[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidade Federal de Sao Carlos\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":208},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,44,77,103,132,158,187],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100634827","effects-of-biopsychosocial-models-based-on-pain-or-functionality-in-the-treatment-of-chronic-musculoskeletal-pain-100634827",false,"NCT07544745","Effects of Biopsychosocial Models Based on Pain or Functionality in the Treatment of Chronic Musculoskeletal Pain","Effects of a Biopsychosocial Model Centered on Functionality in the Care of Individuals With Chronic Musculoskeletal Pain in a Specialized Health Service: A Retrospective Cohort Study","Inclusion Criteria:\n\n* Aged 18 years or older\n* Chronic musculoskeletal pain\n* Have previously undergone unsuccessful pain treatment\n* Referred from the municipal healthcare system to the Pain Clinic\n* Undergo treatment at the Pain Clinic for a period of 3 months.\n\nExclusion Criteria:\n\n* Uncontrolled diabetes mellitus\n* Recent postoperative status\n* Neurological conditions with significant motor impairments\n* Individuals with oncological conditions\n* Dementia\n* Psychopathy\n* Schizophrenia\n* Other severe mental disorders\n* Individuals presenting only acute pain conditions.","ALL","18 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","The objective of this study is to evaluate whether a functionality-centered biopsychosocial model can improve clinical outcomes in the care of individuals with chronic musculoskeletal pain treated in a specialized healthcare service. The main questions it aims to answer are:\n\nDoes the functionality-centered biopsychosocial model lead to a greater reduction in pain intensity compared to the pain-centered biopsychosocial model?\n\nDoes the functionality-centered biopsychosocial model lead to greater improvement in functionality and performance of daily activities in individuals with chronic pain?\n\nResearchers will compare individuals treated using a functionality-centered biopsychosocial model with individuals treated using a pain-centered biopsychosocial model to determine whether the functionality-centered model results in better clinical outcomes and greater treatment adherence.\n\nParticipants will:\n\nAttend weekly interdisciplinary appointments in a specialized chronic pain service for approximately 3 months.\n\nUndergo clinical assessments recorded in their medical records, including measures of pain intensity, pain interference, and functional status.\n\nParticipate in interdisciplinary therapeutic interventions based on the biopsychosocial model, which may include pain neuroscience education, therapeutic exercises, behavioral strategies, and the establishment of functional goals.",[26],"Chronic Pain",[28,29,30,31],"chronic pain","interdisciplinary healthcare team","cost-effectiveness","biopsychosocial model","NOT_YET_RECRUITING","2026-04-23",{"date":35,"type":36},"2026-04-29","ACTUAL",{"date":38,"type":20},"2026-04",{"date":40,"type":20},"2026-12",{"name":42,"class":43},"Universidade Federal de Sao Carlos","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":75,"locationsCount":76},"100610212","whole-body-photobiomodulation-use-in-professional-soccer-players-during-a-state-championship-100610212","NCT07224646","Whole-Body Photobiomodulation Use in Professional Soccer Players During a State Championship","WBPBM-PSC","Inclusion Criteria:\n\n* Male professional soccer players currently competing in the championship\n* Age 18-35 years\n* Training frequency ≥5 times per week\n* Able to attend all PBM\u002Fsham sessions and all assessments during the 8-week intervention\n* Signed informed consent\n\nExclusion Criteria:\n\n* Lower-limb musculoskeletal injury in the last 6 months or currently receiving treatment\n* Current use of phototherapy or any other recovery-enhancing modality\n* Chronic medical conditions that may affect performance or recovery\n* Known sensitivity or contraindication to light-based therapies\n* Inability to comply with the intervention or training schedule",true,"MALE","35 Years",{"count":19,"type":20},[23],"This study aims to investigate the effects of whole-body photobiomodulation on professional soccer players during a state championship. The primary question is whether photobiomodulation improves recovery, reduces muscle fatigue, and enhances performance compared to standard training without photobiomodulation.",[58,59,60,61],"Athletic