[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University Tunis El Manar\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":240},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,44,84,111,136,159,190,211],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100607587","phase-4-ginger-to-prevent-nausea-and-vomiting-after-laparoscopic-cholecystectomy-100607587",false,"NCT07190495","Ginger to Prevent Nausea and Vomiting After Laparoscopic Cholecystectomy","Preoperative Ginger for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy: A Double-Blind Randomized Controlled Trial","GINGER-PONV","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to ginger\n* Documented history of bleeding disorders or current treatment with anticoagulant agents\n* History of severe postoperative nausea and vomiting or an Apfel score of 4\n* Administration of antiemetic drugs or corticosteroids during the preoperative period\n* Pregnancy or breastfeeding\n* Active gastrointestinal or liver disease","ALL","18 Years",{"count":20,"type":21},102,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This study aims to evaluate whether preoperative oral administration of ginger (800 mg, given 2 hours before surgery) reduces the incidence and severity of postoperative nausea and vomiting (PONV) within the first 24 hours after laparoscopic cholecystectomy.",[27,28],"Postoperative Nausea and Vomiting","Laparoscopic Cholecystectomy",[30,27,28],"Ginger","RECRUITING","2026-04-27",{"date":34,"type":35},"2026-04-28","ACTUAL",{"date":37,"type":35},"2025-07-05",{"date":39,"type":21},"2026-12",{"name":41,"class":42},"University Tunis El Manar","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":43},"100628924","impact-of-date-consumption-on-metabolic-control-and-oxidative-stress-in-patients-with-type-2-diabetes-100628924","NCT07467967","Impact of Date Consumption on Metabolic Control and Oxidative Stress in Patients With Type 2 Diabetes","Inclusion Criteria:\n\n* Age 18-65 years\n* Type 2 diabetes diagnosed for at least one year\n* Well-controlled diabetes on oral antidiabetic drugs for at least 3 months, with a target baseline HbA1c \\\u003C 8%\n* Duration of diabetes \\\u003C 15 years\n* Patient available for an 8-week period\n* Written informed consent\n\nNon-inclusion Criteria:\n\n* Patients on insulin therapy\n* Oral antidiabetic treatment modified within the 3 months prior to inclusion\n* Diabetes with established microvascular or macrovascular complications\n* Severe intercurrent diseases (severe renal insufficiency, severe liver disease, cardiovascular history, neoplasia, inflammatory disease)\n* Pregnancy or breastfeeding\n* Known allergy or intolerance to dates\n* Dietary regimens incompatible with isocaloric substitution (e.g., strict ketogenic diet, prolonged fasting)\n* Inability to understand or comply with study instructions (cognitive impairment, language barrier without interpreter, major logistical constraints)\n\nExclusion Criteria:\n\n* Initiation of insulin therapy or major modification of antidiabetic treatment\n* Occurrence of pregnancy during the study\n* Development of a serious adverse event attributable to the intervention (e.g., persistent hyperglycemia, acute metabolic complications)\n* Patient refusal to continue the study or withdrawal of informed consent\n* Major non-adherence to the intervention (\\\u003C80% of planned intake or absence of isocaloric substitution)\n* Detection of a severe intercurrent condition requiring discontinuation of the intervention (e.g., heart failure decompensation, severe infection)\n* Loss to follow-up preventing the assessment of primary endpoints","65 Years",{"count":52,"type":21},130,[54],"NA","Summary\n\nDates, rich in simple sugars, fiber, and antioxidant polyphenols, have a variable glycemic index and conflicting reported effects on type 2 diabetes. Moderate consumption might raise glycemia if added to the usual diet, but could improve insulin sensitivity and oxidative balance if used as an isocaloric substitute.\n\nThis prospective, interventional, single-center study (Endocrinology Department., La Rabta Hospital, Tunis) aims to evaluate the effect of daily consumption of 3 Deglet Nour dates for 8 weeks on glycemic control and oxidative stress in 130 well-controlled type 2 diabetic patients.