[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University Hospital Fattouma Bourguiba\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100553646","phase-2-nebulised-colistimethate-sodium-to-prevent-pediatric-ventilator-associated-pneumonia-100553646",false,"NCT06488794","Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia","Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia: The COLIPED Investigation","ColiPed","Inclusion Criteria:\n\n* Children older than 1 month and younger than 14 years\n* Patients on invasive mechanical ventilation for more than 48 hours\n* Informed parental consent\n\nExclusion Criteria:\n\n* Suspected or confirmed VAP on the day of inclusion\n* Indication for systemic colistin therapy before or at enrolment in the study\n* Plan for extubation within the next 24H\n* Known allergy to colistin\n* No parental consent\n* Tracheostomy\n* Appearance of allergic clinical manifestations in the days of colistin nebulization\n* Appearance of undesirable clinical or biological manifestations presumed attributable to nebulization with colistin","ALL","1 Month","14 Years",{"count":21,"type":22},400,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE2","PHASE3","The goal of this clinical trial is to learn if nebulized colistimethate sodium can prevent pneumonia in ventilated children. The main question it aims to answer is:\n\n• Does nebulized colistimethate sodium lower the number of times participants develop ventilation associated pneumonia? Researchers will compare nebulized colistimethate sodium to a placebo (a look-alike substance that contains no drug) to see if nebulized colistin works to prevent ventilation associated pneumonia in children.\n\nParticipants will:\n\n* Take nebulized colistimethate sodium or a placebo twice a day for a maximum of 7 days.\n* Will be followed to check for pneumonia occurrence while they are on mechanical ventilation.",[29],"Ventilator Associated Pneumonia",[31,32,33,34,35,36],"colistin","mechanical ventilation","pneumonia","nebulization","prevention","pediatrics","NOT_YET_RECRUITING","2026-02-20",{"date":40,"type":41},"2026-02-24","ACTUAL",{"date":43,"type":22},"2027-01-01",{"date":45,"type":22},"2028-12-31",{"name":47,"class":48},"University Hospital Fattouma Bourguiba","OTHER",""]