[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad de La Frontera\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":304},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,47,79,107,138,166,194,224,247,276],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100596639","prehabilitation-in-older-people-undergoing-total-hip-replacement-100596639",false,"NCT07048080","Prehabilitation in Older People Undergoing Total Hip Replacement","(P)Rehabilitation in Older People With Osteoarthritis Undergoing Total Hip Replacement : From Physicological Mechanism to Clinical Benefits","PREHIP","Inclusion Criteria:\n\n* Individuals aged from 60 y and over.\n* 18.5 \\\u003C BMI \\\u003C 40 kg\u002Fm2.\n* Individuals on waiting list to undergo a unilateral elective surgery for Total Hip Replacement due to primary severe Osteoarthritis.\n\nExclusion Criteria:\n\n* Individuals with severe OA in the contralateral hip.\n* Individuals who has been performing regular RET (2 or more times per week) in the previous 6 months.\n* Individuals who smoke.\n* Significant psychiatric or neurological disorders, with the use of acetylcholinesterase inhibitors, and untreated mood disorders or depressive pathology.\n* Neuromuscular or mobility disorders that prevent safe resistance training (debilitating arthritis, spasticity\u002Frigidity, and paralysis), along with untreated metabolic disorders (such as uncontrolled systemic hypertension).","ALL","60 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to determine the effect of Resistance Exercise Training (RET)-based (p)rehabilitation versus usual care on skeletal muscle mass and function, as well as on underlying biological processes, in older adults undergoing elective Total Hip Replacement (THR) due to severe Osteoarthritis (OA). The main questions it aims to answer are:\n\n* What is the effects of RET-based (p)rehabilitation versus usual care to improve muscle mass and function in patients undergoing elective unilateral THR surgery for end-stage OA?\n* What is the potential of certain circulating biomarkers to predict the efficacy of the musculoskeletal system response to RET in patients with severe OA? Researchers will compare RET-based (p)rehabilitation versus usual care to see if RET works to increase skeletal muscle mass and function.\n\nParticipants in the usual care group will undergo standard rehabilitation (12 weeks post-surgery), and participants in the (p)rehabilitation group will undergo RET-based full-body (p)rehabilitation (3x\u002Fweek) for 2 weeks pre-surgery and 12 weeks post-surgery.",[27,28],"Hip Replacement in Osteoarthritis Patients","Osteoarthritis, Hip",[30,31,32,33],"hip osteoarthritis","total hip replacement","resistance exercise training","older people","NOT_YET_RECRUITING","2026-06-10",{"date":37,"type":38},"2026-06-12","ACTUAL",{"date":40,"type":21},"2026-08-02",{"date":42,"type":21},"2029-03",{"name":44,"class":45},"Universidad de La Frontera","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":72,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100539857","prehabilitation-with-resistance-exercise-training-for-breast-cancer-neoadjuvant-therapy-100539857","NCT06309290","Prehabilitation With Resistance-exercise Training for Breast Cancer Neoadjuvant Therapy","Prehabilitation Based on Resistance-exercise Training in Women With Breast Cancer Undergoing Neoadjuvant Therapy: From Molecular Mechanism to Clinical Benefits","NEO STRONG","Inclusion Criteria:\n\n* Postmenopausal women with breast cancer in stages I, II and III with luminal breast tumor, HER2+ or TNBC\n* Indication for neoadjuvant chemotherapy\n* Candidates for curative breast surgery\n* Body mass index: 18.5 \\\u003CBMI \\\u003C30 kg\u002Fm2\n* Sedentary (does not perform scheduled or planned physical activity ≥ 2 times a week)\n* Willingness to participate in the study and follow the proposed prehabilitation scheme.\n\nExclusion Criteria:\n\n* Present comorbidities that interact with the metabolism and mobility of the muscles of the body and that do not allow the (safe) performance of strength exercises (e.g., debilitating arthritis, all neurological disorders, paralysis, among others).