[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad de Almeria\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":239},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,46,77,103,133,160,185,211],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100622672","impact-of-circadian-exercise-on-metabolic-dysfunction-associated-steatotic-liver-disease-in-postmenopausal-women-100622672",false,"NCT07386665","Impact of Circadian Exercise on Metabolic Dysfunction-Associated Steatotic Liver Disease in Postmenopausal Women","Inclusion Criteria:\n\n* Women aged 45-75 years, postmenopausal for at least two years (stage +1a)\n* Body Mass Index (BMI) \\> 25 and \\\u003C 40 kg\u002Fm²\n* Diagnosed hepatic steatosis (via ultrasound hyperechogenicity, FibroScan CAP score \\>280, or histological confirmation)\n* Sedentary lifestyle (no regular structured exercise)\n* Willingness to be randomized and adhere to study procedures, including all assessments and visits\n* Sufficient Spanish proficiency to understand and follow study instructions\n* Consent to store biological samples for future research\n* Participants should have a healthy circadian rhythm\n\nExclusion Criteria:\n\n* Contraindications for MRI (e.g., claustrophobia, pacemaker, metal implants)\n* History of major cardiovascular, endocrine, neurological, or kidney disease, or any clinical abnormalities (to be judged by the study physician)\n* First-degree family history of sudden cardiac death\n* Alcohol or substance abuse\n* Psychiatric, psychotic, eating, or sleep disorders (to be judged by the study physician)\n* Prior bariatric surgery, diagnosed HIV\u002FAIDS, or inflammatory\u002Fautoimmune diseases\n* Cancer or any medical condition where exercise is contraindicated (to be judged by the study physician)\n* Recent or unstable metabolic conditions (e.g., diabetes, recent medication changes, or use of drugs affecting metabolism)\n* Recent (\\\u003C3 months) use of antibiotics, statins, glucocorticoids, hormonal therapies, amiodarone, or myelosuppressive agents\n* Participation in weight-loss programs or special diets (e.g., ketogenic, high-carb)\n* Shift workers or caregivers with frequent nocturnal disruptions","FEMALE","45 Years","75 Years",{"count":19,"type":20},63,"ESTIMATED","INTERVENTIONAL",[23],"NA","Type of Study: Clinical Trial\n\nGoal: The goal of this clinical trial is to investigate how performing exercise at different times of day (morning vs. evening) affects liver fat, cardiometabolic health, and gut microbiota in postmenopausal women.\n\nParticipant Population\u002FHealth Conditions: The study will involve 63 sedentary postmenopausal women (aged 45-75) diagnosed with metabolic dysfunction-associated steatotic liver disease.\n\nMain Questions: The main questions this study aims to answer are:\n\n* Does morning exercise reduce hepatic fat more effectively than evening exercise?\n* How does time-of-day-specific exercise influence cardiometabolic markers?\n* Do changes in gut microbiota contribute to the metabolic effects of exercise timing?\n\nParticipants Will:\n\nBe randomized into one of three groups: morning exercise, evening exercise, or a usual-care control group.\n\nFollow the assigned regimen for 12 weeks. The exercise groups will perform supervised aerobic and resistance training three times per week.\n\nProvide blood, stool, and imaging data before and after the intervention to determine the effects of the intervention.\n\nComparison Group:\n\nResearchers will compare the effects of morning vs. evening exercise (and usual care) on hepatic fat reduction and cardiometabolic improvement, as well as changes in gut microbiota.",[26,27,28],"Metabolic Dysfunction-Associated Steatotic Liver Disease","Cardiometabolic Diseases","Exercise",[28,30,31,32],"Metabolism","Health","Women","NOT_YET_RECRUITING","2026-05-04",{"date":36,"type":37},"2026-05-08","ACTUAL",{"date":39,"type":20},"2026-06-01",{"date":41,"type":20},"2027-12",{"name":43,"class":44},"Universidad de Almeria","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":74,"leadSponsor":76,"locationsCount":45},"100577401","phase-3-tributyrin-treatment-in-mild-alzheimer-disease-assessment-of-butyrate-effects-via-the-gut-brain-100577401","NCT06797817","Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain","TRIM-GUT","Inclusion Criteria:\n\n* individuals diagnosed with mild AD within the past year (ICD-10: F00.1).\n* voluntary consent to participate in the study in accordance with the Declaration of Helsinki.