[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad de Especialidades Espiritu Santo\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":251},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,47,79,95,122,150,179,203,227],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100053606","clinical-performance-and-quality-of-life-of-3d-printed-complete-dentures-under-digital-vs-hybrid-workflows-a-randomized-crossover-trial-100053606",false,"NCT07626827","Clinical Performance and Quality of Life of 3D-Printed Complete Dentures Under Digital vs Hybrid Workflows: A Randomized Crossover Trial","Clinical Success, Oral Health-Related Quality of Life, and Relationship Between Maximum Masticatory Force and Denture Wear in Complete Dentures Fabricated by Additive Manufacturing Under Digital and Hybrid Workflows: A Prospective Randomized Crossover Clinical Trial","PRINT-DENT","Inclusion Criteria:\n\n* Completely edentulous (bimaxillary)\n* Age between 50 and 90 years\n* Able to understand and sign informed consent\n* No cognitive or psychological deficits that interfere with study participation\n\nExclusion Criteria:\n\n* Unimaxillary edentulism\n* Presence of Kelly syndrome\n* Presence of flabby tissue on alveolar ridges\n* No prior experience with complete dentures\n* Chronic motor disorders that may compromise prosthetic function","ALL","50 Years","90 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective randomized crossover clinical trial evaluates and compares the clinical performance and oral health-related quality of life (OHRQoL) of complete dentures fabricated through two additive manufacturing workflows - digital and hybrid - in edentulous patients attending the Dental Clinic of Universidad de Especialidades Espíritu Santo (UEES), Samborondón, Ecuador.\n\nIn the digital workflow, complete dentures are fabricated using direct intraoral scanning of edentulous ridges, CAD design, and 3D printing. In the hybrid workflow, conventional functional impressions are digitized, followed by CAD design and additive manufacturing of the definitive dentures.\n\nEach eligible participant receives two complete denture sets in a randomized crossover sequence (no washout period): Denture Set 1 is worn for 2 months, after which the participant crosses over to Denture Set 2, worn for an additional 2 months. Total active follow-up per participant is approximately 4 months. Following completion of the crossover phase, denture wear is monitored longitudinally for 12 months from the insertion of the second denture set (total study duration approximately 16 months per participant).\n\nThe study addresses three specific objectives:\n\nTo determine the clinical success rate of complete dentures fabricated by additive manufacturing under digital and hybrid workflows, evaluating retention, stability, denture base adaptation, occlusal balance, and need for clinical adjustments.\n\nTo evaluate the impact of complete denture treatment on OHRQoL using the validated OHIP-EDENT questionnaire, assessed at the insertion of each denture set and at the 2-month control of each period (4 measurement points total).\n\nTo evaluate the relationship between maximum masticatory force (T-Scan digital occlusal analysis system) and denture wear (volumetric 3D digital metrology via STL superimposition), with wear monitored over 12 months from insertion of the second denture set.",[28],"Complete Edentulism",[30,31,32,33],"hybrid workflow","complete denture","digital workflow","complete edentulous","RECRUITING","2026-07-09",{"date":37,"type":38},"2026-07-13","ACTUAL",{"date":40,"type":38},"2026-07-01",{"date":42,"type":22},"2027-11-30",{"name":44,"class":45},"Universidad de Especialidades Espiritu Santo","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100617518","community-based-social-connection-intervention-program-to-improve-cardiovascular-and-brain-health-100617518","NCT07319663","Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health","Quasi-experimental Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health in Older Adults Living in Rural Ecuador","Inclusion Criteria:\n\nAge 60 years or older Permanent resident of the community for at least one year Able to provide written informed consent Able to participate in community activities and home-based assessments No plans to relocate during the 12-month follow-up\n\nExclusion Criteria:\n\nSevere disability that prevents participation in study activities Diagnosed dementia, major psychiatric illness, or severe cognitive impairment History of stroke with significant functional limitation Terminal illness or medical condition that precludes follow-up\n\n\\-",true,"60 Years",{"count":57,"type":22},500,[25],"This study evaluates the effectiveness of a community-based social connection intervention program (SCIP) designed to reduce social isolation and loneliness and improve cardiovascular and brain health among older adults living in rural Ecuador. Loneliness and social isolation are recognized risk factors for poor cardiovascular outcomes, cognitive decline, depression, and reduced quality of life. However, evidence from low- and middle-income countries, particularly in rural Latin American settings, remains limited. This protocol describes a quasi-experimental, longitudinal study conducted in three rural villages that have been part of a long-standing population-based cohort.