\n* Severe or uncontrolled cardiovascular disease, cardiac ejection fraction less than 50%\n* Previous antineoplastic treatment\n* Use of nutritional supplements (leucine, glutamine, casein, whey protein, fatty acids and creatine).",true,"FEMALE",{"count":58,"type":21},68,[24],"Breast cancer stands as the foremost cause of cancer-related deaths among women worldwide, with the highest incidence of any cancer type. The choice of therapeutic interventions hinges upon factors like cancer stage, cell subtype, and tumor size. Consequently, individuals with more aggressive tumors, such as HER+2 and Triple Negative, or larger tumors often undergo neoadjuvant chemotherapy before breast surgery. However, these anticancer treatments come with side effects like cancer-related fatigue, reduced functional capacity, and changes in body composition, notably skeletal muscle atrophy. Skeletal muscle loss correlates with heightened mortality rates, cardiotoxicity, and diminished quality of life, underscoring the need for early therapeutic interventions. One such promising strategy is prehabilitation, which involves resistance-exercise training aimed at bolstering skeletal muscle mass from the outset of the disease, even preceding breast surgery. Resistance-exercise training has shown favorable effects on women undergoing adjuvant therapy or survivors of breast cancer, however, its molecular and clinical effects in women with breast cancer undergoing neoadjuvant therapy are unknown.",[62,63,64,65],"Prehabilitation","Breast Cancer","Postmenopause","Resistance Training",[62,67,68,69,70],"Breast neoplasm","Strength Training","Skeletal muscle","Muscle strength","RECRUITING",{"date":37,"type":38},{"date":74,"type":38},"2025-01-01",{"date":76,"type":21},"2026-12",{"name":44,"class":45},2,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":56,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":46},"100637207","effects-of-a-neurorehabilitation-program-based-on-cimt-and-non-invasive-neuromodulation-through-c-tdcs-on-the-recovery-of-paretic-upper-limb-function-quality-of-life-and-therapeutic-alliance-in-women-from-the-araucana-region-who-suffered-a-stroke-cimt--tdcs-100637207","NCT07619703","Effects of a Neurorehabilitation Program Based on CIMT and Non-invasive Neuromodulation Through C-tDCS on the Recovery of Paretic Upper Limb Function, Quality of Life, and Therapeutic Alliance in Women From the Araucanía Region Who Suffered a Stroke (CIMT + tDCS).","Effects of a Neurorehabilitation Program Based on Constraint-Induced Movement Therapy (CIMT) and Non-invasive Neuromodulation Through Cerebellar Transcranial Direct Current Stimulation (C-tDCS) on the Recovery of Paretic Upper Limb Function, Quality of Life, and Therapeutic Alliance in Women From the Araucanía Region Who Suffered a Stroke.","(CIMT - tDCS)","Inclusion Criteria:\n\n* Women aged between 30 and 80 years.\n* Who present hemorrhagic or ischemic stroke confirmed by CT with evolution greater than 1 month, corroborated by discharge epicrisis supporting the diagnosis of the patient.\n* Who presents trunk control in sitting.\n* Score greater than 14 points on the Minimental Examination scale.\n* Function of the upper extremity, referring to taking and releasing a small ball with the affected hand and signing or accepting the consent written informed.\n\nExclusion Criteria:\n\n* Shoulder pain greater than 4 according to the VAS scale and spasticity greater than 2 according to the Modified Ashworth Scale.\n* Sensory compromise (visual-auditory).\n* Presence of severe aphasia.\n* Cochlear implants, aneurysm clips, brain electrodes and cardiac pacemaker.\n* Epilepsy or psychiatric disorders (diagnosed in the last 3 months).\n* Pregnancy, use of psychotropic medications.","30 Years","85 Years",{"count":90,"type":21},24,[24],"General Objective To determine the effects of a neurorehabilitation program based on Constraint-Induced Movement Therapy (CIMT) and non-invasive neuromodulation through cerebellar transcranial direct current stimulation (C-tDCS) on the recovery of paretic upper limb function, quality of life, and therapeutic alliance in women from the Araucanía Region who suffered a stroke. Methodology An experimental design consisting of a single-blind randomized controlled clinical trial is proposed. The study will include two independent groups of women diagnosed with stroke, who will participate in five assessment time points (pre-treatment, intermediate, post-treatment, and two follow-ups). Motor function (Motor Activity Log-30 and ARAT), quality of life (ECVI-38), and therapeutic alliance (CAF-P) will be evaluated. The intervention includes 10 sessions (120 minutes each), delivered daily over a two-week period. The experimental group (EG) will receive CIMT