[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad Miguel Hernandez de Elche\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":318},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,45,80,103,131,161,193,233,261,290],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":25,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644193","impact-of-changing-the-appearance-of-oral-antineoplastics-on-adherence-and-continuity-of-treatment-patient-reported-health-outcomes-and-patient-experience-of-care-100644193",false,"NCT07664683","Impact of Changing the Appearance of Oral Antineoplastics on Adherence and Continuity of Treatment, Patient-reported Health Outcomes, and Patient Experience of Care","Objective 1:\n\nInclusion criteria:\n\nANEOs included in the pharmacotherapeutic guide of the three hospitals for two years of follow-up (June 2025-2027) will be included.\n\nObjectives 2-5:\n\nInclusion criteria:\n\n* Patients on treatment for at least 6 months with one of the following ANEOs will be included: capecitabine (L01BC06) (not used as adjuvant in short cycles), imatinib (L01EA01), everolimus (L04AA18), abiraterone (L02BX03) and lenalidomide (L04AX04), at the time of a change in their usual treatment (from brand to generic or between two generics).\n* Patients on treatment with ANEOs who meet the established criteria and who change their treatment from brand to generic or from one generic to another generic during the study period may also be included.\n\nExclusion criteria:\n\n* Individuals who collect medication for others and those who are institutionalised will be excluded.\n* Patients who have been admitted to hospital in the last 4 weeks are also excluded, due to the increased control of their medication.\n\nObjective 2( Qualitative analysis)\n\n\\- Spanish Patient Forum","ALL","18 Years",{"count":18,"type":19},334,"ESTIMATED","OBSERVATIONAL","Oral chemotherapy is a convenient and flexible option for cancer treatment that can improve patients quality of life and increase adherence to treatment compared to traditional intravenous chemotherapy. However, since patients are responsible for taking the medication, there can be issues with continuity and adherence. Like other medications, generics of existing oral chemotherapy have emerged, which help reduce costs and improve access to this therapy. These generics contribute to a more sustainable healthcare system, so it is necessary to implement effective strategies for their adoption.\n\nAlthough generic treatments have been shown to be just as effective as the original drug, there is no regulation requiring the pill to have the same shape and color as the original (what we refer to as appearance). Additionally, the packaging of the treatment is different as it is specific to each brand. Therefore, a patient on a specific treatment may switch from the original medication to a generic or from one generic to another, which may have a different appearance in both the pill and the packaging.\n\nIt has been observed that these changes can lead to medication errors or a loss of patient confidence, resulting in decreased continuity and adherence to treatment. These issues have been seen with other medications for chronic diseases but have not been studied in cancer patients to date. In these patients, despite the nature of the disease suggesting they would be adherent to treatment, previous studies have shown that this is not the case, with only about 70% of patients being adherent. This lack of adherence affects treatment efficacy, increases the risk of disease relapse, and therefore negatively impacts patient s quality of life and survival while also increasing costs.\n\nTherefore, this study focuses on evaluating whether these changes in pill appearance and\u002For packaging impact treatment continuity and adherence, as well as other relevant patient outcomes and their experience with the healthcare received. Additionally, we want to analyze whether there are patient variables (such as health literacy, age, or clinical variables) that influence the impact of these changes. Given the differences in adherence between men and women, it is essential to conduct these analyses separately for both genders.