[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Baghdad\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":662},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,43,0,25,[9,52,80,102,126,152,174,196,229,250,280,311,334,358,387,406,433,460,487,513,536,559,594,617,639],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100643395","clinical-performance-of-direct-printed-versus-thermoformed-aligners-100643395",false,"NCT07637227","Clinical Performance of Direct-Printed Versus Thermoformed Aligners","Clinical Performance of In-Office Directly Printed Versus Thermoformed Aligners: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Adult patient with an age range of 15-30 with fully erupted all permanent dentitions excluding third molars, and a willingness to participate in the trial.\n2. Angle Class I non-extraction cases, presented with mild crowding or spacing (\\\u003C5 mm) and dental rotation \\\u003C30° .\n3. Good oral hygiene; no active caries\u002Fperiodontal disease, no history of trauma or root resorption.\n\nExclusion Criteria:\n\n1. Pregnancy, smoking, and systemic conditions affecting bone remodeling.\n2. Subject with poor oral hygiene, using simplified oral hygiene index (OHI-S ≥ 3.1 ) (Greene \\& Vermillion, 1963).\n3. Patient with malposed lower second molars (need orthodontic alignment).\n4. Allergy to materials used (resins, plastics, solvents).\n5. History of trauma, root resorption, and dilacerated roots.\n6. Previous extraction or history of previous orthodontic treatment.",true,"ALL","15 Years","30 Years",{"count":22,"type":23},34,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this study is to evaluate and compare the clinical effectiveness of in-office directly 3D-printed clear aligners versus conventional multilayered thermoformed aligners.\n\nThe main question it aims to answer is:\n\nDoes the use of in-office direct-printed shape-memory aligners result in superior clinical effectiveness, compared to established multilayer thermoformed aligner systems?\n\nResearchers will compare a Direct-Printed Aligner (DPA) group using Senertek Clear-A V2 resin to a Thermoformed Aligner (TFA) group using Zendura FLX multilayer sheets to see if the additive manufacturing process improves clinical outcomes and patient satisfaction.\n\nParticipants will:\n\n* Undergo initial records including intraoral digital scans, photos, and a panoramic radiograph for treatment planning.\n* Wear their assigned clear aligners (either direct-printed or thermoformed) for at least 22 hours per day, changing them every 7 days.\n* Attend follow-up appointments every 5 weeks.",[29,30,31],"Angle Class I Malocclusion","Dental Crowding","Tooth Spacing",[33,34,35,36,37,38],"In office aligners","3D printed aligners","Thermoformed Aligners","Tooth movement","Photopolymer Resin","Pain","RECRUITING","2026-06-05",{"date":42,"type":43},"2026-06-09","ACTUAL",{"date":45,"type":23},"2026-06",{"date":47,"type":23},"2027-10",{"name":49,"class":50},"University of Baghdad","OTHER",3,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100642864","orthodontic-treatment-outcomes-of-self-ligating-system-compared-to-clear-aligner-system-100642864","NCT07638397","Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System","Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System : A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Good oral and general health; no systemic conditions affecting bone metabolism or pain perception.\n2. Age range between 16-32 years.\n3. Presence of full permanent dentition except the third molars.\n4. Class I canine and molar relationship moderate crowding in both arches (6-8 mm) requiring fixed orthodontic treatment.\n5. Without previous orthodontic treatment\u002F functional appliances.\n\nExclusion Criteria:\n\n1. Patients will be excluded from enrollment if they have a substantial skeletal discrepancy necessitating orthognathic surgery.\n2. Patient with class Ⅱ , Ⅲ malocclusion.\n3. Patient with external or internal root resorption.\n4. Patients with poor oral hygiene or active periodontal disease.\n5. 90o or more degree of tooth rotation.","16 Years","32 Years",{"count":62,"type":23},42,[26],"This study is a multi-center, prospective, parallel-group randomized controlled trial designed to compare the orthodontic treatment outcomes of a passive self-ligating bracket system (Damon Ultima) versus a clear aligner system. The primary objective is to evaluate and compare the total orthodontic treatment duration between the two systems in patients with Angle Class I malocclusion and moderate crowding. Secondary objectives include assessing alignment efficiency, patient pain perception at multiple time intervals, dental arch dimension changes, root volume loss percentage, and overall treatment quality using the American Board of Orthodontics Objective Grading System (ABO-OGS).",[66,30],"Angle Class I Maloclussion",[68,69],"Damon ultima","clear aligner","NOT_YET_RECRUITING","2026-06-04",{"date":73,"type":43},"2026-06-10",{"date":75,"type":23},"2026-05-15",{"date":77,"type":23},"2028-08-20",{"name":49,"class":50},1,{"id":81,"slug":82,"hasResults":12,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":24,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":79},"100643222","effect-of-medication-adherence-based-digital-intervention-on-fatigue-severity-weight-and-thyroid-hormone-regulation-100643222","NCT07636681","Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation","Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation in Patients With Hypothyroidism: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults (≥18 years) with primary hypothyroidism.\n* On stable levothyroxine therapy for at least 3 months.\n* Able to read, understand study instructions\n* capable of using basic mobile applications\n* poor medication adherence, clinically significant fatigue, documented weight fluctuations and abnormal thyroid hormone\n\nExclusion Criteria:\n\n* Secondary hypothyroidism or recent thyroidectomy\u002Fradioactive iodine therapy.\n* Pregnancy or breastfeeding woman.\n* Severe psychiatric disorders or cognitive impairment\n* significant visual or hearing deficits\n* Serious comorbidities affecting medication adherence (e.g., chronic disease, renal, or hepatic disease).\n* take dietary supplements or medications that interfere with levothyroxine absorption.","18 Years","60 Years",{"count":90,"type":23},80,[26],"1. To evaluate the effect of a medication adherence-based digital intervention on fatigue severity in patients with hypothyroidism.\n2. To assess the effect of a medication adherence-based digital intervention on weight in patients with hypothyroidism.\n3. To investigate the effect of a medication adherence-based digital intervention on thyroid hormone regulation in patients with hypothyroidism.",[94],"Hypothyroidism","2026-06-03",{"date":42,"type":43},{"date":98,"type":23},"2026-06-01",{"date":100,"type":23},"2026-12-30",{"name":49,"class":50},{"id":103,"slug":104,"hasResults":12,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":17,"sex":18,"minAge":87,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":24,"phases":112,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":121,"startDateStruct":122,"completionDateStruct":123,"leadSponsor":125,"locationsCount":4},"100639409","suraa-campaign-for-stroke-awareness-in-primary-health-care-centers-100639409","NCT07578259","SURA'A Campaign for Stroke Awareness in Primary Health Care Centers","\"Effectiveness of a One-Week Multifaceted SURA'A Consultation-Based Campaign on Stroke Awareness and Intention to Seek Help Among Adults in Primary Health Care Centers","SURA'A","Inclusion Criteria\n\nParticipants will be eligible if they:\n\n1. Age\n\n   * Adults aged ≥18 years residing in Diwaniyah.