[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidade Federal de Pernambuco\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":414},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,41,76,101,130,152,180,202,227,245,279,306,332,374,393],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100641424","swallowing-assessment-for-predicting-extubation-failure-in-critically-ill-patients-100641424",false,"NCT07659275","Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients","Prospective Evaluation of the Prognostic Performance of an Orotracheal Tube-Adapted Swallowing Biomechanics Assessment for Predicting Extubation Failure in Critically Ill Patients","APEX","Inclusion Criteria:\n\n* Age ≥18 years.\n* Admission to an intensive care unit.\n* Invasive mechanical ventilation for ≥48 hours.\n* Successful completion of a spontaneous breathing trial according to local practice.\n* Ability to undergo bedside swallowing biomechanics assessment using the APEX score before extubation.\n* Written informed consent from the patient or legally authorized representative, when required by local regulations.\n\nExclusion Criteria:\n\n* Presence of a tracheostomy.\n* Decision to withhold or withdraw life-sustaining treatments.\n* Structural abnormalities of the upper airway or face precluding APEX assessment.\n* Conditions preventing assessment of swallowing biomechanics (e.g., maxillofacial trauma, recent head and neck surgery, or other conditions judged by the investigator to interfere with the evaluation).","ALL","18 Years",{"count":20,"type":21},800,"ESTIMATED","OBSERVATIONAL","Extubation failure, defined as the need for reintubation after planned removal of the endotracheal tube, occurs in up to 20% of critically ill patients and is associated with prolonged mechanical ventilation, longer intensive care unit (ICU) stay, and increased mortality. Current assessments of extubation readiness focus primarily on respiratory performance and do not routinely evaluate upper airway protective function.\n\nThe Airway Protection for Extubation (APEX) score is a bedside assessment tool based on swallowing biomechanics designed to evaluate airway protection before extubation. In a pilot prospective cohort study, the APEX score demonstrated promising performance for identifying patients at increased risk of extubation failure.\n\nThis prospective multicenter cohort study will be conducted across ICUs in Brazil to externally validate the APEX score in critically ill adults undergoing planned extubation. The study will evaluate the discrimination, calibration, and clinical utility of the APEX score for predicting extubation failure and will assess its performance across different patient populations and hospital settings.\n\nThe results of this study may support the incorporation of a simple bedside assessment of swallowing biomechanics into extubation readiness evaluation and contribute to more individualized decision-making regarding extubation in critically ill patients.",[25,26,27],"Extubation Failure","Mechanical Ventilation","Critical Illness","NOT_YET_RECRUITING","2026-06-15",{"date":31,"type":32},"2026-06-22","ACTUAL",{"date":34,"type":21},"2027-03-30",{"date":36,"type":21},"2030-10-30",{"name":38,"class":39},"Universidade Federal de Pernambuco","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":40},"100637199","hydrodissection-with-neuroprolotherapy-versus-open-release-for-carpal-tunnel-syndrome-100637199","NCT07576803","Hydrodissection With Neuroprolotherapy Versus Open Release for Carpal Tunnel Syndrome","Ultrasound-Guided Hydrodissection Combined With Neuroprolotherapy Versus Open Carpal Tunnel Release in Patients With Carpal Tunnel Syndrome: A Randomized, Parallel-Group, Non-Inferiority Trial","HN-CTS","Inclusion Criteria:\n\n* Adults aged 18 years or olde\n* Clinical diagnosis of carpal tunnel syndrome\n* Presence of symptoms for at least 3 months\n* Failure of conservative treatment, including splinting, medication, or physical therapy\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Previous carpal tunnel surgery in the affected limb\n* Severe thenar muscle atrophy\n* Cervical radiculopathy or proximal nerve compression\n* Pregnancy\n* Coagulopathy or current use of anticoagulants contraindicating procedures\n* Local infection at the intervention site\n* Inability to comply with follow-up","70 Years",{"count":51,"type":21},72,"INTERVENTIONAL",[54],"NA","This study is a randomized controlled, parallel-group, non-inferiority trial designed to compare ultrasound-guided hydrodissection combined with neuroprolotherapy versus open carpal tunnel release in patients with carpal tunnel syndrome. Participants will be randomly allocated in a 1:1 ratio using a computer-generated sequence, with allocation concealment ensured by sequentially numbered, sealed, opaque envelopes. Outcome assessment and statistical analysis will be performed by blinded evaluators.