[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University Hospital of Split\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":87},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100602937","phase-4-preoperative-use-of-peripheral-nerve-blocks-in-elderly-patients-with-hip-fractures-100602937",false,"NCT07130006","Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures","Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures: a Factorial Randomized Clinical Trial","Inclusion Criteria:\n\n* both sexes\n* 60 years old and older\n* diagnosed with a hip fracture resulting from low-energy trauma\n* scheduled surgery.\n\nExclusion Criteria:\n\n* polytraumatized patients\n* dementia and acute psychosis patients\n* patients for whom spinal anesthesia is contraindicated\n* patients with severe renal failure\n* patients for whom intravenous administration of tranexamic acid is contraindicated\n* patients with proven allergy and contraindications to dexamethasone, non-steroidal anti-rheumatic drugs, opioid analgesics, magnesium sulfate.","ALL","60 Years",{"count":19,"type":20},256,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this clinical trial is to explore the effects of different peripheral nerve blocks in older adults with hip fractures. It will also explore the safety of preoperative administration of peripheral nerve blocks. The main questions this trial aims to answer are:\n\n* which peripheral nerve block is the best regarding analgesia\n* which peripheral nerve block eases positioning and decrease time necessary for applying spinal anesthesia?\n* which peripheral nerve block is associated with reduced intake of analgesics, both oral and intravenous?\n* which peripheral nerve block lasts long enough but does not interfere with the start of physical therapy?\n* what medical problems do respondents have during their hospitalization, after administration of peripheral nerve blocks, spinal anesthesia and surgery?\n* what medical problems arise as a consequence of their complex medical history? Researchers will compare respondents who receive peripheral nerve blocks to those who do not. Those who do not receive blocks will be given fentanyl preoperatively, which was until recently standard at our institution.\n\nAll respondents will, in addition to obligatory intraoperative monitoring,:\n\n* be thoroughly examined by anesthesiologists before surgery\n* be closely monitored after surgery, until their hospital discharge.",[26,27,28,29,30,31,32],"Fractures, Hip","Femoral Neck Fractures","Intertrochanteric Fractures","Subtrochanteric Fractures","Aged","Frail Older Adults","Elderly",[34,35,36,37,38,39,40,41,42,43],"elderly","ultrasound-guided","peripheral nerve blocks","intravenous fentanyl","spinal anaesthesia","EQ-5D-5L","visual analog scale","pain at rest","dynamic pain","hip fracture surgery","NOT_YET_RECRUITING","2025-08-11",{"date":47,"type":48},"2025-08-19","ACTUAL",{"date":50,"type":20},"2025-08-30",{"date":52,"type":20},"2026-03-31",{"name":54,"class":55},"University Hospital of Split","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":16,"minAge":64,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":21,"phases":67,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":56},"100561835","phase-1-comparison-between-epidural-analgesia-and-intrathecal-opioid-analgesia-for-pain-management-in-open-nephrectomy-100561835","NCT06595329","Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy","Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy: Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients over the age of 18, scheduled for an open radical or partial nephrectomy due to RCC.\n* American Society of Anesthesiologists (ASA) physical status classification I-III.\n\nExclusion Criteria:\n\n* Patients who refuse to participate in this study.\n* Patients with BMI \\> 35 kg\u002Fm2 or \\\u003C 15 kg\u002Fm2.\n* Patients with renal dysfunction (eGFR \\\u003C15 or requirement of renal replacement therapy), liver dysfunction (Child-Pugh class C), and heart failure (NYHA IV).\n* Patients with ASA physical status classification ≥ IV.\n* Patients with contraindication for the interventions planned for in this study (allergies to anesthetic drugs used in this study, coagulation disorders, and infection at the injection site).\n* Patients with chronic opioid dependence.\n* Patients unable to communicate preoperatively due to severe dementia, language barrier, or neuropsychiatric disorder.\n* Patients for whom it is impossible to carry out the aforementioned interventions for technical reasons.","18 Years",{"count":66,"type":20},40,[68],"PHASE1","Nephrectomy is a surgical procedure of choice for patients suffering from renal cell carcinoma (RCC). Even though the laparoscopic approach is considered to cause fewer complications and reduce hospital stay, open surgery is still often performed. Open nephrectomy causes significant acute postoperative pain, and it can also lead to the development of chronic postoperative pain. Pain management is important for the overall recovery of patients undergoing major surgery such as open nephrectomy and it is a part of the enhanced recovery after surgery (ERAS) program.\n\nIn this prospective randomized clinical study, we plan to compare two different approaches to pain management regarding the level of acute pain (first 72 hours), side effects, systemic analgesics consumption, and hospital stay.\n\nOur hypothesis are that intrathecal opioid administration significantly reduces acute postoperative pain compared to epidural analgesia in patients undergoing open radical or partial nephrectomy. We also hypothesize that the intrathecal opioid administration is associated with a lower incidence of adverse effects compared to epidural analgesia and shorter ICU length of stay.",[71,72,73],"Pain","Renal Cancer","Surgical Procedure, Unspecified",[75,76,77],"Pain management","open nephrectomy","renal cell carcinoma","RECRUITING","2025-03-05",{"date":81,"type":48},"2025-03-10",{"date":83,"type":48},"2025-01-15",{"date":85,"type":20},"2025-12-31",{"name":54,"class":55},""]