\n2. Residence o Living in Diwaniyah communities for at least 6 academic months prior to the study.\n3. Access to Primary Health Centers (PHCs)\n\n   * Attending in selected primary health centers where the SURA'A campaign will be implemented.\n4. Cognitive ability\n\n   o Able to understand and answer the survey questions in Arabic.\n5. Consent o Willing to provide informed consent to participate in pre- and post- awareness intervention assessments.\n\nAvailability for follow-up\n\no Agree to participate in both baseline (pre-campaign) and follow-up (post-campaign) assessments.\n\nExclusion Criteria\n\nParticipants will be excluded if they:\n\n1. Have a previous confirmed diagnosis of stroke (to avoid bias in baseline awareness).\n2. Severe cognitive impairment\n\n   * Have diagnosed dementia, severe mental illness, or cognitive impairment that prevents reliable responses.\n3. Communication barriers\n\n   o Cannot communicate in Arabic or has severe hearing\u002Fspeech impairment that prevents participation.\n4. Health professionals o Physicians, nurses, paramedics, or students of medical and health colleges (to avoid overestimation of awareness).\n5. Temporary visitors\n\n   o Non-residents or individuals visiting Diwaniyah temporarily.\n6. Refusal or withdrawal o Decline to participate or withdraw at any stage of the study.",{"count":111,"type":23},350,[26],"This study aims to evaluate the effectiveness of a one-week multifaceted Stroke Urgency Recognition, and Action Awareness (SURA'A) consultation-based campaign in increasing stroke awareness and the intention to seek emergency medical help among adults. The research will be conducted at primary health care centers to determine if this specific educational approach can improve the community's response to stroke symptoms.",[115],"Stroke",[117,118,119,120],"Stroke Awareness","Intention to Seek Help","Primary Health Care Centers","Health Campaign",{"date":71,"type":43},{"date":73,"type":23},{"date":124,"type":23},"2027-04-10",{"name":49,"class":50},{"id":127,"slug":128,"hasResults":12,"nctId":129,"briefTitle":130,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":12,"sex":18,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":24,"phases":136,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":79},"100625069","effect-of-toy-nebulizer-versus-distraction-cards-on-childrens-fear-and-parental-satisfaction-during-nebulization-therapy-a-comparative-study-100625069","NCT07417839","(Effect of Toy Nebulizer Versus Distraction Cards on Children's Fear and Parental Satisfaction During Nebulization Therapy: A Comparative Study","Inclusion Criteria:Children aged 3-6 years receiving nebulization therapy for the first time due to acute respiratory conditions (e.g., asthma or bronchitis).\n\n2\\. Presence of at least one parent (preferably the mother) during the procedure who is capable of evaluation and communication in Arabic or Kurdish.\n\n3\\. Children who are alert and able to cooperate (absence of severe pain or any condition preventing basic communication).\n\n4\\. Voluntary written informed consent obtained from the parents and assent from the child (where applicable).\n\n\\-\n\nExclusion Criteria:Prior history of nebulization therapy (to ensure the fear response is not conditioned by past experiences).\n\n2\\. Children with cognitive, neurological, or developmental disabilities, or severe chronic illnesses (e.g., terminal cancer).\n\n3\\. Parental inability to complete fear or satisfaction questionnaires due to disability or illiteracy.\n\n4\\. Refusal to participate by the child or parent, or the presence of emergency conditions requiring immediate life-saving intervention.\n\n\\-","3 Years","6 Years",{"count":135,"type":23},120,[26],"Goal To compare the effectiveness of a toy nebulizer versus distraction cards in reducing fear among children during nebulization therapy while improving parental satisfaction.\n\nAim To evaluate and measure children's fear levels and parents' satisfaction when using toy nebulizers compared to distraction cards in nebulization sessions.\n\nNull hypothesis: (Hᴏ) There is no statistically significant difference in fear levels among children, and parental satisfaction scores in in the toy nebulizer, distraction cards, and control groups.\n\nAlternative hypothesis: (H₁) There is a statistically significant difference in fear levels among children, and parental satisfaction scores in the toy nebulizer, distraction cards, and control groups.",[139],"Fear is a Common Psychological Response Undergoing Medical Procedures,Act From Uncertainty, Anticipation of Pain, Loss of Control, Previous Negative Experiences",[141,142,143],"\"nebulization therapy\"","\"fear\"","\"distraction card\"","2026-05-22",{"date":146,"type":43},"2026-05-27",{"date":148,"type":43},"2026-04-08",{"date":150,"type":23},"2026-08-01",{"name":49,"class":50},{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":17,"sex":160,"minAge":19,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":24,"phases":164,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":173,"locationsCount":4},"100639032","ttm-based-intervention-for-weight-management-among-high-school-female-students-100639032","NCT07604649","TTM-Based Intervention for Weight Management Among High School Female Students","Efficacy of the Transtheoretical Model of Change-Based Intervention on Weight Management Behavior Among High School Female Students: A Randomized Controlled Trial","TTM-WMHSFS-RCT","Inclusion Criteria:\n\n* Female high school students\n* Age 15-19 years\n* Overweight or obese according to Body Mass Index (BMI) criteria\n* Enrolled in high school morning classes\n* Willing to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* Students below high school level (e.g., middle school students)\n* Students with physical disabilities that prevent participation in physical activity\n* Students with chronic medical conditions affecting body weight or study participation","FEMALE","19 Years",{"count":163,"type":23},154,[26],"To examine the efficacy of a Transtheoretical Model (TTM)-based intervention in improving weight management behaviors.\n\n1. To identify if the student age, body mass index (BMI) and socioeconomic status can predict WMB.\n2. To investigate the difference in students' WMB between groups of grade, liven arrangement, socioeconomic class, and BMI.",[167],"Weight Management","2026-05-19",{"date":144,"type":43},{"date":171,"type":23},"2026-10-10",{"date":124,"type":23},{"name":49,"class":50},{"id":175,"slug":176,"hasResults":12,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":24,"phases":184,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":191,"startDateStruct":192,"completionDateStruct":193,"leadSponsor":195,"locationsCount":79},"100638155","development-of-biofunctional-3d-printed-orthodontic-aligners-with-antimicrobial-and-remineralizing-properties-100638155","NCT07603427","Development of Biofunctional 3D-Printed Orthodontic Aligners With Antimicrobial and Remineralizing Properties","Development of Biofunctional 3D Printed Orthodontic Aligners Enriched With Remineralizing and Anti-microbial Agents","3D-BIOALIGN","Inclusion Criteria:\n\n* Extracted human teeth obtained for reasons unrelated to this study (e.g., orthodontic or periodontal indications).\n* Teeth collected after obtaining ethical approval from the Research Ethics Committee.\n* Teeth free from visible cracks, fractures, restorations, or developmental defects.\n\nExclusion Criteria:\n\n* \\- Teeth with caries, restorations, cracks, fractures, or structural defects.\n* Teeth extracted due to pathological conditions affecting enamel or dentin integrity.