[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University Heart Center Freiburg - Bad Krozingen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":62},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100623650","radial-versus-femoral-secondary-access-in-patients-undergoing-tavi-100623650",false,"NCT07399392","Radial Versus Femoral Secondary Access in Patients Undergoing TAVI","RADIAL-TAVI","Inclusion Criteria:\n\n* Patients scheduled for transfemoral TAVI\n* Heart team agrees on eligibility of TAVI\n* Written informed consent\n* Age \\> 18 years\n\nExclusion Criteria:\n\n* Non accessible radial arteries as judged by the TAVI team\n* Non accessible femoral arteries as judged by the TAVI team\n* Foreseeable problems to achieve primary transfemoral access (hostile access)\n* Hemodynamic instability or cardiogenic shock\n* Currently participating in an investigational drug or another device study\n* Lack of capability to give informed consent\n* Patient refuses TAVI","ALL","18 Years",{"count":19,"type":20},600,"ESTIMATED","INTERVENTIONAL",[23],"NA","Severe symptomatic aortic stenosis (AS) with a high gradient is associated with a poor prognosis if not treated with valve replacement. Transcatheter aortic valve implantation has been shown in large randomized trials to be a safe and effective treatment option for patients at low, intermediate, or high risk. Transfemoral access for heart valve replacement is by far the most commonly used approach, as it is relatively easy to control and has a low complication rate compared to other access routes.\n\nThe TAVI procedure requires two arterial access points: one with a large lumen for the TAVI prosthesis via the femoral artery, and a smaller second one for a pigtail catheter that guides the TAVI prosthesis into the optimal position. This secondary access is most often via a second artery.\n\nVascular complications are the most commonly observed complications in transfemoral TAVI and are associated with poorer procedural outcomes.\n\nRecent data suggest that secondary vascular access via the radial artery may contribute to a reduction in vascular complications after TAVI. In patients undergoing coronary angiography and\u002For percutaneous coronary intervention, radial access has become the preferred strategy due to its proven reduction in vascular complications compared to femoral access. The use of radial access is associated with a lower incidence of vascular complications compared to femoral access.\n\nRecent non-randomized data suggest that radial access may be a safer alternative to traditional femoral access as a secondary arterial access in transfemoral TAVI. However, non-randomized retrospective comparisons are subject to selection bias and underreporting of complications. Therefore, a prospective randomized trial is needed to evaluate the value of radial access for secondary arterial access in patients undergoing transfemoral TAVI.",[26],"TAVI(Transcatheter Aortic Valve Implantation)","RECRUITING","2026-06-01",{"date":30,"type":31},"2026-06-02","ACTUAL",{"date":33,"type":31},"2025-07-01",{"date":35,"type":20},"2028-12-31",{"name":37,"class":38},"University Heart Center Freiburg - Bad Krozingen","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":48,"phases":4,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":61},"100632578","multimodal-phenotyping-in-patients-referred-with-acute-cardiac-failure-100632578","NCT07515508","Multimodal Phenotyping In Patients Referred With Acute Cardiac faiLurE","MIRACLE","Inclusion Criteria:\n\n* Patients hospitalized with acute heart failure SCAI stage B - E.\n\nExclusion Criteria:\n\n* Not capable of providing informed consent due to reasons not attributable to cardiogenic shock\n* Cardiogenic shock following cardiothoracic surgery",{"count":19,"type":20},"OBSERVATIONAL","The goal of this observational study is to learn whether information collected during routine hospital care, together with blood and urine samples, can help doctors better identify different types of cardiogenic shock and better predict outcomes in adults hospitalized with acute heart failure and cardiogenic shock. The main question is whether clinical findings, imaging results, and biomarkers, including sex-specific factors, are associated with the risk of death within 30 days. Participants will not receive an experimental treatment. Researchers will collect data from routine care, collect additional blood and urine samples for biobanking, and follow participants after hospital discharge",[51,52],"Cardiogenic Shock","Acute Heart Failure (AHF)","2026-03-31",{"date":55,"type":31},"2026-04-07",{"date":57,"type":31},"2024-08-07",{"date":59,"type":20},"2028-07-31",{"name":37,"class":38},4,""]