\n\nThe experimental group will undergo a single session of ultrasound-guided hydrodissection with perineural injection of a solution composed of zero point nine percent sodium chloride and five percent dextrose, combined with local anesthetic and betamethasone, aiming to promote mechanical release of the median nerve and modulation of the inflammatory process. The control group will undergo standard open carpal tunnel release through surgical division of the transverse carpal ligament under sterile conditions.\n\nParticipants will be assessed at baseline, and at 1, 3, and 6 months after intervention. The primary outcome is the change in the Boston Carpal Tunnel Questionnaire score at 3 months. A non-inferiority margin of 0.5 points will be adopted. Secondary outcomes include pain intensity measured by visual analog scale, grip strength, pinch strength, median nerve cross-sectional area assessed by ultrasound, time to return to work, and procedure-related complications.\n\nStatistical analysis will follow the intention-to-treat principle, with complementary per-protocol analysis. Between-group comparisons will be conducted using analysis of covariance adjusted for baseline values, and repeated measures will be analyzed using mixed-effects models. The hypothesis is that the minimally invasive intervention is non-inferior to surgical decompression, with potential advantages in recovery and morbidity.",[57,58],"Carpal Tunnel Syndrome","Median Neuropathy",[60,61,62,57,63,64,65,66,67],"Hydrodissection","Perineural injection","Ultrasound-guided procedure","Median nerve decompression","Minimally invasive treatment","Open carpal tunnel release","Nerve entrapment","Functional outcomes","2026-05-04",{"date":70,"type":32},"2026-05-08",{"date":72,"type":21},"2026-05-02",{"date":74,"type":21},"2027-08-31",{"name":38,"class":39},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":52,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":40},"100603092","efficacy-of-trans-auricular-vagus-nerve-stimulation-on-upper-extremity-motor-recovery-in-stroke-survivors-100603092","NCT07132021","Efficacy of Trans-auricular Vagus Nerve Stimulation on Upper Extremity Motor Recovery in Stroke Survivors","Inclusion Criteria:\n\nPatients aged between 18 and 75 years, with motor impairment in the upper extremity caused by unilateral ischemic or hemorrhagic stroke with stroke onset within the last five years.\n\nExclusion Criteria:\n\n* Patients with any contraindication to taVNS, peripheral upper extremity injuries, use of medication affecting cortical excitability in the past 3 months, use of botulinum toxin in the past 3 months, presence of any other neurological disorder, or significant cognitive deficits.","75 Years",{"count":84,"type":21},30,[54],"The aim of this clinical trial is to determine if trans-auricular vagus nerve stimulation (taVNS) is effective in improving upper extremity function in stroke survivors. The primary objectives include: Investigating whether taVNS improves motor function in stroke survivors. The secondary objectives include: Assessing any potential side effects associated with the method. Investigating taVNS effects on daily routine functions and spasticity Researchers will conduct a comparative analysis between taVNS and a sham procedure (which mimics the stimulation without any actual effect) to assess its effectiveness. Participants in the trial will: Undergo taVNS combined with physical therapy or a sham procedure with physical therapy daily over a two-week period.",[88],"Stroke",[90,91,92],"trans-auricular vagus nerve stimulation","stroke","upper extremity function","RECRUITING","2026-04-28",{"date":68,"type":32},{"date":97,"type":32},"2025-08-01",{"date":99,"type":21},"2026-12-01",{"name":38,"class":39},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":108,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":52,"phases":110,"briefSummary":111,"conditions":112,"keywords":117,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":40},"100630465","effects-of-the-stimulation-site-of-tsms-with-tms-on-functional-mobility-in-individuals-with-parkinsons-disease-100630465","NCT07488026","Effects of the Stimulation Site of tsMS With TMS on Functional Mobility in Individuals With Parkinson's Disease","Effects of the Stimulation Site of Trans-spinal Magnetic Stimulation Combined With Transcranial Magnetic Stimulation on Functional Mobility in Individuals With Parkinson's Disease","Inclusion Criteria: (i) a clinical diagnosis of Parkinson's disease confirmed by a neurologist; (ii) stable dopaminergic pharmacological treatment for at least three months; (iii) age 40 years or older; (iv) disease stage between 2.5 and 3 on the modified Hoehn and Yahr scale; (v) (v) gait impairment, defined as the occurrence of at least one freezing of gait episode per week.