\n* Teeth with unknown extraction history",{"count":183,"type":23},400,[26],"Clear orthodontic aligners are widely used due to their esthetics and patient comfort; however, prolonged wear may promote biofilm accumulation and enamel demineralization. This laboratory-based (in vitro) study aims to develop and evaluate a novel directly 3D-printed orthodontic aligner resin modified with antimicrobial and remineralizing agents.\n\nThe study will investigate the incorporation of dimethylaminohexadecyl methacrylate (DMAHDM) as an antibacterial agent and amorphous calcium phosphate (ACP) as a remineralizing component into a 3D-printed aligner resin. Modified and unmodified resin specimens will be fabricated and assessed for antimicrobial activity, ion release, and enamel remineralization potential using extracted human teeth.\n\nIn addition, the mechanical and physical properties of the experimental aligner materials, including shape memory behavior, deflection, tensile strength, translucency, and water sorption, will be evaluated to ensure clinical suitability.\n\nThis study does not involve human participants and is conducted entirely in vitro. The findings are expected to contribute to the development of biofunctional orthodontic aligners that actively inhibit bacterial growth and support enamel health without compromising material performance",[187,188,189,190],"Orthodontic Aligner Material","Enamel Demineralization","Dental Biofilm Formation","Clear Aligner Material Properties",{"date":144,"type":43},{"date":98,"type":23},{"date":194,"type":23},"2027-02-01",{"name":49,"class":50},{"id":197,"slug":198,"hasResults":12,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":203,"enrollmentInfo":204,"targetDuration":4,"studyType":24,"phases":206,"briefSummary":207,"conditions":208,"keywords":213,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":228,"locationsCount":51},"100640437","effect-of-different-breathing-techniques-on-dyspnea-and-cardiopulmonary-parameters-among-patients-after-open-heart-surgery-100640437","NCT07591987","Effect of Different Breathing Techniques on Dyspnea and Cardiopulmonary Parameters Among Patients After Open Heart Surgery","Effect of Segmental Breathing Versus Active Cycle Breathing Techniques on Dyspnea and Cardiopulmonary Parameters Among Patients After Open Heart Surgery: Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age 18-75 years.\n* Scheduled for elective open-heart surgery.\n* Can understand instructions and perform Segmental breathing and Active cycle breathing techniques.\n* Stable preoperative hemodynamic condition.\n\nExclusion Criteria:\n\n* Emergency cardiac surgeries.\n* Patients with pre-existing severe pulmonary disease (e.g., COPD, asthma, restrictive lung disease, Atelectasis, and Tuberculosis).\n* Neurological disorders affecting breathing effort.\n* Patients with rib fractures, recent thoracic trauma, or contraindications for coughing maneuvers.\n* Inability to provide informed consent (cognitive impairment, language barrier).","75 Years",{"count":205,"type":23},99,[26],"Open heart surgery is often associated with postoperative pulmonary complications, reduced lung expansion, dyspnea, and impaired cardiopulmonary function. Breathing exercises are commonly used after surgery to improve lung ventilation, enhance oxygenation, and support respiratory recovery. However, limited evidence is available comparing the effectiveness of segmental breathing exercises and active cycle breathing technique (ACBT) in patients after open heart surgery.\n\nThis randomized controlled trial will compare the effects of segmental breathing exercises and ACBT on dyspnea and cardiopulmonary parameters in adults undergoing open heart surgery. Participants will be randomly assigned to either the segmental breathing exercise group, the ACBT group, or the standard care group during the postoperative period following extubation.\n\nCardiopulmonary parameters, including oxygen saturation, respiratory rate, heart rate, and blood pressure, as well as dyspnea severity and postoperative pulmonary complications, will be assessed before and after the interventions.\n\nThe findings of this study may help identify the most effective breathing exercise technique for improving respiratory outcomes, reducing postoperative pulmonary complications, and supporting evidence-based postoperative rehabilitation after cardiac surgery.",[209,210,211,212],"Dyspnea","Cardiopulmonary Dysfunction","Postoperative Respiratory Dysfunction","Coronary Artery Disease",[214,215,216,217,218,219,220,209,221],"Open Heart Surgery","Cardiac Surgery","Breathing Exercises","Segmental Breathing Exercises","Active Cycle Breathing Technique","Postoperative Patients","Adult Patients","Cardiopulmonary Parameters","2026-05-14",{"date":224,"type":43},"2026-05-18",{"date":226,"type":43},"2026-01-02",{"date":171,"type":23},{"name":49,"class":50},{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":235,"eligibilityCriteria":236,"healthyVolunteers":17,"sex":160,"minAge":4,"maxAge":4,"enrollmentInfo":237,"targetDuration":4,"studyType":24,"phases":239,"briefSummary":240,"conditions":241,"keywords":243,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":245,"startDateStruct":246,"completionDateStruct":247,"leadSponsor":249,"locationsCount":4},"100639980","simulation-based-training-on-immediate-newborn-care-100639980","NCT07591974","Simulation-Based Training on Immediate Newborn Care","Effectiveness of Newborn Simulation-Based Training on Self Efficacy and Practices of Midwives in Immediate Newborn Care","SBT-Newborn","Inclusion Criteria:\n\n1. Active work in the delivery room or emergency wards\n2. Direct involvement in labor, delivery, or immediate neonatal care.\n3. Minimum of one year of experience in maternity care\n4. No advanced immediate newborn care training in the past year\n\nExclusion Criteria:\n\n1. Less than one year of maternity care experience\n2. Participation in advanced immediate newborn care courses within the past",{"count":238,"type":23},100,[26],"This study aims to evaluate the effectiveness of simulation-based training on improving self-efficacy and clinical practices of midwives in providing immediate newborn care. It is a quasi-experimental study conducted among midwives working in healthcare settings to assess the impact of training on their knowledge, confidence, and practical performance in newborn care immediately after delivery.",[242],"Newborn Care",[244],"Simulation- based training, midwives, immediate newborn care, self efficacy",{"date":224,"type":43},{"date":98,"type":23},{"date":248,"type":23},"2027-01-31",{"name":49,"class":50},{"id":251,"slug":252,"hasResults":12,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":258,"enrollmentInfo":259,"targetDuration":4,"studyType":24,"phases":261,"briefSummary":262,"conditions":263,"keywords":266,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":277,"leadSponsor":279,"locationsCount":79},"100628920","combined-mirror-therapy-and-soft-robotic-glove-for-hand-recovery-after-stroke-100628920","NCT07467915","Combined Mirror Therapy and Soft Robotic Glove for Hand Recovery After Stroke","Effect of Combining Mirror Therapy With Soft Robotic Glove on Hand Function Recovery in Post-Stroke Hemiplegic Patients: A Randomized Controlled Trial","MT-SRG","Inclusion Criteria:\n\nAdults aged 18-70 years with first-ever ischemic or hemorrhagic stroke confirmed by imaging (CT or MRI)\n\nModerate upper limb motor impairment (Fugl-Meyer Assessment Upper Extremity \\[FMA-UE\\] score 20-50)\n\nAbility to follow simple instructions (Six-Item Cognitive Impairment Test, 6CIT)\n\nAbility to sit independently for at least 30 minutes\n\nMedically stable and cleared to participate in rehabilitation interventions\n\nWillingness to provide informed consent and adhere to the study protocol\n\nExclusion Criteria:\n\nSevere upper limb spasticity (Modified Ashworth Scale ≥ 3)\n\nCognitive or psychiatric disorders interfering with participation\n\nOther neurological or musculoskeletal conditions affecting upper limb function (e.g., Parkinson's disease, multiple sclerosis, fractures)\n\nPrior exposure to intensive Mirror Therapy or Soft Robotic Gloves\n\nVisual impairment that cannot be corrected with glasses or contact lenses\n\nUncontrolled cardiovascular or other medical conditions that would prevent safe participation","70 Years",{"count":260,"type":23},104,[26],"Post-stroke hemiplegia frequently results in impaired upper limb function, which significantly affects independence and quality of life. Various rehabilitation approaches have been developed to improve motor recovery, including mirror therapy and robotic-assisted training. Mirror therapy uses visual feedback to stimulate neural plasticity and enhance motor recovery, while soft robotic gloves assist repetitive hand movements and facilitate functional training.