[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidade Federal do Rio de Janeiro\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":239},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,73,104,143,175,216],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100639593","application-of-the-concept-of-proprioceptive-neuromuscular-facilitation-in-trunk-control-in-patients-admitted-to-the-icu-100639593",false,"NCT07584564","Application of the Concept of Proprioceptive Neuromuscular Facilitation in Trunk Control in Patients Admitted to the ICU.","Effects of Applying the Concept of Proprioceptive Neuromuscular Facilitation in Trunk Control in Patients Admitted to the ICU: A Randomized Clinical Trial.","PNF","Inclusion Criteria:\n\n* Over 18 years of age\n* ICU stay greater than or equal 48 hours;\n* RASS scale score greater than or equal to -2 and less than or equal to 1;\n* TCT score less than or equal to 12 points on the \"balance in sitting position\" score less than or equal to 2 on item 3 \"sitting without support\".\n\nExclusion Criteria:\n\n* Patients in a coma, with spinal cord instability, metastases, and bone lesions;\n* Neuromuscular or neurological diseases\n* Discharge from the general ICU before SBL\n* Proportional care phase 3;\n* Readmissions to the general ICU;","ALL","18 Years",{"count":20,"type":21},58,"ESTIMATED","INTERVENTIONAL",[24],"NA","Muscle weakness acquired in the ICU (FAUTI) is related to the functional decline of patients admitted to an Intensive Care Unit (ICU). For better follow-up, scales such as (Chelsea Critical Care Physical Assessment) CPAx and (Medical Research Council) MRC help to identify early the muscle and functional impairment of these patients. Early mobilization aims to minimize these effects and therefore the search to reach the highest mobility milestone is constant bedside sitting (BSS) is an important milestone in recovery, associated with better functional results when there is good trunk control, as the coordinated activation of muscles in this region is essential for stabilization and reaching higher postures. The physiotherapeutic approach focused on the components of the activities and on the patient's participation is crucial, with the therapeutic option of Proprioceptive Neuromuscular Facilitation (PNF). To evaluate the effect of exercises based on the PNF concept through the Test Control Trunk (TCT) on the trunk balance of patients admitted to the ICU. This is a randomized, crossover clinical trial, carried out at the Pedro Ernesto University Hospital from June 2026 to June 2027. Adults hospitalized for more than 48 hours who meet the inclusion criteria will be screened. and clinical evaluation. The study consists of two blocks of pre- and post-crossover evaluations, conducted by the same blind evaluator. Patients will undergo assessments on the first day of BSS, including assessment of the trunk with TCT and assessment of diaphragm mobility and thickness by ultrasound, before and after intervention (PNF or conventional exercises). Between assessments, there will be a 3-hour rest period.",[27],"Intensive Care Unit Acquired Weakness",[29,30,31],"Postural Balance","Proprioceptive Neuromuscular Facilitation","Diaphragm","NOT_YET_RECRUITING","2026-05-18",{"date":35,"type":36},"2026-05-22","ACTUAL",{"date":38,"type":21},"2026-06-01",{"date":40,"type":21},"2028-12-31",{"name":42,"class":43},"Universidade Federal do Rio de Janeiro","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":44},"100611433","to-compare-inflammatory-biomarkers-before-and-after-treatment-with-clobetasol-or-fractional-co2-laser-in-women-with-histologically-confirmed-vulvar-lichen-sclerosus-without-prior-corticosteroid-treatment-100611433","NCT07240519","To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment.","Vulvar Lichen Sclerosus: Expression of Inflammatory Markers in a Randomized Clinical Trial With Clobetasol Versus Laser","LASER","Inclusion Criteria: Women older than 21 years; histological diagnostic of vulvar lichen sclerosus and no previous treatment with topic corticoesteroid\n\nExclusion Criteria: Women that don't agree in taking part of the study; other concomitant vulvar diseases; pre malignant vulvar disease HPV dependent and independent; previous pelvic radiotherapy\n\n\\-","FEMALE","21 Years",{"count":56,"type":21},40,[24],"The present study is a Clinical trial that compares clobetasol ointment versus Fractional CO2 laser for vulvar lichen sclerosus (VLE) treatment confirmed by histology, with no previous treatment. Lichen sclerosus is a chronic inflamatory disease that affects the vulvar skin in the majority of cases, generally in peri and post menopause. The main symptom is pruritus, along with dispareunia and vulvar pain. If not treated, it can leads to vulvar anatomy distortion and