combined with C-tDCS, while the control group (CG) will receive CIMT plus sham C-tDCS (using the standard safety sham protocol commonly known as \"FISSFO\" \\[Fade In of Stimulation, Brief Real Stimulation, Fade Out\\]). In both groups, C-tDCS will be applied during the first 20 minutes of the session simultaneously with the practice of specific upper-limb motor tasks, followed by 100 minutes of CIMT. The CG will receive the same intervention but with sham stimulation, applying current for one minute to generate the initial sensation without producing a physiological effect. Sessions will be conducted in mixed subgroups (two participants from the EG and two from the CG) sharing the same therapeutic space. A proposed sample size of N = 26 (13 patients per group) was calculated considering a statistical power of 80%, assuming a medium effect size of f = 0.25, an error probability α = 0.05, a power (1 - error probability β) = 0.95, and correlations among repeated measures = 0.50. An additional 10% was included to compensate for potential losses during follow-up. Simple random allocation of the sample will be performed using SPSS Statistics 27. Proposed Analysis Plan SPSS Statistics 27 software will be used. Initially, descriptive statistics will be employed to analyze the sample according to sociodemographic and clinical characteristics. Subsequently, Cronbach's alpha reliability coefficient will be calculated to examine the internal consistency of the motor function and quality-of-life variables, both within and between groups and across evaluation time points. The effects of the intervention will be assessed using unifactorial intragroup and intergroup analyses of covariance (ANCOVA). In each ANCOVA, treatment will be considered the independent variable, each motor function and quality-of-life score will be considered the dependent variable, and control variables will be included as covariates. All results with p-values less than or equal to 0.05 in one-tailed tests will be considered statistically significant. Expected Results It is expected that the combination of CIMT and C-tDCS will significantly enhance motor recovery in post-stroke women. The intervention may improve upper-limb function recovery, promote better quality of life, and optimize the therapeutic alliance, resulting in greater participation in daily activities. By modulating cerebellar activity, C-tDCS may facilitate neuronal plasticity and accelerate the response to intensive training. If confirmed, the study will provide evidence for a safe, accessible, and effective neurorehabilitation strategy, opening future low-cost avenues for current rehabilitation practices.",[94],"Stroke",[96,94,97,98],"upper limb","CIMT","tDCS","2026-06-01",{"date":101,"type":38},"2026-06-03",{"date":103,"type":38},"2026-03-01",{"date":105,"type":21},"2026-12-31",{"name":44,"class":45},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":4,"enrollmentInfo":115,"targetDuration":117,"studyType":118,"phases":4,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":46},"100632067","sustainable-anesthesia-in-myocardial-revascularization-surgery-100632067","NCT07508865","Sustainable Anesthesia in Myocardial Revascularization Surgery.","Sustainable Anesthesia in Myocardial Revascularization Surgery: a Non-randomized Interventional Study","Inclusion Criteria:\n\n1. Patients with coronary artery disease scheduled for coronary artery bypass graft surgery at Dr. Hernán Henríquez Aravena Hospital in Temuco.\n2. Competent patients over 18 years of age, meaning they can easily understand the informed consent process and the characteristics of the study.\n3. Elective interventions.\n\nExclusion Criteria:\n\n1. Interventions combined with other procedures or surgeries.\n2. Reoperations or second cardiac or thoracic surgical interventions.","18 Years",{"count":116,"type":21},116,"1 Day","OBSERVATIONAL","* Introduction: Greenhouse gases threaten the health and safety of humanity. The Declaration of Helsinki seeks to protect human health and emphasizes the urgency of implementing sustainable strategies. Sustainability is defined by three pillars: economic (costs), social (clinical effectiveness), and environmental (environmental impact). Clinical effectiveness in cardiac surgery has a new paradigm: \"optimized recovery,\" which translates into fewer complications, earlier extubation, shorter ICU stays, and potential cost reductions. The objective of this study is to compare the sustainability of the optimized recovery anesthetic technique with standard anesthetic practice in coronary artery bypass graft surgery, using a non-randomized interventional study design.