\n\nThis randomized controlled trial aims to investigate the effect of combining mirror therapy with a soft robotic glove on hand function recovery in patients with post-stroke hemiplegia. Participants will be randomly assigned to different intervention groups receiving mirror therapy, soft robotic glove training, combined therapy, or conventional rehabilitation.\n\nThe primary outcome will assess improvement in upper limb motor function using validated clinical assessment tools. Secondary outcomes will evaluate functional hand performance and activities of daily living. The findings of this study may contribute to improving rehabilitation strategies for stroke survivors and provide evidence for integrating innovative rehabilitation technologies into clinical practice.",[115,264,265],"Hemiplegia","Upper Limb Motor Impairment",[267,268,269,270,271,272],"Mirror Therapy","Soft Robotic Glove","Stroke Rehabilitation","Hand Function Recovery","Upper Limb Rehabilitation","Post-Stroke Hemiplegia","2026-05-08",{"date":275,"type":43},"2026-05-13",{"date":148,"type":43},{"date":278,"type":23},"2026-12-17",{"name":49,"class":50},{"id":281,"slug":282,"hasResults":12,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":286,"eligibilityCriteria":287,"healthyVolunteers":12,"sex":18,"minAge":133,"maxAge":87,"enrollmentInfo":288,"targetDuration":4,"studyType":24,"phases":289,"briefSummary":290,"conditions":291,"keywords":294,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":310},"100624107","effect-of-coughing-exercises-versus-incentive-spirometry-on-respiratory-function-and-recovery-in-children-after-cardiac-surgery-100624107","NCT07405333","Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Function and Recovery in Children After Cardiac Surgery.","Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Outcomes and Postoperative Recovery Among Children Undergoing Cardiac Surgery.","CEXIS","Inclusion Crit\n\n* Children aged 6 to 18 years scheduled for elective cardiac surgery.\n* Postoperative extubation within 24 hours and judged clinically stable to begin respiratory therapy.\n* Hemodynamically stable.\n\nExclusion Criteria:\n\n* Pre-existing moderate-to-severe chronic lung disease requiring baseline oxygen therapy.\n* Neuromuscular disorders significantly impairing cough\u002Finspiratory effort.\n* Emergency surgery, ongoing major bleeding.\n* Prolonged mechanical ventilation \\>72 hours or tracheostomy on admission.",{"count":205,"type":23},[26],"This study examines the effects of coughing exercises and incentive spirometry (IS) on lung function and recovery in children who undergo heart surgery. The main goals are to see:\n\nHow coughing exercises and IS affect breathing and lung function after surgery? How these exercises influence overall recovery after surgery? Children who participate will be randomly assigned to one of three groups: coughing exercises, IS, or standard care. Those in the exercise groups will perform their assigned breathing exercises every 3 hours for the first 3 days after surgery. Daily check-ups will be conducted to monitor their progress, lung function, and oxygen levels.\n\nThe study will measure breathing ability, oxygen levels, and recovery milestones to find out which method is most effective in preventing lung complications and helping children recover faster.",[292,211,293],"Congenital Heart Disease (CHD)","Postoperative Recovery After Cardiac Surgery",[295,296,297,298,299,300,301],"Coughing Exercises","Incentive Spirometry","Congenital Heart Disease","Respiratory Function","Recovery","cardiac surgery","pediatric","2026-05-07",{"date":304,"type":43},"2026-05-12",{"date":306,"type":43},"2025-12-07",{"date":308,"type":23},"2026-10-07",{"name":49,"class":50},4,{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":17,"sex":18,"minAge":318,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":24,"phases":322,"briefSummary":323,"conditions":324,"keywords":326,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":331,"completionDateStruct":332,"leadSponsor":333,"locationsCount":79},"100615378","a-novel-remineralizing-self-etch-primer-for-orthodontic-bracket-bonding-100615378","NCT07291830","A Novel Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding","Clinical Effectiveness of a Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Full permanent dentition including incisors, canines, premolars, and molars (excepting 3rd molars;\n* Teeth with sound, non-carious buccal enamel and no pretreatment with chemical agents such as hydrogen peroxide,\n* No previous orthodontic treatment with fixed appliances.\n\nExclusion Criteria:\n\n* Participants unable to give informed consent,\n* Had craniofacial anomalies,\n* Require orthognathic surgery as part of their treatment,\n* Had congenital enamel defects.","12 Years","35 Years",{"count":321,"type":23},45,[26],"This randomized clinical trial aims to evaluate the clinical effectiveness of a remineralizing self-etch primer used for orthodontic bracket bonding. The study compares bonding performance, enamel surface effects, and clinical outcomes between the experimental primer and the conventional bonding protocol,verify the potential remineralization effect, and examine the amount of adhesive remnants left on enamel over a period of 6 months.",[325,188],"White Spot Lesions",[327,328],"Orthodontic Bracket Bonding","Self-Etch Primers","2026-05-01",{"date":302,"type":43},{"date":75,"type":23},{"date":100,"type":23},{"name":49,"class":50},{"id":335,"slug":336,"hasResults":12,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":341,"targetDuration":4,"studyType":24,"phases":343,"briefSummary":344,"conditions":345,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":357},"100617438","comparative-outcomes-of-damon-ultima-vs-pitts-21-pro-bracket-systems-100617438","NCT07318623","Comparative Outcomes of Damon Ultima vs Pitts 21 Pro Bracket Systems","Comparative Evaluation of Treatment Outcomes Between Damon Ultima and Pitts 21 Pro Bracket Systems; A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Presence of full permanent dentition except the third molars.\n2. Class I with moderate crowding requiring fixed appliance therapy and don't need extraction.\n3. Good dental hygiene and periodontal health.\n4. Good general health; no systemic conditions affecting bone metabolism or pain perception.\n5. Normal crown size and shape.\n6. No prior orthodontic treatment.\n7. Patient has a normal level of vitamin D3 in testing (Vit D3 serum level should be \\>30).