Performance","Muscle Fatigue","Muscle Strength","Sports",[63,64,65,66,67],"Phototherapy","Laser therapy","Muscle fatigue","Muscle damage","Soccer","RECRUITING","2025-11-21",{"date":71,"type":36},"2025-11-24",{"date":73,"type":36},"2025-09-04",{"date":40,"type":20},{"name":42,"class":43},1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":76},"100581784","cognitive-functional-therapy-versus-exercises-for-chronic-shoulder-pain-100581784","NCT06854809","Cognitive Functional Therapy Versus Exercises for Chronic Shoulder Pain","Effects of Cognitive Functional Therapy Versus Therapeutic Exercises in Individuals With Chronic Shoulder Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\nIndividuals of both sexes, aged between 18 and 65 years, will be included if they have had shoulder pain for at least 3 months and report a pain intensity of at least 3 points on the Numeric Pain Rating Scale (NPRS) at rest or during arm movement. Additionally, they must have a minimum score of 20 points on the Shoulder Pain and Disability Index (SPADI).\n\nExclusion Criteria:\n\nIndividuals will not be included if they have adhesive capsulitis, defined as a loss of more than 50% of passive shoulder range of motion in external rotation; previous shoulder surgery; a history of shoulder fracture; systemic musculoskeletal diseases (e.g., rheumatoid arthritis, fibromyalgia); shoulder pain reproduced by active or passive cervical spine movement; signs of glenohumeral instability identified by a positive sulcus test or a positive apprehension test indicating laxity in the glenohumeral joint; self-reported systemic disease; a positive drop arm test; pregnancy; active cancer treatment; neurological diseases; cognitive impairments; corticosteroid injection within three months prior to the intervention; or physical therapy in the three months preceding the study.\n\nParticipants will be discontinued from the study if they experience fractures, surgeries, musculoskeletal or neural injuries that prevent access to treatment, or receive corticosteroid injections during the treatment or follow-up period.","65 Years",{"count":86,"type":20},148,[23],"The objective of this clinical trial is to determine whether cognitive functional therapy is superior to therapeutic exercises for the treatment of chronic shoulder pain. The main questions it aims to answer are:\n\nIs cognitive functional therapy superior to therapeutic exercises for pain and disability in individuals with chronic shoulder pain? Is cognitive functional therapy superior to therapeutic exercises for functionality and psychosocial factors?\n\nParticipants will:\n\nReceive 4 to 8 sessions of cognitive functional therapy once a week for four to eight weeks.\n\nFollow a therapeutic exercise protocol for eight weeks with a frequency of twice per week.",[90],"Chronic Shoulder Pain",[92,93,94],"shoulder pain","Psychosocial Rehabilitation","exercise therapy","2025-06-13",{"date":97,"type":36},"2025-06-18",{"date":99,"type":20},"2025-07",{"date":101,"type":20},"2029-03",{"name":42,"class":43},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":21,"phases":113,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":76},"100582685","light-reflection-on-human-skin-in-whole-body-photobiomodulation-therapy-100582685","NCT06866522","Light Reflection on Human Skin in Whole-Body Photobiomodulation Therapy","Light Reflection on Human Skin in Whole-Body Photobiomodulation Therapy: Clinical Trial","Inclusion Criteria:\n\n* male and female\n* age between 18 and 30 years\n* body mass index (BMI) between 18.5 and 29.9 kg\u002Fm2.\n\nExclusion Criteria:\n\n* tattoo in the light reflection assessment areas\n* history of skin cancer\n* skin lesions such as open wounds in the mid-thigh, abdomen, biceps brachii, back and calf\n* patients with cognitive difficulty reporting thermal sensation","30 Years",{"count":112,"type":20},72,[23],"Photobiomodulation therapy (PBMT) is based on exposing biological tissues to low-intensity light, with effects depending on the light-tissue interaction. When irradiated without skin contact, part of the incident light is reflected and lost. In this context, the amount of reflected light in PBMT applied without skin contact, as well as the influence of skin phototype, has not yet been established. Objective: To quantify the reflection of light from PBMT on the skin of men and women aged 18 to 30 years, considering skin phototypes. Methodology: Participants will be divided