[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad Nacional Andres Bello\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":205},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,86,116,146,177],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644545","inspiratory-muscle-training-for-people-with-heart-failure-100644545",false,"NCT07672041","Inspiratory Muscle Training for People With Heart Failure","Efficacy of an Inspiratory Muscle Training Protocol With Resistive Airflow Loading on Exercise Capacity, Respiratory Muscle Strength and Quality of Life in Individuals With Heart Failure: a Randomized Clinical Trial","Inclusion Criteria:\n\n* History of symptomatic heart failure (NYHA functional class I and III).\n* Participants able to understand and respond to the instructions given in the study\n* Participants with stable disease at the moment of inclusion in this study.\n* Unaltered dose and type of medication up to three months before the start of the study\n\nExclusion Criteria:\n\n* Participants unable to perform a valid baseline cardiopulmonary exercise test.\n* Participants with unstable angina, acute myocardial infarction, and\u002For heart surgery within the past three months.\n* Participants with other concomitant cardiac or neurological disease.\n* Participants with difficulties in maintaining a proper mouth seal or unable to avoid air leakage during pulmonary function testing.\n* Participants in other non-pharmacological study will be also excluded.\n* Current smokers.\n* Cardiac acute decompensation.","ALL","18 Years","80 Years",{"count":20,"type":21},108,"ESTIMATED","INTERVENTIONAL",[24],"NA","Heart failure is frequently associated with inspiratory muscle weakness, which contributes to dyspnea, reduced exercise capacity, impaired quality of life, and adverse cardiovascular outcomes. Although inspiratory muscle training (IMT) is a recommended adjunct to cardiovascular rehabilitation, the optimal training modality remains uncertain, particularly among patients with reduced and preserved ejection fraction.\n\nThis randomized controlled trial will evaluate the efficacy of a novel inspiratory muscle training protocol using tapered flow resistive loading (TFRL) compared with conventional threshold loading (TL) and usual care. A total of 108 clinically stable patients with heart failure (NYHA class II-III) will be enrolled. Participants will be stratified according to heart failure phenotype (reduced or preserved ejection fraction) and allocated to one of three groups: TFRL, TL, or control. Both training interventions will be performed for 8 weeks in combination with supervised exercise-based cardiac rehabilitation.\n\nPrimary and secondary outcomes will include inspiratory muscle strength and endurance, exercise capacity, pulmonary function, dyspnea, skeletal muscle oxygenation, autonomic balance, arterial stiffness, and health-related quality of life. The study is powered to detect moderate between-group differences and interaction effects with 80% statistical power and a two-sided alpha level of 0.05. Changes over time and between groups will be analyzed using analysis of covariance (ANCOVA), adjusting for baseline inspiratory muscle strength.\n\nThe trial aims to determine whether TFRL provides superior clinical and physiological benefits compared with conventional inspiratory muscle training and whether treatment responses differ according to heart failure phenotype.",[27],"Heart Failure",[27,29,30,31,32],"Inspiratory Muscle Training","Cardiac Rehabilitation","Tapered Flow Resistive Loading","Exercise Capacity","NOT_YET_RECRUITING","2026-06-22",{"date":36,"type":37},"2026-06-26","ACTUAL",{"date":39,"type":21},"2026-06",{"date":41,"type":21},"2028-07",{"name":43,"class":44},"Universidad Nacional Andres Bello","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":45},"100643384","contralateral-resistance-training-during-immobilization-in-patients-with-acromioclavicular-joint-injury-100643384","NCT07628361","Contralateral Resistance Training During Immobilization in Patients With Acromioclavicular Joint Injury","Effects of Contralateral Eccentric and Concentric Resistance Training During Immobilization on Neuromuscular Function, Functional Recovery, and Quality of Life in Patients With Acromioclavicular Joint Injury: A Randomized Controlled Trial","CROSS-ACD","Inclusion Criteria:\n\n* Men and women aged 18 to 36 years.\n* Diagnosis of acute acromioclavicular joint injury confirmed by an orthopedic surgeon.\n* Physician-prescribed upper-limb immobilization using a sling for approximately 2 to 4 weeks, with or without surgical repair.\n* Ability to understand study procedures and provide written informed consent.\n* Medical clearance to participate in the rehabilitation and resistance training program.