\n\n\\-\n\nExclusion Criteria:\n\n(i) other neurological disorders, orthostatic hypotension, vestibular, musculoskeletal, or visual impairments that could compromise performance on the proposed assessments; (ii) other osteomuscular conditions affecting the lower limbs that interfere with mobility and functional performance; (iii) a Montreal Cognitive Assessment (MoCA) score lower than 21 points; (iv) prior surgical procedures for Parkinson's disease; or (v) contraindications to magnetic stimulation techniques, including a history of seizures or the presence of metallic implants in the neck or spinal region.","40 Years",{"count":84,"type":21},[54],"This randomized clinical trial aims to compare the effects of two different trans-spinal magnetic stimulation (tsMS) application sites, cervical versus thoracic, when combined with repetitive transcranial magnetic stimulation (rTMS), on functional mobility in individuals with Parkinson's disease (PD). Participants diagnosed with PD will be randomized into two intervention groups (rTMS + cervical tsMS or rTMS + thoracic tsMS) and will undergo 10 treatment sessions. Outcomes will include functional mobility, gait speed, motor function, freeing of gait, balance, quality of life, global perceived improvement and adverse events. The study is expected to identify the most effective tsMS application site to enhance mobility and motor outcomes in PD, contributing to the optimization and standardization of tsMS protocols as an adjunct therapy.",[113,114,115,116],"Parkinson's Disease (PD)","Gait Disorders","Transcranial Magnetic Stimulation","Spinal Cord Stimulation",[118,119,120,121],"gait disorders","spinal cord stimulation","transcranial magnetic stimulation","parkinson's disease","2026-03-18",{"date":124,"type":32},"2026-03-23",{"date":126,"type":32},"2026-01-05",{"date":128,"type":21},"2026-12",{"name":38,"class":39},{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":17,"minAge":108,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":52,"phases":139,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":40},"100621114","phase-2-tavns-on-functional-mobility-in-people-with-dp-100621114","NCT07366411","taVNS on Functional Mobility in People With DP","Transcutaneous Auricular Vagus Nerve Stimulation on Functional Mobility in People With Parkinson's Disease","Inclusion Criteria:\n\n* clinical diagnosis of PD provided by a neurologist;\n* undergoing regular antiparkinsonian drug treatment (at least three months of regular and stable use);\n* aged 40 years or older;\n* with a Hoehn \\& Yahr stage of 2.5 to 4.\n\nExclusion Criteria:\n\n* other neurological disorders, postural hypotension, vestibular, musculoskeletal, or visual disorders that compromise performance in the proposed tests;\n* other osteomyoarticular diseases in the lower limbs that interfere with performance and locomotion;\n* Montreal Cognitive Assessment (MoCA) score lower than 21 points;\n* previous surgical procedure for PD.","80 Years",{"count":84,"type":21},[140],"PHASE2","Parkinson's disease (PD) is characterized by motor impairments such as bradykinesia accompanied by resting tremor and\u002For rigidity. As PD progresses due to its neurodegenerative nature, complementary strategies must be developed to optimize its effects. Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a strategy for controlling the symptoms of the disease. Nevertheless, the efficacy of this approach in managing PD remains to be elucidated. The objective of the present study is to investigate and compare the effects of transcutaneous vagus nerve stimulation (taVNS) and sham taVNS on functional mobility, which is the primary outcome and will be assessed using the Timed Up and Go test. The following tests will be used to evaluate the secondary outcomes: the miniBESTest and the Biodex Balance System (balance), the MDS-UPDRS and the Five-Time Sit-to-Stand Test (motor function), the FOG-Q (freezing of gait), the 10-Meter Walk Test (gait speed), the PGIC (perception of change), and the recording of adverse events. The volunteers will be divided into two groups: one group will receive taVNS