[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Unidade Local de Saúde de Coimbra, EPE\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":133},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,74,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100610816","early-doppler-assisted-mobilization-in-adults-after-acute-ischemic-stroke-100610816",false,"NCT07232498","Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke","Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke - a Randomized Clinical Trial","DOP-MOBILIZE","Inclusion Criteria:\n\n* Patients diagnosed with ischemic stroke aged 18 years or older;\n* Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours;\n* Informed consent obtained from the patient or legal representative.\n\nExclusion Criteria:\n\n* Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4;\n* Diagnosis of Transient Ischemic Attack (TIA);\n* Severe hemodynamic instability, defined as:\n* Systolic blood pressure \\\u003C 100 mmHg or \\> 220 mmHg;\n* Peripheral oxygen saturation \\\u003C 92%;\n* Heart rate \\\u003C 40 or \\> 112 beats per minute;\n* Body temperature \\> 38.5°C;\n* Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale \\\u003C 10);\n* Patients who underwent neurosurgical intervention within the past 30 days;\n* Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer);\n* Requirement for continuous monitoring or continuous intravenous drug infusion;\n* Acute deep vein thrombosis\u002Fpulmonary embolism.","ALL","18 Years",{"count":20,"type":21},1300,"ESTIMATED","INTERVENTIONAL",[24],"NA","Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.\n\nIn this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.",[27],"Arterial Ischemic Stroke",[27,29,30,31,32,33],"Early mobilization","mRS","Transcranial doppler ultrasound","Neurology","Hemodynamics","RECRUITING","2026-05-20",{"date":37,"type":38},"2026-05-26","ACTUAL",{"date":40,"type":38},"2025-06-04",{"date":42,"type":21},"2027-12",{"name":44,"class":45},"Unidade Local de Saúde de Coimbra, EPE","OTHER",3,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},"100589891","effect-of-a-structured-physical-exercise-program-on-arteriovenous-fistula-maturation-for-hemodialysis-in-chronic-kidney-disease-patients-100589891","NCT06960304","Effect of a Structured Physical Exercise Program on Arteriovenous Fistula Maturation for Hemodialysis in Chronic Kidney Disease Patients","PEFAV","Inclusion Criteria:\n\n* Age ≥ 18 years\n* AVF in the upper limb\n* No cognitive decline and ability to follow instructions\n\nExclusion Criteria:\n\n* History of previous dysfunctional ipsilateral AVF\n* History of injury\u002Fcondition causing pain or loss of function in the AVF limb\n* Musculoskeletal conditions\u002Fosteoarticular pathology (e.g., myopathy, rheumatoid arthritis)\n* Neurological conditions\u002Fcardiovascular events (e.g., stroke, peripheral neuropathy",{"count":55,"type":21},128,[24],"For patients living with Chronic Kidney Disease who are preparing to start hemodialysis, having a well-functioning arteriovenous fistula (AVF) is essential. Although the AVF is considered the best type of vascular access, its maturation process does not always go as expected-studies show that in 28% to 53% of cases, the fistula does not mature properly, making effective dialysis more difficult. There is growing interest in using physical exercise as a way to support AVF maturation. International guidelines even recommend arm exercises for this purpose. However, there is still no clear agreement on what type of exercise, how often, or how intense it should be. This study aims to evaluate whether a structured exercise program focused on the AVF arm can help improve the fistula's development and overall function.",[59],"Chronic Kidney Disease Requiring Hemodialysis",[61,62,63,64],"physical exercise","chronic kidney disease","hemodialysis","fistula maturation","2025-05-05",{"date":67,"type":38},"2025-05-07",{"date":69,"type":38},"2025-01-16",{"date":71,"type":21},"2026-06-30",{"name":44,"class":45},1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":85,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":73},"100583939","immunomodulation-during-pregnancy-100583939","NCT06882850","Immunomodulation During Pregnancy","Immunomodulation During Pregnancy Through Low-Dose Aspirin: a Hypothetical Mechanism for the Prevention of Preeclampsia?","Inclusion Criteria: - Singleton pregnancy\n\n* Patients attending prenatal consultations at the Obstetrics Service A of CHUC, with the first consultation occurring before 14 weeks of gestation\n* Gestational age determined by first-trimester ultrasound\n* Study group: Women classified as high risk for PE according to clinical\u002Fhistorical criteria and the Fetal Medicine Foundation algorithm. LDA-naïve.\n\nExclusion Criteria: Multiple pregnancy\n\n* Autoimmune diseases\n* Prior use of LDA or other immunomodulatory medication before potential recruitment\n* History of spontaneous miscarriages and\u002For medical termination of pregnancy\n* Fetal malformation",true,"FEMALE",{"count":84,"type":21},30,"30 Weeks","OBSERVATIONAL","The goal of this observational study is to learn about the effects of low dose aspirin in immunity Pregnant women taking aspirin for other reasons (preeclampsia prevention) will be studied. The main question it aims to answer is: evaluate the effect of LDA on the modulation of innate immunity cells (NK cells, monocytes, γδ T cells) and\u002For acquired immunity (B and T lymphocytes, Treg cells, Th cells).\n\nParticipants already taking intervention A as part of their regular medical care for RA will answer online survey questions about their joint pain for 5 years.",[89,90,91],"Aspirin","Pregnancy Complications","Immunology",[91,93,89,94,95],"Pregnancy","Lymphocytes","T-Lymphocytes","2025-03-15",{"date":98,"type":38},"2025-03-19",{"date":100,"type":38},"2024-02-01",{"date":102,"type":21},"2025-03-31",{"name":44,"class":45},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":4},"100548579","remote-monitoring-to-identify-worsening-heart-failure-the-remoti-hf-randomized-clinical-trial-100548579","NCT06422832","Remote Monitoring To Identify Worsening Heart Failure The REMOTI-HF Randomized Clinical Trial","Remote Monitoring To Identify Worsening Heart Failure: The REMOTI-HF Randomized Clinical Trial","REMOTI-HF","Inclusion Criteria:\n\n* Possession of an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy (CRT) device that is compatible with the HeartLogic or TriageHF algorithms.\n* Left ventricular ejection fraction at the time of device implantation must be equal to or less than 35%.\n\nExclusion Criteria:\n\n* Younger than 18 years old or older than 85 years old.\n* Unable to be contacted when out of the hospital.\n* Presence of severe cognitive impairment.\n* Currently on the heart transplant waiting list","85 Years",{"count":114,"type":21},270,[24],"Heart failure, characterized by high mortality and morbidity rates, frequent hospital admissions, and prolonged stays in cardiology wards, significantly impacts patients' quality of life.\n\nThe REMOTI-HF is a single-center randomized controlled trial designed to assess the impact of remote monitoring, utilizing the HeartLogic and TriageHF algorithms, in patients with heart failure with implantable cardioverter defibrillator or cardiac resynchronization therapy. The primary endpoints include mortality, hospital admissions related to heart failure, and visits for worsening heart failure.\n\nMoreover, we will explore the full capabilities of these algorithms, by analysing the association of physical activity, measured by the devices, with the same key outcomes. Additionally, the research will explore the relationship between the absolute values provided by the algorithms and NT-proBNP values.",[118,119],"Heart Failure","Arrythmia",[118,121,122,123],"Remote Monitoring","ICD","CRT","NOT_YET_RECRUITING","2024-05-15",{"date":127,"type":38},"2024-05-21",{"date":129,"type":21},"2024-07-01",{"date":131,"type":21},"2026-07-01",{"name":44,"class":45},""]