\n* not currently enrolled in any other clinical trial that could confound the results.\n\nExclusion Criteria:\n\n* individuals with other potential causes of dementia, such as a history of severe traumatic brain injury, brain tumours, epilepsy, or central nervous system infections.\n* individuals involved in an intervention that interferes with the trial (immunosuppressive drugs, steroids, antibiotics, or received chemotherapy in the month prior to the start of the intervention).\n* individuals with gastrointestinal disorders.","ALL","18 Years",{"count":56,"type":20},156,[58],"PHASE3","The goal of this clinical trial is to learn if tributyrin can help prevent or mitigate cognitive decline in individuals with mild Alzheimer's disease (AD). The trial will also examine the safety and effects of tributyrin on inflammation and gut microbiota. The main questions it aims to answer are:\n\nDoes tributyrin reduce inflammation and neurodegeneration markers? How does tributyrin affect gut microbiota and intestinal permeability? Researchers will compare tributyrin to a placebo (a look-alike substance that contains no active ingredient) to evaluate its effectiveness.\n\nParticipants will:\n\nTake tributyrin or a placebo every day for 12 weeks. Undergo assessments of cognitive function, blood markers (such as NfL and pTau217), and gut health.\n\nThe findings are expected to provide insight into the potential of tributyrin as a preventive intervention for Alzheimer's disease.",[61],"Alzheimer Disease (AD)",[63,64,65,66,67,68,69],"butyrate","cognitive decline","cytokines","oxidative stress","gut microbiome","tributyrin","alzheimer disease","2025-12-10",{"date":72,"type":37},"2025-12-18",{"date":39,"type":20},{"date":75,"type":20},"2029-09-02",{"name":43,"class":44},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":45},"100587420","inclusive-rehabilitation-virtual-reality-as-a-tool-to-improve-the-quality-of-life-of-dependent-persons-100587420","NCT06928155","Inclusive Rehabilitation: Virtual Reality as a Tool to Improve the Quality of Life of Dependent Persons","Feasibility and Usability of Immersive Virtual Reality for People With Dependency","REVIVIR","Inclusion Criteria:\n\n* Over 18 years of age\n* Patients who agree to participate in the study and sign the informed consent form.\n\nExclusion Criteria:\n\n* Those with severe visual impairment, vertigo, epilepsy or psychosis, and who may interfere with the normal performance of interactive voice response (IVR) tasks, will be excluded as a precaution.",true,{"count":87,"type":20},172,[23],"The project explores the use of virtual reality (VR) as a tool to improve the quality of life of people with dependence, providing immersive and personalized environments that support physical, neurological and psychological rehabilitation. VR makes it possible to practice complex movements, improve strength and coordination, reduce stress and anxiety, and enhance brain plasticity through adapted simulations that are also motivating and safe for users. This approach facilitates more effective rehabilitation than traditional therapies by allowing repetition and visualization of movements that are difficult to perform in real life. The El Saliente Association, in collaboration with the University of Almeria, leads this initiative that seeks to promote the autonomy, inclusion and emotional well-being of people with dependence. With specific objectives such as improving motor function, stimulating neuroplasticity, reducing pain through immersive distraction and enhancing independence, the project uses VR sessions in controlled environments. In addition, activities that simulate everyday situations will be designed to facilitate the transfer of acquired skills to the real environment. The work plan is divided into design, development, implementation and analysis phases, including participant selection, software development, pilot testing and evaluation of results. At each stage, data will be collected to measure the effectiveness of the intervention, with the ultimate goal of publishing the findings in scientific forums and replicating the experience in other contexts. Day center facilities and a residential complex will provide the necessary spaces and materials to carry out the interventions. Expected outcomes include increased motivation and adherence to therapy, faster functional recovery and an overall improvement in quality of life, including increased self-esteem and reduced anxiety. This project promises a significant advance in the use of technology