\n* Methods: Patients aged 18 years or older with coronary artery disease scheduled for elective coronary artery bypass graft surgery will be recruited. Combined procedures and reinterventions will be excluded. Sample size: The optimized recovery group is expected to reduce postoperative mechanical ventilation by two hours. With a 95% confidence interval, 80% power, and a 1:3 ratio between the groups, a sample size of 29 and 87 patients was estimated for the optimized recovery and standard anesthesia groups, respectively.\n* The optimized recovery technique includes, preoperatively, oral pregabalin 75 mg, fasting, no benzodiazepines, total intravenous anesthesia, low-dose intravenous fentanyl, methadone 0.1-0.2 mg\u002Fkg IV, erector spinae plane block with 0.25% bupivacaine (20 mL per side), and postoperative nausea and vomiting prophylaxis with dexamethasone. Postoperatively, administer paracetamol 1 g IV every 6 hours, NSAIDs, and methadone 1 mg IV as needed. The standard anesthetic technique involves the anesthesiologist administering anesthesia as they have routinely done prior to the study, without changes.\n* Four anesthesiologists will participate in the study. Only one anesthesiologist will perform the OR technique, and their results will be compared with those of the other three, who will use their standard anesthetic technique. Patient assignment is independent, based on the hospital's schedule.\n* Analysis: The clinical effectiveness of each technique will be evaluated based on ICU extubation time. An economic analysis will be conducted based on average costs, and critical environmental impacts will be estimated through a life-cycle assessment.\n* Outcome: The performance of the indicator \"Costs in Euros\u002FCO2e\u002FExtubation Time\" will be studied. These will contribute to the estimation of an anesthetic strategy that addresses the challenges of sustainable medicine, reduces emissions, and enables the rational use of resources and their associated costs, offering environmentally friendly and clinically effective health solutions.",[121,122,123],"Coronary Artery Bypass","Anesthesia","Sustainability",[125,126,127,128,129],"sustainability","myocardial revascularization surgery","Enhanced recovery after surgery","life cycle assessment","cost effectiveness","2026-03-30",{"date":132,"type":38},"2026-04-02",{"date":134,"type":38},"2024-07-02",{"date":136,"type":21},"2026-05-30",{"name":44,"class":45},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":155,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":46},"100576567","effectiveness-and-acceptability-of-sdf-compared-to-art-for-the-management-of-early-childhood-caries-100576567","NCT06786975","Effectiveness and Acceptability of SDF Compared to ART for the Management of Early Childhood Caries","EFFECTIVENESS, ACCEPTABILITY AND ORAL HEALTH-RELATED QUALITY OF LIFE OF SILVER DIAMINE FLUORIDE COMPARED TO ATRAUMATIC RESTORATIVE TREATMENT FOR THE MANAGEMENT OF EARLY CHILDHOOD CARIES: PROTOCOL OF A PRAGMATIC RANDOMIZED CLINICAL TRIAL","SDF and ART","Inclusion Criteria:\n\n* Children belonging to INTEGRA or JUNJI kindergarten, from 2 years up to 5 years and 11 months with informed consent signed by parents and assent from the child.\n* Children with at least one active cavitated caries lesion, extended in dentin with no signs of pulp involvement and diagnosed with ICDAS code 5.\n\nExclusion Criteria:\n\n* Children with underlying systemic disease or disability\n* Children with known allergies to dental materials used\n* Children with transitory residence\n* Children with severe alterations of the dental estructure","24 Months","71 Months",{"count":149,"type":21},156,[24],"The goal of this clinical trial is to assess the acceptability and clinical effectiveness of Silver Diamine Fluoride (SDF) in comparison with Atraumatic Restorative Treatment (ART) in Early Childhood Caries (ECC) management at the community level. The main question it aims to answer are:\n\n• It's SDF more accepted and effective than ART in early childhood caries management when implemented at the community level?