in conjunction with physical therapy, while the other group will receive a sham taVNS in conjunction with physical therapy. To assess the effect of therapy, the efficacy of taVNS in enhancing the effects of physical therapy on the functional mobility of people with PD will be evaluated.",[143],"PARKINSON DISEASE (Disorder)","2026-01-16",{"date":146,"type":32},"2026-01-26",{"date":148,"type":21},"2026-02-15",{"date":150,"type":21},"2027-06-30",{"name":38,"class":39},{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":159,"targetDuration":4,"studyType":52,"phases":160,"briefSummary":161,"conditions":162,"keywords":166,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":179},"100598576","phase-2-efficacy-of-cerebello-spinal-direct-current-stimulation-csdcs-on-functional-mobility-in-chronic-stroke-patients-100598576","NCT07073287","Efficacy of Cerebello-spinal Direct Current Stimulation (csDCS) on Functional Mobility in Chronic Stroke Patients","Efficacy of Cerebello-spinal Direct Current Stimulation on Functional Mobility in Chronic Stroke Patients","Inclusion Criteria:\n\n* Confirmation of Stroke by digital or physical imaging or medical report\n* Gait impairment\n* Stroke with at least 6 months after ictus\n\nExclusion Criteria:\n\n* Metallic implants in spinal cord\n* Major orthopedic\u002Frheumatological disorders\n* Inability of verbal or non-verbal communication",{"count":84,"type":21},[140],"The aim of this clinical trial is to determine if cerebello-spinal direct current stimulation (csDCS) is effective in treating gait disorders in individuals with chronic stroke. Additionally, the trial seeks to evaluate the safety of this technique.\n\nThe primary objectives include:\n\nInvestigating whether cerebello-spinal direct current stimulation improves gait and functional mobility in participants with chronic stroke.\n\nAssessing any potential side effects associated with the method.\n\nResearchers will conduct a comparative analysis between cerebello-spinal direct current stimulation and a sham procedure (which mimics the stimulation without any actual effect) to assess its effectiveness in addressing gait disorders and enhancing mobility.\n\nParticipants in the trial will:\n\nUndergo cerebello-spinal direct current stimulation combined with treadmill training or a sham procedure with treadmill training daily over a two-week period.",[163,164,165],"Stroke Rehabilitation","Gait Disorders, Neurologic","tDCS",[167,91,168,169,170],"spinal cord","gait","rehabilitation","direct current stimulation","2025-07-09",{"date":173,"type":32},"2025-07-18",{"date":175,"type":32},"2024-05-01",{"date":177,"type":21},"2026-08-01",{"name":38,"class":39},3,{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":186,"targetDuration":4,"studyType":52,"phases":187,"briefSummary":188,"conditions":189,"keywords":191,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":201,"locationsCount":179},"100561670","efficacy-of-trans-spinal-magnetic-stimulation-on-functional-mobility-in-chronic-stroke-patients-100561670","NCT06593184","Efficacy of Trans-spinal Magnetic Stimulation on Functional Mobility in Chronic Stroke Patients","Inclusion Criteria:\n\n* Confirmation of Stroke by digital or physical imaging or medical report\n* Gait impairment\n* Stroke with at least 6 months after ictus\n\nExclusion Criteria:\n\n* Metallic implants in spinal cord\n* Major orthopedic\u002Frheumatological disorders\n* Incapacity of verbal or non-verbal communication",{"count":84,"type":21},[54],"The goal of this clinical trial is to learn if trans-spinal magnetic stimulation works to treat gait disorders in chronic stroke adults. It will also learn about the safety of trans-spinal magnetic stimulation.\n\nThe main questions it aims to answer are:\n\nDoes trans-spinal magnetic stimulation enhance chronic stroke participants gait and functional mobility? Does the technique cause any side effects?\n\nResearchers will compare trans-spinal magnetic stimulation to a sham (a look-alike stimulation with no real effect) to see if trans-spinal magnetic stimulation works to treat gait disorders and improve functional mobility.