\n\nThe results obtained from this study will contribute to the development of educational strategies for managing oral chemotherapy by patients and healthcare professionals. Additionally, new evidence will be generated to allow decision-makers to establish policies, either by choosing treatments with the least change in appearance or by regulating the appearance of treatments. All of this will contribute to greater treatment effectiveness, improved patient quality of life, and a lower rate of disease recurrence.",[23,24],"Adherence, Patient","Cancer",[26,27,28,29,30,31],"adherence","patient care","PROMS","PREMS","oral antineoplastic drug","appearance","RECRUITING","2026-06-16",{"date":35,"type":36},"2026-06-24","ACTUAL",{"date":38,"type":36},"2025-12-08",{"date":40,"type":19},"2027-06-29",{"name":42,"class":43},"Universidad Miguel Hernandez de Elche","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":15,"minAge":16,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":44},"100637952","the-role-of-fatigue-associated-with-strength-training-in-exercise-induced-hypoalgesia-100637952","NCT07577622","The Role of Fatigue Associated With Strength Training in Exercise-induced Hypoalgesia","The Role of Fatigue Associated With Different Protocols of Strength Training in Exercise-induced Hypoalgesia: A Randomized Crossover Trial","FATIGUEIH","Inclusion Criteria:\n\n* Healthy, asymptomatic subjects\n* Being physically active\n\nExclusion Criteria:\n\n* Experiencing episodes of acute pain in any part of the body.\n* Having chronic pain or a recent history of chronic pain conditions considered resolved within the last 6 months.\n* Having a serious illness or inability to perform moderate or intense physical activity.\n* Having taken pain relievers, fever reducers, anti-inflammatory drugs (NSAIDs), steroids, opioids, or similar medications in the 24 hours before a session.\n* Having consumed alcohol or other psychoactive substances, caffeine, or other stimulants in the 24 hours before a session.\n* Having performed tiring physical activity or strength exercise in the 24 hours before a session.",true,"45 Years",{"count":56,"type":19},27,"INTERVENTIONAL",[59],"NA","Strength exercise is an active and dynamic activity that involves applying force against a resistance. This produces fatigue, seen as a reduced ability to apply force during and after the exercise, and perceived effort, which is a person's subjective feeling of how hard they are working.\n\nStrength exercise can also be used for therapy, as it has many benefits for different parts of the body. One of these is changing how the individual feels pain. It has been shown that doing strength exercises can reduce pain perception, a phenomenon called exercise-induced hypoalgesia (EIH), although the exact physical reasons and the amount of exercise needed to cause this effect are not yet known.\n\nOne of the most studied exercises in this area is the leg extension machine. This is a specific exercise where the legs move freely (open kinetic chain) and the machine guides the movement, which helps keep things stable and limits the effect of other factors. It is usually used to strengthen and grow the muscles in the front of the thigh, especially the quadriceps, but it can also be used to study the effects on EIH.\n\nThe main goal of this study is to see if fatigue and perceived effort during strength exercise are important for EIH to happen in healthy people. Participants will complete 3 sessions, at least 7 days apart. These will include a control session and 2 sessions designed to show different levels of fatigue. Before, during, and after the sessions, the investigators will measure pain sensitivity, isometric strength, and perceived effort. Also, there will be a test to find the maximum weight for 10 repetitions and several questionnaires to collect basic info (sex, age, height...), weekly physical activity, experience with strength training, and other factors like sleep quality, stress, and mood. All this information will be completely anonymous when the study results are shared.",[62,63],"Exercise Induced Hypoalgesia","Healthy Adult Volunteer",[65,66,67,68,69,70],"Fatigue","Exercise","Hypoalgesia","Strength training","Healthy adult","leg extension","NOT_YET_RECRUITING","2026-05-05",{"date":74,"type":36},"2026-05-11",{"date":76,"type":19},"2026-05-15",{"date":78,"type":19},"2027-06-30",{"name":42,"class":43},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":57,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},"100284497","development-of-a-cortical-visual-neuroprosthesis-for-the-blind-100284497","NCT02983370","Development of a Cortical Visual Neuroprosthesis for the Blind","Pilot Study for the Development of a Cortical Visual Neuroprosthesis for the Blind Based on Intracortical Microelectrodes","CORTIVIS","Inclusion Criteria:\n\n* Participant is capable and willing to provide informed consent for participation in the trial.\n* Severe visual impairment with bilateral visual loss.\n* Greater than 18 years of age.\n* General health: excellent.\n* Following a general physical and neurological examination, patient must have normal serum electrolytes, C-reactive protein, complete blood count and PT and PTT.\n* No history of stroke, seizure, coagulopathy, cardiac arrhythmias or ischemia, pulmonary, hepatic or renal disease, nor transmissible viruses such as hepatitis or HIV.