[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University Hospital Olomouc\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":300},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,42,75,100,126,155,184,213,235,271],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100637418","early-phase-1-development-of-a-preparation-for-supportive-supplementation-of-probiotics-in-patients-with-reflux-100637418",false,"NCT07600008","Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux","Inclusion Criteria:\n\n* Diagnosed GERD.\n* Stable health without current complications.\n* Patients on stable pharmacological PPI therapy (rabeprazole).\n\nExclusion Criteria:\n\n* Use of probiotics or prebiotics within the last 4 weeks.\n* Pregnancy or breastfeeding.\n* Systemic antimicrobial therapy within the last 4 weeks.\n* Infectious disease of the respiratory or gastrointestinal tract within the last 2 weeks.\n* Serious chronic disease that could affect study results, including cancer, diabetes, inflammatory bowel disease, diagnosed SIBO.\n* Prior surgeries, especially fundoplication and resections of the esophagus or stomach.\n* Patients with psychiatric or cognitive disorders.\n* Hypersensitivity to components of the investigational product.","ALL","40 Years","55 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","A two-arm, double-blind, randomized, placebo-controlled study investigating the efficacy of a probiotic preparation developed as supportive supplementation of probiotics in patients with reflux.\n\nThe objective of this trial is to evaluate the effect of the probiotic dietary supplement on the diversity and composition of the gut microbiome in patients diagnosed with GERD who are on PPI therapy. The study will also monitor changes in the oral microbiome and the impact of probiotic supplementation on patient quality of life and GERD symptoms.\n\nPatients will take the probiotic preparation, 2 tablets twice daily (morning before meals and evening after meals). The experimental phase will last 6 weeks. Patients in the control arm will receive placebo. Supplementation will be discontinued if adverse effects occur.\n\nOral and rectal swabs will be taken before and after administration of the preparation. Patients will monitor their symptoms using a questionnaire.",[26,27,28],"Reflux Disease","Microbiome","Probiotics Supplement","RECRUITING","2026-05-17",{"date":32,"type":33},"2026-05-20","ACTUAL",{"date":35,"type":33},"2026-01-15",{"date":37,"type":20},"2026-07-30",{"name":39,"class":40},"University Hospital Olomouc","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":41},"100598760","screening-mammography-single-reading-by-one-radiologist-with-ai-vs-double-reading-by-two-radiologists-ai-bcsq-100598760","NCT07075679","Screening Mammography: Single Reading by One Radiologist With AI vs. Double Reading by Two Radiologists (AI-BCSQ)","Use of Artificial Intelligence in Breast Cancer Screening: Impact of AI-Assisted Single Reading by One Radiologist on Screening Quality Indicators Compared to Standard Double Reading by Two Radiologists Without AI","AI-BCSQ","Inclusion Criteria:\n\n* age 45-69, asymptomatic woman participating in breast cancer screening programme\n\nExclusion Criteria:\n\n* clinical signs of breast disease - indication for diagnostic mammography",true,"FEMALE","45 Years","69 Years",{"count":55,"type":20},8000,[57],"NA","A randomized prospective study comparing the evaluation of mammography images in a breast cancer screening programme by a single radiologist with AI support versus standard double reading by two radiologists without AI support.",[60,61,62],"Breast Cancer Screening","Artificial Intelligence (AI)","Breast Cancer Screening and Diagnosis",[64,65,66],"breast cancer","screening","artificial intelligence","2026-04-01",{"date":69,"type":33},"2026-04-02",{"date":71,"type":33},"2025-10-06",{"date":73,"type":20},"2028-10-05",{"name":39,"class":40},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":50,"sex":15,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":41},"100620319","the-use-of-electrical-impedance-tomography-eit-in-pulmonary-diseases-100620319","NCT07356076","The Use of Electrical Impedance Tomography (EIT) in Pulmonary Diseases","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Individuals diagnosed with any of the following lung diseases, as these are the primary focus of the study: Chronic obstructive pulmonary disease, Asthma, Pulmonary fibrosis, Pneumonia, Patients with a history of COVID-19 infection showing residual pulmonary findings.