\n\nParticipants will:\n\nReceive trans-spinal magnetic stimulation with treadmill training or a sham stimulation with treadmill training every day for 2 weeks.",[190,164,88],"Stroke Sequelae",[192,193,194,88],"Spinal cord","Magnetic Stimulation","Trans-spinal magnetic stimulation","2025-06-18",{"date":197,"type":32},"2025-06-24",{"date":199,"type":32},"2024-06-01",{"date":97,"type":21},{"name":38,"class":39},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":208,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":209,"targetDuration":4,"studyType":52,"phases":211,"briefSummary":213,"conditions":214,"keywords":216,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":40},"100594923","phase-1-effects-of-peripheral-magnetic-stimulation-on-cortical-excitability-in-healthy-individuals-100594923","NCT07025759","Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals","Inclusion criteria: Healthy adults aged 18-40 years, both sexes, right-handed (confirmed via Edinburgh Handedness Inventory), and for females, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability.\n\nExclusion criteria: Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions interfering with assessments or interventions; or use of substances altering nervous system excitability.",true,{"count":210,"type":21},18,[212],"PHASE1","This study investigates the immediate effects of different parameters (frequency, intensity, and pulse number) of peripheral magnetic stimulation (rPMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEPs), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.",[215],"Healthy Individuals",[217,218],"Peripheral Magnetic Stimulation","Cortical Excitabilty","2025-06-16",{"date":221,"type":32},"2025-06-17",{"date":223,"type":32},"2022-10-01",{"date":225,"type":21},"2025-10",{"name":38,"class":39},{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":208,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":233,"targetDuration":4,"studyType":52,"phases":234,"briefSummary":235,"conditions":236,"keywords":237,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":241,"completionDateStruct":242,"leadSponsor":244,"locationsCount":40},"100595000","phase-1-effects-of-trans-spinal-magnetic-stimulation-on-cortical-excitability-in-healthy-individuals-100595000","NCT07026760","Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals","Healthy adults aged 18-40 years, of both sexes; right-handed (confirmed via the Edinburgh Handedness Inventory); and for women, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability.\n\nExclusion Criteria:\n\nPregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions that could interfere with assessments or interventions; or use of substances that alter nervous system excitability.",{"count":210,"type":21},[212],"This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEP), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.",[215],[194,238],"Cortical Excitability","2025-06-10",{"date":195,"type":32},{"date":223,"type":32},{"date":243,"type":21},"2025-10-30",{"name":38,"class":39},{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":251,"eligibilityCriteria":252,"healthyVolunteers":208,"sex":17,"minAge":253,"maxAge":254,"enrollmentInfo":255,"targetDuration":4,"studyType":52,"phases":257,"briefSummary":258,"conditions":259,"keywords":265,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":40},"100580019","effects-of-music-and-storytelling-on-linguistic-socioemotional-and-adaptive-development-in-children-aged-12-36-months-an-intervention-protocol-in-municipal-early-childhood-centers-100580019","NCT06831851","Effects of Music and Storytelling on Linguistic, Socioemotional, and Adaptive Development in Children Aged 12-36 Months: an Intervention Protocol in Municipal Early Childhood Centers","The Influence of Music and Storytelling on the Linguistic, Socioemotional, and Adaptive Development of Children Aged 12-36 Months: an Intervention Protocol in an Enriched Environment Conducted in Municipal Early Childhood Education Centers (CMEIs)","MUS-STORY","Inclusion Criteria:\n\nChildren of both sexes, aged between 12 and 36 months. Enrolled full-time in Municipal Early Childhood Education Centers (CMEIs). Attending with a daily workload of 10 hours, five days a week.\n\nExclusion Criteria:\n\nDiagnosis of atypical neurodevelopment. Use of sedative or stimulant medications for memory. Undergoing physical therapy for the locomotor system. Presence of any clinical or functional condition that prevents participation. More than five consecutive absences from the intervention program.","12 Months","36 Months",{"count":256,"type":21},16,[54],"This randomized clinical trial aims to evaluate the impact of a structured enriched environment on the linguistic, adaptive behavior, and socioemotional development of children aged 12 to 36 months. The study addresses two main questions:\n\nDoes the intervention improve linguistic, adaptive behavior, and socioemotional development compared to standard care? Does parental guidance amplify the benefits of the intervention?