[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University Hospital, Caen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":671},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,68,0,25,[9,49,71,92,121,142,169,194,220,248,273,299,327,350,377,397,427,466,486,512,534,568,587,616,647],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100619508","exploratory-study-of-the-myheartsentinel-system-a-cardiametrics-medical-device-100619508",false,"NCT07345533","EXPLORATORY STUDY OF THE MYHEARTSENTINEL SYSTEM, A CARDIAMETRICS MEDICAL DEVICE","EXPLORATORY STUDY OF THE MYHEARTSENTINEL SYSTEM, A CARDIAMETRICS MEDICAL DEVICE - ANALYSIS OF CARDIAC ELECTROPHYSIOLOGICAL AND MECHANICAL SIGNALS DURING A DECOMPENSATION\u002FRECOMPENSATION EPISODE IN PATIENTS WITH HEART FAILURE IN THE HOSPITAL AND UPON DISCHARGE HOME","ASEMC-DR","Inclusion Criteria:\n\n* Patients aged between 18 and 90 years\n* Affiliated with the social security system.\n* Patients who have been informed of the study and have signed informed consent.\n* Patients with heart failure and one of the following two criteria:\n\n  * Hospitalized for hemodynamic assessment\n  * Hospitalized in a cardiology unit (ICU or telemetry unit) for congestive decompensation of known heart failure defined by \\[8\\] minimal dyspnea at rest or during exercise AND an elevation of BNP \\> 400 µg\u002Fml or NT-proBNP \\> 1600 µg\u002Fml\n\nExclusion Criteria:\n\n* Patient hospitalized for decompensated heart failure due to an infectious cause requiring antibiotic treatment\n* Patient requiring intravenous inotropes within the last 24 hours\n* Patient with ventricular arrhythmias or permanent AF\n* ACS with ST+ complex complicated by heart failure\n* Valvulopathy awaiting interventional management\n* Pericardial constriction\n* Pregnant or breastfeeding women\n* Women of childbearing potential without effective contraception\n* Patients under guardianship, curatorship, legal protection, or legal protection.\n* Patients already enrolled in an interventional clinical trial that may impact the electrophysiological and cardiac mechanical measurements of the medical device under study. • Inability to position the sensor on the thoracic area of interest\n* Patients with open wounds, recent scars, or skin infections at the intended SCOUT device placement site\n* Patients suffering from dermatitis, eczema, psoriasis, or other skin conditions at the placement site.\n* Physical or psychological inability of the patient or caregiver to use the digital medical telemonitoring device and\u002For its collection accessories, as determined by the physician wishing to include the patient in the medical telemonitoring project;\n* Patient refusal to transmit the data necessary to monitor the effective use of the DMN and to obtain individualized or national real-life usage results;\n* Patient refusal to receive therapeutic support.","ALL","18 Years","90 Years",{"count":22,"type":23},70,"ESTIMATED","INTERVENTIONAL",[26],"NA","Background:\n\nChronic heart failure represents a major public health challenge, affecting approximately 64 million people worldwide and generating high costs in terms of mortality, frequent hospitalizations, and medical expenses. In France, this disease is expected to cause nearly 70,000 deaths and 181,000 hospital admissions in 2022. Current management, based on periodic consultations, fails to effectively prevent acute exacerbations, highlighting the importance of technological solutions such as remote monitoring.\n\nObjective:\n\nThis study aims to demonstrate the value of regular monitoring of electrophysiological and mechanical cardiac signals and parameters in patients with chronic heart failure. Its goal is to build a database of signals from an external measuring device (MyHeartSentinel MHS) to identify parameters that evolve in relation to biological and\u002For hemodynamic changes and\u002For the patient's clinical status. The results of this study will enable the further development of an automated monitoring solution for heart failure patients to enable early detection and management of decompensation.\n\nMaterials and Methods:\n\nA total of 70 patients diagnosed with chronic heart failure will be included, including 30 patients hospitalized for heart failure decompensation and 40 patients hospitalized for hemodynamic assessment. Electrophysiological and cardiac mechanical data will be collected using a skin-based measuring device. These data will then be correlated with biological and\u002For hemodynamic changes and\u002For the patient's clinical status. They will contribute to the training of an algorithm to detect the risk of decompensation.\n\nHypothesis Tested:\n\nAbility of MHS to detect electrophysiological and cardiac mechanical data related to cardiac decompensation, such as cardiac filling pressure.",[29,30,31],"Heart Failure","Telemonitoring","Right Heart Catheterisation",[30,33,34,35],"heart failure","right heart catheterisation","acute heart failure","RECRUITING","2026-06-24",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":40},"2025-07-17",{"date":44,"type":23},"2028-03-17",{"name":46,"class":47},"University Hospital, Caen","OTHER",1,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":48},"100589852","insulin-pump-versus-full-closed-loop-for-type-2-diabetes-100589852","NCT06959797","Insulin Pump Versus Full Closed-loop for Type 2 Diabetes","Randomized Cross-over Study Comparing Insulin Pump Versus Full Closed-loop Automated Insulin Therapy in Type 2 Diabetic Patients Previously Treated With Insulin Pumps","IA-DT2","Inclusion Criteria:\n\n* Age \\> 18\n* Type 2 diabetes for at least 12 months\n* On insulin pump for at least 6 months, without\u002Fwith adjuvant treatment exclusively with GLP1-Ra, iSGLT2, metformin for at least 3 months\n* Autonomy in the management of the pump and the glucose sensor\n* HbA1c ≥ 7.5% and \\\u003C 12\n* Participant's agreement to wear and use the Ypsomed with the CamAPS HX algorithm and Free Style Libre 3 sensor, and to honor the study visit schedule\n* For women of childbearing age, effective contraception is required (estrogen-progestin pill, IUD, implant).\n\nExclusion Criteria:\n\n* Type 1 diabetes or monogenic diabetes\n* Use of U500 or U200 insulin concentrate in the pump in the last 3 months\n* Allergy to insulin or to the adhesives used\n* Severe insulin resistance defined by a daily insulin requirement of more than 1.5 U\u002Fkg\n* History of severe hypoglycemia \\> 1 time in the last 6 months.\n* Current or planned use of steroids (oral, injectable) or any treatment likely to have an impact on blood glucose levels within the last 30 days.\n* Current or planned pregnancy, breastfeeding\n* Severe renal failure defined as GFR \\\u003C 30 ml\u002Fmn\n* Proliferative retinopathy or severe maculopathy with risk of worsening during the study\n* Vision or hearing problems that could compromise safe use of the device\n* Acute vascular event within the last 3 months\n* No autonomy for pump treatment\n* Alcohol or substance abuse\n* Legal protection (guardianship, curatorship)\n* Any somatic or psychological condition compromising participation in the study\n* Participation in another clinical trial",{"count":58,"type":23},80,[26],"The aim of the study is to compare, in a population of patients with type 2 diabetes, open-loop insulin pump treatment with the CamAPS HX (Camdiab) Fully Closed Loop Automated Insulin Therapy system, on the efficacy and safety of use of the Fully Closed Loop, as well as on psycho-social criteria of device acceptability, quality of life and diabetes burden. This is an open, multi-center, randomized, cross-over study, based on several observational or controlled trials carried out in Cambridge by Prof. Hovorka's team (see paragraph 4 below). The study will comprise a run-in phase followed by a 1st sequence in which randomized patients will use the Ypsomed pump (Ypsomed) and the FreeStyle Libre 3 sensor in open loop for 12 weeks Versus the Ypsomed pump (Ypsomed) coupled with the CamAPS HX algorithm and the FreeStyle Libre 3 sensor in full closed loop. At the end of this 1ère sequence, all patients will undergo a 2-4 week washout, during which they will use the Ypsomed pump and the FreeStyle Libre 3 sensor in open loop, and then in the 2nd sequence of the study, patients will switch to the other treatment for a further 12 weeks. A total of 80 patients on insulin pumps for at least 6 months will be recruited from 9 French centers. All patients will receive training in the use of the Ypsomed pump, the FreeStyle Libre 3 sensor and the CamAPS HX algorithm. The primary objective is Time on Target 70-180 mg\u002Fdl of 24h measured during the 12 weeks of each therapeutic period. Secondary objectives will be Time in Target 70-180 mg\u002Fdl day and night, Time above Target \\> 180 mg\u002Fdl and \\> 250 mg\u002Fdl, Time below Target \\\u003C 70 mg\u002Fdl and \\\u003C 54 mg\u002Fdl, time in the narrow target range 70-140 mg\u002FdL, mean 24h blood glucose and glycemic variability measured over the 12 weeks of each treatment sequence, HbA1c, weight, total insulin dose and psychosocial endpoints assessed at the start and end of each treatment sequence. Safety data studied will include diabetes-related adverse events (ketoacidosis, symptomatic and severe hypoglycemia) and medical device-related adverse events (pump and sensor).",[62],"Type 2 Diabetes",[64],"Type 2 diabetes, automated insulin therapy",{"date":39,"type":40},{"date":67,"type":40},"2025-05-05",{"date":69,"type":23},"2028-12-31",{"name":46,"class":47},{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":24,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":48},"100549260","correction-of-ear-deformities-in-newborns-by-modeling-comparison-of-two-protocols-100549260","NCT06431698","CORRECTION OF EAR DEFORMITIES IN NEWBORNS BY MODELING, COMPARISON OF TWO PROTOCOLS","MOLDEAR","Inclusion Criteria:\n\n* Newborn, age between 8 days and 1 month\n* newborn with ear malformation\n\nExclusion Criteria:\n\n* Total chondrocutaneous agenesis of the ear\n* polymalformative syndrome\n* age greater than 4 weeks\n* parental refusal","1 Month",{"count":80,"type":23},134,[26],"Evaluation of the non-inferiority of the custom-made device developed in the maxillofacial surgery department of Caen University Hospital compared to the device from the EarWell™ group",[84],"Ear Malformation",{"date":86,"type":40},"2026-06-25",{"date":88,"type":40},"2023-07-31",{"date":90,"type":23},"2028-07-31",{"name":46,"class":47},{"id":93,"slug":94,"hasResults":12,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":12,"sex":18,"minAge":100,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":24,"phases":103,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":115,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":48},"100363491","phase-3-giant-cell-arteritis-comparison-between-two-standardized-corticosteroids-tapering-100363491","NCT04012905","Giant Cell Arteritis: Comparison Between Two Standardized Corticosteroids Tapering","A Randomized, Controled, Open