[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad Rey Juan Carlos\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":411},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,46,78,102,132,154,182,206,233,259,290,317,340,355,384],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100053696","menstrual-cycle-symptoms-and-female-health-100053696",false,"NCT07699224","Menstrual Cycle Symptoms and Female Health","Prevalence of Subclinical Ovulatory Disturbances and Symptoms During the Menstrual Cycle and Their Relationship With Physical and Mental Health in Spanish Women of Reproductive Age (Prevalencia de Alteraciones Ovulatorias subclínicas y síntomas Durante el CICLO Menstrual y su relación Con la Salud física y Mental en Mujeres españolas en Edad Reproductiva).","CICLOS","Inclusion Criteria:\n\n* Females\n* Between 18 and 45 years\n* Naturally menstruating.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding.\n* Hormonal contraceptive methods during the 6 months before the study.\n* hysterectomy or ooforectomy.\n* Smoking.","FEMALE","18 Years","45 Years",{"count":21,"type":22},400,"ESTIMATED","5 Months","OBSERVATIONAL","The complexity inherent to the hormonal fluctuations associated with the female menstrual cycle (MC) has contributed, from a methodological perspective in research, to the neglect of women's physiological characteristics and to the silencing and normalization of symptoms linked to different life stages and hormonal environments. The scarce and outdated available data suggest high percentages of women experiencing perimenstrual symptoms, such as premenstrual syndrome or menstrual pain, as well as intermenstrual discomfort. These symptoms not only significantly impair daily activities but, due to their normalization, often lead to the underdiagnosis of other gynecological conditions.\n\nSubclinical ovulatory disturbances-characterized by the suppression of ovarian hormones as an adaptive defense mechanism against various environmental stressors-are also frequently underdiagnosed. These disturbances typically do not affect MC length, making them difficult to detect, and although the process is reversible, it may initiate irreversible consequences for certain tissues, such as bone mass loss. However, neither women nor their educational, occupational, or healthcare environments appear to have the resources and\u002For knowledge required to adequately address these issues.\n\nAll of this may compromise women's rights to adequate sexual and reproductive health and to a dignified quality of life, as recognized under the second line of Axis 4, \"Effective Rights for All Women,\" of the Strategic Plan for Effective Equality between Women and Men 2022-2025. Therefore, the aims of this multicenter project-carried out by a multidisciplinary research team from seven Spanish universities and three international institutions-are to describe the prevalence of symptoms and alterations related to the MC in women of reproductive age and to identify their associations with physical and mental health.\n\nTo accomplish this, an observational study will be conducted in a large sample of women of reproductive age, including multiple symptom and perceived-health questionnaires and ovulation monitoring. In addition, in a subsample of participants, bone mineral density will be assessed, blood levels of sex hormones will be monitored, and an innovative analysis of health biomarkers (glycemic and lipid profile, and inflammation) from menstrual blood will be included. This will be complemented by a qualitative study of experiences related to MC-associated symptoms and alterations, using in-depth interviews and thematic content analysis.\n\nThe findings of this project are expected to support various dissemination and educational actions, justify the design of more inclusive educational and healthcare policies, and enhance the understanding of women's needs, ultimately contributing to improved symptom management and quality of life.",[27,28,29,30,31,32],"Menstrual Cycle","Menstrual Distress (Dysmenorrhea)","Premenstrual Syndrome","Abnormal Uterine Bleeding (AUB)","Ovulation Disorder","Perceived Health Status","RECRUITING","2026-07-08",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":37},"2026-01-21",{"date":41,"type":22},"2026-12",{"name":43,"class":44},"Universidad Rey Juan Carlos","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":45},"100638187","feasibility-of-a-community-based-multimodal-exercise-programme-in-parkinsons-disease-100638187","NCT07618728","Feasibility of a Community-Based Multimodal Exercise Programme in Parkinson's Disease","Feasibility and Preliminary Effectiveness of an Individualised Multimodal Group-Based Exercise Programme for People With Parkinson's Disease: A Non-Randomized Feasibility Study","Eligibility Criteria The eligibility criteria will be identical for both the experimental and control groups. However, this study will employ a sequential recruitment design. Participants for the control group will be recruited following the experimental group and will be matched (1:1 ratio) based on sex, age (± 5 years), and disease severity according to the Hoehn \\& Yahr (H\\&Y) scale.\n\nInclusion Criteria:\n\n* Subjects diagnosed with Idiopathic Parkinson's Disease according to the UK Parkinson's Disease Society Brain Bank Diagnostic Criteria.\n* Subjects staged between 1 and 3 on the Hoehn \\& Yahr Scale. For matching purposes, stage 1 includes stage 1.5, and stage 2 includes stage 2.5.\n\nExclusion Criteria:\n\n* Subjects diagnosed with a neurological disease other than PD.\n* Those diagnosed with a cardiovascular, respiratory, or metabolic disease or other conditions that represent a contraindication to physical exercise.\n* Those who have suffered an exacerbation or hospitalization in the last three months prior to starting the assessment protocol or during the therapeutic intervention process.\n* Those who have received a course of steroids, intravenously or orally, six months prior to the start of the study or during the therapeutic intervention process.\n* Those with cognitive impairment (defined as a score \\\u003C 21 on the Montreal Cognitive Assessment, MoCA) or language impairments that prevent adequate communication, comprehension, or following of exercise instructions.