[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University Hospital Pilsen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":165},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,82,112,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100636801","quantification-of-peripheral-blood-inkts-after-allogeneic-stem-cell-transplantation-100636801",false,"NCT07570407","Quantification of Peripheral Blood iNKTs After Allogeneic Stem Cell Transplantation","Standardised Quantification of Invariant NKT Cells Using DryTube Technology and Flow Cytometry in Patients Who Have Undergone Allogeneic Haematopoietic Stem Cell Transplantation.","QiNKT-HSCT","Inclusion Criteria:\n\n* Diagnosis: AML (exlusion of secondary disease)\n* Disease status at time of HSCT: complete remission\n* Karnofsky performance status: ≥80%\n* Source of HSC: PBSC\n\nExclusion Criteria:\n\n* Prior transplant\n* Uncontrolled Malignancy","ALL","18 Years","70 Years",{"count":21,"type":22},75,"ESTIMATED","OBSERVATIONAL","The transplantation of allogeneic haematopoietic stem cells (HSCs) can lead to serious complications after transplantation, such as graft-versus-host disease (GvHD), infections and relapse due to immunosuppression. Invariant NKT cells (iNKT cells) play a pivotal role in modulating the immune response and have been demonstrated to be instrumental in the pathogenesis of GvHD, cytomegalovirus (CMV) infection, and relapse. Their levels are associated with the development of these complications. This multicentre study aims to test the feasibility of standardising iNKT cell monitoring and to investigate the association between iNKT cell levels and post-transplant complications.",[26,27,28,29,30],"Allogeneic HSCT","Posttransplant Complications","GvHD","Relapse","Acute Myeloid Leukemia",[32,33,34,35],"iNKT cells","HSCT","Flow cytometry","Reconsitution","NOT_YET_RECRUITING","2026-04-29",{"date":39,"type":40},"2026-05-06","ACTUAL",{"date":42,"type":22},"2026-05-01",{"date":44,"type":22},"2029-01-31",{"name":46,"class":47},"University Hospital Pilsen","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":48},"100614924","the-role-of-stress-in-cardiac-arrest-cortizol-cpr-100614924","NCT07285915","The Role of Stress in Cardiac Arrest (Cortizol CPR)","Stress as a Key Factor Influencing the Onset and Course of Cardiac Arrest","Cortizol","Inclusion Criteria:\n\n* Cardiac arrest\n* Heart attack\n* 18 - 100 years\n\nExclusion Criteria:\n\n* Disapproval patient´s relatives with the study\n* Chronical treatment with corticoids and antidepresives","100 Years",{"count":59,"type":22},136,"INTERVENTIONAL",[62],"NA","The aim of this study is to assess long-term stress in patients after an out-of-hospital cardiac arrest. To do this, we will measure levels of the stress hormone cortisol in hair samples. Cortisol is produced in larger amounts during periods of ongoing stress and builds up in the hair as it grows. Because hair grows about 1 cm per month, a 3 cm hair sample can show your average stress level over the past three months. The results will be compared with anonymized information from your medical records and the care you received before and during your hospital stay.",[65,66,67,68],"Chronic Stress","Cardiac Arrest (CA)","Post-Resuscitation Syndrome","Heart Attack",[70,71,72,73],"cardiac arrest","chronic stress","kortizol","hair","RECRUITING","2026-04-27",{"date":42,"type":40},{"date":78,"type":40},"2026-01-08",{"date":80,"type":22},"2027-10-31",{"name":46,"class":47},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":17,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":48},"100587091","comparison-of-skin-prick-testing-extract-specific-ige-antibody-testing-and-component-resolved-diagnosis-in-diagnosing-of-legume-allergy-100587091","NCT06923878","Comparison of Skin Prick Testing, Extract-specific IgE Antibody Testing and Component Resolved Diagnosis in Diagnosing of Legume Allergy","Comparison of Prick-to-prick Testing, Extract-specific IgE Antibody Testing and Component Resolved Diagnosis (CRD) in Diagnosing of Allergy to Peas, Lentils, Chickpeas and Green Beans","CRD","Inclusion Criteria:\n\n* age: ≤ 65 years\n* signing informed consent to the study\n* a positive history of an immediate allergic reaction to one or more of the legumes studied (peas, lentils, chickpeas, beans) with skin, gastrointestinal, respiratory or cardiovascular symptoms occurring within 2 hours after ingestion and a positive result of specific IgE testing against ALEX and\u002For skin prick test with the legume\n* patients with a positive OFC with any of the legumes studied\n\nExclusion Criteria:\n\n* disagreement with the implementation of the oral food challenge\n* history of severe systemic allergic reaction to the legume in question (Ring-Messmer grade ≥ 3)",true,"4 Months","65 Years",{"count":94,"type":22},100,"The study is aimed at improving the diagnosis of food allergy, specifically allergy to commonly consumed