[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad de Burgos\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":156},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,77,103,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100639307","immersive-virtual-reality-versus-conventional-physiotherapy-for-shoulder-tendinopathy-100639307",false,"NCT07592156","Immersive Virtual Reality Versus Conventional Physiotherapy for Shoulder Tendinopathy","Efficacy of Immersive Virtual Reality Compared With Conventional Physiotherapy in the Management of Shoulder Tendinopathy: A Randomized Controlled Pilot Study","HOMVR","Inclusion Criteria:\n\n* Confirmed diagnosis of shoulder tendinopathy.\n* Referral to the shoulder rehabilitation program.\n* Age between 18 and 80 years.\n* Willingness to use immersive virtual reality headsets.\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Acute or exacerbated phase of shoulder tendinopathy, defined as resting pain greater than 7 points on a 0-to-10 Numeric Rating Scale.\n* Simultaneous participation in another clinical study.\n* Current physiotherapy treatment for the same shoulder condition.\n* Recent infiltrative treatment within the previous 3 months.\n* Any condition contraindicating the use of immersive virtual reality, including photosensitive epilepsy, severe vertigo, claustrophobia, or active ocular or facial infections.\n* Intolerance to the use of virtual reality headsets.","ALL","18 Years","80 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","Immersive virtual reality (VR) has emerged as a promising tool to support therapeutic exercise by increasing patient motivation, promoting movement through gamification, and potentially reducing pain perception during movement. However, evidence regarding its use in shoulder tendinopathy remains limited.\n\nThis randomized controlled pilot study will evaluate the clinical efficacy and feasibility of an immersive VR-based exercise program compared with conventional physiotherapy in patients with shoulder tendinopathy. A total of 20 patients referred to the Rehabilitation Department of Hospital Universitario de La Línea de la Concepción will be randomly allocated to either a conventional therapeutic exercise group or an immersive VR-based exercise group. Both interventions will last 4 weeks, with 3 sessions per week, for a total of 12 sessions.\n\nThe primary outcome will be shoulder pain and disability measured with the Shoulder Pain and Disability Index (SPADI). Secondary outcomes will include pain intensity, upper limb function, shoulder range of motion, isometric strength, kinesiophobia, and patient satisfaction. Outcomes will be assessed at baseline and immediately after the 4-week intervention",[28],"Shoulder Tendinopathy",[30,31],"rotator cuff tendinopathy","shoulder pain","NOT_YET_RECRUITING","2026-05-11",{"date":35,"type":36},"2026-05-18","ACTUAL",{"date":38,"type":22},"2026-05-01",{"date":40,"type":22},"2026-12-01",{"name":42,"class":43},"Universidad de Burgos","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100619390","eficac-ttr-trial-exercise-and-nutritional-supplementation-in-transthyretin-cardiac-amyloidosis-100619390","NCT07343999","EFICAC-TTR Trial: Exercise and Nutritional Supplementation in Transthyretin Cardiac Amyloidosis","A Prospective, Randomized, Multicenter Clinical Trial on the Effect of a Home-Based Multicomponent Exercise Program Combined With Nutritional Supplementation in Patients With Transthyretin Cardiac Amyloidosis","EFICAC-TTR","Inclusion Criteria:\n\n* Age ≥70 years.\n* Confirmed diagnosis of transthyretin cardiac amyloidosis (TTR-CA) based on positive bone scintigraphy with diphosphonates (Perugini grade 2 or 3) and absence of monoclonal protein.\n* Clinical stability during the 4 weeks prior to enrollment.\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Light-chain (AL) amyloidosis or other non-TTR amyloidosis variants.\n* Absolute medical contraindication to moderate-intensity exercise.\n* Severe comorbid conditions with an estimated life expectancy \\\u003C6 months.\n* Severe cognitive impairment (Mini-Mental State Examination score \\\u003C20).\n* Concurrent participation in another clinical trial or structured exercise program.\n* Known allergy or intolerance to creatine, beta-hydroxy-beta-methylbutyrate (HMB), or microcrystalline cellulose.\n* Severe renal impairment requiring dialysis.","70 Years",{"count":55,"type":22},102,[25],"Transthyretin cardiac amyloidosis (TTR-CA) is a heart disease that mainly affects older adults and often leads to reduced physical capacity, muscle weakness, frailty, and a decline in quality of life. While current medical treatments can slow disease progression, they do not fully address functional limitations or muscle deterioration.\n\nThe EFICAC-TTR study is a prospective, randomized, multicenter clinical trial designed to evaluate whether a combined non-pharmacological intervention can improve physical function in patients aged 70 years or older with confirmed TTR-CA.\n\nA total of 102 participants will be randomly assigned to one of three groups: (1) usual medical care, (2) a home-based multicomponent exercise program combined with fiber supplementation, or (3) the same exercise program combined with creatine monohydrate and β-hydroxy-β-methylbutyrate (HMB) supplementation. The exercise program is adapted to each participant's functional level and is performed at home.\n\nThe main outcomes of the study are changes in walking capacity, measured by the 6-minute walk test, and muscle strength, assessed by handgrip strength after 12 weeks. Secondary outcomes include changes in body composition, frailty, quality of life, and clinical events, while mechanistic biomarkers are assessed as exploratory outcomes.