\n\nParticipants will be diagnosed by an experienced and calibrated dentist using the International Caries Detection and Assessment System (ICDAS), then children with decayed teeth will be treated with SDF (experimental) or ART (control); another operator will choose randomly the treatment for each participant. Furthermore, oral health education component will be given to children, parents and educators.\n\nFollow-up visits will be made at 6 and 12 months after child's treatment is complete. Before and after treatment parents will be asked to complete a child personal background survey (before), Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire (before and at follow-ups) and a oral health satisfaction survey (one week after treatment and at follow-ups). The acceptability will be assessed through quantitative and qualitative methods.\n\nResearchers will compare the SDF's groups and the ART's group to see which of them is more accepted and effective.",[153,154],"Early Childhood Caries","Health Care Acceptability",[153,156,157],"Silver Diamine Fluoride","Atraumatic Restorative Treatment","2025-12-04",{"date":160,"type":38},"2025-12-12",{"date":162,"type":21},"2025-12-15",{"date":164,"type":21},"2027-02-28",{"name":44,"class":45},{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":55,"sex":17,"minAge":174,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":183,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":78},"100604644","effects-of-resistance-exercises-in-hereditary-sensory-motor-neuropathy-charcot-marie-tooth-disease-100604644","NCT07152197","Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease)","Effects of a Resistance Exercise Training Program on Skeletal Muscle Quality, Functional Capacity, and Quality of Life in Young Individuals With and Without Hereditary Sensorimotor Polyneuropathy","PNP","Inclusion Criteria:\n\n* Men or women between 15 and 29 years of age with a diagnosis of hereditary sensorimotor polyneuropathy (HSPN) in any of its subtypes, living in the community (for experimental group).\n* Healthy men or women between 15 and 29 years of age living in the community (for control group).\n* Having active ankle movement within a range from plantarflexion to at least 0° of ankle dorsiflexion, allowing for strength training.\n\nExclusion Criteria:\n\n* Osteoarticular or mobility impairments that prevent safe performance of resistance exercise training (e.g., ankle arthrodesis).\n* Use of nutritional supplements that may affect skeletal muscle regulation (leucine, glutamine, casein, whey protein, fatty acids, creatine, among others).\n* Untreated and\u002For uncontrolled chronic diseases or intellectual disability.\n* History of surgery\n* Participation in a resistance exercise training program within the past 6 months.","15 Years","29 Years",{"count":177,"type":21},22,[24],"The goal of this clinical trial is to compare the effects of an 8-week resistance exercise training program on skeletal muscle quality, functional capacity, and quality of life in young individuals aged 15 to 29 years, with and without Hereditary Sensorimotor Polyneuropathy (HSPN).\n\nThe main questions to answer are:\n\nWhat is the effect of an 8-week resistance exercise training program on skeletal muscle quality, functional capacity, and quality of life in young individuals with and without HSPN?\n\nWill the percentage of improvement after the program be greater in participants with HSPN compared to those without, due to greater baseline alterations?\n\nResearchers will compare the resistance exercise training program with baseline conditions to determine its effectiveness in improving skeletal muscle quality, functional capacity, and quality of life.\n\nParticipants will undergo a supervised lower-limb resistance exercise program (3x\u002Fweek) for 8 weeks. The intervention will include progressive loads from 60% to 80% of 1-Repetition Maximum (1RM), with exercises targeting the major lower limb muscle groups. All participants will complete pre- and post-intervention evaluations, including ultrasound assessment of muscle architecture, functional capacity tests, strength measurements, body composition analysis, and quality of life questionnaires.",[181,182],"Polyneuropathy","Charcot Marie Tooth Disease (CMT)",[182,65,184,185],"Muscle Quality","Quality of Life","2025-09-21",{"date":188,"type":38},"2025-09-23",{"date":190,"type":38},"2025-09-20",{"date":192,"type":21},"2026-09-20",{"name":44,"class":45},{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":17,"minAge":202,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":22,"phases":205,"briefSummary":206,"conditions":207,"keywords":211,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":223,"locationsCount":46},"100602782","neuromuscular-electrical-stimulation-in-critically-ill-patients-aged-80-and-over-100602782","NCT07127991","Neuromuscular Electrical Stimulation in Critically Ill Patients Aged 80 and Over","Impact of Neuromuscular Electrical Stimulation on Muscle Mass, Strength, and Functionality in Critically Ill Oldest Old Patients: a Randomized Controlled Trial","NMES-ICU80","Inclusion Criteria:\n\n* People aged 80 years or older.