legumes such as peas, lentils, chickpeas or green beans. Patients suspected of allergy to these legumes will be examined using traditional methods of IgE-mediated allergy diagnosing (skin prick test, testing for specific IgE antibodies against food extract), but also by testing for specific IgE antibodies against relevant allergenic molecules of these legumes. The results of performed tests will be compared with the result of the oral food challenge, which is considered to be the gold standard of food allergy diagnosis.",[97],"Food Allergy Suspected",[99,100,101,102,103],"food allergy","component resolved diagnosis","skin prick test","oral food challenge","legume allergy","2026-04-08",{"date":106,"type":40},"2026-04-09",{"date":108,"type":40},"2023-10-01",{"date":110,"type":22},"2029-03-31",{"name":46,"class":47},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":60,"phases":123,"briefSummary":117,"conditions":125,"keywords":128,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":136,"locationsCount":48},"100564814","phase-2-study-solace-sepsis-100564814","NCT06634069","Study SOLACE SEPSIS","A Pilot, Randomized, Double-Blinded, Controlled Study of Hemodynamic and Acid Base Effects of 0.5M Sodium Lactate and 3% Saline Solutions in Septic Shock Patients","MJIP1_0","Inclusion Criteria:\n\n* Subjects will be eligible for the trial if they meet all of the following criteria:\n\n  1. Age criteria: 18 - 90 years\n  2. Septic shock - Sepsis 3 criteria :\n\n     1. acute change in total SOFA score ≥ 2 due to infection\n     2. use of vasopressor drug to maintain target mean arterial pressure ≥ 65 mmHg\n     3. blood lactate level ≥ 2 mmol\u002FL within last 24 hours\n  3. Likely need for fluid resuscitation\n\n     1. poor peripheral perfusion as evidenced by 2 out of 4: i. peripheral cyanosis with delayed capillary refill ≥ 3 seconds ii. low urinary output (\\\u003C 0.5 ml\u002Fkg\u002Fhour for at least 6 hours) iii. central venous O2 saturation \\\u003C 70% iv. clouded sensorium\u002Fpoor mentation\n     2. dynamic assessment of preload responsiveness as evidenced by 1 out of 3: i. positive passive leg raising test ii. pulse pressure variation and \u002F or stroke volume variation2, both \\> 12% iii. distensibility index of inferior vena caval diameter \\> 12%\n  4. Signed the relevant informed consent form\n\nExclusion Criteria:\n\n* Subjects will not be eligible for the trial if they meet any of the following criteria:\n\n  1. Poor transthoracic echo windows\n  2. Actual body weight \\> 160 kg\n  3. Hypernatremia: \\[Na\\] \\> 150 mEq\u002FL\n  4. Cardiac tamponade\n  5. Uncorrected severe valvular heart disease or life-threatening arrhythmia\n  6. Moribund patients likely to die before the study protocol is completed\n  7. Patients with absolute indication for immediate acute hemodialysis\u002Fhemofiltration (within 2 hrs) based on pH \\\u003C 7.0, K \\> 7.0mmol\u002FL\n  8. Severe liver dysfunction defined by total serum bilirubin \\> 120 umol\u002Fl\n  9. Pregnancy and lactation","90 Years",{"count":122,"type":22},40,[124],"PHASE2",[126,127],"Septic Shock","Intracranial Hypertension",[129,130],"intracranial hypertension","septic shock",{"date":132,"type":40},"2026-04-14",{"date":134,"type":40},"2024-11-24",{"date":80,"type":22},{"name":46,"class":47},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":144,"maxAge":18,"enrollmentInfo":145,"targetDuration":147,"studyType":23,"phases":4,"briefSummary":141,"conditions":148,"keywords":152,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":48},"100605256","cannabis-abstinence-and-neurocognitive-assessment-in-adolescence-100605256","NCT07160153","Cannabis Abstinence and Neurocognitive Assessment in Adolescence","CANAA","Inclusion Criteria:\n\n* Adolescents aged 15-18 years with a diagnosis of cannabis dependence or harmful cannabis use.\n\nExclusion Criteria:\n\n* psychiatric comorbidity - Dual diagnosis, including psychotic disorders, mood disorders, severe organic brain damage, or autism spectrum disorder, with the exception of compensated and stabilized anxiety disorder. Psychopharmacological treatment is permitted, except for antipsychotics prescribed for psychosis.\n* somatic comorbidity - Severe endocrine disorders such as diabetes mellitus, thyroid dysfunction, or severe cardiovascular disease.\n* Violation of abstinence between the first and second neuropsychological assessments, as well as severe decompensation of mental state requiring modification of established psychopharmacological treatment.","15 Years",{"count":146,"type":22},29,"2 Months",[149,150,151],"Cannabis Dependence","Harmful Use","Cognitive Assessment",[149,153,154,155,156],"Cannabis Use Disorder","Abstinence","Cognitive Function","Disorder; Abstinence; Cognitive Function; Neuropsychological","2025-09-15",{"date":159,"type":40},"2025-09-19",{"date":161,"type":40},"2024-12-03",{"date":163,"type":22},"2029-08-31",{"name":46,"class":47},""]