[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidade da Coruña\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":249},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,59,93,147,173,200],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100640586","effects-of-transcutaneous-vagus-nerve-stimulation-in-parkinsons-disease-100640586",false,"NCT07588191","Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease","Effects of Transcutaneous Stimulation of the Auricular Branch of the Vagus Nerve in Parkinson´s Disease","tVNS_PD","Inclusion Criteria:\n\n* Being a member of the Association or be interested in joining;\n* Idiopathic PD diagnosis, stages 2-3 according to the Hoehn \\& Yahr scale; confirmed by neurologist\n* Ability to walk independently for at least 1 minute ant turn 180° without assistance;\n* Exhibiting symptoms of hypokinetic dysarthria;\n* On stable dopaminergic therapy for at least 1 month prior to the experiment\n\nExclusion Criteria:\n\n* Any contraindication for taVNS (e.g., ear lesions, pacemakers, defibrillators, or other electronic devices)\n* Previous vagotomy or previous application of electrical stimulation to the ear or brain, or treatment with high-intensity focused ultrasound (HIFU)\n* Voice or speech disorders caused by other medical conditions\n* MoCA score below 21\n* Psychotic symptoms or hallucinations; a diagnosis of psychiatric illness\n* Systolic blood pressure above 160 mm Hg, and diastolic blood pressure above 100 mm Hg\n* Inability to attend sessions;\n* Concomitant neurological, orthopaedic, cardiac, respiratory or active medical\u002Foncological condition that would affect participation","ALL",{"count":19,"type":20},46,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to determine whether electrical stimulation of the ear, when combined with physical and speech therapy, can improve symptoms in subjects diagnosed with Parkinson´s disease, by comparing two different application sites.\n\nEach subject will undergo an initial in-person screening and provide consent before participating in the study.\n\nThe main questions to answer are:\n\n* Does transcutaneous electrical nerve stimulation (tVNS) in the ear paired with physical and speech therapy improve speech and voice-related problems, airway protection, salivation, and swallowing?\n* Does tVNS paired with physical and speech therapy improve tremor, walking speed, and balance in people with PD?\n* Does tVNS paired with physical and speech therapy improve heart rate and heart rate variability in people with PD?\n* Do its effects persist at 8 weeks?\n\nParticipants will:\n\nAttend 12 rehabilitation sessions over 4 weeks (three per week). During each session, participants received either active or sham tVNS, accompanied by speech therapy (once per week), physical therapy (once per week), or conducted alone (once per week).\n\nUndergo speech, voice, swallowing, respiratory, gait, balance, tremor, heart rate variability, and cognitive testing, as well as questionnaires regarding the quality of life, before and after treatment.\n\nReturn for a follow-up visit eight weeks after therapy to check how long the effects last.",[26,27],"Transcutaneous Vagal Nerve Stimulation (tVNS)","Parkinson Disease (PD)",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45],"transcutaneous electrical nerve stimulation","Vagus Nerve","Parkinson Disease","Speech Therapy","Physical Therapy Modalities","Deglutition","Tremor","Posture","Gait","Quality of Life","cognition","cough","Sialorrhea","Xerostomia","Heart Rate","voice disorders","Ear","RECRUITING","2026-05-15",{"date":49,"type":50},"2026-05-19","ACTUAL",{"date":52,"type":20},"2026-05",{"date":54,"type":20},"2026-11",{"name":56,"class":57},"Universidade da Coruña","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":21,"phases":73,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":58},"100621958","cardiometabolic-adaptations-to-concurrent-training-effect-of-effort-configuration-on-postmenopausal-women-100621958","NCT07377383","Cardiometabolic Adaptations to Concurrent Training: Effect of Effort Configuration on Postmenopausal Women","Cardiometabolic Adaptations to Resistance and Endurance Exercise: Effects of Effort Configuration in Concurrent Training for Postmenopausal Women","CARE+E","Inclusion Criteria:\n\n* At least one year since the last menstrual period.\n* Physically active, defined as engaging in 150-300 minutes of moderate physical activity per week or at least 75 minutes of vigorous activity per week.\n* Three or fewer traditional cardiovascular risk factors.\n* Asymptomatic and without cardiovascular (except controlled hypertension), metabolic, or renal diseases.\n* In the case of hypertensive participants, well-controlled grade 1 hypertension managed with a single medication.\n\nExclusion Criteria:\n\n* Diagnosis of grade 2 or grade 3 hypertension.\n* Hypertension managed with more than one medication or with a drug that could interfere with cardiovascular responses to exercise (e.g., beta-blockers).\n* Current or prior use of hormone replacement therapy.\n* Hypertensive response to exercise.",true,"FEMALE","46 Years","65 Years",{"count":72,"type":20},60,[23],"The main objectives of this project are to assess the effects of a 20-week concurrent training program on neuromuscular adaptations, body composition, cardiometabolic health, quality of life, mood state, physical self-perception, and menopause-related symptoms in physically active postmenopausal women, and to compare the adaptations resulting from different combinations of endurance and resistance training programs with varying effort configurations.