[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":198},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,78,101,129,150,177],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644134","using-sensorimotor-reorganization-following-upper-limb-amputation-to-improve-prosthetic-control-100644134",false,"NCT07666204","Using Sensorimotor Reorganization Following Upper Limb Amputation to Improve Prosthetic Control","REINVENT","Inclusion Criteria:\n\n* people aged 18 or more\n* amputation or agenesis of one uper limb, above the wrist or higher\n* understanding of the French language and the ability to express onself in that language (for semi-structured interviews)\n* affiliation to a social security programm\n\nExclusion Criteria:\n\n* history of progressive psychiatric or neurological disorders or disorders with residual effects\n* pregnant or breastfeeding woman\n* minor\n* an adult under legal guardianship\n* pain influencing movement (trunk, residual limb, phantom limb, contralateral limb)","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","Amputation of an upper limb results in a disruption of the sensorimotor loop and a reorganization of the nervous system, leading to the emergence of a phantom limb and the adaptation of compensatory motor strategies. This project aims to leverage these phenomena (induced sensations, phantom mobility, and compensations) to improve control, sensory feedback, and the appropriation of prostheses, in order to reduce cognitive load and musculoskeletal disorders.",[26,27],"Amputation of Upper Limb","Agenesis of Upper Limb",[29,30,31],"amputation","amputation of upper limb","prosthesis","RECRUITING","2026-06-18",{"date":35,"type":36},"2026-06-24","ACTUAL",{"date":38,"type":36},"2026-04-15",{"date":40,"type":20},"2030-04-30",{"name":42,"class":43},"Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est","OTHER",2,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},"100638105","clinical-evaluation-of-the-access-socket-flexible-socket-for-transtibial-prosthesis-100638105","NCT07592325","Clinical Evaluation of the Access Socket Flexible Socket for Transtibial Prosthesis","AS-TT","Inclusion Criteria:\n\n* Unilateral or bilateral transtibial amputation\n* Currently fitted with a definitive carbon rigid socket\n* Any residual-limb shape\n* Any etiology\n* Able to understand simple instructions, read, write, and provide informed consent - or able to be accompanied by a trusted person in case of inability to read\u002Fwrite autonomously\n* Provided free written informed consent\n* Aged 18 years or older\n* Affiliated to a social security system\n\nExclusion Criteria:\n\n* Use of hydroalcoholic solution (HAS) for socket donning\n* Currently fitted with a provisional socket\n* Neurological pathology limiting capacity to participate in activities\n* Orthopedic pathology limiting capacity to participate in activities\n* Pregnant or breastfeeding women\n* Minors\n* Persons not under legal protection or unable to express consent\n* Persons under guardianship or curatorship\n* Persons under judicial protection",{"count":53,"type":20},25,[23],"Transtibial amputation significantly impacts patient autonomy and quality of life, primarily due to the limitations of conventional rigid sockets, which restrict comfort and joint range of motion. The Access Socket (AS) is an innovative prosthetic socket combining a rigid carbon-fiber structure in key load-bearing areas with flexible urethane-resin (ProtheFLEX®) zones in regions typically rigid in conventional sockets. This hybrid design aims to improve comfort and pressure distribution while preserving the mechanical properties required for ambulation.\n\nThe AS has already demonstrated benefits in transfemoral amputees and is now reimbursed in France for that population. A preliminary uncontrolled study in 12 transtibial amputees suggested significant improvements in perceived function, comfort, satisfaction, and mobility.\n\nThis multicenter, randomized, open-label, two-arm crossover study aims to compare the (AS) with the standard rigid socket (RS) in 25 adults with transtibial amputation. Participants will wear each socket for approximately 4 weeks (after a 1-2 week adaptation period) in a randomized order. The primary outcome is the Patient Specific Functional Scale (PSFS). Secondary outcomes include comfort (SCS), satisfaction (OPUS), psychosocial adjustment (TAPES-R), mobility (PLUS-M), prosthesis utility (PEQ-U), and the proportion of patients electing to keep the AS at study completion.",[57,58],"Transtibial Amputation","Lower Limb Amputation Below Knee",[60,61,62,63,64,65,66,67,68],"Transtibial prosthesis","Prosthetic socket","Flexible socket","Access Socket","Comfort","Quality of life","Rehabilitation","cross over trial","Patient Specific Scale","2026-05-13",{"date":71,"type":36},"2026-05-18",{"date":73,"type":36},"2026-04-27",{"date":75,"type":20},"2027-10-30",{"name":42,"class":43},5,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":85,"maxAge":17,"enrollmentInfo":86,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},"100540719","evaluation-of-the-effect-of-a-physical-activity-recovery-stay-100540719","NCT06320496","Evaluation of