[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Université du Québec à Trois-Rivières\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":168},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,73,106,136],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100626822","the-count-me-in-program-in-support-of-social-participation-for-older-people-with-loss-of-autonomy-100626822",false,"NCT07440628","The Count Me In Program in Support of Social Participation for Older People With Loss of Autonomy","The Count Me In Program in Support of Social Participation for Seniors Residing in Long-term Care Facilities and Seniors With Loss of Autonomy in Day Centres","Inclusion Criteria:\n\n* Must be over 55 years old\n* Must be able to understand and speak French fluently\n* Must be able to attend a group meeting lasting about 45 minutes\n* Must currently participate in at least one leisure activity in a day centre\n\nExclusion Criteria:\n\n* None","ALL","55 Years",{"count":19,"type":20},8,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this observational study is to determine whether the Count Me In Program (Participe-Présent in French), which focuses on the strengths and power to act of older adults, can improve social participation and psychosocial factors among older adults with loss of autonomy, as assessed by the following outcome measures: (1) loneliness; (2) depressive symptoms; (3) cognition; (4) frequency of participation in leisure activities; and (5) type of social participation.\n\nParticipants will attend seven weekly workshops in the Count Me In Program.",[26,27],"Older Adults","Loss of Autonomy",[29,30,31],"Older adults","Loss of autonomy","Day centre","NOT_YET_RECRUITING","2026-02-25",{"date":35,"type":36},"2026-02-27","ACTUAL",{"date":38,"type":20},"2026-04-01",{"date":40,"type":20},"2026-06-01",{"name":42,"class":43},"Université du Québec à Trois-Rivières","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},"100590058","randomized-controlled-trial-of-custom-foot-orthoses-for-chronic-forefoot-pain-100590058","NCT06962475","Randomized Controlled Trial of Custom Foot Orthoses for Chronic Forefoot Pain","A Participant- and Assessor-blinded Superiority Randomized Controlled Trial of Custom Foot Orthoses for Chronic Metatarsalgia","Inclusion Criteria:\n\n1. are aged 18 years or over,\n2. have bilateral or unilateral metatarsalgia under one or more of the lesser metatarsal heads for at least 3 months (pain score of ≥ 4 out of 10 on a Visual Analogue Scale (VAS)) that is aggravated by weight-bearing activities,\n3. are able to walk without assistive devices (e.g., cane, walker),\n4. are willing to wear shoes that will accommodate their FOs on a daily basis and\n5. are willing to minimize the use of other interventions (e.g., pain medications, physical therapy) during the trial period\n\nExclusion Criteria:\n\n1. have arthritis,\n2. have neurological diseases (e.g., intermetatarsal neuroma) or other mechanical pain, plantar corns (e.g., intractable plantar keratoma),\n3. have a history of orthopedic foot surgery,\n4. have prior use of customized FOs,\n5. have cognitive impairments,\n6. are pregnant.","18 Years",{"count":53,"type":20},64,[23],"Background Chronic metatarsalgia (CM) causes significant pain and disability, affecting quality of life. Foot orthoses (FOs) including medially wedged designs with a metatarsal pad decrease excessive plantar pressure under the metatarsal heads, which is a suggested risk factor for developing CM. This FOs model may be effective in diminishing pain and improving function in these individuals. Thus, the objective of this trial will be to compare the effects of medially wedged FOs with a metatarsal pad and sham FOs on pain and foot function in individuals with CM.\n\nMethods\u002Fdesign This participant- and assessor-blinded superiority randomized controlled trial (RCT) with two parallel groups will be conducted in Trois-Rivières, Canada. Sixty-four participants with CM will be recruited from the Université du Québec à Trois-Rivières outpatient podiatry clinic and via social media invitations. They will be randomized into intervention (customized FOs) or control (sham FOs) groups and will be evaluated at baseline and after 6 and 12 weeks. The primary outcome will be: (1) mean pain during walking for the most painful foot during the past week. The secondary outcomes will be: (1) Foot Function Index, (2) Global rating of change and (3) the 5-level EQ-5D.