[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad Autonoma de Baja California\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":300},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,48,76,103,127,153,173,197,219,249,278],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100635684","intervention-in-executive-functions-and-emotional-self-regulation-in-adolescents-with-primary-dysmenorrhea-100635684",false,"NCT07555886","Intervention in Executive Functions and Emotional Self-Regulation in Adolescents With Primary Dysmenorrhea","Evaluación de Una intervención psicológica Sobre Funciones Ejecutivas cálidas y autorregulación Emocional en Adolescentes Con Dismenorrea Primaria","CALMA","Inclusion criteria Gender: menstruating individuals in late adolescence.\n\n* Age: 15 to 19 years.\n* Estimated IQ above 80.\n* With painful menstrual cycles (primary dysmenorrhea) without a prior gynecological diagnosis.\n* Students at the institution selected for the intervention.\n* Written expression of willingness and interest in participating in the program (informed consent in the case of minors)\n* Informed consent signed by parents (in the case of minors) or by the participants (in the case of adults).\n* Attendance of at least 70% of the intervention sessions.\n\nExclusion criteria\n\n* Ages other than those previously indicated.\n* An estimated IQ below 80.\n* A prior gynecological diagnosis of a condition other than dysmenorrhea.\n* Pharmacological or hormonal treatment that could, in and of itself, interfere with executive functions, pain perception, and emotional regulation.\n* With psychiatric and\u002For neurological conditions that, in and of themselves, affect executive functions and emotional regulation.\n* With pain-free menstrual cycles.\n* Lack of interest or willingness to participate in the program\n* Lack of informed consent or assent.\n\nElimination criteria\n\n* Voluntary withdrawal from the program.\n* Missing more than 30% of the sessions.\n* Withdrawal of informed consent (personal, from guardians, or institutional).\n* Receiving a diagnosis that meets any of the exclusion criteria during the -intervention program.","FEMALE","15 Years","18 Years",{"count":21,"type":22},35,"ESTIMATED","INTERVENTIONAL",[25],"NA","Primary dysmenorrhea is one of the most common gynecological conditions during adolescence and is associated not only with recurrent menstrual pain, but also with emotional disturbances and difficulties in behavioral regulation. Various studies have indicated that hot executive functions-linked to emotional processing, decision-making in affective contexts, and impulse control-play a relevant role in the experience of and coping with pain.\n\nThe present project aims to design and evaluate the effectiveness of a structured psychological intervention focused on strengthening hot executive functions and emotional self-regulation in adolescents with primary dysmenorrhea. A quasi-experimental design with pre- and post-intervention assessment is proposed, using validated instruments to measure pain intensity, coping strategies, and executive-emotional performance. The intervention is expected to contribute to a reduction in perceived pain and to improvements in emotional regulation strategies, promoting more adaptive coping. This study seeks to provide empirical evidence on brief psychological interventions aimed at the comprehensive management of menstrual pain in adolescent populations.",[28],"Menstrual Cramps",[30,31,32,33,34],"Menstruation","Adolescents","Emotional regulation","Hot executive functioning","Primary dysmenorrhea.","NOT_YET_RECRUITING","2026-05-13",{"date":38,"type":39},"2026-05-18","ACTUAL",{"date":41,"type":22},"2026-08-30",{"date":43,"type":22},"2028-03-30",{"name":45,"class":46},"Universidad Autonoma de Baja California","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100637863","addressing-relational-and-communication-conflicts-in-families-with-adolescents-100637863","NCT07584421","Addressing Relational and Communication Conflicts in Families With Adolescents.","Qualitative Clinical Case Study: Addressing Relational and Communication Conflicts in Families With Adolescents in the Mexicali Valley Through a Reflective Workshop.","ARACC-FA","Inclusion Criteria:\n\n* Adolescents aged 15 to 17\n* Students enrolled in high school within the Mexicali Valley.\n* Adolescents who have difficulty identifying or expressing their emotions, such as trouble recognizing what they are feeling.