\n\nAdditionally, this project aims to examine the longitudinal interaction and potential interference effects between endurance and resistance training effort configurations throughout the training program and to determine the optimal combination of effort configurations that maximizes health benefits in concurrent training programs for physically active postmenopausal women.",[76,77],"Postmenopausal","Hypertension",[79,80,81,82,83,84],"postmenopausal women","cardiovascular adaptations","concurrent training","resistance training","endurance training","interference phenomenon","2026-04-27",{"date":87,"type":50},"2026-04-28",{"date":89,"type":20},"2026-05-05",{"date":91,"type":20},"2028-12",{"name":56,"class":57},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":17,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":137,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":146},"100614095","acute-cardiovascular-and-neuromuscular-responses-to-walking-with-blood-flow-restriction-bfr-in-older-adults-100614095","NCT07275138","Acute Cardiovascular and Neuromuscular Responses to Walking With Blood Flow Restriction (BFR) in Older Adults","Acute Cardiovascular and Neuromuscular Responses to Walking With Blood Flow Restriction in Older Adults: a Study Protocol for a Randomized Crossover Trial","Inclusion Criteria:\n\n• Aged between 60 and 90 years.\n\nExclusion Criteria:\n\n* Being institutionalized.\n* Peripheral vascular disease, defined by an ankle-brachial index (ABI) outside the normal range (0.9-1.4).\n* Uncontrolled arterial hypertension (\\>180\u002F110 mmHg).\n* Any contraindication to exercise, based on self-reported medical history and PAR-Q+.","60 Years","90 Years",{"count":103,"type":20},20,[23],"The goal of this clinical trial is to explore how walking combined with different levels of partial blood flow restriction (BFR) affects cardiovascular, neuromuscular, and movement (kinematic) variables in older adults.\n\nThe main questions it aims to answer are:\n\nDoes walking with BFR increase internal effort, as shown by cardiovascular changes, and is this effect proportional to the level of restriction?\n\nDoes walking with BFR temporarily reduce neuromuscular control, and is this reduction greater at higher restriction levels?\n\nDoes walking with BFR change gait movement patterns?\n\nThis study uses a crossover design, meaning that each participant will complete all four conditions and serve as their own control.\n\nParticipants will:\n\nTake part in walking sessions under four conditions with different levels of restriction: BFR40%, BFR80%, SHAM (0% BFR), and CON (without BFR).\n\nHave their cardiovascular responses, muscle performance, and gait movement patterns measured.\n\nReport their perceptions of the sessions, including Rate of Perceived Exertion (RPE), satisfaction, and possible side effects.",[107],"Healthy Older Adults",[109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136],"Blood Flow Restriction (BFR)","walking exercise","older adults","Gait Kinematic","Cardiovascular Response","Neuromuscular Performance","Crossover Study","Physical Function","safety","Endurance training","Low-impact exercise","Aerobic exercise","Physical activity","functionality","Elderly","Senior","Age 60+","Community-dwelling","Non-institutionalized","Partial Blood Flow Restriction","Limb Occlusion Training","Vascular Occlusion Training","KAATSU Training","Low-load resistance training with BFR","Occlusion exercise","walking","walking training","exercise training","NOT_YET_RECRUITING","2025-11-28",{"date":140,"type":50},"2025-12-10",{"date":142,"type":20},"2025-12-08",{"date":144,"type":20},"2026-01",{"name":56,"class":57},2,{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":17,"minAge":154,"maxAge":101,"enrollmentInfo":155,"targetDuration":4,"studyType":21,"phases":157,"briefSummary":158,"conditions":159,"keywords":161,"overallStatus":137,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":4},"100584889","exercise-and-physical-activity-in-adults-with-acquired-brain-injury-100584889","NCT06895226","Exercise and Physical Activity in Adults with Acquired Brain Injury","PA_ABI","Inclusion Criteria:\n\n* Aged more than 18 years of age and present a medical diagnosis of acquired brain injury.\n* Have the informed consent completed and signed\n* Present a state that allows following indications for the practice of exercise and physical activity.\n\nExclusion Criteria:\n\n* Have medical comorbidities that contraindicate the safe performance of the program (i.e., cardiac or respiratory instability, uncontrolled seizures).\n* Have additional disabling conditions, such as cognitive impairment and\u002For an inability to communicate with the researcher verbally, in writing, or through an emissary.","18 Years",{"count":156,"type":20},30,[23],"Exercise and physical activity in adults with acquired brain injury",[160],"Acquired Brain Injury",[162,163,164],"Acquired brain injury","physical activity","intervention","2025-03-24",{"date":167,"type":50},"2025-03-26",{"date":169,"type":20},"2025-04-01",{"date":171,"type":20},"2025-11-01",{"name":56,"class":57},{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":67,"sex":17,"minAge":100,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":21,"phases":182,"briefSummary":183,"conditions":184,"keywords":189,"overallStatus":137,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":4},"100543969","knee-osteoarthritis-motor-control-risk-of-falls-and-virtual-reality-100543969","NCT06362785","Knee Osteoarthritis, Motor Control, Risk of Falls and Virtual Reality","Study on the Relationship Between Knee Osteoarthritis, Motor Control and the Risk of Falls, and the Effectiveness of Virtual Reality in Managing It in Older People","Inclusion Criteria:\n\n* Age over 60 years.