[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universite du Littoral Cote d'Opale\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":137},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,75,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100632618","brain-connectivity-and-corticospinal-excitability-in-response-to-moderate-hypoxia-100632618",false,"NCT07516028","Brain Connectivity and Corticospinal Excitability in Response to Moderate Hypoxia","NEUROXIE","Inclusion Criteria:\n\n* Male or female aged 18 to 65 years\n* Healthy right- or left-handed individuals with no self-reported neurological disorders or history of neurological conditions (e.g., epilepsy, stroke, brain or spinal surgery, or neurological diseases affecting motor or sensory function such as multiple sclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's)\n* Individuals who have provided informed consent and have sufficient proficiency in French\n* Participants affiliated with, or beneficiaries of, a social security scheme\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than 30 kg\u002Fm²\n* Diagnosed and untreated obstructive sleep apnoea syndrome\n* Inability to provide informed consent\n* History of cardiac (e.g., ischaemic heart disease, heart failure) and\u002For respiratory disorders (e.g., COPD, chronic respiratory insufficiency, persistent or uncontrolled asthma)\n* Current smokers\n* Contraindications to TMS (e.g., uncontrolled epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, implanted stimulator or pump, scalp lesions, elevated intracranial pressure, cerebrospinal fluid shunt)\n* Use of psychotropic medication\n* Individuals under legal guardianship or curatorship\n* Pregnant or breastfeeding women\n* Participants who have flown by air or travelled to terrestrial altitudes above 1500 metres within the seven days prior to inclusion",true,"ALL","18 Years","65 Years",{"count":21,"type":22},36,"ESTIMATED","INTERVENTIONAL",[25],"NA","Hypoxia, defined as a reduction in the availability of oxygen, induces significant physiological adaptations. While the deleterious effects of severe and chronic hypoxia are well documented, several studies indicate that moderate hypoxia - particularly when administered intermittently - may produce beneficial effects on cardiometabolic health (e.g., improved regulation of blood pressure and better glycaemic control). However, its impact on the dynamics of brain circuits in humans remains relatively underexplored. The present project aims to characterise the effects of continuous and intermittent moderate hypoxia on resting-state brain dynamics in healthy adults. To this end, simultaneous electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) recordings will be conducted in order to extract functional and haemodynamic markers of brain activity. This project will contribute to a better understanding of the neurophysiological mechanisms associated with hypoxic conditioning and to the assessment of its potential application in innovative therapeutic approaches.",[28,29,30],"Normoxia","Intermittent Moderate Hypoxia","Continuous Moderate Hypoxia",[32,33,34,35,36],"hypoxia","eeg","fnirs","motor-evoked potentials","tms","NOT_YET_RECRUITING","2026-04-02",{"date":40,"type":41},"2026-04-07","ACTUAL",{"date":43,"type":22},"2026-03-15",{"date":45,"type":22},"2026-12-20",{"name":47,"class":48},"Universite du Littoral Cote d'Opale","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":49},"100627963","cortical-excitability-during-de-novo-motor-learning-100627963","NCT07455461","Cortical Excitability During de Novo Motor Learning","Cortical Excitability During de Novo Motor Learning in Healthy Subjects : an Exploratory Longitudinal Study","StimNovoLearn","Inclusion Criteria:\n\n* right-handed\n* healthy\n* having signed an informed consent form\n\nExclusion Criteria:\n\n* counter-indication to transcranial magnetic stimulation\n* pregnancy","35 Years",{"count":60,"type":22},40,[25],"De novo motor learning is a specific learning paradigm that allows investigation of how a new motor skill is learned from scratch. Motor task learning can induce increased corticospinal excitability and reorganization of connectivity observed within the motor cortex (M1). Several studies have investigated the plasticity mechanisms underlying motor learning using simple paradigms. The results obtained have been variable, with a major trend toward increased corticospinal excitability, while other results show no increase. We expect to observe a significant increase in excitability and enhanced intracortical reorganization mechanisms within M1 in our subjects during our de novo motor learning sessions.