\n* Hospitalized in the Adult Critical Care Unit of Dr. Hernán Henríquez Aravena Hospital in Temuco.\n* Estimated mechanical ventilation time greater than 72 hours.\n\nExclusion Criteria:\n\n* Patients with prior neurological complications.\n* Patients with severe dependence prior to admission.\n* Patients with difficult-to-manage hemodynamic instability.\n* Patients with accessory elements that limit assessment.\n* Patients with lower limb amputation.\n* Patients in the prone position.\n* Patients with loss of skin integrity.\n* Patients expected to remain in the unit for less than 72 hours.\n\nPatients transferred from other services with a stay of more than 72 hours.","80 Years",{"count":204,"type":21},30,[24],"The aim of this clinical trial is to evaluate the effectiveness of Medium-Frequency Neuromuscular Electrical Stimulation, in combination with standard physical therapy, compared to standard physical therapy alone, on muscle mass, muscle strength, and functionality in critically ill patients aged 80 and over during their hospital stay. The safety of the intervention and the standardization of protocol parameters will also be assessed.\n\nThe main research questions are:\n\n* Does the implementation of a standardized Medium-Frequency Neuromuscular Electrical Stimulation protocol, in combination with standard physical therapy, compared to standard physical therapy alone, help attenuate the loss of skeletal muscle mass, strength, and functionality in critically ill patients aged 80 and over?\n* Is the use of this protocol and its proposed parameters safe for critically ill patients aged 80 and over? The study will consist of applying a standardized Medium-Frequency Neuromuscular Electrical Stimulation protocol to oldest old patients admitted to the Intensive Care Unit of Dr. Hernán Henríquez Aravena Hospital in Temuco, Chile. The sample will consist of oldest old participants (≥80 years), who will be randomly divided into two subgroups: a control group that will receive standard physical therapy typically provided during hospitalization, and an experimental group that will receive the same standard therapy plus Medium-Frequency Neuromuscular Electrical Stimulation, which will begin within the first 48 hours of Intensive Care Unit admission.\n\nThe following variables will be assessed in both groups (control and experimental), from Intensive Care Unit admission to hospital discharge:\n\n* Skeletal muscle mass characteristics and evolution (quadriceps femoris and anterior tibialis muscle thickness), measured by ultrasonography.\n* Handgrip strength, measured using a digital hand dynamometer.\n* Inspiratory muscle strength, assessed using a pimometer.\n* Peripheral muscle strength, evaluated with the Medical Research Council Sum Score (MRC-SS).\n* Functionality, assessed by the Functional Status Score for the Intensive Care Unit (FSS-ICU) .\n* Independence in basic activities of daily living, measured using the Barthel Index.\n* Quality of life, evaluated using the Short Form-36 Health Survey (SF-36).\n* Cognitive impairment, assessed through the Montreal Cognitive Assessment (MoCA).\n* Frailty, measured using the Clinical Frailty Scale (CFS).",[208,209,210],"Intensive Care Units (ICUs)","Muscle Atrophy or Weakness","Old and Very Old People",[212,213,214,215,216],"MUSCLE ATROPHY","FUNCTIONAL STATUS","ICU","OLDER ADULTS","NMES","2025-08-13",{"date":219,"type":38},"2025-08-17",{"date":221,"type":21},"2025-09",{"date":76,"type":21},{"name":44,"class":45},{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":4,"enrollmentInfo":232,"targetDuration":4,"studyType":22,"phases":233,"briefSummary":234,"conditions":235,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":78},"100527462","manual-therapy-on-oral-opening-swallow-function-and-upper-quarter-mobility-on-head-and-neck-cancer-survivors-100527462","NCT06148077","Manual Therapy on Oral Opening, Swallow Function and Upper