel ultrasound-guided fascial plane block that provides thoracoabdominal analgesia through the spread of local anesthetic along the paraspinal fascial planes. By reducing postoperative pain and opioid consumption, ESP block may contribute to improved respiratory mechanics and preservation of postoperative pulmonary function.\n\nThe aim of this prospective randomized controlled study is to evaluate the effect of ultrasound-guided erector spinae plane block on postoperative respiratory function and pain in patients undergoing elective laparoscopic cholecystectomy. Patients will be randomized into two groups: an ESP block group receiving bilateral ultrasound-guided erector spinae plane block and a control group receiving standard analgesic management.\n\nPostoperative respiratory parameters will be evaluated using spirometry measurements including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), the FEV1\u002FFVC ratio, and forced expiratory flow at 25-75% of the pulmonary volume (FEF25-75). In addition, arterial blood gas parameters and postoperative pain scores will be assessed and compared between the groups.\n\nThe study aims to determine whether ultrasound-guided erector spinae plane block improves postoperative respiratory function and contributes to better postoperative recovery in patients undergoing laparoscopic cholecystectomy.",[370],"Cholelithiasis",[370,345,372,373,311,374,375],"Postoperative Respiratory Function","Laparoscopic Cholecystectomy","Regional Anesthesia","Spirometry","2026-03-12",{"date":378,"type":38},"2026-03-17",{"date":100,"type":20},{"date":381,"type":20},"2027-06-25",{"name":43,"class":44},{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":335,"enrollmentInfo":390,"targetDuration":4,"studyType":57,"phases":391,"briefSummary":392,"conditions":393,"keywords":395,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":45},"100627745","comparison-of-the-efficacy-of-combined-transversus-thoracic-plane-block-and-serratus-anterior-plane-block-versus-erector-spinae-plane-block-in-the-management-of-sternotomy-pain-100627745","NCT07452627","Comparison of the Efficacy of Combined Transversus Thoracic Plane Block and Serratus Anterior Plane Block Versus Erector Spinae Plane Block in the Management of Sternotomy Pain","STERNOTOMİ AĞRISININ YÖNETİMİNDE TRANSVERSUS TORASİK PLAN BLOK VE SERRATUS ANTERİOR PLAN BLOK KOMBİNASYONU İLE EREKTÖR SPİNA PLAN BLOK ETKİNLİĞİNİN KARŞILAŞTIRILMASI","Inclusion Criteria:\n\n* Patients aged between 18 and 80 years.\n* Patients with American Society of Anesthesiologists (ASA) physical status I, II, or III.\n* Patients who provide written informed consent.\n* Patients scheduled for cardiac surgery via elective sternotomy.\n\nExclusion Criteria:\n\n* Pregnancy or suspected pregnancy\n* Body Mass Index (BMI) \\> 35 kg\u002Fm²\n* History of allergy to local anesthetics or opioids\n* Suspected coagulopathy or infection at the injection site\n* Severe neurological, psychiatric, hepatic, or renal failure",{"count":337,"type":20},[59],"Background and Purpose: Median sternotomy is the standard surgical approach for cardiac procedures, yet it is associated with significant postoperative pain. Inadequate pain management can lead to pulmonary complications and chronic pain syndromes. While opioids are a cornerstone of multimodal analgesia, their side effects-such as sedation, respiratory depression, and nausea-can delay recovery. Furthermore, neuraxial techniques like epidural analgesia are often avoided in cardiac surgery due to the risks associated with systemic heparinization. This study aims to compare the efficacy of two non-neuraxial regional anesthesia techniques: the combination of Transversus Thoracic Plane Block (TTPB) and Serratus Anterior Plane Block (SAPB) versus the Erector Spinae Plane Block (ESPB).\n\nStudy Design and Population: This prospective, randomized study includes 50 patients (ASA I-III, aged 18-80) undergoing elective cardiac surgery via median sternotomy. Patients are randomized into two groups:\n\nTTPB + SAPB Group: Patients receive ultrasound-guided blocks targeting the anterior and lateral chest wall.\n\nESPB Group: Patients receive ultrasound-guided blocks targeting the paravertebral and intercostal spaces from a posterior approach.