\n* Adolescents who report difficulties in their relationship or communication with their parents.\n* Must have informed consent from parents or guardians and the adolescent's consent to participate in the intervention.\n* Availability to attend the intervention program sessions during the established period.\n\nExclusion Criteria:\n\n* Adolescents outside the established age range.\n* Presence of psychological disorders or diagnosed conditions requiring immediate specialized clinical care.\n* Adolescents currently undergoing intensive psychotherapy focused on similar emotional issues.\n* Lack of authorization from parents or legal guardians.\n* Repeated absences or inability to maintain continuity in the program.",true,"ALL","17 Years",{"count":60,"type":22},15,[25],"Adolescence is a stage characterized by intense emotional and social changes. Young people experience emotions more intensely, but they do not always have the necessary tools to recognize, understand, and regulate them properly. In recent decades, the mental and emotional health of adolescents has become a priority issue on the international agenda. Organizations such as the World Health Organization and the United Nations Educational, Scientific and Cultural Organization, have noted a worrying increase in emotional and psychological problems in this population, as well as a significant lack of skills to recognize and express their emotions appropriately.\n\nAn important aspect of functionality highlighted by scholars in the field is that \"a functional family is not defined by the absence of stress, conflict, or problems, but by how effectively it manages them so that they do not interfere with the well-being of its members. A dysfunctional family cannot fulfill this function\" (Colapinto in Roizblatt, 2006).\n\nAt times, parents may experience misunderstandings or problems within the home. Sharp (2022) notes that interpersonal problems were associated with higher levels of insecure attachment in adolescent offspring, such that adolescents either dismissed the need for attachment or displayed altered concern regarding the relationship; the latter focuses more on how adolescents feel regarding the relationship they have with their parents, and if they lack help or support in acknowledging everything they are going through and feeling, this can continue into adulthood and end up harming how they relate to society and their personal relationships.\n\nConsidering the context of the Mexicali Valley, characterized by social, economic, and family vulnerability, it is essential to work together on the emotional development of adolescents and the strengthening of their emotional bond with their parents. In this environment, young people not only go through the changes typical of adolescence, but they may also face complex family dynamics, limited support networks, and few opportunities for emotional education.",[64],"Relational and Communication Conflicts Between Adolescents and Their Families",[66,67,68,31,69],"Communication","Family Dynamics","Bonds","Emotions","2026-05-07",{"date":36,"type":39},{"date":41,"type":22},{"date":74,"type":22},"2028-03-15",{"name":45,"class":46},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":56,"sex":57,"minAge":19,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100635628","impact-of-play-interventions-on-stress-and-anxiety-using-eeg-and-ai-100635628","NCT07555158","Impact of Play Interventions on Stress and Anxiety Using EEG and AI.","MEASURING THE IMPACT OF PLAYFUL INTERVENTIONS IN STUDENTS WITH STRESS AND ANXIETY THROUGH THE USE OF ELECTROENCEPHALOGRAPHIC SIGNALS AND ARTIFICIAL INTELLIGENCE","ILOS-WEEG","Inclusion Criteria:\n\n* University students enrolled at the institution where the study will be conducted.\n* Ages 18 to 35.\n* Students exhibiting moderate levels of stress or anxiety related to academic assessments.\n* Students who agree to participate voluntarily and sign the informed consent form.\n* Students who are able to attend the intervention session and the neuropsychological and neurophysiological (EEG) assessments.\n* Presenting a critical stressful event (an exam)\n\nExclusion Criteria:\n\n* Students with a prior diagnosis of neurological disorders that may affect brain activity recorded by EEG.\n* Students currently undergoing psychiatric treatment or taking medications that alter brain activity.