[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"United States Army Research Institute of Environmental Medicine\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":191},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,40,63,90,117,145,167],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100586001","influences-of-long-acting-reversible-contraceptives-on-iron-status-and-physiological-responses-to-extreme-environments-in-women-100586001",false,"NCT06909695","Influences of Long-acting Reversible Contraceptives on Iron Status and Physiological Responses to Extreme Environments in Women","Inclusion Criteria:\n\n* • Females, age 18-40 y\n\n  * Females taking monophasic oral contraceptives or utilizing implantable contraception (intrauterine device, implantable bar) for at least one year, and be at least one year removed from the removal end point (e.g. before year 4 for a 5-year IUD)\n  * In good health as determined by OMSO (Office of Medical Support and Oversight)\n  * Passed most recent Army Combat Fitness Test (ACFT) (military volunteers only) or exercise at least 2 times per week (civilian volunteers)\n  * Willing to not drink alcoholic beverages for 24 hours before each testing session\n  * Willing to not consume caffeine 12 hours prior to any testing sessions\n  * Willing to refrain from any exercise and additional moderate to strenuous physical activity 24 hours prior to testing\n  * Willing to stay and exercise in an altitude chamber (the size of a dorm room) for \\~6 hours\n  * Supervisor approval for federal civilian employees and non-HRV active-duty military personnel stationed at NSSC.\n\nExclusion Criteria:\n\n* • Females who are pregnant, planning to become pregnant during the study, or breastfeeding.\n\n  * Taking prescription, over the counter medication, or dietary supplements, other than a contraceptive (unless approved by OMSO and Principal Investigator (PI))\n  * Tobacco or nicotine users, or anyone who has used tobacco or nicotine within the last four months\n  * Physical problems\u002Finjuries (e.g., current stress fractures, musculoskeletal strains) that would affect walking or running on a treadmill\n  * Allergy to skin adhesive\n  * Heart, lung, kidney, muscle, endocrine, or nerve disorder(s) as determined by OMSO\n  * History of heat intolerance or orthostatic intolerance\n  * Diagnosed and\u002For treated for fluid\u002Felectrolyte imbalance within the last 30 days\n  * History of obstructive disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis.\n  * Scheduled MRI within 2 weeks after completing a heat or cold test\n  * Actively dieting with the intent to lose weight\n  * History of cold injuries of any severity (e.g., frostbite, trench foot, chilblains).\n  * Raynaud's syndrome\n  * Cold-induced asthma\u002Fbronchospasm\n  * Not willing to have small areas of skin on the body shaved (if deemed necessary for attachment of study instrumentation)\n  * Born at altitudes greater than 2,100 m (7,000 ft) (e.g., Mexico City, Mexico)\n  * Living in areas that are more than 1,200 m (4,000 ft) (e.g., Colorado Springs, CO) or have traveled to areas that are more than 1,200 m for five days or more within the last 2 months\n  * Prior diagnosis of High Altitude Pulmonary Edema (HAPE) or High Altitude Cerebral Edema (HACE)\n  * Abnormal blood count in accordance with OMSO - Normal Hb women: 11.1-15.9 g·dL-1 or Normal Hct women: 34.0-48%, or presence of abnormal blood chemicals (hemoglobin S or Sickle Cell Trait)\n  * History of pneumothorax\n  * History of hypertension\n  * Blood donation within 8 weeks of beginning the study\n  * Any recent (within 4-6 weeks) and or expected history of prolonged periods of immobility or limited activity (including recent or upcoming surgery)\n  * Evidence of apnea or sleeping disorder (narcolepsy, insomnia, etc.)",true,"FEMALE","18 Years","40 Years",{"count":20,"type":21},33,"ESTIMATED","OBSERVATIONAL","Over recent years, military service women have shown increasing interest in utilizing long-acting reversible contraceptives (LARCs; i.e., implants or intrauterine devices, IUDs). While clinically, LARC have been proven safe and effective at preventing pregnancy \\& decreasing menstrual symptoms, it is unclear what impact this type of contraceptive may have on physiological responses to extreme environments (heat, cold and high altitude). Additionally, iron deficiency and iron deficiency anemia are prevalent in U.S. military women which likely affect health and performance. There is evidence to suggest that the prevalence of iron deficiency and iron deficiency anemia is lower in women utilizing LARCs, which preserve iron stores, likely due to reduced menstrual blood loss that compounds with each cycle over the course of months. Due to the increasing interest in the utilization of LARCs it is important to understand what, if any, impact these methods of contraception may have on a female Soldier's physiological responses.