\n\nIntervention and Procedures: Following standardized anesthesia induction and invasive monitoring, the respective blocks are performed under ultrasound guidance. Intraoperative hemodynamic data are recorded at key surgical stages (incision, sternotomy, CPB). In the postoperative period in the intensive care unit (ICU), all patients will receive a standardized multimodal analgesia protocol including intravenous (IV) paracetamol and IV tenoxicam. While patients are intubated, pain will be assessed using the Behavioral Pain Scale (BPS). If the BPS score is above 3, IV fentanyl will be administered as rescue analgesia.\n\nFollowing extubation, pain levels will be evaluated using the Visual Analog Scale (VAS) at rest and during coughing at specific time points (0, 1, 2, 4, 8, 12, 16, and 24 hours). If the post-extubation VAS score is 4 or higher, intramuscular meperidine will be given as rescue analgesia. Additionally, IV ondansetron will be administered in case of nausea or vomiting. The study will also evaluate the time to extubation, time to clinical transport, and patient\u002Fsurgeon satisfaction using a 5-point Likert scale.\n\nPrimary and Secondary Outcomes:\n\nThe primary objective of this study is to compare postoperative pain intensity between the study groups using the Visual Analog Scale (VAS) (0-10) and the Behavioral Pain Scale (BPS) (3-12).\n\nSecondary objectives include:\n\nOpioid Consumption: Comparison of total intraoperative and postoperative opioid (IV fentanyl and IM meperidine) consumption within the first 24 hours.\n\nRecovery Milestones: Measurement of time to extubation, time to first mobilization, and time to clinical transport to the surgical ward.\n\nClinical Satisfaction and Safety: Assessment of patient and surgeon satisfaction using a 5-point Likert scale, and monitoring the incidence of opioid-related side effects, specifically postoperative nausea and vomiting (PONV) requiring ondansetron.\n\nExpected Impact:\n\nBy identifying the most effective regional anesthesia technique (TTPB+SAPB vs. ESPB) in conjunction with a standardized multimodal analgesia protocol (IV paracetamol and tenoxicam), this study seeks to maximize postoperative pain control and patient comfort. The results aim to achieve superior analgesia with lower pain scores, thereby facilitating earlier mobilization, reducing the incidence of postoperative complications, and enhancing the overall recovery process for patients undergoing cardiac surgery via median sternotomy. This approach ultimately contributes to the development of more effective, pain-centered recovery protocols in the intensive care unit.",[311,394,312,314],"Sternotomy",[396,317,345,341,343,318],"Transversus Thoracic Plane Block","2026-03-06",{"date":399,"type":38},"2026-03-10",{"date":401,"type":38},"2025-12-01",{"date":403,"type":20},"2026-12",{"name":43,"class":44},{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":305,"enrollmentInfo":411,"targetDuration":4,"studyType":57,"phases":412,"briefSummary":413,"conditions":414,"keywords":416,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":420,"startDateStruct":422,"completionDateStruct":424,"leadSponsor":426,"locationsCount":4},"100614964","the-effect-of-whole-body-vibration-therapy-following-botulinum-toxin-a-injection-on-spasticity-and-balance-in-stroke-patients-100614964","NCT07286435","The Effect of Whole-Body Vibration Therapy Following Botulinum Toxin A Injection on Spasticity and Balance in Stroke Patients","Inclusion criteria:\n\n* Participants with unilateral hemiparesis due to hemorrhage or infarction\n* Participants aged 18-75 years\n* Participants with MAS ≥2 spasticity in the ankle\n* Participants with a Mini-Mental State Examination (MMSE) score of 24, indicating preserved cognitive and communication abilities\n* Participants who can walk at least 100 meters with or without assistive devices\n* Participants without joint contractures and with sufficient motor control to perform functional walking tests\n* Participants who have not previously undergone vibration therapy\n\nExclusion Criteria:\n\n* History of neurological disease (such as polyneuropathy or motor neuron diseases) other than a history of existing stroke\n* History of recent fracture in the lower extremity\n* Severe degenerative joint disease\n* History of implants in the lower extremity or spine\n* History of cardiac pacemakers\n* Presence of uncontrolled hypertension and uncontrolled diabetes\n* History of recent thromboembolism or infection\n* Participants whose antispasmodic medication regimen was changed within 1 month prior to starting treatment",{"count":337,"type":20},[59],"The purpose of this clinical study is to evaluate the effect of Whole Body Vibration (WBV) therapy, applied two weeks after botulinum toxin type A (BoNT-A) injection, on spasticity and balance parameters in individuals with stroke who have ankle spasticity. The main questions it aims to answer are: Adjuvant WBV therapy administered after BoNT-A injection;\n\n* Does it effectively improve spasticity?