the Effect of a Physical Activity Recovery Stay","Evaluation of the Effect of a Physical Activity Recovery Stay on the Physical Condition and Quality of Life of Children in a Situation of Physical Deconditioning","Inclusion Criteria:\n\n* Children with a pathology (chronic disease, rare disease or disability) in a state of deconditioning to exercise\n* Taken in charge at the CMPRE for a stay to resume physical activity\n\nExclusion Criteria:\n\n* Age under 8 and over 18\n* Patients undergoing rehabilitation during the stay\n* Patients with a significant change in their therapeutic management during the stay\n* Significant cognitive impairment preventing comprehension of instructions\n* Significant club or leisure sports activity (3x\u002Fweek)\n* Electric wheelchair\n* Non-compliance with stay (5 ½ days missed out of total stay)\n* Participation in another study during the return-to-physical-activity stay","8 Years",{"count":19,"type":20},"OBSERVATIONAL","A WHO study in 2020 revealed that 81% of adolescents (aged 11-17) do not respect the recommendation of one hour of moderate physical activity per day. In the context of disability, many factors impose limits on physical activity. While the pathology itself induces limitations and restrictions (prolonged sitting time, assisted movement, etc.), organizational constraints also apply to both children and parents, who have to divide their time between work, school and therapeutic care, which is sometimes numerous and varied over the course of a single week. These limitations generate stress and fatigue, and prolonged sedentary periods lead children with chronic illnesses, rare diseases or disabilities into a process of physical deconditioning. The accumulation of sedentary time is detrimental to cardiovascular and metabolic health.\n\nTo combat this deconditioning, the 2008 National Physical Activity and Sport Plan (PNAPS) sets out the main guidelines for treatment and implementation. The plan explains that \"for patients with chronic illnesses, rare diseases or disabilities, the aim is to encourage care and guidance towards Adapted Physical Activity (APA). The attending physician will be able to identify local therapeutic education programs, rehabilitation services and \"sport-santé\" offers, to improve access for these patients to supervised local programs\". In addition, the plan suggests \"developing APA programs in healthcare establishments to enable people with chronic illnesses, rare diseases or disabilities to access health education incorporating practical sessions\".\n\nIn line with this plan, an exercise reconditioning program has been set up at our facility. This three-month stay includes children with a variety of pathologies, but with a common feature of physical deconditioning.",[90,91],"Children With Cerebral Palsy","Children With Cancer","2026-05-04",{"date":94,"type":36},"2026-05-08",{"date":96,"type":36},"2022-03-22",{"date":98,"type":20},"2026-09",{"name":42,"class":43},1,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":108,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":111,"conditions":112,"keywords":116,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":100},"100619788","peripersonal-space-representation-in-upper-limb-segmental-exclusion-100619788","NCT07349173","Peripersonal Space Representation in Upper Limb Segmental Exclusion","Study of the Representation of Action Peripersonal Space in Participants With Unilateral Segmental Exclusion of the Upper Limb Compared to Asymptomatic Subjects","Inclusion Criteria (patients):\n\n* Age ≥ 18 years.\n* Presenting unilateral exclusion symptom of the upper limb or part of the hand evolving for \\> 3 months.\n* No contraindication to force work in daily activities.\n* For patients with finger exclusion: at least 2 perturbed items related to exclusion on tests 3 and 4 of the \"Bilan 400 points\".\n* Affiliated to a social security scheme.\n* Able to understand simple orders.\n\nInclusion Criteria (Controls):\n\n* Age ≥ 18 years.\n* No history of upper limb impairment with sequelae.\n\nExclusion Criteria (All):\n\n* Visual impairments.\n* Central neurological pathology.\n* Unstabilized psychiatric pathology.\n* Communication or comprehension difficulties.\n* Under legal protection or unable to consent.\n* Pregnant or breastfeeding women.\n* Cervical pathology contraindicating VR headset use.\n* Epilepsy.\n* Upper limb pathology unrelated to exclusion.