\n\nThe overall goal of the present study is to characterize iron status and physiological responses (including but not limited to sweating, skin blood flow, ventilation, and heart rate) to extreme environmental stressors of heat, cold and high altitude (i.e. hypobaric hypoxia) in women utilizing LARCs. Up to thirty-three individuals (n=18 LARCs, n=15 monophasic oral contraceptives) will complete testing visits separated by at least 48 hours for environmental testing visits. During heat stress testing, measures of core body temperature, skin temperature, and sweat rate will be measured during a standardized protocol in hot, humid conditions. During cold stress, measures of body core temperature, metabolic heat production, skin blood flow and temperature (at both distal extremity and proximal body sites) will be assessed in order to better quantify the impact of exogenous sex hormones via LARCs and OCs in volunteers exposed to the cold. Measurements will be obtained during a standardized protocol in cold air (\\~90 min; 10°C). For altitude, cardiopulmonary responses will be assessed during rest and exercise during an acute altitude exposure (4300m). Blood samples will be collected throughout the investigation in order to quantify sex hormone concentrations, iron status, and inflammatory biomarkers in response to environmental stressors. The investigators will also utilize laboratory tests (i.e., carbon monoxide (CO) rebreathing technique) and collect blood samples to quantity iron stores in these groups of women. To characterize iron status, the Soldier Performance Health and Readiness (SPHERE) epidemiological data repository will be utilized to quantify the prevalence of iron deficiency and iron deficient anemia diagnoses between women using LARCs and women not utilizing LARCs.",[25,26],"Contraception","Iron Deficiencies","RECRUITING","2026-04-29",{"date":30,"type":31},"2026-04-30","ACTUAL",{"date":33,"type":31},"2024-11-01",{"date":35,"type":21},"2027-09",{"name":37,"class":38},"United States Army Research Institute of Environmental Medicine","FED",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":15,"sex":46,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":62},"100585811","physiological-responses-to-heat-stress-during-high-risk-events-100585811","NCT06907225","Physiological Responses to Heat Stress During High-risk Events","Inclusion Criteria:\n\n* Individuals (to include cis- and transgender males and females and nonbinary) 18 years of age or greater\n* Current military service (active, Reserve, or National Guard)\n* Currently participating in training\n\nExclusion Criteria:\n\n* Females who are pregnant\n* Any individual currently on a physical profile that restricts running or foot marching\n* History of obstructive disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis.\n* Scheduled MRI within 2 weeks after core temp pill ingestion\n* Known allergies to skin adhesive\n* Blood donation in the past 8 weeks","ALL",{"count":48,"type":21},150,"Exertional heat stroke (EHS) affects \\~500 Military Personnel and over 100 Soldiers every year, and it is believed that these numbers are underreported. EHS is the most severe form of exertional heat illness (EHI) and can result in substantial, long-lasting organ damage, and even death in severe cases. Based on current knowledge and training needs, it is impossible to prevent every EHS - which shifts the focus from exclusively prevention to a combination of prevention, treatment, and enhancing recovery as much as possible. While many risk factors have been identified and there are adequate treatments available, biomarkers associated with heat stroke risk, recovery, and return-to-duty (RTD) remain largely unclear. The purpose of the proposed study is to enhance knowledge surrounding biomarkers of EHS