[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad Francisco de Vitoria\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":317},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,51,83,113,141,170,198,219,243,269,293],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100637766","effects-of-moderate-intensity-interval-aerobic-exercise-miiae-on-inflammatory-immune-metabolic-physical-fitness-and-quality-of-life-parameters-in-breast-cancer-patients-undergoing-radiotherapy-100637766",false,"NCT07583719","Effects of Moderate-intensity Interval Aerobic Exercise (MIIAE) on Inflammatory, Immune, Metabolic, Physical Fitness, and Quality of Life Parameters in Breast Cancer Patients Undergoing Radiotherapy.","Inclusion Criteria:\n\n* Women aged between 20 and 65 years.\n* Clinical diagnosis of breast cancer (Stage I-III).\n* Patients who have undergone lumpectomy or mastectomy.\n* Scheduled to start radiotherapy treatment.\n* Sedentary lifestyle according to international physical activity guidelines.\n* Ability to understand and follow instructions.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Presence of infectious disease.\n* Cardiovascular or respiratory disease.\n* Metastatic disease.\n* Uncontrolled diabetes mellitus.\n* Neuropathy.\n* Physically active individuals meeting WHO physical activity recommendations.\n* Participation in an exercise intervention program within the last 3 months.\n* Any condition that, in the opinion of the research team, may compromise safety or participation.","FEMALE","20 Years","65 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Breast cancer and its treatment with radiotherapy may be associated with systemic inflammatory, hematological, cardiac, body composition, functional and quality-of-life alterations. Exercise has emerged as a non-pharmacological strategy with potential benefits during oncological treatment; however, further evidence is needed regarding the effects of supervised moderate-intensity interval aerobic exercise during radiotherapy.\n\nThis randomized controlled trial aims to evaluate the effects of a supervised moderate-intensity interval aerobic exercise programme on systemic inflammatory and immune-derived hematological indices, cardiac biomarkers, body composition, muscle strength, lower-limb power, sleep quality and breast cancer-specific quality of life in women with breast cancer undergoing radiotherapy.\n\nParticipants will be allocated to either an experimental group performing supervised moderate-intensity interval aerobic exercise during radiotherapy or to a control group receiving usual care without structured exercise during the study period. Outcomes will be assessed at baseline and after completion of the intervention period.",[26,27,28,29,30],"Radiotherapy","Inflamation","Immune System","Physical Fitness","Breast Cancer",[32,33,34,35,36,30,37,38],"Interval Training","Inflammation","Body Composition","Quality of Life","Immune function","Sleep","oncology rehabilitation","NOT_YET_RECRUITING","2026-05-06",{"date":42,"type":43},"2026-05-13","ACTUAL",{"date":45,"type":20},"2026-06-01",{"date":47,"type":20},"2026-12-31",{"name":49,"class":50},"Universidad Francisco de Vitoria","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":63,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":4},"100635727","longitudinal-assessment-of-lung-function-and-respiratory-muscle-strength-following-training-of-the-inspiratory-muscles-in-frail-older-adults-imt-3-100635727","NCT07556445","Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3)","Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults: A Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Adults aged 80 years or older.\n* Clinical diagnosis of frailty, defined by a Short Physical Performance\n* Battery (SPPB) score \\\u003C 9.\n* Ability to stand and walk with or without assistive devices.\n* Ability to understand and follow instructions for inspiratory muscle training.\n* Stable medical condition for at least 3 months prior to enrollment.\n* Capacity to provide informed consent or availability of a legal\n\nExclusion Criteria:\n\n* Severe cognitive impairment that prevents understanding the procedures.\n* Diagnosis of neuromuscular diseases affecting respiratory muscles (e.g., ALS, myopathies).\n* Severe or uncontrolled hypertension (≥180\u002F110 mmHg).\n* Recent thoracic or abdominal surgery (\\\u003C3 months).