\n* Participation in a structured, individualized strength and\u002For aerobic exercise program within the three months prior to enrollment.","ALL",{"count":55,"type":22},64,"INTERVENTIONAL",[58],"NA","This study aims to evaluate the feasibility and preliminary effectiveness of a multimodal, group-based but individualised therapeutic exercise programme for people with Parkinson's disease delivered within a real-world community-based patient association setting.\n\nThe primary objective is to assess the feasibility of implementing the programme, including recruitment, consent, adherence, intervention completion, acceptability, perceived exertion and safety. Secondary objectives are to obtain preliminary comparative information regarding the effects of the intervention on motor and non-motor symptoms, physical fitness, pain-related outcomes and exercise-induced hypoalgesia.\n\nThis is a non-randomized sequential feasibility study including an intervention group participating in a 12-week multimodal exercise programme and a matched non-exercise control group maintaining usual activities. Outcomes will be assessed at baseline, post-intervention and 6-month follow-up.",[61],"PARKINSON DISEASE (Disorder)",[63,64,65,66,67,68,69],"Parkinson's Disease","Exercise programme","Feasibility","Multimodal","Individualised","Motor symptoms","Non-motor symptoms","2026-06-01",{"date":72,"type":37},"2026-06-03",{"date":74,"type":37},"2025-09-08",{"date":76,"type":22},"2027-09",{"name":43,"class":44},{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":56,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":4},"100638193","warm-up-of-the-inspiratory-musculature-and-its-impact-in-swimming-performance-100638193","NCT07595328","Warm-up of the Inspiratory Musculature and Its Impact in Swimming Performance","Warm-up of the Inspiratory Musculature and Its Impact on Physiological Parameters and Swimming Performance: Exploration of Intensities Based on Maximal Inspiratory Pressure","Inclusion criteria:\n\n* Participants of both sexes, aged over 18 years.\n* Minimum swimming training frequency of at least two sessions per week, with a minimum duration of 30 minutes per session, consistently maintained over the last three months.\n\nExclusion criteria:\n\n* Current or previous diagnosis of respiratory diseases.\n* Musculoskeletal injuries limiting the ability to perform a 100-meter swimming test.\n* Participation in inspiratory muscle training programs within the last six months.",true,{"count":87,"type":22},52,[58],"Objective To evaluate the acute effect of four inspiratory warm-up intensities (15%, 40%, 60%, and 80% of maximal inspiratory pressure \\[MIP\\]) on 100 m freestyle performance, and to analyze their impact on heart rate, blood lactate concentration, perceived exertion, and dyspnea in trained swimmers.\n\nMethods A randomized, crossover, double-blind experimental study was conducted. Participants were swimmers aged ≥18 years, with no respiratory or musculoskeletal pathology.\n\nEach participant completed, in sessions separated by at least three days, an inspiratory muscle warm-up consisting of 30 breaths against resistive loads set at 15%, 40%, 60%, and 80% of their MIP, previously determined using standardized procedures.\n\nFollowing each intervention, participants performed a maximal 100 m freestyle test. The following variables were recorded:\n\nSwimming time Heart rate (during and post-exercise) Post-exercise capillary blood lactate concentration Rating of perceived exertion (Borg scale) Dyspnea (Dyspnea-12)\n\nConclusions This study will help identify the optimal inspiratory warm-up intensity to enhance swimming performance.",[91,92],"Swimming","IMT","NOT_YET_RECRUITING","2026-05-12",{"date":96,"type":37},"2026-05-19",{"date":98,"type":22},"2026-09",{"date":100,"type":22},"2027-01",{"name":43,"class":44},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":56,"phases":112,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":45},"100590535","mixed-reality-for-upper-limb-rehabilitation-in-people-with-multiple-sclerosis-virtualdomus-100590535","NCT06968676","Mixed Reality for Upper Limb Rehabilitation in People With Multiple Sclerosis (VIRTUALDOMUS)","Effects of Mixed Reality on Manipulative Skills, Functionality and Quality of Life in People With Multiple Sclerosis. A Randomized Controlled Trial (VIRTUAL-DOMUS)","VIRTUALDOMUS","Inclusion Criteria:\n\n-\\>18 years of age.\n\n* Diagnosis of MS according to McDonald criteria (53) with a time of evolution longer than two years.\n* Assessment on the Kurtzke Multiple Sclerosis Disability Status Scale (EDSS) with a score between 2. 0 (minimal disability in one section of the FS (at least one with a score of 2).) to 7.0 (unable to walk more than a few steps, even with assistance, basically confined to wheelchair and able to transfer from wheelchair to another place, or can manage to go to the toilet for 12 hours a day) .\n* Stable medical treatment for at least six months prior to surgery.\n* Upper extremity muscle tone no greater than 2 points (moderate hypertonia, increased muscle tone during most of the arc of motion, but can passively move the affected part with ease) on the modified Ashworth Scale.\n* Muscle balance equal to or greater than 3 in the upper extremity.\n* Score less than or equal to 4 points on the \"Pyramidal Function\" section of the EDSS functional scale.\n* Absence of cognitive impairment, with ability to understand instructions and score equal to or greater than 24 on the Minimental Test.\n\nA- score equal to or less than 2 points on the \"Mental Functions\" section of the EDSS.\n\nExclusion Criteria:\n\n* Diagnosis of a neurological disease or musculoskeletal disorder other than MS.\n* Diagnosis of a cardiovascular, respiratory or metabolic disease or other conditions that may interfere with this study.\n* Having suffered an exacerbation or hospitalization in the last 3 months before starting the assessment protocol, or during the therapeutic intervention process.\n* Having received a course of steroids, intravenous or oral, 6 months prior to the start of the assessment protocol and within the intervention period of the study duration.\n* Having received treatment with botulinum toxin in the 6 months prior to the start of the study.\n* A score higher than 2 points on the modified Ashworth scale.\n* Cognitive or language impairment that prevents adequate communication or comprehension.\n* The presence of visual disturbances not corrected by ocular devices; or a history of photosensitive epilepsy.",{"count":111,"type":22},30,[58],"Although virtual reality has attracted the attention of health professionals and neurorehabilitation field, research about mixed reality (MR) in people with neurological disorders, particularly multiple sclerosis (MS), is very limited. Furthermore, to our knowledge, studies about the effects of MR in upper limb (muscle strength and fatigability, coordination and dexterity, functionality and quality of life) in people with MS are nonexistent.