\n* Non-institutionalized individuals.\n* Subjects who wish and consent through informed consent to participate in the study.\n* Have the ability to walk independently (with or without assistive devices).\n* Diagnosis of primary knee osteoarthritis according to the clinical and radiological criteria of the American College of Rheumatology.\n* Specifically, for phase 1, subjects without a knee osteoarthritis diagnosis will also be included.\n\nExclusion Criteria:\n\n* History of significant previous traumas or surgeries to the spine, pelvis, or legs in the last 12 months.\n* Self-reported presence of dizziness, seizures, or epilepsy, aiming to prevent potential exacerbation of symptoms with VR.\n* Vestibular disorders (balance).\n* Neurological diseases, cardiovascular, or respiratory disorders affecting activity; as well as inflammatory or autoimmune diseases affecting the lower limb joints, and other forms of secondary osteoarthritis.\n* Diagnosis of a terminal illness or a health condition that prevents attendance.\n* To have a medical contraindication for exercise.\n* Body Mass Index (BMI) ≥ 40",{"count":181,"type":20},110,[23],"The goal of this clinical trial is to learn about knee osteoarthritis, functionality, and risk of falls in community-dwelling adults aged 60 years and older. The main questions it aims to answer are:\n\n* What are the characteristics of a community-dwelling population over 60 years and older in terms of knee osteoarthritis, functionality, and risk of falls?\n* Does an intervention with virtual reality lower knee osteoarthritis symptoms, raise functionality and prevent falls in community-dwelling adults aged 60 years and older, compared to a control group receiving conventional physiotherapy treatment based on therapeutic exercise?\n\nParticipants will:\n\n* Answer questionnaires.\n* Perform physical laboratory tests through a camera-based motion capture system.\n* Execute task-based exercises in a virtual environment through virtual reality.\n\nResearchers will compare community-dwelling adults aged 60 years and older who execute task based exercises in a virtual environment through virtual reality and community-dwelling adults aged 60 years and older receiving conventional physiotherapy treatment based on therapeutic exercise to see if virtual reality improves knee osteoarthritis symptoms, functionality, and lowers fall risk.",[185,186,187,188],"Knee Osteoarthritis","Task Performance and Analysis","Accidental Falls","Virtual Reality",[190,186,187,191,188],"Knee osteoarthritis","Aged","2025-03-12",{"date":194,"type":50},"2025-03-17",{"date":196,"type":20},"2025-05-01",{"date":198,"type":20},"2026-06-01",{"name":56,"class":57},{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":17,"minAge":208,"maxAge":209,"enrollmentInfo":210,"targetDuration":4,"studyType":21,"phases":212,"briefSummary":215,"conditions":216,"keywords":218,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":58},"100583162","phase-2-wereables-for-upper-limb-functionality-in-hemiparesis-100583162","NCT06872736","Wereables for Upper Limb Functionality in Hemiparesis","Innovative Use of Wereable Technology for Improving Functionality in Children with Unilateral Cerebral Palsy","WeFun","Inclusion Criteria:\n\n* Confirmed diagnosis of UCP.\n* Children aged between 3 and 8 years old.\n* Children rated on levels I to III on the Manual Ability Classification System (MACS).\n\nExclusion Criteria:\n\n* Botulinum toxin injection or surgical interventions in the upper limb within 6 months prior to study entry.\n* Medical complications non-controlled that would interfere with study participation (e.g., not controlled epilepsy).\n* Predominantly athetoid or dystonia movement patterns.\n* Insufficient cognitive level to follow instructions,\n* Non-corrected marked visual impairments.\n\nFamilies can be retired from the study after starting if:\n\n* Families don't assist or don't collaborate in the weekly sessions with the reference person.\n* Wearable activity if presumably lower than expected (few recordings of activity, \\\u003C20%).\n* Families don't provide feedback about daily sessions through the satisfaction system in the app\u002Fregistration sheet.","3 Years","8 Years",{"count":211,"type":20},40,[213,214],"PHASE2","PHASE3","The project is configured as a national interventional study that aims to determine the effectiveness of an intervention strategy using wearable technology, tailored to improve function (WeFun-wearable), on the spontaneous use of the affected upper extremity, activities of daily living and the participation in children with unilateral cerebral palsy.",[217],"Unilateral Cerebral Palsy",[219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241],"children","unilateral cerebral palsy","function","mobility","upper limb","weareable","technology","routines","family centered approach","activity","participation","family","developmental disregard","environmental enrichment","natural environment","quality of life","movement analysis","fatigue","upper extremity","family involvement in research","hemiparesis","cerebral palsy","early intervention","2025-03-07",{"date":192,"type":50},{"date":245,"type":50},"2024-06-07",{"date":247,"type":20},"2026-12-20",{"name":56,"class":57},""]