[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universitat Internacional de Catalunya\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":701},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,53,81,112,146,175,206,234,260,292,311,336,355,388,420,449,474,501,537,561,583,607,634,656,677],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100636395","preved-mr-improving-emotion-dysregulation-through-mixed-reality-based-dialectical-behavioral-therapy-in-adolescents-and-young-adults-at-risk-of-developing-eating-disorders-100636395",false,"NCT07565129","PrevED MR. Improving Emotion Dysregulation Through Mixed Reality Based Dialectical Behavioral Therapy in Adolescents and Young Adults at Risk of Developing Eating Disorders.","PrevED MR","Inclusion Criteria:\n\n* Adolescents and young adults aged 13 to 35 years.\n* Spanish-speaking participants who are able to understand the study procedures and complete the assessment instruments.\n* Students recruited from participating schools, universities, or related recruitment settings.\n* Participants at mid-to-high risk of developing eating disorders, as assessed by the Eating Attitudes Test-26 (EAT-26) and selected subscales of the Eating Disorder Inventory-3 (EDI-3).\n* Participants who provide informed consent. For minors, informed consent from a parent or legal guardian will also be required, together with the minor's assent when applicable.\n\nExclusion Criteria:\n\n* Current or past self-reported diagnosis of an eating disorder.\n* Current severe psychiatric symptoms or diagnosis that could interfere with participation, including suicidal, manic, or psychotic symptoms.\n* Severe neurodevelopmental disorder, intellectual disability, or other cognitive impairment that could interfere with understanding or completing the study procedures.\n* Physical, motor, or sensory impairment that could interfere with the assessment procedures or the use of the mixed\u002Fvirtual reality intervention.\n* Current psychological or pharmacological treatment for a mental health disorder delivered on a weekly or biweekly basis.\n* Inability to understand Spanish.\n* Failure to provide informed consent. For minors, lack of parent or legal guardian consent will also be an exclusion criterion.",true,"ALL","13 Years","35 Years",{"count":22,"type":23},72,"ESTIMATED","INTERVENTIONAL",[26],"NA","The aim of this study is to evaluate the feasibility and preliminary effects of PrevED MR, a group-based preventive intervention for adolescents and young adults at risk of developing eating disorders. PrevED MR is based on dialectical behavior therapy skills and uses mixed reality and virtual reality activities to support emotion regulation, mindfulness, distress tolerance, and body-related acceptance.\n\nParticipants will be randomly assigned to either the PrevED MR intervention group or a waiting-list control group. The intervention will be delivered over 6 weeks, with two sessions per week, for a total of 12 sessions. Assessments will be conducted at baseline and after the intervention to examine changes in eating disorder symptoms, body image acceptance, emotion regulation strategies, rumination, usability, sense of presence, cybersickness, satisfaction, and adherence.",[29,30],"Eating Disorders","Emotion Dysregulation",[32,33,34,35,36,37,38,39],"Eating disorders","Eating disorder prevention","Emotion regulation","Dialectical behavior therapy","Mixed reality","Adolescents","Young adults","Body image","RECRUITING","2026-06-22",{"date":43,"type":44},"2026-06-25","ACTUAL",{"date":46,"type":44},"2026-04-28",{"date":48,"type":23},"2027-09",{"name":50,"class":51},"Universitat Internacional de Catalunya","OTHER",1,{"id":54,"slug":55,"hasResults":12,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":52},"100578039","wound-healing-and-patient-reported-outcomes-after-gingival-graft-harvesting-from-the-palate-100578039","NCT06806111","Wound Healing and Patient-Reported Outcomes After Gingival Graft Harvesting From the Palate","Wound Healing and Patient-Reported Outcomes After Autogenous Gingival Graft Harvesting From the Palate: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Systemically healthy individuals older than 18 years old;\n* Healthy periodontal status according to the AAP\u002FEFP definition;\n* Full-mouth plaque (FMPS) and bleeding scores (FMBS) ≤ 20%;\n* No history of soft tissue harvesting.\n\nExclusion Criteria:\n\n* Pregnancy or lactation;\n* Self-reported smoking ≥10 cigarettes\u002Fday;\n* Metabolic diseases that negatively affect soft tissue healing (i.e., diabetes mellitus);\n* Any medication that may interfere with wound healing;\n* Removable maxillary prostheses;\n* Ongoing orthodontic therapy.","18 Years",{"count":62,"type":23},66,[26],"The goal of this clinical trial is to evaluate whether two different techniques for treating palatal wounds-sutures and cyanoacrylate bioadhesive-can influence postoperative morbidity, clinical healing, and soft tissue dimensional changes in patients undergoing epithelialized gingival graft harvesting from the palate. The main questions it aims to answer are:\n\nDoes the use of cyanoacrylate bioadhesive reduce postoperative morbidity compared to sutures? Does the choice of wound treatment technique affect clinical healing and three-dimensional changes in soft tissues? Researchers will compare the sutures (control group) to the cyanoacrylate bioadhesive (test group) to determine if the bioadhesive leads to improved postoperative outcomes.\n\nParticipants will:\n\nUndergo epithelialized gingival graft harvesting from the palate. Receive either sutures or cyanoacrylate bioadhesive for wound closure. Be monitored for postoperative morbidity, clinical healing, and soft tissue dimensional changes.",[66],"Palatal Wound",[68,69,70,71,72],"gingival graft harvesting","wound healing agent","postoperative pain","palatal healing","palatal volumetric changes","2026-04-05",{"date":75,"type":44},"2026-04-09",{"date":77,"type":44},"2025-02-03",{"date":79,"type":23},"2026-09",{"name":50,"class":51},{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":17,"sex":87,"minAge":60,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":100,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100629706","maternal-musculoskeletal-factors-of-the-hip-lumbopelvic-abdominal-and-pelvic-floor-regions-and-their-association-with-mode-of-delivery-and-postpartum-pelvic-floor-dysfunction-100629706","NCT07478159","Maternal Musculoskeletal Factors of the Hip, Lumbopelvic, Abdominal and Pelvic Floor Regions and Their Association With Mode of Delivery and Postpartum Pelvic Floor Dysfunction","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older\n* Singleton pregnancy\n* Gestational age of 36 weeks at the time of the baseline assessment\n* Receiving prenatal care in primary healthcare centers of Zaragoza (Spain)\n* Ability to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Multiple pregnancy\n* High-risk pregnancy conditions that may affect labor progression or maternal musculoskeletal assessment (e.g., severe obstetric complications requiring planned cesarean section)\n* Previous pelvic floor surgery\n* Neurological or musculoskeletal disorders affecting the lumbopelvic or pelvic floor region\n* Inability to complete the assessment protocol or questionnaires","FEMALE","45 Years",{"count":90,"type":23},376,"OBSERVATIONAL","This prospective observational cohort study aims to investigate the association between maternal musculoskeletal factors of the hip, lumbopelvic, abdominal, and pelvic floor regions and childbirth outcomes, as well as their consequences on pelvic floor function during the postpartum period. A total of 376 pregnant women will be recruited at 36 weeks of gestation and followed until 12 weeks postpartum. Musculoskeletal assessments will include hip range of motion, lumbopelvic mobility, abdominal muscle function, and pelvic floor strength and morphology. Obstetric outcomes such as mode of delivery and perineal trauma will be recorded after childbirth. The study will analyze whether maternal musculoskeletal function during late pregnancy is associated with delivery mode and pelvic floor dysfunction in the postpartum period.",[94,95,96,97,98,99],"Pelvic Floor Disorders","Urinary Incontinence","Perineal Trauma","Pelvic Floor Dysfunction","Pregnancy","Puerperium",[94,101,102,95],"Obstetric Labor","Complications Perineal Trauma","NOT_YET_RECRUITING","2026-03-12",{"date":106,"type":44},"2026-03-17",{"date":108,"type":23},"2026-05-01",{"date":110,"type":23},"2028-01-01",{"name":50,"class":51},{"id":113,"slug":114,"hasResults":12,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":24,"phases":121,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":52},"100628634","effectiveness-of-dental-bleaching-using-different-designs-of-3d-printed-and-conventional-customized-nightguards-100628634","NCT07464197","Effectiveness of Dental Bleaching Using Different Designs of 3D-Printed and Conventional Customized Nightguards","Evaluation of the Effectiveness in Dental Bleaching by Different Designs of 3D-Printed Digital Customized Nightguards","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Good general and oral health\n* No current medical treatment (self-reported)\n* No need for surgical, endodontic, periodontal, or restorative dental treatment\n* At least six upper and six lower anterior teeth free of caries and restorations\n* Maxillary central incisors with baseline shade A2 or darker\n* Willingness to follow the study protocol and use the study-provided oral hygiene products\u002Finstructions\n\nExclusion Criteria:\n\n* Previous tooth bleaching treatment\n* Orthodontic appliances or prostheses that interfere with treatment\n* Severe intrinsic discoloration (e.g., tetracycline staining, fluorosis, or endodontically treated teeth with discoloration)\n* Pregnancy or lactation\n* Bruxism\n* Gingival recession, dentin exposure, visible enamel cracks, or other conditions associated with increased sensitivity\n* Use of anti-inflammatory or analgesic medication during the study period (according to protocol)",{"count":120,"type":23},40,[26],"This randomized, double-blind, split-mouth clinical trial evaluates the effectiveness of at-home dental bleaching using customized nightguards fabricated by digital (3D-printed CAD-CAM) and conventional methods, with and without