\n* Severe musculoskeletal disorders limiting participation in training.\n* History of recurrent syncope, severe dizziness, or intolerance to respiratory maneuvers.\n* Any condition judged by the research team to compromise safety or participation.",true,"ALL","80 Years",{"count":62,"type":20},30,[23],"This study aims to evaluate the effects of an 8-week inspiratory muscle training program on lung function and respiratory muscle strength in frail older adults aged 80 years and above. Frailty is associated with reduced physical capacity, declines in functional performance, impaired respiratory performance, and a higher risk of disability. Inspiratory muscle training is a simple, low-cost intervention that may improve breathing function, inspiratory muscle strength, and overall health in very old adults, but evidence in this age group remains limited. Participants will be randomly assigned to one of two groups: a high-load inspiratory muscle training group or a low-load sham training group. Both groups will use a threshold device and perform 30 breaths once per day, five days per week, for eight weeks. The experimental group will train with progressively increasing resistance (50% to 80% of maximal inspiratory pressure), while the sham group will use a minimal and non-progressive load (15% of maximal inspiratory pressure). All sessions will be supervised and monitored for safety. The main goal of the study is to determine whether inspiratory muscle training improves maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP) and lung function. These outcomes will allow the evaluation of the clinical relevance of improvements in respiratory muscle strength in this population.\n\nAssessments will be performed before the intervention, immediately after the 8-week program, and again at one and three months after the end of the intervention to examine both immediate and short-term effects. This study may contribute valuable evidence regarding the safety, feasibility, and clinical benefits of inspiratory muscle training in frail very old adults, particularly its impact on respiratory muscle strength and lung function, supporting its potential implementation in rehabilitation and geriatric care.",[66,67,68,69],"Frailty Syndrome","Geriatric Health","Respiratory Muscle Weakness","Age-Related Frailty",[71,72,73,74],"Inspiratory Muscle Training","Older Adults","Lung Function","Respiratory Muscle Strength","2026-04-29",{"date":77,"type":43},"2026-04-30",{"date":79,"type":20},"2026-05-20",{"date":81,"type":20},"2026-12-01",{"name":49,"class":50},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":59,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":21,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":4},"100623766","effectiveness-of-a-standardised-stabilisation-exercise-protocol-in-volleyball-players-with-non-traumatic-shoulder-instability-100623766","NCT07400900","Effectiveness of a Standardised Stabilisation Exercise Protocol in Volleyball Players With Non-traumatic Shoulder Instability","Inclusion criteria:\n\n* Amateur volleyball players.\n* Age range: 18 to 30 years.\n* Clinical diagnosis of atraumatic shoulder instability.\n* Symptom duration greater than 3 months.\n\nExclusion criteria:\n\n* Previous surgeries on the affected shoulder.\n* Previous fractures of the affected shoulder.\n* History of traumatic shoulder dislocation.\n* Shoulder pain originating from cervical spine pathology.\n* Presence of pain in the elbow, wrist, or hand.\n* Clinical diagnosis of rotator cuff-related shoulder pain or frozen shoulder.\n* Medical diagnosis of cardiovascular, rheumatologic, or neurological disorders.\n* Pregnancy.\n* Cognitive impairment.\n* Concurrent physiotherapy treatment during the study period.\n* Use of analgesic or anti-inflammatory medication within 24 hours prior to study assessments.","18 Years","30 Years",{"count":92,"type":20},22,[23],"This randomized controlled clinical trial aims to evaluate the effectiveness of a standardized shoulder stabilization exercise program in amateur volleyball players diagnosed with atraumatic shoulder instability. Shoulder pain is one of the most prevalent musculoskeletal complaints, affecting up to two-thirds of the general population at some point in life and frequently leading to long-term symptoms, functional limitations, sleep disturbances, and high socio-economic costs. Atraumatic glenohumeral instability is particularly common among athletes performing overhead movements, such as volleyball players, who are repeatedly exposed to high-velocity external and internal rotation actions during serves and spikes.