and long-term health consequences that result from EHS. The investigators will recruit research volunteers for a field study in order to collect pre-, post-, and follow-up measures from a high-risk EHS event (i.e. ruck marches, timed runs) this will allow us to have a basis for comparison between Soldiers who collapse with EHS (from previously collected data) and those that complete high-risk events, but do not collapse. This will allow for comparison between the groups to identify EHS-specific biomarkers that could aid in recovery and RTD decisions for Soldiers.",[51],"Thermoregulation",[51,53],"Heat illness","2026-04-28",{"date":56,"type":31},"2026-05-05",{"date":58,"type":31},"2025-05-31",{"date":60,"type":21},"2026-09",{"name":37,"class":38},2,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":15,"sex":46,"minAge":17,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":39},"100630593","energy-dense-fueling-for-cold-weather-operations-100630593","NCT07489690","Energy Dense Fueling for Cold-Weather Operations","Inclusion Criteria: • Men and women aged 18 - 39 years (17 if active Military)\n\n* Physically active (exercise minimum 2 days per week)\n* Have supervisor approval (permanent party military and civilians at NSSC)\n* Willing to refrain from alcohol, nicotine products and dietary supplement use while on study diets\n* Females must have normal menstrual cycles between 26-32 days in duration; 5 menstrual cycles within the past 6 months; or using oral\u002Fhormonal contraceptive which contains low-dose estrogen\u002Fprogesterone to maintain continuous levels throughout the 28-day cycle (i.e., no placebos)\n* Only consume caffeine products while on study diets if provided by study staff\n* Body mass index (BMI) between 18.5-30 kg\u002Fm2\n* In good health as determined by OMSO (Office of Medical Support and Oversight)\n\nExclusion Criteria:\n\n* Metabolic or cardiovascular abnormalities, gastrointestinal disorders (i.e., kidney disease, diabetes, cardiovascular disease, hypertension etc.) that is unsuitable for the study determined by OMSO\n* Disease or medication (i.e., diabetes medications, statins, corticosteroids, etc) that affects macronutrient utilization and\u002For the ability to participate in strenuous exercise\n* Allergies or intolerance to foods (including but not limited to lactose intolerance\u002Fmilk allergy), vegetarian practices\n* Present condition of alcoholism, anabolic steroids (testosterone, enanthate, undecanoate, etc), or other substance abuse issues\n* Unwilling to stop use of nutritional\u002Fsports supplements (creatine, multivitamins, whey etc.) while enrolled in the study\n* Sensitivity to medical adhesives resulting in significant skin irritation\n* Acute or chronic musculoskeletal injury that compromises the ability to run and ruck march\n* History of disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis; or previous gastrointestinal surgery\n* Difficulty swallowing large pills or unwilling to insert rectal temperature sensor\n* Raynaud's syndrome.\n* History of cold injuries of any severity (e.g., frostbite, trench foot, chilblains) that puts the volunteers at increased risk for an adverse effect\n* Cold-induced bronchospasms\u002Fasthma\n* Blood donation within 8 weeks of the study\n* Unwillingness or inability to adhere to study exercise restrictions\n* Scheduled MRI within 2 weeks after completing test in cold","39 Years",{"count":71,"type":21},8,"INTERVENTIONAL",[74],"NA","High daily energy expenditures without compensatory increases in energy intakes results in severe energy deficits during cold-weather military operations. Observational and experimental data from our laboratory suggests that consuming higher-fat, energy dense products can increase energy intake and attenuate energy deficits, however, laboratory analysis is needed to understand the impact of macronutrient manipulation on substrate oxidation and aerobic performance. This proof of concept, randomized crossover study will examine the effects of consuming an isocaloric bar (approximately 350 kcal) that is higher in carbohydrate (CHO: 50% carbohydrate, 30% fat, 20% protein) or higher in fat (FAT: 30% carbohydrate, 50% fat, 20% protein) on substrate oxidation and aerobic performance (time trial) during acute cold (5°C) exposure. Volunteers will wear shorts and a t-shirt during cold exposure, with continuous monitoring of core and skin temperatures. Baseline data will be collected on volunteer height, weight, body composition, and V̇O2peak. To ensure volunteers are familiar with exercise protocols, they will complete practice sessions of all exercise before the start of data collection. Exercise and diet will be controlled throughout data collection. 