[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University Hospital of Mont-Godinne\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":119},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,66,90],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100375696","exploring-motor-learning-in-acute-stroke-through-robotics-100375696",false,"NCT04171856","Exploring Motor Learning in Acute Stroke Through Robotics","ACUTE STROKE PATIENTS:\n\nInclusion Criteria:\n\n* acute stroke (\\> 21 days)\n* aged 18-90 years\n* with a stroke lesion on brain imaging\n\nExclusion Criteria:\n\n* \" classical \" contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophoby, etc ...)\n* difficulty in understanding or executing commands\n* drug\u002Falcohol abuse\n* severe aphasia \u002F cognitive deficits interfering with study\n* inability to voluntarily move the affected arm (i.e. complete paralysis of the arm)\n* multiple strokes \u002F dementia \u002F psychiatric condition\n\nPATIENTS WITH TRANSIENT GLOBAL AMNESIA:\n\nClinical diagnosis, criteria of Hodge \\& Warlow (1990):\n\n* Anterograde amnesia observed by a witness\n* No alteration of consciousness or loss of identity\n* Cognitive dysfunction limited to amnesia\n* Lack of focused neurological deficit or argument for a comitiality\n* Absence of head trauma\n* Symptom resolution within 24 hours\n* Possible existence of vegetative symptoms\n\nInclusion criteria:\n\n* Transient global amnesia\n* 8-90 years old\n* Be able to perform 3 consecutive sessions on a rehabilitation robot\n\nExclusion criteria:\n\n* Severe aphasia \u002F cognitive deficits interfering with study\n* Psychiatric disorders\n* Alcohol \u002F drug addiction\n* Exclusion criteria related to MRI\n\nHEALTHY INDIVIDUALS:\n\nInclusion Criteria:\n\n• 18-90 years\n\nExclusion Criteria:\n\n* medical history with a previous stroke\u002Fneurological deficit\n* drug\u002Falcohol abuse\n* psychiatric condition\u002F dementia\n\nCHRONIC STROKE PATIENTS:\n\nInclusion Criteria:\n\n* chronic stroke (\\>6 months)\n* aged 18-90 years\n* with a stroke lesion on brain imaging\n\nExclusion Criteria:\n\n* difficulty in understanding or executing commands\n* drug\u002Falcohol abuse\n* severe aphasia \u002F cognitive deficits interfering with study\n* inability to voluntarily move the affected arm (i.e. complete paralysis of the arm)\n* multiple strokes \u002F dementia \u002F psychiatric condition",true,"ALL","18 Years","90 Years",{"count":20,"type":21},245,"ESTIMATED","INTERVENTIONAL",[24],"NA","The acute phase of stroke is characterized by an enhancement of neural plasticity which supports rapid motor recovery. It is unclear whether acute stroke patients can acquire new motor skills with their affected upper limb. The aims of this research program are:\n\n1. To test the capacity of acute stroke patients (\\\u003C 21 days) to learn and retain a complex unimanual motor skill.\n2. To explore whether acute stroke to different brain regions (quantified with brain MRI) induces specific deficits in motor skill learning.\n3. To compare acute stroke patients with healthy individuals and with chronic stroke patients.",[27],"Stroke, Acute",[29,30,31,32,33],"Acute stroke","Motor skill learning","Upper limb","Rehabilitation","Subacute stroke","RECRUITING","2025-03-31",{"date":37,"type":38},"2025-04-03","ACTUAL",{"date":40,"type":38},"2020-01-01",{"date":42,"type":21},"2040-07-01",{"name":44,"class":45},"University Hospital of Mont-Godinne","OTHER",2,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":60,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":46},"100360562","bimanual-motor-skill-learning-through-robotics-in-stroke-survivors-and-healthy-individuals-100360562","NCT03974750","Bimanual Motor Skill Learning Through Robotics in Stroke Survivors and Healthy Individuals","bimMsKL","STROKE PATIENTS :\n\nInclusion Criteria:\n\n* having a chronic stroke (\\>6 months)\n* aged 18-90 years\n* with demonstrate a stroke lesion on brain imaging.