\n\nThe Derby Shoulder Instability Rehabilitation Programme (DSIRP) is a structured, reproducible protocol integrating strengthening, proprioceptive, neuromuscular control, plyometric, and speed-oriented exercises. Although widely used in clinical practice, evidence supporting its superiority over the natural progression of the condition remains limited. More than 80% of physiotherapists in the United Kingdom do not use specific standardized protocols for atraumatic shoulder instability, highlighting the need for high-quality clinical trials that evaluate structured rehabilitation approaches.\n\nThis study will recruit amateur volleyball players aged 20 to 30 years with a clinical diagnosis of atraumatic shoulder instability lasting more than 3 months. Participants will be randomized (1:1) into two parallel groups: an experimental group performing the DSIRP for 8 weeks (three 25-minute sessions per week), and a control group following a \"wait-and-see\" approach. Outcome measures will be assessed at baseline, 1 month, and 2 months (post-intervention). The primary outcomes include pain intensity measured with the Numeric Pain Rating Scale and shoulder disability measured with the Spanish version of the Shoulder Pain and Disability Index. Secondary outcomes include external rotation strength, grip strength, shoulder range of motion, and health-related quality of life assessed with the SF-12 questionnaire. All measurements use validated instruments with high reliability for clinical and research settings.\n\nStatistical analysis will follow an intention-to-treat approach using mixed-model repeated-measures ANOVA or non-parametric alternatives when appropriate. Effect sizes and Bonferroni correction for multiple comparisons will be applied. An independent biostatistician blinded to allocation will conduct the analysis. The study follows CONSORT and TIDieR guidelines for reporting and intervention description.\n\nThis trial seeks to determine whether a structured, progressive stabilization protocol offers clinically meaningful improvements in pain, disability, strength, mobility, and quality of life compared with no intervention in young volleyball players with atraumatic shoulder instability. Results may support the implementation of standardized rehabilitation strategies in physiotherapy practice for this condition.",[96],"Shoulder Instability",[98,99,100,101,102,103,104],"voleyball","shoulder pain","instability","exercise","Derby Shoulder Instability Rehabilitation Programme","randomized controlled trial","overhead","2026-04-28",{"date":107,"type":43},"2026-05-04",{"date":109,"type":20},"2026-05-01",{"date":111,"type":20},"2026-08-01",{"name":49,"class":50},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":58,"sex":15,"minAge":89,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":21,"phases":124,"briefSummary":125,"conditions":126,"keywords":129,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":4},"100631873","sdt-based-intervention-for-exercise-motivation-in-female-students-100631873","NCT07506343","SDT-Based Intervention for Exercise Motivation in Female Students","Study Protocol for a Randomized Controlled Trial of a Self-determination Theory-Based Psychoeducational Intervention to Enhance Autonomous Motivation for Exercise in Female University Students","No acronym use","Inclusion Criteria:\n\n* Female sex\n* Age between 18 and 25 years\n* Enrolled in Health Sciences programs (Physical Activity and Sport Sciences, Physiotherapy, Human Nutrition and Dietetics, Nursing) at Universidad Francisco de Vitoria\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Current or previous diagnosis of an eating disorder\n* Failure to complete baseline or post-intervention questionnaires\n* Identification of an eating disorder after enrollment, which triggers referral according to the well-being protocol","25 Years",{"count":123,"type":20},194,[23],"Physical inactivity, maladaptive exercise motives, and body image concerns are highly prevalent among young adult women and are associated with reduced psychological well-being and increased risk for disordered eating. This study