into three groups based on skin phototype (Group 1: phototypes I and II; Group 2: phototypes III and IV; Group 3: phototypes V and VI) and sex. They will be subjected to whole-body PBMT with red light (660 nm; 31.85±3.85 mW; 45.50±5.07 mW\u002Fcm²) and infrared light (850 nm; 25.29±2.99 mW; 36.13±4.27 mW\u002Fcm²) at 20 cm from the light-emitting source, with measurement of light reflection in the regions of the brachial biceps, abdomen, lumbar, anterior and posterior thigh, and calf using a power and energy analyzer (powermeter PM100D and sensor S130C, 0.7 cm²). Data will be analyzed for normality and groups were compared with a significance level of 5%",[116,117],"Photobiomodulation Therapy","Phototype",[119,120,121,122,123],"photobiomodulation","low-level laser therapy","skin optics","melanin","light reflection","2025-03-07",{"date":126,"type":36},"2025-03-12",{"date":128,"type":36},"2023-11-27",{"date":130,"type":20},"2025-07-20",{"name":42,"class":43},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":21,"phases":143,"briefSummary":144,"conditions":145,"keywords":147,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":76},"100568244","acute-effect-of-photobiomodulation-in-individuals-with-hypertension-100568244","NCT06678698","Acute Effect of Photobiomodulation in Individuals with Hypertension","Acute Effect of Photobiomodulation on Blood Pressure, Endothelial Function and Arterial Stiffness in Individuals with Hypertension: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Sedentary or irregularly inactive individuals (IPAQ)\n* Both sexes\n* Age between 40 to 60 years old\n* Clinical diagnosis of hypertension for at least 3 months with difficulty in blood pressure control\n* Hypertension classification up to stage 2\n* Individuals who have a prescription for hypertension control drugs and have been using these drugs for at least 3 months\n\nExclusion Criteria:\n\n* Diabetes diagnosis\n* Smokers\n* BMI \\> 30 kg\u002Fm²\n* Cardiac pacemaker use\n* Presence of arrhythmias or other decompensated cardiovascular diseases\n* Musculoskeletal, orthopedic or neurological conditions that make it unable to participate in the procedures\n* Presence of cognitive deficits that make it difficult to understand the assessments\n* Presence of active neoplasia, under suspicion or after 5 years in remission period\n* Presence of tattoos (covering a large body area, or the anterior wrist region)\n* Photosensitive drugs use\n* Pregnant women or under suspicion\n* Presence of epilepsy or seizures\n* Participants who present a systolic blood pressure ≥ 180 mmHg and\u002For diastolic blood pressure ≥ 110 mmHg on the day of the intervention","40 Years","60 Years",{"count":142,"type":20},48,[23],"This is a randomized, double-blind and sham-controlled clinical trial that aims to evaluate and compare the acute effect of full-body photobiomodulation (PBM) and modified ILIB (Intravascular laser irradiation of blood) on blood pressure, endothelial function and arterial stiffness in individuals with hypertension. Participants (n=48) will be equally, randomly and secretly allocated into one of 4 groups: Panel Group; Panel Sham Group; Modified ILIB group; and Modified ILIB Sham Group. Participants aged 40 to 60 years old, diagnosed with hypertension and using control drugs for at least 3 months will be included. Participants will be assessed at pre- and post-intervention for: BP; endothelial function; arterial stiffness; blood nitrite; and thermography. In the post-intervention period, the ambulatory blood pressure monitoring will also be carried out. Participants will receive a single application of PBM, which, depending on the group, may be full-body irradiation from an LED panel (660 nm; 25.34 J\u002Fcm²; 42.24 mW\u002Fcm²), modified ILIB (660 nm; 42,462 J\u002Fcm²; 35.385 W\u002Fcm²), or the respective sham therapies. Data homogeneity and normality will be verified by the Levene and Shapiro-Wilk tests, which will determine the choice of subsequent tests. A statistical significance of 5% will be considered.",[146],"Hypertension",[148,119,149],"hypertension","low-level light therapy","2024-11-06",{"date":152,"type":36},"2024-11-08",{"date":154,"type":36},"2024-05-01",{"date":156,"type":20},"2025-01-30",{"name":42,"class":43},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":51,"sex":16,"minAge":166,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":21,"phases":170,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":76},"100560037","effect-of-task-specific-training-in-an-augmented-reality-context-on-upper-limb-function-and-activities-in-children-with-spastic-cerebral-palsy-100560037","NCT06571929","Effect