\n* Is it an effective intervention for balance and walking functions? Researchers will compare the application of WBV to a placebo application (a vibration-free application) to evaluate the effect of adjuvant WBV therapy administered after BoNT-A injection on ankle spasticity, balance, and walking function in individuals with stroke.",[415],"Stroke Gait Rehabilitation",[417,418],"stroke, whole body vibration, spasticity, balance","gait","2025-12-02",{"date":421,"type":38},"2025-12-16",{"date":423,"type":20},"2025-12",{"date":425,"type":20},"2026-09",{"name":43,"class":44},{"id":428,"slug":429,"hasResults":11,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":4,"eligibilityCriteria":433,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":434,"targetDuration":4,"studyType":57,"phases":436,"briefSummary":437,"conditions":438,"keywords":444,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":451,"lastUpdatePostDateStruct":452,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":458,"locationsCount":45},"100598953","the-effect-of-peg-use-education-on-the-care-burden-and-quality-of-life-of-patients-relatives-100598953","NCT07078188","The Effect of PEG Use Education on the Care Burden and Quality of Life of Patients' Relatives","The Effect of Discharge Education on PEG Use Given to Palliative Care Patients' Relatives on the Care Burden and Quality of Life of Patients' Relatives","Inclusion Criteria:\n\n* The caregiver must be over 18 years old\n* The caregiver must be willing and able to participate in the study\n* The caregiver must be primarily responsible for the patient's care\n* The patient they are caring for must be receiving palliative care\n* The patient they are caring for must be receiving PEG feeding\n* The patient they are caring for must be over 18 years old\n* The patient they are caring for must have been diagnosed with stroke at least six months ago\n* The caregiver must have a mini mental test score of 25 points or more\n* The Beck depression scale score must be under 17 points\n* The caregiver must have a score of over 16 points on the Readiness to Provide Care Scale\n\nExclusion Criteria:\n\n* The caregiver is under the age of 18\n* The caregiver is not willing and able to participate in the research\n* The caregiver has a physical disability or serious health problem that makes it difficult to provide care\n* The patient they are caring for is under the age of 18\n* The patient they are caring for has been diagnosed with cancer, endocrine system or GI disease\n* The caregiver has a mini mental test score of less than 25\n* The Beck depression scale score is 17 points or higher\n* The caregiver has scored 16 or lower on the Readiness to Provide Care Scale\n* The caregiver has communication problems\n* The caregiver has been diagnosed with depression or psychiatric disorder\n* The caregiver is receiving psychotherapy\u002Fpsychological support\n* The caregiver is taking antidepressants and\u002For anxiolytics\n* The caregiver has sensory loss related to vision and hearing",{"count":435,"type":20},62,[59],"The study was planned to evaluate the effects of discharge training on PEG use given to palliative care patients' relatives on the caregiver burden and quality of life of the relatives.\n\nThe main questions that the study aims to answer are as follows:\n\n* How does PEG training given before discharge affect the knowledge level of caregivers on PEG use?\n* How does PEG training given before discharge affect the caregiver burden?\n* How does PEG training given before discharge affect the caregiver's caregiver stress?\n* How does PEG training given before discharge affect the quality of life of the caregivers?\n\nThe researchers will compare the PEG training given before discharge with a control group that did not receive training in this regard in order to evaluate the effects of PEG training given before discharge on the caregiver burden, caregiver stress and quality of life of the caregivers. The study will use a general information form, the Caregiver Burden Scale, the Caregiver Stress Index Form, the SF 36 Quality of Life Scale, and the Percutaneous Endoscopic Gastrostomy Tube Nutrition Information Scale for Caregivers.\n\nParticipants:\n\n* Face-to-face interviews will be conducted with caregivers at 0, 1, and 3 months.\n* The forms used in the study will be filled out at each interview.