reservoirs. Adult participants with good general and oral health and a baseline tooth shade of A2 or darker undergo bleaching with 10% carbamide peroxide. Outcomes include tooth color change (subjective and spectrophotometric measures), tooth sensitivity, gingival irritation, patient comfort, and patient satisfaction over time.",[124,125],"Tooth Discoloration","Tooth Staining",[127,128,129,130,131,132,133,134,135,136,137],"dental bleaching","custom tray","3D-printed tray","CAD-CAM","Carbamide peroxide","Nightguard vital bleaching","Tooth sensitivity","Gingival irritation","Spectrophotometer","Split-mouth trial","tooth whitening","2026-03-11",{"date":140,"type":44},"2026-03-16",{"date":142,"type":44},"2022-05-01",{"date":144,"type":23},"2026-07",{"name":50,"class":51},{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":24,"phases":155,"briefSummary":156,"conditions":157,"keywords":160,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":169,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":52},"100628771","clinical-performance-of-printed-hybrid-resin-in-indirect-restorations-100628771","NCT07465978","Clinical Performance of Printed Hybrid Resin in Indirect Restorations","Clinical Behavior of 3D-Printed VarseoSmile TriniQ Resin Versus CAD\u002FCAM Cerasmart in Indirect Restorations for Endodontically Treated Teeth: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* Signed informed consent\n* Need to restore an endodontically treated molar with an indirect adhesive overlay\n* Physically and psychologically able to tolerate conventional restorative procedures\n* No high caries risk\n* No active periodontal disease\n* Natural antagonist tooth present\n* Need for full cuspal coverage restoration (overlay)\n* Remaining wall thickness \\\u003C3 mm in the endodontically treated tooth\n* Occlusal thickness of the restoration ≥1 mm\n* Willing and able to attend follow-up visits\n\nExclusion Criteria:\n\n* Poor oral hygiene\n* Uncontrolled parafunctional habits (e.g., bruxism)\n* High caries risk\n* Active periodontal disease\n* Active pulpal disease\n* Absence of natural antagonist tooth\n* Need for partial cuspal coverage restoration (inlay or onlay)\n* Insufficient interarch space for restoration\n* Teeth planned as abutments for removable or fixed prostheses\n* Known allergy to any materials used in the study",{"count":154,"type":23},60,[26],"This randomized clinical trial aims to evaluate the clinical performance of a 3D-printed hybrid resin (VarseoSmile TriniQ) used for indirect restorations in endodontically treated teeth, compared with a CAD\u002FCAM composite block (Cerasmart). In addition, two different luting protocols will be compared: a preheated microhybrid composite (Enamel Plus HRi) and a resin cement (RelyX Universal).\n\nSixty patients requiring restoration of an endodontically treated molar with an indirect adhesive overlay will be recruited at the University Dental Clinic of the Universitat Internacional de Catalunya (Barcelona, Spain). Participants will be randomly assigned to receive restorations fabricated either using the printed hybrid resin or the CAD\u002FCAM composite material. Each material group will be further divided according to the cementation technique used.\n\nAll restorations will be fabricated following a digital workflow that includes intraoral scanning, CAD design, and either additive manufacturing (3D printing) or subtractive milling. Adhesive luting procedures will be performed according to standardized clinical protocols.\n\nClinical evaluations will be performed at baseline, 3 months, 6 months, and 12 months, and annually thereafter. The clinical performance of the restorations will be assessed using modified United States Public Health Service (USPHS) criteria, including parameters such as marginal adaptation, contact points, color stability, wear, fracture occurrence, secondary caries, and patient comfort.\n\nThe results of this study will provide clinical evidence regarding the behavior of 3D-printed hybrid resin restorations and their potential use as an alternative to conventional CAD\u002FCAM composite materials for indirect restorations in endodontically treated teeth.",[158,159],"Endodontically Treated Teeth","Indirect Restoration",[161,162,163,164,165,166,167,168],"Indirect restoration","CAD-CAM dentistry","3D printing dentistry","Hybrid resin restoration","Overlay restoration","Digital dentistry","VarseoSmile TriniQ","cerasmart",{"date":140,"type":44},{"date":171,"type":44},"2024-12-13",{"date":173,"type":23},"2027-06-01",{"name":50,"class":51},{"id":176,"slug":177,"hasResults":12,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":24,"phases":184,"briefSummary":185,"conditions":186,"keywords":189,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":52},"100627443","intraoral-vs-extraoral-cementation-of-zirconia-bridges-on-ti-bases-microstrain-evaluation-100627443","NCT07448701","Intraoral vs Extraoral Cementation of Zirconia Bridges on Ti-Bases: Microstrain Evaluation","Influence of Cementation Technique on Microstrain in Three-Unit Bridges on Ti-Bases Evaluated by Strain Gauges","Inclusion Criteria:\n\n* Adults (≥18 years old) in good general health.\n* Presence of an edentulous space requiring rehabilitation with a three-unit implant-supported fixed bridge.\n* Presence of two already osseointegrated Essential Cone implants (Klockner) indicated for a three-unit implant-supported restoration in the edentulous area.\n* Ability and willingness to participate and attend study visits and follow-up.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* ASA III or ASA IV.\n* Current or previous treatment with bisphosphonates.\n* Smoking \\>10 cigarettes\u002Fday.\n* Extraction in the study area \\\u003C3 months before implant placement with incomplete healing.\n* Guided bone regeneration in the study area with \\\u003C6 months of healing time.\n* Signs of active periodontal disease (e.g., poor plaque control and\u002For bleeding on probing above acceptable levels).",{"count":183,"type":23},30,[26],"This prospective clinical study compares two cementation techniques for implant-supported zirconia fixed partial dentures on titanium bases (Ti-bases): extraoral cementation performed on the working model and intraoral cementation performed chairside. Thirty clinical cases with two osseointegrated implants requiring a multi-unit zirconia restoration will be recruited at the UIC Dental Clinic. For each case, two restorations with identical design will be produced: one will be cemented extraorally (control) and an identical replica will be cemented intraorally (test). Micro-deformation will be assessed as peri-implant microstrain (µε) using a standardized strain-gauge setup and the same recording protocol for both techniques. The primary analysis compares microstrain between intraoral and extraoral cementation within each case; implant\u002Fprosthetic events will be recorded descriptively.",[187,188],"Biomechanical Phenomena","Partial Edentulism",[190,191,192,193,194,195,196,197],"titanium base","ti-base","zirconia bridge","intraoral cementation","passive fit","screw-retained restoration","strain gauge","CAD\u002FCAM zirconia","2026-02-28",{"date":200,"type":44},"2026-03-04",{"date":202,"type":23},"2026-03",{"date":204,"type":23},"2027-06",{"name":50,"class":51},{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":214,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":216,"conditions":217,"keywords":219,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":231,"leadSponsor":232,"locationsCount":233},"100626810","a-study-on-remote-health-support-for-patients-with-heart-failure-100626810","NCT07440472","A Study on Remote Health Support for Patients With Heart Failure.","Feasibility of Implementing a Remote Monitoring Palliative Care Model for Patients With Heart Failure.","RAPHAEL","Inclusion Criteria:\n\nPatients\n\n1. Adult patients (≥18 years) with the main diagnosis of HF according to current guidelines (20), living at home; recruitment will be stratified by sex and limited to 60-70% for either sex.\n2. Screen positive for one of the three clinical \"sensitizing\" questions, intended to identify potential palliative care (PC) needs:\n\n   'Would I be surprised if this patient were to die within one year?'\n   * A \"No\" response indicates possible palliative care needs. 'Has this patient experienced 'escalating care events' at least twice in the past year, including i) unscheduled hospitalizations for HF, ii) emergency department visits for HF, iii) visits to out-of-hours primary care services for HF, and\u002For iv) other similar escalating care events?'\n   * A \"Yes\" response indicates possible PC needs. 'Is this patient experiencing persistent or worsening multidimensional symptoms (e.g., physical, psychological, social, or spiritual concerns) despite optimal HF treatment, such that a palliative assessment is indicated (upon discretion of the treating physician or nurse)?'\n   * A \"Yes\" response indicates possible PC needs.\n3. patient's or informal caregiver's ability to use technology (e.g., having internet access, owning a smartphone or tablet, or having someone available who can assist them).\n4. capacity to provide informed consent.\n\nPrimary Caregiver:\n\n1. Informal caregiver who is present with the patient during the implementation of the intervention\n2. ≥18 years\n3. capacity to provide consent.\n\nHealthcare professionals: Two professionals identified by the consortium in each site, willing to be trained in the intervention to perform the feasibility study.\n\nExclusion Criteria:\n\n1. Acute events leading to multiple outpatient visits not related to the HF diagnosis.\n2. severe cognitive impairment or language disorders as determined by the attending healthcare professional based on clinical judgment and medical record review.\n3. simultaneous participation in another study.\n4. inability to read and write in the language in which the study is conducted.\n\nPrimary caregivers:\n\n1. Cognitive impairment or language disorders determined by the attending healthcare professional.\n2. inability to read and write in the language in which the study is conducted.