[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Université Libre de Bruxelles\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":246},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,50,79,104,137,165,195,224],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100637739","effects-of-whole-body-high-intensity-interval-training-on-fitness-in-overweight-adults-100637739",false,"NCT07582718","Effects of Whole-Body High-Intensity Interval Training on Fitness in Overweight Adults","Effects of a Whole-body High-intensity Interval Training on Cardiorespiratory Fitness, Musculoskeletal Fitness, Body Composition and Blood Parameters in Overweight Subjects","WB-HIIT","Inclusion Criteria:\n\n* Adults aged 18 to 55 years.\n* Body mass index (BMI) between 25 and 35 kg\u002Fm².\n* Able to provide written informed consent.\n* Able to safely participate in high-intensity interval training.\n* For participants with BMI \\> 30 kg\u002Fm²: medical clearance from their general practitioner.\n\nExclusion Criteria:\n\n* BMI \\\u003C 25 or \\> 35 kg\u002Fm².\n* Presence of any chronic medical condition other than overweight\u002Fobesity.\n* Known cardiovascular, metabolic, respiratory, or musculoskeletal disease that contraindicates high-intensity exercise.\n* Pregnancy.\n* Inability to perform exercise testing or complete the WB-HIIT program.\n* Any condition judged by investigators to interfere with participation or data interpretation.","ALL","18 Years","55 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate the effects of a supervised whole-body high-intensity interval training (WB-HIIT) program on physical fitness and health outcomes in adults with overweight and obesity. WB-HIIT is a practical and time-efficient training modality based on body-weight exercises performed at high intensity with short recovery intervals. It may offer an accessible approach for improving health in individuals with excess body weight.\n\nParticipants aged 18 to 55 years with a body mass index (BMI) between 25 and 35 kg\u002Fm² will take part in a supervised 10-week WB-HIIT program, performed in small groups and led by trained exercise professionals. Before and after the intervention, participants will undergo assessments including DXA-based body composition analysis, fasting blood sampling, muscular strength testing, a Chester step test, a maximal graded treadmill exercise test with gas-exchange analysis to determine VO₂peak, and functional evaluations (chair-stand, arm-curl, and 6-minute walk test). Physical activity and dietary intake will also be recorded.\n\nThe primary objective of the study is to assess whether WB-HIIT improves cardiorespiratory fitness (VO₂peak) in adults with overweight. Secondary objectives include evaluating changes in muscular strength, body composition, metabolic markers, and functional capacity.\n\nThe results may help determine whether an equipment-free WB-HIIT program can serve as an effective and accessible training approach for improving health and physical fitness in adults with overweight and obesity.",[28],"Overweight and\u002For Obesity",[30,31,32,33,34,35,36],"Overweight","Cardiorespiratory Fitness","Body Composition","Muscular Strength","Whole-Body HIIT","Body-Weight Exercise","Metabolic health","RECRUITING","2026-05-11",{"date":40,"type":41},"2026-05-13","ACTUAL",{"date":43,"type":41},"2022-11-09",{"date":45,"type":22},"2026-06",{"name":47,"class":48},"Université Libre de Bruxelles","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":49},"100538094","aortopathy-relationship-to-imagery-and-kinocardiography-features-artik-100538094","NCT06286358","Aortopathy Relationship To Imagery and Kinocardiography Features (ARTIK)","Impact of Aortic Valve Disease and Thoracic Aortic Aneurysm on Kinocardiographic Signals","ARTIK","Inclusion Criteria\n\n* \"Interventional treatment\" group\n\n  * Adults (\\>18 y)\n  * Interventional treatment indication for severe AVD and\u002For severe TAA, as decided by the Heart Team\n* \"Aortic valve disease of different severities\" group\n\n  * Adults (\\>18y)\n  * Aortic stenosis