\n* Individuals with recent use of psychoactive substances that may interfere with neurophysiological recordings.\n* Students who do not complete the initial or final assessments of the study.\n* Students who refuse to sign the informed consent form.","35 Years",{"count":86,"type":22},60,[25],"This project will target university students during their exam periods, whether midterms, finals, regular exams, or make-up exams, as this is a time particularly sensitive to academic stress. Participation will be voluntary, with informed consent, and will take place in a space specially prepared to facilitate creative expression and gentle physical movement.\n\nThe intervention aims to address this need through the use of brief expressive and somatic techniques, such as guided drawing, body movement, and symbolic reinterpretation. These practices activate the parasympathetic nervous system, promoting states of calm and security that improve cognitive performance.\n\nThe intervention lasts 20 minutes in a single session, integrating spontaneous drawing, guided emotional self-reflection, and gentle body exercises. Incorporating the recording of brain activity using electroencephalography (EEG) during the intervention, in a subgroup of participants with the help of the Emotiv Epoc X device, allowing objective observation of the modulation of brain activity in response to the emotional stimulus of the exam and measuring possible changes in electrical patterns associated with states of anxiety, attention and working memory.",[90,91],"Anxiety","Stress",[91,90,93,94,95],"university students","playful activities","academic performance","2026-04-21",{"date":98,"type":39},"2026-04-29",{"date":41,"type":22},{"date":101,"type":22},"2027-03-15",{"name":45,"class":46},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":125,"leadSponsor":126,"locationsCount":47},"100633666","psychological-intervention-on-cold-executive-function-and-academic-performance-in-university-women-with-insomnia-100633666","NCT07529652","Psychological Intervention on Cold Executive Function and Academic Performance in University Women With Insomnia","Psychological Intervention in the Executive Functioning and Academic Performance of Female University Students Aged 18 to 25 Residing in the Mexicali Valley With Insomnia","LUNA MUJER","Inclusion Criteria:\n\n* Sex: Female\n* Age: 18-25\n* Chronic insomnia diagnosed by assessment tool.\n* Must be university students of any major.\n* Must have time available to participate in at least 80% of the sessions.\n* Must explicitly express their desire to participate by signing the informed consent form.\n\nExclusion Criteria:\n\n* Sex: Women in transition or men.\n* Psychiatric or neurological diagnosis other than insomnia.\n* Use of psychoactive substances.\n* Under pharmacological treatment for any medical, psychiatric, or neurological condition, including insomnia.\n\nElimination Criteria:\n\n* Voluntary withdrawal\n* Absence from more than 20% of sessions.\n* Receiving a diagnosis and\u002For treatment that interferes with the variables evaluated and addressed.","25 Years",{"count":21,"type":22},[25],"Sleep disturbances, particularly insomnia, are highly prevalent among university women and are associated with impairments in executive functioning and academic performance. Women present higher rates of insomnia due to biological and psychosocial factors. This study aims to design and evaluate a psychological intervention program to improve sleep quality and reduce insomnia symptoms in female university students aged 18-25, with the purpose of strengthening cold executive functions and analyzing its impact on academic performance.",[116],"Insomnia",[116,118,119,120],"Cold-Executive-Functions","Academic-Performance","Woman","2026-04-10",{"date":123,"type":39},"2026-04-14",{"date":41,"type":22},{"date":74,"type":22},{"name":45,"class":46},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":56,"sex":17,"minAge":135,"maxAge":19,"enrollmentInfo":136,"targetDuration":4,"studyType":23,"phases":138,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":151,"leadSponsor":152,"locationsCount":4},"100630777","executive-functions-and-emotional-intelligence-in-pregnant-adolescents-100630777","NCT07492082","Executive Functions and Emotional Intelligence in Pregnant Adolescents","Emotional Intelligence and Executive Functions in Pregnant Adolescents Living in Rural Areas: a Study of a Psychological Intervention","EFAEIPA","Inclusion Criteria:\n\n* Be in the first or second trimester of pregnancy at the time of the procedure.