\n\nHealth care professionals: a) Inability to read and write fluently in the language(s) required for the study site and for using the digital questionnaire.",{"count":215,"type":23},90,"This multicenter prospective observational feasibility study evaluates the implementation of the RAPHAEL model, a remote monitoring palliative care approach for patients with heart failure. The study aims to assess the feasibility, acceptability, usability, and implementation outcomes of integrating structured remote symptom monitoring and palliative care needs assessment into routine outpatient heart failure care.\n\nAdult patients with heart failure and worsening symptoms and\u002For potential palliative care needs will complete a structured digital questionnaire during a 4-week follow-up period. Healthcare professionals will review reported needs and conduct follow-up contact according to usual clinical practice. No experimental drugs or devices are administered, and clinical management remains at the discretion of the treating team.\n\nPrimary outcomes focus on feasibility and implementation metrics, including participation rates, acceptability, usability, perceived burden, resource requirements, fidelity to the intervention model, training adoption, applicability, adaptation, and demand.",[218],"Heart Failure",[220,221,222,223,224,225,226],"Palliative Care","Remote Monitoring","Feasibility Study","Symptom Assessment","Outpatient Care","Mix Methods","Multinational european study","2026-02-25",{"date":229,"type":44},"2026-02-27",{"date":202,"type":23},{"date":144,"type":23},{"name":50,"class":51},9,{"id":235,"slug":236,"hasResults":12,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":242,"conditions":243,"keywords":246,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":4},"100624123","knowledge-of-periodontitis-and-its-relation-to-periodontal-health-100624123","NCT07405541","Knowledge of Periodontitis and Its Relation to Periodontal Health","Knowledge of Periodontitis and Its Impact on Periodontal Health: A Comparative Observational Study in Final-Year Dentistry and Psychology Students","Inclusion Criteria:\n\n* Students enrolled in the Dentistry or Psychology degree programs at UIC.\n* Age 18 years or older.\n* Voluntary agreement to participate through signed informed consent.\n\nExclusion Criteria:\n\n* Periodontal treatment within the past 6 months.\n* Presence of uncontrolled systemic diseases that may affect periodontal status (e.g., uncontrolled diabetes, immunodeficiencies).\n* Pregnancy or breastfeeding, if deemed relevant by the Ethics Committee due to potential hormonal alterations affecting periodontal health.\n* Withdrawal or refusal of consent at any stage of the study.",{"count":154,"type":23},"This study aims to evaluate the level of knowledge regarding periodontal disease and its association with periodontal health status among health sciences students. An observational, cross-sectional, analytical, and comparative design will be conducted involving two cohorts: final-year Dentistry students and Psychology students from the Universitat Internacional de Catalunya (UIC).\n\nA total of approximately 60 participants (30 per group) will be recruited using stratified random sampling. Eligible participants must be at least 18 years old and provide written informed consent. Students who have received periodontal treatment within the previous six months, present uncontrolled systemic diseases, or are pregnant or breastfeeding will be excluded.\n\nData collection will take place during a single clinical visit between January and April 2026 and will consist of two phases. First, participants will complete a validated Knowledge, Attitudes, and Practices (KAP) questionnaire assessing understanding of periodontitis, attitudes toward oral health, and daily oral hygiene behaviors. Knowledge scores will be categorized into low, medium, and high levels. Second, a comprehensive periodontal examination will be performed by a certified periodontist under standardized conditions, including plaque index, bleeding on probing, probing depth, gingival margin position, clinical attachment loss, and radiographic assessment. Periodontal status will be classified according to the 2018 EFP\u002FAAP classification system using staging and grading criteria.\n\nThe primary outcome is the presence of periodontal disease (gingivitis or periodontitis). The main independent variable is the level of knowledge about periodontitis. Covariates include age, sex, oral hygiene habits, smoking status, perceived stress, and self-reported systemic conditions.\n\nStatistical analysis will be conducted using SPSS, Stata, or R software. Descriptive statistics will summarize participant characteristics. Bivariate analyses will assess associations between knowledge level and periodontal disease using chi-square tests and appropriate parametric or non-parametric comparisons. Multivariate binary logistic regression will be applied to evaluate whether lower knowledge levels are independently associated with a higher prevalence of periodontal disease, adjusting for relevant covariates. Statistical significance will be set at p \\\u003C 0.05.\n\nThe study will be conducted following ethical approval from the UIC Research Ethics Committee. Participation will be voluntary, confidentiality will be ensured through anonymized data handling, and participants diagnosed with periodontal disease will be referred for appropriate periodontal care.",[244,245],"Presence of Periodontal Disease","Knowledge of Periodontal Disease",[247,248,249,250,251],"knowledge","periodontitis","periodontal disease","periodontal diagnosis","dental students","2026-02-16",{"date":254,"type":44},"2026-02-18",{"date":256,"type":23},"2026-03-01",{"date":258,"type":23},"2026-07-01",{"name":50,"class":51},{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":12,"sex":18,"minAge":268,"maxAge":4,"enrollmentInfo":269,"targetDuration":4,"studyType":24,"phases":271,"briefSummary":272,"conditions":273,"keywords":278,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":4},"100624888","immediate-implants-in-front-teeth-with-bone-loss-regeneration-and-temporary-crown-in-a-randomized-clinical-study-100624888","NCT07415486","Immediate Implants in Front Teeth With Bone Loss: Regeneration and Temporary Crown in a Randomized Clinical Study","Immediate Implant Placement in Buccal Dehiscence Aesthetic Sites With Simultaneous Regeneration and Immediate Provisionalization: a Controlled Randomized Clinical.","GBR \u002F RCT","Inclusion Criteria:\n\n* • Adult patients with ⩾ 25 years of age.\n\n  * Ability to understand all the study procedures and to comply with them along the entire study period. Ability and willingness to give written informed consent.\n  * Periodontal health in an intact or reduced periodontium (2017 World Workshop in Periodontal and Peri-implant Diseases and Conditions) (G. Caton et al., 2018).\n  * Good level of oral hygiene (Plaque Index \\\u003C 20%) (Löe, 1967).\n  * Failing tooth in the anterior area of the maxillary arch (incisors, canines and premolars).\n  * Bone availability for a prosthetically driven single-unit immediate implant.\n  * A peri-implant BBD with a minimum vertical dimension height (VDH) of 3mm, detected by means of a CT imaging.\n  * Presence of adjacent teeth.\n  * Presence of antagonist teeth.\n  * Keratinized mucosa of at least 2mm on the buccal aspect of the tooth to be extracted.\n\nExclusion Criteria:\n\n* Smokers ⩾ 10 cigarettes per day.\n\n  * Pregnant women or lactating females.\n  * Acute periapical infection.\n  * Presence of buccal\u002Fpalatal and\u002For interproximal gingival recession in the target tooth.\n  * Any systemic disease or medication that contraindicates implant treatment or could influence the outcome of the therapy (i.e., non-controlled diabetes mellitus, osteoporosis, radiotherapy, bisphosphonate medication, ...).\n  * Long-term non-steroidal anti-inflammatory drug therapy (⩾ 3 months).\n  * Lack of primary manual stability of the implant during installation.","25 Years",{"count":270,"type":23},24,[26],"This clinical trial investigates the biological and clinical outcomes of immediate implant placement in aesthetic areas presenting with buccal bone dehiscence. Traditionally, these defects are treated with a bone graft and covered using a collagen membrane; however, there is ongoing debate about whether the membrane is necessary for optimal regeneration. This study proposes the use of a connective tissue graft instead of a collagen membrane, aiming to improve soft tissue volume and aesthetics without compromising bone healing.\n\nThe objective of the study is to evaluate whether the use of an autogenous connective tissue graft in combination with a deproteinized bovine bone mineral with collagen (DBBM-C) achieves results that are not inferior to the conventional protocol that uses DBBM-C and a collagen membrane. The main outcome variable is the vertical buccal bone gain measured after twelve months of healing.\n\nThe study design is a randomized controlled clinical trial including twenty-four patients divided equally into two groups. Each participant will attend eight follow-up visits over twelve months. After atraumatic tooth extraction, immediate implants (BLC, Straumann) will be placed using a prosthetically guided protocol. Buccal dehiscence will be measured intraoperatively, and a partial-thickness tunnel flap will be prepared to allow soft tissue adaptation and graft placement.\n\nIn the control group, the defect will be filled with DBBM-C and covered with a collagen membrane stabilized with horizontal mattress sutures. In the test group, the defect will receive DBBM-C covered by a connective tissue graft harvested from the palate and fixed in a similar manner. When primary stability is equal to or greater than 35 N\u002Fcm, an immediate screw-retained provisional crown will be delivered; if stability is lower, a customized healing abutment or Maryland-type provisional will be used instead.\n\nAfter three months, digital impressions will be taken to fabricate the definitive zirconia restoration. All restorative steps will be performed by experienced clinicians using a standardized digital workflow. Patients will follow routine postoperative care instructions, including soft diet and restricted brushing in the surgical area for one week.