[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University School of Physical Education, Krakow, Poland\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":128},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,68,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100602364","pulmonary-rehabilitation-in-salt-chambers-for-patients-with-copd-100602364",false,"NCT07122544","Pulmonary Rehabilitation in Salt Chambers for Patients With COPD","The Impact of Pulmonary Rehabilitation Conducted in Therapeutic Salt Chambers on the Clinical Status of Patients With Chronic Obstructive Pulmonary Disease (COPD)","Inclusion Criteria:\n\n* COPD diagnosis confirmed by a pulmonology specialist according to the 2025 GOLD guidelines.\n* FEV1 ≥ 30% of the predicted value.\n* FEV1\u002FFVC \\\u003C 0.7 after bronchodilator administration in spirometry.\n* Negative bronchodilator reversibility test.\n* Voluntary written consent to participate in the study.\n\nExclusion Criteria:\n\n* COPD exacerbation.\n* Active cancer or a history of cancer within the past five years.\n* Musculoskeletal disorders preventing independent movement and participation in exercise tests and training included in the study protocol.\n* Recent (within six months) surgical procedure or trauma to the chest, abdomen, skull, brain, or eye area.\n* Severe valvular heart disease.\n* Implanted cardioverter-defibrillator.\n* Diagnosed arrhythmias posing a risk of loss of consciousness.\n* Acute coronary artery disease.\n* Epilepsy.\n* Uncontrolled arterial hypertension despite medication.\n* Primary or secondary immunodeficiencies.\n* Respiratory failure requiring chronic or intermittent oxygen therapy.\n* Infectious diseases with fever during the experiment or within two weeks before the study.\n* Claustrophobia.\n* Pregnancy.\n* Simultaneous participation in another rehabilitation program.\n* Significant changes in pharmacological treatment during the study.","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","Title: The Impact of Pulmonary Rehabilitation Conducted in Therapeutic Salt Chambers on the Clinical Condition of Patients with Chronic Obstructive Pulmonary Disease\n\nBackground and Rationale:\n\nChronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder that significantly reduces patients' quality of life and functional capacity. In the search for supportive therapeutic strategies, there is growing interest in unconventional therapeutic environments such as therapeutic salt chambers. The underground climate of the \"Wieliczka\" Salt Mine in Poland - characterized by humidity 60-75%, temperature 12.9-14.5°C, high air purity and ionization - has shown therapeutic potential. However, the clinical effects of pulmonary rehabilitation conducted in such an environment in COPD patients remain insufficiently documented.\n\nStudy Objective:\n\nTo evaluate the effect of pulmonary rehabilitation and climatic therapy conducted in underground salt chambers on the clinical condition of patients with stable COPD.\n\nResearch Question:\n\nDoes pulmonary rehabilitation conducted in a subterranean salt mine environment offer measurable clinical benefits compared to standard surface-based rehabilitation?\n\nStudy Design and Methods:\n\nThis is a randomized, controlled, four-arm interventional study including 80 adult patients with a confirmed diagnosis of COPD according to the GOLD 2025 criteria. Participants will be randomly assigned to one of four groups:\n\nGroup A: Pulmonary rehabilitation in underground therapeutic salt chambers (physical training + microclimate exposure).\n\nGroup B: Pulmonary rehabilitation in a surface-level gymnasium (physical training without microclimate exposure).\n\nGroup C: Passive stay in underground salt chambers (microclimate exposure without physical training).\n\nGroup D: Health education only (control group, surface level).\n\nThe intervention program consists of 16 consecutive working days of 3-hour daily sessions. The content of the rehabilitation varies depending on the assigned group and includes general conditioning exercises, respiratory exercises, relaxation training, and health education.\n\nOutcome Measures and Assessment Tools:\n\nClinical assessments will be conducted at three time points: prior to the intervention (T0), immediately after the intervention (T1), and at a 3-month follow-up (T2 - for Groups A and B only). The monitored variables include:\n\nExercise Tolerance: Incremental Shuttle Walk Test (ISWT)\n\nHealth-Related Quality of Life: St. George's Respiratory Questionnaire\n\nCOPD Symptoms and Risk Indexes: COPD Assessment Test (CAT), BODE Index\n\nMuscle Strength: Deadlift test, hand dynamometer, 30-second Chair Stand Test\n\nRespiratory Muscle Strength: Maximal Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP)\n\nBody Composition: Bioelectrical Impedance Analysis (BIA)\n\nDyspnea Scales: Borg Scale, modified Medical Research Council (mMRC) scale\n\nChest Mobility: Measuring tape assessment\n\nThe study is designed to evaluate both the immediate and long-term effects of different pulmonary rehabilitation models on clinical outcomes in COPD patients, with a focus on whether the underground environment enhances rehabilitation efficacy.",[26],"COPD (Chronic Obstructive Pulmonary Disease)",[28],"speleotherapy","RECRUITING","2025-11-25",{"date":32,"type":33},"2025-11-26","ACTUAL",{"date":35,"type":33},"2025-09-01",{"date":37,"type":20},"2028-01-01",{"name":39,"class":40},"University School of Physical Education, Krakow, Poland","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":41},"100589224","effects-of-pulmonary-rehabilitation-in-salt-chambers-on-functional-efficiency-respiratory-parameters-and-blood-rheology-in-elderly-with-respiratory-diseases-100589224","NCT06951633","Effects of Pulmonary Rehabilitation in Salt Chambers on Functional Efficiency, Respiratory Parameters, and Blood Rheology in Elderly With Respiratory Diseases.","Functional Efficiency, Respiratory Parameters and Blood Rheological Tests in Elderly People With Respiratory Diseases Participating in Pulmonary Rehabilitation in Underground Salt Chambers - a Prospective Experimental Study, Controlled in a Crossover Design","PRSC-FERPBR","Inclusion Criteria:\n\n* people aged 65 and older with chronic respiratory diseases in a stable period of the disease (without exacerbations), qualified to participate in a rehabilitation and treatment stay in the underground Health Resort 'Wieliczka' Salt Mine in Wieliczka,\n* patients who gave informed, written consent to participate in the study.