\n* Additionally, healthy subjects will be enrolled to obtain normal standard values (with normal physical examination and no respiratory symptoms, BMI 18-36 - cause EIT performance can be BMI dependent, Non-smokers or ex-smokers abstinent ≥12 months)\n* Ability to perform spirometry while seated, except for possible participants who are specifically part of a subgroup analysis where inability to perform spirometry is the condition which is studied.\n\nSigning of an informed consent that has been approved by the ethics committee\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Severe cardiovascular disease\n* Pregnancy\n* Inability to express consent\n* Acute respiratory infection: Except for those recovering from pneumonia or COVID-19 within the study focus, participants with current respiratory infections will be excluded to avoid confounding effects on lung function tests\n* Inability to perform spirometry","18 Years",{"count":83,"type":20},400,"OBSERVATIONAL","The study titled \"The Use of Electrical Impedance Tomography (EIT) in Pulmonary Diseases\" investigates the impact of using EIT as a non-invasive method to monitor the distribution of pulmonary ventilation and its relationship to standard spirometry in patients with various lung diseases. The main aim of this study is to investigate new approaches to the assessment of lung status and diagnosis of lung diseases.\n\nUnlike spirometry, which has long been a well-known and important diagnostic tool in pulmonary medicine, and which provides valuable information about the volume and flow of inspired and expired air, EIT provides spatial information about the distribution of ventilation in real time and without the need for active patient cooperation. Research and practice have shown that spirometry is problematic in specific groups of patients, such as patients with tracheostomy or facial palsy. The technology should also enable detection of the disease in its early stages, when treatment is most effective.\n\n300 participants in the experimental group and 100 participants in the control group will receive spirometry and electrical impedance tomography independent examination.\n\nThe primary endpoint of the study is to investigate the potential of EIT in respiratory medicine, specifically identifying the relationship between EIT and traditional spirometry. This effort is motivated by the need for novel noninvasive methods for the diagnosis and monitoring of respiratory diseases, especially in patients unable to undergo conventional spirometry, or in case of interventions requiring real-time feedback. The purpose of the research project in relation to these objectives is to bring new possibilities in the field of diagnosis and monitoring of lung diseases through EIT, which could lead to significant improvements in patient care.\n\nDemographic and anthropometric data, including age, sex, body height, body weight, body mass index (BMI), chest circumference, and smoking history will be collected in all participants. These parameters will be used as covariates in the analysis to assess their impact on EIT-derived indicators and to improve normalization of EIT signals.\n\nAdditionally, the study aims to develop and validate a machine learning model, particularly a deep neural network, capable of predicting standard spirometric parameters (e.g., FEV1, FVC, PEF) based solely on EIT signals. This could allow for an accurate assessment of dynamic pulmonary volumes in cooperating patients who are unable to undergo conventional spirometry (e.g. patients with tracheostomy).",[87],"Lung Diseases",[89,90,87,91],"Electrical Impedance Tomography","Spirometry","Lung Assessment","2026-01-25",{"date":94,"type":33},"2026-01-27",{"date":96,"type":33},"2025-11-01",{"date":98,"type":20},"2028-12-31",{"name":39,"class":40},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":15,"minAge":81,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":110,"conditions":111,"keywords":114,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":124,"leadSponsor":125,"locationsCount":41},"100620689","early-detection-of-selected-neuropathologies-in-motor-vehicle-drivers-100620689","NCT07360886","Early Detection of Selected Neuropathologies in Motor Vehicle Drivers","NeuroDrive","Inclusion Criteria:\n\n* Person after signing informed consent.