and\u002For aortic regurgitation and\u002For bicuspidy of different severities confirmed by echocardiography and\u002For cardiac MRI\n* \"Control\" group : - Adults (\\>18 y) appariated with the participants of other groups according to their age, sex, body surface area and LVEF\n\nExclusion Criteria:\n\n* Any severe rhythm disorder such as frequent ventricular extrasystoles, atrial tachyarrhythmias\n* Subject's disabilty to give consent\n* Subjects suffering from aortic valve disease or thoracic aortic aneurysm will be excluded from the \"control\" group.",true,{"count":60,"type":22},180,"OBSERVATIONAL","Kinocardiography (KCG) is a portable measurement technique developed to estimate cardiac mechanical performance by studying the vibrations produced by myocardial contraction during each heartbeat and transmitted to the body surface.\n\nThe goal of this observational study is to learn about kinocardiography in patients with aortic valve disease (AVD) or thoracic aortic aneurysm (TAA). The investigators believe that this technology will enable to diagnose aortic valve disease and aortic aneurysm.\n\nIn patients with AVD of different severities or TAA, the investigators will collect informations from echocardiography and\u002For cardiac magnetic resonance imaging, KCG recordings, phonocardiography (PCG) recordings, and video recordings. Researchers will also compare subjects without any AVD nor TAA to better understand these effects on KCG, PCG and video signal.",[64,65],"Aortic Valve Disease","Aortic Aneurysm",[67,68,69,70],"Aortic stenosis","Aortic regurgitation","Thoracic aortic aneurysm","Kinocardiography","2026-04-27",{"date":73,"type":41},"2026-05-01",{"date":75,"type":41},"2024-03-07",{"date":77,"type":22},"2026-12-30",{"name":47,"class":48},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":49},"100632460","objective-measurement-of-the-mechanical-pain-threshold-with-an-algometer-for-predicting-intraoperative-opioid-consumption-in-patients-who-will-be-operate-by-thoracotomy-and-sternotomy-in-cardiac-surgery-100632460","NCT07513974","Objective Measurement of the Mechanical Pain Threshold With an Algometer for Predicting Intraoperative Opioid Consumption in Patients Who Will be Operate by Thoracotomy and Sternotomy in Cardiac Surgery","The Usefulness of Preoperative Measurement of the Mechanical Pain Threshold for Predicting Intraoperative Opioid Consumption","Inclusion Criteria:\n\n* ASA 3 patients with scheduled cardiac surgery by thoracotomy or sternotomy\n\nExclusion Criteria:\n\n* Patient refusal,\n* A body mass index (BMI) \\> 30 kg\u002Fm²,\n* Allergies to any medication used in typical cardiac anesthesia,\n* Chronic pain or regular use of analgesics,\n* Severe ventricular dysfunction, pulmonary hypertension, poorly controlled arhythmia,\n* Non-elective surgery.\n* Patients enrolled in another study protocol within the previous 3 months,\n* Pregnant or breastfeeding patients,\n* Patients with severe renal or hepatic impairment.\n* Patients for whom the study will be stopped in the event of blood loss greater than or equal to one liter, or for any other severe perioperative surgical complication.",{"count":87,"type":22},100,[25],"The study aims to test the relationship between the preoperative pain threshold and the intraoperative need for opioids.\n\nThe objective of the study is to try to predict a patient's analgesic needs based on their objectively determined preoperative pain threshold.\n\nThe investigators will include patients scheduled for elective cardiovascular surgery.