Label Trial: Comparison Between Two Standardized Corticosteroids Tapering, Respectively Short (North American) and Long (European), in Giant Cell Arteritis","CORTODOSE","Inclusion Criteria:\n\n* Age ≥ 50 years\n* Patient with temporal arteritis giant cell match 2 of the 4 criteria of the American College of Rheumatology (ACR) that given :\n\n  * a temporal artery biopsy compatible with a diagnosis of CAG or\n  * an abdominal thoracic aortitis diagnosed by Angio CT, MR angiography or PET scanner or\n  * Echo Doppler compatible with a diagnosis of CAG\n* Oral corticosteroid treatment started up to 14 days, the initial dose is less or equal to 1 mg \u002F Kg\n* Patient wo has given its written consent Patient affiliated with a social security\n\nExclusion Criteria:\n\nSubjects checking one of the criteria for non-inclusion may be eligible to participate in the research. These criteria may include:\n\n* Early treatment of CAG disease with a dose\\> 1 mg \u002F kg whatever the duration\n* Corticosteroids already started over 14 days\n* Giant arteritis cell on relapse\n* dementia syndrome\n* No compliant patient\n* Patients who live more than 150 km from the investigation center\n* Person under judicial protection, guardianship\n* Hypersensitivity to prednisone or any of its excipients\n* Infection requiring an systemic treatment\n* Evolutive viroses (Hepatitis, Herpes, varicella-zoster virus)\n* Immunization with live vaccines \u002F mitigated during the 8 weeks preceding inclusion\n* Pregnancy, breastfeeding women or women of childbearing potential not using contraception","50 Years",{"count":102,"type":23},150,[104],"PHASE3","Corticosteroid therapy has always been the standard treatment for giant cell arteritis (GCA), with very good initial clinical efficacy but a high relapse rate when it declines.\n\nThe target population of this condition, often elderly, is particularly exposed to the numerous undesirable effects of corticosteroid therapy, and this especially as its duration lengthens with the re-increases of doses according to relapses: metabolic complications, osteo-muscular , infectious or neuropsychiatric.\n\nInvestigators propose to compare prospectively the results of a \"conventional\" corticosteroid regimen as recommended by European societies, to those of a \"lighter and \u002F or shorter\" scheme, inspired by recent North American trials. , including the largest prospective global study in the field. Investigators hypothesize non-inferiority of the lightened regimen for relapse rate without relapse at S52, but with a decrease in treatment-related adverse events whose cumulative doses should be lower.\n\nInvestigators therefore plan to include prospectively over 3 years 150 patients, 75 for each of the two arms, with a newly diagnosed ACG. A randomization of the treatment arm will be performed and a predefined pattern of cortisone adapted to body weight will be given to the patient. Relapse rates, maintenance of remission, cumulative doses of cortisone and adverse effects of treatment will be analyzed at the 52nd week of the introduction of corticosteroid therapy. An interim analysis is planned at S28.",[107],"Giant Cell Arteritis",[107,109,110,111,112,113,114],"Horton disease","Corticosteroids treatment","Prednisone","Relapse","Side effect","Cumulative doses",{"date":39,"type":40},{"date":117,"type":40},"2021-03-03",{"date":119,"type":23},"2029-05-03",{"name":46,"class":47},{"id":122,"slug":123,"hasResults":12,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":24,"phases":129,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":48},"100584983","innovative-osa-screening-in-head-and-neck-cancer-patients-with-the-apneal-app-100584983","NCT06896448","Innovative OSA Screening in Head and Neck Cancer Patients With the Apneal App","Inclusion Criteria:\n\n* Adult patients undergoing diagnostic workup for a lesion suspected to be a head and neck cancer, followed by confirmation of the malignant nature of the lesion. The following locations will be included: the nasopharynx, nasal cavities, sinuses, oral cavity, oropharynx, hypopharynx, larynx, and parotid gland.\n* The collection of the informed consent signature is required.\n* The patient must be affiliated with the social security system.\n\nExclusion Criteria:\n\n* Minor patients, or those under judicial protection, guardianship, or curators.\n* Lack of confirmation of the malignant nature of the lesion.\n* Diagnosis of metastatic cancer.\n* Known history of obstructive sleep apnea syndrome (OSAS) or previously treated head and neck cancer.",{"count":128,"type":23},20,[26],"Obstructive sleep apnea syndrome is a common but often underdiagnosed condition, with significant impacts on quality of life, such as fatigue, attention disorders, and an increased risk of heart attack or stroke. Structural changes in the head and neck region appear to contribute to the onset or worsening of this condition.\n\nTo improve patients' quality of life, early diagnosis is essential. Currently, diagnosis relies on expensive devices, often associated with long waiting times. To address these challenges, an innovative solution is proposed: a smartphone application enabling a simple and accessible diagnosis. This application is currently under validation and has not yet been commercialized.\n\nThe purpose of the study is to determine whether this smartphone application can be used in clinical practice for patients with a head and neck lesion to diagnose sleep apnea syndrome and to assess its progression during the medical care. This study is for patients who present a head and neck lesion currently under evaluation in our department at Caen University Hospital.\n\nThis research will be integrated into routine follow-up for a period of six months.\n\nThe medical device used in this study, Apneal, is a smartphone application currently undergoing validation for the rapid diagnosis of sleep apnea syndrome. Its use is simple: the smartphone is placed in airplane mode and secured to the chest overnight. Using the phone's built-in sensors, respiratory sleep data is collected and analyzed.\n\nAs part of the initial assessment, a dedicated sleep consultation is included, during which a few questionnaires are completed, followed by an overnight sleep recording using the Apneal application. This will be conducted at the beginning of the care during the assessment phase and again six months after the completion of any potential treatment.\n\nDepending on the results, if they are inconclusive, an additional sleep recording may be required using a ventilatory polygraphy device.\n\nThis study involves only two overnight recordings with a smartphone secured to the chest, which we will set up during the consultation.",[132,133],"Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)","Head and Neck Cancers","2026-06-17",{"date":136,"type":40},"2026-06-18",{"date":138,"type":40},"2025-09-16",{"date":140,"type":23},"2027-09-16",{"name":46,"class":47},{"id":143,"slug":144,"hasResults":12,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":24,"phases":153,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":48},"100506925","pilot-and-descriptive-study-of-the-effects-of-setting-up-computer-assisted-music-cam-remediation-groups-on-the-cognitive-functioning-of-young-patients-with-a-first-episode-psychosis-pep-100506925","NCT05880719","Pilot and Descriptive Study of the Effects of Setting up Computer-assisted Music (CAM) Remediation Groups on the Cognitive Functioning of Young Patients With a First Episode Psychosis (PEP)","Pilot and Descriptive Study of the Effects of the Implementation of Computer Assisted Music Remediation Groups on the Cognitive Functioning of Young Patients Presenting a First Episode Psychosis","MAOPEP","Inclusion Criteria:\n\n* Patient aged 18 to 30 years.\n* Consult for a first psychotic episode according to the criteria of the DSM-V\n* Francophone patient\n* With at least one memory deficit highlighted at the neuropsychological assessment of entry into the EMSI\n* Benefiting from a follow-up within the EMSI\n* Affiliated to the social security system\n* Clinically stabilized patient one month away from psychiatric hospitalization\n* Patient who has been informed of the study and has given his informed consent.\n\nExclusion Criteria:\n\nInability to give the patient informed information\n\n* Not meeting the criteria of the DSM-V of first episode of psychosis\n* Absence of memory cognitive disorders at the neuropsychological assessment of entry into the EMSI department.\n* Patient who has already had cognitive remediation in his EMSI management.\n* Patients under judicial protection measure (guardianship or curatorship).","30 Years",{"count":152,"type":23},30,[26],"The use of music in the field of cognitive remediation is growing and much research has focused on the relevance and effectiveness of its use in care. Studies have therefore made it possible to show the relevance of the use of musical material in the remediation of patients with various pathologies with cognitive disorders (head trauma, stroke, Alzheimer's disease). Although cognitive remediation has been widely studied in patients with schizophrenia, few studies suggest the effects of remediation in patients with a first psychotic episode. No study currently demonstrates the relevance of this material in the remediation of young people presenting a first psychotic episode.\n\nThe Mobile Intensive Care Team of the Adult Psychiatry Service of the CHU de Caen (EMSI) takes care of patients who have presented with a first psychotic episode. Young people entering an emerging psychosis frequently exhibit cognitive impairment. These attacks are variable and can concern memory, attentional and executive functioning. The most frequent disorders concern memory functioning and it is important to deal with them early in order to improve the functional prognosis of the young person.\n\nWe therefore propose the establishment of cognitive remediation groups through the MAO with patients treated by EMSI. These groups would aim to heal memory, attention and executive functions through exercises and musical practice through the Ableton © software. We therefore propose a study that would assess the effects of these workshops on the cognitive functioning of patients with memory difficulties. Attentional and executive functioning as well as self-esteem and negative symptoms will also be assessed.\n\nThis remedy will be offered in groups of 4. In this feasibility study, 30 patients will be included depending on the inclusion and monitoring capacities of the center. Ten weekly sessions of one hour per group over a period of 3 months will be applied. To assess the beneficial effects of this group remediation, assessments will be carried out at the start of the study and at the end of the 10 sessions.