\n\nDiscussion Medially wedged FOs with a metatarsal pad are expected to provide a greater reduction in pain and improvement in foot function compared to sham FOs. This trial will help guide FOs prescription recommendations for managing foot pain in individuals with CM in the future.",[57],"Metatarsalgia",[59,57,60,61,62],"RCT","Foot Orthoses","Sham","Customized","RECRUITING","2026-02-06",{"date":66,"type":36},"2026-02-10",{"date":68,"type":36},"2025-02-01",{"date":70,"type":20},"2027-08-01",{"name":42,"class":43},1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},"100546926","phase-2-corticosteroid-against-saline-injections-for-thumb-osteoarthritis-casitoa-100546926","NCT06401317","Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA)","Comparison of the Efficacy of Intra-Articular Corticosteroid Injections Versus Saline Solution for Thumb Osteoarthritis: Double-Blind Pragmatic Randomized Pilot Study","CASITOA","Inclusion Criteria:\n\n* aged ≥18 years;\n* diagnosis of TMO was confirmed by X-ray interpreted by a radiologist;\n* suffering from pain at the base of the thumb;\n* the attending physician deems that an intra-articular corticosteroid injection would be beneficial, rather than opting for other types of intervention such as surgery\n* can read, understand and answer in either French or English.\n\nExclusion Criteria:\n\n* having received one or more corticosteroid injections in the last 12 months or surgery on the affected thumb;\n* suffering from painful thumb caused by a trauma (e.g., fracture, sprain), rheumatoid arthritis, or De Quervain's tendonitis; and\n* being pregnant or breastfeeding; and\n* known allergies to any components of the solutions (triamcinolone acetonide, benzyl alcohol, carboxymethylcellulose sodium, hydrochloric acid, polysorbate, sodium chloride, or sodium hydroxide) or to iodinated contrast media.",{"count":82,"type":20},40,[84],"PHASE2","Thumb osteoarthritis or trapeziometacarpal osteoarthritis (TMO) is a common and painful form of hand arthritis that limits thumb mobility and hand function, affecting patients' quality of life. Although corticosteroids injections are a typical treatment, their effectiveness has been challenged, and side effects have been reported. Recent studies suggest that saline injections, usually considered inactive, might be a viable treatment option. The primary goal of this study is to compare the effectiveness of saline injections versus corticosteroids injections in reducing TMO-related pain and improving hand function. In this study, 40 people with TMO will be randomly assigned to receive either a corticosteroids or a saline injection, without them or the doctors performing the injection knowing which one was administered (double blind). If saline injections prove more effective, they could provide a less harmful and cheaper therapeutic alternative for TMO patients.",[87],"Trapeziometacarpal Osteoarthritis",[89,90,91,92,93,94,95,96],"Corticosteroids","Feasibility","Blinding","Randomized controlled trial","Saline","Trapeziometacarpal osteoarthritis","Intra-articular injection","Pragmatic trial","2026-01-20",{"date":99,"type":36},"2026-01-22",{"date":101,"type":36},"2025-11-04",{"date":103,"type":20},"2028-12-31",{"name":42,"class":43},2,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":21,"phases":116,"briefSummary":117,"conditions":118,"keywords":124,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":72},"100468805","olfactory-training-as-a-treatment-for-olfactory-dysfunction-post-covid-19-100468805","NCT05384561","Olfactory Training As a Treatment for Olfactory Dysfunction Post COVID-19","L'entraînement Olfactif Comme Traitement De La Dysfonction Olfactive Post COVID-19","OTTODC19","Inclusion Criteria:\n\n* Patient diagnosed positive for COVID-19 with persistent olfactory dysfunction\n* Willing and able to provide written informed consent\n* Understand and read the French language\n* Have an internet connection and a working email address\n\nExclusion Criteria:\n\n* Anosmia and hyposmia pre-covid-19\n* Be known chronic rhinosinusitis with or without nasal polyposis\n* Have received radiotherapy or chemotherapy for Head and Neck Tumors\n* Have a diagnosis of Alzheimer's, Parkinson's, multiple sclerosis or any other neurodegenerative disease 5. Have a brain tumor or ENT diagnosis 6. History of naso-sinus surgery; 7. History of traumatic brain injury",{"count":115,"type":20},70,[23],"Olfactory dysfunction is a defining symptom of COVID-19 infection. Studies have demonstrated improved olfaction in patients with post infectious olfactory dysfunction after an olfactory training (OT). The aim of this study is to assess the clinical outcomes of olfactory training (12 weeks) therapy in the treatment of persistent olfactory dysfunctions after COVID-19. Specially, we aim to compare the effectiveness of two different olfactory training (different odors).