for inclusive rehabilitation, with benefits not only for patients but also for the advancement of innovative therapeutic solutions in the field of dependency.",[91],"People With Dependency",[93],"quality of life, dependency, virtual reality, rehabilitation","RECRUITING","2025-07-28",{"date":97,"type":37},"2025-07-29",{"date":99,"type":37},"2025-06-01",{"date":101,"type":20},"2025-12-28",{"name":43,"class":44},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":85,"sex":53,"minAge":54,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":21,"phases":113,"briefSummary":114,"conditions":115,"keywords":119,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":4},"100600111","epigenetic-optimization-through-biofrequency-nutrition-100600111","NCT07093242","Epigenetic Optimization Through Biofrequency Nutrition","Functional Epigenetic Optimization Through Biofrequency-Guided Nutrition: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years.\n* Active member of a registered athletics club.\n* Willingness to provide a hair sample for genetic analysis.\n* Ability to understand and sign the informed consent form.\n* Commitment to complete the nutritional follow-up (for the intervention group) and to respond to pre- and post-intervention questionnaires.\n\nExclusion Criteria:\n\n* Prior medical diagnosis of a genetic disorder affecting nutritional metabolism.\n* Current use of nutritional supplements or special diets prescribed for medical reasons.\n* Participation in another clinical or nutritional study during the intervention period.\n* Pregnancy or breastfeeding at the time of enrollment.\n* Inability to attend baseline or post-intervention assessments.","65 Years",{"count":112,"type":20},150,[23],"Biomarker-based nutrition has demonstrated superior efficacy compared to population-level approaches in improving health outcomes. Biofrequency analysis, a non-invasive technique based on the detection of electromagnetic vibrational patterns in hair follicles, offers a promising avenue for rapid functional assessment of nutritional status and epigenetic signals without reliance on blood or urine sampling. First, to evaluate the effect of a 90-day biofrequency-guided nutritional intervention on functional epigenetic status, as reflected in changes in the optimization report generated by the S-Drive system; second, to assess changes in adherence to the Mediterranean diet, anthropometric indicators, movement behaviors, and psychological well-being. Methods: In this randomized controlled trial, adults from a Sport Team from Region of Murcia (Spain) will be allocated to an experimental group receiving individualized lifestyle recommendations based on S-Drive biofrequency analysis and to a control group with no intervention. Participants in the experimental arm will apply tailored dietary guidance over 90 days. Conclusion: This study will generate foundational evidence on the utility of biofrequency technology for precision nutrition. If positive, the findings may inform scalable, low-risk strategies for personalized dietary interventions in preventive and community health settings.",[116,117,118],"Nutrition Habits","Biomarkers \u002F Hair","Epigenetic",[120,121,122,123,124],"Biofrequency analysis","young athletes","nutritional intervention","nutritional biomarkers","mediterranean diet","2025-07-22",{"date":127,"type":37},"2025-07-30",{"date":129,"type":20},"2025-10-01",{"date":131,"type":20},"2026-02-01",{"name":43,"class":44},{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":85,"sex":53,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":21,"phases":143,"briefSummary":144,"conditions":145,"keywords":150,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":45},"100540279","whole-body-vibration-therapy-in-the-gait-of-children-with-cerebral-palsy-100540279","NCT06314776","Whole-Body Vibration Therapy in the Gait of Children With Cerebral Palsy","Inclusion Criteria:\n\n* Diagnosis of neurological developmental disorder: Cerebral Palsy. (According to DSM-V)\n* Age between 2 to 11 years.\n* GMFCS I and II.\n* Assessed and\u002For intervened in or from centers, institutions, etc. who collaborate with the University of Almería or participate in them. Specifically from the \"Interactúa\" Child Development and Early Care Center.\n* The subject, father\u002Fmother\u002Flegal guardian of each subject, prior to inclusion in the study, must have signed the informed consent for the participation of himself or his\u002Fher child in it, leaving a record that it could be abandoned if at any time they deem it appropriate and without having to justify it.