of Task-Specific Training in an Augmented Reality Context on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy","Effect of Task-Specific Training in Augmented Reality Context (INTERACT Protocol) on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy: A Randomized Controlled Trial","INTERACT","Inclusion Criteria:\n\n* In the experimental and control groups, children who have been medically diagnosed with cerebral palsy, either unilateral or bilateral, with spasticity classification, will be included.\n* Participants must be classified at GMFCS levels I and II, meaning they are capable of walking independently.\n* The MACS (Manual Ability Classification System) should be between levels I (manipulates objects easily), II (manipulates most objects with reduced quality and speed), and III (manipulates objects with difficulty).\n* The modified Ashworth score should be between 0 and 2.\n* Ability to understand verbal commands and good comprehension of the proposed games.\n\nExclusion Criteria:\n\n* Children with dystonic tone classification (identified by the Hypertonia Assessment Tool (HAT)), athetoid, or ataxic.\n* GMFCS levels III, IV, and V.\n* MACS levels IV and V.\n* Modified Ashworth score of 3 to 4.\n* Undergoing orthopedic surgical procedures within the past year.\n* Receiving chemical blocks within the last 6 months.\n* Deformities (muscle shortening and\u002For loss of joint mobility in the upper limbs) that prevent or compromise the ability to reach the midline.\n* Presence of visual and\u002For auditory sensory deficits not corrected with devices.\n* Use of medications that may alter muscle strength or tone.\n* Cardiovascular limitations of any intensity, such as excessive fatigue, low exercise tolerance.\n* Children who have undergone other intensive therapies within the past 6 months.\n* Children with cognitive impairment indicated by caregivers or perceived by researchers due to difficulties in understanding verbal commands and virtual reality games.\n* Children who do not accept playing augmented reality games.","6 Years","12 Years",{"count":169,"type":20},34,[23],"Children with Cerebral Palsy (CP), a condition that affects movement and coordination, face difficulties in daily activities such as dressing, reaching for objects in high places, and getting up from seats. These challenges can negatively impact the quality of life for these children. Therefore, it is essential to seek effective treatments that help improve these skills.\n\nThe use of technology in treatments, especially with games that utilize augmented reality (AR), has proven to be a good strategy. This technique aids motor learning, improving the skills that children struggle with while also increasing motivation, allowing them to engage in activities they enjoy. However, the application of AR in children with CP is still limited.\n\nIn this context, it is crucial to provide appropriate treatments for these children, harnessing the benefits of AR technology. This study aims to investigate the effects of a protocol called \"INTERACT protocol,\" which consists of training activities that interest children, such as reaching for objects and getting up from a bench. These activities are linked to AR games and will be conducted with accessible equipment for children with CP, aiming to improve their quality of life.\n\nThe children selected for the research will be divided into two groups: the experimental group (INTERACT) and the control group. This division will be done by random draw. The children in the control group will continue receiving the physiotherapy they are already undergoing for the same duration as the children in the INTERACT group. All children will participate in the treatment for 4 weeks, three times a week, with sessions lasting 1 hour and 20 minutes each.