\n* Inability to stand for 40 minutes.",true,{"count":110,"type":20},60,"This study aims to evaluate the representation of action peripersonal space (PPS) in subjects suffering from unilateral segmental exclusion syndrome of the upper limb compared to healthy control subjects. Segmental exclusion is defined by non-use or under-use of a limb segment without central nervous system damage. The study hypothesizes that this syndrome leads to a modification (shrinkage) of the PPS representation. Participants will perform reachability judgments in a Virtual Reality (VR) environment.",[113,114,115],"Segmental Exclusion Syndrome","Complex Regional Pain Syndrome (CRPS)","Upper Limb Neglect (Peripheral)",[117,118,119,120],"Peripersonal Space","Virtual Reality","Body Schema","Reachability Judgment","2026-03-12",{"date":123,"type":36},"2026-03-16",{"date":125,"type":36},"2025-12-04",{"date":127,"type":20},"2028-01",{"name":42,"class":43},{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":108,"sex":16,"minAge":137,"maxAge":17,"enrollmentInfo":138,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":100},"100540703","analysis-of-trunk-and-center-of-mass-control-development-during-gait-in-children-with-cerebral-palsy-vertebral-100540703","NCT06320288","Analysis of Trunk and Center of Mass Control Development During Gait in Children With Cerebral Palsy (VERTEBRAL)","Analysis of Trunk and Center of Mass Control Development During Gait in Children With Cerebral Palsy","VERTEBRAL","Inclusion Criteria:\n\n* Children (\\\u003C 18 years) with cerebral palsy\n* GMFCS I to III\n* Independent walking with or without technical walking aids (walker, crutches, etc.)\n* Able to understand the instructions of various clinical assessments and functional explorations\n* Affiliated with a social security scheme\n\nExclusion Criteria:\n\nChildren with cerebral palsy\n\n* Neuro-orthopaedic surgery of the lower limbs or trunk within the last 12 months\n* Botulinum toxin A injections within the last 6 months\n* Therapeutic intervention targeting trunk control last 6 months\n\nTypically developing children\n\n* Surgery on lower limbs or trunk last 12 months\n* Neurological and\u002For orthopedic pathology that may influence gait","18 Months",{"count":139,"type":20},270,"During the acquisition of posturokinetic abilities such as walking, postural control of the trunk is of paramount importance. Indeed, its development is strongly linked to the overall motor function of children. In cerebral palsy (CP), a term that refers to a set of motor disorders following a perinatal lesion, deficits in axial control are present from early childhood. These deficits are strongly correlated with the functional deficits observed in this population. In particular, during walking, deviations of the trunk (amplitudes, accelerations) are observed in the three planes of space. While recent literature increasingly questions the impact of trunk control deficit on the walking of children with CP, elements are still missing for a holistic understanding of the interaction between locomotor and postural disorders in children with CP. In particular, no study has focused on the deviations of trunk control and the center of mass (which is a global indicator of balance strategies) during the development and maturation of walking in children with CP. Therefore, the primary objective of this cross-sectional observational study will be to characterize the development of trunk control and center of mass during walking in children with CP.",[90],"2026-01-08",{"date":144,"type":36},"2026-01-12",{"date":146,"type":36},"2023-09-20",{"date":148,"type":20},"2028-09",{"name":42,"class":43},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":108,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":21,"phases":159,"briefSummary":160,"conditions":161,"keywords":163,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":100},"100607687","uses-of-phantom-sensations-induced-by-global-and-local-modifications-of-the-prosthetic-socket-as-somatosensory-feedback-during-walking-in-lower-limb-amputees-100607687","NCT07191795","Uses of Phantom Sensations Induced by Global and Local Modifications of the Prosthetic Socket as Somatosensory Feedback During Walking in Lower Limb Amputees","PhantomWalk","Inclusion Criteria:\n\n* Participants with amputations:\n\n  * Major lower limb amputation\n  * Understand and be able to express oneself in the French language (for semi-structured interviews)\n  * Affiliated with a social security scheme\n* Asymptomatic volunteer participants:\n\n  * No major surgery on the lower limbs for at least 3 years\n  * No minor injury to the trunk, lower or upper limbs that could influence walking for at least 1 year\n  * Understand and be able to express oneself in the French language\n  * Affiliated with a social security scheme\n\nExclusion Criteria:\n\n* History of psychiatric disorders\n* Pregnant or breastfeeding woman\n* Minor\n* Adult subject to a legal protection measure\n* Person under guardianship or conservatorship\n* Person under a judicial protection order\n* Pain affecting walking (trunk, residual limb, phantom limb, contralateral limb)\n* Medical treatment incompatible with walking",{"count":158,"type":20},228,[23],"Following lower-limb amputation, the loss of somatosensory information from the missing limb renders walking less automatic, more cognitively demanding, and often asymmetric, which can lead to secondary pathologies.\n\nHypothesis: This study is based on the hypothesis that phantom limb sensations (PLS), when coherent with the prosthetic device's movements and the phases of the gait cycle, can compensate for the loss of somatosensory feedback and thereby improve locomotion for individuals with amputation. It is further hypothesized that it is possible to artificially induce these coherent and useful sensations, notably through \"referred sensations\" elicited by stimulation of the residual limb (e.g., via the prosthetic socket).