protocol describes a randomized controlled trial designed to evaluate a multi-component psychoeducational intervention integrating Self-Determination Theory principles with functionality-oriented body image strategies to enhance autonomous motivation for exercise and promote psychological well-being among female university students. Female Health Sciences students aged 18-25 will be randomly allocated (1:1) to an experimental or control group following baseline assessment, and outcomes will be evaluated at baseline, post-intervention, and six-week follow-up. The six-session face-to-face intervention incorporates autonomy-supportive communication, competence-building activities, meaningful rationales, choice provision, and supportive relational climates, combined with functionality-based body image content. The primary outcome is autonomous motivation for exercise (BREQ-3; Relative Autonomy Index), and secondary outcomes include basic psychological need satisfaction and frustration, physical activity levels, positive body image, and eating disorder risk. Linear mixed-effects models will be used under an intention-to-treat approach, and mediation analyses will test whether changes in psychological need satisfaction underlie improvements in motivational quality. The intervention is expected to promote healthier motivational regulation, increase physical activity engagement, strengthen positive body image, and reduce maladaptive exercise drivers. Findings aim to inform scalable, theory-driven preventive strategies for improving health and well-being among young women in university settings.",[127,128],"Body Image","Physical Activity",[130,131,132],"SDT theory","Gender gap","ED risk","2026-03-27",{"date":135,"type":43},"2026-04-01",{"date":137,"type":20},"2026-10-01",{"date":139,"type":20},"2027-04-30",{"name":49,"class":50},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":59,"minAge":149,"maxAge":89,"enrollmentInfo":150,"targetDuration":4,"studyType":21,"phases":152,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":160,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":169},"100630226","virtual-reality-intervention-vr-ginso-for-reducing-aggression-in-young-offenders-100630226","NCT07484919","Virtual Reality Intervention (VR-GINSO) for Reducing Aggression in Young Offenders","Virtual Reality Intervention (VR--GINSO) for Reducing Aggression in Young Offenders","VR-GINSO","Inclusion Criteria:\n\n* 12-18 years old at the moment of recruitment and allocation.\n* Minimum facility stay of 6 months since the begining of the study.\n* Documented records of recent aggresive behavior.\n\nExclusion Criteria:\n\n* Neurological disorder, brain injury, or psyquiatric pathology that affects cognitive functions or advises against use of virtual reality.\n* Not being fluent in Spanish.","12 Years",{"count":151,"type":20},110,[23],"The goal of this clinical trial is to see if a specific intervention program that uses virtual reality (VR) helps young people reduce aggressive behavior more than the same program without VR or their usual treatment. The study will also look at how the program affects anger, impulsivity, emotional control, and how participants understand and handle conflicts with others.\n\nThe main questions the study wants to answer are:\n\n* Does the intervention program with VR help young people reduce aggressive behavior more than the same program without VR or just their usual treatment?\n* What changes in the mind and body are linked to improvements in aggressive behavior and emotional control?\n\nThe researchers will compare three groups of young people:\n\n* Usual treatment plus the 4-session intervention program with VR.\n* Usual treatment plus the 4-session intervention program without VR.\n* Usual treatment only.\n\nParticipants will:\n\n* Attend 4 individual sessions lasting 1 to 1.5 hours, once a week.\n* Take part in activities to learn how to recognize emotions, understand conflict situations, and manage anger and impulsivity.\n* Complete questionnaires about aggressive behavior, anger, impulsivity, emotional control, and how they interpret conflicts.\n* Have their aggressive behavior recorded through disciplinary reports at the center.\n* Provide saliva samples before and after sessions to measure hormones related to stress and aggression.\n* Wear a chest band that measures heart rate and a headset that records brain activity during the VR activities.