\n\nThe investigators will investigate the correlation between the preoperative pain threshold and intraoperative\u002Fpostoperative opioid consumption in a highly standardized anesthesia setting.",[91],"Cardiac Surgery Subjects",[93,94,95],"pain threshold","intra operative opioid consumption","algometer","2026-04-04",{"date":98,"type":41},"2026-04-07",{"date":100,"type":41},"2026-01-24",{"date":102,"type":22},"2026-12-15",{"name":47,"class":48},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":122,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":49},"100619222","parental-support-intervention-in-an-advanced-oncological-context-100619222","NCT07341815","Parental Support Intervention in an Advanced Oncological Context","Efficacy of a Parental Support Intervention to Improve Communication of Advanced Cancer Patients With Adolescents and Young Adults","Inclusion Criteria:\n\n* Metastatic cancer, recurrence of cancer or certain types of hematological cancer (chronic disease, acute leukemia, multiple myeloma or lymphoma recurrence)\n* Have at least one child aged between 10 and 25 years\n* Wish to benefit from a psychological intervention about communication with their children about cancer or its consequences\n* Able to read and speak French\n* Accept to give their written informed consent\n\nExclusion Criteria:\n\n* Severe neurological disorder\n* Severe psychiatric disorder\n* (Pre-)terminal phase of cancer disease",{"count":112,"type":22},120,[25],"This prospective, two-arm randomized trial compares a psycho-educational program to a psycho-educational and experiential program for parents with advanced cancer. These two interventions aim to support parent-child communication about cancer, but we hypothesize that the combined intervention will be more effective for all studied communication variables.",[116,117,118,119,120,121],"Metastatic Cancer","Cancer Recurrence","Hematological Cancer","Parent-Child Relations","Parenting","Communication",[123,124,125,126,127,128],"Parental cancer","Parent-child communication","Parenting intervention","Advanced cancer","Adolescent Young Adult (AYA)","Uncertainty","2026-01-07",{"date":131,"type":41},"2026-01-14",{"date":133,"type":41},"2022-05-27",{"date":135,"type":22},"2026-12",{"name":47,"class":48},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":23,"phases":146,"briefSummary":147,"conditions":148,"keywords":151,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":161,"leadSponsor":163,"locationsCount":164},"100611087","e-motion--promoting-emotion-regulation-in-chronic-cancer-100611087","NCT07236021","e-Motion : Promoting Emotion Regulation in Chronic Cancer","Promoting Emotion Regulation in Patients Living With Chronic Cancer : A Pilot Feasibility, Acceptability and Tolerability Study (e-Motion Project)","Inclusion Criteria:\n\n* Having received a diagnosis of chronic cancer (metastatic breast cancer, metastatic melanoma, metastatic colorectal, metastatic ovarian, metastatic uterine, metastatic endometrial, metastatic prostate, metastatic bladder, metastatic kidney or metastatic testicular cancer, symptomatic multiple myeloma, metastatic non-small cell lung, metastatic mesothelioma or metastatic thymoma) in the past 12 months,\n* Having completed at least one active treatment session (e.g., chemotherapy, surgery, radiotherapy, immunotherapy, target therapy).\n\nExclusion Criteria:\n\n* Having less than one year of life expectancy\n* Having more than one treatment line (for triple negative breast cancer, melanoma, gynecological cancer, colorectal cancer, bladder cancer, kidney cancer, non-small cell lung, mesothelioma and thymoma) or two treatment lines (for other breast cancers and testicular cancer) or three treatment lines (for prostate cancer and multiple myeloma),\n* Having a diagnosis of oligometastatic cancer,\n* Age \\\u003C 18 years,\n* Non-fluency in French,\n* Inability to follow the online intervention,\n* Severe cognitive impairment, and severe and\u002For acute psychiatric disorder.",{"count":145,"type":22},30,[25],"The present study aimed to pilot evaluate two interventions: a Guided Self-Help Intervention alone, and a combined Group and Guided Self-Help Intervention, designed to support individuals living with chronic cancer and recently diagnosed. The primary aim of this pilot study is to assess the feasibility, acceptability and tolerability of the interventions. The secondary aim of the pilot study is to assess the interventions preliminary efficacy and differences on psychological symptoms.",[149,150],"Metastatic Cancers","Myeloma Multiple",[126,152,153,154,155,156],"Cognitive Behavioral Therapy (CBT)","Emotional regulation","Ecological Momentary Assessment (EMA)","Hypnosis","Psychotherapy Group","2025-11-20",{"date":159,"type":41},"2025-11-21",{"date":157,"type":41},{"date":162,"type":22},"2026-12-31",{"name":47,"class":48},2,{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":175,"briefSummary":176,"conditions":177,"keywords":182,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":49},"100589796","impact-of-intermittent-fasting-on-sleep-and-quality-of-life-100589796","NCT06959069","Impact of Intermittent Fasting on Sleep and Quality of Life","Impact of Intermittent Fasting on Sleep and Quality of Life Among Healthy Adults","Inclusion Criteria:\n\n* Healthy subjects\n* Adult subjects - age: between 18 and 65 years old\n* Subjects with a BMI between 18.5 and 29.9 kg\u002Fm\\^2\n* Male and female subjects\n\nExclusion Criteria:\n\n* Subjects \\\u003C 18 years old\n* Subjects with Diabetes Mellitus (type 1 and type 2)\n* Pregnant and\u002For breastfeeding and\u002For postpartum women\n* Underweight subjects (BMI \\\u003C 18.5)\n* Obese subjects (BMI \\> 30)\n* Subjects with confirmed sleep disorders (requiring CPAP or sleep medication (sleeping pills))\n* Subjects with renal failure (GFR \\\u003C 30 ml\u002Fmin\u002F1.73 m\\^2) or liver disorder\n* Subjects with serious cardiovascular, respiratory, neurological, or metabolic medical conditions\n* Subjects with malignant tumors\n* Subjects with a serious mental disorder requiring medication (e.g., antidepressants or anxiolytics)\n* Subjects with eating disorders\n* Subjects who have undergone major surgery or have been hospitalized due to major medical condition (surgery, stay in intensive care) within the last one year\n* Subjects who have lost more than 10% of their body weight within the last one year\n* Subjects actively participating in a weight-loss program\n* Subjects with alcohol use disorder (maximum 10 standard alcoholic drinks per week, 2 standard alcoholic drinks per day)\n* Subjects with substance use disorder\n* Subjects unable to provide informed consent\n* Subjects who do not participate simultaneously in another clinical trial","65 Years",{"count":174,"type":22},36,[25],"The goal of this clinical trial is to investigate the impact of intermittent fasting on sleep, quality of life and fatigue among healthy volunteers. The main questions aim to answer:\n\nWhether intermittent fasting would allow participants to experience an improvement in their sleep quality, duration and latency? Whether intermittent fasting would ameliorate participants' quality of life and reduce chronic fatigue symptoms? Researchers will compare the two most prevailing fasting windows of intermittent diet including an early morning feeding window (8 a.m.-4 p.m.) and a late feeding window (12 p.m.-8 p.m.) to see if there is a difference among these feeding windows on sleep and quality of life.\n\nParticipants will:\n\n* Be divided into two groups (group A and group B) that will alternate their fasting windows.\n* Group A will start with intermittent fasting over a feeding period from 12 p.m. to 8 p.m. for one month, then a two weeks period of usual eating habits (washout period) and finally one month of intermittent fasting with a feeding period from 8 a.m. to 4 p.m.\n* Group B will follow intermittent fasting over a feeding period from 8 a.m. to 4 p.m for one month, then a two weeks period of usual eating habits (washout period) and finally one month of intermittent fasting with a feeding period from 12 p.m. to 8 p.m.\n* At enrollment, at the end of each month of intermittent fasting and at the end of washout period participants will be asked to complete some questionnaires and will be submitted to anthropometric measurements using impedance scales.