\n* Stable dose of current regular medication for at least four weeks prior to trial entry.\n* Able to perform the study during the full time period of up to 6 months.\n\nSpecial consideration will be given to patients with (1) detailed medical histories, including documentation of the onset, mechanism and evolution of the blindness; (2) lower risks associated with surgery; and (3) no psychiatric disorders or other mental disabilities.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>70.\n* Period of appropriate visual functions \\\u003C 12 years \u002Flifetime.\n* For medical reasons: Individuals with a history of seizure disorders, coagulopathy, cardiac arrythmias or ischemia, pulmonary, hepatic or renal disease, and any other neurological disorder. Patients who carry a transmissible virus such as hepatitis and individuals with HIV-related neuropathies.\n* Vulnerable subject groups (e.g., pregnant women, prisoners, etc.).\n* Persons unable to give written informed consent prior to participation in the study.\n* Not able to perform the study during the full time period (at least 3 months).\n* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial.","70 Years",{"count":90,"type":19},5,[59],"The objective of this study is to evaluate the usefulness of a cortical visual prosthesis based on intracortical microelectrodes to provide a limited but useful sense of vision to profoundly blind. This pilot study will provide important information on safety and efficacy for the development of an useful cortical visual neuroprosthesis for the blind.",[94],"Blindness","2026-04-28",{"date":72,"type":36},{"date":98,"type":36},"2019-10-01",{"date":100,"type":19},"2028-10",{"name":42,"class":43},2,{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":57,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":44},"100631276","effects-of-percutaneous-electrical-stimulation-in-patients-with-chronic-supraspinatus-tendinopathy-100631276","NCT07498569","Effects of Percutaneous Electrical Stimulation in Patients With Chronic Supraspinatus Tendinopathy","Effects of Percutaneous Electrical Stimulation Combined With a Therapeutic Exercise Program in Patients With Chronic Supraspinatus Tendinopathy","Inclusion Criteria:\n\n* Subjects attending the shoulder unit of the traumatology and orthopedic surgery service at Clínica HLA Vistahermosa (TraumaVist) who are clinically diagnosed with supraspinatus tendinopathy (M75.1 Rotator cuff tendinopathy - ICD-10), according to the following criteria (Desmeules et al., 2025).\n\n  * Participants of both sexes, aged between 18 and 65 years, diagnosed with chronic supraspinatus tendinopathy, or any of the related terms, provided they also meet the conditions detailed below.\n  * Painful symptoms associated with the insertion area of the supraspinatus tendon, present for at least 3 months, of non-traumatic origin, which increase with palpation (score equal to or greater than 3\u002F10 on a numerical pain scale) and with resisted movements, and not associated with signs of nerve root irritation.\n  * Structural changes in the supraspinatus tendon (tendinosis), observed via ultrasound or MRI, and confirmed by a specialist physician.\n  * Positive results in at least 2 of the 5 assessment tests: Hawkins-Kennedy, Neer, Jobe, painful arc of motion, and resisted external rotation.\n  * Attend the center, referred by a specialist in traumatology and orthopedics, with a prescription for physiotherapy treatment.\n\nExclusion Criteria:\n\n* Individuals with any of the following circumstances will be excluded:\n\n  * Intratendinous calcification in the supraspinatus muscle.\n  * Partial or complete tear of any rotator cuff structure.\n  * Serious illnesses, diabetes, or systemic inflammatory disease.\n  * Pregnant women (at any stage of pregnancy).\n  * Presence of concomitant pathology in the affected shoulder joint complex at the time of recruitment (previous trauma, capsulitis, fracture and dislocation, history of surgery, entrapment neuropathies, among others).\n  * Regular analgesic or anti-inflammatory pharmacological treatment, including corticosteroid injections in the area, within the 6 months prior to recruitment.\n  * Difficulty understanding and following the intervention program, in any of its modalities (percutaneous electrical stimulation and exercises). • Individuals with belonephobia (fear of needles), or a contraindication for the application of either percutaneous electrical stimulation technique (EP or PENS).\n  * High scores on the Tampa - TSK-11 kinesiophobia scale (≥36 points).","65 Years",{"count":112,"type":19},64,[59],"The aim of this clinical trial is to evaluate the effects of two percutaneous stimulation techniques-Percutaneous Electrical Stimulation (PENS) and Percutaneous Electrolysis (PE)-combined with a therapeutic exercise (TE) program for the shoulder joint complex, on pain and function in individuals with chronic supraspinatus tendinopathy.