altough small, there is risk of neoplastic transformation towards pre cancer and invasive vulvar cancer. Clobetasol ointment is the standard treatment, but prolonged use can cause some adverse effects, such as thinning the skin, fungal infections, and exacerbation of symptoms. Forty participants are being randomized to clobetasol group, three months with reducing frequency and the other group of participants, to fractional dioxid carbon (CO2) laser for three sessions four weeks apart. At the beggining and three months after the completion of each treatment, a punch biopsy will be taken for every participant. The principal aim is to compare some inflamatory biomarkers before and after each treatment and compare them by imunohistoquemestry at Imunology and Imunogenetic Laboratory in Fiocruz, Rio de janeiro, Brazil.\n\nSecondary outcomes include clinical response and changes in vulvar anatomy, assessed using the Sheinis \\& Selk questionnaire before and after each treatment, as well as the evaluation of some clinical aspects, such as improvement in itching, dyspareunia and appearance of the vulva, along with satisfaction with the treatment, using the Visual Analogue Scale (VAS) from 1 to 10.\n\nWith this study, the investigators want to know if fractional CO2 laser can reduce the inflammatory process and symptoms in vulvar lichen sclerosus such as itching, and if this could be an alternative treatment for this condition.",[60],"Vulvar Lichen Sclerosus",[62,63],"CO2 laser","vulvar lichen sclerosus","RECRUITING","2025-11-20",{"date":67,"type":36},"2025-11-26",{"date":69,"type":36},"2022-06-22",{"date":71,"type":21},"2026-06",{"name":42,"class":43},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":82,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":44},"100607683","functional-assessment-in-critically-ill-patients-100607683","NCT07191743","Functional Assessment in Critically Ill Patients","Assessment of Physical Function in Critically Ill Patients With the Chelsea Critical Care Assessment Tool (CPAX)","Inclusion Criteria: All adult patients admitted to the Pedro Ernesto University Hospital (HUPE) General ICU over 18 years of age and with an ICU stay greater than or equal to 48 hours will be included.\n\nExclusion Criteria:\n\n* Pregnancy\n* Inability to record the CPAx score within the first 48 hours of ICU admission or on the day of ICU discharge\n* ICU readmission\n* Known comorbidities causing generalized weakness, such as neuromuscular or neurological diseases",{"count":81,"type":21},186,"10 Days","OBSERVATIONAL","This longitudinal, prospective observational study aims to evaluate functional status in critically ill adult patients in the Intensive Care Unit using the Chelsea Critical Care Physical Assessment Tool (CPAx). The primary objective is to analyze CPAx score variation as a potential predictor of clinical outcomes, including mortality and duration of mechanical ventilation. Functional assessments will be performed at intensive care unit (ICU) admission and discharge to monitor changes in physical function and to predict adverse clinical outcomes.",[27,86],"Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)",[88,89,90,91,92,93,94,95],"Critical Care","Intensive Care Units","Physical Therapy Department, Hospital","Muscle Weakness","Functional Status","Physical Functional Performance","Outcome Assessment, Health Care","Rehabilitation","2025-09-21",{"date":98,"type":36},"2025-09-25",{"date":100,"type":36},"2025-01-01",{"date":102,"type":21},"2027-12-01",{"name":42,"class":43},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":117,"conditions":118,"keywords":124,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":44},"100597746","phase-2-clonidine-in-ultrasound-guided-rectus-sheath-block-for-outpatient-umbilical-hernioplasty-100597746","NCT07062497","Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty","Ultrasound-guided Rectus Abdominis Muscle Sheath Block in Outpatient Umbilical Hernioplasties: a Comparative Analysis of the Use of Clonidine as an Adjuvant - Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 65 years;\n* Both male and female participants;\n* ASA physical status I or II (American Society of Anesthesiologists classification);\n* Scheduled for elective ambulatory umbilical hernia repair;\n* Hernial defect size ≤ 4 cm (small to medium).