[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Université de Nantes\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100627561","measurement-of-pro-resolving-inflammation-biomarkers-in-saliva-gingival-fluid-and-dental-pulp-in-patients-with-symptomatic-pulpitis-and-healthy-controls-100627561",false,"NCT07450235","Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy Controls","Strategic Inflammation Modulation and Advanced Regenerative Therapy of Dental PULP","SMART-PULP","Inclusion criteria\n\n* Age ≥ 18 years, male or female.\n* Patient consulting for symptomatic pulpitis (confirmed clinical and radiographic diagnosis) or for wisdom tooth extraction (healthy subject).\n* Patient able to understand the research and having signed a written consent form.\n* Permanent teeth only.\n\nExclusion criteria\n\n* Refusal to participate.\n* Pregnancy or breastfeeding.\n* Antibiotic or anti-inflammatory treatment in the week prior to sampling.\n* Clinically diagnosed inflammatory gingival or periodontal disease (gingivitis or periodontitis)\n* Chronic systemic inflammatory disease (e.g., uncontrolled diabetes, autoimmune diseases).\n* Patients under guardianship, conservatorship, or legal protection","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","3 Years","OBSERVATIONAL","This observational study aims to better understand inflammation inside the dental pulp (the inner tissue of the tooth) in patients with symptomatic pulpitis compared with healthy individuals.\n\nResearchers will measure inflammation-related biomarkers in saliva, gingival fluid, and dental pulp samples to determine whether these substances reflect the level of inflammation.\n\nThe study also evaluates whether saliva and oral fluids could be used as simple, non-invasive tools to detect and monitor pulp inflammation.\n\nWe hypothesize that patients with pulpitis will show different biomarker levels compared with healthy controls.",[26,27],"Pulpitis","Healthy","NOT_YET_RECRUITING","2026-02-26",{"date":31,"type":32},"2026-03-04","ACTUAL",{"date":34,"type":21},"2026-03-01",{"date":36,"type":21},"2028-12",{"name":38,"class":39},"Université de Nantes","OTHER",""]