\n\nExclusion Criteria:\n\n* Previous surgery or severe musculoskeletal injury affecting either upper limb within the previous 12 months.\n* Neurological disorders affecting motor function or neuromuscular performance.\n* Contraindications to transcranial magnetic stimulation according to established safety guidelines.\n* Current participation in another clinical trial or structured upper-limb rehabilitation program.\n* Cognitive impairment or inability to comply with study procedures.\n* Pregnancy.\n* Any medical condition that, in the opinion of the investigators, may compromise participant safety or study participation.","36 Years",{"count":56,"type":21},16,[24],"This randomized controlled trial aims to compare the effects of contralateral eccentric and concentric resistance training performed during the immobilization period following acromioclavicular joint injury. Immobilization is commonly prescribed after injury but may lead to reductions in muscle mass, neuromuscular function, force production, and upper-limb functionality.\n\nContralateral resistance training, also known as cross-education training, involves exercising the non-injured limb to induce beneficial adaptations in the immobilized limb through neural mechanisms. While both eccentric and concentric exercise may produce contralateral effects, their relative effectiveness in a clinical population remains unclear.\n\nParticipants with acute acromioclavicular joint injury requiring sling immobilization will be randomly assigned to either a contralateral eccentric training group or a contralateral concentric training group. During immobilization, participants will perform supervised resistance training with the non-injured upper limb. Following immobilization, all participants will receive the same standardized rehabilitation program.\n\nNeuromuscular function, muscle morphology, force production, upper-limb function, and quality of life will be assessed before immobilization, after immobilization, and following rehabilitation. The findings may contribute to the development of more effective rehabilitation strategies for patients recovering from upper-limb injuries requiring temporary immobilization.",[60,61],"Acromioclavicular Joint Injury","Acromioclavicular Joint Dislocation",[63,64,65,66,67,68,69,60,70,71,72,73,74,75,76],"Cross-Education","Contralateral Training","Eccentric Exercise","Concentric Exercise","Resistance Training","Immobilization","Shoulder Rehabilitation","Neuromuscular Function","Muscle Strength","Transcranial Magnetic Stimulation","Electromyography","Upper Limb Function","Physical Therapy","Rehabilitation","RECRUITING","2026-06-04",{"date":80,"type":37},"2026-06-08",{"date":82,"type":37},"2026-01-01",{"date":84,"type":21},"2027-07-01",{"name":43,"class":44},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":93,"minAge":17,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":113,"leadSponsor":115,"locationsCount":45},"100617790","exercise-and-neuromodulation-in-fibromyalgia-100617790","NCT07323199","Exercise and Neuromodulation in Fibromyalgia","High-Intensity Interval Training (HIIT) and Transcranial Direct Current Stimulation (tDCS) in Women With Fibromyalgia - Effects on Clinical and Neuro-physiological Variables: Randomized Clinical Trial Protocol","Inclusion Criteria:\n\n* Women with a diagnosis of Fibromyalgia by a physician according to the criteria of the American College of Rheumatology (ACR) 2016\n* A stable medical treatment for symptoms for at least 4 weeks before participation (stable doses of medication)\n* Reported pain equal to or higher than 40 mm on the visual analogue scale (moderate or severe pain) for more than 3 months\n* Body mass index (BMI) between 18.5 and 39.9 kg m-2,\n* Controlled high blood pressure.\n\nExclusion Criteria:\n\n* Isolated inflammatory joint, cancer, infectious, traumatic, localised neuropathic or degenerative joint pain.\n* Intense headache, cerebral surgery, seizure\u002Fepilepsy, cardiovascular, lung, metabolic (II diabetes mellitus), retinopathy or neurological diseases (i.e. stroke and traumatic brain injury antecedents),\n* Severe psychiatric disorders, major depression\n* Substance abuse.\n* Currently pregnant\u002Fbreastfeeding,\n* Under physical therapy treatment or have participated in a designed sports or exercise training in systematic programs in the last 3 months.\n* Unable to speak or read Spanish fluently (inability to understand the pain scale and cooperate in testing)","FEMALE","65 Years",{"count":96,"type":21},40,[24],"Exercise is recommended for people with fibromyalgia because it can reduce symptoms and improve quality of life. Some studies show that high-intensity exercises like running or cycling (also called high-intensity interval training, or HIIT) may reduce symptoms more effectively than slower, traditional exercises.