\n* Be between the ages of 14 and 18.\n* Have a basic level of literacy (be able to read and write).\n* Receive prenatal medical care.\n* Sign the informed consent form, both the patient and an adult family member.\n\nExclusion Criteria:\n\n* Serious medical conditions that limit your participation and\u002For continued participation in the study.\n* Neurological or psychiatric conditions (other than mild to moderate depression and anxiety) that have an impact on executive functioning and emotional intelligence on their own.\n* No interest or availability to participate in the entire program.","14 Years",{"count":137,"type":22},30,[25],"Teenage pregnancy is a major global public health issue and is associated with a range of psychosocial, emotional, and developmental challenges. Adolescence is a critical stage of development characterized by the ongoing maturation of executive functions, including inhibitory control, emotional regulation, working memory, planning, and decision-making. These cognitive and emotional processes are essential for adaptive functioning and psychological well-being. However, when pregnancy occurs during adolescence, young women may face additional stressors, such as social stigma, limited social support, disruption of education, and economic vulnerability, which can negatively affect their mental health and coping abilities.\n\nPrevious research has shown that pregnant adolescents may experience higher levels of emotional distress, anxiety, and depressive symptoms compared to pregnant adult women. Furthermore, difficulties in executive functions and emotional regulation may influence adolescents' ability to manage stress, regulate their emotions, and make adaptive decisions during pregnancy and the transition to motherhood. Therefore, interventions that strengthen emotional and cognitive self-regulation may play an important role in improving the psychological adjustment and well-being of pregnant adolescents.\n\nThe present study aims to evaluate the effectiveness of an intervention designed to improve emotional intelligence and executive functions in pregnant adolescents. The program seeks to promote greater emotional understanding and self-regulation, as well as to support adolescents in coping with the psychological challenges associated with pregnancy.\n\nParticipants will complete standardized psychological assessments before and after the intervention to evaluate potential changes in executive functioning and emotional well-being.\n\nBy assessing the impact of an intervention on emotional intelligence and executive functions, this study seeks to contribute to the development of evidence-based strategies to improve the mental health and psychosocial outcomes of pregnant adolescents. The results may provide valuable information for healthcare professionals, psychologists, and public health programs seeking to support adolescent mothers and promote healthier developmental trajectories during pregnancy and early motherhood.",[141],"Teenage Pregnancy",[143,144,145,146],"Execute functions","Inhibitory control","Planning","Emotional intelligence","2026-03-27",{"date":149,"type":39},"2026-04-02",{"date":41,"type":22},{"date":74,"type":22},{"name":45,"class":46},{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":56,"sex":57,"minAge":19,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":23,"phases":163,"briefSummary":164,"conditions":165,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":171,"leadSponsor":172,"locationsCount":4},"100630775","brain-function-messures-of-a-psychological-flexibility-skills-training-based-on-act-over-disordered-eating-behaviors-100630775","NCT07492056","Brain Function Messures of a Psychological Flexibility Skills Training Based on ACT Over Disordered Eating Behaviors","Electroencephalographic and Body Composition and Psychometric Mesures of a Training of Psychological Flexibility Skills Based on ACT on ACT Processes on University Students of Mexicali and Mexicali Valley.","FLEXEAT","Inclusion Criteria:\n\n* Between 18 and 30 years old.\n* Currently enrrolled in university studies.\n* Attend at least 80% of the intervention sessions.\n\nExclusion Criteria:\n\n* Having a diagnosis of personality disorder.\n* Failure to attend post-assessment.