\n\nThe main benefits of this study include advancing the understanding of regeneration strategies for buccal bone dehiscence and improving clinical decision-making in immediate implant protocols. Participants are also expected to benefit from implant-supported rehabilitation, functional restoration, and aesthetic improvement. The potential risks are minimal and limited to typical surgical complications such as discomfort, swelling, or minor infection, which will be managed following established clinical protocols.\n\nIf a patient declines participation, conventional implant treatment will be offered, or alternative prosthetic options such as fixed or removable restorations will be provided. Any intra- or postoperative complications during the study will be treated promptly and documented according to institutional standards.\n\nThe biomaterials used include BLC Straumann implants, Bio-Oss Collagen (DBBM-C), Bio-Gide collagen membranes, and appropriate suture materials. Procedures will employ standard periodontal and tunneling instruments, as well as a digital intraoral scanner for accurate prosthetic fabrication.\n\nStatistical analysis will involve descriptive and inferential methods. The Kolmogorov-Smirnov test will assess normality, and mixed ANOVA models will evaluate differences between groups and across time points. Covariate adjustment will be performed using ANCOVA when necessary, and intra- and inter-examiner reliability will be tested with the intraclass correlation coefficient. The level of statistical significance will be set at 0.05.\n\nThe expected outcome is that the use of an autogenous connective tissue graft will demonstrate bone regeneration results equivalent to those obtained with a collagen membrane, while potentially improving soft tissue thickness and aesthetic integration. This finding would support the clinical use of soft tissue grafts as an alternative to collagen membranes in immediate implant placement within aesthetic regions showing buccal dehiscence.\n\nAll study procedures follow the principles of the Declaration of Helsinki and ethical standards for human clinical research. Participants will receive detailed information about the study protocol and will sign informed consent before inclusion.\n\nIn summary, this study aims to determine whether a connective tissue graft can safely replace a collagen membrane in the management of buccal dehiscence during immediate implant placement, offering comparable regenerative outcomes with possible superior soft tissue aesthetics.",[274,275,276,277],"Immediate Dental Implant Placement","Connective Tissue Graft","Connective Tissue Graft Harvesting","Soft Tissue Management in Subcrestal Dental Implants",[279,280,281,282,283],"Connective tissue graft","volumen changes in vestibular plate","immediate implant placement","emergence profile","immediate aesthetic crown","2026-02-12",{"date":286,"type":44},"2026-02-17",{"date":288,"type":23},"2026-04-01",{"date":290,"type":23},"2029-07-01",{"name":50,"class":51},{"id":293,"slug":294,"hasResults":12,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":299,"targetDuration":4,"studyType":24,"phases":301,"briefSummary":302,"conditions":303,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":310,"locationsCount":4},"100625027","clinical-and-patient-outcomes-of-4-mm-ultra-short-vs-8-mm-implants-with-bone-augmentation-in-the-back-upper-jaw-100625027","NCT07417293","Clinical and Patient Outcomes of 4 mm Ultra-Short vs. 8 mm Implants With Bone Augmentation in the Back Upper Jaw","Clinical- and Patient-related Outcomes of 4 mm Ultra-short Implants Compared to 8 Mm-long Implants With Bone Augmentation for the Rehabilitation of Posterior Atrophic Maxilla: a Randomized Controlled Clinical Trial.","inclusion criteria:\n\n* Inform consent signed.\n* Adult patients (≥18 years old).\n* No pregnant women or without the desire to stay.\n* Periodontal and peri-implant health in a pristine or reduced periodontium.\n* Full mouth plaque score \\\u003C 20% (O'Leary, 1972)\n* Maxillary multiple posterior maxillary healed sites at least 4 months after extraction (with antagonist teeth with a good prognosis (Lindhe et al. 2008)) presenting ≥ 6.5 mm of bone width and 5-6 mm in height from the bone crest to the floor of the sinus.\n* Need for a multiple splinted implant supported restoration with distal adjacent teeth or distal free-end in the posterior maxilla\n\nexclusion criteria\n\n* Patients with uncontrolled systemic diseases.\n* Smoker patients (≥10 cig\u002Fday).\n* Patients taking medications that affect bone metabolism or immunologic disorders.\n* Patients allergic to penicillin.\n* Patients presenting acute or chronic maxillary sinus lesions.\n* Advanced vertical crestal bone atrophy in the posterior maxilla (Type V and IV, Cawood-Howell Classification)\n* Vertical space of \\\u003C 6 mm for a screw-retained implant restoration.\n* Patients referring allergy to titanium or to any component of the implant\u002Frestoration.\n* No previous attempts of implant installation in the same surgical site.\n* Pregnant or lactating women.\n* Patients willing to start or in course of an orthodontic therapy.",{"count":300,"type":23},35,[26],"This study aims to compare 2 different groups of patients with both a healed site in the upper posterior sector after extractions, one treated with ultra-short implants, and another with long implants with bone regeneration. The objective is to evaluate if short-implants are superior in terms of better clinical outcomes, survival rates and safety, reduced surgical time, postoperative discomfort, and complication risk compared to conventional implants and bone regeneration.",[304],"Posterior Atrophic Maxilla","2026-02-10",{"date":254,"type":44},{"date":308,"type":23},"2026-02-20",{"date":290,"type":23},{"name":50,"class":51},{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":24,"phases":320,"briefSummary":321,"conditions":322,"keywords":324,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":335,"locationsCount":52},"100621957","factors-influencing-postoperative-pain-after-gingival-graft-harvesting-100621957","NCT07377370","Factors Influencing Postoperative Pain After Gingival Graft Harvesting","Patient-Related Factors Influencing Postoperative Pain After Gingival Graft Harvesting From the Palate: A Prospective Study","Inclusion Criteria:\n\n* Patients requiring mucogingival surgery for gingival augmentation or root coverage purposes\n* Systemically healthy individuals aged 18 years or older\n* Healthy periodontal status according to the AAP\u002FEFP definition\n* Full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) ≤ 20%\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Self-reported smoking ≥10 cigarettes\u002Fday\n* Presence of metabolic or systemic diseases that negatively affect soft tissue healing\n* Use of medications that may interfere with wound healing\n* Chronic pain disorders (e.g., fibromyalgia)\n* Psychiatric diagnoses\n* Regular use of analgesics, antidepressants, anxiolytics, or opioids\n* Allergy to the study medication (Ibuprofen)\n* History of grafting within the past 6 months\n* Ongoing orthodontic therapy",{"count":319,"type":23},93,[26],"This prospective cohort study aims to evaluate patient-related, psychological, and clinical factors influencing postoperative pain following gingival graft harvesting from the palate. Consecutive adult patients requiring mucogingival surgery for root coverage or soft tissue augmentation around teeth or dental implants will be recruited at the Clínica Universitària d'Odontologia of Universitat Internacional de Catalunya (Barcelona, Spain).\n\nAll participants will undergo standardized pre-surgical periodontal care and oral hygiene instruction prior to surgery. Gingival grafts will be harvested from the palate under local anesthesia using a standardized surgical technique. Postoperative management will include analgesic medication, antiseptic rinses, and standardized postoperative instructions.\n\nPatient-reported outcomes will be collected using validated questionnaires to assess anticipated pain, postoperative pain, stress, dental anxiety, psychological profile, personality traits, pain catastrophizing, coping strategies, oral health-related quality of life, and analgesic consumption. Postoperative pain and discomfort during eating will be recorded daily for two weeks. Clinical variables, including palatal thickness, graft dimensions, operative time, operator experience, and donor-site wound healing, will also be assessed.\n\nThe primary outcome is postoperative pain intensity following palatal graft harvesting. Secondary outcomes include operative time, donor-site discomfort, oral health-related quality of life, analgesic consumption, psychological and behavioral factors, and donor-site healing. The results of this study aim to improve understanding of factors associated with postoperative pain and to support individualized patient management in mucogingival surgery.",[323],"Postoperative Pain",[70,325,326,327,328],"gingival graft","patient-related factors","palatal wound healing","psychological profile","2026-02-03",{"date":331,"type":44},"2026-02-04",{"date":333,"type":44},"2026-02-02",{"date":48,"type":23},{"name":50,"class":51},{"id":337,"slug":338,"hasResults":12,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":4,"eligibilityCriteria":342,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":343,"targetDuration":4,"studyType":24,"phases":345,"briefSummary":346,"conditions":347,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":354,"locationsCount":4},"100623222","effectiveness-of-interproximal-cleaning-devices-for-biofilm-removal-around-posterior-single-implants-with-peri-implant-mucositis-100623222","NCT07393828","Effectiveness of Interproximal Cleaning Devices for Biofilm Removal Around Posterior Single Implants With Peri-Implant Mucositis","Efficacy of Biofilm Removal of Different Interproximal Oral Hygiene Devices Around Posterior Single Implants in Peri-Implant Mucositis: A Randomized Clinical Trial","Inclusion Criteria:\n\nAdults aged ≥18 years. Presence of at least one posterior single dental implant in function for ≥12 months.\n\nDiagnosis of peri-implant mucositis, defined as bleeding on probing with probing depths ≤5 mm and no radiographic bone loss beyond initial remodeling.\n\nGood general health (ASA I-II). Ability and willingness to comply with study procedures and follow-up visits. Provision of written informed consent.\n\nExclusion Criteria:\n\nDiagnosis of peri-implantitis (radiographic bone loss beyond initial remodeling).