\n\nObjectives: The project aims to:\n\n* Determine whether the natural presence of phantom limb sensations during walking impacts gait parameters.\n* Confirm in a larger patient population that modifications to the prosthetic socket can induce or enhance phantom sensations that are perceived as useful for walking.\n* Investigate whether these perceptual changes (induced or enhanced) are associated with objective, measurable improvements in gait quality.",[162],"Lower Limb Amputation",[164,165,166,167,168],"Phantom Limb Sensation","Referred Sensation","Somatosensory Feedback","Lower Limb Prosthesis","Prosthetic Gait","2025-09-23",{"date":171,"type":36},"2025-09-25",{"date":173,"type":36},"2024-09-16",{"date":175,"type":20},"2030-09-30",{"name":42,"class":43},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":108,"sex":16,"minAge":137,"maxAge":184,"enrollmentInfo":185,"targetDuration":4,"studyType":21,"phases":187,"briefSummary":188,"conditions":189,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":100},"100549775","trunk-activity-rehabilitation-in-young-children-with-cerebral-palsy-100549775","NCT06438432","Trunk Activity Rehabilitation in Young Children With Cerebral Palsy","Activ'Tronc","Inclusion Criteria:\n\nFor children with CP\n\n* Age between 18 months and 5 years 6 months\n* CP type: spastic paraparesis or spastic hemiparesis, GMFCS I to II\n* No or moderate retraction of the sural triceps (ankle dorsiflexion: \\> 5° on clinical examination, knee straight)\n* Sufficient level of understanding to carry out activities involving the trunk in the form of self-exercises (rehabilitation protocol), as well as clinical assessments and functional explorations.\n* Acceptance by the physiotherapist in charge of the child's follow-up to collaborate in carrying out the RAIT.\n* Affiliated with a social security scheme\n\nFor children with DT\n\n* Age between 18 months and 5 years 6 months\n* Walking acquired before age 18 months\n* Sufficient level of understanding to perform clinical assessments and functional explorations\n* Affiliated with a social security scheme\n\nExclusion Criteria:\n\nFor children with CP\n\n* Previous surgery on lower limbs less than 1 year ago\n* Botulinum toxin A injection less than 6 months ago\n* Any change in rehabilitative and\u002For orthopedic management in the last 2 months\n* Hip flessum \\> 20\n* Presence of subacute or chronic pain on standing or walking\n\nFor children with DT\n\n\\- Neurological and\u002For orthopedic disorders that may influence gait","6 Years",{"count":186,"type":20},32,[23],"Children with CP exhibit trunk control issues from early childhood, affecting their balance and gait. These issues manifest as unstable walking, increased step width, and more pronounced anterior deceleration of the sternum. Previous studies have shown that early action of the triceps surae compensates for the deficit in trunk postural control. Rehabilitation targeting the trunk has shown significant improvements in postural control and gait.\n\nThe main objective is to demonstrate that RAIT (Rehabilitation by Activities Involving the Trunk) significantly reduces the peak anterior deceleration of the sternum at the beginning of the stance phase during barefoot spontaneous walking, with an enhanced effect from prolonged RAIT duration.\n\nSecondary objectives include reducing the downward deceleration of the fifth lumbar vertebra (L5), step width, gait variability index, and improving scores on the early clinical balance scale and the global motor function evaluation.\n\nParticipants, children with spastic paraparesis or spastic hemiparesis capable of walking independently, are divided into two groups: one group continuing their usual rehabilitation for 3 months followed by RAIT for 9 months (RH-RAIT), and one group following RAIT for 12 months (RAIT-RAIT). RH involves rehabilitation exercises for lower limb muscles, while RAIT focuses on improving trunk postural control through activities involving intermediate postures.\n\nFunctional motor assessments will be conducted initially, then at 3, 6, and 12 months. These include clinical evaluations, gait analysis (step width, gait variability index, anterior foot support), and an analysis of static standing displacement using an inertial sensor placed at L5.\n\nAt M0, children with CP are expected to show higher values for deceleration peaks and gait variability indices, and lower scores on evaluation scales compared to typically developing (TD) children. After RAIT, an improvement in judgment criteria is expected: reduction in deceleration peaks, cycle width, gait variability index, anterior foot support, and an increase in scores on the ECPE and EMFG-66-SI.\n\nThis study aims to confirm that rehabilitation through trunk-involving activities is more effective than usual rehabilitation in improving postural control and gait dynamics in young children with cerebral palsy, suggesting that this approach could become a standard rehabilitation practice from early childhood.",[90],"2025-08-20",{"date":192,"type":36},"2025-08-27",{"date":194,"type":36},"2024-04-25",{"date":196,"type":20},"2026-10-31",{"name":42,"class":43},""]