\n\nAll data will be kept confidential, and the identities of participants will be protected at all times.",[155],"Aggression",[157,158,159],"youth violence","virtual reality","juvenile offenders","RECRUITING","2026-03-17",{"date":163,"type":43},"2026-03-20",{"date":165,"type":43},"2025-12-15",{"date":167,"type":20},"2026-10",{"name":49,"class":50},1,{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":59,"minAge":89,"maxAge":90,"enrollmentInfo":177,"targetDuration":4,"studyType":21,"phases":179,"briefSummary":180,"conditions":181,"keywords":183,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":195,"leadSponsor":197,"locationsCount":4},"100627715","effects-of-transcutaneous-neuromodulation-and-cervical-exercise-in-students-with-chronic-nonspecific-cervical-pain-100627715","NCT07452237","Effects of Transcutaneous Neuromodulation and Cervical Exercise in Students With Chronic Nonspecific Cervical Pain","TN-E-CNCP","Inclusion Criteria:\n\n* University students aged 18-30 years\n* Chronic non-specific neck pain lasting ≥ 3 months\n* Pain intensity \\>3\u002F10 on VAS\n* No pharmacological or physiotherapy treatment in the past 3 months\n\nExclusion Criteria:\n\n* Specific cervical pathology (e.g., radiculopathy)\n* Neurological, cardiovascular, systemic, or infectious disease\n* Diagnosed psychological disorders\n* Pregnancy or postpartum period \\\u003C 1 year\n* Regular use of analgesics, opioids, or antidepressants\n* Previous cervical spine or shoulder surgery\n* Electronic implants\n* Neck pain associated with vertigo",{"count":178,"type":20},51,[23],"This randomized controlled trial aims to compare the effectiveness of a cervical exercise program, transcutaneous neuromodulation of the spinal accessory nerve, and a placebo intervention on pain intensity, pressure pain threshold, cervical proprioception, functional disability, depression, anxiety, and stress in university students with chronic non-specific neck pain. The study will include a six-week intervention period with pre- and post-treatment assessments. The findings may contribute to the development of accessible physiotherapy interventions within university settings.",[182],"Chronic Non-specific Neck Pain",[184,185,186,187,188,189,190],"Chronic Non-Specific Neck Pain","Neck Pain","University Students","Cervical Exercise","Deep Cervical Flexor Training","Transcutaneous Neuromodulation","Low-Frquency Electrical Stimulation","2026-03-05",{"date":193,"type":43},"2026-03-09",{"date":135,"type":20},{"date":196,"type":20},"2026-07-01",{"name":49,"class":50},{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":59,"minAge":60,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":21,"phases":206,"briefSummary":207,"conditions":208,"keywords":209,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":4},"100618185","longitudinal-assessment-of-maximal-inspiratory-pressure-and-functional-capacity-following-inspiratory-muscle-training-in-frail-older-adults-imt-2-100618185","NCT07328334","Longitudinal Assessment of Maximal Inspiratory Pressure and Functional Capacity Following Inspiratory Muscle Training in Frail Older Adults (IMT-2)","Longitudinal Assessment of Maximal Inspiratory Pressure and Functional Capacity Following Inspiratory Muscle Training in Frail Older Adults: A Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Adults aged 80 years or older.\n* Clinical diagnosis of frailty, defined by a Short Physical Performance Battery (SPPB) score \\\u003C 9.\n* Ability to stand and walk with or without assistive devices.\n* Ability to understand and follow instructions for inspiratory muscle training.\n* Stable medical condition for at least 3 months prior to enrollment.\n* Capacity to provide informed consent or availability of a legal\n\nExclusion Criteria:\n\n* Acute or unstable cardiovascular, respiratory, or metabolic conditions.\n* Severe cognitive impairment that prevents understanding the procedures.\n* Diagnosis of neuromuscular diseases affecting respiratory muscles (e.g., ALS, myopathies).\n* Severe or uncontrolled hypertension (≥180\u002F110 mmHg).\n* Recent thoracic or abdominal surgery (\\\u003C3 months).\n* Severe musculoskeletal disorders limiting participation in training.\n* History of recurrent syncope, severe dizziness, or intolerance to respiratory maneuvers.