[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universiti Malaysia Sabah\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":114},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100623769","brain-stimulation-combined-with-watching-hand-movements-to-improve-hand-recovery-in-chronic-stroke-100623769",false,"NCT07400939","Brain Stimulation Combined With Watching Hand Movements to Improve Hand Recovery in Chronic Stroke","Investigating The Neurophysiological Mechanisms Of Transcranial Direct Current Stimulation Combined With Action Observation Therapy On Hand Muscle Neuroplasticity in Chronic Stroke","Inclusion Criteria:\n\n* Adults aged 18 to 59 years\n* Single episode of unilateral stroke and weakness in hand muscles 6 to 24 months post-stroke\n* No excessive spasticity of the upper limb, defined as grade two or less on Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Patients diagnosed with posterior circulation infarction\n* Unable to follow commands due to poor cognitive function\n* Unilateral neglect\n* Homonymous hemianopia\n* Other existing neurological disorders that lead to poor hand function\n* Grade four or five hand muscle strength.","ALL","18 Years","59 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates the neurophysiological mechanisms underlying the combined use of transcranial direct current stimulation (tDCS) and action observation therapy (AOT) for hand motor recovery in individuals with stroke. Background: While both tDCS and AOT have shown promise individually for stroke rehabilitation, the neural mechanisms of their combined effects remain unclear. Understanding these mechanisms could optimise rehabilitation protocols and improve functional outcomes. Intervention: Participants will receive 10 sessions of anodal tDCS over the ipsilesional motor cortex combined with AOT over two weeks in a clinical setting, followed by 8 weeks of home-based AOT practice. Control groups will receive tDCS alone or AOT alone. Neurophysiological changes will be assessed using motor evoked potentials (MEPs) to evaluate corticospinal excitability. Clinical hand function will be assessed using standardised outcome measures. Measurements: Assessments will be conducted at baseline, during intervention (week 2), and after the home practice phase (week 10) to evaluate neuroplastic changes. Significance: This study will provide mechanistic insights into how neuromodulation and observational learning interact to promote motor recovery, informing evidence-based rehabilitation strategies for stroke survivors in Malaysia and globally. Study Design: Randomised controlled trial with three parallel arms, recruiting 60 participants with chronic stroke from Sabah, Malaysia.",[27,28,29,30,31,32,33,34],"Stroke","tDCS","Action Observation Therapy","Hand","Motor Evoked Potential","EMG","Neuroplasticity","Neurophysiological Assessment",[36,37,38,39,40],"stroke rehabilitation","transcranial direct current stimulation","action observation therapy","neuroplasticity","neurophysiological","RECRUITING","2026-05-07",{"date":44,"type":45},"2026-05-12","ACTUAL",{"date":47,"type":45},"2026-04-01",{"date":49,"type":21},"2028-01-20",{"name":51,"class":52},"Universiti Malaysia Sabah","OTHER",2,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},"100561239","effectiveness-of-text-messaging-intervention-to-improve-dietary-behaviors-among-patients-with-type-2-diabetes-mellitus-in-low-resource-area-of-sabah-dtext-sbh-100561239","NCT06587581","Effectiveness of Text Messaging Intervention to Improve Dietary Behaviors Among Patients with Type 2 Diabetes Mellitus in Low Resource Area of Sabah (DTEXT-SBH)","Effectiveness of Text Messaging Intervention to Improve Dietary Behaviors Among Patients with Type 2 Diabetes Mellitus in Low Resource Area of Sabah: a Randomized, Open-Label, Controlled Trial","DTEXT-SBH","Inclusion Criteria:\n\n* have type 2 diabetes.\n* own a mobile phone.\n* able to use WhatsApp.\n* able to read and speak Bahasa Malaysia.\n* have an HbA1c level above 7.0%.\n* have not seen a dietitian in the previous 6 months.\n\nExclusion Criteria:\n\n* individuals with type 1 diabetes mellitus and gestational diabetes mellitus.