[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Avignon\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":125},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,66,95],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100586502","study-of-the-effect-of-capsinoid-supplementation-on-brown-adipose-tissue-in-obese-adolescents-100586502",false,"NCT06916208","Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents","ADOBAT","Inclusion Criteria:\n\n* member or beneficiary of a health insurance scheme\n* aged between 11 and 18\n* Body Mass Index Z score corresponding to stage 2 obesity according to the curves of Rolland-Cachera et al., 1991 and an absence of weight loss of more than 5% of the total weight over the last 3 months.\n* effective contraception (in pubescent females)\n\nExclusion Criteria:\n\n* known allergy to capsinoids and\u002For soya\n* inflammatory digestive pathology and\u002For history of digestive tract surgery\n* participation in another study or in a period of exclusion determined by a previous study\n* pregnant, parturient or breastfeeding\n* The holder(s) of parental authority or the adolescent refuse(s) to sign the authorisation or acceptance form, respectively.\n* It proves impossible to provide the adolescent or parental guardian(s) with informed information.","ALL","11 Years","18 Years",{"count":20,"type":21},38,"ESTIMATED","INTERVENTIONAL",[24],"NA","Among the new strategies being considered for the treatment of obesity and its metabolic complications, the activation of brown adipose tissue (BAT) from white adipose tissue looks promising. Interest in the study of BAT has increased over the last 5-10 years in response to the discovery of functional BAT in humans. The BAT is a tissue specialized in regulating energy expenditure by producing heat through the oxidation of fatty acids contained in the multiple lipid droplets of brown adipocytes. This adipose tissue does not play a storage role, but rather an anti-obesogenic one, thanks to its high metabolic and energetic activity.\n\nIn addition to exposure to cold, which is the major physiological inducer of brown adipocytes, it seems that exercise and the intake of \"adrenergic\" foods can activate the TAB and potentially induce a change from white to brown tissue via the production of adrenalin and myokines. Acute and\u002For chronic effects of thermogenic food supplements have been reported on BAT activation and energy metabolism. The most conclusive of these involve the capsinoids found in sweet peppers and chillies. Weight loss also improves BAT activation.\n\nThe BAT has already been identified in children. A decrease in its volume and activity from childhood to adolescence and during puberty has been reported.\n\nThe main objective of this randomized controlled double-blind study is to investigate the effects of capsinoid dietary supplementation on BAT activity in obese adolescents.\n\nOur general working hypothesis is that capsinoid supplementation, combined with dietary management, leads to an increase in BAT activity.",[27,28,29,30],"Obese Adolescents","Exercise","Diet Modification","Dietary Supplement","RECRUITING","2026-04-29",{"date":34,"type":35},"2026-04-30","ACTUAL",{"date":37,"type":35},"2025-03-03",{"date":39,"type":21},"2027-03",{"name":41,"class":42},"University of Avignon","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100564216","exercise-snacks-for-breaking-the-sedentary-lifestyle-and-improving-the-physical-fitness-of-obese-adolescents-100564216","NCT06626295","Exercise-snacks for Breaking the Sedentary Lifestyle and Improving the Physical Fitness of Obese Adolescents?","Exercise-snacks: an Effective Solution for Breaking the Sedentary Lifestyle and Improving the Physical Fitness of Obese Adolescents?","SNACKEX","Inclusion Criteria:\n\n* Body mass index Z-score corresponding to stage 2 obesity,\n* no weight loss of more than 5% of total body weight in the past 3 months,\n* parental consent\n* minor\\'s acceptance\n\nExclusion Criteria:\n\n* Contraindication to physical activity\n* current participation in a clinical trial",{"count":53,"type":21},48,[24],"The management of a person with obesity involves long-term behavioral changes with a balanced diet in both quantity and quality, along with the adoption of a more active lifestyle: increasing physical activities and reducing sedentary behaviors. The school setting has been identified as a favorable environment for interventions aimed at reducing and interrupting the time adolescents spend sitting and preventing the associated negative health consequences.\n\nRecently, very short (\\< 1 minute) and intense exercises, called 'exercise-snacks,' have been reported to be effective in adults for 1) improving physical fitness over 6 weeks, and 2) improving vascular function and lowering blood glucose levels over a single day. Additionally, in adolescents with diabetes, they have been shown to reduce body fat. This raises the question of whether adding \\'exercise-snack\\' sessions to a multidimensional care program for hospitalized obese adolescents could further improve their physical fitness in the short and medium term.