\n* The intervention group will be trained only at the first interview.",[439,440,441,442,443],"Palliative Care","Caregiver","Caregiver Burden of Caregivers","Quality of Life of Caregivers","PEG Training",[445,446,447,440,448,449,450],"Palliative care","Nutrition","PEG","caregiver burden","Quality of life","PEG training","2025-07-12",{"date":453,"type":38},"2025-07-22",{"date":455,"type":38},"2023-07-06",{"date":457,"type":20},"2025-10-30",{"name":43,"class":44},{"id":460,"slug":461,"hasResults":11,"nctId":462,"briefTitle":463,"officialTitle":463,"acronym":4,"eligibilityCriteria":464,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":465,"enrollmentInfo":466,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":468,"conditions":469,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":476,"leadSponsor":478,"locationsCount":4},"100593962","burnout-syndrome-among-anesthesiology-residents-in-turkey-a-cross-sectional-study-100593962","NCT07013253","Burnout Syndrome Among Anesthesiology Residents in Turkey: A Cross-sectional Study","Inclusion Criteria:\n\n* Agreed to participate by completing the online survey form\n* Proficient in the Turkish language\n* Anesthesiology and Reanimation residents currently practicing in the Republic of Turkey\n\nExclusion Criteria:\n\n• Participants who do not provide consent to share the requested information in the survey form","99 Years",{"count":467,"type":20},500,"Burnout syndrome is a condition in which an individual experiences loss of self-esteem, chronic fatigue, feelings of helplessness, and hopelessness in their professional work life and human relationships. This study aims to evaluate the prevalence of burnout syndrome among anesthesiology residents working in Turkey, analyze the potential causes and adverse consequences of this syndrome's increase, and provide recommendations for its reduction.",[470,471],"Burnout, Professional","Burnout, Psychological","2025-06-15",{"date":474,"type":38},"2025-06-17",{"date":472,"type":20},{"date":477,"type":20},"2026-12-31",{"name":43,"class":44},{"id":480,"slug":481,"hasResults":11,"nctId":482,"briefTitle":483,"officialTitle":483,"acronym":4,"eligibilityCriteria":484,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":465,"enrollmentInfo":485,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":486,"conditions":487,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":492,"leadSponsor":493,"locationsCount":4},"100593963","burnout-syndrome-among-anesthesiologists-in-turkey-a-cross-sectional-study-100593963","NCT07013266","Burnout Syndrome Among Anesthesiologists in Turkey: A Cross-sectional Study","Inclusion Criteria:\n\nI. Agreed to participate by completing the online survey form. II. Proficient in the Turkish language. III. Anesthesiology and Reanimation specialists currently practicing in the Republic of Turkey.\n\nExclusion Criteria:\n\nI. Users who do not provide consent to share the requested information in the survey form.",{"count":467,"type":20},"Burnout syndrome is a condition in which an individual experiences loss of self-esteem, chronic fatigue, feelings of helplessness, and hopelessness in their professional work life and human relationships. This study aims to evaluate the prevalence of burnout syndrome among anesthesiologists working in Turkey, analyze the potential causes and adverse consequences of this syndrome's increase, and provide recommendations for its reduction.",[470,471],"2025-06-02",{"date":490,"type":38},"2025-06-10",{"date":488,"type":20},{"date":477,"type":20},{"name":43,"class":44},{"id":495,"slug":496,"hasResults":11,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":4,"eligibilityCriteria":500,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":335,"enrollmentInfo":501,"targetDuration":4,"studyType":57,"phases":503,"briefSummary":504,"conditions":505,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":511,"leadSponsor":512,"locationsCount":4},"100575927","postoperative-analgesic-comparison-of-spsi-block-and-sap-block-in-video-assisted-thoracoscopic-surgery-vats-100575927","NCT06778642","Postoperative Analgesic Comparison of SPSI Block and SAP Block in Video-Assisted Thoracoscopic Surgery (VATS)","Comparison of the Postoperative Analgesic Effectiveness of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block in Video-Assisted Thoracoscopic Surgery (VATS)","Inclusion Criteria:\n\n* Patients aged 18 to 80 years undergoing Video-Assisted Thoracoscopic Surgery (VATS)\n* Scheduled at Uludağ University Faculty of Medicine Hospital Operating Room\n* Classified as ASA I, II, or III according to the