[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidade Estadual Paulista Júlio de Mesquita Filho\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":181},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,47,75,100,124,152],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100603071","effect-of-heated-water-based-versus-land-based-exercise-training-on-hemodynamic-variables-functional-capacity-and-quality-of-life-in-older-hypertensive-100603071",false,"NCT07131748","Effect of Heated Water-Based Versus Land-Based Exercise Training on Hemodynamic Variables, Functional Capacity and Quality of Life in Older Hypertensive","Effect of Heated Water-Based Versus Land-Based Exercise Training on Hemodynamic Variables, Functional Capacity and Quality of Life in Older","HExOLD","Inclusion Criteria:\n\n\\- For the study population, the following will not be included in the study:\n\n* Smokers (avoiding acute effects of smoking on physiological measures);\n* Individuals with decompensated cardiovascular disease, thyroid dysfunction and \u002F or inflammatory diseases;\n* Unable individuals to perform an exercise program or ergospirometric test due to physical or mental incapacity;\n* Individuals with hemodynamic and \u002F or electrocardiographic changes during the ergospirometric test.\n* Only individuals older than 60 years, with a diagnosis of SAH for more than 6 months (stage 1 or 2), using antihypertensive medication (office BP less than 140\u002F90 mmHg) and without medication change for at least 2 months.\n\nExclusion Criteria:\n\n* For the study population, individuals who have less than 60% adherence to scheduled physical exercise sessions will be excluded during the study.\n* Individuals who change or discontinue their clinical and \u002F or pharmacological treatment (with or without a prescription).","ALL","60 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","BACKGROUND: Physical exercise promotion is one of the main global goals of innumerous health and medical societies for preventing and managing noncommunicable chronic diseases (NCDs), being one of the main therapeutic for the patient with hypertension. Exercise in heated swimming pool has emerged as a potential alternative to physical exercise on the ground for the reduction of blood pressure (BP) of hypertensive patients, however, its effects on BP, as well as hemodynamic, metabolic, inflammatory and functional variables of older individuals with hypertension have not been investigated.\n\nPURPOSE: To evaluate the effects of heated water-based exercise (HEx) versus land-based exercise (LEx) on BP, arterial stiffness, endothelial function, metabolic, inflammatory and functional variables of older individuals with hypertension.\n\nMETHODS: 60 older individuals (male and female) with hypertension (age \\> 60 years) will be randomized in 2:2:1 ratio to HEx, LEx or control (CON) intervention. The feasibility and physiological adaptations (physical capacity, musculoskeletal and cardiovascular responses to stress, biological and biochemical markers associated with the pathophysiology of the disease and vascular adaptations) will be assessed before, after 12 weeks and after 24 weeks of follow-up. HEx and LEx training programs will be performed three times per week and will be performed for the firs 12 weeks of follow-up.",[27,28,29],"Hypertension","Aging","Exercise",[28,29,31,27,32,33],"Pathophysiology","Elderly","Hemodynamic Response","RECRUITING","2025-08-12",{"date":37,"type":38},"2025-08-20","ACTUAL",{"date":40,"type":21},"2025-09-01",{"date":42,"type":21},"2027-08-30",{"name":44,"class":45},"Universidade Estadual Paulista Júlio de Mesquita Filho","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100603072","effect-of-tai-chi-versus-moderate-intensity-combined-exercise-training-on-cardiovascular-health-and-physical-functional-performance-in-older-men-and-women-with-t2dm-the-tai-chi-intervention-for-diabetes-management-during-aging-tida-study-100603072","NCT07131761","Effect of Tai Chi Versus Moderate-intensity Combined Exercise Training on Cardiovascular Health and Physical Functional Performance in Older Men and Women With T2DM: the Tai Chi Intervention for Diabetes Management During Aging (TIDA) Study","Effect of Tai Chi Versus Moderate-intensity Combined Exercise Training on Cardiovascular Health and Physical