\n\nPrimary objectives:\n\nAssess changes in HbA1c, fasting glucose, and HOMA-IR. Measure variations in oxidative stress markers (MDA, SOD, TAC, pentosidine).\n\nSecondary objectives:\n\nMonitor changes in weight, BMI, waist circumference, and blood pressure. Assess tolerance, adherence, satisfaction, and adverse events.\n\nStudy design:\n\nBaseline and final visits (week 0 and week 8) with clinical, dietary, and laboratory assessments.\n\nIsocaloric substitution: 3 dates replace a carbohydrate portion (e.g., fruit or dessert).\n\nNo change in antidiabetic therapy or lifestyle allowed.\n\nEndpoints:\n\nPrimary: ΔHbA1c, Δfasting glucose, ΔHOMA-IR, and oxidative markers. Secondary: Anthropometrics, blood pressure, safety, adherence, lipid and metabolic parameters.\n\nExpected outcome: determine whether moderate, isocaloric date consumption is safe and potentially beneficial for metabolic control and oxidative balance in Tunisian patients with type 2 diabetes.",[57],"Diabete Type 2",[59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74],"Dates (Phoenix dactylifera)","Antioxidants","Polyphenols","Oxidative Stress","Diabetes Mellitus, Type 2","Blood Glucose","Glycated Hemoglobin A (HbA1c)","Insulin Resistance","Metabolic Control","Body Mass Index","Waist Circumference","Blood Pressure","Lipid Profile","Prospective Studies","Nutritional Status","Dietary Intervention","NOT_YET_RECRUITING","2026-03-08",{"date":78,"type":35},"2026-03-12",{"date":80,"type":21},"2026-07-15",{"date":82,"type":21},"2027-12-31",{"name":41,"class":42},{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100617048","prevention-of-rebound-pain-after-axillary-block-100617048","NCT07313553","Prevention of Rebound Pain After Axillary Block","The Effect of Perineural Dexamethasone on Preventing Rebound Pain After Axillary Plexus Block in Hand Surgery","Inclusion Criteria:\n\n* • Age between 18 and 75 years old.\n\n  * Patients are current for hand surgery under axillary plexus block.\n  * Patients classified ASA physical status I, II and III\n\nExclusion Criteria:\n\n* \\- Contraindication to regional anesthesia.\n* Patient's disapproval.\n* Impaired cognition.\n* Patients whose surgery must be done under general anesthesia (complex hand surgery or association of other)\n* Allergy to paracetamol, dexamethasone or opioids","75 Years",{"count":93,"type":21},60,[54],"This will be a single-center randomized double blind placebo control clinical trial. In the cohort of patients undergoing hand surgery under axillary nerve block, participants are recruited from those who are willing to consent and participate in the study, and will be randomly 1:1 divided into intervention group and placebo group.",[97,98],"Pain","Postoperative Care",[100,101,102],"axillary nerve block","dexamethesone","rebound pain","2025-12-17",{"date":105,"type":35},"2026-01-02",{"date":107,"type":21},"2026-01-12",{"date":109,"type":21},"2026-09-30",{"name":41,"class":42},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":43},"100611467","lumbal-erector-spinae-plane-block-for-pain-management-after-total-hip-arthroplasty-100611467","NCT07240961","Lumbal Erector Spinae Plane Block for Pain Management After Total Hip Arthroplasty","Ultrasound-Guided Lumbal Erector Spinae Plane Block on Postoperative Pain Management After Total Hip Arthroplasty","Inclusion Criteria:\n\n* primary total hip arthroplasty with lateral approach and under general anesthesia .\n\nExclusion Criteria:\n\n* • Contraindication or refusal to regional anesthesia\n\n  * Contraindication to non-steroidal anti-inflammatory (NSAID's)\n  * Allergy to opioids\n  * Allergy to paracetamol\n  * Creatinine clearance \\\u003C 30ml\u002Fmin\n  * Weight\\\u003C50 kg or \\>100kg\n  * Psychiatric disorders and difficulty of communication\n  * Lower limb neurological deficit\n  * Patients undergoing bilateral or revision total hip replacement","85 Years",{"count":93,"type":21},[54],"The Erector Spinae Plane (ESP) block or spinal erector block was first described in September 2016 by a Canadian team. It's a block that was initially used for the treatment of chronic thoracic neuropathic pain. The ESP block is one of the inter-fascicular blocks and it's an easy-to-perform technique.In the literature, it has been reported that Lumbar ESPB provides effective analgesia after a hip surgery.