American Society of Anesthesiologists (ASA) criteria\n\nExclusion Criteria:\n\n* Allergy to local anesthetics or contraindications to bupivacaine\n* Known or suspected coagulopathy\n* Infection at the injection site\n* History of thoracic surgery\n* Severe neurological or psychiatric disorders\n* Severe cardiovascular disease\n* Liver failure\n* Renal failure (glomerular filtration rate \\\u003C 15 ml\u002Fmin\u002F1.73 m²)\n* Chronic opioid use",{"count":502,"type":20},90,[59],"In our study, we primarily aimed to compare the postoperative analgesic effectiveness of the Serratus Posterior Superior Intercostal Plane Block and the Serratus Anterior Plane Block, both routinely applied in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS)",[506],"Acute Post Operative Pain","2025-05-12",{"date":509,"type":38},"2025-05-15",{"date":509,"type":20},{"date":242,"type":20},{"name":43,"class":44},{"id":514,"slug":515,"hasResults":11,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":4,"eligibilityCriteria":519,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":57,"phases":522,"briefSummary":523,"conditions":524,"keywords":528,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":540,"locationsCount":45},"100566047","artificial-intelligence-supported-mobile-application-for-diabetes-self-management-100566047","NCT06650098","Artificial Intelligence-Supported Mobile Application For Diabetes Self-Management","The Effect of Web-Based and Artificial Intelligence-Assisted Personalized Applications on Knowledge Levels Compliance With Treatment and Self-Management Among Diabetic Individuals","Inclusion Criteria:\n\n* Having been diagnosed with diabetes for at least 1 year\n* Being between the ages of 18-65\n* Being open to verbal communication\n* Being able to read and write and speak Turkish\n* Having a smart android phone and being able to use mobile applications\n* Being willing to participate in the study\n\nExclusion Criteria:\n\n* Having a perception disorder and psychiatric disorder that prevents the patient from communicating,\n* Having a condition that prevents them from using a smart phone (advanced retinopathy and neuropathy, internet problems)\n* Being on intensive insulin treatment\n* Having a condition that prevents them from continuing the application phase of the study\n* Wanting to leave the study",{"count":521,"type":20},156,[59],"Patients in the AI-supported mobile application group will be able to log in with a username and password that will be defined specifically for them. Patients will be informed about how the application is used during their first interview. They will enter their personal and disease characteristics (age, gender, height, weight, HbA1C, HDL, LDL) into the application at the entrance. Other sections of the application will include exercise, nutrition, medication tracking, complication tracking and diabetic foot care sections. The person will be asked to enter relevant information in these fields according to their own life and condition (for example; how many times do you use insulin per day, what are your medication times, how do you spend your day in terms of exercise, how many meals do you eat, what is your diet, do you urinate frequently, are you extremely thirsty, are you hungry often, do you have numbness in your hands and feet, etc.). After the patient enters the necessary information, they will also be asked to enter their daily blood sugar measurement values into the system. Thus, the individual\\'s hypo\u002Fhyperglycemia risk, risk analysis, nutrition recommendations, medication reminder system, exercise reminder and incentive warnings will be communicated to the individual thanks to the AI-based mobile application. The aim of this application is to reduce the risk of complications and improve the individual\\'s quality of life by providing personalized recommendations for all the needs of the individual, including alarms and reminders, and to support patients to continue their diabetes education and disease management more actively.",[525,526,527],"Diabetes Mellitus","Artificial Intelligence (AI)","Self-management",[529,530,531,532,533],"diabetes mellitus","artificial intelligence","self-management","level of knowledge","compliance with Treatment","2025-03-24",{"date":536,"type":38},"2025-03-25",{"date":538,"type":20},"2025-04-01",{"date":102,"type":20},{"name":43,"class":44},{"id":542,"slug":543,"hasResults":11,"nctId":544,"briefTitle":545,"officialTitle":546,"acronym":4,"eligibilityCriteria":547,"healthyVolunteers":11,"sex":16,"minAge":548,"maxAge":335,"enrollmentInfo":549,"targetDuration":4,"studyType":57,"phases":550,"briefSummary":551,"conditions":552,"keywords":554,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":565,"locationsCount":4},"100582562","the-effect-of-hot-foot-bath-on-sleep-quality-and-fatigue-100582562","NCT06864923","The