24 hours prior to data collection, volunteers will consume a lead-in study diet and will abstain from exercise. After 24 hours, volunteers will return to the laboratory for assessment of substrate oxidation and aerobic performance. Volunteers will consume the CHO or FAT treatment bars under cold conditions, followed by 60 minutes of rest prior to the start of exercise. Volunteers will then complete 90 minutes of load carriage steady-state (55 ± 5% VO2peak) treadmill exercise, wearing a ruck with weighing 30% of their total body mass. After steady-state exercise, aerobic performance will be assessed by having volunteers complete a 2-mile time trial. Indirect calorimetry will be used to determine substrate oxidation during steady-state exercise. Serial blood draws will be collected during each trial to assess circulating substrate\u002Fhormone responses. Protocol days will be separated by a minimum washout period of 6 days.",[77],"Cold Exposure",[79,80,81],"endurance exercise","dietary fat","dietary carbohydrate","2026-03-18",{"date":84,"type":31},"2026-03-24",{"date":86,"type":31},"2026-02-14",{"date":88,"type":21},"2026-09-30",{"name":37,"class":38},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":15,"sex":46,"minAge":97,"maxAge":69,"enrollmentInfo":98,"targetDuration":4,"studyType":72,"phases":100,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":39},"100597798","bioavailability-of-ration-items-containing-tart-cherry-extract-100597798","NCT07063173","Bioavailability of Ration Items Containing Tart Cherry Extract","Tart Cherry","Inclusion Criteria:\n\n* Active duty military personnel and civilians will be invited to participate in the study if they:\n\n  * Are between the ages of 18 (or 17 for military personnel) and 39.\n  * Are willing to participate in all study procedures and comply with all study instruction.\n  * In good health as determined by OMSO (Office of Medical Support and Oversight).\n  * Supervisor approval for federal civilian employees and non-HRV active-duty military personnel stationed at NSSC\n\nExclusion Criteria:\n\n* • Unable to understand verbal or written instructions or testing materials in English.\n\n  * Have a bleeding disorder (e.g., von Willebrand Disease, hemophilia) or are being treated with medication that will impair blood clotting (for example, coumadin)\n  * Have a history of GI-related conditions that may impact macronutrient absorption (e.g., Crohn's disease, ulcerative colitis, Celiac's disease or gluten sensitivity, bariatric surgery or gastroparesis, short bowel, inflammatory bowel disease, etc…);\n  * Any use of antibiotics or antifungal, except topical antibiotics\u002Fantifungals within 3 months of study participation.\n  * Colonoscopy within 3 months of study participation.\n  * Regular (i.e., weekly or more frequent) use of over-the-counter medications (including antacids, laxatives, stool softeners, and antidiarrheals) unless approved by OMSO and study PI.\n  * Are habitually taking nonsteroidal anti-inflammatory drugs (e.g., Advil, aspirin), corticosteroids (e.g., prednisone) or immunosuppressants (e.g. Humira);\n  * Have an allergy or aversion (extreme dislike) to any of the test foods(e.g., cherry flavored beverages or bar). Allergy symptoms may include anaphylaxis, hives or eczema, tingling\u002Fitching in the mouth, dizziness or fainting, diarrhea, nausea or vomiting, swelling of the lips, face, tongue and throat).\n  * Have donated blood within the past 8 weeks of the first test session or plan to donate blood during the study.