\n\nExclusion Criteria:\n\n* patients with contraindications to subterraneotherapy and physical exercise,\n* lack of written consent to participate in the study,\n* deterioration of health during the implementation of the program.","65 Years",{"count":52,"type":20},33,[23],"The aim of the study is to assess the impact of the rehabilitation and treatment stay at the underground Health Resort of the 'Wieliczka' Salt Mine in Wieliczka on the functional capacity, respiratory parameters, and rheological properties of blood in elderly individuals with respiratory diseases.",[56,57],"the Elderly","Respiratory Disorders",[59],"Pulmonary function, speleotherapy, blood tests, 6MWT, chest","2025-04-22",{"date":62,"type":33},"2025-04-30",{"date":64,"type":33},"2025-04-04",{"date":66,"type":20},"2026-02-28",{"name":39,"class":40},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},"100533465","effects-of-normobaric-hypoxia-exercise-program-on-bone-turnover-markers-and-metabolism-in-premenopausal-women-100533465","NCT06226168","Effects of Normobaric Hypoxia Exercise Program on Bone Turnover Markers and Metabolism in Premenopausal Women","Effect of the Author's Training Program in Normobaric Hypoxia on Changes in Bone Turnover Markers and Carbohydrate and Lipid Metabolism in Premenopausal Women","Inclusion Criteria:\n\n* No significant cardiovascular, respiratory system diseases and musculoskeletal system,\n* No contraindications to physical activity. ECG, baseline urinalysis, morphology are required.\n* T-score within normal limits (+1.0 to -1.0).\n* Informed consent of the patient to participate in the study.\n\nExclusion Criteria:\n\n* Use of hormone replacement therapy (HRT).\n* Use of substances (cigarettes, alcohol).\n* Any training (including hypoxia training or exposure) performed in the 6 months prior to the beginning of the intervention\n* Any other factors determined by the study investigators as unsuitable for participation.",true,"FEMALE","50 Years","59 Years",{"count":80,"type":20},60,[23],"The impact of a proprietary training program in normobaric hypoxia on changes in bone turnover markers as well as carbohydrate and lipid metabolism in premenopausal women falls within the realm of physical culture for an active and healthy society. Within this context, the implementation of a project is supported aiming to:\n\n1. Monitor, support, and promote physical development, fitness, and physical activity in society, by assessing the effects of a proprietary training program in normobaric hypoxia on changes in bone turnover markers as well as carbohydrate and lipid metabolism in premenopausal women.\n2. Develop and implement innovative methods, forms, and means of physical activation and training for individuals of various ages, by formulating general assumptions of an endurance-strength training concept under normobaric hypoxia conditions, concerning changes in bone turnover markers as well as carbohydrate and lipid metabolism in premenopausal women.\n3. Prevent injuries in physical education and sports, by designing a useful training program for osteoporosis prevention as well as for managing carbohydrate and lipid metabolism disorders in premenopausal women.",[84],"Hypoxia",[86,87,88,89],"bone turnover","carbohydrate metabolism","lipid metabolism","normobaric hypoxia","2024-05-07",{"date":92,"type":33},"2024-05-08",{"date":90,"type":33},{"date":95,"type":20},"2026-12",{"name":39,"class":40},2,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":75,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":21,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":127,"locationsCount":41},"100531817","the-impact-of-physical-training-under-normobaric-hypoxia-on-oxidative-stress-level-inflammatory-state-intestinal-damage-and-mitochondrial-metabolism-in-young-males-100531817","NCT06204731","The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males","The Influence of Physical Training in Normobaric Hypoxia on Prooxidant-Antioxidant Imbalance, Inflammatory Marker Levels, Intestinal Damage Degree, and Mitochondrial Energy Release Rate in Young Non-trained Males","Inclusion Criteria:\n\n* no known metabolic diseases, no contraindications to physical exercise and no history of high altitude sickness stated in interview. A medical examination (including ECG, blood and urine tests) is required.\n\nExclusion Criteria:\n\n* changes in diet during the experiment, smoking and abuse of alcohol and\u002For other stimulants.","MALE","19 Years","29 Years",{"count":109,"type":20},50,[23],"* Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal damage, and mitochondrial energy production rate in young sedentary males.\n* Applied objective: Development of practical training guidelines utilizing training in normobaric hypoxia conditions to enhance mechanisms related to oxygen transport, adaptive changes within the immune system, body's antioxidant capacity, gut permeability, substrate utilization efficiency, and mitochondrial function for coaches and athletes.",[113],"Hypoxia, Altitude",[115,116,117,118,119,89,120],"inflammation","oxidative stress","intestinal damage","muscle damage","mitochondrial metabolism","training","2024-01-03",{"date":123,"type":33},"2024-01-12",{"date":125,"type":33},"2023-02-01",{"date":95,"type":20},{"name":39,"class":40},""]