Functional Performance in Older Men and Women With T2DM","TIDA","Inclusion Criteria:\n\nonly with type 2 diabetes\n\nExclusion Criteria:\n\n* if not able to perform physical exercise (Extreme neuropathy, wounds in the feet, and amputation risk.)","65 Years",{"count":57,"type":21},66,[24],"This randomized, single-blind, controlled clinical trial compares the effects of a 12-week Tai Chi program versus moderate-intensity combined exercise (MICE) training on cardiovascular health, glycemic control, and physical function in older adults with type 2 diabetes (T2DM). Sixty-six participants (33 men and 33 women) will be randomized 1:1:1 to Tai Chi (n = 22), MICE (n = 22), or a non-exercise control group (CON, n = 22).\n\nThe Tai Chi intervention involves three weekly Yang-style sessions, progressively increasing in duration and complexity while maintaining perceived exertion (PSE) below 12 (6-20 scale). The MICE program combines moderate-intensity walking (PSE 12-13) with six strengthening exercises (PSE 12-14), gradually increasing from 15 to 30 minutes\u002Fsession and 1 to 3 sets over 12 weeks.\n\nPrimary outcomes include cardiovascular health (Life's Essential 8 index: diet, physical activity, nicotine exposure, sleep, BMI, lipids, blood glucose, and blood pressure) and glycemic control (fasting glucose, HbA1c). Secondary outcomes assess physiological mechanisms (heart rate variability, pulse wave velocity, flow-mediated dilation, carotid intima-media thickness), physical performance (6-minute walk test, grip strength, timed up-and-go), and quality of life (WHOQOL-BREF\u002FOLD).\n\nAll evaluations will be conducted by blinded assessors under standardized conditions (21-24°C, morning fasting), except the 6MWT. Statistical analysis includes intention-to-treat repeated-measures ANOVA, ANCOVA for baseline adjustments, and per-protocol\u002Fadherence-adjusted analyses. Sample size (GPower) was calculated to detect a 0.8% HbA1c reduction with 90% power (30% attrition accounted for). An interim analysis at 50% completion will evaluate effect sizes\u002Fvariability, with potential sample-size recalibration by an independent committee.\n\nThe study employs rigorous quality controls: standardized protocols, blinded assessments, and monitoring of confounders (medication changes, acute exercise effects). Ethical approval (CAAE: 88582225.1.0000.5398) ensures adherence to informed consent and privacy. By determining whether Tai Chi offers comparable or superior benefits to MICE for cardio metabolic health and functional capacity, this trial aims to inform evidence-based exercise prescriptions for older T2DM patients.",[61],"Type 2 Diabetes Mellitus (T2DM)",[63,64,65,66,67,68],"Diabetes","Type 2 Diabetes","Cardiovascular risk factor","Metabolic risk","Non communicable disease","Vascular aging","NOT_YET_RECRUITING",{"date":37,"type":38},{"date":37,"type":21},{"date":73,"type":21},"2025-12-25",{"name":44,"class":45},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":99,"locationsCount":4},"100601665","acute-effect-of-tai-chi-versus-moderate-intensity-combined-exercise-on-cardiovascular-metabolic-and-cardiac-autonomic-control-parameters-in-older-men-and-women-with-type-2-diabetes-mellitus-100601665","NCT07113444","Acute Effect of Tai Chi Versus Moderate-Intensity Combined Exercise on Cardiovascular, Metabolic, and Cardiac Autonomic Control Parameters in Older Men and Women With Type 2 Diabetes Mellitus","The Acute Effect of Tai Chi Versus Moderate-Intensity Combined Exercise on Cardiovascular, Metabolic, and Cardiac Autonomic Control Parameters in Older Men and Women With Type 2 Diabetes Mellitus: A Randomized, Single-Blind, Crossover Controlled Trial",{"count":82,"type":21},24,[24],"Type 2 diabetes mellitus (T2DM) in the elderly population is associated with compromised cardiovascular and metabolic functions, thereby necessitating the implementation of safe exercise interventions. This study employs a randomized, single-blind, crossover design will be conducted in Brazil to examine whether Tai Chi, a low-impact mind-body exercise, offers acute benefits comparable to those of moderate-intensity combined exercise (MICE) in 24 older adults (≥65 years) diagnosed with T2DM, consisting of 12 men and 12 women. Participants recruited through community advertisements and screened to ensure inactivity, stable