\n* Currently attending psychological therapy or psychiatric care..","30 Years",{"count":137,"type":22},[25],"Overweight and obesity are an increasing tendencies worldwide. Disordered Eating Behaviors (DEBs) are feeding dynamics commonly present on them, as in Feeding Disorders (FD). These eating and body conditions are highly correlated with specific psychopathological symtoms, such as anxiety and depression, weight-related shame and stigma, and academic stress. Additionally, electroencephalographic findings suggest that weight- and eating-related conditions may be mediated by neural pathways specific to executive functions, such as selective attention and inhibitory control. Therefore, this cuasi-experimental design, pre- and post- measurement, longitudinal cross-sectional study aims to evaluate the effect of a training on psychological flexibility skills, based on Acceptance and Commitment Therapy (ACT) processes, on psychological, electroencephalographic and body composition measures.",[166],"General Population (no Specific Condition or Disease)","2026-03-26",{"date":169,"type":39},"2026-04-01",{"date":41,"type":22},{"date":101,"type":22},{"name":45,"class":46},{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":56,"sex":57,"minAge":181,"maxAge":58,"enrollmentInfo":182,"targetDuration":4,"studyType":23,"phases":184,"briefSummary":185,"conditions":186,"keywords":188,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":195,"leadSponsor":196,"locationsCount":47},"100630776","life-skills-based-intervention-on-substance-use-intention-in-adolescents-in-social-care-institutions-100630776","NCT07492069","Life Skills-Based Intervention on Substance Use Intention in Adolescents in Social Care Institutions","Inhibitory Control, Emotional Regulation, and Peer Pressure: Neurophysiological and Psychological Effects of a Life Skills Intervention to Reduce Substance Use Intention in Institutionalized Children a Randomized Clinical Trial.","CASA-HpV","Inclusion Criteria:\n\n* Adolescents aged 12 to 17 who have lived in the participating children's home.\n* Ability to understand and respond to the tests and questionnaires administered during the study.\n* Approval and signature of the director or legal guardians of the social welfare institutions on the informed consent form.\n\nInformed consent of the adolescent.\n\nExclusion Criteria:\n\n* Adolescents diagnosed with externalizing disorders, intellectual disabilities, or severe or serious psychiatric disorders that prevent them from understanding the intervention protocol.\n* Adolescents who are undergoing administrative processes such as family reintegration or imminent relocation that make it difficult to complete the assessments.\n* Participation in other studies that interfere with the application of the assessment instruments.\n* Situations of acute emotional, medical, or behavioral crisis observed by the administrative staff of social welfare institutions.","12 Years",{"count":183,"type":22},20,[25],"Objective: evaluate the impact of a Life Skills Training (LST) intervention on substance use intention by analyzing changes in neuropsychological organization and psychological regulation processes in adolescents living in social assistance institutions.Methodology Design: Parallel-group randomized controlled trial with a 1:1 allocation ratio. Participants: 20 adolescents aged 12 to 17 with a minimum of 3 months of residence in foster care homes in Mexicali, Baja California.Intervention: The experimental group will undergo 8 sessions (60 minutes each) of LST, while the control group will receive a traditional psychoeducational intervention of the same duration.Key Measures: Electroencephalography (EEG) will be used to monitor cortical maturation (Alpha\u002FTheta power) and frontal asymmetry. Clinical scales including DERS, DUSI, BANFE-2, and substance use intention questionnaires will also be administered.RationaleIn Mexico, the average age of onset for substance use has dropped to 12-13 years. Institutionalized adolescents face heightened vulnerability due to histories of trauma, neglect, and environmental exposure to high-lethality substances such as fentanyl and methamphetamines in the border region",[187],"Institutionalization",[189,187,190],"Children,","Life Skills