Effect of Hot Foot Bath on Sleep Quality and Fatigue","Investigation of the Effect of Hot Foot Bath on Sleep Quality and Fatigue","Inclusion Criteria:\n\n* being over the age of 18,\n* having no disorder which could affect pain perception,\n* having no communication problem, and voluntarily agreeing to participate in the research,\n* Having been admitted to the clinic at least 24 hours ago,\n* Not having a diagnosed sleep disorder,\n* Not having a psychiatric disorder requiring treatment,\n* Not having a problem with vital signs before the application,\n* Not using narcotic drugs in the last 4 hours,\n* Not eating two hours before going to bed at night\n\nExclusion Criteria:\n\n* being under the age of 18\n* not being conscious, refusing to participate in the research or opting to leave the study at any point,\n* Having a problem with vital signs before the application,\n* Having a diagnosed sleep disorder.","20 Years",{"count":172,"type":20},[59],"This study will be conducted to investigate the effects of hot foot baths on patients' sleep quality and fatigue severity levels.The study will be conducted in the Gastroenterology clinic of a university hospital in Türkiye. The research sample will consist of 60 adult patients. Patients will be randomly divided into two groups: the intervention and control groups. The intervention group will receive hot foot baths for three consecutive nights starting from the second day of hospitalization. The foot bath will be applied one hour before the patient goes to bed at night. The foot tub will be filled with hot water to approximately 20 cm above the patient's ankle and the temperature of the water will be measured with a water thermometer. The temperature of the water will be kept stable at 41-42°C. This application will be done for 20 minutes. The sleep and fatigue levels of the patients will be measured with measurement tools in the morning (3 times) following each application. No application will be applied to the control group, and sleep and fatigue levels will be measured in a similar manner to the measurement tools applied to the intervention group and the application days.",[553],"Hepatitis B",[555,556,557],"fatigue","sleep quality","foot bath","2025-03-07",{"date":560,"type":38},"2025-03-11",{"date":562,"type":20},"2025-03-05",{"date":564,"type":20},"2025-06-05",{"name":43,"class":44},{"id":567,"slug":568,"hasResults":11,"nctId":569,"briefTitle":570,"officialTitle":571,"acronym":4,"eligibilityCriteria":572,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":364,"enrollmentInfo":573,"targetDuration":4,"studyType":57,"phases":574,"briefSummary":575,"conditions":576,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":579,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":584,"locationsCount":4},"100575929","effectiveness-of-fentanyl-added-tap-block-in-laparoscopic-cholecystectomy-100575929","NCT06778668","Effectiveness of Fentanyl-Added TAP Block in Laparoscopic Cholecystectomy","Evaluation of the Effectiveness of Adding Fentanyl to Transversus Abdominis Plane Block in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Patients aged 18 to 70 years\n* American Society of Anesthesiologists (ASA) classification I-II-III according to the American Society of Anesthesiologists\n* Patients who provide written informed consent\n* Patients scheduled for elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Pregnancy or suspected pregnancy\n* BMI \\> 35\n* Known allergy to local anesthetics or opioids\n* Suspected coagulopathy or infection at the injection site\n* Severe neurological, psychiatric, cardiovascular, liver, or renal failure\n* Patients converted to open surgery intraoperatively",{"count":307,"type":20},[59],"The aim of this study is to evaluate the effectiveness of adding fentanyl to the TAP block in laparoscopic cholecystectomy cases. It is hypothesized that the addition of fentanyl to the TAP block will enhance the quality of postoperative analgesia and prolong the duration of blockade compared to the TAP block performed with bupivacaine alone. The study aims to determine the most effective approach by comparing these two treatment methods with a control group.",[577],"Postoperative