\n\nThe objective of this project is to compare the effects of a traditional multidimensional care program with the addition of 'exercise-snacks' to the same care program without \\'exercise-snacks\\' on the physical fitness, body composition, vascular function, and physical activity and sedentary behaviors of obese children in the short and medium term. Forty-eight obese adolescents will be included. The \\'exercise-snack\\' group will perform six exercise sessions per day for three weeks in addition to the standard care. The control group will receive only the standard care. Assessments of physical fitness, body composition, vascular health, and questionnaires on physical activity, sedentary behavior, and cognitive restraint will be conducted at the beginning and end of the three-week program, as well as 1 and 3 months after the end of the program.",[27,57,28],"Sedentary Time",{"date":59,"type":35},"2026-05-05",{"date":61,"type":35},"2024-09-09",{"date":63,"type":21},"2026-06",{"name":41,"class":42},2,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":16,"minAge":18,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":77,"phases":4,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":65},"100620928","interaction-between-intraventricular-flow-and-cardiac-mechanics-using-3d-echocardiography-in-athletes-and-sedentary-subjects-100620928","NCT07363993","Interaction Between Intraventricular Flow and Cardiac Mechanics Using 3D Echocardiography in Athletes and Sedentary Subjects","CARDIO-3D","Inclusion criteria for athletes:\n\n\\- Athlete practicing at least 10 hours of endurance training per week for a minimum of 5 years.\n\nInclusion criteria for controls:\n\n\\- Individual not training in more than 3 hours of physical activity per week.\n\nExclusion Criteria for both groups:\n\n* History of known heart disease;\n* Current cardiac rhythm disorder;\n* Individual with one or more cardiovascular risk factors (smoking, diabetes, hypertension, body mass index \\> 30 kg\u002Fm²);\n* Individual in a period of relative exclusion in relation to another protocol, or for whom the annual maximum compensation amount of €4,500 has been reached;\n* Individual not affiliated with a social security system, or not benefiting from such a system;\n* Pregnant or breastfeeding woman; patient unable to give informed consent; protected adults; vulnerable persons;\n* Individual deprived of liberty by judicial or administrative decision.\n\nExclusion criteria for athletes:\n\n\\- Use of substances listed on the prohibited substances list of the French Anti-Doping Agency",true,"45 Years",{"count":76,"type":21},160,"OBSERVATIONAL","Exercise-induced cardiac remodeling, known as the \"athlete's heart,\" corresponds to morphological and functional adaptations of the left ventricle in response to prolonged physical training. It is characterized in particular by physiological hypertrophy and improved myocardial function.\n\nIntraventricular blood flow interacts with cardiac mechanics. Regional shape (e.g., sphericity, wall curvature) and myocardial deformations guide flow patterns to create an optimal hemodynamic environment. The interaction between these different parameters in the athlete's heart remains insufficiently explored. In this context, 3D echocardiography makes it possible to combine indices derived from fluid dynamics, regional myocardial function, and cardiac geometry, enabling a comprehensive assessment of cardiac performance.\n\nPrimary and secondary objectives:\n\nIn this context, the aim of this project is to investigate the relationship between intraventricular flow and cardiac mechanics based on combined measurements of intraventricular flow (e.g., vorticity, pressure gradients), regional myocardial function (e.g., myocardial strain), and global\u002Fregional LV geometry (e.g., sphericity, wall curvature) in the athlete's heart. Since these parameters are interdependent, analyzing their interaction through the development of new echocardiographic tools based on 4D assessments will enable a comprehensive evaluation of functional improvements in the athlete's heart.\n\nThe secondary objectives are to analyze the impact of dyssynchrony on intraventricular flow, to evaluate the influence of primary and secondary deformations on intraventricular flow, and to study cardiac function from an energetic perspective using non-invasive reconstruction of pressure-volume loops for cardiac work estimation.\n\nMethodology:\n\nThe study will include 80 endurance athletes (ENT group) and 80 control subjects (CONT group). The main inclusion criteria common to both groups are: men and women aged 18-45 years, with no known heart disease and no cardiovascular risk factors (e.g., body mass index \\> 30 kg\u002Fm², arterial hypertension). Athletes must train at least 10 hours per week for the past 5 years. Control subjects must not engage in more than 3 hours of physical activity per week.\n\nAthletes will be recruited from elite groups of various federations, during local long-distance races, or during clinical evaluations at Montpellier University Hospital (Dr. C. Hédon's department). Control subjects will be recruited in the Avignon area and in the cardiology department of Montpellier University Hospital during routine visits.