\n* Any condition judged by the research team to compromise safety or participation.",{"count":62,"type":20},[23],"This study aims to evaluate the effects of an 8-week inspiratory muscle training program on maximal inspiratory pressure and functional capacity in frail older adults aged 80 years and above. Frailty is associated with reduced physical capacity, declines in functional performance, impaired respiratory performance, and a higher risk of disability. Inspiratory muscle training is a simple, low-cost intervention that may improve breathing function, inspiratory muscle strength, and overall health in very old adults, but evidence in this age group remains limited.\n\nParticipants will be randomly assigned to one of two groups: a high-load inspiratory muscle training group or a low-load sham training group. Both groups will use a threshold device and perform 30 breaths once per day, five days per week, for eight weeks. The experimental group will train with progressively increasing resistance (50% to 80% of maximal inspiratory pressure), while the sham group will use a minimal and non-progressive load (15% of maximal inspiratory pressure). All sessions will be supervised and monitored for safety.\n\nThe main goal of the study is to determine whether inspiratory muscle training improves maximal inspiratory pressure (MIP), an established measure of global inspiratory muscle strength. Secondary outcomes include measures of functional capacity, reflecting the ability to perform physical tasks relevant to daily living in very old adults. These outcomes will allow the evaluation of the clinical relevance of improvements in inspiratory muscle strength in this population.\n\nAssessments will be performed before the intervention, immediately after the 8-week program, and again at one and three months after the end of the intervention to examine both immediate and short-term effects. This study may contribute valuable evidence regarding the safety, feasibility, and clinical benefits of inspiratory muscle training in frail very old adults, particularly its impact on inspiratory muscle strength and functional capacity, supporting its potential implementation in rehabilitation and geriatric care.",[66,67,68,69],[71,210,72],"Diaphragm Ultrasound","2026-01-03",{"date":213,"type":43},"2026-01-09",{"date":215,"type":20},"2026-02-01",{"date":217,"type":20},"2026-09-10",{"name":49,"class":50},{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":59,"minAge":89,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":21,"phases":227,"briefSummary":228,"conditions":229,"keywords":231,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":4},"100614937","effectiveness-satisfaction-and-usability-of-virtual-reality-in-the-management-of-postoperative-pain-in-patients-undergoing-knee-arthroplasty-100614937","NCT07286084","Effectiveness, Satisfaction, and Usability of Virtual Reality in the Management of Postoperative Pain in Patients Undergoing Knee Arthroplasty","Inclusion Criteria:\n\n* Adults ≥18 years of age, both sexes\n* Scheduled unilateral knee arthroplasty\n* Adequate cognitive and functional capacity to use virtual reality\n* Signed informed consent\n\nExclusion Criteria:\n\n* Neurological or psychiatric disorders (history of epilepsy, seizures, psychosis, schizophrenia, claustrophobia, tremor, rigidity)\n* Significant visual or hearing impairments that hinder VR use\n* Physical or motor limitations preventing the use of VR headsets or maintaining the required posture\n* Score ≥4 on the 4AT delirium screening tool\n* Pregnancy\n* Recreational drug or alcohol use\n* Inability to complete the intervention protocol",{"count":226,"type":20},45,[23],"The goal of this clinical trial is to evaluate the effectiveness of using virtual reality glasses to reduce the need for rescue analgesia in patients with acute postoperative pain after knee arthroplasty.\n\nThe main questions it aims to answer are:\n\n* What is the impact of virtual reality use on postoperative pain perception as measured by the Visual Analogue Scale (VAS)?\n* What potential adverse effects are associated with the use of virtual reality in the postoperative context?\n* What is the level of satisfaction and acceptance of virtual reality as a complementary strategy for pain management?