Training","2026-03-25",{"date":193,"type":39},"2026-03-31",{"date":41,"type":22},{"date":101,"type":22},{"name":45,"class":46},{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":57,"minAge":19,"maxAge":111,"enrollmentInfo":204,"targetDuration":206,"studyType":207,"phases":4,"briefSummary":208,"conditions":209,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":4},"100607101","validation-of-heart-rate-monitors-in-overweight-and-obese-young-adults-100607101","NCT07184177","Validation of Heart Rate Monitors in Overweight and Obese Young Adults","Validation of the Accuracy of Heart Rate Monitors at Resting and Exercise at Maximal Fat Oxidation Rate in Overweight and Obese Young Adults","Inclusion Criteria:\n\n* Body mass index ≥ 25 kg\u002Fm2\n* Energy expenditure \\\u003C 600 METs a week\n* Acceptance of informed consent\n\nExclusion Criteria:\n\n* ≥100 mL of alcohol consumption per week\n* Have limitations to perform regular physical activity\n* Have a chronic non-communicable disease\n* Answer \"yes\" to any of the questions on the Physical Activity Readiness-Questionnaire for Everyone (PAR-Q+), which represents a health risk.",{"count":205,"type":22},52,"1 Day","OBSERVATIONAL","Overweight and obesity are defined as an excessive accumulation of body fat that affects health. According to data from the World Health Organization (WHO), in 2022, there were 2.5 billion adults aged 18 years and older who were overweight, of whom 890 million were obese. In other words, 43% of adults aged 18 years and older were overweight, and 16% of them were obese.\n\nOverweight and obesity are key risk factors for various chronic diseases such as diabetes, hypertension, cardiovascular disease, and even some types of cancer. There is evidence that mortality from cardiovascular disease, and the incidence of cancer and diabetes, varies according to the amount of physical activity. In the context of high levels of sedentary time, higher levels of moderate to vigorous physical activity are recommended. There are various ways to treat overweight and obesity, the main ones usually being lifestyle changes, such as following a healthy diet and regular physical activity, as well as following pharmacological treatments. In this project, the focus will be on the fat metabolism generated during moderate physical activity.\n\nThere are physical activity interventions aimed at increasing fat metabolism that may potentially reduce the symptoms of metabolic diseases such as obesity and type 2 diabetes. For this purpose, it is important to understand the factors that increase or decrease fat oxidation. Factors such as exercise intensity and duration are important to understand when determining maximum fat oxidation (FatMax).\n\nThe aim is to develop comprehensive research that will generate knowledge and evidence on health issues with social impact through the evaluation of commercial technologies and innovative actions that promote the prevention, treatment, and resolution of national health problems such as obesity.",[210],"Obesity &Amp; Overweight","2025-09-18",{"date":213,"type":39},"2025-09-19",{"date":215,"type":22},"2026-01-19",{"date":217,"type":22},"2026-12-04",{"name":45,"class":46},{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":57,"minAge":226,"maxAge":227,"enrollmentInfo":228,"targetDuration":4,"studyType":23,"phases":230,"briefSummary":231,"conditions":232,"keywords":236,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":47},"100599964","3d-printed-ceromer-crowns-versus-stainless-steel-in-posterior-primary-molars-100599964","NCT07091331","3D-printed Ceromer Crowns Versus Stainless Steel in Posterior Primary Molars","Clinical Evaluation of 3D-printed Ceromer Crowns Versus Stainless Steel in Posterior Primary Molars","Inclusion Criteria:\n\n* Children aged 4 to 9 years with at least 2 primary molars affected by deep occlusoproximal caries.\n* Teeth may require pulp therapy (pulpotomy or pulpectomy) and be suitable for full-coverage restoration.\n* Teeth must have an antagonist and be located in opposing hemiarches.\n* The affected primary molars must be expected to remain in the mouth for at least 12 months.\n* The child must be in general good health.\n* Parents or legal guardians must sign informed consent, and the child must provide assent.\n* Patient does not come to control appointment or does not want to continue research.\n\nExclusion Criteria:\n\n* Children with systemic diseases or medical conditions affecting oral health.\n* Uncooperative behavior (Frankl scale 3 or 4).\n* Temporomandibular joint disorders or parafunctional habits (e.g., bruxism).\n* Absence of antagonist or adjacent teeth in the selected quadrants.