\n\nExclusion Criteria:\n\n* Severe skeletal discrepancies requiring orthognathic surgery, craniofacial anomalies). Patients with active periodontal disease or medically compromised patients.",{"count":342,"type":23},40,[26],"Title Comparative Evaluation of Treatment Outcomes between Damon Ultima and Pitts 21 Pro Bracket Systems; A Randomized Clinical Trial Abstract Background: The primary advantages of self-ligation brackets include faster archwire removal and ligation, reduced or eliminated need for chairside assistance, secure archwire engagement, and lower bracket-archwire friction, which collectively contribute to a substantial reduction in resistance to sliding and are theorized to enhance the efficiency of initial tooth alignment. This randomized controlled trial (RCT) will be conducted to assess differences in treatment outcomes with these two different self-ligation bracket systems.\n\nSubjects\u002FMaterials and Methods: This randomized clinical trial included 40 participants with full permanent dentition (excluding third molars) exhibiting Angle Class I malocclusion with moderate crowding. Patients who were scheduled to undergo orthodontic treatment were allocated into two groups: Damon Ultima and Pitts 21 Pro. The total treatment duration will be measured in months from the bonding day to the completion of treatment, in addition to the number of visits.\n\nPre-treatment, post-alignment, and post-treatment records were obtained, including intraoral scans (IOS) for assessing alignment efficiency and arch parameters. Periapical radiographs of the upper and lower incisors were taken before and after treatment to measure the amount of root resorption. Treatment outcomes were evaluated using the American Board of Orthodontics (ABO) grading system. Additionally, pain perception and patient treatment perception were assessed.",[346,347,348,349],"Orthodentic Appliances","Orthodontic Pathological Resorption of External Root","Orthodontic Pain","Orthodontic Brackets",{"date":351,"type":43},"2026-05-04",{"date":353,"type":23},"2026-05-31",{"date":355,"type":23},"2028-03",{"name":49,"class":50},2,{"id":359,"slug":360,"hasResults":12,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":364,"eligibilityCriteria":365,"healthyVolunteers":17,"sex":18,"minAge":366,"maxAge":367,"enrollmentInfo":368,"targetDuration":4,"studyType":24,"phases":369,"briefSummary":370,"conditions":371,"keywords":374,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":386,"locationsCount":79},"100620787","clear-orthodontic-expander-versus-hyrax-100620787","NCT07362160","Clear Orthodontic Expander Versus Hyrax","Evaluating the Clinical Performance of a Novel Clear Orthodontic Expander Versus Hyrax: A Randomized Clinical Trial","COE-Hyarx","Inclusion Criteria:\n\n1. Patients' age at the start of treatment will range from 10-14 years.\n2. Unstable unilateral or bilateral posterior crossbite due to maxillary constriction.\n3. The first molars are fully erupted.\n4. Good oral health free from caries and periodontal problems at the start of treatment.\n5. Good general health.\n\nExclusion Criteria:\n\n1. Patients with obvious facial asymmetry.\n2. Patients with orofacial cleft.\n3. Patients with previous orthodontic treatment.\n4. Patients with bad oral habits.\n5. Patients with active periodontal disease.","10 Years","14 Years",{"count":342,"type":23},[26],"This study will be conducted to evaluate the effectiveness of a clear expander fabricated from 2-mm biocompatible polyethylene terephthalate glycol (PETG) thermoforming material integrated with an expansion screw in achieving dental and skeletal expansion in adolescent patients, compared with the conventional Hyrax expander.",[372,373],"Malocclusion","Narrow Maxilla",[375,376,377,378,379],"clear expander","hyrax","clinical trial","adolescent","thermoplastic material","2026-04-17",{"date":382,"type":43},"2026-04-22",{"date":384,"type":43},"2026-02-01",{"date":194,"type":23},{"name":49,"class":50},{"id":388,"slug":389,"hasResults":12,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":319,"enrollmentInfo":394,"targetDuration":4,"studyType":24,"phases":396,"briefSummary":397,"conditions":398,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":79},"100615543","pain-control-during-braces-removal-using-transcutaneous-electrical-nerve-stimulation-and-high-frequency-vibration-100615543","NCT07293975","Pain Control During Braces Removal Using Transcutaneous Electrical Nerve Stimulation and High-Frequency Vibration","Assessment of Transcutaneous Electrical Nerve Stimulation and High-Frequency Vibration for Pain Control During Bracket Debonding: A Clinical Trial Study","Inclusion Criteria:\n\n1. Patients scheduled for fixed orthodontic appliance removal.\n2. Permanent dentition present, including both anterior and posterior teeth.\n3. Age between 15-35 years.\n4. Ability to provide informed consent and comply with study procedures.\n5. General health adequate for routine orthodontic care.\n6. No history of regular or recent medication intake within the preceding 24 hours, including painkillers, corticosteroids, or anti-flu drugs.\n\nExclusion Criteria:\n\n1. Patients with craniofacial anomalies, systemic conditions affecting pain perception, or taking medications influencing nociception.\n2. Teeth with extensive restorations or prostheses that prevent standard bracket debonding.\n3. Patients with known allergy or contraindication to TENS or vibration devices.\n4. Pregnant women.\n5. Active periodontal disease, including gingival recession or tooth mobility exceeding Grade I.\n6. Excessive gingival overgrowth that may impede debonding or influence study outcomes.",{"count":395,"type":23},90,[26],"This study aims to find the best method to reduce pain during braces removal. We are comparing transcutaneous electrical nerve stimulation (TENS), high-frequency vibration, and a control group with no additional intervention.\n\nPeople who have completed orthodontic treatment and need their braces removed can take part. Participants will be randomly assigned to one of the three groups. The vibration device will be applied during the braces removal, while TENS will be applied just before the procedure.\n\nBefore the procedure, participants' anxiety will be measured using the Modified Dental Anxiety Scale (MDAS). During and after the procedure, pain will be assessed using a Visual Analog Scale (VAS) from 0 to 100, and participants will rate their satisfaction using a Numerical Rating Scale (NRS) from 0 to 10.\n\nThe purpose of this research is to help orthodontists identify the method that makes braces removal less uncomfortable, more tolerable, and more satisfying for patients.",[348],{"date":400,"type":43},"2026-04-20",{"date":402,"type":43},"2026-01-01",{"date":404,"type":23},"2026-09",{"name":49,"class":50},{"id":407,"slug":408,"hasResults":12,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":4,"eligibilityCriteria":412,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":258,"enrollmentInfo":413,"targetDuration":4,"studyType":24,"phases":414,"briefSummary":415,"conditions":416,"keywords":419,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":79},"100631199","effect-of-local-application-of-1-metformin-gel-on-implant-stability-and-peri-implant-bone-density-a-randomized-controlled-study-100631199","NCT07497568","Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Study","Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* 1\\) Patients age at least 18 years old. 2) Patient with partial edentulous teeth bounded areas that need dental implant for teeth replacement.\n\n  3\\) Adequate bone volume for implant placement (at least 5 mm width - 10 mm height).\n\n  4\\) Ability to tolerate conventional surgical and restorative procedures. 5) Patients who are willing to comply the study and give their consent.\n\nExclusion Criteria:\n\n\\- 1) Active infection or inflammation in the implant zone. 2) Presence of any uncontrolled systemic diseases. 3) Patient with history of chemotherapy or radiotherapy. 4) Patient had undergone bone grafting and soft tissue procedures prior to implant surgery.