\n\nUncontrolled systemic diseases affecting periodontal or peri-implant health (e.g., uncontrolled diabetes mellitus).\n\nUse of systemic antibiotics or anti-inflammatory drugs within the previous 3 months.\n\nCurrent pregnancy or lactation. Current smoker of \\>10 cigarettes\u002Fday. History of periodontal therapy or professional implant maintenance within the previous 3 months.\n\nUse of medications known to affect bone metabolism (e.g., bisphosphonates). Inability to perform adequate oral hygiene or to attend scheduled study visits.",{"count":344,"type":23},75,[26],"This randomized clinical trial aims to evaluate and compare the efficacy of different interproximal oral hygiene devices for biofilm removal around posterior single dental implants in patients diagnosed with peri-implant mucositis.\n\nPeri-implant mucositis is a reversible inflammatory condition of the peri-implant soft tissues caused primarily by bacterial biofilm accumulation. Effective plaque control is essential for the prevention of disease progression to peri-implantitis. However, there is limited clinical evidence regarding the comparative effectiveness of different interproximal oral hygiene devices in implant-supported sites.\n\nA total of approximately 75 patients with posterior single implants and peri-implant mucositis will be recruited. Participants will be randomly allocated to one of the study groups, each using a specific interproximal oral hygiene device as part of their daily oral hygiene regimen. All participants will receive standardized oral hygiene instructions at baseline.\n\nClinical parameters related to peri-implant inflammation and plaque accumulation will be assessed at baseline and at follow-up visits at 1, 3, and 6 months. The primary outcome is the reduction of peri-implant biofilm accumulation. Secondary outcomes include changes in clinical inflammatory parameters around the implants.\n\nThe results of this study are expected to provide clinically relevant evidence to support evidence-based recommendations for interproximal oral hygiene in patients with dental implants affected by peri-implant mucositis.",[348],"Peri-implant Mucositis",{"date":350,"type":44},"2026-02-06",{"date":352,"type":23},"2026-02",{"date":204,"type":23},{"name":50,"class":51},{"id":356,"slug":357,"hasResults":12,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":4,"eligibilityCriteria":361,"healthyVolunteers":12,"sex":18,"minAge":362,"maxAge":363,"enrollmentInfo":364,"targetDuration":4,"studyType":24,"phases":365,"briefSummary":366,"conditions":367,"keywords":373,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":52},"100618255","graphene-reinforced-cadcam-restorations-for-mih-affected-molars-in-adolescents-a-prospective-clinical-study-100618255","NCT07329244","Graphene-Reinforced CAD\u002FCAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study","Clinical Evaluation of Graphene-Reinforced CAD\u002FCAM Indirect Restorations in Molars Affected by Molar-Incisor Hypomineralization (MIH) in Adolescents: A Clinical Study","Inclusion Criteria:\n\n* Adolescents aged 10-16 years.\n* Permanent molars with moderate or severe MIH (EAPD criteria).\n* Vital and restorable teeth.\n* Ability to attend follow-up visits.\n* Informed consent from guardian + assent from the minor.\n\nExclusion Criteria:\n\n* Fluorosis, amelogenesis imperfecta, or other enamel defects.\n* Severe bruxism not controlled.\n* Active extensive caries or irreversible pulpitis.\n* Systemic conditions affecting enamel or healing.\n* Hypersensitivity\u002Fallergy to materials\u002Fadhesives.\n* Use of analgesics\u002FAINEs \\\u003C24 h before baseline VAS.\n\n  * Orthodontic bands on the study molar.","10 Years","16 Years",{"count":183,"type":23},[26],"This study evaluates the clinical performance, marginal integrity, surface wear, color stability, and postoperative sensitivity of graphene-reinforced CAD\u002FCAM indirect restorations (inlays, onlays, overlays) in molars affected by moderate to severe Molar-Incisor Hypomineralization (MIH) in adolescents. A total of 30 patients aged 10-16 years will receive minimally invasive indirect restorations fabricated from a nano-reinforced graphene polymer (G-CAM®). Clinical outcomes will be assessed using FDI criteria, VAS sensitivity scores, patient satisfaction, and digital 3D scans over a 12-month follow-up. The study aims to determine clinical acceptability and safety compared with historical outcomes reported for composite and lithium-disilicate indirect restorations.",[368,369,370,371,372,159],"Tooth Demineralization","Tooth Sensitivity","Enamel Mineralization Disorders","Tooth Sensitivity After Composite Restorations","Tooth Eruption Disorder",[374,375,376,377,378,379],"molar-incisor hypomineralization","MIH","enamel defects","indirect restorations","minimally invasive dentistry","adhesive dentistry","2025-12-28",{"date":382,"type":44},"2026-01-09",{"date":384,"type":23},"2026-01-10",{"date":386,"type":23},"2027-01-11",{"name":50,"class":51},{"id":389,"slug":390,"hasResults":12,"nctId":391,"briefTitle":392,"officialTitle":393,"acronym":4,"eligibilityCriteria":394,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":395,"targetDuration":4,"studyType":24,"phases":397,"briefSummary":398,"conditions":399,"keywords":403,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":52},"100613118","debriefing-styles-and-clinical-judgment-in-nursing-students-100613118","NCT07262424","Debriefing Styles and Clinical Judgment in Nursing Students","The Influence of Instructor-centered Versus Learner-centered Debriefing on Clinical Judgment in Nursing Students: A Mixed-methods Experimental Study Protocol.","Inclusion Criteria:\n\n-Students enrolled in the Basic Simulation Labs 2 (LBS2) course as part of their program.\n\nExclusion Criteria:\n\n* Students who cannot participate in all phases of the study.\n* Students who do not provide informed consent.\n* Students who are repeating the course.",{"count":396,"type":23},110,[26],"Simulation is a cornerstone of health sciences education, with debriefing being its most critical component for fostering clinical skills. While various debriefing styles exist, there is limited evidence comparing the effectiveness of instructor-centered (ICT) versus learner-centered (LCT) approaches, specifically on the development of clinical judgment in nursing students.",[400,401,402],"Simulation Based Learning","Nursing Education","Debriefing Method",[404,405,406,407,408,401,409,410,411],"Clinical Judgment","Learner-Centered Teaching","Instructor-Centered Teaching","Mixed-Methods Study","Debriefing","Simulation","Randomized Controlled Trial","Undergraduate Health Education","2025-12-08",{"date":414,"type":44},"2025-12-09",{"date":416,"type":44},"2025-10-10",{"date":418,"type":23},"2026-05",{"name":50,"class":51},{"id":421,"slug":422,"hasResults":12,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":427,"enrollmentInfo":428,"targetDuration":4,"studyType":24,"phases":430,"briefSummary":431,"conditions":432,"keywords":435,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":448,"locationsCount":52},"100613005","effects-of-a-multimodal-telerehabilitation-program-in-patients-with-chronic-non-specific-neck-pain-100613005","NCT07260955","Effects of a Multimodal Telerehabilitation Program in Patients With Chronic Non-Specific Neck Pain.","Effects of a Multimodal Telerehabilitation Program in Patients With Chronic Non-Specific Neck Pain: Randomized Clinical Trial.","Inclusion Criteria:\n\n* Non-specific neck pain for at least the last 12 weeks.\n* Pain intensity equal to or greater than 4 on the visual analog scale (VAS).\n* Mild-moderate disability in the Neck Disability Index.\n* Not reaching phase 2 in Craniocervical flexion test.\n* Availability and skill to do video calls.\n* Understanding Spanish.\n\nExclusion Criteria:\n\n* Other type of neck pain.\n* Previous neck surgery.\n* Diagnosed metabolic diseases.\n* Red flags (infection, tumors, rheumatic arthritis, or cardiovascular disease).\n* History of cardio-respiratory disease that contraindicates high-intensity exercise.\n* Fibromyalgia\n* Pregnancy\n* Physiotherapeuthic treatment continued in the last 3 month.","65 Years",{"count":429,"type":23},54,[26],"The purpose of this study is to evaluate the clinical results in pain intensity, neck disability, range of motion, endurance deep cervical muscles, forward head position and kinesiophobia through thoracic spine mobility, deep neck muscles and thoracic strength training and pain education protocol versus a thoracic spine mobility, thoracic strength training and pain education protocol in patients with chronic non-specific neck pain.",[433,434],"Chronic Neck Pain","Non-specific Neck Pain",[436,437,438,439,440],"Neck muscles","Chronic neck pain","Telerehabilitation","Exercise therapy","Pain education","2025-11-21",{"date":443,"type":44},"2025-12-03",{"date":445,"type":23},"2025-12",{"date":447,"type":23},"2026-06",{"name":50,"class":51},{"id":450,"slug":451,"hasResults":12,"nctId":452,"briefTitle":453,"officialTitle":453,"acronym":454,"eligibilityCriteria":455,"healthyVolunteers":17,"sex":18,"minAge":362,"maxAge":363,"enrollmentInfo":456,"targetDuration":4,"studyType":24,"phases":458,"briefSummary":459,"conditions":460,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":466,"lastUpdatePostDateStruct":467,"startDateStruct":469,"completionDateStruct":471,"leadSponsor":473,"locationsCount":52},"100534291","e-emotio-project-a-gamified-preventive-school-based-paradigm-using-virtual-reality-technologies-for-improving-emotional-regulation-in-children-and-adolescents-100534291","NCT06236919","E-Emotio Project A Gamified Preventive School-based Paradigm Using Virtual Reality Technologies for Improving Emotional Regulation in Children and Adolescents.","e-Emotio","Inclusion Criteria:\n\n* School-aged participants (aged 10 to 16 years old)\n* Individuals who provide consent to participate.\n\nExclusion Criteria:\n\n* A previous diagnosis of severe psychiatric (e.g., maniac, or psychotic symptoms).\n* A previous diagnosis of severe psychiatric neurodevelopmental disorders (i.e., severe autism spectrum disorders, intellectual disabilities, etc),\n* A previous diagnosis of severe physical, motor, or sensory impairments that could interfere with the examination or the VR program.