medication usage, and the absence of significant comorbidities will undergo randomized sessions of Tai Chi, MICE, and a control (CON) intervention. Evaluations will include capillary blood glucose (the primary outcome), blood pressure, heart rate variability, arterial stiffness (PWVcf), and endothelial function (FMD) measured before, immediately after, and 45minute post-intervention, along with 24-hour ambulatory monitoring. Standardized protocols will be employed to regulate physical activity. By juxtaposing these interventions, the study seeks to ascertain if Tai Chi could serve as a feasible alternative for enhancing acute metabolic and cardiovascular responses in older diabetic adults, thus providing practical insights for clinical and lifestyle management.",[64],[87,88,89,90,91,92],"Tai Ji","Diabetes Mellitus, Type 2","Blood Glucose","Cross-Over Studies","Vascular Stiffness","Endothelium, Vascular","2025-08-07",{"date":95,"type":38},"2025-08-08",{"date":37,"type":21},{"date":98,"type":21},"2025-11-20",{"name":44,"class":45},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":15,"eligibilityCriteria":106,"healthyVolunteers":107,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":112,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":46},"100372237","high-intensity-interval-versus-moderate-intensity-continuous-water-based-exercise-in-hypertensive-older-individuals-100372237","NCT04126785","High-Intensity Interval Versus Moderate-Intensity Continuous Water Based Exercise in Hypertensive Older Individuals","Effects of High-Intensity Interval Versus Moderate-Intensity Continuous Heated Water-Based Exercise on Blood Pressure and Hemodynamic Variables in Older Individuals With Hypertension","Inclusion Criteria:\n\n* ≥60 years old;\n* Hypertension diagnosed at least 6 months earlier (stage 1 or 2);\n* Antihypertensive drug treatment and without dosage alteration at least 3 months earlier;\n* Blood pressure inferior to 140\u002F90 mmHg in medical office.\n\nNon-inclusion criteria:\n\n* Smoking individuals;\n* Uncontrolled cardiovascular disease;\n* Disability;\n* Deficit cognitive;\n\nExclusion Criteria:\n\n* Non 100% participation;\n* Change (or stopped) clinical or drug treatment.",true,{"count":20,"type":21},[24],"This study will investigate the acute and chronic effects in hemodynamic and autonomic variables to high-intensity interval versus moderate-intensity continuous heated water-based exercise in older individuals with hypertension.",[27],[28,113,114,29,115],"Blood Pressure","Endothelial function","Heart rate variability","2025-07-22",{"date":118,"type":38},"2025-07-25",{"date":120,"type":38},"2019-11-01",{"date":122,"type":21},"2026-12",{"name":44,"class":45},{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":107,"sex":17,"minAge":131,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":135,"phases":4,"briefSummary":136,"conditions":137,"keywords":140,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":46},"100535156","relationship-of-lifestyle-habits-and-health-characteristics-of-parents-and-children-100535156","NCT06248164","Relationship of Lifestyle Habits and Health Characteristics of Parents and Children","Relationship of Lifestyle Habits and Health Characteristics of Parents and Children: An Epidemiological Study","Inclusion Criteria:\n\n* Children and adolescent over 6 years old.\n\nExclusion Criteria:\n\n\\-","6 Years","89 Years",{"count":134,"type":21},176,"OBSERVATIONAL","Lifestyle habits and health characteristics (e.g., excess weight) acquired in childhood and adolescence have a good chance of being carried into adulthood. In this sense, seeking to understand which factors can influence these habits and\u002For characteristics is of paramount importance. One of these factors that can influence the health of children and adolescents are the lifestyle habits and characteristics of these young people's parents. One of the lifestyle habits that appears to be related between parents and children is physical activity. However, most studies analyze the practice of physical activity between parents and children only considering the practice of total physical activity, that is, not considering the different domains of physical activity \\[ i) physical efforts carried out in the work environment, occupations in the case of adults and in the school environment