\n\nExclusion Criteria:\n\n* Refusal or inability to provide written informed consent;\n* Cognitive or psychiatric disorders that impair comprehension or adherence to the study protocol;\n* Known allergy or hypersensitivity to local anesthetics, clonidine, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), or other analgesics;\n* Participation in another clinical trial within the previous 30 days;\n* Missing data or loss to follow-up during postoperative assessments;\n* Contraindications to regional anesthesia or known coagulopathy.","65 Years",{"count":113,"type":21},62,[115,116],"PHASE2","PHASE3","This clinical trial aims to evaluate the effectiveness of an ultrasound-guided nerve block technique as the sole anesthetic method for patients undergoing outpatient umbilical hernia surgery. The procedure, called rectus sheath block (RSB), involves injecting local anesthetic near the abdominal muscles to reduce pain during and after surgery. The study will compare two groups of adult patients: one receiving the nerve block with a medication called clonidine added to the anesthetic solution, and the other receiving the same block without clonidine. Clonidine may help improve pain control and reduce the need for additional pain medications. By analyzing pain scores, recovery quality, and potential side effects, the study seeks to determine whether the use of clonidine in this context is safe, cost-effective, and beneficial for patient recovery. Participants will answer questionnaires about their pain and recovery during the first 48 hours after surgery.",[119,120,121,122,123],"Hernia, Umbilical","Clonidine","Pain, Postoperative","Ambulatory Surgical Procedures","Regional Anesthesia Block",[125,126,127,120,128,129,130,131,132,133,134],"Rectus Sheath Block","Ultrasound-Guided Regional Anesthesia","Umbilical Hernia Repair","Local Anesthetics","Postoperative Pain Management","Ambulatory Surgery","Quality of Recovery","Alpha-2 Adrenergic Agonists","Pain Measurement","Analgesic Adjuvants","2025-07-10",{"date":137,"type":36},"2025-07-14",{"date":139,"type":36},"2025-01-07",{"date":141,"type":21},"2026-04-30",{"name":42,"class":43},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":150,"sex":17,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":155,"briefSummary":156,"conditions":157,"keywords":162,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":44},"100586213","sport-mouthguards-devices-for-preventing-dental-injuries-in-sports-100586213","NCT06912451","Sport Mouthguards: Devices for Preventing Dental Injuries in Sports","Sport Mouthguards: Devices for Preventing Dental and Alveolar Injuries in Sports - A Longitudinal Study","Inclusion Criteria:\n\n* Children, adolescents, and adults aged 7 to 30 years, with no systemic health issues, of both genders;\n* Engaging in sports practice at least twice a week.\n\nExclusion Criteria:\n\n* Presence of cavitated dental caries and\u002For periodontitis;\n* Angle Class III malocclusion with negative anterior overjet;\n* Presence of non-removable prostheses or any other accessory in the upper or lower arch that may interfere with the adaptation of the mouthguard;\n* Use of medications that may interfere with any salivary parameters;\n* Children, adolescents, and adults with neurological disorders or communication difficulties.",true,"7 Years","30 Years",{"count":154,"type":21},136,[24],"Objective: To evaluate the impact of mouthguards (MG) on acceptability, incidence of soft tissue injuries, periodontal and salivary parameters, as well as on the perception of the body in sports practice (PeCoPes) and on the quality of life of athletes, and evaluate the consequences of use on the characteristics, state of conservation, and biological and physical properties of the MG itself. Methodology: This is a longitudinal study that will include children, adolescents, and adults aged 7 to 30 years who practice sports and require MGs. Sociodemographic data, medical history, dental history, dietary habits, and sports practice data will be collected. Participants will undergo a complete oral clinical examination. Data on knowledge of traumatic dental injuries (TDI) and MGs will also be collected. Before the MG is delivered, immediately after installation, and at 1, 3, and 6 months after use, the following parameters will be evaluated: presence of mucosal injuries, visible plaque index, gingival bleeding index, salivary flow, salivary pH, buffering capacity, and salivary microorganism count. Acceptability will be evaluated before the MG is delivered, immediately after delivery, and at 1, 3, and 6 months after use. PeCoPes and quality of life will be assessed before, 1, 3, and 6 months after MG use. The MG will be evaluated for bacterial contamination, delamination, roughness, dimensional changes related to shape and thickness, color change, and conservation status. The data will be tabulated and analyzed using SPSS 21.0, and appropriate statistical tests (p\\\u003C0.05) will be performed according to the study objectives.",[158,159,160,161],"Oral Health","Dental Trauma","Oral Health Knowledge, Attitude and Practice Among Patients","Mouth Protectors",[161,163,164,159,165,166],"Athletes","Sports","Questionnaire","Oral