\n* Participants who cannot understand Spanish.",{"count":457,"type":23},160,[26],"Introduction and Significance: Preventive interventions have been shown to reduce the risk of developing anxiety and depression, making them a critical focus area in mental health promotion for children and adolescents. Enhancing emotion regulation (ER) skills in young people is one approach to preventing anxiety and depression, as ER involves cognitive processes of modifying thoughts and behaviors to manage emotional responses in different contexts. Executive functions (EF), such as cognitive flexibility, working memory, and inhibition, play a crucial role in ER development and regulation in children and adolescents. Recently, immersive virtual reality (IVR) has emerged as a novel tool for improving cognitive training interventions' accessibility and effectiveness. IVR allows users to experience immersive, three-dimensional environments, where they can interact with objects and events in a highly engaging and realistic way. Considering these developments, this study aims to explore the potential benefits of Enhance VR, a gamified IVR program designed to improve ER skills and reduce anxiety and depressive symptoms among children and adolescents.\n\nMethodology: The study will be a longitudinal, parallel, single-blind, randomized controlled pilot trial involving 80 Spanish - or English-speaking participants aged 10 to 16 years old. Participants will be excluded if they have severe psychiatric or neurodevelopmental disorders, physical, motor, or sensory impairments, or a risk of experiencing high cybersickness symptomatology during the VR experience. Participants will be randomly allocated into two groups: an experimental group receiving E-Emotio VR and a control group receiving a placebo-based VR relaxation experience. Both VR interventions will last five weeks, two times a week, for 30 minutes. The experimental group will engage in six games targeting cognitive flexibility, planning, reappraisal strategies, working memory, divided and sustained attention, and processing speed. The control group will be immersed in ten different nature-based VR environments and perform relaxation exercises. Baseline and post-intervention assessments will be conducted using age-adapted validated measures of depressive and anxiety symptoms, ER, executive function (working memory, cognitive flexibility, inhibition, and planning), and attention. Following the intervention, the assessment battery will be re-administered by a blinded assessor, and statistical analyses will be conducted for all the primary and secondary measures assessed before and after the intervention in both groups.\n\nConclusion: In summary, this study aims to contribute to the development of effective preventive interventions for emotion regulation and mental health symptoms in children and adolescents by promoting ER through gamified VR cognitive training. The study's findings could have significant implications for mental health research, educational and clinical practice. By exploring the potential benefits of VR cognitive training, this research has the potential to inform future studies and clinical interventions aimed at improving young people's mental health and well-being. The gamification of cognitive training interventions could be a powerful tool for increasing engagement and motivation among young people, making them more likely to participate in such interventions.",[461,462,463,464,465],"Emotional Regulation","Virtual Reality","Anxiety","Depression","Executive Function","2025-09-30",{"date":468,"type":44},"2025-10-06",{"date":470,"type":44},"2024-02-01",{"date":472,"type":23},"2026-04-25",{"name":50,"class":51},{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":479,"acronym":4,"eligibilityCriteria":480,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":481,"targetDuration":4,"studyType":24,"phases":483,"briefSummary":484,"conditions":485,"keywords":487,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":492,"lastUpdatePostDateStruct":493,"startDateStruct":495,"completionDateStruct":497,"leadSponsor":499,"locationsCount":500},"100586372","polynucleotide-and-hyaluronic-acid-based-gel-as-adjunctive-therapy-to-non--surgical-treatment-of-intraosseous-peri-implant-defect-a-randomized-clinical-trial-100586372","NCT06914518","Polynucleotide and Hyaluronic Acid-based Gel as Adjunctive Therapy to Non- Surgical Treatment of Intraosseous Peri-implant Defect. A Randomized Clinical Trial","Polynucleotide and Hyaluronic Acid-based Gel as Adjunctive Therapy to Non- Surgical Treatment of Intraosseous Peri-implant Defect. A 6-month Randomized Clinical Trial","Inclusion Criteria:\n\nSubjects with (I) ≥ 18 years of age, the presence of at least one implant diagnosed with peri-implantitis, intraosseous ≥ 3mm defects, presence of screw-retained single-unit crowns and partial dental prosthesis that allowed correct access for brushing; and, if not, prostheses that could be modified.\n\nExclusion Criteria:\n\nSubjects will be excluded from the study if they had received previous non-surgical peri-implantitis treatment during the last 6 months or surgical treatment, were pregnant or breast-feeding, had received antibiotic treatment in the previous 3 months, had systemic conditions that contraindicated treatment, smoking more than 10 cigarettes\u002Fday or presents a poor plaque control (Plaque Index \\\u003C 20%), implant mobility.",{"count":482,"type":23},32,[26],"This randomized, placebo-controlled clinical trial evaluates the efficacy of a polynucleotide and hyaluronic acid-based gel (PN-HA) as adjunctive therapy to non-surgical flapless treatment of peri-implantitis. The main goal is to assess probing pocket depth (PPD) reduction after 6 months compared to placebo.\n\nStudy Design:\n\n* Type: Interventional (Clinical Trial)\n* Allocation: Randomized (computer-generated blocks)\n* Intervention Model: Parallel assignment\n* Masking: Single-blind (examiner-blinded)\n* Primary Purpose: Treatment\n* Estimated Enrollment: 32 participants\n* Duration: 6 month follow-up",[486],"Peri-implantitis",[488,489,490,491],"peri-implantitis","non-surgical treatment","non-surgical treatment per-implantitis","hyaluronic acid","2025-09-17",{"date":494,"type":44},"2025-09-23",{"date":496,"type":23},"2025-09-20",{"date":498,"type":23},"2026-06-01",{"name":50,"class":51},2,{"id":502,"slug":503,"hasResults":12,"nctId":504,"briefTitle":505,"officialTitle":506,"acronym":507,"eligibilityCriteria":508,"healthyVolunteers":12,"sex":87,"minAge":20,"maxAge":509,"enrollmentInfo":510,"targetDuration":4,"studyType":24,"phases":511,"briefSummary":512,"conditions":513,"keywords":519,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":536,"locationsCount":4},"100606060","effectiveness-of-a-therapeutic-exercise-program-with-specific-upper-limb-exercises-to-reduce-lymphedema-and-neuropathy-in-breast-cancer-patients-a-pre-post-study-lynma-100606060","NCT07170631","Effectiveness of a Therapeutic Exercise Program With Specific Upper Limb Exercises to Reduce Lymphedema and Neuropathy in Breast Cancer Patients: A Pre-post Study (LYNMA)","Effectiveness of a General Therapeutic Exercise Program Including Specific Upper Limb Exercises to Reduce Lymphedema and Peripheral Neuropathy Secondary to Oncological Treatment in Patients With Breast Cancer: A Pre-post Intervention Study (LYNMA)","LYNMA","Inclusion Criteria:\n\n* Patients receiving treatment for breast carcinoma.reatments include surgical procedures (breast-conserving surgery or mastectomy), axillary lymph node dissection, sentinel lymph node biopsy, radiotherapy, chemotherapy, and hormone therapy.\n* Participants must provide authorization from their primary care physician and\u002For oncologist to perform therapeutic exercise.\n* Diagnosis of lymphedema associated with stage I or II breast cancer (Stage 1 or mild: circumference difference less than 4 cm \\[volume difference 10-25%\\] compared to the healthy arm; Stage 2 or moderate: circumference difference between 4 and 6 cm \\[volume difference 25-50%\\] compared to the healthy arm).\n* A score of 4 or higher on the DN4 questionnaire (neuropathic pain)\n\nExclusion Criteria:\n\n* Lack of medical authorization.\n* Pre-existing cardiac pathology prior to cancer diagnosis.\n* Exacerbation of comorbidities.\n* Travel time exceeding 45 minutes to the location where the therapeutic exercise program is conducted.","70 Years",{"count":183,"type":23},[26],"This study aims to evaluate the effectiveness of a therapeutic exercise program designed specifically for women with breast cancer. The program includes general exercises along with specific movements for the upper limb to help reduce common side effects of cancer treatment such as lymphedema (swelling of the arm) and neuropathy (nerve pain or numbness). Participants will undergo the exercise program and be assessed before and after to determine improvements in their symptoms and overall quality of life. The goal is to provide evidence that targeted physical therapy can improve recovery and well-being in breast cancer survivors.",[514,515,516,517,518],"Lymphedema Arm","Lymphedema Due to Radiation","Lymphedema, Breast Cancer","Peripheral Neuropathy Due to Chemotherapy","Peripheral Neuropathy in Breast Cancer Patient",[520,521,522,523,524,525,526,527,528],"Therapeutic exercise","Breast cancer","Lymphedema","Peripheral neuropathy","Upper limb exercises","Oncology physiotherapy","Neural mobilization","Neurodynamic techniques","Peripheral nerve ultrasound","2025-09-12",{"date":531,"type":44},"2025-09-18",{"date":533,"type":23},"2026-01",{"date":535,"type":23},"2026-10",{"name":50,"class":51},{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":4,"eligibilityCriteria":543,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":544,"enrollmentInfo":545,"targetDuration":4,"studyType":24,"phases":547,"briefSummary":548,"conditions":549,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":4},"100585728","capacitive-resistive-electric-transfer-therapy-on-muscle-recovery-100585728","NCT06906146","Capacitive Resistive Electric Transfer Therapy on Muscle Recovery","Effectivness of Capacitive Resistive Electric Transfer Therapy on Muscle Recovery in Athletes","Inclusion Criteria:\n\n* Athletes who practice a type of sport that requires the use of anaerobic muscle metabolism (cycling, athletics, triathlon, crossfit, spinning and duathlon)\n* Athletes must be federated and train a minimum of 4 days\u002Fweek\n* Active participation in regional, national or international competitions.