\n\nThe main question this study seeks to answer is: Would incorporating percutaneous electrical stimulation (PENS) of the axillary and suprascapular nerves and galvanic percutaneous stimulation (PE) of the supraspinatus tendon into a therapeutic exercise (TE) program for the shoulder joint complex improve therapeutic outcomes in terms of pain, function, and upper limb disability? Based on an exercise program in all groups, researchers will compare the efficacy of active PENS and PE, as well as placebo, in all their combinations.\n\nParticipants will undergo a 12-week exercise program, during which they will receive four sessions (one session per week) of active percutaneous electrical stimulation or a placebo during the first month.\n\nParticipants will:\n\n* Visit the center on four separate occasions for results measurement.\n* Keep a session log to verify adherence to the exercise program.",[116],"Supraspinatus Tendinopathy",[118,119,120,121,122],"Chronic pain","Shoulder tendinopathy","Percutaneous Electrolysis","Percutaneous Electrical Nerve Stimulation","Therapeutic exercise","2026-03-25",{"date":125,"type":36},"2026-03-27",{"date":127,"type":19},"2026-09-01",{"date":129,"type":19},"2027-06-01",{"name":42,"class":43},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":53,"sex":15,"minAge":138,"maxAge":4,"enrollmentInfo":139,"targetDuration":141,"studyType":20,"phases":4,"briefSummary":142,"conditions":143,"keywords":146,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":44},"100626580","cancer-literacy-education-and-awareness-resources-for-prostate-care-100626580","NCT07437482","Cancer Literacy Education and Awareness Resources for Prostate Care","CLEAR-PC","Inclusion Criteria:\n\n* Adults aged 40 years or older\n* Member of the general population, patient, caregiver, or healthcare professional eligible for the study component\n* Able to understand and communicate in the language used at the study site\n* Able to provide informed consent\n* Willing to participate in surveys, interviews, workshops, or intervention activities as applicable\n* Access to digital or non-digital materials required for the intervention, depending on study arm\n\nExclusion Criteria:\n\n* Participation in another study that could interfere with the outcomes of this study","40 Years",{"count":140,"type":19},3100,"3 Years","The CLEAR-PC project addresses the critical issue of low health literacy in prostate cancer prevention and care, recognising that inadequate health literacy leads to difficulties in understanding complex medical information, limits shared decision making, and increases health inequalities. Given the high prevalence and complexity of prostate cancer, the project aims to design and development of a comprehensive strategy to improve health literacy in the Prostate cancer prevention and care, considering individual capacities, the role of healthcare professionals and organisations, and the influence of social and cultural contexts. In the design and development of this new strategy, the investigators apply both action research and cocreation methodologies because by involving all stakeholders (general population, vulnerable population patients, health professionals, policy makers and other target groups), we ensure that the resulting strategy is user-centred, implementable and responsive to their needs. The design and development of the new strategy will follow a systematic cycle: (a) problem diagnosis by assessing individual contexts, healthcare professionals, organisational aspects and the social framework; (b) adaptation of existing health literacy tools to the specific context of prostate cancer prevention and care, integrating them into a new strategy, followed by evaluation of their usability and acceptability; and (c) observation of results in practice and reflection. Co-creation will be a critical component throughout this process, ensuring that stakeholders are actively involved at every stage, from diagnosis of challenges to refinement and validation of solutions. The consortium, composed of institutions from Spain, Portugal, Croatia, Belgium, the Netherlands and Cyprus, leverages multidisciplinary expertise to create digital and non-innovative tools and educational resources to address public health disparities, reduce misinformation and support decision-making on prostate cancer prevention and care.",[144,145],"Health Literacy","Prostate Cancer",[147,148,149,150,151,152],"Prostate cancer","Health literacy","Diagnosis","Screening","Treatment","Palliative