\n* After meeting the valid diagnostic criteria for the given neurological diagnosis.\n* Possession of a valid driver's license and proof of active driving.\n* Age limit 18 - 85 years.\n\nExclusion Criteria:\n\n* Proven diagnosis of dementia based on a current psychological examination (MMSE 24 points or less).\n* Diagnosis of a disease or condition that, according to Czech Law. No. 277\u002F2004 Coll., on medical fitness to drive motor vehicles, as amended (especially Law No. 204\u002F2025 Coll.), prevents or significantly limits the ability to drive a motor vehicle safely (e.g. dementia, epilepsy, severe disorders of consciousness).\n* Age less than 18 years.\n* Age more than 85 years.\n* In the second cohort (patients with Multiple Sclerosis), proven and treated relapse in the last 6 weeks before inclusion in the study.\n* In the MS cohort, current EDSS \\> 6.5 points.\n* For the PD cohort, the current Hoehn and Yahr scale score is greater than or equal to 4.\n* For both cohorts, evidence of parainfectious deterioration as demonstrated by laboratory testing.","85 Years",{"count":109,"type":20},200,"This study aims to develop accessible methods for the early detection of selected neuropathologies in drivers, focusing on multiple sclerosis and Parkinson's disease. The primary objective is to identify clinical tests that correlate with outcomes from the Vienna Test System (VTS), thereby enabling early diagnosis without the need for complex neurological or neuropsychological assessments. Findings could improve the effectiveness of routine driver medical check-ups and inform future modifications to Czech traffic law to enhance road safety.",[112,113],"Multiple Sclerosis","Parkinson Disease",[115,116,117,118,119],"Neurology","Psychology","Traffic psychology","Vienna Test System","Driving abilities","2026-01-13",{"date":122,"type":33},"2026-01-22",{"date":96,"type":33},{"date":98,"type":20},{"name":39,"class":40},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":15,"minAge":81,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":21,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":41},"100590208","raman-spectroscopy-in-the-diagnosis-of-extrahepatic-cholangiocarcinoma---a-pilot-study-100590208","NCT06964425","Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma - a Pilot Study","Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma","Inclusion Criteria:\n\n* person older than 18 years, who has known extrahepatic cholangiocarcinoma and is indicated for ERCP\n\nExclusion Criteria:\n\n* disagreement with the study",{"count":134,"type":20},20,[57],"Diagnosis of extrahepatic cholangiocarcinoma is challenging because the yield of imaging and tissue sampling is limited. Raman spectroscopy is an optical method based on the analysis of scattered monochromatic light. Raman spectroscopy is able to provide a molecular 'fingerprint' of the tissue to determine its type. The aim of this pilot study was to develop a methodology for in vivo Raman spectroscopy in bile ducts to improve the current diagnostic capabilities of extrahepatic cholangiocarcinoma.",[138,139,140,141,142,143,144,145,146],"Cholangiocarcinoma, Extrahepatic","Cholangiocarcinoma of the Extrahepatic Bile Duct","Cholangiocarcinoma, Perihilar","Diagnosis","Raman Spectroscopy","Klatskin Tumor","Endoscopy","Biliary Stricture","Malignant Biliary Stricture","2025-06-29",{"date":149,"type":33},"2025-07-02",{"date":151,"type":33},"2023-02-04",{"date":153,"type":20},"2025-07-30",{"name":39,"class":40},{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":161,"minAge":16,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":21,"phases":164,"briefSummary":165,"conditions":166,"keywords":170,"overallStatus":175,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":41},"100591484","the-effectiveness-of-telemedicine-monitoring-prehabilitation-in-prostate-cancer-patients-undergoing-radical-prostatectomy-100591484","NCT06981026","The Effectiveness of Telemedicine Monitoring Prehabilitation in Prostate Cancer Patients Undergoing Radical Prostatectomy","Inclusion criteria:\n\n* Biopsy-confirmed localized prostate cancer (ICD code C.61).\n* Indicated for radical prostatectomy, with or without pelvic lymphadenectomy (ePLND).\n* Not previously treated for prostate cancer, including radiation therapy to the pelvis, major pelvic surgery, or placement of a penile implant or artificial urinary sphincter.\n* No known urethral stricture or colostomy or chronic urinary catheterization.