\n* How does virtual reality influence quality of life and psychosocial variables in patients with acute postoperative pain after knee arthroplasty?",[230],"Knee Arthroplasty",[232,233,234,158],"knee arthroplasty","postoperative pain","acute pain","2025-12-03",{"date":237,"type":43},"2025-12-16",{"date":239,"type":20},"2025-12-27",{"date":241,"type":20},"2026-12-30",{"name":49,"class":50},{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":59,"minAge":89,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":21,"phases":252,"briefSummary":253,"conditions":254,"keywords":256,"overallStatus":160,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":169},"100608339","surgical-management-of-lateral-ankle-instability-modified-brostrm-gould-versus-arthroscopic-allograft-reconstruction-of-the-anterior-talofibular-and-calcaneofibular-ligaments-100608339","NCT07200271","Surgical Management of Lateral Ankle Instability: Modified Broström-Gould Versus Arthroscopic Allograft Reconstruction of the Anterior Talofibular and Calcaneofibular Ligaments.","Surgical Management of Lateral Ankle Instability: Modified Broström-Gould Versus Arthroscopic Allograft Reconstruction of the Anterior Talofibular and Calcaneofibular Ligaments. A Randomized Stratified Clinical Trial.","Inclusion Criteria:\n\nMandatory criteria (all must be marked \"yes\" in a drop-down tab):\n\n* Age \\>18 years\n* Subjective sensation of instability\n* Pathological anterior drawer and varus tilt compared to the contralateral side\n* Magnetic resonance imaging showing lesion of the anterior talofibular ligament (ATFL)\n\nSpecific criteria (must meet at least one, but can meet several, multiple choice option):\n\n* BMI \\>30\n* High athletic demand (regularly participates in pivoting sports)\n* Ligamentous hyperlaxity (Beighton score \\>8)\n* First sprain more than 2 years ago\n* More than 5 sprains per year\n* Subfibular ossicle \\>1 cm\n* MRI with ATFL showing high T2 signal\n* MRI showing disruption\u002Fabsence of ATFL\n\nExclusion Criteria:\n\n* History of previous ankle surgery\n* Tibiotalar osteoarthritis or presence of chondral lesions on magnetic resonance imaging\n* Active infections\n* Contraindications for surgery\n* Pregnancy\n* Lactation\n* Known allergy to bovine collagen\n* Autoimmune connective tissue disease\n* Active oncological process",{"count":251,"type":20},36,[23],"Primary Objective:\n\nTo clarify whether arthroscopic reconstruction with allograft provides tangible benefits over the modified open Broström-Gould technique, or if both are equivalent in efficacy and safety. The clinical AOFAS scale will be used for assessment.\n\nSecondary Objectives:\n\nTo determine if there are differences in health outcomes and patient-perceived pain using the specific SP-36 scale and verbal numeric rating scale (VNRS). Additionally, to assess differences in postoperative complication rates and time to return to daily life activities between the two surgical techniques.\n\nStudy Design:\n\nProspective, randomized, controlled clinical trial with two parallel groups stratified by age and functional demand.\n\nCondition or Disorder Being Studied:\n\nChronic lateral ankle instability.\n\nStudy Population and Sample Size:\n\nThe target population includes subjects diagnosed with chronic lateral ankle instability. The study population consists of patients diagnosed in the Orthopedics consultations at Hospital Infanta Elena who meet the inclusion and exclusion criteria. Based on sample size calculations, a total of 36 patients will be recruited. However, due to the prospective nature and stratification by epidemiological and functional variables, the sample size may be increased to ensure comparable groups in each stratum.\n\nStudy Timeline and Estimated Completion Date:\n\nThe study is expected to begin in the third quarter of 2025. Recruitment is estimated to last 24 months, with a follow-up period of 12 months, for a total duration of 3 years, ending in the third quarter of 2028.",[255],"Ankle Sprain",[257,258,259,260],"ALLOGRAFT","INSTABILITY","ANKLE","LIGAMENT","2025-09-26",{"date":263,"type":43},"2025-10-01",{"date":265,"type":43},"2025-09-01",{"date":267,"type":20},"2028-09-01",{"name":49,"class":50},{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":58,"sex":59,"minAge":89,"maxAge":276,"enrollmentInfo":277,"targetDuration":4,"studyType":21,"phases":279,"briefSummary":281,"conditions":282,"keywords":284,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":4},"100577912","phase-1-effect-of-a-vegan-mediterranean-diet-on-cardiometabolic-biomarkers-functional-capacity-and-quality-of-life-in-patients-with-fibromyalgia-100577912","NCT06804460","Effect of a Vegan Mediterranean Diet on Cardiometabolic Biomarkers, Functional Capacity, and Quality of Life in Patients with Fibromyalgia","FIBROVEG","Inclusion Criteria:\n\n* Adults aged between 18 and 50 years.