\n\n5\\) Patient had undergone tooth extraction at the implant site less than 6 months prior to implant surgery.",{"count":22,"type":23},[26],"This randomized controlled clinical study aims to evaluate the effect of local application of 1% metformin gel on implant stability and peri-implant bone density. Patients requiring dental implants will be randomly allocated into two groups: a control group and a test group receiving metformin gel. Implant stability will be assessed using resonance frequency analysis, and bone density will be evaluated using CBCT imaging. The outcomes will be compared over a follow-up period to determine the effectiveness of metformin in enhancing osseointegration",[417,418],"Dental Implant","Stability",[420,421,422,423,424],"dental implant","CBCT","Metformin","bone density","RFA","2026-03-23",{"date":427,"type":43},"2026-03-27",{"date":429,"type":43},"2025-11-01",{"date":431,"type":23},"2027-06-01",{"name":49,"class":50},{"id":434,"slug":435,"hasResults":12,"nctId":436,"briefTitle":437,"officialTitle":438,"acronym":4,"eligibilityCriteria":439,"healthyVolunteers":12,"sex":18,"minAge":367,"maxAge":20,"enrollmentInfo":440,"targetDuration":4,"studyType":24,"phases":442,"briefSummary":443,"conditions":444,"keywords":448,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":457,"leadSponsor":459,"locationsCount":79},"100630684","antiplaque-efficacy-and-patient-reported-outcome-of-chlorohexidine-cetylpyridinium-chloride-and-essential-oil-mouthwashes-in-orthodontic-patients-100630684","NCT07490873","Antiplaque Efficacy and Patient Reported Outcome of Chlorohexidine, Cetylpyridinium Chloride, and Essential Oil Mouthwashes in Orthodontic Patients","Antiplaque Efficacy and Patient Reported Outcome of Chlorohexidine, Cetylpyridinium Chloride, and Essential Oil Mouthwashes in Orthodontic Patients: A Randomized Crossover Clinical Trial","Inclusion Criteria:\n\n* Age 14-30 years.\n* Wearing orthometric-type fixed orthodontic appliances(metallic brackets and archwires) and currently in alignment stage.\n* Able and willing to attend all study visits and comply with study procedures, including washout periods and mouthwash use.\n* Baseline oral status after preparatory phase: plaque index (Löe \\& Silness) ≥ 1.0 and gingival index (Löe \\& Silness) ≥ 0.5.\n* BOP less than 10%.\n* Systemically healthy individuals with no history of antibiotic use or other medications in the preceding 3 months.\n* Willing to refrain from using any other mouthwash or antimicrobial oral hygiene product (except for the assigned study mouthwash and their routine toothpaste) throughout the study.\n* Provide written informed consent (and parental\u002Fguardian consent if under legal age).\n\nExclusion Criteria:\n\n* Periodontitis patients and untreated caries requiring urgent care.\n* Smoking or use of tobacoo\u002Fnicotine products(including vaping).\n* Known allergy or hypersensitivity to CHX, CPC, EO components (thymol, eucalyptol, menthol, methyl salicylate), or any ingredient in the study formulations.\n* Pregnancy or breastfeeding.\n* Use of any antiseptic mouthwash, oral probiotic, or antimicrobial gel in the 3 months prior to baseline.",{"count":441,"type":23},24,[26],"The goal of this clinical trial is to evaluate and compare the antiplaque efficacy and patient reported outcome of three commonly used antiseptic mouthwashes - Chlorhexidine (CHX), Cetylpyridinium Chloride (CPC), and Essential Oil (EO) formulations - in orthodontic patients undergoing fixed appliance therapy. The main question it aims to answer is:\n\nIn orthodontic patients wearing fixed appliances, what is the comparative effect of chlorhexidine, cetylpyridinium chloride, and essential-oil mouthwashes versus placebo on clinical periodontal parameters, salivary IL-1β levels, and patient-reported outcomes.\n\nPrior to enrollment in the clinical trial, all potential participants will undergo a preparatory phase for one month aimed at achieving optimal oral health and minimizing confounding baseline inflammation. During this phase, participants will receive a full professional oral prophylaxis, including scaling and polishing, to remove dental plaque and calculus deposits. This ensures that all individuals begin the study with a comparable level of oral hygiene and gingival health.\n\nParticipants will be instructed on a standardized oral hygiene regimen, including proper toothbrushing technique using a soft-bristled toothbrush and fluoridated toothpaste twice daily. In addition, each participant will be provided with a single-tufted brush as an interproximal cleaning aid to maintain plaque control around orthodontic brackets and hard-to-reach areas. The use of any other mouthwash or adjunctive antimicrobial agent will be prohibited during this phase. After preparatory phase, participants will undergo a four-day plaque-accumulation period immediately prior to baseline clinical and biochemical assessments. During this 4-day period participants will be instructed to refrain from all mechanical oral hygiene procedures (no toothbrushing, interdental cleaning, or mouthrinse use) in order to standardize plaque formation across subjects and create a measurable baseline plaque burden for subsequent comparisons.\n\nAfter that, In base line visit the salivary sample will be collected for IL-1β measurement and clinical periodontal parameters (PI,GI,BOP,PPD) will be measured and receiving oral hygiene instructions and motivation, and first intervention will be given to the patient.\n\nAfter one week Saliva will be collected for IL-1β measurement and the clinical measurements ( PI,GI,BOP)will be taken, then the participant goes into washout period for two weeks, after that the participant will be called to repeat the same protocol for the remaining three interventions.",[445,446,447],"Effectiveness of Chlorohexidine","Effectiveness of Essential Oil","Effectiveness of Cetylpyridinium Chloride",[449,450,451],"Chlorohexidine","Cetylpyridinium chloride","Essential oil","2026-03-18",{"date":454,"type":43},"2026-03-24",{"date":456,"type":43},"2026-01-05",{"date":458,"type":23},"2026-10-01",{"name":49,"class":50},{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":467,"enrollmentInfo":468,"targetDuration":4,"studyType":24,"phases":470,"briefSummary":471,"conditions":472,"keywords":473,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":79},"100618585","hard-tissue-augmentation-with-or-without-connective-tissue-graft-in-immediate-esthetic-implants-100618585","NCT07333534","Hard Tissue Augmentation With or Without Connective Tissue Graft in Immediate Esthetic Implants","Effectiveness of Hard Tissue Augmentation With or Without Connective Tissue Graft Following Immediate Dental Implants in the Esthetic Zone: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients with a non-restorable tooth or a remaining root without signs of acute infection in the maxillary esthetic zone.\n* The failing tooth is an incisor, canine or first bicuspid in the maxilla bounded by natural sound teeth.\n* Sufficient bone (\\>4 mm) apically and palatally to allow for proper implant positioning with sufficient primary stability (≥35 N cm).\n* Sufficient mesial-distal and interocclusal space for placement of the implant and definitive restoration.\n\nExclusion Criteria:\n\n* Patients with systemic conditions affecting bone healing (e.g., uncontrolled diabetes).\n* Teeth with current acute periapical infection.\n* Dehiscence of the labial (facial) bone plate after extraction.\n* Signs of uncontrolled periodontal disease.\n* Heavy smokers and vulnerable groups (pregnant females and decision-impaired individuals).\n* History of head and neck radiation therapy.","65 Years",{"count":469,"type":23},28,[26],"This randomized controlled study is aimed to evaluate the esthetic, clinical, and radiographic outcomes following the placement of immediate single-tooth implant with hard and soft tissue augmentation.