care","2026-02-28",{"date":155,"type":36},"2026-03-03",{"date":157,"type":19},"2026-03",{"date":159,"type":19},"2028-09",{"name":42,"class":43},{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":110,"enrollmentInfo":169,"targetDuration":4,"studyType":57,"phases":171,"briefSummary":172,"conditions":173,"keywords":179,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":44},"100584442","effects-of-education-and-exercise-on-pain-psychosocial-factors-and-upper-limb-function-in-non-specific-neck-pain-100584442","NCT06889389","Effects of Education and Exercise on Pain, Psychosocial Factors, and Upper Limb Function in Non-specific Neck Pain.","Effects of Pain Neuroscience Education and Therapeutic Exercise on Pain, Catastrophizing, Kinesiophobia and Upper Limb Function in Patients With Non-specific Neck Pain.","PNE-EXNP","Inclusion Criteria:\n\n* Subjects aged between 18 and 65 years\n* Subjects with non-specific neck pain at the time of the intervention, scoring at least 3 on the NPRS scale.\n\nExclusion Criteria:\n\n* Pregnancy\n* Severe illnesses: diabetes, cancer, neurological conditions, depression, etc.\n* Subjects impairments or disorders\n* Subjects who have received physiotherapy treatment within the last month\n* Subjects currently undergoing concurrent physiotherapy treatment for this condition\n* Subjects with specific neck pain, such as any traumatic pathology, whiplash, or diagnoses associated with neurological compromise or peripheral nerve damage\n* Physiotherapy students or professional physiotherapists",{"count":170,"type":19},81,[59],"Pain neuroscience education is currently one of the techniques being explored in physiotherapy for pain management. The benefits of this technique are gradually becoming evident in various published studies. So far, it has been widely studied for its short-term effects, but the education provided has typically been generic, not focused on exercise. However, it is suggested that this technique should be combined with exercise to achieve the expected outcomes. Therefore, pain education should be tailored to the specific physical activities the subject will perform to maximise its effectiveness. The primary aim of this study is to analyse the outcome of combining exercise with tailored pain neuroscience education on aspects such as pain, kinesiophobia, catastrophizing, exercise conceptualization, and upper limb function in subjects with neck pain. The secondary aim is to evaluate the relationship between kinesiophobia and catastrophizing and their impact on the results of various upper limb performance tests. Finally, the effects of therapeutic exercise alone will be compared with those of therapeutic exercise combined with pain neuroscience education, focusing on pain, kinesiophobia, catastrophizing, and exercise conceptualization. A double-blind, randomised clinical trial has been designed, in which three intervention protocols will be applied to 81 subjects with non-specific neck pain: education with exercise, exercise alone, and placebo alone. Subjects with non-specific neck pain who meet the inclusion criteria will be enrolled. Demographic characteristics of the subjects, as well as pain, kinesiophobia, catastrophizing, and upper limb performance test scores, will be assessed. This study aims to explore the potential relevance of a pain neuroscience education session prior to therapeutic exercise, as well as to influence the clinical recommendations made by clinicians during treatment.",[174,175,176,177,178],"Neck Pain","Patient Education","Exercise Therapy","Fear","Pain",[180,181,182,183,184],"Neck pain","Pain neuroscience education","Exercise therapy","Kinesiophobia","Pain catastrophizing","2025-12-19",{"date":187,"type":36},"2025-12-29",{"date":189,"type":36},"2025-03-28",{"date":191,"type":19},"2026-10-30",{"name":42,"class":43},{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":197,"acronym":198,"eligibilityCriteria":199,"healthyVolunteers":53,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":57,"phases":202,"briefSummary":203,"conditions":204,"keywords":214,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":102},"100611237","cocreating-action-to-improve-rationality-in-the-health-system-100611237","NCT07237971","Cocreating Action to Improve Rationality in the Health System","CAIR","Survey general population:\n\nA representative population survey of adult (aged 18 years and over) who are residents in the Municipal District 2 of Elche (Spain).\n\nSurvey community pharmacies:\n\nIndividuals who visit the pharmacies collaborating in the Municipal District 2 of Elche (Spain) to obtain any of the medications, aged 18 years and over for three a priori established medication groups.\n\n* Group 1 (Antidepressants and Anxiolytics): N05B, N05C, N06A.\n* Group 2 (Cardiovascular disease risk factor medication): A10B (antidiabetics), C10A (cholesterol-lowering drugs), C07A, C09A, C03C, C08C (antihypertensives).