\n\nThe aim of this study is to assess the effects of an CAM remediation group on cognitive functioning, mood and self-esteem in patients who presented with a first psychotic episode.",[156],"Psychotic Episode",[158,159,160,161],"Music","Computer Aided Music","Memory","First Psychotic Episode",{"date":163,"type":40},"2026-06-22",{"date":165,"type":40},"2023-05-25",{"date":167,"type":23},"2028-06-30",{"name":46,"class":47},{"id":170,"slug":171,"hasResults":12,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":178,"phases":4,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":191,"leadSponsor":193,"locationsCount":4},"100640514","risk-prediction-scores-for-cardiotoxicity-in-cancer-patients-treated-with-cardiotoxic-anticancer-therapies-in-europe-100640514","NCT07621289","Risk Prediction Scores for Cardiotoxicity in Cancer Patients Treated With Cardiotoxic Anticancer Therapies in Europe","EUCARTOXSCORES","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of cancer\n* Planned cardio-oncology follow-up as part of pre-treatment assessment prior to cardiotoxic anticancer therapy, as defined in the 2022 ESC Cardio-Oncology Guidelines\n\nExclusion Criteria:\n\n* Patients for whom 12-month follow-up is planned to be conducted outside the center that performed the baseline pre-treatment evaluation",{"count":177,"type":23},10000,"OBSERVATIONAL","Cancer management has undergone major advances over the past 30 years. Several anticancer therapies are now highly effective, allowing many cancers to become chronic diseases through sequential lines of treatment. However, these therapies may be associated with severe cardiovascular adverse events.\n\nIt is therefore essential to better understand the factors that determine, for a given patient and a given anticancer therapy, the occurrence of cardiovascular toxicity, and ideally to predict which patients are at highest risk.\n\nThe 2022 ESC Cardio-Oncology Guidelines strongly recommend risk stratification prior to the initiation of cardiotoxic anticancer therapies. Current recommendations suggest the use of risk scores known as \"HFA-ICOS\" scores. However:\n\nNot all cardiotoxic anticancer therapies currently have an associated risk score; Existing scores are derived from small retrospective or prospective cohorts (typically fewer than 100 patients), and most have not undergone rigorous validation, leaving considerable room for improvement.\n\nThe EU-CARTOX-SCORES protocol aims to develop new prediction scores for cardiotoxicity occurring within the first year after initiation of cardiotoxic anticancer therapies. This protocol is innovative through the integration of artificial intelligence and\u002For machine learning approaches alongside conventional statistical methods. These models will be interfaced with a dedicated cardio-oncology digital platform (CardioOncoPilot), currently being deployed across the European Union, ensuring standardized and high-quality data collection within routine clinical care.\n\nThis is a prospective, multicenter, observational study designed as a European cardio-oncology registry, involving all European cardiologists using the platform in routine practice. The inclusion period will last 3 years, with a 12-month follow-up for each patient. At the time of data extraction, all available cases recorded in the CardioOncoPilot platform will be analyzed.\n\nOverall, it is anticipated that between 1,000 and 5,000 patients across Europe will be included by the end of 2027. These patients will be managed in cardio-oncology clinics as part of routine care during treatment with cardiotoxic anticancer therapies, with follow-up conducted at the same center throughout the study.\n\nThe primary endpoint will be the occurrence of cardiotoxicity as defined by the 2022 ESC Guidelines. Additionally, the performance of newly developed prediction models will be compared with existing HFA-ICOS risk scores (when available) in the same patient population.\n\nPatients will be followed according to routine clinical practice and in accordance with the 2022 ESC Cardio-Oncology Guidelines, which recommend both a baseline pre-treatment assessment and a follow-up evaluation at 1 year, regardless of the type of cardiotoxic therapy.\n\nPatient management will not be modified by the study. This research will consist solely of secondary use of data collected during routine care.\n\nWe anticipate that this study will significantly improve prognostic risk stratification tools in patients treated with cardiotoxic anticancer therapies, thereby enhancing identification of those at highest risk of clinically relevant cardiovascular adverse events during follow-up.\n\nThis project will be conducted in collaboration with the ESC Council of Cardio-Oncology, chaired by Prof. Teresa Lopez-Fernandez, ensuring optimal dissemination through appropriate scientific channels. The developed scores will be shared with the scientific community, particularly the European Society of Cardiology (ESC), with the aim of informing future guideline updates.",[181,182,183,184,185],"Cancer","Anticancer Treatment","Cardiovascular Disease Risk Factor","Cardiovascular Diseases","Hematological Malignancies","NOT_YET_RECRUITING","2026-05-27",{"date":189,"type":40},"2026-06-02",{"date":163,"type":23},{"date":192,"type":23},"2030-12-31",{"name":46,"class":47},{"id":195,"slug":196,"hasResults":12,"nctId":197,"briefTitle":198,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":178,"phases":4,"briefSummary":203,"conditions":204,"keywords":206,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":219},"100634102","study-of-patient-preferences-in-dialysis-treatment-choice-a-discrete-choice-experiment-100634102","NCT07535320","Study of Patient Preferences in Dialysis Treatment Choice: a Discrete Choice Experiment","PREFDOM","Inclusion Criteria:\n\n* Adult patient\n* Patient with advanced chronic kidney disease receiving pre-surgery information (presentation of methods)\n* Patient enrolled in a social security program\n* Patient able to read and understand French\n* Patient able to complete the questionnaire (cognitive and sensory)\n\nExclusion Criteria:\n\n* Minor patients\n* Patients transitioning from one method of extrarenal purification to another\n* Patients requiring urgent dialysis\n* Patients who cannot read or understand French\n* Patients under legal protection (guardianship, curatorship, judicial protection)",{"count":202,"type":23},500,"Background Compared to in-center dialysis, home dialysis is associated with better quality of life and lower healthcare system costs. However, barriers remain to its wider adoption. Chronic disease, particularly at an advanced stage, is a major driver of socioeconomic vulnerability. Among dialysis patients, the proportion of individuals covered by France's Universal Health Protection scheme (PUMA) is higher than in the general population. Similarly, those from the most disadvantaged social classes are overrepresented among dialysis patients compared to the overall French population. Dialysis can also lead to job loss. Financial compensation schemes may influence the choice of home dialysis. In France, patients who perform dialysis at home-either independently or with help from a trained family caregiver-are eligible for a \"third-person compensatory allowance\" (DTP). For some socioeconomically vulnerable patients, eligibility for DTP may influence their decision to opt for home treatment. The DTP is specific to the French healthcare system but could be considered in other countries, particularly within the European Union. Indeed, in most countries with income levels comparable to France, the additional cost of home dialysis is borne by the patient. This study aims to determine whether receiving financial compensation plays a role in choosing a dialysis modality (home-based versus in-center or assisted home dialysis).\n\nObjectives To investigate factors associated with patient preferences regarding renal replacement therapy.\n\nMethods A discrete choice experiment (DCE) was conducted comparing two options: home dialysis (PD and HHD, with DTP) versus in-center hemodialysis (no DTP).\n\nPerspectives If financial compensation influences patients' choices toward home dialysis, the DTP model could be used to address barriers to home-based treatment.",[205],"End Stage Chronic Renal Failure",[207,208,209,210],"Nephrology","Home Dialysis","Chronic Kidney Disease","Discrete Choice Experiment","2026-04-09",{"date":213,"type":40},"2026-04-17",{"date":215,"type":40},"2025-12-16",{"date":217,"type":23},"2027-12-31",{"name":46,"class":47},2,{"id":221,"slug":222,"hasResults":12,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":226,"eligibilityCriteria":227,"healthyVolunteers":228,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":24,"phases":231,"briefSummary":232,"conditions":233,"keywords":238,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":48},"100330747","neuropsychological-and-brain-medical-imaging-study-in-patients-with-brain-damage-2-100330747","NCT03586258","Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2","Anatomical Clinical Correlations. Neuropsychological and Brain Medical Imaging Study in Brain Damage Subjects 2 (CORAC2)","CORAC2","Inclusion Criteria:\n\n* Age \\> 17 years\n* French language\n* Effective contraception for women during the study\n* Informed consent\n* No alcohol intake the day before the exam\n* For patients only, focal cerebral lesion (stroke, malformation, tumor, inflammatory, infectious, traumatic), neonatal pathology, developmental or degenerative disease with cognitive deficit\n\nExclusion Criteria:\n\n* For healthy volunteers: previous neurological history (except non complicated migraine or epilepsy), previous psychiatric history (except depression with good evolution or anxiety), or severe cranial traumatism\n* For patients: vigilance disorders, severe depression or anxiety.\n* For both: psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month, severe visual or auditory impairment, patient without judicial or administrative liberty, measure of legal protection or no capable to express their consent, pregnancy or breastfeeding, contraindication for MRI or GVS if applicable, participation in another trial or former involvement in another trial within one month.",true,{"count":230,"type":23},400,[26],"Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative\u002Fdevelopmental disorders and selective cognitive disorders; (ii) healthy control subjects.