\n\nThe intervention will be implemented in one community and compared with two similar communities that will continue receiving usual community activities. SCIP consists of three components: (1) monthly community activities and educational talks designed to promote social participation; (2) monthly peer-support group sessions facilitated by trained personnel; and (3) individualized home-based coaching delivered twice per month, incorporating principles of Social Cognitive Theory and Cognitive Behavioral Therapy. The program aims to strengthen social networks, enhance coping skills, and promote healthier behaviors.\n\nParticipants aged 60 years and older will be enrolled and followed for 12 months. Assessments will occur at baseline, 6 months, and 12 months. Primary outcomes include changes in social isolation (Lubben Social Network Scale-6) and loneliness (De Jong Gierveld Scale). Secondary outcomes include cardiovascular health (Life's Essential 8), sleep quality (Pittsburgh Sleep Quality Index), cognitive performance (Montreal Cognitive Assessment), depressive symptoms (DASS-21), and quality of life (SF-36). Exploratory outcomes include incident stroke, cardiovascular events, and mortality, monitored through ongoing community surveillance.\n\nThis study will generate evidence on the feasibility and impact of a culturally adapted, community-based intervention to promote social connection and healthy aging in a resource-limited rural setting. Findings may inform scalable public health strategies for older adults in similar contexts.",[61,62,63,64],"Social Isolation in Older Adults","Loneliness","Stroke","Cognitive Decline",[66,62,67,68,69,70],"Social isolation","Social support","Community Health Services","Rural population","Aged","2026-06-09",{"date":73,"type":38},"2026-06-11",{"date":75,"type":38},"2026-06-01",{"date":77,"type":22},"2027-06-01",{"name":44,"class":45},{"id":80,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":26,"conditions":85,"keywords":86,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":46},"100638159","Inclusion Criteria:\n\nCompletely edentulous (bimaxillary) Age between 50 and 80 years Able to understand and sign informed consent No cognitive or psychological deficits that interfere with study participation\n\nExclusion Criteria:\n\nUnimaxillary edentulism Presence of Kelly syndrome Presence of flabby tissue on alveolar ridges No prior experience with complete dentures Chronic motor disorders that may compromise prosthetic function","85 Years",{"count":21,"type":22},[25],[28],[30,31,32,33],"2026-05-31",{"date":89,"type":38},"2026-06-04",{"date":91,"type":22},"2026-06-02",{"date":93,"type":22},"2027-10-30",{"name":44,"class":45},{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":54,"sex":17,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":107,"studyType":108,"phases":4,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":46},"100630284","genesis-project-generating-evidence-on-the-needs-of-ecuadorian-adolescents-100630284","NCT07485673","GENESIS Project: Generating Evidence on the Needs of Ecuadorian Adolescents","Generating Evidence on the Needs of Ecuadorian Adolescents","GENESIS","Inclusion Criteria:\n\n* be between 14 and 19 years old\n\nExclusion Criteria:\n\n* have any disorder or treatment that contraindicated physical activity or that demanded special assistance\n* be under some pharmacological treatment;\n* not be authorized by parents, caregivers, or legal guardians to participate in the research project\n* do not agree to take part in the research project\n* for volunteering retirement.","14 Years","19 Years",{"count":106,"type":22},1450,"5 Years","OBSERVATIONAL","Background: Adolescence is a period of intensified emotional responses and occurs when mental health disorders commonly develop since adolescents are learning how to deal with powerful emotions. Globally, 15% of adolescents experience a mental disorder like depression or anxiety. However, adolescent mental health goes beyond mental disorders. It is state of mental well-being that allows individuals to deal with stressors, recognize their abilities, develop their activities well, and participate in society, providing a holistic approach that highlights the interplay between psychological well-being and other aspects of life. Given this perspective, a Lifestyle Medicine (LM) approach based on a multi-component framework is needed for assessing adolescents' mental health. This study aims to evaluate adolescents' (aged 14-19) mental health, identify and mitigate the risks of developing any mental health disorder as well as formulate comprehensive interventions to promote and increase their emotional wellbeing. Methods: Cross-sectional and longitudinal studies will be performed. Adolescents from Quito, Ecuador will be recruited using a simple random sampling technique. The minimum sample size is 385; however, to increase the precision of the estimates, a target sample of approximately 1000 participants will be established. Main outcome measure will be mental health using social determinants of health and lifestyle medicine factors. Conclusion: This research project will evaluate adolescents' mental health through a holistic and multiapproach evaluation and interrelate social determinants of health and lifestyle medicine variables to propose and design