\n* Group 3 (Antibiotics): J01\n\nHealth service data from primary care:\n\nA series of aggregate indicators will be collected from the electronic information systems of the regional health authorities (Conselleria de Sanidad de la Generalitat Valenciana), which hosts information on both prescriptions made by physicians and those dispensed in the community pharmacies of the Valencian Community. These indicators will be calculated for individuals aged 18 years and over for groups 2 and 3, and 12 years and over for group 1 using aggregate data from health system's registries and, therefore, not considering 12 years old as minimum age limit of the eligible participants in the present study protocol registry. Furthermore, aggregate data about the number of consultations will be collected in the two primary care facilities in the study area for individuals aged 18 and over.\n\nQualitative methods and cocreation procedure:\n\nFocus groups, sociograms and in-depth interviews will include 6-8 participants and last approximately 90 minutes. Participation in the co-creation process will be open, voluntary, and will depend on the interest of individuals and entities in the area. Eligibility criteria:\n\n* People aged 18 and over who are residents or have a job or family connection in the Municipal District 2 of Elche (Spain) who are interested in participating, wish to be actively involved in the co-creation, planning, and implementation of community initiatives, and are available to attend the conferences, meetings, and workshops.\n* Representatives from community institutions and associations, including professionals from the Elche Public Health Center, primary care teams in the area, Elche Council staff, as well as professionals and volunteers from NGOs and other local organizations with experience in community work in the district.",{"count":201,"type":19},4000,[59],"Despite widespread recognition of social, economic, or environmental health determinants, health action remains heavily dominated by individual-level solutions (e.g., medication, patient counselling, vaccination). This study aims to stimulate changes in health system functioning by demonstrating how the cocreation of actions to address psychological well-being, cardiovascular health, and antimicrobial resistance from within the community can alleviate the burden on primary care services, reduce medicalisation and increase health equity.\n\nThe scientific approach uses mixed methods and incorporates theory from multiple disciplines. This study will appraise how the current system addresses psychological well-being, cardiovascular (CV) health, and rational use of antibiotics using a population survey, a survey of patients collecting their medication at community pharmacies, aggregate health service indicators on medication consumption and primary care consultations, and qualitative methods exploring stakeholders' perceptions.The investigators will undertake community-based participatory research to engage citizen scientists in the cocreation of community-led actions to promote psychological well-being, CV health, and prevent antimicrobial resistance. The design, implementation, and evaluation of the actions will apply an assets-based approach and apply theories and frameworks from implementation science in an iterative manner over 3 years. Finally, the impact of the cocreated actions will be analysed, considering effectiveness and broader contextual issues such as initiative adoption, implementation, and maintenance. The investigators will use a before-after comparison of survey indicators, an interrupted time-series analysis of health service data and qualitative analysis.\n\nThe goal is to demonstrate how the integration of community action with attention to the social determinants of health, can lead to a more rational approach to health care and ultimately improve health and health equity.",[205,206,144,207,208,209,210,211,212,213],"Health-Related Quality-of-Life","Social Capital","Community Based Participatory Research","Antibiotic Prescription","Mental Health Literacy","Cardio Vascular Disease","Antimicrobial Drug Resistance","Well-being","Health Equity",[215,216,217,148,218,219,220,221,222,223,224],"Community health","Cocreation action","Health system","Social capital","Community capital","Antibiotic drug use","Cardiovascular drug use","Psychotropic drug use","Health-related quality of life","Health equity","2025-11-24",{"date":227,"type":36},"2025-12-02",{"date":229,"type":36},"2025-10-21",{"date":231,"type":19},"2029-04-01",{"name":42,"class":43},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":57,"phases":243,"briefSummary":244,"conditions":245,"keywords":247,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":44},"100604228","home-based-graded-repetitive-arm-supplementary-program-for-quality-of-life-and-functional-upper-limb-recovery-100604228","NCT07146789","Home-based Graded Repetitive Arm Supplementary Program for Quality of Life and Functional Upper Limb Recovery","Effectiveness of the Home-Based Graded Repetitive Arm Supplementary Program Combined With Occupational Therapy Versus Conventional Occupational Therapy Alone on Quality of Life and Upper Limb Function After Stroke: A Randomized Controlled Trial","REC-HOMEGRASP","Inclusion Criteria:\n\n* Be of legal age.