\n\nExclusion Criteria:\n\n* Diagnosis of Epilepsy.\n* Serious blood circulation problems.\n* Recent operations.\n* Prosthetics.\n* Start of another type of therapy different from the current one.\n* Not having indication for Physiotherapy.","2 Years","11 Years",{"count":142,"type":20},10,[23],"Observation of the effect of vibration therapy on the gait of children with cerebral palsy and the analysis of their functional evolution",[146,147,148,149],"Cerebral Palsy","Neurologic Disorder","Gait Disorders in Children","Hemiplegia",[146,151],"Whole-Body Vibration","2024-12-10",{"date":154,"type":37},"2024-12-16",{"date":156,"type":37},"2024-03-11",{"date":158,"type":20},"2025-09-30",{"name":43,"class":44},{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":21,"phases":170,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":184},"100526258","virtual-reality-software-for-patients-with-stroke-100526258","NCT06132399","Virtual Reality Software for Patients With Stroke","Development and Validation of a Novel Virtual Reality Software for Improving Disability and Quality of Life in Patients With Stroke","RESET","Inclusion Criteria:\n\n* Women and men with either an ischemic or hemorrhagic stroke\n* Stroke between the last 7 to 14 days\n* Functional independence before stroke (modified Rankin scale \\\u003C3)\n* Paresis of the lower extremity, upper extremity, or both, with a score ≤3 on the \"motor arm\" item of the National Institutes of Health Stroke Scale (NIHSS) scale\n* Trunk control in seated and standing position\n* Ability to understand basic instructions and to decide whether to sign informed consent\n\nExclusion Criteria:\n\n* Moderate-severe aphasia that precludes understanding the required tasks\n* Cognitive impairment that precludes cooperation with tasks\n* Serious behavioral problems or mental disorders\n* Lower extremity deep vein thrombosis, quadriplegia, neurodegenerative diseases, lower limb fractures, or recent myocardial infarction\n* Vital organ (heart, lung, liver, kidney, etc.) failure, malignant tumor, or other unstable condition\n* A history of cerebrovascular disease (if not fully resolved)\n* Photosensitive epilepsy",{"count":169,"type":20},96,[23],"The goal os this clinical trial is to develop and validate a gamified, fully immersive, and stroke-specific virtual reality software to improve physical disability and quality of life in patients with stroke.\n\nThe main questions it aims to answer are:\n\n* To assess the effects of a gamified, fully immersive and stroke-specific virtual reality 10-week intervention combined with usual care rehabilitation, compared to usual care rehabilitation alone and in combination with a commercially available VR system, on disability in patients with stroke.\n* To assess the effects of a gamified, fully immersive and stroke-specific virtual reality intervention combined with usual care rehabilitation, compared to usual care rehabilitation alone and in combination with a commercially available virtual reality system, on quality of life, upper-body motor function, gross manual dexterity, handgrip strength, static and dynamic balance, and cognitive function in patients with stroke",[173],"Stroke",[175],"stroke","2024-11-25",{"date":178,"type":37},"2024-11-27",{"date":180,"type":37},"2024-11-15",{"date":182,"type":20},"2025-11",{"name":43,"class":44},4,{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":15,"minAge":54,"maxAge":110,"enrollmentInfo":192,"targetDuration":4,"studyType":21,"phases":194,"briefSummary":195,"conditions":196,"keywords":198,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":4},"100560423","virtual-reality-in-the-treatment-of-pelvic-floor-dysfunction-in-women-with-multiple-sclerosis-100560423","NCT06576947","Virtual Reality in the Treatment of Pelvic Floor Dysfunction in Women With Multiple Sclerosis","Effects of Virtual Reality in the Treatment of Pelvic Floor Dysfunction in Women With Multiple Sclerosis: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Diagnosis of multiple sclerosis\n* Presence of pelvic floor dysfunction\n* Acceptance participation\n* Not undergoing another physical therapy treatment\n\nExclusion Criteria:\n\n* Non-acceptance of participation\n* Mental illness\n* Interruption of adherence to protocolized treatment sessions\n* Indication of surgical treatment in the pelvic floor",{"count":193,"type":20},45,[23],"The purpose of the current randomized clinical trial was to