\n\nOur hypothesis is that the children participating in the INTERACT protocol will show improvements in activities involving reaching for objects and in the transition from sitting to standing.",[173],"Cerebral Palsy, Spastic",[175,176,177,178],"Cerebral Palsy","Children","Games","Augmented reality","2024-08-22",{"date":181,"type":36},"2024-08-26",{"date":183,"type":36},"2024-05-21",{"date":185,"type":20},"2026-11",{"name":42,"class":43},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":16,"minAge":194,"maxAge":140,"enrollmentInfo":195,"targetDuration":4,"studyType":21,"phases":196,"briefSummary":197,"conditions":198,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":76},"100536016","pain-science-education-administered-in-full-or-fractioned-dosage-modes-for-temporomandibular-disorders-100536016","NCT06259344","Pain Science Education Administered in Full or Fractioned Dosage Modes for Temporomandibular Disorders","Effect of Pain Science Education Administered in Full or Fractioned Dosage Modes Associated With Conventional Treatment on Pain Intensity and Disability for Temporomandibular Disorders: a Randomized Controlled Trial","Inclusion Criteria:\n\n* age between 20 and 60 years;\n* painful TMD (confirmed by applying DC\u002FTMD);\n* complaint of pain with a minimum intensity of 3 (on a scale of 0 to 10) present for at least 3 months;\n* fluency to speak and understand Brazilian Portuguese (Mini Cog instrument to assess cognitive capacity and the Cloze Test to certify textual reading comprehension)\n\nExclusion Criteria:\n\n* history of tumors in the orofacial region;\n* central and peripheral neurological diseases;\n* uncontrolled psychiatric illnesses;\n* pregnant women;\n* presence of toothache, neuralgia or chronic painful conditions in the head region, orofacial region or systemic pain (for example, fibromyalgia, osteoarthritis, osteoarthritis or rheumatological diseases);\n* report of previous major surgeries in the craniofacial region, such as orthognathic surgeries, TMJ surgeries, or resulting from post-trauma corrections;\n* history of major trauma involving the cervical or craniofacial region (facial trauma, whiplash injuries, etc.);\n* individuals undergoing physiotherapeutic treatment up to 6 months before the start of this study.","20 Years",{"count":86,"type":20},[23],"Temporomandibular Disorders (TMD) are a collection of musculoskeletal disorders which affect the masticatory structures and have a multifactorial etiology. A biopsychosocial approach is recommended for the management of these disorders including different interventions like exercise, manual therapy and pain education. The aim of this study is to compare the effect of a full dosage mode pain science education program (2 initial sessions of 45 minutes) versus a fractioned dosage format (6 sessions of 15 minutes) combined with manual therapy and orofacial exercises on primary outcomes - pain intensity and disability - and secondary outcomes - mandibular range of motion, pain-related self-efficacy, kinesiophobia, global perception of improvement, empathy, knowledge about pain neuroscience, beliefs about pain, exercise adherence, and catastrophizing - in patients with chronic painful TMD. This study will be a randomized controlled trial with a sample of 148 participants. Individuals will undergo a screening process to identify those with TMD diagnosis according to the Diagnostic Criteria for Temporomandibular Disorders (DC\u002FTMD), aged 20 to 60 years, of both genders, and then the volunteers will be randomized into two groups (G1: Full dosage mode pain science education program + Manual therapy\u002Forofacial and neck motor exercises vs. G2: Fractioned dosage mode pain science education program + Manual therapy\u002Forofacial and neck motor exercises). These volunteers will be recruited in the city of São Carlos, SP. The intervention will take place twice a week for 8 weeks, administered by a single therapist, each session lasting 1 hour. The primary outcomes will be pain intensity and disability, assessed using the numerical pain rating scale and the Craniofacial Pain and Disability Inventory (CFP-DI), respectively, and the secondary outcomes will be mandibular range of motion, pain-related self-efficacy, kinesiophobia, global perception of improvement, empathy, knowledge about pain neuroscience, beliefs about pain, exercise adherence, and catastrophizing, assessed using the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD), Global Perceived Effect of Improvement scale, Pain Self-Efficacy Questionnaire (PSEQ), CARE Empathy Scale, and Pain Catastrophizing Scale (PCS). For statistical analysis, a Generalized Estimated Equations considering time and groups as factors will be used. A significance level of p\\\u003C0.05 will be considered.",[199],"Temporomandibular Joint Disorders","2024-06-07",{"date":202,"type":36},"2024-06-11",{"date":204,"type":20},"2024-09-01",{"date":206,"type":20},"2027-12-10",{"name":42,"class":43},""]