\n\nA group will train themselves with 4 scents (rose, orange, clove and eucalyptus) and another group with 4 different scents (cheese, coffee, strawberries and lemon). Olfaction sensory evaluation will be performed by using different olfaction tests (Sniffin' Sticks and UPSIT) and complete questionnaires to assess olfactory perception and particularly parosmia and phantosmia.",[119,120,121,122,123],"Hyposmia","COVID-19","Parosmia","Anosmia","SARS-CoV-2 Infection",[125,126,127],"Olfactory training","Chemosensory impairments","Persistent smell impairment","2024-12-11",{"date":130,"type":36},"2024-12-17",{"date":132,"type":36},"2022-05-31",{"date":134,"type":20},"2025-09",{"name":42,"class":43},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":144,"sex":16,"minAge":51,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":21,"phases":148,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":72},"100515043","the-metric-study-protocol-100515043","NCT05986370","The METRIC Study Protocol","The METRIC Study Protocol: an Explanatory Randomized Controlled Trial Investigating the Neurophysiological Mechanisms Underlying the Therapeutic Effects of Spinal Manipulative Therapy for Chronic Primary Low Back Pain","METRIC","Inclusion Criteria:\n\n* Duration of current low back pain (LBP) episode ≥ 6 months;\n* Average LBP intensity during the last 7 days ≥ 3\u002F10;\n* (For healthy volunteers only) To be of the same sex and age (± 1 year) as a participant with low back pain.\n\nExclusion Criteria:\n\n* Diagnosis of back conditions other than chronic primary LBP e.g., failed back surgery syndrome, spondylosis, spondylolisthesis, spinal stenosis, herniated disc, infection, etc.;\n* Presence of pain in another body location that is more severe than the pain in the lower back;\n* Presence of a neurological deficit i.e., sensation loss, muscle weakness, decreased deep tendon reflexes;\n* Presence of contraindications to spinal manipulative therapy e.g., recent fracture, history of spinal surgery, cauda equina syndrome, inflammatory arthritis, taking anticoagulant medication, active cancer, moderate to severe osteoporosis, abdominal aortic aneurysm;\n* Underwent surgery in the last 3 months;\n* Pregnancy, ≤ 3 months post-partum or planning to get pregnant in the next 12 months;\n* History of spinal manipulative therapy in the past 12 months;\n* Scoliosis ≥ 20°;\n* BMI ≥ 40;\n* Insufficient language skills in French to complete the questionnaires;\n* Open or pending litigation for LBP or seeking\u002Freceiving disability compensation;\n* Diagnosis of an illness affecting the sensorimotor functions e.g., diabetes, multiple sclerosis, amyotrophic lateral sclerosis;\n* Diagnosis of mental health disorders (with the exception of anxiety and depression);\n* Current drug or alcohol dependence;\n* Skin of type I on the Fitzpatrick scale;\n* (For healthy volunteers only) Regular use of pain medication or usage in the 48 h prior to data collection;\n* (For healthy volunteers only) History of chronic pain;\n* (For healthy volunteers only) Acute pain on the days of data collection.",true,"60 Years",{"count":147,"type":20},112,[23],"The goal of this clinical trial is to test the effects of spinal manipulative therapy in individuals with chronic primary low back pain and determine the neurophysiological mechanisms underlying pain relief. The main questions it aims to answer are: • Is pain relief produced by spinal manipulative therapy in patients with chronic primary low back pain caused by a reduction of C-fiber-related nociceptive processing? • Are these effects greater when spinal manipulative therapy is applied to the whole spine where it is clinically indicated compared with lumbar spine only? • Are these effects greater after 36 treatments over 3 months compared with 12 treatments over 1 month. Participants will receive spinal manipulative therapy (all clinically indicated spine segments or back only) or a control intervention. A group of healthy volunteers will be recruited to assess secondary outcome measures over the same time period, as reference data for comparisons. Researchers will compare the two groups receiving spinal manipulative therapy to the group receiving the control intervention to see if clinical pain relief and the reduction of temporal summation of second pain (produced experimentally) is significantly greater with spinal manipulative therapy.",[151],"Chronic Low-back Pain",[153,154,155,156,157,158,159],"chronic primary low back pain","spinal manipulative therapy","nociplastic pain","central sensitization","C-fibers","brain","electroencephalography","2023-12-01",{"date":162,"type":36},"2023-12-04",{"date":164,"type":36},"2023-10-25",{"date":166,"type":20},"2026-12-31",{"name":42,"class":43},""]