Quarter Mobility on Head and Neck Cancer Survivors","Effects of Manual Therapy on Oral Opening, Swallow Function, and Upper Quarter Mobility in Chilean Survivors of Head and Neck Cancer: A Study Protocol for a Controlled, Randomized Study (MATEO Study, MAnual ThErapy for Oral Opening).","MaTeO","Inclusion Criteria:\n\n* individuals with HNC\n* individuals over 18 years of age\n* individuals who have undergone oncological surgery of the head and neck and\u002For radiotherapy\n* having finished oncological medical treatment between 3 and 36 months before inclusion\n* having a medical diagnosis of trismus and\u002For TMD and\u002For cervical or shoulder dysfunction\n* Spanish native speakers\n\nExclusion Criteria:\n\n* sequelae of previous stroke\n* structural instability and\u002For osteoporosis of the cervical spine, spondylosis, cervical herniated discs\n* active osteoradionecrosis or open wounds (fistulas, soft tissue necrosis) in the anatomical treatment area\n* tracheostomized individuals\n* metastasis or active cancer\n* refuse to participate.",{"count":20,"type":21},[24],"Trismus has been reported as the second most common comorbidity in survivors of head and neck cancer (HNC). It is mainly associated with post-radiotherapy subcutaneous fibrosis, muscular atrophy, damage to neurological structures in the neck, or a combination of all, affecting masticatory musculature. In addition to this, the loss of flexibility and strength in the shoulder has also been shown to be related to deficits in the function and quality of life of these patients.\n\nThe goal of this clinical trial is to determinate the effectiveness and safety of Manual Therapy (MT) on Oral Opening, Swallow Function, as well as the mobility of the upper quarter, the strength of cervical musculature, pain, functionality, and the perception of quality of life in head and neck cancer survivors.\n\nParticipants will be assigned randomly to the study groups: a) manual therapy program and control motor exercises and b) motor control exercises (usual care).\n\nThe assessment refers to a baseline form (at the beginning of the study), at 6 weeks and at 6 weeks of patient follow-up.",[236,237,238],"Head and Neck Cancer","Trismus","Dysfunction","2025-05-23",{"date":241,"type":38},"2025-05-30",{"date":243,"type":38},"2024-09-25",{"date":245,"type":21},"2025-10-01",{"name":44,"class":45},{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":253,"eligibilityCriteria":254,"healthyVolunteers":55,"sex":56,"minAge":18,"maxAge":255,"enrollmentInfo":256,"targetDuration":4,"studyType":22,"phases":258,"briefSummary":259,"conditions":260,"keywords":263,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":78},"100544316","resistance-exercise-training-in-the-older-population-with-obesity-100544316","NCT06367296","Resistance Exercise Training in the Older Population With Obesity","Effects of a Resistance Exercise Training Program on Skeletal Muscle Quality, Immune Response and Physical Performance in Normal Weight Versus Obesity Older Women","RETOPO","Inclusion Criteria:\n\n* Older women between 60 and 79 years old who live in the community, that is, they do not live in nursing homes or similar.\n* Older people with normal weight (BMI=18.5 to 24.9 kg\u002Fm2 and % fat \\\u003C25.9) and those with obesity (BMI= 30 to 39.9 Kg\u002Fm2 and % fat \\> 32).\n* Cognitive ability to follow verbal orders.\n\nExclusion Criteria:\n\n* Neuromuscular or mobility disorders that do not allow resistance training to be carried out safely (debilitating arthritis, spasticity\u002Frigidity, neurological disorders and paralysis).\n* Use of nutritional supplementation that can regulate skeletal muscle (leucine, glutamine, casein, whey-protein, fatty acids and creatine).\n* Untreated and\u002For uncontrolled chronic diseases.\n* Have carried out a training program with resistance exercises in the last 6 months.","79 Years",{"count":257,"type":21},32,[24],"Background:\n\nAging leads to an alteration in the immune response, characterized by a chronic inflammatory state, and a progressive decrease in muscle quantity and quality, a situation that increases in women and in the presence of obesity. With respect to muscle quality, intramuscular infiltration of adipose tissue has been considered a relevant parameter, involved in the relationship between aging-obesity-inflammation. As a therapeutic strategy, physical training with resistance exercises (or also known as strength training) has been shown to be effective in increasing skeletal muscle mass in this age group. However, its role on muscle quality in normal-weight versus obese older women has not been fully addressed.