\n\nExclusion Criteria:\n\n* Volunteers who have suffered a sports injury that makes it impossible for them to perform the test\n* Having received the CRET therapy technique.\n* Subjects who report allergies to the conductive cream.\n* Subjects undergoing pharmacological medical treatment that may interfere with the measurements.","40 Years",{"count":546,"type":23},50,[26],"This study aims to evaluate the effectiveness of Capacitive Resistive Electric Transfer (CRET) therapy combined with post-competition massage in the recovery and muscle function of professional athletes. It is designed as a randomized, double-blind, crossover clinical trial. The primary objective is to analyze the efficacy of this combined protocol in muscle recovery after performing the Wingate anaerobic power and capacity test. Secondary objectives include assessing changes in muscle fatigue, muscle function of the rectus femoris and vastus lateralis, physiological changes in blood lactate concentration and oxygen saturation, and intramuscular structural changes through ultrasound before and after the intervention.\n\nThe study will recruit professional athletes from disciplines that require anaerobic muscle metabolism, such as cycling, athletics, triathlon, CrossFit, and duathlon. Participants must be federated athletes who train at least four times per week and actively compete at regional, national, or international levels. Exclusion criteria include recent sports injuries preventing test performance, prior exposure to CRET therapy, allergies to conductive gel, language barriers, participation in other research studies, or ongoing pharmacological treatment that could interfere with measurements.\n\nParticipants will attend four study sessions, divided into two sets of two consecutive days. On the first day, they will perform the Wingate test followed by the assigned post-competition massage with either CRET therapy or a placebo intervention. On the second day, they will repeat the Wingate test. After a three-week washout period, participants will switch to the opposite group. The intervention group will receive a 60-minute CRET therapy session with both resistive and capacitive modes applied at different power intensities, combined with a standardized recovery massage. The placebo group will receive the same massage while undergoing a simulated CRET therapy, with the machine turned on but without power application to prevent participant awareness of the placebo condition.\n\nThe study will analyze various dependent variables, including Wingate test performance, blood lactate levels, subjective fatigue perception using the modified Borg scale, muscle stiffness and tone through myotonometry, muscle oxygen saturation via near-infrared spectroscopy (NIRS), cross-sectional muscle area and grayscale values from ultrasound imaging, body composition using a Tanita analyzer, maximum isometric quadriceps strength via handheld dynamometry, and muscle activity measured by surface electromyography (sEMG). Each of these variables will be assessed at specific time points before, during, and after the intervention.\n\nThe estimated sample size is approximately 50 subjects, with 25 participants per group, determined through a preliminary pilot study. Statistical analyses will be conducted using IBM SPSS Statistics 26.0. Descriptive statistics will be calculated for quantitative and qualitative variables. A linear mixed model will be applied to compare changes between and within groups over five measurement periods using a one-way mixed ANOVA. If the sphericity assumption is violated, the Greenhouse-Geisser correction will be applied. Statistically significant effects will undergo post-hoc analysis with Bonferroni correction for multiple comparisons. All originally enrolled participants will be included in the final analysis following an intention-to-treat approach, and effect sizes will be calculated using eta squared. The significance level will be set at p \\\u003C 0.05.",[550,551,552],"Muscle Oxygenation","Lactate","Anaerobic Exercise","2025-03-28",{"date":555,"type":44},"2025-04-02",{"date":557,"type":23},"2025-04-10",{"date":559,"type":23},"2025-06-10",{"name":50,"class":51},{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":4,"eligibilityCriteria":567,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":568,"targetDuration":4,"studyType":24,"phases":570,"briefSummary":571,"conditions":572,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":52},"100580947","the-adjunctive-effect-of-a-titanium-brush-in-the-non-surgical-treatment-of-peri-implantitis-100580947","NCT06843928","The Adjunctive Effect of a Titanium Brush in the Non-Surgical Treatment of Peri-Implantitis","The Adjunctive Effect of a Titanium Brush in the Non-Surgical Treatment of Peri-Implantitis: a Randomized Multi-Center Controlled Clinical Trial","Inclusion Criteria:\n\n* Adult patients with ≥18 years of age.\n* Ability to understand all the study procedures and to comply with them along the entire study period. Ability and willingness to give written informed consent.\n* An adequate level of oral hygiene (plaque index ≤ 25%) (O'Leary et al., 1972).\n* Treated periodontal disease.\n* Presence of at least one titanium implant with peri-implantitis \\[i.e., presence of bleeding and\u002For suppuration on gentle probing with probing depth of ≥6 mm, and progressive bone loss. In the absence of initial radiographs, a bone level ≥2 mm apical to the most coronal part of the intrabony portion of the implant will be used as threshold of disease (Romandini et al., 2021)\\].\n* Horizontal and vertical peri-implant bone defects.\n* Implant function time ≥ 1 year.\n* Presence of ≥2mm of keratinized peri-implant mucosa.\n* Screw-retained single and multiple restorations.\n\nExclusion Criteria:\n\n* Untreated periodontitis.\n* Smokers \\> 10 cigarettes per day.\n* Local or systemic diseases that would interfere with routine periodontal therapy (i.e., uncontrolled diabetes mellitus, cancer, HIV, chronic high-dose steroid therapy, metabolic bone disease, radiation, immunosuppressive disease, hepatic dysfunction, immunosuppressive disease, autoimmune disease).\n* Pregnant or lactating women.\n* Previous surgical and non-surgical treatment of affected implants at least 12 months prior to the beginning of the study.\n* Radiographic peri-implant bone loss \\> two-thirds.\n* Mobility of the implant.\n* Known allergy or intolerance to macrolides.\n* Use of systemic antibiotics during the last 3 months.\n* Need of endocarditis prophylaxis.",{"count":569,"type":23},36,[26],"Peri-implantitis is a plaque-associated condition occurring around dental implants, characterized by inflammation in the peri-implant mucosa and loss of supporting bone. To stop this progression, mechanical debridement of biofilm and calculus is commonly used to treat peri-implant lesions as well as the use of adjunctive measures such as titanium brushes. As observed, they improved plaque removal when compared with steel curettes alone. Therefore, it is of interest to evaluate the impact of this procedure in terms of clinical, radiographic and microbiological outcomes to assess their efficacy.",[486,573,574],"Titanium Brush","Non-surgical Submucosal Debridement","2025-02-23",{"date":577,"type":44},"2025-02-25",{"date":579,"type":44},"2024-06-12",{"date":581,"type":23},"2026-07-16",{"name":50,"class":51},{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":4,"eligibilityCriteria":589,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":590,"targetDuration":4,"studyType":24,"phases":591,"briefSummary":592,"conditions":593,"keywords":595,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":604,"leadSponsor":606,"locationsCount":4},"100574131","vestibular-incision-subperiosteal-tunnel-access-vista-technique-versus-coronally-advanced-flap-caf-combined-with-a-connective-tissue-graft-for-the-treatment-of-maxillary-gingival-recessions-100574131","NCT06755294","Vestibular Incision Subperiosteal Tunnel Access (VISTA) Technique Versus Coronally Advanced Flap (CAF) Combined With a Connective Tissue Graft for the Treatment of Maxillary Gingival Recessions","Vestibular Incision Subperiosteal Tunnel Access (VISTA) Technique Versus Coronally Advanced Flap (CAF) Combined With a Connective Tissue Graft for the Treatment of Maxillary Gingival Recessions: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy adults: men and women between 18 and 75 years of age.\n* Accepts and signs informed consent.\n* Systemically healthy patients with periodontal health or controlled periodontitis.\n* Presence of at least two maxillary Cairo Type I or II (RT1\u002F2) recessions \\> 2 mm deep on buccal aspect.\n* Plaque index ≤20%\n* No previous periodontal surgeries performed.\n* Presence of the cementoenamel junction (CEJ), a 1 mm step in the CEJ and\u002For presence of root abrasion, but with an identifiable CEJ will be accepted.\n\nExclusion Criteria:\n\n* Smoker of 10 ≥ cigarettes per day.\n* Contraindications to periodontal surgery.\n* Medications that affect the gingiva or their healing.\n* Active orthodontic treatment.\n* Pregnant women\n* Caries or restorations in the area to be treated.\n* Patients who cannot follow the post-surgical medication adequately",{"count":183,"type":23},[26],"Gingival recession (GR) is a common oral health problem that causes sensitivity, esthetic concerns and hygiene problems. Successful root coverage can be achieved by various surgical techniques. The VISTA technique may overcome some of the limitations of other techniques and present equal results to techniques that are considered the \"Gold Standard\" in this area of periodontology.