\n\nParticipants will be randomly assigned to one of two groups:\n\nIntervention Group:\n\nChildren will participate in musical activities twice per week (singing, exploring simple instruments, and musical games) and daily storytelling sessions using interactive and visual aids.\n\nWithin this group, parents in the \"with guidance\" subgroup will attend biweekly meetings to learn strategies for reinforcing the intervention at home, while the \"without guidance\" subgroup will not include parental training.\n\nControl Group:\n\nChildren will receive standard care complemented by alternative artistic and pedagogical activities (e.g., drawing, painting), without the structured intervention.",[260,261,262,263,264],"Child Development","Adaptive Behavior","Early Child Development","Music Education","Preschool Education",[266,267,268,269,270],"Environmental enrichment","Child development","Early childhood education","Adaptive behavior","Randomized clinical trial","2025-03-24",{"date":273,"type":32},"2025-03-26",{"date":275,"type":21},"2025-06-02",{"date":277,"type":21},"2025-11",{"name":38,"class":39},{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":287,"enrollmentInfo":288,"targetDuration":4,"studyType":52,"phases":290,"briefSummary":291,"conditions":292,"keywords":294,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":40},"100583041","efficacy-of-inspiratory-muscle-training-associated-with-manual-techniques-in-individuals-with-gerd-100583041","NCT06871163","EFFICACY OF INSPIRATORY MUSCLE TRAINING ASSOCIATED WITH MANUAL TECHNIQUES IN INDIVIDUALS WITH GERD","EFFICACY OF INSPIRATORY MUSCLE TRAINING ASSOCIATED WITH MANUAL TECHNIQUES FOR THE LOWER ESOPHAGEAL SPHINCTER AND DIAPHRAGMATIC RELEASE IN INDIVIDUALS WITH GASTROESOPHAGEAL REFLUX DISEASE: A RANDOMIZED CLINICAL TRIAL","GERD","Inclusion Criteria:\n\n* Individuals diagnosed with gastroesophageal reflux disease (GERD)\n* using 20 mg of proton pump inhibitors (PPIs).\n\nExclusion Criteria:\n\n* Individuals with a hiatal hernia \\>3 cm,\n* chronic lung diseases (chronic obstructive pulmonary disease and interstitial lung diseases)\n* severe heart diseases,\n* history of previous abdominal and\u002For thoracic surgeries, rib fractures within the past year,\n* severe osteoporosis\n* BMI \\>30 kg\u002Fm²","74 Years",{"count":289,"type":21},60,[54],"The objective of this clinical trial is to investigate the efficacy of inspiratory muscle training (IMT) combined with manual techniques for the lower esophageal sphincter (MTLES) and diaphragmatic release (DRT) in patients with Gastroesophageal Reflux Disease (GERD). The main questions it aims to answer are:\n\n1. If the combination of IMT, DRT, and MTLES can improve GERD symptoms and patients' quality of life.\n2. If the home-based IMT protocol, with weekly adjustments, and the manual techniques applied twice a week can have a positive impact on various clinical measures, such as pressure at the lower esophageal sphincter, reflux episodes, and quality of life.\n\nThe researchers will compare three groups: Group 1 (IMT), Group 2 (IMT + DRT + MTLES), and Group 3 (control, sham), to see if the group receiving IMT combined with DRT and MTLES shows greater improvements compared to the control group.\n\nParticipants will perform inspiratory muscle training at home, following a protocol adjusted weekly, and will receive manual techniques twice a week.",[293],"Gastroesophageal Reflux Disease (GERD)",[295,296,297],"inspiratory muscle training (IMT)","diaphragmatic release","manual techniques for the lower esophageal sphincter","2025-03-06",{"date":300,"type":32},"2025-03-11",{"date":302,"type":21},"2025-04",{"date":304,"type":21},"2027-02",{"name":38,"class":39},{"id":307,"slug":308,"hasResults":11,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":11,"sex":17,"minAge":108,"maxAge":4,"enrollmentInfo":313,"targetDuration":4,"studyType":52,"phases":315,"briefSummary":316,"conditions":317,"keywords":319,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":40},"100581948","csdcs-on-functional-mobility-in-parkinsons-disease-100581948","NCT06856941","CsDCS on Functional Mobility in Parkinsons Disease","Cerebello-spinal Direct Current Stimulation Associated with Treadmill Gait Training in Functional Mobility in Patients with Parkinsons Disease","Inclusion Criteria:\n\n* a clinical diagnosis of PD provided by a neurologist\n* regular dopaminergic drug treatment (at least three months of use)\n* aged 40 years or over\n* staging I to IV on the modified Hoehn and Yahr scale\n\nExclusion Criteria:\n\n* other neurological disorders, postural hypotension, vestibular, musculoskeletal or visual disorders that compromise performance in the proposed