\n\nThe objective of this project is to evaluate specific neuropsychological deficits and apply current brain imaging techniques (anatomical, diffusion, functional, magnetic stimulation) to patients suffering from these cognitive deficits due to brain damage, in order to elucidate the brain mechanisms underlying these deficits.",[234,235,236,237],"Cerebrovascular Disorders","Brain Lesion","Degenerative Disease","Developmental Disability",[239,240],"Neuropsychological study","Brain imaging",{"date":242,"type":40},"2026-04-13",{"date":244,"type":40},"2019-01-10",{"date":246,"type":23},"2030-06",{"name":46,"class":47},{"id":249,"slug":250,"hasResults":12,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":12,"sex":18,"minAge":100,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":24,"phases":259,"briefSummary":260,"conditions":261,"keywords":263,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":48},"100632968","phase-3-effectiveness-of-early-information-and-endorsment-by-gp-to-increase-colonoscopy-follow-up-and-reduce-delays-in-people-with-a-positive-colorectal-cancer-screening-test-suivicolo-100632968","NCT07520578","EFFECTIVENESS OF EARLY INFORMATION AND ENDORSMENT BY GP TO INCREASE COLONOSCOPY FOLLOW-UP AND REDUCE DELAYS IN PEOPLE WITH A POSITIVE COLORECTAL CANCER SCREENING TEST. (SUIVICOLO)","EFFECTIVENESS OF EARLY INFORMATION AND ENDORSMENT BY GP TO INCREASE COLONOSCOPY FOLLOW-UP AND REDUCE DELAYS IN PEOPLE WITH A POSITIVE COLORECTAL CANCER SCREENING TEST, A RANDOMISED CONTROLLED TRIAL. (SUIVICOLO)","SUIVICOLO","Inclusion Criteria:\n\n* Aged between 50 and 75 at the time of the positive colorectal cancer screening test\n\n  * Residing in one of the departments of the Centre Val de Loire region\n  * Date on which the positive CRC screening test result was sent to the beneficiary recorded\n  * Colorectal cancer screening test results sent to the beneficiary within 30 days of the test being read\n  * Affiliated with a health insurance fund\n\nExclusion Criteria:\n\n* Subjects who have notified their refusal to allow their data to be used for research purposes will be excluded from the analyses.","75 Years",{"count":258,"type":23},2000,[104],"To be effective, organized colorectal cancer screening requires good adherence to diagnostic colonoscopy in the event of a positive test. In France, the rate of diagnostic colonoscopy following a positive colorectal cancer screening test is less than 85%, and the median delay is close to 90 days. After receiving their positive result from the laboratory, individuals with no known follow-up are contacted only six months later by the Regional Cancer Screening Coordination Centers (CRCDC) responsible for following up with individuals who have tested positive. To optimize follow-up with colonoscopy, earlier contact and information about colonoscopy appear to be necessary. The contribution of the general practitioner identified on the test could be an additional lever.\n\nThe SUIVICOLO study aims to evaluate the effectiveness on the rate of colonoscopies performed at 6 months of two strategies for optimizing the follow-up of positive results in comparison with control group C (current procedures of the CRCDC Centre Val de Loire without early letter).\n\nThe two strategies evaluated will be:\n\n* Group B1: Sending an early letter signed by the CRCDC accompanied by information leaflet about colonoscopy\n* Group B2: Sending an early letter co-signed by the CRCDC and the general practitioner (identified or provided by the patient on the test identification form) accompanied by information leaflet about colonoscopy.\n\nThese strategies will be compared to the current follow-up strategy in a three arm randomized controlled arm.",[262],"Colorectal Cancer Screening",[264,265],"Colonoscopy","Fecal immunochemical test","2026-04-02",{"date":211,"type":40},{"date":269,"type":23},"2026-03-24",{"date":271,"type":23},"2028-10-24",{"name":46,"class":47},{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":228,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":178,"phases":4,"briefSummary":282,"conditions":283,"keywords":286,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":48},"100619160","evaluation-of-a-neuropsychological-tool-to-assess-temporal-processing-abilities-in-alzheimers-disease-100619160","NCT07341009","Evaluation of a Neuropsychological Tool to Assess Temporal Processing Abilities in Alzheimer's Disease","CHRONOS","Inclusion Criteria:\n\n* No objection from the participant or their legal representative, if applicable, prior to or during the assessment\n* Deficit in at least two cognitive functions, including episodic memory.\n\nExclusion Criteria:\n\n* History of head trauma with loss of consciousness lasting more than 1 hour\n* Presence of clinically significant major psychiatric disorders (according to DSM-IV-TR criteria)\n* Use of medications likely to alter cognitive and\u002For brain function (decision by the principal investigator)",{"count":281,"type":23},40,"Perceiving and representing the passage of time allows us to temporally organize perceptions and memories for the coordination of actions, planning, and the mobilization of cognitive processes toward a goal. This innovative project aims to clarify the profile of time impairment associated with normal aging and the progression of age-related pathologies. This project proposes to develop a new neuropsychological tool for quantifying and preventing changes in the relationship to time associated with Alzheimer's disease. Four aspects of time are distinguished, which are measured separately and distributed along a continuum between perception and memory: (a) perception of simultaneity and order; (b) processing of durations; (c) subjective sense of the passage of time; and (d) mental time travel. Crucially, many neurological and psychiatric disorders are associated with impairment in one or more aspects of time. However, time remains largely unexplored in clinical practice. Patients with Alzheimer's disease will complete the CHRONOS battery. This battery allows for a rapid assessment (approximately ten minutes) of the four aspects of time. This new battery will enable the identification of behavioral markers aimed at improving prognosis and prevention regarding individual cognitive trajectories of aging. The relationship to time is closely linked to each person's personal experience. This project will help to put into words difficulties that are not always expressed in terms of time. Thus, considering these pathologies from the perspective of time aims to better understand and prevent their difficulties and to guide the identification of new markers and new avenues for remediation.",[284,285],"Alzheimer's Disease (AD)","Time Perception",[287,288,289,290],"temporal cognition","dementia","cognition","neuropsychology","2026-03-17",{"date":293,"type":40},"2026-03-19",{"date":295,"type":40},"2025-12-30",{"date":297,"type":23},"2027-11-01",{"name":46,"class":47},{"id":300,"slug":301,"hasResults":12,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":305,"eligibilityCriteria":306,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":307,"targetDuration":309,"studyType":178,"phases":4,"briefSummary":310,"conditions":311,"keywords":315,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":321,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":48},"100607682","ml-score-prediction-of-cardiotoxicity-in-cancer-patients-receiving-anthracycline-chemotherapy-or-her2-targeted-therapies-100607682","NCT07191730","ML Score Prediction of Cardiotoxicity in Cancer Patients Receiving Anthracycline Chemotherapy or HER2-Targeted Therapies","Machine Learning Score Prediction of Cardiotoxicity in Cancer Patients Receiving Anthracycline Chemotherapy or HER-2-Targeted Therapies","ML-CardioTox","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Planned follow-up in cardio-oncology clinic as part of a baseline pre-treatment evaluation before a sequence of anthracycline and\u002For HER2-targeted therapy, according to the 2022 ESC recommendations\n* Inclusion regardless of prior exposure to potentially cardiotoxic anticancer therapies or thoracic radiotherapy\n\nExclusion Criteria:\n\n* Patients not covered by the French national health insurance system (Sécurité Sociale)\n* Patients for whom 12-month follow-up is planned outside the center performing the baseline pre-treatment evaluation",{"count":308,"type":23},600,"12 Months","Cancer treatments have improved substantially over the past decades, but some effective therapies such as anthracyclines and HER2-targeted agents are associated with severe cardiovascular adverse effects, including heart failure. Existing cardiovascular risk prediction scores have limited evidence in this setting.\n\nThe ML-CardioTox study is a prospective, multicenter, observational cohort conducted in 15 centers in France. The primary objective is to develop a one-year prediction score for cancer therapy-related cardiotoxicity using machine learning methods. A dedicated software platform will be used to standardize data collection and support integration of artificial intelligence tools.\n\nA total of 600 patients treated with anthracyclines or HER2-targeted therapies in cardio-oncology clinics will be enrolled over a one-year inclusion period starting in December 2024, with a 12-month follow-up. The primary endpoint is the occurrence of cardiotoxicity as defined by the 2022 European Society of Cardiology guidelines (hospitalization for heart failure, initiation or escalation of diuretic therapy, decline in cardiac function on imaging, or increase in cardiac biomarkers such as troponin or natriuretic peptides).\n\nSecondary objectives include comparison of the predictive performance of the machine learning-derived score with the established HFA-ICOS risk score. Patients will be managed according to routine clinical practice.\n\nThis study aims to improve prognostic stratification tools for patients receiving anthracyclines or HER2-targeted therapies, with the goal of better identifying those at high risk of developing cardiotoxicity during follow-up.",[312,29,313,314],"Cardiotoxicity","Neoplasms","Breast Neoplasms",[316,317,318,319,320],"Cancer Therapy-Related Cardiac Dysfunction","Anthracyclines","HER2-targeted Therapy","Cardio-Oncology","Machine Learning",{"date":293,"type":40},{"date":323,"type":40},"2025-10-29",{"date":325,"type":23},"2028-11",{"name":46,"class":47},{"id":328,"slug":329,"hasResults":12,"nctId":330,"briefTitle":331,"officialTitle":332,"acronym":333,"eligibilityCriteria":334,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":335,"targetDuration":337,"studyType":178,"phases":4,"briefSummary":338,"conditions":339,"keywords":4,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":4},"100565251","respiratory-microbioma-and-respiratory-complications-after-hematopoietic-stem-cell-transplantion-100565251","NCT06639750","Respiratory Microbioma and Respiratory Complications After Hematopoietic Stem Cell Transplantion","Dynamic Evaluation of Composition and Evolution of Respiratory Viroma\u002FMicrobioma of Patients Who Have Undergone Hematopoiteic Stem Cell Transplantation (HSCT), as a Possible Biomarker of Occurrence of Post-HSCT Pulmonary Complications.","VIREMIG","Inclusion Criteria:\n\n* Male or female, aged 18 or over\n* French-speaking\n* Followed in the centre's haematology department with a project for a haematopoietic stem cell allograft\n* Whatever the haemopathy, previous treatments, type of transplant (pheno, geno, haplo-identical), type of graft (bone marrow, peripheral stem cells, cord blood), any conditioning (myeloablative or non-myeloablative), any immunosuppressive protocol.\n* Be affiliated to the social security system\n* Person able to understand the information and sign the consent form.