Pain, Acute","2025-01-12",{"date":580,"type":38},"2025-01-16",{"date":582,"type":20},"2025-02-10",{"date":242,"type":20},{"name":43,"class":44},{"id":586,"slug":587,"hasResults":11,"nctId":588,"briefTitle":589,"officialTitle":590,"acronym":4,"eligibilityCriteria":591,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":592,"targetDuration":4,"studyType":57,"phases":594,"briefSummary":595,"conditions":596,"keywords":599,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":603,"lastUpdatePostDateStruct":604,"startDateStruct":606,"completionDateStruct":608,"leadSponsor":610,"locationsCount":45},"100530796","comparison-of-the-efficacy-of-conventional-landmark-ultrasound-assisted-and-real-time-ultrasound-guided-techniques-in-spinal-anesthesia-for-obese-patients-100530796","NCT06191445","Comparison of the Efficacy of Conventional Landmark, Ultrasound-Assisted, and Real-Time Ultrasound-Guided Techniques in Spinal Anesthesia for Obese Patients","Does the Use of Ultrasound Increase Spinal Anesthesia Success for Obese Patients?: Evaluation of the Success of Spinal Anesthesia Administered with Real-Time Ultrasound-Guided, Ultrasound-Assisted and Conventional Landmark Techniques","Inclusion Criteria:\n\n* 18 years and older\n* Patients who will undergo lower extremity orthopedic surgery\n* ASA I-II-III patients\n* BMI 30 kg\u002Fm² and above\n\nExclusion Criteria:\n\n* BMI \\\u003C 30 kg\u002Fm²\n* ASA IV-V patients\n* Severe cardiovascular disease\n* Patients with a known or suspected allergy to local anesthetics\n* Contraindications of spinal anesthesia (eg, coagulopathy, puncture site infection)",{"count":593,"type":20},126,[59],"Spinal anesthesia is frequently administered using the conventional landmark technique. Ultrasound is a non-invasive and safe approach. Neuroaxial anesthesia procedures can be conducted using two different ultrasound techniques; Real-Time Ultrasound Guided (USRTG) and Ultrasound-Assisted (USAS). The primary objective of this study is to compare the successes of spinal anesthesia applications using USRTG, USAS, and conventional landmark techniques on the first attempt in obese patients undergoing orthopedic surgery.",[597,598],"Spinal Anesthesia","Ultrasound",[600,597,601,602],"Anesthesia","Obesity","Ultrasonography","2024-10-11",{"date":605,"type":38},"2024-10-16",{"date":607,"type":20},"2024-11-15",{"date":609,"type":20},"2025-08-01",{"name":43,"class":44},{"id":612,"slug":613,"hasResults":11,"nctId":614,"briefTitle":615,"officialTitle":615,"acronym":4,"eligibilityCriteria":616,"healthyVolunteers":11,"sex":16,"minAge":617,"maxAge":275,"enrollmentInfo":618,"targetDuration":4,"studyType":57,"phases":620,"briefSummary":621,"conditions":622,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":45},"100535360","the-effects-of-wearing-operation-gown-with-cartoon-characters-on-reducing-preoperative-anxiety-in-children-randomized-controlled-study-100535360","NCT06250816","The Effects of Wearing Operation Gown With Cartoon Characters on Reducing Preoperative Anxiety in Children: Randomized Controlled Study","Inclusion Criteria:\n\n* Patients who are planned to have elective orthopedic surgery\n* Patients whose American Society of Anesthesiologists (ASA) physical status classification are between 1-3\n* Patients who have approved the informed consent form\n\nExclusion Criteria:\n\n* Motor and\u002For mentally retarded patients\n* Patients with hearing-speech impairment\n* Patients whose ASA physical status classification IV-V\n* Patients who do not accept informed consent and\u002For refused to participate in the study","4 Years",{"count":619,"type":20},160,[59],"The operating room environment can be frightening for pediatric patients. Many techniques have been used to make the operating room environment less intimidating, including allowing parents to accompany part of this procedure, play therapy and various distraction strategies during the entrance to the operating room. In a survey study, it was reported that parents were expected to create hospital conditions with a more child-friendly atmosphere. In this context, it is thought that creating a warmer environment for children, including the clothes worn in the operating room, may reduce the anxiety level of children. In this study, investigators' aim was to investigate the effect of wearing an hospital gown with cartoon characters on the reduction of preoperative anxiety in children scheduled for Orthopedic surgery by in the operating room.",[623],"Anxiety, Preoperative","2024-10-03",{"date":626,"type":38},"2024-10-08",{"date":628,"type":38},"2024-02-01",{"date":630,"type":20},"2025-02-01",{"name":43,"class":44},""]