\n\nThe purpose of this prospective randomized study was to compare the analgesic effects of the ultrasound-guided lumbar Erector Spinae Plane block on postoperative pain management versus the multimodal analgesia after total hip arthroplasty.",[123],"Total Hip Arthroplasty (THA)",[125,126,127],"hip arthroplasty","Lumbal Erector Spinae Plane Block","pain managment","2025-11-16",{"date":130,"type":35},"2025-11-21",{"date":132,"type":35},"2025-11-01",{"date":134,"type":21},"2026-07-07",{"name":41,"class":42},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":43},"100537025","comparison-of-intravenous-lidocaine-vs-ketamine-in-colorectal-surgery-100537025","NCT06272461","Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery","The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial","INCLUSION CRITERIA:\n\n* Patients aged 18 or older.\n* American society of anesthesiologists' (ASA) physical status of I-III.\n* Elective open colorectal surgery.\n\nNON INCLUSION CRITERIA:\n\n* Patients with contraindications to lidocaine or ketamine.\n* Corticosteroid therapy within the last 6 months.\n* History of immunosuppressive therapy.\n* History of surgery in the last 3 months.\n* Personal medical history of inflammatory bowel disease.\n* Personal medical history of cardiac arrythmias or conduction disorders.\n* Alcohol or drug abuse.\n* Chronic use of opioids or benzodiazepines.\n\nEXCLUSION CRITERIA:\n\n* Severe intraoperative complications.\n* Duration of surgery longer than 5 hours.","90 Years",{"count":145,"type":21},50,[54],"Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).\n\nFor the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours.\n\nFor the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours.\n\nPlasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.",[149,150],"Colorectal (Colon or Rectal) Cancer","Inflammation","2025-11-15",{"date":153,"type":35},"2025-11-18",{"date":155,"type":35},"2023-10-01",{"date":157,"type":21},"2026-03-30",{"name":41,"class":42},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":166,"sex":167,"minAge":18,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":22,"phases":171,"briefSummary":172,"conditions":173,"keywords":176,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":43},"100603673","music-therapy-for-labor-pain-and-anxiety-100603673","NCT07139574","Music Therapy for Labor Pain and Anxiety","Impact of Music Therapy on Labor Pain and Anxiety: A Randomized Controlled Trial in Tunisian Women","Inclusion Criteria:\n\n* Married Tunisian women with a singleton, low-risk pregnancy.\n* Admitted in the latent phase of spontaneous labor, as diagnosed by a midwife or resident.\n* Planned vaginal delivery.\n* Parity \\\u003C 4.\n* Gestational age between 37 and 41 weeks of amenorrhea.\n* Attended at least 4 prenatal consultations.\n* Normal physical and mental health status.\n* No known fetal anomalies.\n* Estimated fetal weight between 2500-4000 g.\n* Cephalic presentation.\n* Normal fetal heart rate and uterine contraction tracings.\n* Able to read, write, and understand study-related information.\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* Women who received epidural analgesia during labor.\n* Presence of auricular malformations.\n* Difficulty in understanding or completing the VAS or STAI-Y assessments.\n* Serious medical or psychiatric disorders.\n* Multiple gestation or pregnancies requiring immediate intervention.\n* Preterm (\\\u003C37 weeks) or post-term (\\>41 weeks) pregnancies.\n* Premature rupture of membranes.\n* Clinical chorioamnionitis or other infections (including HIV).