\n* Informed consent must be collected and signed\n\nExclusion Criteria:\n\n* Refusal to take part in the research\n* Failure to sign the consent form\n* Contraindication to nasopharyngeal swabbing",{"count":336,"type":23},120,"2 Years","Allogeneic haematopoietic stem cell transplantation (AHSCT) is a therapeutic resource for many haemopathies. The number of HSCTs has risen sharply in recent years due to the use of attenuated conditioning, which has increased the risk of non-haematological complications. Pulmonary pathologies are a frequent cause of complications following HSCA, both infectious and non-infectious(1,3,4).\n\nAmong these, late non-infectious pulmonary complications (LNIPC), all taken together, occur in 25% of post-HSCA cases(1). These NIPCs, the most common of which is bronchiolitis obliterans, significantly alter the prognosis(4,5). The pathophysiology of CPTNI is poorly understood, but it seems that the occurrence of a viral respiratory infection (pre- or post-ACSH) may be a potential trigger for the onset of CPTNI(1). These viral infections can become \"chronic\", given that viral clearance is impaired by the underlying immunodepression, and can thus cause chronic inflammation leading to the fibrosing and irreversible process of obliterative bronchiolitis(6). Given the prognostic importance of this type of CPTNI, it seems essential to gain a better understanding of its pathophysiology, which may involve a number of mechanisms: cellular expression of the graft and its evolution, disruption of the host response (innate immunity) following viral infection, influence of the microbiome and alteration of epithelial repair(1,3,5). Interest in the digestive and respiratory microbiome has been growing in recent years(7-9). The literature is gradually being enriched with data on the links between infection, the microbiome and chronic respiratory pathology and, in the post-HSCA context, a potential link between the enteric microbiome and Chronic Graft Versus Host Disease (cGVHD).\n\nA pilot study comparing respiratory microbiomes using sequencing and metatranscriptomic analysis on 20 respiratory samples (nasopharyngeal swab and bronchoalveolar lavage pairs) taken under the conditions of the proposed study showed that the technique was highly feasible and highly sensitive.\n\nThe aim of this study is therefore to use meta-genomics to investigate the respiratory virome\u002Fmicrobiome in a population of patients who have undergone HSCA: eukaryotic and prokaryotic viruses, bacterial expression and the expression (meta-transcriptomics) of graft-derived cell lines and their possible association with the occurrence of post-HSCA respiratory complications (infectious and non-infectious).\n\nNo study has assessed the link between the composition of the respiratory virome\u002Fmicrobiome and the occurrence of respiratory events (infectious and CPTNI post ACSH), but also more broadly the link with the composition of the microbiome in the broad sense (respiratory virome, respiratory and digestive microbiota).\n\nThe aim of this study is to establish a respiratory viral and bacterial map as a possible biomarker of the occurrence of respiratory events (infectious and CPTNI), thus enabling more personalised monitoring of patients at risk of CPTNI and management of immunosuppressive treatment of patients at risk of an infectious episode, with risk assessment based on the composition of the respiratory virome.\n\nThe interest of this study is that it is multidisciplinary and transdisciplinary, studying the respiratory pathologies and infections of haematology patients and combining clinical and fundamental research, with expected spin-offs for direct patient care (personalised monitoring and management of immunosuppressive treatments).",[340,341,342],"Hematopoietic Stem Cell Transplantation","Microbioata","Respiratory Complications",{"date":344,"type":40},"2026-03-18",{"date":346,"type":23},"2026-04-01",{"date":348,"type":23},"2030-04-01",{"name":46,"class":47},{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":356,"eligibilityCriteria":357,"healthyVolunteers":12,"sex":18,"minAge":78,"maxAge":358,"enrollmentInfo":359,"targetDuration":4,"studyType":24,"phases":361,"briefSummary":363,"conditions":364,"keywords":366,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":48},"100629627","phase-4-a-dose-response-study-to-determine-the-right-dosage-of-sugammadex-as-a-reversal-agent-of-rocuronium-in-infants-between-1-and-24-months-old-100629627","NCT07477132","A Dose-response Study to Determine the Right Dosage of Sugammadex as a Reversal Agent of Rocuronium in Infants Between 1 and 24 Months Old","Study to Determine the Dosage of Sugammadex as a Rocuronium Reversal's Agent in Infants Younger Than 24 Months Old","SUGAPEDIA","Inclusion Criteria:\n\n* Child, male or female, aged \\\u003C 24 months.\n* American Society of Anesthesiologists (ASA) Physical Status Class I or II.\n* Non-cardiac and non-emergency surgical procedure, or relative emergency (\\>12 h) requiring neuromuscular blockade with rocuronium and reversal with sugammadex.\n* Surgical procedure allowing neuromuscular monitoring at the adductor pollicis muscle.\n* Child covered by a social security regiment.\n* Written informed consent signed by the holder(s) of parental authority.\n* French-speaking holder(s) of parental authority.\n\nExclusion Criteria:\n\n* Child who received or will receive toremifene or fusidic acid within 24 hours before or after administration of the study treatments (rocuronium, sugammadex).\n* Use of two different neuromuscular blocking agents during the procedure.\n* Failure to calibrate the Train-of-Four (TOF) qualitative count (TOFc) and quantitative ratio (TOFr).\n* Non-compliance with the titrated administration protocol of sugammadex and TOF monitoring during the study.\n* Use, during the procedure, of medications that may interfere with the study treatments: aminoglycosides, lincosamides, polymyxins, quinidine, quinine, magnesium salts, phenytoin, carbamazepine, or continuous IV lidocaine.\n\nNon inclusions criteria :\n\n* Emergency requiring care in the operating room within \\\u003C 12 hours.\n* Child weighing more than 20 kg.\n* Premature child: \\\u003C 37 weeks gestational age at birth.\n* Suspected or diagnosed neuromuscular disorder at the time of surgical care.\n* Child suspected of having,or with a family history of, malignant hyperthermia.\n* Child suspected of having, or with a known allergy to, the medications used in the study (rocuronium, sugammadex) or any of their respective excipients.\n* Child expected to require mechanical ventilation at the end of the surgical procedure.\n* Child receiving, at the time of inclusion, regular treatment with medications that may interfere with the treatments used in this study: aminoglycosides, lincosamides, polymyxins, quinidine, quinine, magnesium salts, phenytoin, carbamazepine.\n* Minor holders of parental authority, or children under guardianship or curatorship.","24 Months",{"count":360,"type":23},99,[362],"PHASE4","Sugammadex is a drug used more and more frequently in infants as a rocuronium' s reversal agent. It has multiples benefits over other reversal agents such as a rapid onset of action and a complete reversal no matter how deep is the neuromuscular blockade.\n\nThe dosage of sugammadex used in current clinical practice is the same as in adults based on empirical evidence. Futhermore some multricentric studies showed that that dosage might not be appropriate for infants younger than 2 years old.\n\nThe goal of this study is to determine the correct dosage of sugammadex to use in infants younger than 2 years old.",[365],"Curarization, Postoperative Residual",[367,368,369],"Neuromuscular blocking agent","children","curarization","2026-03-13",{"date":291,"type":40},{"date":373,"type":23},"2026-03-30",{"date":375,"type":23},"2027-10-01",{"name":46,"class":47},{"id":378,"slug":379,"hasResults":12,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":384,"targetDuration":386,"studyType":178,"phases":4,"briefSummary":387,"conditions":388,"keywords":4,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":394,"leadSponsor":396,"locationsCount":48},"100628852","bachstim-registry-a-feasability-study-of-bachmanns-area-pacing-100628852","NCT07467031","Bachstim Registry: a Feasability Study of Bachmann's Area Pacing","BACHSTIM REGISTRY: a Feasability Prospective Study of Bachmann's Area Pacing","Inclusion Criteria:\n\n* Cardiac pacemaker with atrial lead indication\n\nExclusion Criteria:\n\n* patients \\\u003C 18 years old\n* pregnancy of breast feeding",{"count":385,"type":23},200,"1 Year","During pacemaker implantation, the atrial lead is commonly positioned in the right atrium. However, this pacing location can be problematic because it may disrupt physiological atrial activation, leading to atrial dyssynchrony. Such dyssynchrony has been associated with an increased risk of atrial fibrillation and its related complications.\n\nTo mitigate atrial dyssynchrony, pacing of the Bachmann's bundle region has emerged as an alternative strategy. Bachmann's bundle is the principal interatrial conduction pathway, and pacing at this site may help preserve physiological atrial activation. Several studies have suggested that pacing in this region can significantly reduce the incidence of new-onset atrial fibrillation and heart failure in selected populations.\n\nTo date, however, robust data from large cohorts regarding the feasibility of Bachmann's bundle area pacing and the factors associated with successful implantation remain limited. To address this gap, we established the Bachstim cohort study, aimed at determining the success rate of Bachmann's bundle area pacing and identifying the clinical and procedural factors associated with its feasibility.",[389],"Cardiac Conduction Disturbance","2026-03-09",{"date":392,"type":40},"2026-03-12",{"date":346,"type":23},{"date":395,"type":23},"2028-04-01",{"name":46,"class":47},{"id":398,"slug":399,"hasResults":12,"nctId":400,"briefTitle":401,"officialTitle":402,"acronym":403,"eligibilityCriteria":404,"healthyVolunteers":12,"sex":18,"minAge":405,"maxAge":406,"enrollmentInfo":407,"targetDuration":4,"studyType":24,"phases":409,"briefSummary":410,"conditions":411,"keywords":4,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":420,"startDateStruct":422,"completionDateStruct":424,"leadSponsor":426,"locationsCount":4},"100625797","focused-echocardiography-for-primary-care-physicians-100625797","NCT07427303","Focused Echocardiography for Primary Care Physicians","CLINICAL FEASIBILITY OF ULTRAPORTABLE CARDIAC ULTRASOUND PERFORMED IN THE GENERAL PRACTITIONER'S OFFICE TO IDENTIFY CARDIOVASCULAR ABNORMALITIES","UPCOMING","Inclusion Criteria:\n\n* Men and women aged 65 or older with no cardiac symptoms and presenting with a treated or untreated cardiovascular risk factor (hypertension and\u002For diabetes and\u002For dyslipidemia) or\n* Adult men and women presenting with one of the following signs:\n\n  * Stage I-II exertional dyspnea\n  * Lower limb edema\n  * Unexplained fatigue\n  * Weight gain\n  * Unexplained cough\n  * History of carpal tunnel surgery (search for signs of myocardial infiltration by cardiac amyloidosis)\n\nExclusion Criteria:\n\n* Patients with arrhythmia or ventricular or supraventricular hyper excitability.