\n\nThe main objective of our study are:\n\nTo know the clinical effects of mixed reality environments and re-training activities linked to their spaces (kitchen, bathroom, living room, bedroom and terrace-garden), designed for the treatment of upper limb impairments in people with MS, in combination with a conventional physiotherapy program, on manipulative skills, functionality and quality of life in people with MS.\n\nThe secundary objectives are:\n\nTo study the clinical effects on range of motion, muscle strength, coordination and manual dexterity, fatigue, functionality and quality of life in people with MS.\n\nTo analyze satisfaction and adherence to treatment, the occurrence of adverse effects and the level of workload perceived by participants.\n\nA double-blind randomized controlled trial is proposed. The sample will be randomly divided into two groups: the experimental group will receive treatment based on mixed reality for MMSS, designed by the research team and using Meta Quest 3.0 glasses, in combination with conventional physiotherapy; and the control group will receive the same conventional therapy. Both groups will receive 2 sessions\u002Fweek, 60min\u002Fsession, for 10 weeks. The mixed reality environments to be designed will be a kitchen, a bathroom, a living room, a bedroom and a terrace-garden, with the tasks to be performed in each location. The pre, post-treatment and one-month follow-up outcome measures will be: range of motion, manual grip strength, manual dexterity, fatigue, functionality, quality of life, satisfaction with the technology, adherence, adverse effects and perceived workload. A statistical comparison study will be carried out establishing as an inter-subject factor the group parameter and as intra-subject factors each of the measurements and the treated side.",[115],"Multiple Sclerosis",[117,118,119,120,121,122,123],"Multiple sclerosis","Mixed reality","Upper limb","Rehabilitation","Manipulative skills","Functionality","Quality of life","2026-04-28",{"date":126,"type":37},"2026-05-05",{"date":128,"type":37},"2025-09-01",{"date":130,"type":22},"2027-12-31",{"name":43,"class":44},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":56,"phases":142,"briefSummary":143,"conditions":144,"keywords":145,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":45},"100577202","blood-flow-restriction-for-upper-limb-rehabilitation-in-people-with-multiple-sclerosis-a-randomized-controlled-trial-bfrt-em-100577202","NCT06795230","Blood Flow Restriction for Upper Limb Rehabilitation in People With Multiple Sclerosis. A Randomized Controlled Trial (BFRT-EM)","Effects of a Low-intensity Muscle Strengthening Protocol in Combination With Blood Flow Restriction Training on Upper Limb Impairment in People With Multiple Sclerosis. A Randomized Controlled Trial","BFRT-EM","Inclusion Criteria:\n\n* \\>18 years of age.\n* Diagnosis of MS according to McDonald criteria (53) with a time of evolution longer than two years.\n* Assessment on the Kurtzke Multiple Sclerosis Disability Status Scale (EDSS) with a score between 2. 0 (minimal disability in one section of the FS (at least one with a score of 2).) to 7.0 (unable to walk more than a few steps, even with assistance, basically confined to wheelchair and able to transfer from wheelchair to another place, or can manage to go to the toilet for 12 hours a day) .\n* Stable medical treatment for at least six months prior to surgery.\n* Upper extremity muscle tone no greater than 2 points (moderate hypertonia, increased muscle tone during most of the arc of motion, but can passively move the affected part with ease) on the modified Ashworth Scale.\n* Muscle balance equal to or greater than 3 in the upper extremity.\n* Score less than or equal to 4 points on the \"Pyramidal Function\" section of the EDSS functional scale.\n* Absence of cognitive impairment, with ability to understand instructions and score equal to or greater than 24 on the Minimental Test.\n* A score equal to or less than 2 points on the \"Mental Functions\" section of the EDSS.\n\nExclusion Criteria:\n\n* Diagnosis of a neurological disease or musculoskeletal disorder other than MS.\n* Diagnosis of a cardiovascular, respiratory or metabolic disease or other conditions that may interfere with this study.\n* Having suffered an exacerbation or hospitalization in the last 3 months before starting the assessment protocol, or during the therapeutic intervention process.\n* Having received a course of steroids, intravenous or oral, 6 months prior to the start of the assessment protocol and within the intervention period of the study duration.\n* Having received treatment with botulinum toxin in the 6 months prior to the start of the study.\n* A score higher than 2 points on the modified Ashworth scale.\n* Cognitive or language impairment that prevents adequate communication or comprehension.\n* Medical complications such as: history of deep vein thrombosis, pulmonary embolism, vascular disease, thrombophilia, or any circulatory or coagulation disorder.",{"count":141,"type":22},20,[58],"Although the Blood Flow Restriction Training (BFRT) system has attracted the attention of health professionals, research on this tool in people with neurological pathology, particularly multiple sclerosis (MS), is very limited. Furthermore, to our knowledge, studies on the effect of the BFRT system on forearm-hand muscle strength and fatigability, coordination and dexterity, functionality and quality of life in people with MS are nonexistent.\n\nThe main objective of our study are:\n\n-To know the effects of low intensity training in combination with the BFRT system on upper limb strength and forearm and hand fatigability, dexterity, functionality and quality of life in people with MS.\n\nSecondary Objectives\n\n* To know if a low-intensity muscle strengthening program in combination with the BFRT system is superior to a conventional strengthening program.\n* To know the adherence and satisfaction with the experimental intervention.