tests\n* other osteoarticular diseases in the lower limbs that interfere with performance and locomotion\n* a Montreal Cognitive Assessment (MoCA) score of less than 21 points\n* have undergone previous surgery for PD",{"count":314,"type":21},66,[54],"Parkinsons disease is a progressive neurological disorder marked by a decline in the efficacy of dopaminergic synapses in the nigrostriatal pathway, causing motor disturbances. Resting tremor, bradykinesia, and muscle rigidity are the most prominent motor features. These factors result in gait impairments, including slowness and freezing. The primary treatment for the disease is medication. However, while medication does reduce motor symptoms, prolonged usage may lead to an increase of dyskinesias and a worsening of a patients clinical condition. Thus, alternative therapies, such as cerebellospinal direct current stimulation (csDCS), have gained popularity. Studies suggest that csDCS may be an effective approach to mitigate gait disorders in this patient population. Kinesiotherapy is an established therapeutic method that has been demonstrated to promote functional mobility and improve gait. To date, the combination of kinesiotherapy and csDCS has not been tested, thus the purpose of this study is to evaluate the effectiveness of this combined therapy for enhancing functional mobility in Parkinsons disease patients. The goal of this study is to assess the efficacy of blending csDCS and kinesiotherapy for improving patients functional mobility in Parkinsons disease. Two groups of volunteers will be assigned: i) actual csDCS + kinesiotherapy, and ii) sham csDCS + kinesiotherapy. The full procedure involves 10 therapy sessions conducted across two weeks.",[318],"Parkinson Disease",[320,321,322,323],"gait training","parkinson disease","functional mobility","csDCS","2025-02-26",{"date":326,"type":32},"2025-03-04",{"date":328,"type":32},"2024-05-09",{"date":330,"type":21},"2026-03",{"name":38,"class":39},{"id":333,"slug":334,"hasResults":11,"nctId":335,"briefTitle":336,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":208,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":338,"targetDuration":4,"studyType":52,"phases":340,"briefSummary":341,"conditions":342,"keywords":360,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":371,"leadSponsor":373,"locationsCount":40},"100576631","proteomic-analysis-of-patients-undergoing-bariatric-surgery-100576631","NCT06787807","Proteomic Analysis of Patients Undergoing Bariatric Surgery","Inclusion Criteria:\n\n* patients over 18 years of age with a BMI above 35 kg\u002Fm² associated with comorbidity or BMI above 40 kg\u002Fm² without comorbidities,\n\nExclusion Criteria:\n\n* Patients with a previous history of cancer;\n* Underage patients\n* Patients with other diseases predisposing to the development of cancer: cirrhosis, ulcerative colitis, Barrett's esophagus, etc.\n* Patients who have previously undergone bariatric surgery;",{"count":339,"type":21},103,[54],"The expression of proteins in the blood of obese individuals is different from the expression of proteins in healthy individuals, and is also different in individuals after bariatric surgery. Therefore, this research aims to better understand protein expression in patients indicated for surgical treatment of obesity, evaluating the pre-operative and post-operative status. The objective of this research is to better understand protein expression in patients indicated for surgical treatment of obesity, evaluating the pre-operative and post-surgery status.",[343,344,345,346,347,348,349,350,351,352,353,354,355,356,357,358,359],"Obesity","Colon Cancer","Thyroid Cancer","Esophageal Cancer","Pancreatic Cancer","Gastric Cancer","Potmenopausal Breast Cancer","Endometrial Cancer","Liver Cancer","Gallbladder Cancer","Prostate Cancer","Ovarian","Kidney Cancer","Multiple Myeloma","Meningioma","Breast Cancer","Ovarian Cancer",[361,362,363,364,365,366],"obesity","cancer","bariatric surgery","proteomics","biomarkers","mass spectrometry","2025-01-16",{"date":369,"type":32},"2025-01-22",{"date":239,"type":21},{"date":372,"type":21},"2025-12",{"name":38,"class":39},{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":378,"acronym":4,"eligibilityCriteria":379,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":380,"targetDuration":4,"studyType":52,"phases":382,"briefSummary":383,"conditions":384,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":4},"100571754","transspinal-direct-current-stimulation-on-functional-mobility-in-post-stroke-patients-100571754","NCT06724367","TRANSSPINAL DIRECT CURRENT STIMULATION ON FUNCTIONAL MOBILITY IN POST-STROKE PATIENTS","Inclusion Criteria:\n\n* Clinical diagnosis of ischemic or hemorrhagic stroke, provided by a neurologist.