\n* Symptomatic patients:\n\n  * exertional dyspnea (NYHA \\>2)\n  * palpitations\n  * malaise\n  * chest pain\n* Obese individuals with a BMI \\>35\n* Patients with breast implants\n* Patients under guardianship, conservatorship, or legal protection\n* Patients without health insurance coverage or equivalent\n* Patients known to have heart disease\n* Patients who have had a cardiology consultation within the last 5 years\n* Subjects with known heart disease, whether monitored or not.\n* Known valvular heart disease (whether monitored or not)\n* Known coronary artery disease (whether monitored or not)","65 Years","120 Years",{"count":408,"type":23},300,[26],"Our society is characterized by a steady improvement in the standard of living of its inhabitants, which is reflected, among other things, in improved healthcare and quality of life (longer life expectancy, lower infant mortality, treatment of chronic diseases, cancer plan). Many factors contribute to this, but technological innovations and therapeutic advances are the main ones. This positive overall picture should not obscure the fact that there are significant regional disparities.\n\nFor more than 15 years, the former Lower Normandy region (Calvados, Manche, and Orne), like many other regions in France, has been marked by increasingly complex access to healthcare, whether for primary care or for so-called specialty disciplines. This situation is gradually leading to the creation of medical deserts. There are many reasons for this (numerus clausus, sociological changes, urbanization of young practitioners, attraction of small rural towns by medium-sized cities), which are chronic and have no clearly identified solution.\n\nThis situation complicates patient care and, in some cases, represents a major public health challenge, such as in the treatment of heart failure (HF), which affects more than one million people in France, or 2.3% of the adult population. For 2.3 times more deaths each year than strokes and five times more than myocardial infarctions.\n\nSome healthcare innovations can reduce the consequences of these areas of stress. In the field of cardiology, recent initiatives based on the creation of specialized cardiology and telemedicine care teams have been proposed. In primary care, point-of-care solutions enable many tests to be performed on an outpatient basis. Imaging plays a central role in patient care, and ultrasound is often the first-line modality in cardiology. Technological innovations in this field have made it possible to miniaturize ultrasound machines to such an extent that some of them can now be considered POCUS (point-of-care ultrasound). Their reduced manufacturing costs, combined with the maturity of the technique, make it possible to offer simplified acquisition protocols adapted to specific questions, known as targeted clinical ultrasound.\n\nThis simplification\u002Fminiaturization of ultrasound equipment has facilitated the spread of this technique outside the field of cardiology and now allows for its use by general practitioners close to patients, specifically for screening purposes. Many diseases would benefit from early screening in order to reduce hospitalizations, mortality, and societal costs. In cardiology, this approach remains difficult because the majority of patients admitted to healthcare facilities have already developed the disease. HF is characterized by an initial silent phase which, if left untreated, inevitably leads to complications and death. It is responsible for 200,000 hospitalizations per year in France, causing the deaths of 70,000 people. Certain signs, grouped under the French acronym EPOF, appear early on and can be warning signs, but they are often vague and unfamiliar to the general public. This fact is well illustrated by the results of a survey conducted by the Heart Failure and Cardiomyopathy Group (GICC) of the French Society of Cardiology (SFC) in 2017 (5,000 subjects representative of the French population aged 18 to 80). This survey noted that two-thirds of subjects presenting four of these signs (EPOF) had not consulted a cardiologist in the 12 months prior to the questionnaire. In the majority of cases, these patients, whether asymptomatic or paucisymptomatic (EPOF), have morphological and functional abnormalities of the heart, which are the first step toward more severe complications and can be detected by cardiac echocardiography.\n\nThere is currently a favorable alignment between echocardiography as a public health need (early detection of conditions that can lead to heart failure) and frontline practitioners (general practitioners). This alignment could lead to the definition of new practices and a new care pathway. While echocardiography is technically feasible in a general practitioner's office, its implementation remains to be evaluated (HAS report). This report emphasizes the lack of data in the literature to identify use cases and clinical impact in general medicine in France.",[412,413,414,415,416,417,418],"Age 65 and Older","Cardiac Risk Factors","Dyspnea; Cardiac","Oedema","Fatigability","Cough","Weight Gain","2026-02-16",{"date":421,"type":40},"2026-02-23",{"date":423,"type":23},"2026-03-01",{"date":425,"type":23},"2027-05-31",{"name":46,"class":47},{"id":428,"slug":429,"hasResults":12,"nctId":430,"briefTitle":431,"officialTitle":431,"acronym":432,"eligibilityCriteria":433,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":434,"enrollmentInfo":435,"targetDuration":4,"studyType":24,"phases":437,"briefSummary":438,"conditions":439,"keywords":445,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":465},"100624563","premabiom-metatranscriptomics-of-the-respiratory-microbiome-to-predict-the-occurrence-of-bronchopulmonary-dysplasia-in-preterm-infants-100624563","NCT07411261","PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants","PremaBiom","Inclusion Criteria:\n\n* Preterm infants with gestational age at birth lower than 32 gestational weeks and 6 days.\n* Hospital stay in one of the participant neonatal care units\n* Infants covered by the social security system of at least one of their parents\n* Whose parents have been informed about the study and agree to sign the informed consent form\n\nExclusion Criteria:\n\n* Palliative care only\n* Lack of parental consent\n* Parents who are minors or under legal protection (guardianship, conservatorship, judicial protection)\n* Parents who do not speak French","72 Hours",{"count":436,"type":23},270,[26],"The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks. The main questions it aims to answer are:\n\n* What is the role of microbiome maturation in respiratory health (development of bronchopulmonary dysplasia, childhood asthma and viral respiratory infections) of preterm infants ?\n* Which environmental or health factors are involved in the maturation of the respiratory microbiome ?\n\nParticipants will undergo follow-up from birth until 3 years of corrected age including nasal swabs, stool samples, and for some of them blood and milk sample.",[440,441,442,443,444],"Bronchopulmonary Dysplasia","Preterm Infant Development","Asthma Childhood","Bronchiolitis","Viral Respiratory Tract Infections",[446,447,448,449,450,451,452,453,454,455,456],"respiratory microbiome","bronchopulmonary dysplasia","Prematurity","asthma","bronchiolitis","inflammation","inate immunity","respiratory tract infections","dysbiosis","personalized medicine","metatranscriptomics","2026-02-11",{"date":459,"type":40},"2026-02-13",{"date":461,"type":23},"2026-03",{"date":463,"type":23},"2031-03",{"name":46,"class":47},6,{"id":467,"slug":468,"hasResults":12,"nctId":469,"briefTitle":470,"officialTitle":470,"acronym":471,"eligibilityCriteria":472,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":473,"targetDuration":309,"studyType":178,"phases":4,"briefSummary":474,"conditions":475,"keywords":4,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":48},"100624215","feasibility-and-outcomes-registry-of-lumenless-defibrillation-leads-for-conduction-system-pacing-100624215","NCT07406737","Feasibility and Outcomes Registry of Lumenless dEfibrillation Leads for Conduction System Pacing","FORGE CSP","Inclusion Criteria:\n\n* age \\> 18-year-old\n* indication for CRT according to current ESC\u002FEHRA guidelines\n* first-line LBBAP ICD lead implantation attempted\n* national insurance coverage\n\nExclusion Criteria:\n\n* pregnancy",{"count":385,"type":23},"The recent development and market introduction of small diameter implantable defibrillation leads able to deliver left bundle branch area pacing (LBBAP) has opened the possibility of achieving cardiac resynchronization therapy (CRT) using a single- or dual-chamber implantable-cardioverter defibrillator (ICD). This approach may reduce the number of intracardiac leads required and, consequently, has the potential to lower both procedural and long-term complication rates. However, the integration of these leads into currently recommended CRT strategies remains hypothetical. The FORGE CSP registry will prospectively enroll patients with an indication for CRT in whom implantation of a LBBAP ICD lead is attempted.",[476,477],"Cardiac Resynchronization Therapy","Left Bundle Branch Area Pacing","2026-02-06",{"date":480,"type":40},"2026-02-12",{"date":482,"type":23},"2026-05-01",{"date":484,"type":23},"2027-09-01",{"name":46,"class":47},{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":492,"eligibilityCriteria":493,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":494,"targetDuration":4,"studyType":178,"phases":4,"briefSummary":495,"conditions":496,"keywords":498,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":511,"locationsCount":4},"100621590","influence-of-therapeutic-failure-on-the-psychosocial-experience-in-multiple-sclerosis-100621590","NCT07372599","Influence of Therapeutic Failure on the Psychosocial Experience in Multiple Sclerosis","Influence of Therapeutic Failure on the Psychosocial Experience of Patients With Relapsing-remitting Multiple Sclerosis","INPSYSEP","Inclusion Criteria:\n\n* Patient aged 18 or over.\n* Patient with RRMS according to McDonald 2024 criteria.\n* Uninterrupted use of a moderately effective treatment, or highly effective treatment only if it is the first DMT, for at least 6 months.\n* Collection of non-objection.\n* Patient affiliated to the social security system.\n\nExclusion Criteria:\n\n* Patient with progressive MS.\n* Patient treated continuously with the same DMT for 3 years or more.\n* Patient who received a second line DMT or an immunosuppressant before taking a first line DMT.\n* Patients who have received mitoxantrone as the first treatment\n* Pregnant or breast-feeding woman at the time of inclusion.