\n\nEchocardiographic examinations will be performed in the left lateral decubitus position using Vivid systems with 4D probes. 4D and tri-plane acquisitions with color Doppler will allow assessment of cardiac structure and intraventricular flow. Data analysis will be performed using TOMTEC software, and scripts developed in Matlab and RStudio will process information related to shape, mechanical dispersion, and dyssynchrony. Intraventricular hemodynamics will be analyzed in collaboration with the CREATIS laboratory (D. Garcia), particularly through measurements of intraventricular pressure gradients and vorticity indices.",[80],"Athlete Heart",[82,83,84,85,86],"regional myocardial function","intraventricular flow","cardiac geometry","echo-3D","athlete's heart","2026-01-16",{"date":89,"type":35},"2026-01-23",{"date":91,"type":35},"2025-12-01",{"date":93,"type":21},"2027-08-31",{"name":41,"class":42},{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":65},"100613652","intradialytic-exercise-with-blood-flow-restriction-in-hemodialysis-patients-100613652","NCT07269379","Intradialytic Exercise With Blood Flow Restriction in Hemodialysis Patients","Intradialytic Exercise With Blood Flow Restriction by Vascular Occlusion: A New Strategy for Cardioprotection in Hemodialysis Patients","ERO-CARD","Inclusion Criteria:\n\n* Patients aged between 20 and 79 years.\n* Patients on hemodialysis for more than 3 months.\n* No engagement in regular exercise outside of dialysis.\n* No prior exposure to intradialytic exercise within the past six months.\n* No medical contraindications to physical activity.\n* Life expectancy greater than 6 months.\n* Patients with relative good echogenicity\n\nExclusion Criteria:\n\n* Patient is participating in another Category I interventional study, or has participated in another interventional study within the past 3 months\n* The patient is in an exclusion period determined by a previous study\n* The patient is under legal protection or under guardianship or curatorship It turns out to be impossible to give the patient informed information, or the patient refuses to sign the consent\n* Pregnant, parturient or breastfeeding patient\n* Patients with unstable coronary artery disease.\n* Patients with peripheral artery disease (stage III or IV) in the lower limbs.\n* Patients with limb amputation.\n* Patients with musculoskeletal disorders impairing exercise.\n* Presence of a pacemaker, cardiac stimulation device, or implantable cardioverter defibrillator (ICD).\n* History of heart transplant.\n* Patients with uncontrolled hypertension.\n* Refractory anemia.\n* Patients stratified as high risk for deep venous thrombosis","20 Years","79 Years",{"count":106,"type":21},108,[24],"The main objective is to evaluate in hemodialysis patients the effects of two intradialytic rehabilitation programs based on physical exercise, with or without the application of blood flow restriction, on myocardial stunning and morpho-functional cardiac remodelling, compared with usual care (i.e., dialysis without exercise). In addition, the investigators will also assess the acute effects (i.e., a single session for each condition) of physical exercise, with or without blood flow restriction, on myocardial stunning at the end of dialysis.\n\nIn comparison with a conventional exercise program, the combination of physical exercise with blood flow restriction, which synergistically and additively activates intramuscular signalling pathways related to both exercise and ischaemia, is hypothesised to result in:\n\n1. A greater intradialytic cardioprotection, as demonstrated by a greater reduction in myocardial stunning at the end of dialysis (both in acute and chronic applications), with underlying mechanisms involving systemic and neuro-humoral pathways;\n2. Significant improvements in morpho-functional cardiac remodelling, attenuation of arrhythmic disturbances, and enhancement of aerobic capacity, muscle strength, and muscle mass-effects not observed with exercise alone without blood flow restriction, considering the low exercise intensity used in the current rehabilitation program (chronic application only).\n\nThis is a three-arm randomised clinical trial with parallel groups: standard hemodialysis (HD-CONTChro), a rehabilitation program with intradialytic exercise without vascular occlusion (HD-EXChro), and a rehabilitation program with intradialytic exercise with vascular occlusion (HD-BFREChro), with a 1:1:1 allocation ratio.\n\nTo investigate the acute effects of the interventions, all patients will undergo, in a randomized order, one session of each of the three dialysis modalities-standard hemodialysis (HD-CONTacute), hemodialysis with exercise without vascular restriction (HD-EXacute), and hemodialysis with exercise with vascular restriction (HD-BFREacute)-prior to initiation of the chronic phase of the study.",[110],"Dialysis Patients",[112,113,114,115,82,116],"end stage renal disease","hemodialysis","blood flow restriction exercise","intradialytic exercise","hemorheology","2025-12-05",{"date":119,"type":35},"2025-12-08",{"date":121,"type":35},"2025-11-06",{"date":123,"type":21},"2028-10-06",{"name":41,"class":42},""]