\n  * Are not willing to abstain from tobacco products and vigorous exercise for at least 24 hours\" before each trial and consume a low-polyphenol diet two days prior to each test session and on the day of the test session.","17 Years",{"count":99,"type":21},15,[74],"To determine how consuming food items containing shelf-stored tart cherry impacts your body's ability to absorb and use the compounds within tart cherry.",[103],"Bioavailability",[105,106,107,108],"military","tart cherry","muscle recovery","polyphenols","2025-12-19",{"date":111,"type":31},"2025-12-29",{"date":113,"type":31},"2024-06-14",{"date":115,"type":21},"2025-12-31",{"name":37,"class":38},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":15,"sex":46,"minAge":97,"maxAge":69,"enrollmentInfo":124,"targetDuration":4,"studyType":72,"phases":126,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":144,"locationsCount":39},"100598279","muscle-response-to-different-amounts-of-dietary-protein-during-leg-immobilization-100598279","NCT07069426","Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization","The Effects of Varying Protein Intakes on Muscle Protein Synthesis During Injury-Mediated Muscle Disuse","Inclusion Criteria:\n\n* Men and women aged 18-39 years (17-39 years if military personnel)\n* Body mass index (BMI) between 18.5-32 kg\u002Fm2\n* Routinely participate in aerobic and\u002For resistance exercise at least 2 days per week.\n* Willing to refrain from alcohol, smoking, smokeless nicotine products (includes e-cigarettes, vaping, chewing tobacco), and dietary supplements (i.e., vitamin D, probiotics) 24 hours before and during immobilization and final testing day.\n* Willing to only consume caffeine products provided by study staff during the study.\n* Supervisor approval for federal civilian employees and non-SRV active-duty military personnel stationed at NSSC.\n* Biological females must have normal menstrual cycles between 26-32 days in duration; 5 menstrual cycles within the past 6 months; or on continuous hormonal contraception (i.e., IUD or oral contraceptives without placebo).\n\nExclusion Criteria:\n\n* Musculoskeletal injuries that may interfere with the safe use of crutches.\n* Personal or family history of thrombosis, or prior diagnosis of deep vein thrombosis (DVT) or pulmonary embolism (PE).\n* Metabolic or cardiovascular abnormalities, gastrointestinal disorders, neuromuscular disorders, lower-limb amputation, or muscle\u002Fbone wasting disorders (e.g., diabetes, cardiovascular disease, Crohn's disease, etc.).\n* Taking medication that affects macronutrient utilization (i.e., statins, corticosteroids, weight loss medications such as Ozempic, etc.).\n* Significantly abnormal blood clotting as determined by USARIEM Office of Medical Oversight (OMSO) or home duty station medical support (HMS).\n* Allergy to lidocaine (or similar local anesthetic).\n* Present condition of alcoholism, anabolic steroid use, or other substance abuse issues as determined by OMSO or HMS.\n* Blood donation within 8-wk of beginning the study.\n* Pregnant, trying to become pregnant, and\u002For breastfeeding (results of urine pregnancy test and self-report for breastfeeding will be obtained before body composition testing).\n* Unwilling or unable to consume study diets or foods provided due to personal preference and\u002For food allergies.\n* Unwilling or unable to adhere to study physical restrictions (i.e., no structured physical activity or recreational activity beyond activities of daily living) 24 hours before and during immobilization, and the final testing day.\n* Unwilling or unable to keep the knee brace on and walk with crutches during the immobilization phase.",{"count":125,"type":21},28,[74],"Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy). Loss of muscle under these conditions is attributed to a persistent negative net muscle protein balance (muscle protein synthesis \\[MPS\\] \\\u003C muscle protein breakdown) that results, in part, from declines in postprandial MPS (i.e., anabolic resistance). Nutritional interventions that enhance postprandial MPS may be used to overcome disuse-induced anabolic resistance and preserve muscle mass to accelerate recovery and improve recovery outcomes. While supplemental protein has been explored as a potential countermeasure to disuse-induce anabolic resistance, the observed efficacy of such interventions has been mixed. Equivocal findings across studies may be attributed, in part, to an insufficient understanding of what constitutes an effective protein-based intervention. Importantly, no study to date has determined an optimal protein dose for overcoming disuse-induce anabolic resistance, or if there is a threshold for maximally stimulating postprandial MPS under disuse conditions. Therefore, the objective of this work is to determine rates of MPS at rest and in response to standard (20 g) or high (40 g) doses of whey protein during knee immobilization (DISUSE) compared with standard activity (ACTIVE)",[129,130],"Muscle Disuse","Muscle Disuse Atrophy",[132,133,134,135,136,137],"muscle protein synthesis","muscle disuse","muscle disuse atrophy","immobilization","anabolic resistance","dose-response","2025-09-04",{"date":140,"type":31},"2025-09-11",{"date":142,"type":31},"2025-09-01",{"date":60,"type":21},{"name":37,"class":38},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":15,"sex":46,"minAge":17,"maxAge":18,"enrollmentInfo":152,"targetDuration":4,"studyType":72,"phases":154,"briefSummary":156,"conditions":157,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":39},"100568858","phase-4-intravenous-iron-effects-on-performance-at-high-altitude-100568858","NCT06686693","Intravenous Iron Effects on Performance at High Altitude","Intravenous Iron Prophylaxis for Rapid High Altitude Insertions","Inclusion Criteria:\n\n* Man or woman, age 18-40 years\n\n  * BMI 18.5-30 kg\u002Fm2\n  * In good health as determined by the Office of Medical Support \\& Oversight (OMSO) General Medical Clearance\n  * Passed his\u002Fher most recent Army Combat Fitness Test (ACFT) (Military Volunteers Only) or exercises at least 2 times per week and able to complete two mile run in ≤ 21 minutes (Civilian Volunteers)\n  * Willing to not exercise, or drink alcoholic\u002Fcaffeinated beverages 24 hours prior to each testing session\n  * Willing to not perform any strenuous exercise 36 hours prior to each testing session\n\nExclusion Criteria:\n\n* Women who are pregnant or planning to become pregnant during the study\n\n  * Taking prescription medication, or over-the-counter medications other than contraceptives, unless approved by OMSO \\& PI\n  * Taking dietary supplements unless approved by OMSO \\& PI\n  * Born at altitudes greater than 2,100 m (7,000 ft)\n  * Living in areas that are more than 1,200 m (4,000 ft) or have traveled to areas that are more than 1,200 m for five days or more within the last 2 months\n  * Prior diagnosis of High Altitude Pulmonary Edema (HAPE) or High Altitude Cerebral Edema (HACE)\n  * Musculoskeletal injuries that compromise the ability to walk\u002Frun on a treadmill\n  * Presence of abnormal blood chemicals (hemoglobin S or Sickle Cell Trait)\n  * Hemoglobin concentration: men: Hb \\\u003C13.5 g\u002FdL or Hb \\>17.7 g\u002FdL; women Hb \\\u003C12.5 g\u002FdL or Hb \\>15.9 g\u002FdL\n  * Ferritin \\\u003C 50 ng\u002FmL or greater than 150 ng\u002FmL\n  * Any history of malignancy\n  * Personal or family history of blood clots\n  * History of thromboembolic disease, hypertension, and known risk factors of cardiovascular disease\n  * Blood donation within 8 weeks of beginning the study\n  * History of seizures\n  * History of inflammatory bowel disease\n  * Any recent (within 4-6 weeks) and or expected history of prolonged periods of immobility or limited activity (including recent or upcoming surgery)\n  * Abnormal PT\u002FPTT test or problems with blood clotting\n  * Any nicotine or recreational drug use (unless quit \\> 1 month prior to study orientation)\n  * Presence of respiratory tract infections (\\\u003C 1 month prior)\n  * Experience recent cold, coughs, or sinus infections (\\\u003C 2 weeks prior)\n  * Allergy to skin adhesive\n  * Evidence of apnea or sleeping disorder\n  * Present condition of alcoholism, use of anabolic steroids, other substance abuse issues\n  * Body mass \\\u003C50 kg (110.5 lbs)\n  * History of hyperparathyroidism\n  * History of vitamin D deficiency\n  * History of systemic inflammatory disease (rheumatoid arthritis, lupus erythematosus)\n  * Any drug allergies\n  * History of hypersensitivity reaction\n  * History of asthma\n  * History of kidney or liver disease\n  * Any previous intravenous iron injection",{"count":153,"type":21},24,[155],"PHASE4","To compare the effects of IV iron versus placebo (saline) injection on arterial oxygen saturation, submaximal exercise responses, and 2-mile treadmill time-trial performance during acute exposure to hypobaric hypoxia (430 mmHg, simulating \\~4800m) assessed 1 and 14 days after treatment.