\n\nThe investigators propose to conduct a randomized controlled trial (RCT) with examiner blinding with pre-intervention, post-intervention and follow-up assessment, following the recommendations of the CONSORT guidelines, designed to study the effects of the application of a low-intensity muscle strengthening program in combination with the BFRT system. This intervention will be carried out at the Leganés Multiple Sclerosis Association (ALEM). Patients will be randomly assigned through the GraphPad Software® QuickCalcs application to 2 study groups. A control group, which will receive a low intensity strengthening program in combination with the BFRT system; and an experimental group, which will receive a high intensity strengthening program.\n\nVoluntary participation will be requested from patients diagnosed with MS in the Leganés Multiple Sclerosis Association (ALEM) who meet the inclusion criteria. Acceptance of the study and signature of the informed consent form will be required prior to the start of the program.\n\nAs this is the first study to evaluate the effectiveness and feasibility of a low-intensity muscle strengthening protocol in combination with BFRT on forearm and hand muscle strength and fatigability, coordination, dexterity, functionality and quality of life in people with MS, the sample size will be determined based on the most similar scientific literature possible. Hill et al developed an investigation comparing the adaptations of MS patients to two types of intervention: high intensity or conventional strengthening program versus low intensity in combination with BFRT. Since this is the only investigation to date that includes MMSS exercises in their intervention, we consider that the sample size proposed by Hill et al is the most appropriate for our investigation. The sample size obtained in that investigation was 19 subjects, so for the sample size of the present investigation a total of 19 subjects is proposed. However, estimating a 10% possible percentage of losses, we estimate a total of 21 total participants to be recruited.\n\nPatients will be randomly assigned via the GraphPad Software® QuickCalcs application to 2 study groups. A control group, which will receive a low-intensity strengthening program in combination with the BFRT system; and an experimental group, which will receive a high-intensity strengthening program.",[115],[117,119,120,146],"Blood Flow Restriction Training",{"date":148,"type":37},"2026-04-29",{"date":150,"type":37},"2025-03-01",{"date":152,"type":22},"2026-12-31",{"name":43,"class":44},{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":85,"sex":53,"minAge":4,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":56,"phases":164,"briefSummary":165,"conditions":166,"keywords":168,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":45},"100633262","effects-of-physical-exercise-combined-with-transcranial-direct-current-stimulation-in-parkinsons-disease-100633262","NCT07524400","Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease","Effects of the Combination of Physical Exercise and Transcranial Direct Current Stimulation on Motor Function and Underlying Neurophysiological Mechanisms in Parkinson's Disease","ExtDCSPARK","Inclusion Criteria:\n\nClinical diagnosis of idiopathic Parkinson's disease, established according to the UK Parkinson's Disease Society Brain Bank Criteria.\n\nAbility to understand and comply with study procedures.\n\nStable antiparkinsonian medication regimen prior to study participation.\n\nExclusion Criteria:\n\nSignificant cognitive impairment, defined as a score \\\u003C 23 on the Mini-Mental State Examination (MMSE).\n\nBelow-average premorbid intelligence, defined as a score \\\u003C 40 on the Vocabulary subtest of the Wechsler Adult Intelligence Scale - Third Edition (WAIS-III).\n\nClinically significant depression, defined as a score \\> 10 on the Geriatric Depression Scale (GDS-15).\n\nCurrent treatment with cholinesterase inhibitors.\n\nPresence of severe cardiovascular disease, including but not limited to:\n\nCongestive heart failure\n\nIschemic heart disease\n\nCardiac pacemaker\n\nOrthostatic hypotension\n\nUncontrolled diabetes mellitus.\n\nHistory of stroke or traumatic brain injury.\n\nHistory of seizure disorder or epilepsy.\n\nPresence or prior implantation of a deep brain stimulation (DBS) device.\n\nHistory of major orthopedic surgery that could interfere with motor performance or gait.\n\nPresence of implanted electronic devices, including cardiac pacemakers, incompatible with study procedures.",{"count":163,"type":22},100,[58],"A controlled, blinded, and randomized clinical study will be carried out in a large sample of people with Parkinson's disease, where the combined effects of physical exercise and transcranial direct curren stimlation (tDCS) on motor function will be evaluated.",[167],"Parkinson' Disease",[169,170,171,172,173],"exercises training","transcranial direct electrical stimulation","cue training","cortical excitability","Transcranial Magnetic Stimulation","2026-04-06",{"date":176,"type":37},"2026-04-13",{"date":178,"type":22},"2026-05-10",{"date":180,"type":22},"2026-08-30",{"name":43,"class":44},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":190,"enrollmentInfo":191,"targetDuration":4,"studyType":56,"phases":192,"briefSummary":193,"conditions":194,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":205,"locationsCount":4},"100616956","whole-body-electrostimulation-for-functional-recovery-in-post-covid-syndrome-100616956","NCT07312357","Whole-Body Electrostimulation for Functional Recovery in Post-COVID Syndrome","Electrostimulation Suit as a Therapeutic Tool in Post-COVID Syndrome: Effects on Physical and Functional Status. A Randomized Controlled Trial","WB-EMS PostCOV","Inclusion Criteria:Adults aged 18 years or older.\n\nDiagnosis of post-COVID syndrome (long COVID), with persistent symptoms following SARS-CoV-2 infection.\n\nPresence of fatigue and\u002For functional limitations associated with post-COVID syndrome.\n\nAbility to understand the study procedures and provide written informed consent.\n\nAbility to participate in the intervention and assessments according to the study protocol.\n\n\\-\n\nExclusion Criteria:\n\nParticipation in other structured physical exercise or rehabilitation programs during the study period.\n\nPresence of severe cardiovascular disease or uncontrolled medical conditions that contraindicate physical activity or electrostimulation.\n\nNeurological disorders or severe neuromuscular diseases.\n\nUse of anabolic drugs or medications that may interfere with muscle function.\n\nPregnancy.\n\nEpilepsy.\n\nActive skin lesions or dermatological conditions in areas where electrodes are applied.\n\nRecent oncological surgery.