\n\nThe primary objective of this study is to measure changes in corticospinal excitability of the motor system across 3 de novo motor learning sessions separated by different time intervals.\n\nThe secondary objectives will be: 1) to measure learning across the three practice sessions, 2) to measure changes in inhibition and facilitation across the 3 learning sessions, and 3) to measure correlations between subjects' motor performance and corticospinal and intracortical changes.",[64,65],"Motor Learning","Corticospinal Excitability","RECRUITING","2026-03-02",{"date":69,"type":41},"2026-03-06",{"date":71,"type":22},"2026-02-25",{"date":73,"type":22},"2027-06",{"name":47,"class":48},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":16,"sex":17,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":49},"100626682","influence-of-physical-exercise-on-neuroplasticity-and-sensorimotor-networks-in-older-adults-100626682","NCT07438808","Influence of Physical Exercise on Neuroplasticity and Sensorimotor Networks in Older Adults","EXOPLASTIC","Inclusion Criteria:\n\n* Men or women aged 20 to 35 for the younger group and 65 to 80 for the older group.\n* Healthy right-handed or left-handed subjects.\n* Subjects who have signed an informed consent form.\n* Ability to understand spoken and written French to follow study procedures.\n* Subjects affiliated with or beneficiaries of a social security system.\n\nExclusion Criteria:\n\n* History of psychaitric disorders : individuals with mental retardation or severe impairment of cognitive, behavioral, or emotional functions that prevent them from understanding the protocol and signing the informed consent form.\n* Neurological history (epilepsy, stroke, brain or spinal cord surgery, and history of neurological diseases affecting motor skills and sensitivity, such as multiple sclerosis, neurodegenerative diseases such as Parkinson's or Alzheimer's).\n* Inability to give informed consent (e.g., dementia, significant hearing impairment, insufficient language proficiency).\n* Contraindications to TMS and tDCS : uncontrolled epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, implanted stimulator or pump, scalp skin lesion, high intracranial pressure, cerebrospinal fluid shunt).\n* Presence of a cardiac pacemaker or other implanted electronic medical device.\n* Use of psychotropic drugs.\n* Individuals under legal guardianship or curatorship.\n* Pregnant and breastfeeding women.\n* Inability or recognized contraindication to physical activity.","20 Years","80 Years",{"count":85,"type":22},66,[25],"The purpose of this study is to investigate the influence of a single session of moderate aerobic exercise on motor cortex neuroplasticity in older adults, both alone and in combination with transcranial direct current stimulation (tDCS), and to compare these effects with those observed in young adults.\n\nNormal aging is associated with changes in the central nervous system that can affect motor function, sensorimotor integration, and cortical inhibitory mechanisms. These alterations may reduce the brain's capacity for neuroplasticity, which is essential for motor learning and functional adaptation. Physical exercise has been proposed as a potential strategy to counteract age-related decline in neuroplasticity.\n\nIn this study, healthy young and older adults will participate in three experimental sessions. Participants will complete two experimental conditions in a randomized crossover design: (1) aerobic exercise followed by transcranial direct current stimulation (tDCS), and (2) physical inactivity followed by tDCS and a third session will assess the effects of exercise alone. Moderate aerobic exercise will consist of 20 minutes of cycling on an ergometer.\n\nCorticospinal excitability and intracortical and sensorimotor circuit function will be assessed using transcranial magnetic stimulation (TMS) before and after each intervention. Neuroplasticity will be evaluated by measuring changes in motor evoked potentials recorded from a hand muscle of the dominant side.\n\nThe primary objective is to determine whether aerobic exercise enhances tDCS-induced plasticity, and whether this enhancement differs between young and older adults. Secondary objectives include evaluating age-related differences in intracortical inhibitory and facilitatory mechanisms and sensorimotor integration processes.