\n\nPrimary Hypothesis 1: IV iron treatment will improve arterial oxygen saturation at rest and during exercise in acute hypobaric hypoxia and this effect will persist for 2 weeks\n\nPrimary Hypothesis 2) IV iron treatment will improve 2-mile treadmill time trial performance in acute hypobaric hypoxia and this effect will persist for 2 weeks",[158],"Hypoxia","2025-03-25",{"date":161,"type":31},"2025-03-30",{"date":163,"type":31},"2022-04-15",{"date":165,"type":21},"2025-09-30",{"name":37,"class":38},{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":15,"sex":46,"minAge":97,"maxAge":69,"enrollmentInfo":174,"targetDuration":4,"studyType":72,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":182,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":39},"100576380","the-effects-of-repeated-operational-stress-and-limited-recovery-on-resilience-capacity-100576380","NCT06784544","The Effects of Repeated Operational Stress and Limited Recovery on Resilience Capacity","REP DEF","Inclusion Criteria:\n\n* Men and women aged 18 - 39 years (17 - 39 years if military personnel)\n* Weight stable in the past 2 months (± approximately 5 kg)\n* Healthy without evidence of chronic illness or musculoskeletal injury as determined by the USARIEM Office of Medical Support and Oversight (OMSO) or home duty station medical support (HMS)\n* Functional exercise (i.e., step ups, box jumps, body mass movements) and\u002For aerobic exercise trained defined by self-report as performing ≥ 2 sessions\u002Fwk for previous 6 months\n* Willing to refrain from alcohol, smoking any nicotine product (includes e-cigarettes); vaping, chewing tobacco, caffeine not provided in the study, and dietary supplement use throughout the dietary interventions\n* Biological females must be on sustained (i.e., approximately \\>3 months) oral\u002Fhormonal contraceptive use which acts to maintain continuous hormonal levels (i.e., contains low-dose estrogen\u002Fprogesterone with no oral placebos, hormonal IUD)\n* Supervisor approval for federal civilian employees and non-HRV active duty military personnel)\n\nExclusion Criteria:\n\n* Musculoskeletal injuries that compromise exercise capability as determined by OMSO or HMS\n* Metabolic or cardiovascular abnormalities, sleep disorders (i.e., sleep apnea) gastrointestinal disorders (e.g., kidney disease, diabetes, cardiovascular disease, etc.) as determined by OMSO or HMS\n* Abnormal or problems with blood clotting as determined by OMSO or HMS\n* History of complications with lidocaine or similar local anesthetic analogue\n* Present condition of alcoholism, anabolic steroids, or other substance abuse issues\n* Blood donation within 8-wk of beginning or completing study blood draws\n* Current diagnosis of Anemia (hemoglobin \\\u003C 13 g\u002FdL for males, hemoglobin \\\u003C 12 g\u002FdL for females) and Sickle Cell Anemia\u002FTrait as determined by OMSO or HMS\n* Pregnant, trying to become pregnant, and\u002For breastfeeding (results of urine pregnancy test or self-report for breastfeeding will be obtained before body composition testing)\n* Claustrophobia or discomfort related to having enclosed equipment around the head\n* Unwillingness or inability to consume study diets or foods provided due to personal preference or food allergies\u002Fsensitivities\n* Unwillingness or inability to adhere to study exercise restrictions and prescriptions",{"count":153,"type":21},[74],"This longitudinal study will examine the effects of repeated bouts of operational stress and limited recovery on integrated MPS, whole-body protein balance, iron absorption, and aerobic performance. Following baseline characterization measures, active adults (n=24) representative of normal weight phenotype (NW; n=12) and overweight phenotype (OW; n=12) will complete a 48h balance phase preceding two rounds of repeated 72h energy deficit exposure each immediately followed by a 48h recovery phase. NW cutoff will be defined ≤ 22% body fat for males and ≤ 32% body fat for females. OW cutoff will be defined as \\>22% body fat for males and \\>32% body fat for females. These body composition cutoffs are informed by the maximum allowable percent body fat standards outlined in current Army Regulation 600-9. Additional details for determining % body fat are outlined in the experimental procedures section of the protocol.",[178,179,180,181],"Sleep, Inadequate","Energy Deficit","Iron Absorption","High Physical Activity","NOT_YET_RECRUITING","2025-01-14",{"date":185,"type":31},"2025-01-20",{"date":187,"type":21},"2025-05",{"date":189,"type":21},"2025-11",{"name":37,"class":38},""]