\n* Age group greater than or equal to 18 years, of both sexes.\n* Any stage of the disease.\n* Presence of lower limb sensorimotor disorder related to the stroke\n* Absence of cognitive impairment verified through the Mini Mental State Examination (score ≥ 18 for illiterate individuals and ≥ 24 for educated individuals) modified for the Brazilian population.\n\nExclusion Criteria:\n\n* With other neurological injuries\n* With vestibular, visual, cardiovascular or osteomyoarticular disorders of the lower limb that may affect the performance of the proposed tests\n* Who have a pacemaker or metallic implants in their spine",{"count":381,"type":21},20,[54],"The aim of this clinical trial is to investigate the effects of transspinal direct current stimulation on the functional mobility of post-stroke patients.\n\nThe main question it aims to answer is:\n\nIs transspinal direct current stimulation able to improve functional mobility in post-stroke patients?\n\nThe researchers will compare transspinal direct current stimulation associated with gait training with sham transspinal direct current stimulation associated with gait training. To verify the effects of stimulation on the functional mobility of post-stroke patients.\n\nParticipants:\n\n* They will be assessed before starting the care, after the care has been completed, 15 and 30 days after the care has been completed.\n* They will take part in 10 sessions of transspinal direct current stimulation associated with gait training.",[88],"2024-12-06",{"date":387,"type":32},"2024-12-09",{"date":389,"type":21},"2024-12-20",{"date":391,"type":21},"2026-03-31",{"name":38,"class":39},{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":208,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":400,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":402,"conditions":403,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":40},"100560569","immunonutrition-and-psychosocial-factors-in-the-recovery-of-patients-after-gastrectomy-a-multidimensional-analysis-100560569","NCT06578858","Immunonutrition and Psychosocial Factors in the Recovery of Patients After Gastrectomy: a Multidimensional Analysis","Immunonutrition and Psychosocial Factors in the Recovery of Patients After Gastric Cancer Surgery: a Multidimensional Analysis","Inclusion Criteria:\n\nAdult or elderly patients (age ≥ 18 years) Treated at Consultório Guararapes Underwent surgery to remove gastric cancer Used immunonutrition in the pre, post, or perioperative period Applicable to both sexes\n\nExclusion Criteria:\n\nPre-existing hematologic diseases that may affect blood count results History of drug abuse (legal and\u002For illegal) Presence of other neoplasms History of psychological disorders affecting ability to respond to study questionnaires",{"count":401,"type":21},40,"To conduct this research, the following guiding question was formulated: \"Can immunonutrition, combined with the assessment of SOC and resilience, provide a broad view of the physical and psychological results during the treatment and recovery process of patients undergoing gastric cancer surgery?\". This led to the formulation of the following hypothesis: \"Patients who received immunonutrition and who have higher levels of resilience and sense of coherence will tend to exhibit more favorable clinical and laboratory outcomes for recovery after gastric cancer surgery.\n\nIn order to answer the question and test the study hypothesis, the general objective consisted of:\n\nTo evaluate the association of clinical and laboratory outcomes with the sense of coherence and resilience of patients undergoing gastric cancer surgery who received immunonutrition.\n\nIn view of this general objective, the following specific objectives were formulated:\n\n* To evaluate the levels of resilience and sense of coherence in patients undergoing gastric cancer surgery who received immunonutrition.\n* Analyze the results of blood count and C-Reactive Protein (CRP) in patients who received immunonutrition after gastric cancer surgery.\n* Identify the association between resilience levels, sense of coherence, blood count and CRP values with clinical outcomes, such as length of hospital stay and wound recovery, in patients undergoing gastric cancer surgery who used immunonutrition.",[348,404,405],"Salutogenesis","Sense of Coherence","2024-08-28",{"date":408,"type":32},"2024-08-29",{"date":410,"type":21},"2024-11",{"date":412,"type":21},"2024-12",{"name":38,"class":39},""]