\n* Severe cognitive and\u002For psychological disorders which, according to the investigator (with or without a neuropsychological assessment), prevent the participant from completing the self-questionnaires independently and accurately.",{"count":102,"type":23},"Multiple sclerosis (MS), an inflammatory, neurodegenerative disease of the central nervous system, affects around 120,000 patients in France and is the leading cause of non-traumatic disability in young adults. It affects patients' health-related quality of life (QoL) and has a significant economic impact on patients and society as a whole. Early initiation of disease-modifying therapy (DMT) is recommended in relapsing-remitting MS (RRMS). Nevertheless, according to a recent French cohort, 30% of patients initially treated with a first-line FT will switch to a highly effective compound within 5 years due to its ineffectiveness. Therapeutic failure (Th-F) is therefore a frequent occurrence, but its psychological, social and economic consequences are poorly understood. These elements are generally the subject of measurements reported by patients, and several studies have highlighted the importance of taking them into account in the management of these patients.\n\nHere, the investigators will study two categories of these measures in a Th-F situation. On the one hand, patient-reported outcome measurements (PROMs) will be examined. Patients' psychological distress and their QoL are two important examples of psychosocial impacts in patients with MS, compared to the general population. The impact on activity levels is also well known, but the specific effect of Th-F has not yet been studied. On the other hand, patients' experiences of their care pathway and their opinion on the quality of care (patient-reported experience measurement \\[PREM\\]) will also be studied. Some PREMs refer to care coordination, satisfaction with the relationship with carers or doctors' empathy levels. To date, data on the experience of MS patients regarding their care pathway remains limited and non-existent during Th-F.\n\nFinally, the influence of socioeconomic status (SES) on PROMs and PREMs is worth considering. In the general population, patients' experience of care can be influenced by their socioeconomic status. Compared with research on other diseases (notably cardiovascular diseases and cancers), there is relatively little work on the association between socioeconomic status and MS and none has focused on the topic of Th-F.\n\nThe investigators therefore hypothesise that a quality of care perceived favourably by MS patients may moderate the negative impact of Th-F on their QoL, anxiety\u002Fdepression and activity levels (as recently described in oncology), and a more recent measure of abilities assessing well-being defined in a broad sense, as a function of their SES.",[497],"Multiple Sclerosis",[499,500,501,502,503,504],"Patient-reported-outcome","Patient-reported-experience","Quality of life","Socioeconomic status","Therapeutic failure","Multiple sclerosis","2026-02-04",{"date":478,"type":40},{"date":508,"type":23},"2026-02-01",{"date":510,"type":23},"2029-08-01",{"name":46,"class":47},{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":517,"acronym":518,"eligibilityCriteria":519,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":24,"phases":522,"briefSummary":523,"conditions":524,"keywords":4,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":528,"startDateStruct":530,"completionDateStruct":531,"leadSponsor":533,"locationsCount":48},"100620467","double-blind-randomized-non-inferiority-trial-in-atopic-dermatitis-comparison-of-lipikar-balm-and-relipid-balm-in-the-treatment-of-mild-to-moderate-atopic-dermatitis-in-children-and-adults-100620467","NCT07358000","Double-blind, Randomized, Non-inferiority Trial in Atopic Dermatitis: Comparison of Lipikar Balm and Relipid+ Balm in the Treatment of Mild to Moderate Atopic Dermatitis in Children and Adults","AIMSI Trial : Double-blind, Randomized, Non-inferiority Trial in Atopic Dermatitis: Comparison of Lipikar Balm and Relipid+ Balm in the Treatment of Mild to Moderate Atopic Dermatitis in Children and Adults","AIMSI","Inclusion Criteria:\n\nPatients aged 6 months to 70 years with mild to moderate atopic dermatitis (SCORAD \\\u003C 40)\n\nTime to treatment initiation \\\u003C 72 hours between initial assessment and balm application\n\nAffiliated with the French national health insurance system and French-speaking\n\nWritten informed consent must be obtained\n\nExclusion Criteria:\n\nPatients who decline participation\n\nPatients under legal guardianship, curatorship, legal protection, or judicial safeguard\n\nPatients with a SCORAD indicating the need for systemic therapy",{"count":521,"type":23},86,[26],"The therapeutic cornerstone for mild to moderate forms of atopic dermatitis (AD) relies on the combination of topical corticosteroids and emollients. However, the daily application of emollients can be burdensome, leading to poor adherence, treatment fatigue, and therapeutic failure, often prompting a switch in emollient products.\n\nEmollients therefore represent a true therapeutic challenge. They also raise economic concerns, as they are not reimbursed by national health insurance, unlike topical corticosteroids. This results in an out-of-pocket expense for patients, adding a significant financial burden in the context of this chronic skin condition.\n\nLaboratoires Gilbert have developed and patented an active ingredient derived from seawater (Active Oligo Skin), formulated and produced at their pharmaceutical site in Hérouville Saint Clair. This active compound has shown promising in vitro and preclinical results in modulating inflammatory mechanisms involved in sensitive and atopic skin.\n\nThe objective of this clinical trial is to compare the efficacy of Laboratoires Gilbert's patented emollient balm (Relipid+) with a reference emollient balm considered the \"gold standard\" and most frequently prescribed on the market (Lipikar Baume AP+M, La Roche-Posay) for atopic dermatitis. The hypothesis is that the test balm will be at least as effective as the gold standard (non-inferiority) in clinical terms, with an added benefit on microbiome diversity-an emerging and critical issue in the management of atopic dermatitis.",[525,526],"Atopic Dermatitis","Emollients","2026-01-20",{"date":529,"type":40},"2026-01-22",{"date":373,"type":23},{"date":532,"type":23},"2026-12",{"name":46,"class":47},{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":539,"acronym":540,"eligibilityCriteria":541,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":542,"targetDuration":4,"studyType":24,"phases":544,"briefSummary":545,"conditions":546,"keywords":558,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":561,"lastUpdatePostDateStruct":562,"startDateStruct":563,"completionDateStruct":565,"leadSponsor":567,"locationsCount":48},"100620566","impact-of-a-multimodal-intervention-on-antibiotic-prescribing-for-respiratory-infections-in-primary-care-100620566","NCT07359287","Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care","Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care: A Cluster-Randomized Trial","GRASP","Inclusion Criteria:\n\n\\- Patient seen in consultation for an upper or lower respiratory tract infection (Angina, Acute bronchiolitis, Acute bronchitis, COPD exacerbation (AECOPD), Laryngitis, Acute otitis media (AOM), Serous or congestive otitis, Viral respiratory infection (e.g., influenza), Community-acquired pneumonia (CAP), Rhinitis \u002F Nasopharyngitis, Acute sinusitis)\n\nExclusion Criteria:\n\n\\- Patient under legal protection",{"count":543,"type":23},4500,[26],"Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France are prescribed and where misuse remains common.\n\nWe are proposing a cluster-randomized controlled trial to evaluate the effectiveness of a bimodal intervention combining: (1) improved communication about the circulation of respiratory viruses, and (2) strengthened collaborative practices between general practitioners and pharmacists through a multidisciplinary protocol aimed at verifying that prescribed treatment durations comply with guidelines.\n\nThe study will include six primary care practices (24 physicians), with three practices in each study arm.\n\nThe aim of this project is to assess whether the bimodal intervention can reduce the duration of antibiotic treatments for upper and lower respiratory tract infections. The first component (a \"viral infection prescription\" tool) focuses on reducing unnecessary treatment initiation, while the second (pharmacist-led review) aims to shorten excessive prescription durations.",[547,548,549,550,551,552,553,554,555,556,557],"Angina","Acute Bronchiolitis","Acute Bronchitis","COPD Exacerbation (AECOPD)","Laryngitis","Acute Otitis Media (AOM)","Serous or Congestive Otitis","Viral Respiratory Infection (e.g., Influenza)","Community-Acquired Pneumonia (CAP)","Rhinitis \u002F Nasopharyngitis","Acute Sinusitis",[559,560],"Upper respiratory tract infection","Lower respiratory tract infection","2026-01-13",{"date":529,"type":40},{"date":564,"type":40},"2025-12-01",{"date":566,"type":23},"2026-09-01",{"name":46,"class":47},{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":178,"phases":4,"briefSummary":576,"conditions":577,"keywords":4,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":581,"startDateStruct":582,"completionDateStruct":584,"leadSponsor":586,"locationsCount":4},"100614774","zanubrutinib-and-acalabrutinib-use-and-risk-of-atrial-fibrillation-in-patients-with-chronic-b-cell-malignancies-100614774","NCT07283965","Zanubrutinib and Acalabrutinib Use and Risk of Atrial Fibrillation in Patients With Chronic B-cell Malignancies","Inclusion Criteria:\n\n* adult patients\n* diagnose with chronic B-cell malignancies\n* exposed to zanubrutinib or acalabrutinib\n\nExclusion Criteria:\n\n* none",{"count":575,"type":23},15000,"Background. Zanubrutinib and acalabrutinib are both associated with an increased risk of atrial fibrillation (AF) but AF comparative risk between these 2 BTK inhibitors (BTKis) remains largely unknown.\n\nObjectives. Our aim was to examine the risk of developing incident AF with zanubrutinib exposure compared with acalabrutinib exposure.\n\nMethods. Using the TriNetX research network database, authors will conduct a retrospective cohort analysis of deidentified, aggregate adult patients with chronic B-cell malignancies and exposed to zanubrutinib or acalabrutinib. Patients will be divided into 2 groups based on zanubrutinib or acalabrutinib exposure. After propensity score matching (PSM), Cox proportional hazard models will be used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) to compare the 2 matched groups. The appropriateness of the proportional hazard assumption will be examined and risk differences (RDs) will be used if appropriate. Results will summarized with the use of Kaplan-Meier survival curves.",[578,579,184],"Chronic B-cell Malignancies","BTK Inhibitors","2025-12-12",{"date":215,"type":40},{"date":583,"type":23},"2025-12-22",{"date":585,"type":23},"2026-03-31",{"name":46,"class":47},{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":593,"eligibilityCriteria":594,"healthyVolunteers":228,"sex":18,"minAge":19,"maxAge":150,"enrollmentInfo":595,"targetDuration":4,"studyType":24,"phases":597,"briefSummary":598,"conditions":599,"keywords":602,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":609,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":48},"100550459","alcohol-consumption-norms-identities--motivations-100550459","NCT06447350","Alcohol Consumption: Norms, Identities, & Motivations","Alcohol Consumption: Norms, Identities, & Motivations (ADUC-Volet 3 \" Prevention \")","ALCONIM","Inclusion Criteria:\n\n* aged between 18 and 30 years old,\n* of French mother language,\n* of both sexes,\n* binge drinking score \\> 1,\n* having signed an informed consent.