\n\nHypothesis:\n\nA 12-week resistance exercise training program is effective in improving muscle quality, immune response and physical performance in normal weight and obese older women. In addition to the above, the investigators hypothesize that women with obesity will present greater baseline alterations, so the percentage of change will be higher compared to older women with normal weight after the training program.\n\nGoals:\n\nThe primary aim of this study is to evaluate the effects of a 12-week resistance exercise training on muscle quality (infiltration of intramuscular adipose tissue), immune response and physical performance in older women between 60 and 79 years of age with obesity compared to older women with normal weight of the same age range.\n\nMethodology:\n\nThe present clinical trial will consider 2 groups of older women between 60 and 79 years old: normal weight (BMI=18.5 to 24.9 kg\u002Fm 2 and % fat \\\u003C25.9) and obese (BMI =30 to 39.9 Kg\u002Fm 2 and fat % \\>32). Participants will perform 12 weeks of training with resistance exercises 3 times a week. Before and after training, intramuscular infiltration of adipose tissue (echogenicity) will be measured by ultrasound, followed by aspects of muscle architecture (muscle thickness, penile angle and fascicle length) and functional parameters of muscle quality (maximum strength determined by 1 repetition maximum-1RM, maximum voluntary isometric strength of knee extensors through a lower limb force and power transducer). Finally, fasting blood samples will be obtained (immune response) and physical performance, body composition, physical activity level, and quality of life will be evaluated.",[261,262],"Aging","Obesity",[264,265,266,267],"Strength training","Malnutrition due to excess","Biochemical markers","Clinical anatomy","2025-01-22",{"date":270,"type":38},"2025-01-27",{"date":272,"type":38},"2024-07-01",{"date":274,"type":21},"2025-06-01",{"name":44,"class":45},{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":282,"eligibilityCriteria":283,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":4,"enrollmentInfo":284,"targetDuration":4,"studyType":22,"phases":286,"briefSummary":287,"conditions":288,"keywords":291,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":303},"100540195","comprehensive-hybrid-cardiac-rehabilitation-trial-on-heart-failure-100540195","NCT06313684","Comprehensive Hybrid Cardiac Rehabilitation Trial on Heart Failure","Comprehensive Hybrid Cardiac Rehabilitation Trial to Assess Impact on Heart Failure Patients","COCREATIONHF","Inclusion Criteria:\n\n* Adult patients with HF of New York Heart Association functional class II or III.\n* Meets HF diagnostic criteria of Guidelines\n* On optimal tolerated medical therapy.\n* Deemed by the treating physician as stable for at least 1 month.\n* Able to attend the health center three times a week for the first month, and twice a week for the 2nd and 3rd months\n* Owns a mobile phone\n* Patient consents to participate in the study by signing an informed consent form.\n\nExclusion Criteria:\n\n* Chronic kidney disease with glomerular filtration rate \\\u003C 20 mL\u002Fmin.\n* Decompensated thyroid disease.\n* End-stage liver failure or Child-Pugh C.\n* Cardiac device or cardiac surgery in the previous month or planned in the next 3 months.\n* Patients with dyspnea predominantly of non-cardiac cause (e.g. COPD).\n* Atrial fibrillation with a heart rate greater than 90 beats per minute at rest.\n* Active neoplasm with life expectancy \\\u003C2 years.\n* Inclusion in another interventional study.\n* Explicit contraindications to performing exercise.\n* Comorbidities that preclude the patient from engaging in a CR program.\n* Musculoskeletal or neurological disease that precludes the patient from performing exercise.",{"count":285,"type":21},152,[24],"CO-CREATION-HF aims to evaluate the effectiveness of a comprehensive and hybrid cardiac rehabilitation model compared to supervised exercise alone.",[289,290],"Heart Failure NYHA Class II","Heart Failure NYHA Class III",[292,293,294],"cardiac rehabilitation","heart failure","exercise","2024-11-27",{"date":297,"type":38},"2024-12-03",{"date":299,"type":38},"2024-04-01",{"date":301,"type":21},"2027-03",{"name":44,"class":45},4,""]