\n\nThe objective of the research is to study the VISTA technique in terms of complete root coverage, % root coverage, gingival thickness gain, bleeding on probing, keratinized gingival width, PROMS, vestibular depth and esthetic results.",[594],"Gingival Recessions",[596,597,598],"VISTA TECHNIQUE","CAF","Root Coverage","2025-01-25",{"date":601,"type":44},"2025-01-28",{"date":603,"type":23},"2025-01-30",{"date":605,"type":23},"2026-06-15",{"name":50,"class":51},{"id":608,"slug":609,"hasResults":12,"nctId":610,"briefTitle":611,"officialTitle":612,"acronym":4,"eligibilityCriteria":613,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":614,"targetDuration":4,"studyType":24,"phases":615,"briefSummary":617,"conditions":618,"keywords":622,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":629,"completionDateStruct":631,"leadSponsor":633,"locationsCount":52},"100421321","phase-4-behavioral-comparison-of-three-different-graft-materials-to-increase-soft-tissue-thickness-around-dental-implants-100421321","NCT04766255","Behavioral Comparison of Three Different Graft Materials to Increase Soft Tissue Thickness Around Dental Implants.","Behavioral Comparison of Three Different Graft Materials to Increase Soft Tissue Thickness Around Dental Implants in Terms of Volume Gain and Stability Over Time: A Randomized Clinical Trial.","Inclusion Criteria:\n\nPatients referred to Department of Periodontology (CUO) in need of a single implant and need of soft tissue augmentation such as buccal defects, thin biotype, lack of keratinized tissue and aesthetic compromised situation.\n\n* The patient must be ≥18 years and able to understand the nature of the proposed surgery and must sign an informed consent.\n* The implant must be located between 2 fixed reference points (i.e. clinical crowns).\n* Anterior and premolar teeth (from premolar to premolar).\n* Enough crestal bone width to leave a minimum thickness of 2mm at the buccal bone plate when placing the implant.\n* Palate must have ≥2mm of thickness at premolar area.\n* Full mouth plaque and bleeding score \\\u003C20%.\n\nExclusion Criteria:\n\n* Pregnant or lactation.\n* Active periodontal disease.\n* Previous soft tissue augmentation in the area.\n* Need of guided bone regeneration (GBR) during or after the placement of the implant.\n* Heavy smokers (\\> 10 cigarettes per day).\n* Local or systemic conditions that would interfere with routine periodontal therapy (non-controlled diabetes mellitus, cancer, HIV, Chronic High dose steroid therapy, bone metabolic diseases, radiation, immunosuppressive disorders, liver function disorder, immunosuppressant disease, autoimmune disease).\n* Allergy to non-steroidal anti-inflammatory drugs.\n* Patients taking medications that cause gingival enlargement.",{"count":154,"type":23},[616],"PHASE4","The purpose of the study is to compare soft tissue volume changes in terms of volume gain and stability around dental implants and PROMS in cases where a sub-epithelial connective tissue graft (SCTG) from the palate, Porcine collagen matrix (CM) or Porcine Acellular dermal matrix (PADM) is used after 3 and 15 months after implant placement.",[619,620,621],"Soft Tissue Atrophy","Mucogingival Deformity on Edentulous Ridge","Edentulous Alveolar Ridge",[623,624,625],"soft tissue graft","acellular dermal graft","collagen matrix","2024-12-05",{"date":628,"type":44},"2024-12-11",{"date":630,"type":44},"2021-05-01",{"date":632,"type":23},"2026-12-30",{"name":50,"class":51},{"id":635,"slug":636,"hasResults":12,"nctId":637,"briefTitle":638,"officialTitle":638,"acronym":4,"eligibilityCriteria":639,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":640,"targetDuration":4,"studyType":24,"phases":641,"briefSummary":642,"conditions":643,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":648,"lastUpdatePostDateStruct":649,"startDateStruct":651,"completionDateStruct":653,"leadSponsor":655,"locationsCount":52},"100569522","submerged-vs-non-submerged-guided-bone-regeneration-simultaneous-to-implant-placement-100569522","NCT06695338","Submerged Vs Non-Submerged Guided Bone Regeneration Simultaneous to Implant Placement.","Inclusion Criteria:\n\n* • Men and women over 18 years old.\n\n  * Patients requiring single-unit implant restoration in any tooth site of the maxilla and mandible in between teeth.\n  * Anticipation of a peri-implant buccal osseous dehiscence by means of a CT imaging (cone-beam computed tomography, CBCT) with a maximum vertical dimension height (VDH) of 50%.\n  * Presence of adjacent teeth.\n  * Presence of antagonist teeth.\n  * Minimum primary stability of 25Ncm.\n  * Non-smokers or light smokers (\\\u003C 10 cigarettes per day).\n  * Absence of systemic diseases that could influence the outcome of the therapy (i.e., uncontrolled diabetes mellitus, osteoporosis, biphosphonate medication).\n  * Tooth extraction performed at least 4 months before implant placement.\n  * Good level of oral hygiene (Plaque Index \\\u003C 25%) (Löe, 1967)\n  * Written informed consent signed.\n  * Keratinized mucosa of at least 2mm on the buccal and lingual of the implant.\n\nExclusion Criteria:\n\n* Implant surgery requiring sinus lift procedure.\n\n  * Previous bone augmentation at the implant site.\n  * Active periodontal disease.\n  * Acute infection at the rehabilitation site.\n  * Long-term non-steroidal anti-inflammatory drug therapy (3 months).\n  * Lactating females or currently pregnancy.\n  * Severe cognitive or psychiatric disorders.\n  * Unwillingness to return for follow-up examination.",{"count":482,"type":23},[26],"Dental implants are worldwide recognized one of the best manners to replace lost or hopeless prognosis teeth. There are different variables that creates proper conditions for long-term prognosis of implant treatments.\n\nImplant position and surrounding bone around them, have been described in scientific literature to be key factors in the longevity of those treatments.\n\nIt has to be defined the \\"critical bone thickness\\" around implants. It basically means that implants has to be completely surrounded by bone, that will serve as protection. If the implants are not surrounded by bone, procedures as guided bone regeneration may be performed.\n\nThose procedures can be executed before or simultaneously during the implant placement. In the standard procedure, the simultaneous guided bone regeneration during implant placement requires to leave the implant and the regeneration healing below the gingiva, needing a second surgery for accesing to those implants.\n\nIn this randomized controlled trial the hypothesis is to discover if not submerging this regenerations may show the same results than submerged ones.\n\nFor that, the objective is to study the different variables around these regeneration to evaluate the performance of non-submerged protocol.",[644,645,646,647],"Guided Bone Regeneration","Dental Implant","Submerged Regeneration","Bone Atrophy","2024-11-16",{"date":650,"type":44},"2024-11-19",{"date":652,"type":23},"2024-12-15",{"date":654,"type":23},"2026-06-06",{"name":50,"class":51},{"id":657,"slug":658,"hasResults":12,"nctId":659,"briefTitle":660,"officialTitle":661,"acronym":4,"eligibilityCriteria":662,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":663,"enrollmentInfo":664,"targetDuration":4,"studyType":24,"phases":665,"briefSummary":666,"conditions":667,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":669,"lastUpdatePostDateStruct":670,"startDateStruct":672,"completionDateStruct":674,"leadSponsor":676,"locationsCount":4},"100567727","focal-vibration-for-enhancing-athletic-speed-and-ppower-100567727","NCT06671951","Focal Vibration for Enhancing Athletic Speed and Ppower","Effectiveness of Focal Vibration in Enhancing Lower Extremity Speed and Power in Athletes","Inclusion Criteria:\n\n* Study participants must have signed the informed consent form to assess their inclusion in the study.\n* Familiarity with the technique and practice of the weighted free squat.\n* Training at least 3 times per week.\n\nExclusion Criteria:\n\n* Volunteers who have suffered a sports injury during the last two months or are unable to perform physical activity.\n* Have previously received an intervention with focal vibration.\n* Not understanding the information provided by the therapist.\n* Participate in other research studies.\n* Be undergoing pharmacological medical treatment that may interfere with the measurements, such as treatment with anticonvulsants, antidepressants, etc.","30 Years",{"count":22,"type":23},[26],"A focal vibration device will be used to perform an activation and warm-up protocol before performing a set of 7 repetitions of squat with 60% of your 1RM.",[668],"To Assess the Effectiveness of a Focal Vibration Treatment on Squat Power and Speed in Athletes Who Perform Squats","2024-10-31",{"date":671,"type":44},"2024-11-04",{"date":673,"type":23},"2024-11-05",{"date":675,"type":23},"2024-12-06",{"name":50,"class":51},{"id":678,"slug":679,"hasResults":12,"nctId":680,"briefTitle":681,"officialTitle":682,"acronym":4,"eligibilityCriteria":683,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":684,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":686,"conditions":687,"keywords":689,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":693,"lastUpdatePostDateStruct":694,"startDateStruct":696,"completionDateStruct":698,"leadSponsor":700,"locationsCount":52},"100554884","do-penicillin-allergic-patients-presents-a-high-risk-of-sinus-lift-failure-100554884","NCT06504888","Do Penicillin-allergic Patients Presents a High Risk of Sinus Lift Failure","Influence of Penicillin-allergy on Sinus Lift Procedures: a Retrospective Study","Inclusion Criteria: men and women over 18 years of age, patients undergoing at least one sinus lift procedure with simultaneous or deferred placement of implants; and patients' containing the following data: (1) Penicillin allergy: presence or absence; (2) Prescribed antibiotic guidelines; (3) Intraoperative complications: no complications, Schneider membrane's perforation; (4) Postoperative complications: No complications, fistula, infection, unspecific failure, hemorrhage, healing by second intention; (5) Results of sinus lift procedure: failure or not; (6) Results of implant placement: failure or not.\n\nExclusion Criteria: (1) Medical history that was not fully complied with; (2) Patients who did not attend follow-up visits.",{"count":685,"type":23},400,"This retrospective study aims to evaluate clinical histories to determine if there is a relationship between patients allergic to penicillin and sinus lift failure and the possible post-operative complications that may arise.",[688],"Maxillary Sinus Disease",[690,691,692],"Penicillin allergy","Dental implant","Sinus lift failure","2024-07-16",{"date":695,"type":44},"2024-07-17",{"date":697,"type":44},"2004-07-01",{"date":699,"type":23},"2024-12-31",{"name":50,"class":51},""]