\n\nAcute venous thrombosis.\n\nPresence of cardiac pacemakers or implanted electronic or conductive medical devices.\n\nAny clinical deterioration or condition that, in the opinion of the investigators, would make participation unsafe.\n\n\\-","70 Years",{"count":111,"type":22},[58],"Post-COVID syndrome is a condition that affects some people after recovering from the acute phase of COVID-19. Common symptoms include persistent fatigue, reduced physical capacity, and difficulties performing everyday activities, which can significantly impact quality of life and independence. At present, there is limited scientific evidence on effective rehabilitation strategies for this population.\n\nThe purpose of this study is to evaluate whether the use of a whole-body electrostimulation suit can improve fatigue, physical performance, and functional independence in people with post-COVID syndrome. Whole-body electrostimulation is a non-pharmacological technique that uses low-frequency electrical impulses to activate multiple muscle groups simultaneously and has shown potential benefits in other clinical populations.\n\nThis is a randomized, double-blind, controlled pilot clinical trial. Participants will be randomly assigned to either an experimental group, which will receive active whole-body electrostimulation during functional activities, or a control group, which will follow the same sessions using the electrostimulation suit with minimal stimulation (placebo condition). Neither participants nor outcome assessors will know which group each participant belongs to.\n\nThe intervention will consist of 12 supervised sessions conducted once per week. Outcomes will be assessed before and after the intervention, with an additional follow-up assessment three months later. The main outcomes include fatigue levels, functional capacity, physical performance, and independence in activities of daily living. Safety and tolerance to the intervention will be monitored throughout the study.\n\nThe results of this study may help to determine the feasibility and potential effectiveness of whole-body electrostimulation as a rehabilitation tool for people with post-COVID syndrome and provide preliminary data for future larger-scale clinical trials.",[195,196,197,198],"Post COVID Syndrome Long Covid","Post COVID Syndrome","Long COVID Fatigue","Long Covid","2025-12-16",{"date":201,"type":37},"2025-12-31",{"date":203,"type":22},"2026-03",{"date":41,"type":22},{"name":43,"class":44},{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":56,"phases":214,"briefSummary":215,"conditions":216,"keywords":220,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":45},"100602785","moderate-intensity-exercise-and-pain-sensitization-in-breast-cancer-survivors-a-case-based-study-100602785","NCT07128030","Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study","Inclusion Criteria:\n\n* Adult women diagnosed with stage I-III breast cancer\n* Completion of active treatment (surgery, chemotherapy, and\u002For radiotherapy) at least 6 months prior to enrollment\n* Presence of persistent pain or altered sensation in the upper quadrant of the affected limb related to oncologic treatment\n\nExclusion Criteria:\n\n* Bilateral breast cancer\n* Locoregional recurrence\n* Other malignancies\n* Pre-existing pain not related to cancer treatment\n* Neurological or cognitive disorders\n* Non-Spanish speakers\n* Contraindications to moderate-intensity physical activity",{"count":213,"type":22},10,[58],"The aim of this study was to evaluate the feasibility, safety, and acceptability of a supervised, combined moderate-intensity aerobic and resistance training program designed to reduce pain sensitization in BCS with persistent pain. Secondary objectives included assessing changes in pain intensity, somatosensory sensitivity, and temporal summation, while tertiary objectives focused on improvements in quality of life and functional capacity.",[217,218,219],"Exercise Training","Breast Cancer","Pain Management",[221,222,223,224],"pain severity","pain sensibilization","quantitative sensory testing","physical activity","2025-11-19",{"date":227,"type":37},"2025-11-24",{"date":229,"type":37},"2025-08-23",{"date":231,"type":22},"2026-02-23",{"name":43,"class":44},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":85,"sex":53,"minAge":4,"maxAge":4,"enrollmentInfo":240,"targetDuration":242,"studyType":24,"phases":4,"briefSummary":243,"conditions":244,"keywords":248,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":4},"100612296","understanding-the-lived-experience-and-bereavement-of-caregivers-of-people-with-alzheimers-disease-100612296","NCT07251738","Understanding the Lived Experience and Bereavement of Caregivers of People With Alzheimer's Disease","ALCARE","Inclusion Criteria:\n\n* Inclusion criteria for Group 1: relatives of people diagnosed with AD by a neurologist or geriatrician, who have suffered the loss of a relative with AD; who have lived with and\u002For cared for the person with AD until the end of their life; who agree to participate voluntarily in the project and who have signed the informed consent form.\n* Inclusion criteria for Group 2: relatives of people diagnosed with AD by a neurologist or geriatrician; who live with and\u002For care for the person with AD; who attend the Day Centre and who agree to participate voluntarily in the project and have signed the informed consent form.\n* Inclusion criteria for Group 3: relatives of people diagnosed with AD by a neurologist or geriatrician; who have their relative institutionalised in a nursing home and who agree to participate voluntarily in the project and have signed the informed consent form.