\n* Participants with a Fibromyalgia diagnosis according to the American College of Rheumatology (ACR) criteria.\n* Functional independence.\n* Non-smokers.\n* Low alcohol consumption (\\\u003C1 serving\u002Fday).\n* Pharmacological treatment stabilized for at least 4 weeks prior to the start of the study.\n\nExclusion Criteria:\n\n* Pregnant, lactating, or menopausal women.\n* Physical condition that prevents the performance of functional capacity tests.\n* Change in pharmacological therapy during the intervention period.\n* Concomitant inflammatory conditions.","50 Years",{"count":278,"type":20},28,[280],"PHASE1","This study aims to evaluate the effect of a vegan Mediterranean diet compared to a traditional Mediterranean diet on inflammatory biomarkers, functional capacity, and quality of life in patients with fibromyalgia.",[283],"Fibromyalgia",[283],"2025-01-31",{"date":287,"type":43},"2025-02-03",{"date":289,"type":20},"2025-03-01",{"date":291,"type":20},"2025-04-21",{"name":49,"class":50},{"id":294,"slug":295,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":11,"sex":15,"minAge":89,"maxAge":300,"enrollmentInfo":301,"targetDuration":4,"studyType":21,"phases":303,"briefSummary":304,"conditions":305,"keywords":307,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":313,"completionDateStruct":314,"leadSponsor":316,"locationsCount":4},"100577913","effect-of-aerobic-exercise-on-clinical-symptoms-during-the-ovarian-cycle-100577913","NCT06804473","Effect of Aerobic Exercise on Clinical Symptoms During the Ovarian Cycle","OVARIANEXERCYC","Inclusion Criteria\n\n* Age between 18 and 26 years.\n* Sedentary lifestyle.\n* Body Mass Index (BMI) between 18.5 and 26 kg\u002Fm².\n* Regular menstrual cycle (24-38 days).\n* Menstrual pain intensity ≥ 4 mm on the Visual Analog Scale (VAS).\n* Presence of anxiety or stress.\n\nExclusion Criteria\n\n* Pregnancy or breastfeeding within the last 3 months.\n* Amenorrhea.\n* Use of oral contraceptives in the last 3 months.\n* Presence of an intrauterine device (IUD).\n* Regular alcohol consumption.\n* Active smoking.\n* Chronic endocrine, digestive, neurological, or uncontrolled cardiovascular diseases, and\u002For psychiatric disorders.\n* Any medical diagnosis contraindicating physical exercise.","26 Years",{"count":302,"type":20},44,[23],"This study aims to evaluate the effects of moderate-to-high intensity aerobic exercise on primary dysmenorrhea, a common condition characterized by painful menstrual cramps.\n\nThe study will involve women diagnosed with primary dysmenorrhea, who will be randomly assigned to one of two groups:\n\nExperimental Group: Participants will perform a supervised aerobic exercise program tailored to their fitness level.\n\nControl Group: Participants will continue their usual care without any additional interventions.\n\nThe study will run from February 2025 to April 2025 in Madrid, Spain. Before starting, all participants will complete a questionnaire to gather information about their demographics, menstrual cycle characteristics, medical history, and physical activity levels. This will help ensure an accurate diagnosis of primary dysmenorrhea and provide baseline data for comparison.\n\nParticipants will be randomly assigned to their groups using a computer-generated sequence, with allocation managed confidentially to avoid bias. The study's single-blind design ensures that the evaluators will not know the group assignments.\n\nThe goal of this research is to determine whether regular aerobic exercise can serve as an effective, non-pharmacological intervention to reduce the severity of menstrual pain and improve the quality of life for women with primary dysmenorrhea. The findings will inform patients, families, and healthcare providers about potential lifestyle strategies to manage this condition.",[306],"Primary Dysmenorrhea",[308,101,309,310],"dysmenorrhea","pain","aerobic exercise","2025-01-27",{"date":287,"type":43},{"date":289,"type":20},{"date":315,"type":20},"2025-06-30",{"name":49,"class":50},""]