\n\nExclusion Criteria:\n\n* difficulty in understanding or executing commands\n* drug\u002Falcohol abuse\n* severe aphasia \u002F cognitive deficits interfering with study\n* inability to voluntarily move the affected arm (i.e. complete paralysis of the arm)\n* multiple strokes \u002F dementia \u002F psychiatric condition\n* botulinum toxin injections (to be evaluated)\n\nHEALTHY INDIVIDUALS :\n\nInclusion Criteria:\n\n\\- 18-90 years\n\nExclusion Criteria:\n\n* neurological conditions interfering with the study\n* drug\u002Falcohol abuse\n* pyschiatric condition",{"count":55,"type":21},100,[24],"To test the capacity of healthy and chronic stroke patients to learn and retain a complex bimanual motor skill, trained on the neurorehabilitation robot REAplan (R) (bimanual version).",[59],"Stroke",{"date":37,"type":38},{"date":62,"type":38},"2017-07-01",{"date":64,"type":21},"2030-12-31",{"name":44,"class":45},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":76,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":46},"100497715","bimanual-motor-skill-learning-in-acute-stroke-100497715","NCT05760846","Bimanual Motor Skill Learning in Acute Stroke","Exploring the Neural Substrates of Proximal and Distal Bimanual Motor Skill Learning Through Robotics and Multimodal Brain Imaging","MLAS4","ACUTE STROKE PATIENTS:\n\nInclusion Criteria:\n\n* acute stroke (\\\u003C 21 days)\n* aged 18-90 years\n* with a demonstrated stroke (ischemic or hemorrhagic) lesion on brain imaging\n\nExclusion Criteria:\n\n* \" classical \" contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...)\n* difficulty in understanding or executing commands\n* drug\u002Falcohol abuse\n* severe aphasia \u002F cognitive deficits interfering with study\n* inability to complete the tasks (i.e. full paralysis of the arm)\n* multiple strokes \u002F dementia \u002F psychiatric condition\n\nHEALTHY INDIVIDUALS:\n\nInclusion Criteria:\n\n• 18-90 years\n\nExclusion Criteria:\n\n* medical history with a previous stroke \u002F relevant neurological deficit\n* drug\u002Falcohol abuse\n* psychiatric condition\u002F dementia",{"count":75,"type":21},160,[24],"The subacute phase of stroke provides a window into how a lesion perturbs sensorimotor functions prior to reorganisation driven by plasticity and neurorehabilitation. The recovery from motor impairment has been extensively studied, but it is currently unknown whether motor skill learning (MSkL) is enhanced or impaired during acute stroke, especially bimanual motor skill learning (bim-MSkL), which likely requires more motor-attentional-cognitive resources than unimanual MSkL.\n\nThe goals of this project are: to determine the neural substrates critical to achieve proximal and distal bimanual motor skill learning (bim-MSkL) by specifying whether (sub)acute stroke to different brain areas (cortical and subcortical) induce specific deficits in bimanual and\u002For distal bim-MSkL, which behavioral components are involved in bim-MSkL, and whether damage to the motor, sensory and inter-hemispheric pathways specifically impairs proximal and\u002For distal bim-MSkL.",[27,79],"Stroke, Subacute",[81,31,29,32,33],"Motor Skill Learning","2024-12-10",{"date":84,"type":38},"2024-12-16",{"date":86,"type":38},"2023-04-17",{"date":88,"type":21},"2028-10",{"name":44,"class":45},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},"100478503","multiparametric-assessment-to-investigate-prognostic-factors-for-disease-evolution-a-nd-evolutionary-patterns-of-cognitive-status-in-rrms-100478503","NCT05510817","Multiparametric Assessment to Investigate Prognostic Factors for Disease Evolution a nd Evolutionary Patterns of Cognitive Status in RRMS","Multiparametric Clinical, Radiological, Neuropsychological, and Neurophysiological Assessment to Investigate Prognostic Factors for Disease Evolution and Treatment Response in MS: a Prospective Study.","COGNIT-MS","Inclusion Criteria:\n\n* active MS, according to the Lublin criteria\n* disease duration \\\u003C 10 years before initiating or changing a disease-modifying therapies,\n* relapse- and steroid-free for at least 1 month before MRI acquisition\n* between 18-50 years old\n* having given informed consent\n* with no significant comorbidity other than MS or substance abuse that could interfere with cognitive performances\n\nExclusion Criteria:\n\n* progressive forms of MS","50 Years",{"count":100,"type":21},50,[24],"This prospective study combining non conventional MRI techniques, neuropsychological screening tools, and a neurophysiological work-up using a sensitive and validated battery, will evaluate the predictive value of these measures and will explore the changes of the cognitive scores from baseline.",[104],"Multiple Sclerosis, Relapsing-Remitting",[106,107,108,109],"MRI","evoked potentials","cognitive function","PROMs","2023-12-03",{"date":112,"type":38},"2023-12-05",{"date":114,"type":38},"2022-06-06",{"date":116,"type":21},"2026-06-06",{"name":44,"class":45},1,""]