\n\nExclusion Criteria:\n\n* Those who have not lived with or cared for relatives with AD and who do not agree to participate in the study will be excluded from the project.",{"count":241,"type":22},66,"1 Day","The main objective of this study is to explore the lived experience of caregivers and family members of people with Alzheimer's disease (AD), from the beginning of caregiving through the bereavement process following the patient's death. Using a mixed-methods design, qualitative data will be collected through in-depth interviews and combined with quantitative data obtained from standardized scales. The results will aim to determine whether prolonged caregiving significantly affects the caregiver's or family member's personal, emotional, and occupational well-being, as well as whether it leads to a reorganization of activities of daily living (ADL), an increased perception of burden, and\u002For a decreased quality of life. The study will also examine the presence of positive adaptation experiences.",[245,246,247],"Alzheimer Disease (AD)","Occupational Therapy","Family Caregivers",[249,246,250],"Alzheimer's disease","occupational balance","2025-11-18",{"date":253,"type":37},"2025-11-26",{"date":255,"type":22},"2025-12-01",{"date":257,"type":22},"2026-07-31",{"name":43,"class":44},{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":263,"acronym":264,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":53,"minAge":266,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":56,"phases":268,"briefSummary":269,"conditions":270,"keywords":274,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":289},"100597606","effectiveness-of-immersive-virtual-reality-combined-with-occupational-therapy-in-reducing-fall-risk-and-frailty-among-older-adults-100597606","NCT07060677","Effectiveness of Immersive Virtual Reality Combined With Occupational Therapy in Reducing Fall Risk and Frailty Among Older Adults","VIRTO-FRAIL","Inclusion Criteria:\n\n* Individuals aged 65 years or older\n* Regularly attending rehabilitation treatment at the Bouco Madrid Ferraz Residence\n* Having the ability to walk with or without assistive devices\n* Presenting sufficient cognitive capacity to understand instructions (score ≥ 24 on the MMSE)\n* Agreeing to participate voluntarily\n* Signing the informed consent form.\n\nExclusion Criteria:\n\n* Having a diagnosis of a severe neurological disease (such as advanced Parkinson's disease or ALS, among others)\n* Having a history of epilepsy or seizures (due to potential adverse effects with VR)\n* Experiencing cardiovascular instability or having a medical contraindication for physical activity\n* Presenting vestibular disorders\n* Participating in other similar intervention programs during the same period\n* Being unable to use virtual reality glasses due to intolerance or dizziness\n* Not agreeing to participate voluntarily in the study and\u002For not signing the informed consent form.","65 Years",{"count":111,"type":22},[58],"Population aging is a growing global phenomenon that poses significant challenges to healthcare systems, particularly in preventing falls and managing frailty among older adults. Falls remain a leading cause of morbidity and mortality in this population, affecting approximately one-third of individuals over 65 each year. At the same time, frailty syndrome (FS)-a clinical condition marked by progressive decline in physical and cognitive function-significantly increases the risk of falls, disability, and dependency. Pre-frailty, an intermediate and reversible stage, offers a key opportunity for preventive interventions.\n\nScientific evidence supports the effectiveness of interdisciplinary approaches to address frailty and fall prevention. In this context, occupational therapy plays a central role by promoting functional autonomy through meaningful activities. However, traditional approaches may be limited in individuals with low motivation or mild cognitive impairment. Therefore, integrating innovative technologies such as immersive virtual reality (IVR) emerges as a promising therapeutic strategy.\n\nIVR enables users to interact with simulated three-dimensional environments, enhancing cognitive stimulation, motor training, and treatment adherence. Modern devices like the Meta Quest 3 headsets provide accessible, safe, and adaptable immersive experiences, with reported benefits in balance, gait, attention, and motivation. Nonetheless, no studies to date have specifically evaluated the effectiveness of this technology when combined with conventional occupational therapy to reduce fall risk and frailty in older adults.\n\nThis project proposes a pilot randomized controlled trial (RCT), lasting 5 months, using a single-blind, parallel-group design. It will be conducted at the Bouco Madrid Ferraz Residential Center (Madrid, Spain), following CONSORT 2010 methodological guidelines. The primary aim is to assess the efficacy of a combined intervention using IVR through Meta Quest 3 headsets and occupational therapy, compared to conventional occupational therapy alone, in reducing fall risk, improving frailty status, enhancing quality of life, and increasing rehabilitation motivation in older adults.\n\nThe sample will include 30 participants (15 per group), selected based on specific inclusion and exclusion criteria. Participants will be randomly assigned to a control group (CG), receiving standard occupational therapy, or to an experimental group (EG), receiving a combined intervention of occupational therapy and IVR using the Kinesix XR platform, which is designed to enhance balance.\n\nThe intervention will last 8 weeks, with two one-hour sessions per week. The experimental group will receive 30 minutes of occupational therapy and 30 minutes of IVR per session. Assessments will be conducted at baseline, post-intervention, and at a 3-month follow-up using validated scales to measure fall risk, balance, frailty level, quality of life, and satisfaction.\n\nData will be pseudonymized, statistically analyzed using SPSS, and managed in compliance with the European General Data Protection Regulation (EU 2016\u002F679). The small sample size reflects the exploratory nature of the study, aimed at assessing feasibility, safety, and preliminary outcomes prior to conducting a larger-scale trial.\n\nUltimately, this project aims to provide initial evidence on an innovative intervention for older adults by integrating digital tools with conventional therapeutic approaches. If proven effective, the VIRTO-FRAIL model could lay the groundwork for new strategies in geriatric rehabilitation and fall prevention.",[271,272,273],"Frailty Syndrome","Older Adults, Balance","Fall Prevention in Healthy Aging",[275,246,276,277,278,279,280],"Inmersive Virtual Reality","Frailty Sindrome","Fall Prevention","Older Adults","Pre-Frailty","Quality of Life","2025-07-10",{"date":283,"type":37},"2025-07-16",{"date":285,"type":22},"2025-09-15",{"date":287,"type":22},"2025-11",{"name":43,"class":44},2,{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":296,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":298,"conditions":299,"keywords":302,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":45},"100586689","effectiveness-of-pulpotomy-in-symptomatic-permanent-teeth-with-deep-caries-lesions-100586689","NCT06918639","Effectiveness of Pulpotomy in Symptomatic Permanent Teeth With Deep Caries Lesions","Inclusion Criteria:\n\n* Patients over 18 years of age.