\n\nThis study aims to determine whether combining exercise with nutritional supplementation can safely improve functional capacity and overall health in older adults with transthyretin cardiac amyloidosis.",[59],"Transthyretin Cardiac Amyloidosis",[61,62,63,64,65,66,67,68,59],"Exercise Training","Nutritional Supplementation","Creatine","Beta-Hydroxy Beta-Methylbutyrate","Older Adults","Functional Capacity","Frailty","Cardiac Amyloidosis","2026-02-10",{"date":71,"type":36},"2026-02-11",{"date":73,"type":22},"2026-06",{"date":75,"type":22},"2027-09",{"name":42,"class":43},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":44},"100609321","effects-of-chronic-creatine-and-beta-hydroxy-beta-methylbutyrate-supplementation-on-oxidative-stress-inflammation-muscle-strength-and-body-composition-in-individuals-with-down-syndrome-100609321","NCT07213063","Effects of Chronic Creatine and Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Oxidative Stress, Inflammation, Muscle Strength, and Body Composition in Individuals With Down Syndrome","Inclusion Criteria:\n\n* Diagnosis: Medical confirmation of Down syndrome (trisomy of chromosome 21).\n* Physical capacity: Ability to perform basic physical tests (e.g., standing up from a chair or walking without assistance).\n* Informed consent: Informed consent will be obtained from both the participant and their legal representative, in compliance with current legislation for individuals requiring support measures.\n\nExclusion Criteria:\n\n* Chronic kidney disease: Diagnosis of chronic kidney disease.\n* Severe motor limitations: Inability to perform the required physical tests (e.g., paralysis or mobility impairments preventing the execution of muscle strength assessments).\n* Participation in other studies: Participation in another nutritional or supplementation intervention study within the last 6 months.\n* Allergies or intolerances: Known allergy to creatine or to components of the placebo (inulin).",{"count":84,"type":22},50,[25],"Purpose:\n\nThis study will test whether 8 weeks of creatine and HMB supplementation can improve muscle strength, body composition, balance, and overall health in people with Down syndrome. Participants will also receive nutrition tips during the study.\n\nWho can participate:\n\nPeople with Down syndrome who can perform basic physical tasks. Must provide consent from the participant and legal guardian.\n\nWhat participants will do:\n\nTake creatine (3 g\u002Fday) and HMB (3 g\u002Fday) or placebo for 8 weeks. Complete tests for muscle strength, balance, and cognitive function. Undergo body composition scans and give blood samples for health markers.\n\nTiming:\n\nAll tests and blood samples are taken before and after each 8-week period.\n\nImportance:\n\nResults will help determine if creatine and HMB can safely improve strength, balance, and overall health in people with Down syndrome.",[88,89],"Down Syndrome (DS)","Supplementation",[91,92,93],"creatine","down syndrome","bone mineral health","RECRUITING","2026-01-12",{"date":97,"type":36},"2026-01-14",{"date":99,"type":36},"2025-09-15",{"date":101,"type":22},"2026-05-30",{"name":42,"class":43},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":119,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100565176","functional-electrostimulation-on-the-upper-lip-in-multiple-sclerosis-100565176","NCT06638775","Functional Electrostimulation on the Upper Lip in Multiple Sclerosis","RESEARCH PROJECT on the APPLICATION of FUNCTIONAL ELECTROSTIMULATION on the UPPER LIMB in MULTIPLE SCLEROSIS","EM\u002F2024","Inclusion Criteria:\n\n* Be of legal age and sign the informed consent form.\n* Not suffer from any pathology in the upper limb such as tendinitis, oedema, fractures, etc.\n* Intact skin (no breaks, scratches, cuts, and other superficial or deep injuries) on the arm where the devices will be placed if applicable\n\nExclusion Criteria:\n\n* Severe medical problems.\n* Use of a pacemaker.\n* Pregnancy.\n* Cutaneous neuropathies.\n* Presence of other neuromuscular pathologies.",{"count":112,"type":22},30,[25],"Multiple sclerosis (MS) is an autoimmune disease where immune cells attack the body, triggering an inflammatory response. A study comparing multifield FES and conventional FES on upper extremity motor skills and functional independence in MS patients will be conducted. Results suggest that both types of FES treatments normalize muscle tone, showing superior results compared to those without FES therapy. The study aims to compare the effects of both types on MS patients.",[116,117,118],"Electrode Site Reaction","Therapy","Directly Observed Therapy",[120,121,122,123],"fesia grasp","multiple sclerosis","multicampe","therapy","2024-10-10",{"date":126,"type":36},"2024-10-15",{"date":128,"type":22},"2025-01-20",{"date":130,"type":22},"2025-09-20",{"name":42,"class":43},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":140,"minAge":141,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":23,"phases":144,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":155,"locationsCount":44},"100564030","significant-activities-in-the-integrated-person-centered-care-model-100564030","NCT06623864","Significant Activities in the Integrated Person-centered Care Model","Significant Activities in the Implementation of the Integrated Person-centered Care Model: Intervention Protocol","IO\u002F20240924","Inclusion Criteria:\n\n* That the direct care worker has a degree as a nursing assistant, dependency care technician, geroculturist or certificate of professionalism.\n* The worker must speak and understand Spanish.\n* The residence must offer service during the day, in the morning or afternoon shift.\n* Workers must have been with the department for more than 4 months.\n\nExclusion Criteria:\n\n* Workers who work night shift only.\n* Workers on rotating shifts in all departments of the residence.\n* Workers absent at the time of the study due to temporary leave, vacations or other causes.","MALE","60 Years",{"count":143,"type":22},10,[25],"The increasing life expectancy and global aging population necessitate changes in long-term gerontological services based on Person-Centred Care approaches. This study aims to improve Person-Centred Care in geriatric centers through meaningful activities and the role of occupational therapists and direct care professionals in developing these activities. A descriptive cross-sectional quasi-experimental design was proposed, with 10 participants.",[147,148],"Old Age; Dementia","Old Age; Debility","2024-09-30",{"date":151,"type":36},"2024-10-02",{"date":153,"type":36},"2024-09-24",{"date":128,"type":22},{"name":42,"class":43},""]