\n* Have suffered only one stroke and be clinically stable.\n* At least 3 months must have passed since the stroke and less than 12 months.\n* Signing of informed consent\n* Be able to communicate any adverse effects (e.g. shoulder pain)\n* Be able to follow instructions and perform the exercises independently for one hour. If they are not able to do so, have the help of a caregiver to ensure that the exercises are performed.\n* Perform at least 10º of active wrist or finger extension.\n* Ability to raise the scapula of the affected upper limb against gravity.\n\nExclusion Criteria:\n\n* Having neurological conditions other than stroke.\n* Experiencing excessive pain in the affected upper limb that prevents the patient from correctly performing the exercises proposed in the programme. Visual Analogue Scale (VAS \\> 7).\n* Having a visual perception deficit that prevents the patient from correctly performing the exercises proposed in the programme.\n* Excessive muscle tone (spasticity or hypertonia) that prevents the person from correctly performing the exercises proposed in the programme. Asworth \\> 2.\n* A Folstein Mini-Mental State Examination (MMSE) score of ≥22 is required.",{"count":242,"type":19},70,[59],"In post-stroke rehabilitation of the affected upper limb, increasing treatment intensity has been shown to lead to better outcomes compared to conventional approaches with fewer hours of therapy per day and week. However, logistical, human, and material constraints in neurorehabilitation centres often limit the feasibility of increasing treatment intensity.\n\nThe GRASP programme (Graded Repetitive Arm Supplementary Program) is a home-based exercise intervention grounded in motor learning principles and conducted weekly under the supervision of an occupational therapist. This strategy enables the intensity of upper limb rehabilitation to be increased by up to seven additional hours per week.\n\nThis project aims to evaluate the effectiveness of the Spanish version of the HomeGRASP programme, implemented as an adjunct to conventional occupational therapy, in improving quality of life, autonomy, and upper limb functionality in people after stroke. To this end, a single-blind, randomised controlled clinical trial will be conducted. Participants in the experimental group will receive conventional occupational therapy in addition to the HomeGRASP programme performed at home, while those in the control group will receive only conventional therapy. The treatment period for both groups will last eight weeks.\n\nParticipants will be assessed at baseline and after the 8-week intervention period by a blinded evaluator. The primary outcomes will include changes in quality of life and upper limb functionality, measured using the CAVIDACE scale and the Wolf Motor Function Test. Secondary outcomes will include upper limb dexterity and personal autonomy, assessed using the Box and Block Test, Purdue Pegboard Test, Motor Activity Log-30, Duruöz Hand Index, and the Functional Independence Measure (FIM).",[246],"Stroke With Hemiparesis",[248,249,250,251,252],"stroke","hemiparesis","upper limb","upper extremity","recovery","2025-08-25",{"date":255,"type":36},"2025-08-28",{"date":257,"type":36},"2025-04-01",{"date":259,"type":19},"2027-02-28",{"name":42,"class":43},{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":267,"eligibilityCriteria":268,"healthyVolunteers":53,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":269,"targetDuration":4,"studyType":57,"phases":271,"briefSummary":272,"conditions":273,"keywords":278,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":44},"100510668","mindfulness-in-university-students-ateneu-program-100510668","NCT05929430","Mindfulness in University Students. ATENEU Program","Effects of a Mindfulness Program on the Occupational Balance and Mental Health of University Students. Protocol for a Randomized Controlled Trial Study. ATENEU Program (Mindfulness in University Students)","ATENEU","Inclusion Criteria:\n\n* being 18 years old or older\n* being a degree, master or doctorate student at Miguel Hernández University\n* speaking fluent Spanish\n* signing the informed consent form\n* having attended at least 4 of the 6 sessions (66% of the program)\n* internet access from a computer or smartphone to complete the online assessments and formal practices during the program.