\n* No medical or current psychiatric disorders that precludes their participation in the study.\n* Status of the musculoskeletal system allowing physical exercise.\n* Urinary continent at baseline.\n* Has reliable internet and the skills\u002Fknowledge to use technologies use for the study.\n\nExclusion criteria:\n\n* Other malignant tumors, except for benign skin carcinoma.\n* Active treatment for other oncological diagnoses.\n* Presence of preoperative urinary incontinence.\n* Diagnosed mental or cognitive disorders.\n* Prior pelvic radiotherapy or hormone therapy for prostate cancer recurrence.\n* Severe musculoskeletal disorders preventing active exercise\n* Inability to use required technologies","MALE","80 Years",{"count":109,"type":20},[57],"The study titled \" The effectiveness of telemedicine monitoring prehabilitation in prostate cancer patients undergoing radical prostatectomy \" investigates the impact of a structured telemedicine-supported prehabilitation and rehabilitation program on reducing postoperative urinary incontinence in patients with localized prostate cancer. Radical prostatectomy, a common treatment for localized prostate cancer, is often associated with complications such as urinary incontinence, which significantly affects quality of life. This study aims to address this issue by enhancing patients' physical conditioning and adherence to pre- and postoperative rehabilitation through the use of wearable devices and remote physiotherapy consultations.",[167,168,169],"Prostatectomy","Prehabilitation","Telemedicine",[167,171,169,172,173,168,174],"Physiotherapy","eHealth","Oncology","Rehabilitation","NOT_YET_RECRUITING","2025-05-12",{"date":178,"type":33},"2025-05-20",{"date":180,"type":20},"2026-01-01",{"date":182,"type":20},"2028-09-30",{"name":39,"class":40},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":15,"minAge":81,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":21,"phases":194,"briefSummary":195,"conditions":196,"keywords":201,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":212},"100466035","fmiso-based-adaptive-radiotherapy-for-head-and-neck-cancer-100466035","NCT05348486","FMISO-based Adaptive Radiotherapy for Head and Neck Cancer","FMISO-based Adaptive Radiotherapy for Head and Neck Cancer - a Prospective Multicenter Study","FARHEAD","Inclusion Criteria:\n\n* Pathologically proven new diagnosis of oropharyngeal p16 negative, or laryngeal, hypopharyngeal, oral cavity (independent of p16) squamous cell carcinoma of clinical stage III, IV confined to head and neck area\n* Evaluable tumor burden assessed by computed tomography scan or magnetic resonance imaging, based on RECIST (Response Evaluation Criteria in Solid Tumours) version 1.1\n* Eligibiity for definitive chemoradiation or hyperfractionated accelerated radiotherapy\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1\n* Adequate kidney and liver function\n\nExclusion Criteria:\n\n* Prior surgical treatment - any surgery of primary tumor or involved nodes or prior surgical debulking apart from surgery with diagnostic intention (e.g. open biopsy if necessary)\n* Prior systemic therapy, targeted therapy, radiotherapy treatment for head and neck cancer\n* Cancer outside of the oropharynx, larynx, and hypopharynx or oral cavity, such as nasopharyngeal, sinus, other para-nasal, or unknown primary head and neck cancer\n* Known active central nervous system (CNS) metastases and\u002For carcinomatous meningitis or any distant metastasis\n* Known active Hepatitis B or C\n* History of Human Immunodeficiency Virus (HIV)\n* History of a diagnosed and\u002For treated hematologic or primary solid tumor malignancy, unless in remission for at least 5 years prior to randomization\n* Previous allogeneic tissue\u002Fsolid organ transplant\n* Active infection requiring systemic therapy",{"count":193,"type":20},120,[57],"Hypoxia occurs in about 80% of head and neck tumors. Based on experimental and clinical data, hypoxia is a useful parameter for pretherapeutic stratification. These radioresistant regions can be detected with FMISO PET\u002FCT. Moreover, hypoxic subvolumes of tumors can be evolving as target volumes for radiotherapy (\"dose painting\") in hypoxia imaging-based dose escalation.",[197,198,199,200],"Head and Neck Cancer","Hypoxia","FMISO","Dose Escalation",[197,198,202,203],"Radiotherapy","Dose