\n* Patients in good general health, ASA I or ASA II with no contraindications to contraindications to receive a TPV procedure under local anaesthesia.\n* Tooth with symptomatology of pulpitis, both reversible and irreversible, to be determined by history of spontaneous pain, exacerbation of pain with heat and cold confirmed by the cold test and radiating pain.\n* Tooth without signs of pulp necrosis and absence of sinus tract and abscess.\n* Tooth in occlusion with antagonist tooth and without discomfort on chewing.\n* Tooth that can be directly restored.\n* Tooth with pocket depth and mobility within normal limits.\n* Extent of the caries lesion greater than two thirds of the amelodentine distance or which tooth or the pulp has been exposed during caries removal.\n\nExclusion Criteria:\n\n* Patients with allergies or intolerance to any anaesthetic solution.\n* Pregnant patients or patients who suspect pregnancy due to the impossibility of complementary radiographic tests cannot be carried out.\n* Patients with systemic pathology that prevents the use of a vasoconstrictor or with a compromised immune system that may influence the response to treatment.\n* Tooth with an immature apex.\n* Tooth that is not restorable or not viable for preservation.\n* Tooth with negative response to thermal sensitivity test or electrical test.\n* Tooth in which haemostasis cannot be achieved after exposure of the pulp, or with a pulp, or with a haemostasis time exceeding 10 minutes, where there is no pulp bleeding or partial or complete tissue necrosis is observed.",{"count":297,"type":22},50,"Preservation of pulp tissue would allow it to continue to exert its defensive and physiological functions and more tooth tissue would be preserved, leading to less weakening of the tooth. In addition, root canal treatment is a more complex therapeutic process that requires the use of more instruments, more time and more visits. To date, most clinical studies that have evaluated the success of pulpotomy treatments have been conducted on teeth with immature apexes. More studies are needed to evaluate VPT success in the permanent dentition in the long term.\n\nIn accordance with the above, the main objective of the study will be to determine the success of partial or total pulpotomy treatment in permanent teeth (\\>18 adults) with a closed apex and symptoms compatible with irreversible pulpitis. At the same time, the association of factors related to the patient, the treated tooth and specific treatment factors with the success of pulpotomies will be determined. On the other hand, the patient, perception and satisfaction with the treatment received will be evaluated.\n\nAll treatments (pulpotomies and restorations) will be carried out by the principal investigator.\n\nAfter recording the preoperative data, clinical and radiographic examination, a diagnosis will be made according to the classification of Wolters and collaborators , which will also guide us in the choice of pulp treatment: PP o CP Partial pulpotomy or complete pulpotomy. The maximum pulp haemostasis time will be 10 minutes. In both treatments, in the same appointment, the definitive restoration of the tooth will be carried out.\n\nThe evaluations will be performed at one week, 3 , 6 and 12 months postoperatively. This evaluation shall be performed by an examiner who shall be different from the one performing the treatment.\n\nThe main outcome of the present study will be the determination of the success of the pulpotomies.\n\n\\- Is vital pulp therapy a highly successful treatment for teeth with irreversible pulpitis?.\n\nOutcome measure 1: Success rate of vital pulp therapy\n\n\\- Do patients feel satisfied with this conservative pulp treatment? Outcome measure 2: Patient´s satisfaction with vital pulp therapy",[300,301],"Irreversible Pulpitis","Pulpotomy of Permanent Molars",[303,304,305,306,307,308],"pulpotomy","vitalpulptherapy","partialpulpotomy","biodentinexp","fullpulpotomy","completepulpotomy","2025-04-06",{"date":311,"type":37},"2025-04-09",{"date":313,"type":37},"2024-04-11",{"date":315,"type":22},"2027-01-01",{"name":43,"class":44},{"id":318,"slug":319,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":85,"sex":53,"minAge":18,"maxAge":266,"enrollmentInfo":323,"targetDuration":4,"studyType":56,"phases":325,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":45},"100565156","effects-of-walking-apnea-at-low-lung-volume-on-hypoalgesia-100565156","NCT06638515","Effects of Walking Apnea At Low Lung Volume on Hypoalgesia","Inclusion Criteria:\n\n* Asymptomatic subjects aged between 18 and 64 years.\n\nExclusion Criteria:\n\n* Cardiovascular, respiratory, metabolic, neurological or osteomuscular signs or pathologies.\n* History of epilepsy.\n* Pregnant\n* Pharmacological treatment.\n* Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 4 weeks.",{"count":324,"type":22},60,[58],"The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.",[328,329,330,331],"Pain","Hypoxemia","Hypercapnia","Apneas","2024-10-09",{"date":334,"type":37},"2024-10-15",{"date":336,"type":22},"2024-11-01",{"date":338,"type":22},"2025-05-01",{"name":43,"class":44},{"id":341,"slug":342,"hasResults":11,"nctId":343,"briefTitle":344,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":85,"sex":53,"minAge":18,"maxAge":266,"enrollmentInfo":346,"targetDuration":4,"studyType":56,"phases":347,"briefSummary":348,"conditions":349,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":351,"startDateStruct":352,"completionDateStruct":353,"leadSponsor":354,"locationsCount":45},"100565157","effects-of-walking-apnea-at-high-lung-volume-on-hypoalgesia-100565157","NCT06638528","Effects of Walking Apnea At High Lung Volume on Hypoalgesia","Inclusion Criteria:\n\n* Asymptomatic subjects aged between 18 and 64 years.\n\nExclusion Criteria:\n\n* Cardiovascular, respiratory, metabolic, neurological or osteomuscular signs or pathologies.\n\n  * History of epilepsy.\n  * Pregnant\n  * Pharmacological treatment.