\n\nSubjects will randomly assigned to one of two groups:\n\n* Group A (control group) receiving an immediate single-tooth implant in the esthetic zone with bone augmentation only.\n* Group B (study group) receiving an immediate single-tooth implant in the esthetic zone with bone augmentation and connective tissue graft (CTG).\n\nThe main questions it aims to answer is:\n\nIs there is a significant difference in the esthetic outcome between bone augmentation alone and bone augmentation combined with connective tissue graft after immediate dental implant in the esthetic zone?",[417],[474,475,476,477,478],"immediate implant","maxillary esthetic zone","CTG","jumping gap","bone augmentation","2026-03-12",{"date":481,"type":43},"2026-03-13",{"date":483,"type":43},"2025-12-20",{"date":485,"type":23},"2026-07-01",{"name":49,"class":50},{"id":488,"slug":489,"hasResults":12,"nctId":490,"briefTitle":491,"officialTitle":492,"acronym":493,"eligibilityCriteria":494,"healthyVolunteers":12,"sex":18,"minAge":495,"maxAge":88,"enrollmentInfo":496,"targetDuration":4,"studyType":24,"phases":497,"briefSummary":498,"conditions":499,"keywords":501,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":507,"startDateStruct":509,"completionDateStruct":511,"leadSponsor":512,"locationsCount":4},"100628055","effect-of-lavender-aromatherapy-massage-on-pain-and-wrist-mobility-in-rheumatoid-arthritis-100628055","NCT07456657","Effect of Lavender Aromatherapy Massage on Pain and Wrist Mobility in Rheumatoid Arthritis","The Effect of Lavender Aromatherapy Massage on Pain Intensity and Wrist Joint Mobility in Patients With Rheumatoid Arthritis: A Randomized Controlled Trial","LAM-RA","Inclusion Criteria:\n\n* Age 20 to 60 years\n* Diagnosis of rheumatoid arthritis meeting the 2010 ACR\u002FEULAR classification criteria\n* Seropositive for Rheumatoid Factor (RF)\n* Stable dosage of RA medications (NSAIDs, csDMARDs, bDMARDs) for at least 3 months prior to enrollment with commitment to maintain the regimen\n\nExclusion Criteria:\n\n* Acute joint inflammation or infection in the hands or upper back during screening\n* Recent surgery (within 6 months) affecting hands or upper back\n* Dermal lesions, open wounds, infections, or significant vascular pathology at treatment sites\n* Serious comorbidities (uncontrolled diabetes, renal failure, cancer, severe cardiac\u002Frespiratory disease, coagulopathies, anticoagulant use)\n* Pregnancy or breastfeeding\n* Previous lavender aromatherapy massage within 6 months\n* Documented hypersensitivity to lavender aromatherapy massage","20 Years",{"count":238,"type":23},[26],"This randomized controlled trial aims to evaluate the effect of lavender aromatherapy massage on pain intensity and wrist joint mobility in patients with rheumatoid arthritis. Participants will be randomly assigned to receive lavender aromatherapy massage in addition to standard care or standard care alone. Pain intensity and wrist mobility will be measured before and after the intervention period. The findings of this study may provide evidence regarding the effectiveness of complementary therapies in reducing pain and improving joint function in patients with rheumatoid arthritis.",[500],"Rheumatoid Arthritis (RA)",[502,503,504,38,505],"Lavender Aromatherapy","Massage Therapy","Wrist Mobility","Rheumatoid Arthritis","2026-03-06",{"date":508,"type":43},"2026-03-10",{"date":510,"type":23},"2026-04-01",{"date":194,"type":23},{"name":49,"class":50},{"id":514,"slug":515,"hasResults":12,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":4,"eligibilityCriteria":519,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":24,"phases":522,"briefSummary":524,"conditions":525,"keywords":527,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":529,"startDateStruct":531,"completionDateStruct":533,"leadSponsor":535,"locationsCount":79},"100628241","phase-4-radiographical-histomorphometrical-and-biomarker-analysis-after-maxillary-sinus-augmentation-utilizing-xenograft-particulate-bone-graft-mixed-with-parathyroid-hormone-100628241","NCT07459075","Radiographical, Histomorphometrical and Biomarker Analysis After Maxillary Sinus Augmentation Utilizing Xenograft Particulate Bone Graft Mixed With Parathyroid Hormone","Radiographical, Histomorphometrical and Biomarker Analysis After Maxillary Sinus Augmentation Utilizing Xenograft Particulate Bone Graft Mixed With Parathyroid Hormone: A Randomized Controlled Study","Inclusion criteria\n\n* Healthy individuals without any systemic disease\u002Flocal pathological lesion at the sinus zone that compromise the bone healing potential.\n* Fair to good oral hygiene.\n* Patient's age ≥ 18 years.\n* The RBH was 3 mm or less. Atrophic edentulous posterior maxillary ridge (missing tooth or teeth in the sinus zone), with adequate ridge width (≥ 5 mm) to accommodate an average DI diameter and to gain primary implant stability.\n* Healed planned implant insertion site.\n\nExclusion criteria\n\n* Medically compromised patients with any of the following conditions that could interfere with normal healing potential or osseointegration such as uncontrolled diabetes mellitus, currently on chemotherapy, corticosteroid or bisphosphonate, radiotherapy of the head and neck in the past 2 years, bleeding disorders, ongoing pregnancy, thyroid hormones problems and psychiatric disorders.\n* The RBH ˃ 3 mm.\n* Thickness of the SM ˃ 5 mm.\n* Maxillary sinusitis (acute and chronic) or any other pathologies in the MS.\n* Previous MS surgery.\n* Heavy smoking ˃ 20 cigarettes daily and\u002For alcohol abuse.\n* Parafunctional habits such as severe bruxism and clenching.",{"count":521,"type":23},30,[523],"PHASE4","This study aimed the to investigate the beneficial effect of combining PTH with bovine-derived bone graft bone in maxillary sinus augmentation.\n\nThere is limited information available about the effect of PTH on maxillary sinus augmentation to achieve a clear understanding of PTH's efficacy in bone regeneration and bone remodelling through radiological, clinical, biomarker, histological and histomorphometric assessment .\n\nObjectives\n\n1. Evaluation of the bone density at the planned implants sites using cone beam computed tomography (CBCT).\n2. Histomorphometry examination of maxillary sinus bone to measure (bone trabeculae, connective tissue, osteoblast, osteocyte) after healing 4 months after augmentation.\n3. Osteopontin as biomarker analysis for bone regeneration and osteoblast activity.\n4. Evaluate the primary stability of implant in upper posterior area filled with PTH (1 34) and bovine-derived bone graft compared to bovine-derived bone graft alone.",[526],"Maxillary Sinus Augmentation",[528],"bone regeneration; bone grafts; orthopaedics; dental implant, PTH.",{"date":530,"type":43},"2026-03-09",{"date":532,"type":43},"2025-05-01",{"date":534,"type":23},"2026-11",{"name":49,"class":50},{"id":537,"slug":538,"hasResults":12,"nctId":539,"briefTitle":540,"officialTitle":541,"acronym":4,"eligibilityCriteria":542,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":4,"enrollmentInfo":543,"targetDuration":4,"studyType":24,"phases":544,"briefSummary":545,"conditions":546,"keywords":548,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":553,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":558,"locationsCount":79},"100628239","phase-4-effect-of-ibuprofen-on-acute-inflammatory-response-after-one-stage-periodontal-therapy-100628239","NCT07459049","\"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy\"","Efficacy Of Ibuprofen In Reducing Acute Inflammatory Response Following One Stage Non- Surgical Periodontal Therapy (A Randomized Clinical Trial )","Inclusion Criteria:\n\n1. systemically healthy patients.\n2. having a minimum of 20 teeth.\n3. Generalized unstable periodontitis.