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding students,\n* students who declare a history of neurological, neurosurgical, psychiatric, endocrine or infectious diseases.",{"count":596,"type":23},240,[26],"The emergence of new problematic alcohol consumption practices among young people requires new dynamics in prevention strategies. In this context, the ADUC project (Alcohol and Drugs at the University of Caen) aims to develop a better understanding of alcohol consumption, and in particular the practice of binge drinking (BD), in order to develop relevant and adapted prevention tools. The ALCONIM study (IRESP funding; Agreement 20II31-00 - ADUC part 3) is a randomized controlled trial that focuses on the specific determinants of norms, identities and motivations. The main objective of this experiment in social psychology is to validate a program for the prevention of BD practices based on motivational interviewing (MI) associated with induced hypocrisy (IH), social identity mapping (SIM) and motivational modeling (MM) in a student environment.",[600,601],"Binge Drinking","Alcohol Drinking",[603,604,605,606,607],"norms","induced hypocrisy paradigm","identity","social identity mapping","motivation","2025-11-18",{"date":610,"type":40},"2025-11-21",{"date":612,"type":40},"2024-04-05",{"date":614,"type":23},"2026-06-30",{"name":46,"class":47},{"id":617,"slug":618,"hasResults":12,"nctId":619,"briefTitle":620,"officialTitle":621,"acronym":622,"eligibilityCriteria":623,"healthyVolunteers":12,"sex":624,"minAge":625,"maxAge":19,"enrollmentInfo":626,"targetDuration":4,"studyType":24,"phases":627,"briefSummary":628,"conditions":629,"keywords":634,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":639,"lastUpdatePostDateStruct":640,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":646,"locationsCount":48},"100607698","posthectomy-in-pediatric-elective-surgery--a-comparison-of-perioperative-analgesia-using-echo-guided-penile-block-and-pudendal-block-with-neurostimulation-technique-100607698","NCT07191938","Posthectomy in Pediatric Elective Surgery : a Comparison of Perioperative Analgesia Using Echo-guided Penile Block and Pudendal Block With neurostimuLation Technique","Comparison of Echo-guided Penile Block and Pudendal Block Under Neurostimulation for Perioperative Analgesia of Posthectomy in Pediatric Surgery: a Prospective, Randomized Study at Caen University Hospital","PinEAPPLE","Inclusion Criteria:\n\n* All children aged over 3 months or 60 weeks post-conceptional age scheduled for outpatient posthectomy surgery\n\nExclusion Criteria:\n\n* Recent airway infection.\n* Contraindication to locoregional anesthesia: infection and\u002For loss of substance at the puncture site, congenital or acquired coagulopathy, product allergy.\n* Contraindication to outpatient treatment: age \\\u003C 12 weeks for healthy children or 60 weeks corrected age for premature babies, unbalanced pre-existing pathology (respiratory), ability to understand and comply with instructions (pre-operative fasting, taking painkillers at home and resumption of feeding), inability to ensure the presence of 2 adults including 1 parent on the return journey by car for children \\\u003C 10 years old, easy access to care close to home.\n* Emergency surgery.\n* Coupled surgery (posthectomy + other surgery).\n* Parents' refusal to participate in the study","MALE","12 Weeks",{"count":596,"type":23},[26],"Context : Posthectomy is a surgical procedure that concerns around 30% of the male population, mainly in pediatrics. As this procedure is mainly performed on an outpatient basis, the implementation of an enhanced rehabilitation protocol after surgery in pediatrics helps to reduce the incidence of postoperative pain, notably by providing multimodal analgesia, including locoregional anesthesia. Current recommendations from pediatric locoregional anesthesia societies favor penile block and the use of ultrasound in pediatric anesthesia to reduce anesthetic set-up time and the volume of local anesthetic, but also to increase the duration of sensory block and the success rate. However, several studies have shown the inferiority of penile block in anatomical landmarks compared with pudendal block under neurostimulation. As a result, pediatric anesthesiologists at Caen University Hospital prefer to use pudendal blocks under neurostimulation for posthectomy surgery. To date, no study has compared penile block under ultrasound with pudendal block under neurostimulation for postoperative analgesia after posthectomy surgery. On the other hand, a study of postoperative analgesia in hypospadias surgery showed a clear superiority of penile block under ultrasound over pudendal block in terms of both immediate postoperative pain and duration of postoperative analgesia. It therefore seems pertinent to compare these two techniques in posthectomy surgery.\n\nObjective: We propose a prospective, open-label, non-inferiority study with the primary objective of comparing the efficacy of echo-guided penile block versus pudendal block in neurostimulation for posthectomy surgery.\n\nMethods: This randomized, single-center study will include 240 patients divided into two groups. The experimental group will receive optimized medical and surgical management, with a penile block under ultrasound, while the control group will receive a pudendal block under neurostimulation. The planned duration of the study is 3 years.\n\nHypothesis tested: We hypothesize that ultrasound-guided penile block is non-inferior to neurostimulated pudendal block for postoperative analgesia in scheduled posthectomy surgery. The secondary objectives are to evaluate the time taken to perform the block, the volume of local anesthetic used, the need for sufentanil reinjection intraoperatively, the quantitative evaluation of analgesia using the EVENDOL score, the consumption of nalbuphine in the post anesthesia care unit, the occurrence of postoperative vomiting, and the length of stay in the post anesthesia care unit. The rate of complications related to the performance of locoregional anesthesia is also observed.",[630,631,632,633],"Postoperative Care","Analgesia Assessment","Posthectomy","Postoperative Analgesia",[635,636,637,638],"Neurostimulation guided pudendal block","US guided penile block","Security","Efficiency","2025-09-22",{"date":641,"type":40},"2025-09-25",{"date":643,"type":23},"2025-09",{"date":645,"type":23},"2028-12",{"name":46,"class":47},{"id":648,"slug":649,"hasResults":12,"nctId":650,"briefTitle":651,"officialTitle":651,"acronym":652,"eligibilityCriteria":653,"healthyVolunteers":228,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":654,"targetDuration":4,"studyType":24,"phases":656,"briefSummary":657,"conditions":658,"keywords":661,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":664,"lastUpdatePostDateStruct":665,"startDateStruct":667,"completionDateStruct":668,"leadSponsor":670,"locationsCount":48},"100605209","music-listening-impact-on-quality-of-life-brain-and-burnout-of-alzheimer-patients-informal-caregivers-100605209","NCT07159542","MUSic Listening Impact on QUality of Life, Brain and Burnout of ALzheimer' Patients Informal Caregivers","MUSIQUAL+","Inclusion Criteria:\n\n* Native language: French\n* Medical, neurological, neuropsychological and neuroradiological depth in accordance with the criteria for inclusion and exclusion-specific population, that is to say:\n\n  * Informal Caregivers: Being a carer for someone with neurodegenerative cognitive disorders (NCD), living at home, without memory complaints, normal performances compared to the age and the educational level for all tests of the diagnostic battery.\n  * Patients with neurodegenerative cognitive disorders: presenting neurodegenerative cognitive disorders, have an identified informal caregiver.\n\nExclusion Criteria:\n\n* A chronic neurological, psychiatric, endocrine, hepatic or infectious complaint\n* A history of major disease (an uncontrolled diabetes, a lung, heart, metabolic, hematologic, endocrine disease or a severe cancer);\n* A medication that may interfere with memory or metabolic measures",{"count":655,"type":23},90,[26],"Although life expectancy is increasing, the risk of dependence and\u002For loss of autonomy is increasing too with ageing. Alzheimer's disease affects many people and this kind of disease is constantly growing. Today, relatives of these sick people are increasingly taking on the role of carer to help them remain at home as long as possible. This situation of assistance has often a negative impact on the quality of life of the caregiver, which in some cases can lead to the caregiver burnout and increase the risk factors for developing pathological ageing. This situation can also damage the relationship and the quality of interactions between patient\u002Fcaregiver dyad. Non-pharmacological therapies and the use of digital tools appear to be promising avenues to fight psychological distress and social isolation, but also to improve the quality and duration of homecare services, by promoting the autonomy of the patient. The MUSIQUAL+ study aims to evaluate the impact of music listening offered to caregivers, alone or with their sick relative, on the quality of life and the exhaustion felt by the caregiver. Three times 20-minute sessions a week of music listening at home through the use of a tablet application, for 12 weeks, will be proposed. In addition to the collection of subjective feelings of the caregivers, a neuropsychological evaluation of the patient and the caregiver will be carried out on 90 dyads divided. Finally, in order to better understand the cerebral mechanisms involved and to provide evidence of the effect of this intervention, an EEG recording will be made before and after the musical listening. This study proposes a therapeutic and preventive alternative to drug treatments and to the currently unsatisfactory support of patients and their caregivers in distress; its benefits will be assessed too.",[659,660],"Alzheimer Dementia (AD)","Caregivers",[660,662,663],"Music intervention","Alzheimer","2025-09-05",{"date":666,"type":40},"2025-09-08",{"date":643,"type":23},{"date":669,"type":23},"2027-12",{"name":46,"class":47},""]