multidisciplinary strategies and interventions to prevent and mitigate mental health outcomes in adolescents. Additionally, the results will be useful in informing public health authorities to evaluate or modify current policies",[111,112,113],"Adolescent Development","Mental Health Issue","Lifestyle Factors","2026-03-16",{"date":116,"type":38},"2026-03-20",{"date":118,"type":38},"2025-09-04",{"date":120,"type":22},"2030-08",{"name":44,"class":45},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":54,"sex":17,"minAge":129,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":23,"phases":133,"briefSummary":134,"conditions":135,"keywords":138,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":46},"100566920","bone-augmentation-techniques-in-the-mandible-posterior-region-100566920","NCT06661447","Bone Augmentation Techniques in the Mandible Posterior Region","Comparison of Bone Augmentation Techniques in the Mandibular Posterior Region: A Randomized Clinical Trial","Inclusion Criteria:\n\nPosterior mandibular edentulism requiring horizontal ridge augmentation (Cawood \\& Howell Classes IV-VI).\n\nOne or two eligible posterior mandibular sites suitable for cortical shell augmentation.\n\nAdequate residual bone height to allow safe fixation above the mandibular canal.\n\nGood general health (ASA I or II). Plaque index \\\u003C 20% and absence of active periodontal infection. Ability and willingness to attend scheduled follow-up visits (up to 12 months). Written informed consent provided prior to any study-related procedure.\n\nExclusion Criteria:\n\nUncontrolled systemic diseases affecting bone healing (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders).\n\nCurrent heavy smoking (\\>5 cigarettes\u002Fday). Pregnancy or lactation. Current use of medications known to affect bone metabolism or healing (e.g., bisphosphonates, long-term corticosteroids, anticoagulants).\n\nActive periodontal disease or untreated oral infection. History of chemotherapy or radiotherapy to the head and neck region.","18 Years","64 Years",{"count":132,"type":22},78,[25],"This study will compare three methods to rebuild lost bone in the back part of the lower jaw (posterior mandible) before dental implant placement. Seventy-eight adults will be randomly assigned to receive one of three \"cortical shell\" techniques using either the patient's own bone (autogenous) or prefabricated bone plates from animal (xenogeneic) or human donors (allogeneic). In all groups, the space inside the shell will be filled with a mixture of small bone chips and bone substitute material. The main outcome is the increase in jawbone width measured on 3D cone-beam CT scans at 6 months after surgery. Additional scans and clinical assessments up to 12 months will evaluate healing, bone stability, and postoperative recovery.",[136,137],"Bone Substitutes","Alveolar Bone Grafting",[139,136,140],"Alveolar Bone Atrophy","Bone Resorption","NOT_YET_RECRUITING","2026-02-18",{"date":144,"type":38},"2026-02-20",{"date":146,"type":22},"2026-04-01",{"date":148,"type":22},"2027-04-01",{"name":44,"class":45},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":54,"sex":17,"minAge":129,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":159,"briefSummary":160,"conditions":161,"keywords":163,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":4},"100599278","biofrequency-guided-nutrition-in-spanish-adults-100599278","NCT07082413","Biofrequency-Guided Nutrition in Spanish Adults","Application of a Frequency Measurement System for Measuring Nutritional Biomarkers: Effects of a Nutritional Intervention on Satisfaction and Improvement in Quality of Life","Inclusion Criteria:\n\n* No diagnosed chronic illnesses.\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* Diagnosed chronic illnesses\n* No provision of written informed consent.",{"count":158,"type":22},154,[25],"The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary efficacy of a biofrequency-guided nutritional intervention in promoting a healthy diet, improving dietary behaviors, and enhancing user satisfaction among healthy Spanish adults. The present study aims to address four main objectives: (1) to analyze the utility of the biofrequency system for non-invasive functional estimates of nutritional status; (2) to evaluate the effectiveness of the associated algorithm in generating bi-omarker-informed dietary recommendations; (3) to assess user and healthcare profes-sional acceptance and satisfaction with the tool; and (4) to examine the effects of the intervention on eating habits.",[162],"Biofrequency-Guided Nutrition",[164,165,166,167,168,169,170],"Biofrequency analysis","biomarker-based nutrition","dietary habits","mediterranean diet","nutritional biomarkers","nutritional intervention","young athletes","2025-07-15",{"date":173,"type":38},"2025-07-24",{"date":175,"type":22},"2025-09-01",{"date":177,"type":22},"2026-03",{"name":44,"class":45},{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":54,"sex":17,"minAge":129,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":23,"phases":188,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":46},"100566952","effectiveness-of-alveolar-bone-preservation-in-alveoli-with-infectious-process-100566952","NCT06661863","Effectiveness of Alveolar Bone Preservation in Alveoli With Infectious Process","Effectiveness of