[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"United States Naval Medical Center, San Diego\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":137},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,82,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100594584","auricular-acupuncture-on-emotional-distress-in-service-members-and-veterans-with-ptsd-100594584",false,"NCT07021352","Auricular Acupuncture on Emotional Distress in Service Members and Veterans With PTSD","Effects of Auricular Acupuncture on Emotional Distress in Service Members and Veterans With Posttraumatic Stress Disorder","Inclusion Criteria:\n\n* Active duty service member and veterans\n* A score of 14 or above on the abbreviated PCL 6-item\n* A score of 24 or above on the EDS\n* Agrees to participate in mindfulness therapy\n* Able to provide informed consent\n\nExclusion Criteria:\n\n\\- Has had mindfulness therapy received from a healthcare provider in the past month","ALL","18 Years","65 Years",{"count":20,"type":21},66,"ESTIMATED","INTERVENTIONAL",[24],"NA","Emotional distress (ED) refers to a state of mental suffering that significantly impairs an individual's ability to cope, often leading to a decline in overall well-being. In military contexts, ED is a prevalent concern due to the unique and demanding challenges faced by military personnel both in combat zones and during peacetime. The primary objective of this study is to assess the efficacy of integrating ear acupuncture with mindfulness therapy in mitigating ED and alleviating post-traumatic stress disorder (PTSD) symptoms among military personnel. The study will examine the effects of auricular acupuncture (AA) and mindfulness therapy (MT) on ED in military personnel with PTSD. The NADA ear acupuncture protocol will be administered using acupuncture semi-permanent (ASP), sterile needles placed in the bilateral ears, which will remain in place until they naturally fall out. Mindfulness therapy will incorporate relaxation techniques, such as yoga and controlled breathing exercises, specifically designed to alleviate ED. A mixed-methods approach, integrating both quantitative and qualitative methods, will be employed concurrently to evaluate the interventions' effectiveness and to explore the participants' perceived benefits. Specific Aim 1: To evaluate the effectiveness and perceived benefits of the National Acupuncture Detoxification Association (NADA) ear acupuncture protocol as an adjunct therapy to brief mindfulness therapy for reducing emotional distress in service members and veterans with PTSD. Specific Aim 2: To examine the effectiveness of NADA as an adjunct therapy to brief mindfulness therapy in improving sleep disturbances, alcohol use, and pain in service members and veterans with PTSD.",[27,28],"PTSD and Substance Use Disorder","Emotional Distress","RECRUITING","2026-04-21",{"date":32,"type":33},"2026-04-24","ACTUAL",{"date":35,"type":33},"2026-03-02",{"date":37,"type":21},"2028-06",{"name":39,"class":40},"United States Naval Medical Center, San Diego","FED",2,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":67,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":41},"100547838","remotely-supervised-tdcs-for-complex-attention-in-mtbi-cognetric-100547838","NCT06413173","Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)","Remotely Supervised tDCS Combined With Cognitive Training to Improve Complex Attention in Active Duty Service Members and Veterans With Mild TBI (Cognetric)","COGNETRIC","Inclusion Criteria:\n\n1. Active-Duty Service Members.\n2. Ages 18 to 60.\n3. All genders.\n4. All racial and ethnic groups.\n5. History of mild TBI (as defined by the DOD\u002FVA criteria used in conjunction with the OSU TBI-ID) sustained at least 3 months and no more than 10 years prior to enrollment.\n6. Self-reported attention and\u002For concentration difficulties.\n7. At least one cognitive symptom reported on the Neurobehavioral Symptom Inventory (NSI) cognitive subscale.\n\nExclusion Criteria:\n\n1. Presence of a medical, psychiatric, physical or non-physical disease, disorder, condition, injury, disability or pre-existent history such that study participation, in the opinion of the PI: (a) may pose a significant risk to the participant; (b) raises the possibility that the participant is unlikely to successfully complete all of the requirements of the study according to the study protocol; or (c) might adversely impact the integrity of the data or the validity of the study results. Specific conditions include (but are not limited to) a history of: brain tumor, epilepsy, cerebral vascular accident (CVA), Schizophrenia, Bipolar Disorder, and Mania.\n2. History of prior treatment with ECT or neuromodulation in the last 12 months.\n3. Current, diagnosed substance dependence.\n4. Newly prescribed medication within the previous 3 weeks.\n5. Diagnosis of intellectual disability or pervasive developmental disorder (i.e., premorbid IQ less than or equal to 70).\n6. Any medical condition or treatment other than mild TBI (e.g., stroke, tumor, HIV, moderate-severe TBI), with significant neurological disorder or insults that, based on the Principal Investigator's judgment, would impact risk.\n7. Psychosis or mania within 30 days of enrollment, as determined by the PI, based on a psychiatric history and examination and\u002For a review of available medical records\n8. Contraindications for tDCS (e.g., metallic cranial plates\u002Fscrews or implanted device, eczema or skin lesions on scalp)\n9. A positive pregnancy report.","60 Years",{"count":52,"type":21},160,[24],"The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called \"Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training\" (RS-tDCS+) which has shown promise for improving complex attention in both healthy and clinical populations. RS-tDCS+ is a home-based, low-risk, non-invasive technique that is designed to boost cognitive training by enhancing learning and the brain's ability to reorganize connections. This study will evaluate RS-tDCS+ for improving complex attention in Active Duty Service Members (ADSM) and Veterans with a history of mTBI. Different tests of complex attention and symptom questionnaires will be used to