\n* Children on long-term medication.\n* Patient with allergy to local anesthetic, nickel or chromium.","4 Years","9 Years",{"count":229,"type":22},40,[25],"The aim of the study is to compare preformed metal crowns and 3D-printed ceromer crowns in primary molars of 4-9 years old children. The main questions it aims to answer are:\n\n* How does 3D-printed ceromer crowns compare clincally to stainless steel crowns when restoring posterior molars?\n* What is the level of satisfaction of the patient with both materials?\n* What is the level of parental satisfaction with both materials?\n\nStudy methodology:\n\nThis study is a split-mouth clinical trial where participants will receive at least one of each materials in different quadrants of the mouth.",[233,234,235],"Caries, Dental","Caries; Dentin","Dental Caries in Children",[237,238,239,240],"Printing, Three-dimensional","Pediatric Dentistry","Tooth, Deciduous","Esthetics, Dental","2025-07-22",{"date":243,"type":39},"2025-07-29",{"date":245,"type":22},"2025-07-30",{"date":247,"type":22},"2026-06-15",{"name":45,"class":46},{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":255,"eligibilityCriteria":256,"healthyVolunteers":56,"sex":57,"minAge":19,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":207,"phases":4,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":269,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":47},"100582912","insomnias-impact-on-dna-stability-cardio-metabolic-health-and-lifestyle-behaviors-100582912","NCT06869486","Insomnia´s Impact on DNA Stability, Cardio-metabolic Health and Lifestyle Behaviors","Insomnia´s Impact on DNA Stability, Cardio-metabolic Health and Lifestyle Behaviors: A Case-control Study","INSIGHTS","Inclusion Criteria:\n\nEach population group will meet the following inclusion criteria:\n\n* Healthy Individuals (18-35 years old, men and women)\n\n  * Waist circumference: \\\u003C90 cm (men), \\\u003C80 cm (women)\n  * Fasting glucose: 70-110 mg\u002FdL\n  * Blood pressure: \\\u003C120\u002F80 mmHg\n  * Triglycerides: \\\u003C150 mg\u002FdL\n  * HDL-C: \\>40 mg\u002FdL (men), \\>50 mg\u002FdL (women)\n  * Physical activity level: 600-1500 MET-min\u002Fweek\n* Athletes (18-35 years old, men and women)\n\n  \\*Engaged in structured sports training with a physical activity level \\>1500 MET-min\u002Fweek\n* Older Adults (65-75 years old, men and women)\n\n  \\*Free of cognitive or mental health disorders. No specific cardiometabolic or body composition criteria due to the study's exploratory nature.\n* University Students (18-35 years old, men and women)\n\n  \\*No specific cardiometabolic or body composition criteria due to the study's exploratory nature.\n* Individuals with Metabolic Syndrome (18-35 years old, men and women)\n\n  * Waist circumference: \\>90 cm (men), \\>80 cm (women)\n  * Fasting glucose: \\>110 mg\u002FdL\n  * Blood pressure: \\>130\u002F80 mmHg\n  * Triglycerides: \\>150 mg\u002FdL\n  * HDL-C: \\\u003C40 mg\u002FdL (men), \\\u003C50 mg\u002FdL (women)\n  * Physical activity level: \\\u003C600 MET-min\u002Fweek\n\nExclusion Criteria:\n\n* Individuals with respiratory diseases or musculoskeletal injuries that prevent exercise, as determined by a clinical history review, a physical activity readiness questionnaire (PART-Q+), and pulmonary function tests (spirometry).\n\nIndividuals with rotating or night-shift work schedules (e.g., emergency personnel, security guards), as circadian rhythm disruptions significantly impact sleep quality\n\n* Women diagnosed with polycystic ovary syndrome (PCOS) or showing high testosterone levels with a history of oligomenorrhea, as these conditions may influence metabolic and hormonal markers. However, women with menstrual irregularities related to premenstrual syndrome (PMS) or dysmenorrhea will not be excluded, given the established link between sleep disorders and menstrual cycle variations\n* This study does not involve chronic dietary or exercise interventions, nor does it require long-term participant follow-up, so no additional exclusion criteria apply","75 Years",{"count":259,"type":22},300,"Insomnia is a highly prevalent sleep disorder worldwide, with an increasing incidence in athletes, older adults, university students, and individuals with metabolic syndrome. This disorder has been associated with metabolic dysfunction, cardiovascular diseases, and genetic instability. Recent evidence