Autologous Bone and Bioactive Glass for Alveolar Preservation in Alveoli With Infectious Process","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patients with indicated tooth extractions\n* Patients who have accepted the conditions of the study\n\nExclusion Criteria:\n\n* Pregnant patients, breastfeeding or using oral contraceptives\n* Smoking patients\n* Patients with uncontrolled systemic diseases\n* History of autoimmune disease\n* Previous traumatic extraction\n* Patients taking bisphosphonates or anticoagulants\n* Patients who are or have undergone chemotherapy and radiotherapy",{"count":187,"type":22},28,[25],"Alveolar ridge preservation (ARP) is a surgical technique that aims to minimize the degree of dimensional changes following extraction. In the healing period after extraction, the alveolar bone (AB) undergoes morphological changes during the remodeling process. The changes become evident immediately after tooth extraction, with greater resorption changes observed during the first two months, and these dimensional changes can be observed 1 year after surgery.",[191],"Alveolar Bone Loss",[193,194,136,137],"Alveolar Resorption","Alveolar process","2024-10-25",{"date":197,"type":38},"2024-10-28",{"date":199,"type":22},"2024-11-15",{"date":201,"type":22},"2029-12-15",{"name":44,"class":45},{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":54,"sex":17,"minAge":129,"maxAge":130,"enrollmentInfo":211,"targetDuration":4,"studyType":23,"phases":213,"briefSummary":214,"conditions":215,"keywords":217,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":226,"locationsCount":46},"100560720","efficacy-of-the-modified-free-gingival-graft-technique-100560720","NCT06580821","Efficacy of the Modified Free Gingival Graft Technique","Evaluation of the Efficacy of the Modified Free Gingival Graft Technique","FGG","Inclusion Criteria:\n\n* Patients with at least two or less localized recession in mandibular incisors\n* Cairo type 1 recession\n* Patients who have good plaque control of less than 20%\n* Patients between 18-64 years old\n\nExclusion Criteria:\n\n* Systemically compromised patients\n* Smoker patients\n* Pregnant women, breastfeeding or use of oral contraceptives\n* Patients who are taking medication that may affect healing and coagulation\n* Previous periodontal surgeries in the RG area\n* Patients with periodontal disease\n* Patients who have undergone chemotherapy and radiotherapy",{"count":212,"type":22},30,[25],"Gingival recessions can be defined as the exposure of the root surface after an apical migration of the gingival margin in relation to the cemento-enamel junction. Gingival recessions affect both younger and older populations. Various surveys revealed that 88% of people ≥65 years of age and 50% of people between 18 and 64 years of age have ≥1 site with gingival recession. Gingival recessions can occur due to anatomical, pathological factors or trauma and will result in a loss of attachment.",[216],"Modified Free Gingival Graft , Connective Tissue Graft",[218,219,220],"Gingival Recession","Surgical Flaps","Connective Tissue",{"date":222,"type":38},"2024-10-29",{"date":224,"type":38},"2024-09-01",{"date":201,"type":22},{"name":44,"class":45},{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":54,"sex":17,"minAge":129,"maxAge":4,"enrollmentInfo":233,"targetDuration":4,"studyType":23,"phases":234,"briefSummary":235,"conditions":236,"keywords":239,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":250,"locationsCount":46},"100561677","pain-perception-in-protection-of-the-palatal-donor-area-after-harvesting-a-free-gingival-graft-using-flowable-resin-versus-a-self-adhesive-dressing-100561677","NCT06593275","Pain Perception in Protection of the Palatal Donor Area After Harvesting a Free Gingival Graft Using Flowable Resin Versus a Self-adhesive Dressing","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patients with plaque control less than 20%\n* Patients with bleeding on probing less than 10%\n* Patients in need of periodontal or peri-implant surgery in the upper or lower jaw\n* Not having previous surgeries in the donor area\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding patients\n* Patients with lesions in the palate\n* Patients who use prostheses that cover the palate\n* Patients with active periodontal disease\n* Patients who smoke\n* Patients with systemic diseases\n* Torus palatinus\n* Patients with a history of chemotherapy and radiotherapy",{"count":212,"type":22},[25],"The use of a connective tissue graft harvested from the palate is currently one of the most effective and predictable alternatives for the correction of periodontal and peri-implant defects, but the discomfort generated in the palate is sometimes greater than mucogingival surgery. For this reason, we found the need to use different materials for palatal protection. In one group we will use light-cured fluid resin compared to another group a self-adhesive dressing to check which of these materials provides less postoperative pain generated by the harvest of a free gingival graft.",[237,238],"Perception of Pain","Protection of the Palate",[240,241,242,243],"protection of the palate","pain palate","flow resine","self-adhesive dressing","2024-10-07",{"date":246,"type":38},"2024-10-10",{"date":248,"type":22},"2024-10-30",{"date":201,"type":22},{"name":44,"class":45},""]