determine the effects of real versus sham (placebo) RS-tDCS+. Second, the investigators will investigate electrical and connectivity changes in the brain associated with RS-tDCS+ using electroencephalogram (EEG) and magnetic resonance imaging (MRI). Third, the investigators will investigate the lasting effects of any observed changes by evaluating participants at 1 and 6 weeks post-treatment. Lastly, the investigators will explore the impact of individual differences (e.g., PTSD, depression, sleep quality, time since injury, baseline impairment, age, sex, ADSM versus Veteran) on treatment outcome.",[56,57,58,59,60,61,62,63,64,65,66],"Brain Concussion","Brain Trauma","Attention Concentration Difficulty","Brain Injuries","Brain Injuries, Traumatic","Neurocognitive Dysfunction","Attention Impaired","Memory Impairment","Mild Traumatic Brain Injury","Mild Cognitive Impairment","Post Concussive Symptoms",[68,69,70,71,72,73],"Military Health","Brain Stimulation","Cognitive Training","Cognitive Rehabilitation","Telehealth","Neuromodulation","2025-11-07",{"date":76,"type":33},"2025-11-12",{"date":78,"type":33},"2024-07-25",{"date":80,"type":21},"2028-09-30",{"name":39,"class":40},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":16,"minAge":17,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":97,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},"100559205","treatment-optimization-of-brain-injured-warfighters-100559205","NCT06561100","Treatment Optimization of Brain-injured Warfighters","Treatment Optimization of Brain-injured Warfighters: A Prescribed Sub-symptomatic Exercise Treatment","(TOBI-SET)","Inclusion Criteria:\n\n* Active duty, male or female, ages 18 to 55\n* History of at least one mTBI sustained more than 1 month ago\n* Service members (SMs) with ongoing symptoms\n\nExclusion Criteria:\n\n* SMs who sustained a TBI of any severity within 1 month of enrollment\n* History of moderate, severe, or penetrating TBI\n* Current substance use disorder\n* History of a neurological disease (e.g., multiple sclerosis, cerebral vascular accident, brain tumor, neurodegenerative disease, or neuro-motor disorder)\n* An acute orthopedic injury that limits the capacity to complete study procedures",true,"55 Years",{"count":93,"type":21},140,[24],"Prescribed sub-symptomatic adaptable exercise treatment (SAET) is a potential solution that promotes recovery needs following a TBI. SAET has been shown to benefit the mind and body in ways that decrease the severity and frequency of mild TBI (mTBI) symptoms. This study aims to validate SAET as an alternative, adaptable treatment or SMs with mTBI that focuses on reducing symptoms, improving mental health, increasing physiological functioning, and ultimately returning to duty.\n\nThe objective of this study is to develop a prescribed exercise treatment program for warfighters with mTBI that can be personalized for SM's needs (i.e., medical and occupational) and is adaptable to various clinical resources (e.g., forward operating bases, rural clinics, and mTBI specialty programs). The key question raised by this study is whether SAET is more effective than a stretching control group (SCG) in reducing neurobehavioral symptoms among SMs with persistent complaints following a mTBI.",[64],[98,99],"Progressive Return to Activity","Warfighter Readiness","2024-08-16",{"date":102,"type":33},"2024-08-19",{"date":104,"type":33},"2023-09-27",{"date":106,"type":21},"2026-09",{"name":39,"class":40},1,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":108},"100557284","efficacy-of-a-criteria-based-clinical-pathway-for-rehabilitation-of-shoulder-injuries-100557284","NCT06536114","Efficacy of a Criteria Based Clinical Pathway for Rehabilitation of Shoulder Injuries","CRISP","Inclusion Criteria:\n\n* Active-duty Service members over the age of 18 who are seeking medical attention for shoulder pain or injury will be recruited to participate in this study.\n\nExclusion Criteria:\n\n* The exclusion criteria include individuals who have sustained cervical or thoracic spine injury in the past year; an upper extremity or spine injury within the past year and have not been cleared to perform their previous duty requirements; a diagnosis of adhesive capsulitis; individuals referred to post-operative rehabilitation for the shoulder; individuals who are scheduled for shoulder surgery within the following 12 weeks; pain originating from a body region other than shoulder or is non-orthopaedic in nature; individuals who have sustained an upper extremity limb loss; individuals pending a medical evaluation board, discharge from the military, or pending litigation for an injury.",{"count":117,"type":21},250,[24],"The goal of this clinical trial is to compare the current standard of care for rehabilitation of non-operative shoulder injuries to a novel, criteria-based approach (CRISP). Additionally, this study will identify factors which contribute to return to duty readiness. The main questions it aims to answer are:\n\n* Are there differences in patient reported outcomes between participants who undergo the criteria-based rehabilitation program versus the standard of care for shoulder injuries?\n* Are there differences in clinical measures (strength, etc.) between participants who undergo the criteria-based rehabilitation program versus the standard of care for shoulder injuries?\n* Are there clinical or rehabilitation factors, or participant characteristics, that contribute to return to duty readiness?\n\nParticipants will be randomized to either complete their rehabilitation per the standard of care with a physical therapist in a Military Treatment Facility or complete the CRISP program with a research physical therapist. Participants will:\n\n* Attend physical therapy for a non-operative shoulder injury\n* Attend initial and final clinical assessments at the clinic\n* Complete patient reported outcomes at 1-, 3-, 6- and 12-month timepoints",[121,122],"Shoulder Pain","Shoulder Injuries",[124,125,126,127],"shoulder","return-to-duty","physical therapy","rehabilitation","NOT_YET_RECRUITING","2024-07-31",{"date":131,"type":33},"2024-08-02",{"date":133,"type":21},"2025-03-01",{"date":135,"type":21},"2027-08-30",{"name":39,"class":40},""]