escalation","2025-04-16",{"date":206,"type":33},"2025-04-22",{"date":208,"type":33},"2022-04-20",{"date":210,"type":20},"2030-06-30",{"name":39,"class":40},3,{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":15,"minAge":81,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":221,"conditions":222,"keywords":225,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":41},"100522668","impact-of-significant-carotid-stenosis-on-retinal-perfusion-measured-via-automated-retinal-oximetry-100522668","NCT06085612","Impact of Significant Carotid Stenosis on Retinal Perfusion Measured Via Automated Retinal Oximetry","Inclusion Criteria:\n\nStudy population will include patients examined in ultrasound laboratory in Neurology department of University Hospital Olomouc, regardless of incidental finding of stenosis, examination due to acute symptoms or regular checkup of known stenosis.\n\nExclusion Criteria:\n\n* patients unable undergo ophthalmological examination properly, especially on automated retinal oximetry.",{"count":220,"type":20},150,"Background: Large vessel carotid stenosis represent significant cause of ischaemic stroke. Indication for surgical revascularisation treatment relies on severity stenosis and clinical symptoms. Mild clinical symptoms such as transient ischemic attack, amaurosis fugax or minor stroke preceded large strokes in only 15% of cases.\n\nAim: The aim of this prospective study is to evaluate whether retinal perfusion is impacted in significant carotid stenosis. Automated retinal oximetry could be used to better evaluate perfusion in post-stenotic basin. The investigators presume the more stenotic blood vessel, the more reduced retinal perfusion is resulting in adaptive changes such as higher arteriovenous saturation difference due to greater oxygen extraction. This could help broaden the indication spectrum for revascularisation treatment for carotid stenosis.\n\nMethods: The investigators plan to enroll 50 patients a year with significant carotid stenosis and cross-examine them with retinal oximetry. Study group will provide both stenotic vessels and non-stenotic vessels forming the control group. Patients with significant carotid stenosis will undergo an MRI examination to determine the presence of asymptomatic recent ischaemic lesions in the stenotic basin, and the correlation to oximetry parameters.\n\nStatistics: Correlation between the severity of stenosis and retinal oximetry parameters will be compared to the control group of non-stenotic sides with threshold of 70%, respectively 80% and 90% stenosis. Data will be statistically evaluated at the 5% level of statistical significance. Results will be then reevaluated with emphasis on MRI findings in the carotid basin.\n\nConclusion: This prospective case control study protocol wil be used to launch a trial assessing the relationship between significant carotid stenosis and retinal perfusion measured via automated retinal oximetry.",[223,224],"Stroke, Ischemic","Stenosis, Carotid",[226],"automated retinal oximetry","2023-10-18",{"date":229,"type":33},"2023-10-23",{"date":231,"type":33},"2023-01-01",{"date":233,"type":20},"2028-01-01",{"name":39,"class":40},{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":15,"minAge":81,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":244,"conditions":245,"keywords":259,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":41},"100519938","surgical-treatment-of-adrenal-diseases--laparoscopic-vs-robotic-assisted-adrenalectomy-100519938","NCT06050057","Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy","Possibilities of Surgical Treatment of Adrenal Diseases: Comparison of Laparoscopic and Robotic-assisted Adrenalectomy-a Prospective Study","Inclusion Criteria:\n\n* Indicated adrenalectomy based on endocrinological and imaging examination.\n* Written consent to participate in the study.\n\nExclusion Criteria:\n\n* Simultaneous bilateral adrenalectomy.\n* Adrenal expansion \\> 12 cm.