\n\nExclusion Criteria:\n\n* miss more than 2 out of 6 sessions (33% of the program)\n* present a severe mental disorder in active phase diagnosed by a health professional (e.g., schizophrenia, bipolar disorder)\n* are under the influence of alcohol or other drugs during sessions and\u002For assessments (determined by the program instructor)\n* participate in another standardized meditation program during the study period\n* withdrew before starting the intervention.\n* Additionally, should any participants require psychological or psychiatric treatment during the study, they will be excluded and referred to specialized care services.",{"count":270,"type":19},174,[59],"The study aims to examine the effects of a mindfulness-based intervention and a mindfulness-based intervention with virtual reality on occupational balance and on the reduction of psychological distress in university students (i.e. stress, anxiety and depression). The specific objectives will be to examine the effects of the intervention on other variables related to mental health, psychological functioning and occupations, and their maintenance at three months.",[274,275,276,277],"Occupational Balance","Mental Health Wellness","University Students","Burnout, Student",[279,274,280,276,281],"Mindfulness","Mental Health","Burnout Student","2024-12-19",{"date":284,"type":36},"2024-12-24",{"date":286,"type":36},"2023-11-02",{"date":288,"type":19},"2027-12",{"name":42,"class":43},{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":296,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":298,"targetDuration":4,"studyType":57,"phases":300,"briefSummary":301,"conditions":302,"keywords":307,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":44},"100555350","improving-therapeutic-adherence-in-cardiovascular-secondary-prevention-100555350","NCT06510946","Improving Therapeutic Adherence in Cardiovascular Secondary Prevention.","Efficacy of an Intervention to Increase Therapeutic Adherence in Patients With Secondary Prevention for Cardiovascular Disease.","AT-PSC","Inclusion Criteria:\n\n* Patients of both sexes, aged over 18 years old, who, after reading the patient information sheet, provide written informed consent.\n* Patients in secondary prevention receiving daily single-dose angiotensin converting enzyme inhibitors\u002FAngiotensin II receptor blockers, acetylsalicylic acid, and statins for 6 months or more.\n* Diagnosis of any of the following cardiovascular diseases: cerebrovascular disease, ischemic heart disease, or peripheral vascular disease.\n* Patients under follow-up at our primary care center.\n* Patients identified with therapeutic adherence deficiency, defined as Haynes-Sackett test supplemented with Medication Possession Ratio (MPR) \\\u003C 80% for any of the 3 drugs in the previous 6 months.\n\nExclusion Criteria:\n\n* Patients who refuse to participate.\n* Incomplete completion of informed consent.\n* Language barrier.\n* Patients diagnosed with psychiatric, psychological, neurological, and\u002For social problems that hinder intervention or follow-up.\n* Life expectancy less than one year.\n* Patients whose treatment is managed by a caregiver (professional or family member).\n* Patients with Barthel Index \\\u003C60.\n* Institutionalized patients.\n* Patients currently participating in similar research studies.",{"count":299,"type":19},90,[59],"The goal of this open label randomized controlled trial is to evaluate the efficacy of an intervention through health education based on the Chronic Care Model's implementation to increase therapeutic adherence in patients with secondary prevention for cardiovascular disease. The main questions it aims to answer are:\n\n* Null hypothesis (H0): In patients in cardiovascular secondary prevention, an intervention based on the application of the Chronic Care Model does not improve therapeutic adherence to the 3 preventive drugs: Angiotensin converting enzyme inhibitors\u002FAngiotensin II receptor blockers, acetylsalicylic acid, and statins.\n* Alternative hypothesis (H1): In patients in cardiovascular secondary prevention, an intervention based on the application of the Chronic Care Model improves therapeutic adherence to the 3 preventive drugs: Angiotensin converting enzyme inhibitors\u002FAngiotensin II receptor blockers, acetylsalicylic acid, and statins.\n\nResearchers will compare intervention group (health education, use of mobile phones, personalized dosage system) to the control group (routine follow-up).",[303,304,305,306],"Cardiovascular Diseases","Chronic Disease","Secondary Prevention","Coronary Disease",[308,309],"Treatment Adherence and Compliance","Primary Health Care","2024-07-18",{"date":312,"type":36},"2024-07-19",{"date":314,"type":19},"2025-01",{"date":316,"type":19},"2026-01",{"name":42,"class":43},""]