\n* History of severe obstetric complications (e.g., cephalopelvic disproportion, intrauterine fetal death )",true,"FEMALE","45 Years",{"count":170,"type":21},70,[54],"This multicenter randomized controlled trial evaluates the effectiveness of music therapy in reducing pain and anxiety during the latent and active phases of labor in Tunisian women. Participants are randomized to receive either music therapy or standard care. Primary outcomes are pain (VAS) and anxiety (STAI-Y). Secondary outcomes include labor duration, maternal and fetal vital signs, neonatal outcomes, and maternal satisfaction.",[174,175],"Labor Pain","Anxiety",[177,178,179,180,181],"music therapy","anxiety","pain management","labor","randomized controlled trial","2025-08-17",{"date":184,"type":35},"2025-08-24",{"date":186,"type":21},"2025-09",{"date":188,"type":21},"2025-11",{"name":41,"class":42},{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":43},"100573032","ultrasound-guided-midline-vs-landmark-paramedian-continous-spinal-anesthesia-in-the-elderly-100573032","NCT06740994","Ultrasound Guided Midline vs Landmark Paramedian Continous Spinal Anesthesia in the Elderly","Ultrasound Guided Midline Continuous Spinal Anesthesia in the Elderly : is There an Advantage Over Conventional Landmark Paramedian Technique: a Randomized Controlled Trial","Inclusion Criteria:\n\n* all consented patients aged over 65 years old scheduled to undergo surgery for hip fracture under continuous spinal anesthesia with American Society of Anesthesiologists ASA physical status classification from I to III\n\nExclusion Criteria:\n\n* contraindications to spinal anesthesia ( allergy to local anesthetic, coagulopathy, infection at the site of injection)\n* previous history of lumbar spine surgery\n* per operative severe complication with conversion to general anesthesia",{"count":198,"type":21},110,[54],"Former clinical studies have reported the superiority of the landmark guided paramedian approach above the classical landmark guided midline approach for the continuous spinal anesthesia especially in the elderly. On the other hand, more recent clinical trials have suggested that the use of ultrasound to guide spinal anesthesia will be safer and more effective than the conventional palpation-guided technique.\n\nThe aim of this study will be to compare the conventional \"blind\" landmark paramedian approach to the ultrasound \"modern\" guided midline approach for the continuous spinal anesthesia in the elderly with hip fractures.\n\nPatients will randomly divided into two groups:\n\nGroup(PML): will undergo conventional landmark guided paramedian continuous spinal anesthesia Group (MUS): will undergo ultrasound guided midline continuous spinal anesthesia",[202],"Spinal Anesthesia","2024-12-17",{"date":205,"type":35},"2024-12-18",{"date":207,"type":35},"2024-04-29",{"date":209,"type":21},"2025-08-31",{"name":41,"class":42},{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":221,"phases":4,"briefSummary":222,"conditions":223,"keywords":227,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":4},"100556886","diagnostic-interest-of-the-buccal-schirmer-test-in-xerostomia-during-sjgrens-syndrome-xerodiag-100556886","NCT06530940","Diagnostic Interest of the Buccal Schirmer Test in Xerostomia During Sjögren's Syndrome: XERODIAG","XERODIAG","Inclusion Criteria:\n\n* Included patients meet the following criteria:\n* age over 18 years\n* diagnosis of Sjogren's syndrome meeting the ACR\u002FEULAR 2016 criteria.\n\nExclusion Criteria:\n\n* These include:\n* Cognitive or dementia disorders\n* Pregnancy","100 Years",{"count":220,"type":21},180,"OBSERVATIONAL","Xerostomia is a common and very bothersome manifestation that impairs the quality of life in Sjogren's syndrome. Its diagnosis mainly relies on the measurement of salivary flow (SF). Performing this test is unpleasant for the patient, lacks precision, can be influenced by certain conditions, and requires good patient cooperation. Other alternatives such as the buccal Schirmer test can be used. The aim of this study is to demonstrate the non-inferiority of the buccal Schirmer test compared to SF measurement. This is a diagnostic study comparing a group of patients (n=90) with Sjogren's syndrome (SS) and normal SF (≥0.1 ml\u002Fminute) to a group of patients with SS and decreased SF (\\\u003C0.1 ml\u002Fminute).",[224,225,226],"Sjogren's Syndrome","Xerostomia","Diagnosis",[228,229,230,231],"xerostomia","sjogren's syndrom","salivary flow","oral schirmer test","2024-07-31",{"date":234,"type":35},"2024-08-02",{"date":236,"type":21},"2024-08-19",{"date":238,"type":21},"2024-12-31",{"name":41,"class":42},""]