\n\nThere are also new treatments, like non-invasive neuromodulation, which uses a gentle current to stimulate brain cells. This technique can help reduce pain in people with fibromyalgia. However, we don't yet know if combining HIIT and neuromodulation works better than exercise alone. We also want to find out if this combination helps improve other symptoms like fatigue and poor sleep.\n\nThe goal of this study is to see how a combination of HIIT and neuromodulation affects pain, fatigue, sleep, and muscle strength in women with fibromyalgia.\n\nThe investigators are asking two main questions:\n\nDoes combining HIIT and neuromodulation reduce pain better than exercise alone? Does this combination improve how the brain controls pain, muscles, and other symptoms like fatigue and sleep problems? What Will the Study Involve?\n\nThree different exercise training programs will be compared:\n\nHIIT with neuromodulation (tDCS): The participant will do HIIT by cycling at a high intensity for 1 minute, then resting for 2 minutes. Then, this will be repeated 10 times. At the same time, the researchers will place two small, damp sponges on the head of the participant. These sponges connect to the tDCS device, which sends a gentle current to your brain. It might feel a tingling sensation at first, but it will fade away.\n\nHIIT with a \"sham\" (inactive) neuromodulation: This is similar to the first program, but the tDCS device will only be active for a few minutes at the beginning and end of the session.\n\nHIIT alone: This involves just the cycling exercise with no brain stimulation. Who Can Participate?\n\nThe researchers are looking for women who:\n\nAre 18-65 years old and have been diagnosed with fibromyalgia Experience moderate to high levels of pain Have stable blood pressure (if they have hypertension) Are not regularly active (don't do more than 30 minutes of exercise at least 3 times per week)\n\nWhat Will the Study involve?\n\nThe participant will:\n\nAttend 6 conditioning sessions (cycling) over two weeks to prepare their body. Complete 4 weeks of HIIT training, three times per week, at Universidad Andres Bello.\n\nAttend 3 assessment sessions in our lab: before the conditioning, before the training, and after the training. These will include:\n\nNon-invasive tests to measure your physical fitness, muscle strength, and pain sensitivity Brain and muscle connection tests. Questionnaires about your sleep, pain, fatigue, anxiety, depression, and exercise enjoyment\n\nWhat the participant will get?\n\nAt the end of the study in addition to the training benefits, participants will receive a detailed report showing their body composition (muscle and fat levels) before and after the training.",[100],"Fibromyalgia (FM)",[102,103,104,105,106,107,108],"Fibromyalgia","central sensitization","Pain","intracortical excitability","HIIT - HIGH-INTENSITY INTERVAL TRAINING","tDCS - transcranial direct stimulation","transcranial magnetic stimulation","2025-12-26",{"date":111,"type":37},"2026-01-07",{"date":82,"type":21},{"date":114,"type":21},"2027-06",{"name":43,"class":44},{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":132,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":45},"100571995","effects-of-hiit-and-concurrent-hittplyometric-training-on-muscle-tendon-structure-function-and-metabolism-in-pediatric-population-with-obesity-at-different-biological-maturation-states-hiit-pro-kids-100571995","NCT06727500","Effects of HIIT and Concurrent HITT\u002FPlyometric Training on Muscle-tendon Structure, Function and Metabolism in Pediatric Population With Obesity at Different Biological Maturation States (HIIT-PRO Kids).","Effects of HIIT and Concurrent HITT\u002FPlyometric Training on Muscle-tendon Structure, Function and Metabolism in Pediatric Population With Obesity at Different Biological Maturation States (HIIT-PRO Kids): A Study Protocol of Randomized Controlled Trial","HIIT-PRO-kids","Inclusion Criteria:\n\n* Pediatric population with obesity determined by the body mass index by z-score (BMI-z) ≥ 2 standard deviations (SD) and ≤ 3.5 SD of the median for age and sex.\n* Pediatric population with -1 to -3 APHV (pre-APHV) and +1 to +3 APHV (post-APHV).\n\nExclusion Criteria:\n\n* Cognitive Disabilities.\n* Musculoskeletal condition that prevents regular physical activity.\n* Severe heart diseases that contraindicate the practice of physical activity.