health","2025-03-31",{"date":169,"type":36},"2025-04-04",{"date":171,"type":36},"2024-06-01",{"date":173,"type":21},"2025-12-26",{"name":42,"class":43},{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":150,"sex":17,"minAge":181,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":22,"phases":183,"briefSummary":184,"conditions":185,"keywords":197,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":44},"100572472","association-of-transcranial-alternating-current-stimulation-with-digital-cognitive-training-for-cognitive-remediation-in-older-adults-100572472","NCT06733714","Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults","Inclusion Criteria:\n\n* Healthy subjects over 50 years old, with cognitive complaints\n\nExclusion Criteria:\n\n* Estimated Intelligence Quotient \\\u003C80\n* Dependence on psychoactive substances (DSM-V)\n* Severe psychiatric or neurological disorders\n* Uncorrected visual\u002Fhearing problems\n* History of syncope for an unexplained reason or seizure less than a year ago\n* Previous stroke\n* Use of anticoagulants\n* Intracranial metallic prosthesis or cardiac pacemaker\n* Any contraindication to performing tACS","50 Years",{"count":56,"type":21},[24],"BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.\n\nDigital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints.\n\nMETHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.",[186,187,188,189,190,191,192,193,194,195,196],"Cognitive Dysfunction","Alzheimer Disease","Mild Cognitive Impairment","Cognitive Decline","Frontotemporal Degeneration","Dementia","Dementia, Vascular","Lewy Body Disease","Beta-Amyloid","GFAP","Tau Protein",[198,199,200,201,202,203,204,205,206,207],"tacs","nibs","transcranial alternate current stimulation","mild cognitive impairment","MCI","ALzheimer","Cognition","Elderly","Older Adults","Cognitive enhancement","2024-12-09",{"date":210,"type":36},"2024-12-13",{"date":212,"type":36},"2024-12-02",{"date":214,"type":21},"2027-03-01",{"name":42,"class":43},{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":223,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":224,"conditions":225,"keywords":228,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":44},"100551756","extremes-of-respiratory-effort-in-weaning-failure-from-mechanical-ventilation-a-prospective-observational-study-100551756","NCT06464224","Extremes of Respiratory Effort in Weaning Failure From Mechanical Ventilation: a Prospective Observational Study","Are the Extremes of Respiratory Efforts During Assisted Ventilation Associated With Weaning Failure in Critical Ill Patients: a Prospective Observational Study","Inclusion Criteria:\n\n* Patients over 18 years old, admitted to the Glória D'or hospital, undergoing orotracheal intubation and invasive mechanical ventilation, in their first 7 years on spontaneous ventilation, who accept to participate in the study by signing the free and informed consent form (or by their legal responsible).\n\nExclusion Criteria:\n\n* • Neuromuscular disease;\n\n  * Phrenic nerve injury;\n  * MV for less than 24 hours;\n  * Previously tracheostomized patient;\n  * Age under 18;\n  * Use of neuromuscular blocker \\> 72h;\n  * COPD;\n  * Patients with pulmonary fibrosis;\n  * Pregnancy;\n  * Patient under palliative care;\n  * COVID-19 pneumonia;\n  * Patients reintubated after extubation in this hospitalization for less than 3 weeks.",{"count":44,"type":21},"The presence of high levels of respiratory effort in patients under mechanical ventilation may worsen the adjacent lung injury even after adapting protective ventilation. Primary outcome: To evaluate the failure rate of weaning from IMV and its relationship with the lower and upper extremes of respiratory effort and the upper extreme of dynamic pulmonary stress during the first 7 days of spontaneous ventilation. Analyze the influence of these extremes based on the thresholds of Pocc, P0.1 and their derivatives Pmus, Ptp, din and MP: in relation to days off MV (in the 28-day interval); Total weaning time; Rate and time for tracheostomy; Length of stay in the ICU and hospital; In-hospital mortality rate. CAAE: 78185823.4.0000.5249. Prospective multicenter observational study, carried out in the ICUs of Glória D'or and Niteroi D'or hospitals, from January 2024 to July 2026, in patients over 18 years old, undergoing orotracheal intubation and IMV, in their first 7 days on spontaneous ventilation. Hypothesis: Extremes of respiratory effort and dynamic pulmonary stress would be associated with a higher rate of weaning from IMV, as well as longer time on IMV and subsequent longer hospital stay.",[226,227],"Mechanical Ventilation Pressure High","Weaning Failure",[229,230],"respiratory drive","respiratory effort","2024-07-19",{"date":233,"type":36},"2024-07-23",{"date":235,"type":36},"2024-04-01",{"date":237,"type":21},"2026-07",{"name":42,"class":43},""]