\n\nBy improving understanding of how exercise interacts with brain stimulation to modulate motor cortex plasticity, this study may help inform strategies aimed at preserving motor function and functional independence in aging populations.",[89,90,91],"tDCS","Physical Activity + tDCS","Physical Inactivity + tDCS",[89,65,93,94,95],"Transcranial Magnetic Stimulation","Physical Exercise","Aerobic Exercise","2026-02-22",{"date":98,"type":41},"2026-02-27",{"date":100,"type":22},"2026-02-04",{"date":102,"type":22},"2026-07",{"name":47,"class":48},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":49},"100602560","integrating-art-therapy-and-adapted-physical-activity-toward-improved-quality-of-life-in-patients-with-myasthenia-gravis-100602560","NCT07125105","Integrating Art Therapy and Adapted Physical Activity: Toward Improved Quality of Life in Patients With Myasthenia Gravis","APART-MG","Inclusion Criteria:\n\n* Confirmed diagnosis of myasthenia gravis of any form established by a referring neurologist.\n* Patients followed at Lille University Hospital and its partners (Neuromuscular Diseases Reference Center, hospitals of the Côte d'Opale, home care services), or at Amiens University Hospital.\n* No major contraindications to participating in adapted physical activity and\u002For art therapy, as evaluated by the medical team.\n* Availability to attend all 10 sessions of the APA-only program and the combined APA + AT program, according to the cross-over design.\n* Signed informed consent after being informed about the objectives and requirements of the project.\n\nExclusion Criteria:\n\n* Severe comorbidities limiting participation in adapted physical activity or art therapy.\n* Advanced cognitive decline or severe neuropsychiatric disorders preventing understanding and participation.\n* Unstable medical treatment with recent changes that may affect fatigability or physical capacity \u002F poorly controlled myasthenia gravis.\n* Physical inability to participate in adapted physical activity or art therapy, even with adaptations.\n* Unavailability to complete the entire protocol (e.g., relocation, prolonged absence).\n* Refusal or inability to provide informed consent (e.g., patient under guardianship without legal authorization).\n* Difficulty accessing the intervention locations without possible alternatives such as remote or home-based sessions.",{"count":112,"type":22},102,[25],"Myasthenia Gravis (MG) is a rare neuromuscular disease characterized by fluctuating muscle weakness and excessive fatigability. Although medical treatments have improved, MG continues to significantly impact patients' physical, emotional, and social well-being. Current care primarily focuses on symptom management, often overlooking the broader psychosocial needs of patients.\n\nThis study explores an innovative and holistic approach combining Adapted Physical Activity (APA) and Art Therapy (AT) to improve quality of life in adults with MG. The intervention includes two 6-week phases in a crossover design: one with APA alone and one combining APA with personalized AT sessions focused on body awareness, movement, and creative expression.\n\nThe investigators hypothesize that the addition of AT to a standardized APA program will significantly enhance patients' engagement and well-being, resulting in improved quality of life, reduced fatigue, and better mental health outcomes.\n\nA total of 102 adult participants will be recruited from several hospitals in northern France (Lille, Dunkerque, Calais, Boulogne-sur-Mer, and Saint-Omer). Participants will be randomly assigned to begin with either APA alone or APA+AT. All interventions are tailored to the specific needs of MG patients and will be delivered both in person and online, depending on participant needs.\n\nOutcomes will be evaluated using standardized questionnaires (e.g., MG-QOL15, FSS, HADS), physical performance tests (e.g., handgrip strength, sit-to-stand), and accelerometry. Qualitative data will be collected through semi-structured interviews, ethnographic observations and art based research to better understand patients' experiences.\n\nThe study has received ethical approval from the French National Ethics Committee (CPP) and involves minimal risk. Participation is voluntary, with no financial compensation. This protocol may pave the way for broader application of APA+AT models in other rare or chronic conditions that involve fluctuating fatigue and psychosocial complexity.",[116],"Myasthenia Gravis",[116,118,119,120,121,122,123,124,125,126,127,128],"Art Therapy","Adapted Physical Activity","Randomized","Rare Neuromuscular Diseases","Crossover Trial","Quality of Life","Psychosocial Intervention","Fatigue in Chronic Illness","Mental Health in Rare Diseases","Non-pharmacological Interventions","Dramatherapy","2025-08-07",{"date":131,"type":41},"2025-08-15",{"date":133,"type":22},"2025-11-01",{"date":135,"type":22},"2028-10-30",{"name":47,"class":48},""]