\n* Individuals who perform supervised exercise in the past six months.","7 Years","17 Years",{"count":96,"type":21},[24],"The randomized controlled trial will compare the effects of a High-intensity interval training (HIIT) protocol versus a HIIT plus plyometric training in the muscle-tendon structure function and metabolism of the pediatric population with obesity at different biological maturational stages (pre-to-age peak velocity \\[APHV\\] and post-APHV). Both groups perform baseline evaluations of the main and secondary outcomes and receive the intervention for twelve weeks, three times per week. Once the interventions are completed, the participants undergo the same evaluations they performed at baseline.",[130,131],"Pediatric Obesity","Training Effectiveness",[133,134,135,136,137],"Pediatric obesity","High-intensity interval training","Tendon mechanical properties","Plyometric training","Biological maturation stages","2025-08-28",{"date":140,"type":37},"2025-09-05",{"date":142,"type":37},"2025-04-01",{"date":144,"type":21},"2026-09-01",{"name":43,"class":44},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":154,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":162,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":45},"100571872","pediatric-neurogenetic-diagnosis-support-platform-100571872","NCT06725901","Pediatric Neurogenetic Diagnosis Support Platform","Diagnostic Support Platform for the Identification of Pediatric Genetic Neurological Diseases Through a Machine Learning-Based Recommendation System","DIAGEN-IA","Inclusion Criteria:\n\n* Neuropediatricians working in the Carlos Van Buren Hospital.\n* Participants providing care to pediatric patients (under 18 years of age).\n* Native Spanish speakers or those with certified C1-level Spanish proficiency according to the Common European Framework of Reference for Languages.\n* Professionals responsible for referring pediatric patients with suspected rare diseases to a clinical geneticist.\n\nExclusion Criteria:\n\n* Refusal to participate.",true,{"count":156,"type":21},9,[24],"This study evaluates a diagnostic support platform, DIAGEN-IA, designed to identify pediatric neurological diseases with a genetic basis. Conducted at Carlos Van Buren Hospital in Chile, it aims to determine if the platform reduces inappropriate referrals to clinical geneticists, improves diagnostic evaluations, enhances referral quality, and increases user satisfaction. A prospective before-and-after design will compare outcomes across two phases: baseline data collection and an intervention phase using DIAGEN-IA. Healthcare professionals will use the platform to guide referrals and diagnostic studies. Outcomes include referral appropriateness, completeness of evaluations, quality of referrals, and user satisfaction.",[160,161],"Genetic Disease","Neurogenetic Disorders",[163,164,165,166,167,168],"Neurogenetic disorders","Genetic disease","Pediatrics","Clinical Decision Support Systems","Referral and Consultation","Bayesian Network","2025-05-22",{"date":171,"type":37},"2025-05-29",{"date":173,"type":37},"2024-12-10",{"date":175,"type":21},"2025-12-30",{"name":43,"class":44},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":16,"minAge":185,"maxAge":17,"enrollmentInfo":186,"targetDuration":4,"studyType":22,"phases":188,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":45},"100548979","functional-and-neuroplastic-effects-of-habit-ile-in-children-with-bilateral-cerebral-palsy-100548979","NCT06428032","Functional and Neuroplastic Effects of HABIT-ILE in Children With Bilateral Cerebral Palsy","Functional and Neuroplastic Effects of Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) in Children With Bilateral Cerebral Palsy: a Randomized Controlled Trial","FuN HABIT-ILE","Inclusion Criteria:\n\n* Children with medical diagnosis of bilateral cerebral palsy\n* Cognitive capacity and language that allows understanding and following the therapist's instructions.\n* Manual Ability Classification System (MACS) levels I to III\n* Bimanual Fine Motor Function (BFMF) levels I to III\n* Gross Motor Function Classification System (GMFCS) levels I to III\n\nExclusion Criteria:\n\n* Severe visual problems\n* Movement restriction due to orthopedic surgery in less than a year\n* Treatment with botulinum toxin and\u002For baclofen pump in the last 6 months\n* Contraindications to receive transcranial magnetic stimulation (epileptic history, metallic implants, neoplasm, etc.)","8 Years",{"count":187,"type":21},48,[24],"This randomized controlled trial will compare the effects of neuroplastic and functional changes of Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) when presented in two periods (2HG; n=24) versus a single period (1HG; n=24) in people with bilateral CP. The 1HG will receive 65 hours of HABIT-ILE over one intervention period; the 2HG will receive 130 hours over two intervention periods, within 6 months apart. Children will be assessed at 6 time points: baseline, three weeks after the start, at 3, 6, 7 and 9 months after the start of the study.",[191],"Cerebral Palsy",[193,194,195,196],"HABIT-ILE","Intensive motor therapy","Motor skill learning","Children","2024-07-09",{"date":199,"type":37},"2024-07-11",{"date":201,"type":37},"2024-06-03",{"date":203,"type":21},"2027-12-31",{"name":43,"class":44},""]