[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Université du Québec a Montréal\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":88},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100616722","psychosocial-factors-and-efficacy-of-remote-cognitive-remediation-for-post-traumatic-stress-disorder-100616722",false,"NCT07309302","Psychosocial Factors and Efficacy of Remote Cognitive Remediation for Post-Traumatic Stress Disorder","Psychosocial Determinants and Impact of a Synchronous Remote Cognitive Remediation Program on Individuals With Post-Traumatic Stress Disorder.","Inclusion Criteria\n\n* Age 18 to 45 years\n* Able to speak and read French fluently\n* Access to a computer with a camera and a secure Internet connection\n* Access to a private space for assessment and intervention sessions\n* Available for the complete treatment protocol\n* Confirmed current PTSD diagnosis using the Structured Clinical Interview for DSM-5 (SCID-5)\n* Residing in Canada\n\nExclusion Criteria\n\n* History of neurological disorders (stroke, intracranial surgery, aneurysm, epilepsy)\n* Moderate to severe traumatic brain injury OR hospitalization due to traumatic brain injury\n* Mild traumatic brain injury less than 6 months ago with persistent symptoms\n* Psychotic disorders\n* Alcohol abuse or substance dependence disorders\n* Video game addiction\n* Hospitalization for major depression or suicide risk within the past 3 months\n* Regular use of medications that impact neurocognition, including: benzodiazepines (diazepam, lorazepam, alprazolam, Ativan, Xanax, Rivotril)\n* Residence outside Canada","ALL","18 Years","45 Years",{"count":20,"type":21},64,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate whether computer-based brain training can help adults with post-traumatic stress disorder (PTSD). Individuals with PTSD often experience difficulties with memory, attention, concentration, and problem-solving, which can significantly affect their daily lives, work performance, and overall quality of life. These cognitive challenges can hinder trauma recovery and reduce the effectiveness of standard PTSD treatments.\n\nThe main questions this study seeks to address are:\n\nDoes specialized brain training improve PTSD symptoms compared to regular computer games? Does brain training enhance cognitive functions such as memory, attention, processing speed, and executive functioning? Does brain training improve quality of life and daily functioning? Do participants' self-efficacy and perceived social support influence treatment outcomes?\n\nResearchers will compare two approaches: a specialized cognitive training program (HAPPYneuron Pro) with strategy teachings and quality-of-life discussions, versus engaging computer games with quality-of-life discussions, to determine which is more effective for people with PTSD.\n\nStudy Design\n\nParticipants will be randomly assigned to one of two groups for an 8-week program:\n\nCognitive remediation training group: Complete computerized cognitive exercises and strategy teachings specifically designed to strengthen memory, attention, and executive functions, combined with quality-of-life discussions.\n\nControl group: Complete engaging computer games combined with quality-of-life discussions.\n\nSchedule\n\nBoth groups will follow the same schedule:\n\nOne online session per week, in small and consistent groups of 4-8 participants. Each 60-minute session consists of 30 minutes of computer activities followed by 45 minutes of group discussion.\n\nOne at-home individual homework exercise per week (30 minutes at home).\n\nTotal time commitment: 1h45 per week for 8 weeks.\n\nAssessments All participants will complete three comprehensive assessment sessions: before treatment, immediately after the 8-week program, and 3 months later. Assessments include neuropsychological testing and questionnaires on PTSD symptoms, depression, anxiety, quality of life, satisfaction with life, social support, cognitive failures, and self-efficacy.\n\nSignificance This research evaluates a new, accessible and remotely deliverable approach for PTSD treatment. Current evidence-based treatments often do not directly target the cognitive impairments experienced by many individuals with PTSD.\n\nCompensation Participants will receive $35 for each completed assessment (maximum $105). Control group participants will gain access to the cognitive remediation training program after completing their participation.",[27],"Post Traumatic Stress Disorder PTSD",[29,30,31,32,33,34,35,36,37,38,39,40,41],"Cognitive remediation","Social Support","Quality of Life","Online Intervention","Self-Efficacy","Depression","Anxiety","Attention","Verbal Memory","Executive Functions","Life Satisfaction","Post-Traumatic Stress Disorder","Neuropsychological functions","RECRUITING","2026-05-13",{"date":45,"type":46},"2026-05-18","ACTUAL",{"date":48,"type":46},"2025-08-03",{"date":50,"type":21},"2026-12",{"name":52,"class":53},"Université du Québec a Montréal","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":16,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":54},"100583247","cognitive-psychophysiological-treatment-for-tics-in-young-people-with-tourettes-syndrome-with-or-without-biofeedback-100583247","NCT06873841","Cognitive-psychophysiological Treatment for Tics in Young People With Tourette's Syndrome With or Without Biofeedback","Can the Cognitive-Psychophysiological Treatment of Tics be Optimized Through Biofeedback in Adolescents and Emerging Adults With Tourette Syndrome? - A Randomized Clinical Trial","CoBRa","Inclusion Criteria:\n\n* Have a diagnosis of TS or to experience bothersome tics;\n* Be aged 14 to 21 years inclusive at the start of therapy.\n\nExclusion Criteria:\n\n* Present a sensorimotor impairment;\n* Have a diagnosis of intellectual disability (intelligence quotient below 75);\n* Alcohol or drug abuse;\n* A neurological issue (e.g., hemifacial spasms, Huntington's disease);\n* Change medication one month or less before step 1 and up to step 4 (last measurement time) without informing a member of the research team;\n* Simultaneously receive another intervention for tics (e.g., psychologist, massage therapist) without informing a research team member.","14 Years","21 Years",{"count":66,"type":21},150,[24],"The goal of this clinical trial is to compare the effectiveness of CoPs therapy with or without the therapeutic component of biofeedback in treating tics in Tourette Syndrome with emerging young adults.\n\nHypotheses:\n\n1. The CoPs+Biofeedback treatment will improve the severity of tics (YGTSS) and the Clinical Global Impression, surpassing the clinical significance threshold of CoPs treatment alone.\n2. We expect that the identified variables (psychosocial, neurocognitive, biological) will predict the improvement of tics.\n\nResearchers will compare if the biofeedback treatment will improve the severity of tics.\n\n* In the pre-test, participants will undergo two interviews, each lasting 3 hours. These interviews will assess (through a battery of tests) the severity of tics as well as the psychosocial, biological, and neurocognitive aspects of functioning. A general assessment of intelligence and executive functions will also be conducted.\n* They will next attend 10 to 12 therapy sessions, with or without biofeedback. (The biofeedback component is explained in more detail in the ''Study Design'' section).\n* The post-test follow-ups consist of two evaluations: one 3 months after the end of the treatment and the other 6 months after. The evaluation will be done using the same battery of tests as during the pre-test interview.",[70,71,72],"Tourette Syndrome","Tics","Tourette Syndrome in Adolescence",[74,75,76,77,78,71,79],"CoPs","Biofeedback","cognitive-psychophysiological therapy","Tourette","Young adults","Treatment","2025-07-04",{"date":82,"type":46},"2025-07-08",{"date":84,"type":46},"2025-04-15",{"date":86,"type":21},"2029-12",{"name":52,"class":53},""]