\n* Participants will be asked to complete an electronic 24 hour recall diary using the Automated Self-Administered 24h Dietary Assessment (ASA24) Tool software once per week every week during study.",[178,179,180,181],"Sleep Quality","Quality of Life","Fatigue","Intermittent Fasting",[183,184,185,186],"intermittent fasting","sleep","quality of life","fatigue","2025-04-27",{"date":189,"type":41},"2025-05-06",{"date":191,"type":41},"2025-03-17",{"date":193,"type":22},"2026-08-30",{"name":47,"class":48},{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":201,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":203,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":23,"phases":206,"briefSummary":207,"conditions":208,"keywords":210,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":4},"100567277","effects-of-n3-lc-pufas-on-inflammatory-immune-and-senescence-features-in-polyvascular-older-subjects-omsage-100567277","NCT06666101","Effects of n3 LC PUFAs on Inflammatory, Immune and Senescence Features in Polyvascular Older Subjects (OMSAGE)","Immunomodulatory Effects of Polyunsaturated ω-3 Fatty Acids in Old Patients With Polyvascular Disease: a Double-blind, Randomized, Controlled, Factorial 2x2 Trial (\"OMEGA3\" Study)","OMSAGE","Inclusion Criteria:\n\n* ≥ 75 years old\n* Patients with polyvascular disease in cases of vascular lesions in ≥2 disease territories or any combination of coronary, peripheral, or carotid artery disease.\n* Able to comply with the requirements of the study protocol\n* Signed informed consent form approved by the ethical committee\n* No illness or event within 2 months prior to inclusion (hospitalization, trauma, active cancer, infection, acute failure of chronic disease, surgical intervention)\n* No history of multiple and\u002For severe allergies to drugs or foods\n* No consumption of fish oil or omega-3 fatty acid supplements within 2 months prior to inclusion\n* No consumption of more than 500 mg\u002Fday of dietary omega-3 fatty acids (questionnaire)\n* No intake of anti-inflammatory or corticosteroid medication within 2 weeks prior to inclusion\n* Able and authorized to take a pill\n* No intervention planned in the months following the start of the study\n\nExclusion Criteria:\n\n* Inflammatory syndrome (CRP \\>10 mg\u002Fl) on day 0 and day 7\n* Acute illness or event during the time of intervention","75 Years",{"count":205,"type":22},80,[25],"The objectives is to evaluate the effect of omega-3 fatty acids in old participants with polyvascular disease on immune parameters and inflammatory mediators at different times. Three modalities of administration of omega-3 will be compared with a placebo (olive oil): predominant EPA (Eicosapentaenoic acid), predominant DHA (doxosahexaenoic acid), and combinaison of both. This study will measure the level of omega3 fatty acids in this population 4 hours after taking, on the 7th day, on the 21th day of administration and 1 month after administration.",[209],"Polyvascular Disease",[211,212,213,214],"fatty acid, omega 3","immune response","inflammatory mediators","macrophage polarisation","NOT_YET_RECRUITING","2024-10-28",{"date":218,"type":41},"2024-10-30",{"date":220,"type":22},"2024-11-04",{"date":222,"type":22},"2025-12-31",{"name":47,"class":48},{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":58,"sex":17,"minAge":4,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":23,"phases":233,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":164},"100547588","phase-1-comparison-of-skeletal-effects-of-herbst-and-invisalign-ma-in-growing-patients-with-klass-ii-malocclusion-100547588","NCT06409923","Comparison of Skeletal Effects of Herbst and Invisalign MA in Growing Patients With KLass II Malocclusion","Comparison of Skeletal Effects of Herbst and Invisalign MA in Growing Patients With KLass Malocclusion","Inclusion Criteria\n\n* ANB greater than 4°.\n* Angle Class II molar and canine relationship\n* cervical vertebral maturation (CVM) CVM2\u002FCVM3\n\nExclusion Criteria:\n\n* CVM\\> 4\n* periodontal disease","15 Years",{"count":145,"type":22},[234],"PHASE1","This study aims to determine and compare the precise skeletal dental and soft tissue effect of Mandibular advancement aligners and Herbst Appliance.",[237],"Mandibular Growth Stimulation","2024-05-07",{"date":240,"type":41},"2024-05-10",{"date":242,"type":41},"2024-02-14",{"date":244,"type":22},"2027-09-10",{"name":47,"class":48},""]