in the case of children and adolescents; ii) physical activities carried out during leisure time; iii) physical activities carried out in the form of active commuting\\], in addition to there being little information considering the different intensities of physical activity (light, moderate, vigorous and very vigorous). Another gap to be addressed is the relationship between other health variables between parents and children, including unhealthy lifestyle habits, such as smoking, eating disorders and symptoms of anxiety and depression, as well as adverse health conditions, such as the presence of chronic diseases. and overweight, would be different considering the parents' practice of physical activity, for example; whether the possible relationship between excess weight between parents and children would be similar in children of physically active parents when compared to children of insufficiently active parents. Therefore, the objective of the present study will be to verify whether the different domains and intensities of physical activity are related between parents and children, as well as to verify whether other lifestyle habits and health characteristics are related between parents and children, considering the levels of activity. physical status of parents (physically active and insufficiently active).",[138,139],"Adult Fathers and Mothers","Children and Adolescents, Boys and Girls",[141,142,143],"Family atmosphere","Lifestyle","Public health","2025-03-25",{"date":146,"type":38},"2025-03-26",{"date":148,"type":38},"2023-11-01",{"date":150,"type":21},"2025-12-31",{"name":44,"class":45},{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":107,"sex":17,"minAge":159,"maxAge":160,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":163,"briefSummary":164,"conditions":165,"keywords":168,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":180},"100557636","comparison-of-palatal-wound-healing-in-diabetic-and-non-diabetic-patients-100557636","NCT06540690","Comparison of Palatal Wound Healing in Diabetic and Non-diabetic Patients","Comparison of Palatal Wound Healing in Diabetic and Non-diabetic Patients: Controlled Clinical Trial and in Vitro Study","Inclusion Criteria:\n\n* Patients with at least 18 years, systemically healthy, with good oral hygiene, assessed by plaque index and gingival index less than 25% (Ainamo, Bay, 1975);\n* Patients with no morphological or pathological conditions on the palatine donor area;\n* Patients who present indication for extraction and ridge preservation;\n* The tooth included in the study, as well as, the adjacent teeth do not present loss of periodontal insertion;\n* Patients who agreed to and sign the formal consent to participate in the study after receiving an explanation of risks and benefits from an individual who was not a member of the present study (Resolution no. 118 - May, 2012, and Ethics and Code of Professional Conduct in Dentistry - 118\u002F12).\n* Patients diagnosed with type 2 diabetes for more than 5 years who are using oral hypoglycemic agents or insulin supplementation, with HbA1c levels ranging from ≥ 6.1% to 8.5%.\n* Non-diabetic patients with HbA1c levels below 6.1%.\n\nExclusion Criteria:\n\n* Patients with systemic problems (cardiovascular, blood dyscrasias, immunodeficiency, and diabetes, among others) that will contraindicate the surgical procedure;\n* Patients taking medications known to interfere with the wound healing process or that contraindicate the surgical procedure;\n* Smokers patients;\n* Pregnant or lactating patients;\n* Patients who had had periodontal surgery on the study area;\n* Patients who presents opportunistic oral lesions, mainly colonized the palate region;\n* Use of dental prosthesis with palatal cover;\n* Thin palatal mucosa (\\~2.0mm).","18 Years","80 Years",{"count":162,"type":21},50,[24],"This study aims to characterize and compare the closure of open wounds in the palatal mucosa of diabetic and non-diabetic patients, evaluate clinical, patient-centered and immunological parameters as well as wound microbiome composition.",[166,167,63],"Palate; Wound","Wound Heal",[169,170,171,63],"Periodontology","Wound healing","Controlled Clinical Trial","2024-08-02",{"date":174,"type":38},"2024-08-06",{"date":176,"type":38},"2023-08-01",{"date":178,"type":21},"2027-01-06",{"name":44,"class":45},2,""]