compare the effectiveness of virtual reality versus posterior tibial nerve stimulation on the improvement of pelvic floor dysfunctions in women with multiple sclerosis.",[197],"Multiple Sclerosis",[199,200,201,202],"virtual reality","multiple sclerosis","pelvic floor","randomized controlled trial","2024-08-28",{"date":205,"type":37},"2024-08-29",{"date":207,"type":20},"2024-09-01",{"date":209,"type":20},"2025-12-01",{"name":43,"class":44},{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":85,"sex":15,"minAge":54,"maxAge":219,"enrollmentInfo":220,"targetDuration":4,"studyType":21,"phases":222,"briefSummary":223,"conditions":224,"keywords":225,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":45},"100548829","deciphering-a-novel-and-unique-brown-adipose-tissue-depot-in-women-100548829","NCT06426082","Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women","Deciphering the Molecular and Secretory Functions of a Novel and Unique Brown Adipose Tissue Depot in Women","DEBATE","Inclusion Criteria:\n\n* 18-22 years of age women.\n* BMI between ≥18 and \\\u003C25 kg\u002Fm2\n* Are willing to be randomized to either of these 4 groups.\n* Must be sedentary (i.e., do not perform exercise or go to the gym).\n* Participants should have regular menstrual cycles.\n* Must be willing to adhere to all study procedures, including attendance at all study visits.\n* Must be willing to have biological samples stored for future research.\n* Must accept the use of the Period Calendar and Google Fit Apps on their mobile phones.\n\nExclusion Criteria:\n\n* Diabetes mellitus (determined based on fasting glucose levels defined by ADA criteria).\n* Any other active endocrine disease (thyroid disease, any signs of Cushing's syndrome, adrenal disease and lipid-associated disorders such as familial hypercholesterolemia).\n* Any cardiac disease (i.e., ischemic cardiac disease, arrhythmias, severe heart failure).\n* Use of medication known to influence glucose and\u002For lipid metabolism or brown fat activity (e.g., beta-blockers, antidepressants, corticosteroids).\n* Use of medication shown to increase risk of hypokalemia after salbutamol administration (e.g., xanthine derivatives, steroids and diuretics).\n* Clinically relevant abnormalities in clinical chemistry or electrocardiogram (ECG) at screening (to be judged by the study physician).\n* A first-degree family member with sudden cardiac death.\n* Any chronic renal or hepatic disease.\n* Any other contra-indications for the use of salbutamol or propranolol.\n* Abuse of alcohol or other substances.\n* Smoking.\n* Current participation in another research projects that may influence the current research project.\n* Use of beta-adrenergic receptor agonists (e.g., asthma).\n* Polycystic ovary syndrome.\n* Diagnosed psychotic conditions.","22 Years",{"count":221,"type":20},40,[23],"Type of Study: Clinical Trial\n\nGoal: The goal of this clinical trial is to investigate specific brown and beige fat cells in the dorsocervical area of young, lean adult women.\n\nParticipant Population\u002FHealth Conditions: The study will involve 40 young, lean adult women.\n\nMain Questions: The main questions this study aims to answer are:\n\n* Are there active brown or beige adipocytes in the subcutaneous fat of the dorsocervical area (i.e., iBAT)?\n* What is the secretory function of these adipocytes?\n* How do traditional interventions like cold exposure, as well as new approaches like Beta-2 agonist stimulation and exercise, affect the thermogenesis of these fat cells at the cellular and molecular levels?\n\nParticipants Will:\n\nBe randomized into one of four groups: thermoneutral exposure, cold exposure, aerobic exercise, or Beta-2 agonist treatment.\n\nFollow their assigned regimen for 4 weeks. Provide tissue samples from the dorsocervical area and abdomen before and after the 4-week intervention.\n\nUndergo analysis of these samples using advanced techniques to understand the presence and activity of brown and beige fat cells.\n\nComparison Group: Researchers will compare the effects of different interventions (thermoneutral exposure, cold exposure, aerobic exercise, Beta-2 agonist treatment) on the presence and thermogenesis of brown and beige fat cells in the dorsocervical area.",[27],[226,227,228,229,230],"brown adipose tissue","cold exposure","hot exposure","dorsocervical fat","exercise","2024-05-20",{"date":233,"type":37},"2024-05-23",{"date":235,"type":20},"2024-11-01",{"date":237,"type":20},"2026-08",{"name":43,"class":44},""]