\n  * Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 4 weeks.",{"count":324,"type":22},[58],"The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.",[328,329,330,350],"Apnea",{"date":334,"type":37},{"date":336,"type":22},{"date":338,"type":22},{"name":43,"class":44},{"id":356,"slug":357,"hasResults":11,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":4,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":56,"phases":364,"briefSummary":365,"conditions":366,"keywords":369,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":379,"completionDateStruct":381,"leadSponsor":383,"locationsCount":45},"100551162","effectiveness-of-non-invasive-neuromodulation-in-patients-with-long-covid-100551162","NCT06456502","Effectiveness of Non-invasive Neuromodulation in Patients With Long-COVID","Effectiveness of Non-invasive Neuromodulation Compared to Placebo on Sleep Quality in Patients With Post-COVID Symptoms: a Randomized Clinical Trial.","Inclusion Criteria:\n\n* Subjects with long COVID or post- acute COVID syndrome\n* With a evolution of at least 6 months after acute SARS-cov-2 infection\n* Whit symptoms present at baseline.\n\nExclusion Criteria:\n\n* Pregnancy.\n* Pacemakers\n* Ulcerations or wounds in the area of electrode application.\n* Decompensated heart disease.\n* Epilepsy and\u002For choreic syndromes.\n* Frequent medication with corticosteroids, hypnotics or supplements such as melatonin, Ashwagandha or phosphatidylserine.\n* Hypersensitivity on hands and feet that influence the use of the gloves and socks from the neuromodulation system.",{"count":363,"type":22},44,[58],"Sleep quality and duration are critical to cognitive, emotional and physical well-being, and poor sleep quality has been associated with an increased risk of cognitive, psychological and cardiometabolic disorders. Several important physiological activities occur during sleep including a reduction in heart rate and blood pressure. In addition, sleep exerts important modulatory effects on hormone release. Previous studies have shown that lack of sleep can generate exaggerated cortisol responses or psychological and physiological stressors. Cortisol has widespread effects throughout the body and brain, affecting mood, arousal, energy, metabolic processes, and immune and inflammatory system functioning. Therefore, disruptions in cortisol secretion during the night can influence a wide variety of processes in our body that may contribute to the perception of poorer sleep quality. In addition, the salivary enzyme α-amylase is considered a biomarker of cognitive, psychosocial, emotional or physical stress. It is important to note that the autonomic nervous system (ANS) regulates several physiological processes, including heart rate, blood pressure, respiration, and digestion. The ANS consists primarily of the sympathetic system and the parasympathetic system. Increased parasympathetic activity is considered to promote health, whereas a dominant or overactive sympathetic branch is considered to be detrimental to health.\n\nA recent study found that both sleep quality and quantity of sleep were associated with resting ANS functioning. They found that poorer sleep quality was associated with greater sympathetic dominance. Research on the sympathetic and parasympathetic branches of the ANS has shown that autonomic imbalances are precursors to disease formation and other health-related risks. Coronavirus disease 2019 (COVID-19), has in many cases involved the presence of long-lasting symptoms several weeks or months after surviving acute infection with the virus, leading to a new disease called long COVID-19 or post-COVID-19 syndrome (PCS). A recent study showed that sleep quality influences the relationship between symptoms associated with sensitization and mood disorders with health-related quality of life in people suffering from long COVID.\n\nNon-invasive neuromodulation directed to ANS may be an option to treat the sleep disorders observed in patients with long COVID.\n\nOBJETIVES:\n\nTherefore, the primary objective of this study is to evaluate the efficacy of a treatment protocol on the ANS by means of non-invasive neuromodulation in aspects related to sleep in long COVID patients compared to placebo. As secondary objectives, we propose to evaluate the efficacy of a treatment protocol on the ANS by non-invasive neuromodulation in aspects related to ANS functioning, psychological variables, fatigue, pain perception and quality of life in patients with long COVID.",[367,368],"Long-COVID","Post-acute COVID-19 Syndrome",[370,367,371,372,373,374,375,123,328],"Post acute COVID-19 syndrome","Non-invasive neuromodulation","Sleep quality","Depression","Anxiety","Fatigue","2024-06-12",{"date":378,"type":37},"2024-06-13",{"date":380,"type":22},"2024-06",{"date":382,"type":22},"2026-06-30",{"name":43,"class":44},{"id":385,"slug":386,"hasResults":11,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":11,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":56,"phases":393,"briefSummary":394,"conditions":395,"keywords":398,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":45},"100482464","predictive-value-of-goccles-device-for-early-diagnosis-of-oral-potentially-malignant-disorders-100482464","NCT05562375","Predictive Value of GOCCLES® Device for Early Diagnosis of Oral Potentially Malignant Disorders","Predictive Value of GOCCLES® (Glasses for Oral Cancer Curing Light Exposed Screening), Device for Early Diagnosis of Oral Potentially Malignant Disorders","Inclusion Criteria:\n\n* Patients older than 18.\n* Patients that present oral mucosa injuries compatible with OPMD.\n* Patients that understand the purpose of the study and express consent\n\nExclusion Criteria:\n\n* Patients that don't have the capability to express consent.\n* Patients with systemic pathologies that contraindicate a biopsy.\n* Patients with a recent biopsy at the oral cavity",{"count":392,"type":22},73,[58],"Oral potentially malignant disorders (OPMDs) are chronic pathologies which can suffer dysplastic alterations and evolve into oral cancer.\n\nThe diagnosis of those pathologies is commonly done by visual inspection, which is not capable of determining the presence or not of dysplasia. Furthermore, this type of diagnosis depends greatly on the expertise and training of the professional.\n\nIn recent years, new methods that can help early oral cancer diagnosis have been developed. A new device has been commercialized, named GOCCLES® (Glasses for Oral Cancer Curing Light Exposed Screening), based on the autofluorescence principle.\n\nThe hypothesis of this study is that GOCCLES® device could be an effective tool to help in early detection of oral cancer.",[396,397],"Oral Potentially Malignant Disorders","Oral Cancer",[399,400,401,402],"GOCCLES","Autofluorescence","Oral cancer","Oral dysplasia","2022-09-30",{"date":405,"type":37},"2022-10-04",{"date":407,"type":37},"2022-01-08",{"date":409,"type":22},"2026-09-30",{"name":43,"class":44},""]