suggests that insomnia negatively impacts cardiorespiratory fitness, insulin sensitivity, and overall health through mechanisms involving neuroendocrine dysregulation, oxidative stress, and alterations in energy metabolism. However, the specific biological and environmental factors that contribute to its prevalence and health consequences remain poorly understood, particularly across different populations. Understanding these associations is crucial for developing effective prevention and intervention strategies to mitigate the long-term impact of insomnia. Therefore, this study aims to analyze the impact of insomnia on body composition, cardiorespiratory fitness, metabolic flexibility, and DNA integrity, across populations with high prevalence of insomnia, including athletes, older adults, university students, and individuals with metabolic syndrome. This study will also investigate which biological and lifestyle behaviors contribute to insomnia and its health consequences. By doing so, this work will provide critical insights into the physiological and molecular mechanisms that link insomnia with metabolic and cardiovascular dysfunction, contributing to the development of targeted interventions for at-risk populations",[116,262,263],"Cardiorespiratory Fitness","Metabolic Disease",[265,266,267,268],"Physical Activity","Physical Fitness","DNA integrity","Endocrinology and Metabolism","RECRUITING","2025-03-04",{"date":272,"type":39},"2025-03-11",{"date":274,"type":39},"2024-10-01",{"date":276,"type":22},"2026-12-31",{"name":45,"class":46},{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":56,"sex":57,"minAge":19,"maxAge":84,"enrollmentInfo":285,"targetDuration":4,"studyType":23,"phases":287,"briefSummary":288,"conditions":289,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":47},"100558620","fatmax-training-on-metabolic-and-epigenetic-parameters-100558620","NCT06553482","FatMax Training on Metabolic and Epigenetic Parameters","Impact of Exercise Training at Maximal Fat Oxidation (FatMax) Intensity on Metabolic and Epigenetic Parameters in Subjects With Excessive Body Mass: Study Protocol of a Randomized Controlled Trial","Inclusion Criteria:\n\n* Both genders\n* Daily energy expenditure \\\u003C4 METs\n* Body mass index ≥25 kg\u002Fm2\n* Acceptance of informed consent\n\nExclusion\u002Felimination Criteria:\n\n* ≥100 ml of alcohol consumption per week\n* Consume a dietary supplement or pharmacological treatment\n* Have limitations to perform regular physical activity\n* Have a chronic non-communicable disease\n* Answer \"yes\" to any of the questions on the Physical Activity Readiness- Questionnaire for Everyone (PAR-Q+); which represents a health risk.\n* \\\u003C80% attendance at exercise sessions",{"count":286,"type":22},156,[25],"Exercise is an essential pillar for the health of all individuals, as it contributes to physical, mental, and emotional well-being. Various international organizations, such as the World Health Organization, advocate for the integration of exercise into healthy lifestyles, recognizing its im-portance in disease prevention and improving quality of life. However, despite the general consensus on its value, there is no universal agreement on specific prescriptions for vulnerable groups, highlighting the need for personalized approaches that consider the unique characteristics and needs of each individual. It has been proposed that a moderate aerobic exercise training program could promote positive outcomes in individuals living with overweight and obesity, particularly with an emphasis on reducing injury risk, ensuring high adherence, and achieving favorable health changes. In this regard, the present protocol establishes the basis for a randomized clinical trial based on exercise prescription at the maximal fat oxidation rate in young individuals with overweight and obesity, with a duration of 16 weeks. Throughout the study, biochemical changes (cholesterol, glucose, triglycerides, and inflammatory markers), metabolic changes (de-termination of fat and carbohydrate utilization rates during rest and exercise), and epigenetic changes (focusing on microRNAs associated with adipogenesis, inflammation, and fat metabolism) will be monitored.",[290,291],"Overweight and Obesity","Body Weight Changes","2024-08-13",{"date":294,"type":39},"2024-08-15",{"date":296,"type":22},"2025-01-01",{"date":298,"type":22},"2027-01-01",{"name":45,"class":46},""]