\n* patients with cognitive impairment affecting memory, attention, language, and problem-solving skills.\n* those with advanced diabetic complications, such as kidney failure and neuropathy.\n* individuals lacking regular access to a mobile phone or with poor network connectivity.\n* pregnant individuals or those planning to get pregnant in the next 6 months, as well as those currently nursing.\n* individuals with major illnesses like cancer or advanced heart disease.\n* those planning major surgery or gastric bypass in the next 6 months.\n* institutionalized individuals, such as those in nursing homes, old folks\\' homes, or imprisoned.","60 Years",{"count":64,"type":21},62,[24],"The goal of this clinical trial is to learn if sending three (3) text messages per week over a six (6) months period to people with Type 2 Diabetes in areas with lack access to dietitian could help them stick to a healthier diet. The main questions it aims to answer are:\n\n* Does a mobile phone text-message intervention improve dietary adherence among T2DM patients?\n* Does a mobile phone text-message intervention improve HbA1c and self-management among T2DM patients? Researchers will compare dietary adherence, HbA1c changes and self-management behaviors between the usual care group and intervention group.\n\nParticipants will:\n\n* Be given three (3) text messages per week over a six (6) months period for the intervention group\n* Both usual care and intervention group will be given standard medical nutrition therapy at baseline, 3rd and 6th months visits to the clinic",[68],"Type 2 Diabetes Mellitus(T2DM)",[70,71,72,73,74],"type 2 diabetes mellitus","lack access to dietitian","eHealth","Dietary adherence","low resource area","NOT_YET_RECRUITING","2024-09-05",{"date":78,"type":45},"2024-09-19",{"date":80,"type":21},"2025-01",{"date":82,"type":21},"2025-07",{"name":51,"class":52},1,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":4},"100559868","effects-of-homemade-oral-nutrition-supplements-for-patients-on-hemodialysis-with-protein-energy-wasting-100559868","NCT06569732","Effects of Homemade Oral Nutrition Supplements for Patients on Hemodialysis With Protein-energy Wasting","Clinical Efficacy, Feasibility, and Cost-effectiveness of Homemade Oral Nutrition Supplements on Patients on Hemodialysis With Protein-energy Wasting: a Parallel, Open-labeled, Randomized Controlled Trial","HOMES-HD","Inclusion Criteria:\n\n* on maintenance HD dialysis treatment (thrice weekly and 4-hour per session) for at least three months\n* age 18 - 70 year old\n* diagnosed with protein energy wasting using the malnutrition inflammation score (≥ 5)\n\nExclusion Criteria:\n\n* a history of poor adherence to HD treatment (frequently miss the HD treatment for more than one session every month)\n* a history of frequent hospitalization (more than once in the past one month)\n* on regular oral nutrition supplements\n* diagnosed with malignancy\n* pregnant or lactating women\n* allergic to study products such as soy milk or milk","70 Years",{"count":95,"type":21},40,[24],"The goal of this clinical trial is to learn if homemade oral nutrition supplements works to treat protein energy wasting in patients on hemodialysis. It will also learn about the cost-effectiveness of homemade oral nutrition supplements. The main questions it aims to answer are:\n\n* Does homemade oral nutrition supplements improve the nutritional status of patients on hemodialysis with protein energy wasting?\n* What is the cost-effectiveness of homemade oral nutrition supplements?\n\nResearchers will compare homemade oral nutrition supplements to commercial oral nutrition supplements to see if homemade oral nutrition supplements works to treat protein energy wasting in patients on hemodialysis.\n\nParticipants will:\n\n* Take homemade or commercial oral nutrition supplements every day for 6 months\n* Have assessment of nutritional status performed by researchers every three monthly",[99,100,101],"Protein-Energy Wasting","Kidney Failure","Hemodialysis",[103,104,105],"hemodialysis","protein-energy wasting","kidney failure","2024-08-23",{"date":108,"type":45},"2024-08-26",{"date":110,"type":21},"2024-11",{"date":112,"type":21},"2025-11",{"name":51,"class":52},""]