\n* Suspected malignant adrenal tumor with infiltrative growth or tumor venous thrombus according to imaging examination.",{"count":243,"type":20},100,"The goal of this multicenter, observational, analytic, randomized clinical trial is to analyze the laparoscopic and robot-assisted method in the surgical treatment of patients with adrenal diseases. The main question it aims to answer are:\n\n1. to find the superiority of one the the surgical method mentioned above\n2. to compare the quality of life in patients with adrenal mass before surgery and after laparoscopic or robotic-assisted adrenalectomy.",[246,247,248,249,250,251,252,253,254,255,256,257,258],"Adrenal Tumor","Adrenal Disease","Adrenal Mass","Adrenalectomy; Status","Adrenal Hyperplasia","Adrenal Gland Metastasis","Adrenal Cortex Diseases","Pheochromocytoma","Cushing Syndrome","Conn Adenoma","Adrenocortical Carcinoma","Adrenocortical Adenoma","Adrenocortical Tumor",[246,253,255,254,260,261,262],"Adrenalectomy","Laparoscopic surgery","da Vinci surgical system","2023-09-17",{"date":265,"type":33},"2023-09-22",{"date":267,"type":33},"2023-09-03",{"date":269,"type":20},"2026-06-30",{"name":39,"class":40},{"id":272,"slug":273,"hasResults":11,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":277,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":15,"minAge":81,"maxAge":162,"enrollmentInfo":279,"targetDuration":4,"studyType":21,"phases":280,"briefSummary":281,"conditions":282,"keywords":284,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":41},"100425784","gait-recovery-in-patients-after-acute-ischemic-stroke-100425784","NCT04824482","Gait Recovery in Patients After Acute Ischemic Stroke","GAIT Recovery in Patients aFter Acute Ischemic STroke: A Randomized Comparison of Robot-assisted and Therapist-assisted Gait Training on a Treadmill.","GAITFAST","Inclusion Criteria:\n\n* Ischemic stroke detected on magnetic resonance imaging (MRI) with NIHSS score 1-12 points at the time of enrolment\n* Lower limb movement impairment with a score of at least 1 point on the NIH Stroke Scale (NIHSS) at the time of enrolment\n* Dependency in walking according to Functional Ambulatory Category (FAC) with score interval \\\u003C1,3\\> (supervision or assistance, or both, must be given in performing walking)\n\nExclusion Criteria:\n\n* Previous history of any stroke, either ischemic or hemorrhagic\n* Other diseases modifying or limiting walking ability, currently receiving rehabilitation or participation in another study\n* Significant\u002Fsymptomatic ischemic heart disease or significant\u002Fsymptomatic peripheral arterial disease\n* Obesity (BMI ≥ 40), or weight higher than 110 kg (weight limit for the robot-assisted gait training)\n* Sensory aphasia with the inability to understand having been verified by a certified speech therapist.\n* Moderate or severe depression present at the time of enrolment assessed using the Beck scale, with a score above 10.\n* Known cognitive impairment\n* Previous disability or dependence in the daily activities assessed using the modified Rankin Scale with a score of 3 and more points\n* Currently receiving dialysis\n* Diagnosed and\u002For receiving treatment for cancer\n* Presence of other orthopedic or neurological conditions affecting the lower extremities\n* For fMRI: Pregnancy; electronic implants, including cochlear implant, pacemaker, neurostimulator; incompatible metallic implants, including aneurysm clip; metallic intraocular foreign body; large tattoos; unremovable piercing; body weight over 150 kg; known claustrophobia",{"count":193,"type":20},[57],"More than 80% of ischemic stroke (IS) patients have some walking disability, which restricts their independence in the activities of daily living. Physical therapy (PT) significantly contributes to gait recovery in patients after IS. However, it remains unclear, what type of gait training is more effective and which factors may have impact on gait recovery. Two hundred fifty IS patients will be enrolled to undergo a 2-week intensive inpatient rehabilitation including randomly assigned robot-assisted treadmill gait training (RTGT) or therapist-assisted treadmill gait training (TTGT). A detailed clinical and laboratory assessment of gait quality, as well as the degree of neurological impairment, quality of life, cognition and depression will be performed in all patients during the study. We hypothesize that these variables may also affect gait recovery in patients after IS. In a randomly selected 60 enrolled patients, a multi-modal magnetic resonance imaging (MRI), including functional MRI, will be performed to assess neural correlates and additional predictors of gait recovery.",[283],"Ischemic Stroke",[283,285,286,287,288,289,290,291],"Stroke rehabilitation","Physical Therapy","Gait","Exoskeleton Device","Walking speed","Gait Analysis","Functional Magnetic Resonance Imaging","2022-07-27",{"date":294,"type":33},"2022-07-29",{"date":296,"type":33},"2020-09-01",{"date":298,"type":20},"2026-12-31",{"name":39,"class":40},""]