\n4. Pocket depth \\[≥ 4 mm\\].\n5. All included participants should be adults aged more than 18 years .\n6. smokers and non smokers\n\nExclusion Criteria:\n\n1. Allergy or hypersensitivity to Ibuprofen or other NSAIDs.\n2. current systemic anti-inflammatory or antibiotic therapy (\\\u003C3 months).\n3. peptic ulcer disease.\n4. recent periodontal therapy (\\\u003C3 months).\n5. Asthma.\n6. Renal impairment .\n7. Hepatic impairment.\n8. Severe cardiac disease (heart failure, hypertension (.\n9. Bleeding disorders (e.g., hemophilia) or patients taking anticoagulants .\n10. Any participant who had known or suspected high risk for tuberculosis, hepatitis B or HIV infections.\n11. pregnant or lactating females.\n12. those being unable to provide written informed consent.",{"count":521,"type":23},[523],"The goal of this ( Clinical Trial ) is to evaluate the efficacy of Ibuprofen in reducing acute inflammatory response (hs-CRP, ProCT, IL-6) after one hour and one week following one stage non surgical periodontal therapy.\n\nThe main question it aims to answer is:\n\n\"Does Ibuprofen effectively reduce the acute inflammatory response ( hs-CRP, ProCT, IL-6) following one-stage non-surgical periodontal therapy?\"",[547],"Periodontitis",[549,550,551,552],"Ibuprofen","Acute inflammatory response","One stage periodontal therapy","Non-surgical periodontal therapy",{"date":530,"type":43},{"date":555,"type":43},"2025-12-01",{"date":557,"type":23},"2026-08",{"name":49,"class":50},{"id":560,"slug":561,"hasResults":12,"nctId":562,"briefTitle":563,"officialTitle":564,"acronym":565,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":18,"minAge":567,"maxAge":568,"enrollmentInfo":569,"targetDuration":4,"studyType":24,"phases":571,"briefSummary":572,"conditions":573,"keywords":577,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":589,"startDateStruct":590,"completionDateStruct":591,"leadSponsor":593,"locationsCount":79},"100628319","premature-infant-oral-motor-intervention-vs-pacifier-for-oral-feeding-transition-in-preterm-infants-100628319","NCT07460089","Premature Infant Oral Motor Intervention vs. Pacifier for Oral Feeding Transition in Preterm Infants","The Effect of the Premature Infant Oral Motor Intervention Versus Pacifier Use in the Transition to Oral Feeding in Preterm Infants","PIOMI","Inclusion Criteria:\n\n1. \\- Preterm infants born at 26-32 weeks of gestational age\n2. \\- Clinically stable (no mechanical ventilation, no major congenital anomalies, no necrotizing enterocolitis)\n3. \\- Birth weight ≥1000 grams\n4. \\- Informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n1. Orofacial malformations (e.g., cleft lip, cleft palate)\n2. Neurological impairment affecting sucking ability (e.g., intraventricular hemorrhage grade III or IV, periventricular leukomalacia)\n3. Infants who received any prior structured oral motor intervention\n4. Major congenital anomalies or genetic syndromes affecting feeding or development\n5. Infants requiring surgical interventions during the study period\n6. Lack of parental consent","1 Day","28 Days",{"count":570,"type":23},150,[26],"This study compares three approaches to help premature babies learn to feed by mouth: a special mouth exercise program (called PIOMI), using a pacifier, and standard care. Premature babies often have difficulty feeding because their sucking, swallowing, and breathing are not yet coordinated, which can lead to longer hospital stays. The study will include 150 premature infants born between 26 and 32 weeks of pregnancy at a hospital in Thi Qar. Babies will be randomly placed into one of three groups: one group will receive a many-day mouth exercise program, another will use a pacifier for many days, and the third will receive routine care. We will measure how quickly each baby learns to feed fully by mouth, how long they stay in the hospital, how much weight they gain, and their feeding skills. The results may help improve care for premature babies and reduce the time they spend in the hospital.",[574,575,576],"Feeding Difficulties","Sucking Behavior","Premature",[578,579,580,574,575,565,581,582,583,584,585,586,587,588],"Premature Infant","Preterm Infant","Oral Feeding","Pacifier Use","Non-nutritive Sucking","Oral Motor Intervention","Neonatal Intensive Care","NICU","Feeding Transition","Weight Gain","Length of Hospital Stay",{"date":508,"type":43},{"date":508,"type":23},{"date":592,"type":23},"2026-05-30",{"name":49,"class":50},{"id":595,"slug":596,"hasResults":12,"nctId":597,"briefTitle":598,"officialTitle":599,"acronym":4,"eligibilityCriteria":600,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":4,"enrollmentInfo":601,"targetDuration":4,"studyType":24,"phases":603,"briefSummary":604,"conditions":605,"keywords":606,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":610,"lastUpdatePostDateStruct":611,"startDateStruct":613,"completionDateStruct":615,"leadSponsor":616,"locationsCount":79},"100615001","impact-of-guided-biofilm-therapy-on-epithelial-and-mesenchymal-biomarkers-in-periodontitis-patients-100615001","NCT07286916","Impact of Guided Biofilm Therapy on Epithelial and Mesenchymal Biomarkers in Periodontitis Patients","Impact of Guided Biofilm Therapy on Gingival Crevicular Fluid Epithelial and Mesenchymal Biomarkers in Periodontitis Patients: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Adult subjects (\\>18 years).\n2. Subjects are not currently under active periodontal therapy or joining other trial in the last 3 months.\n3. Patients must be diagnosed with generalized unstable periodontitis with bilateral, symmetrical distribution of PPD ≥ 4mm and positive BOP.\n\n   \\-\n\nExclusion Criteria:\n\n1. Patients not diagnosed with periodontitis.\n2. Patients consuming antibiotics.\n3. Regular users of nonsteroidal anti-inflammatory drugs (NSAIDs).\n4. Patients receiving periodontal treatment 3-months prior to the study.\n5. Pregnant or mothers in a breastfeeding period.\n6. Third molars and teeth with furcation involvement.\n7. Patients taking antioxidant supplements.\n8. Patients with heavy calculus that would prevent PerioPaper strips entrance to the periodontal pocket.\n9. Patient with pulmonary diseases and with a history of allergy to erythritol.\n10. Patients not willing to participate. -",{"count":602,"type":23},18,[26],"The goal of this clinical trial is to investigate the clinical and biochemical effects of the guided biofilm therapy protocol as an alternative to the conventional non-surgical periodontal therapy in patients with periodontitis. The main question it aims to answer is:\n\nDoes the guided biofilm therapy (GBT) protocol have an impact on gingival crevicular fluid (GCF) epithelial and mesenchymal biomarkers in patients with periodontitis?\n\nAll patients will be instructed to brush their teeth twice daily and will be supplied with the same type of toothpaste and toothbrush, with suitable interdental aids. All patients will be instructed to attend again after 7 days.\n\nAt baseline, full-mouth periodontal charting and radiographs will be obtained and after 1-hour, GCF samples will be collected from both test and control groups. Sites allocated to control group will undergo supragingival debridement by using ultrasonic device. After one week, the control group will receive RSD using area specific (Gracey) curettes (Medesy, Italy) according to the 24-hours protocol and will receive teeth polishing by using rubber polishing cups and tooth polishing paste, while the test group will receive a full GBT protocol which includes eight steps: (1) ASSESS, (2) DISCLOSE, (3) MOTIVATE, (4) AIRFLOW, (5) PERIOFLOW, (6) PIEZON PS\\*, (7) CHECK, and (8) RECALL. After finishing the treatment session, the patients will be asked to attend for follow up, clinical evaluation of PI, BOP, PPD, and CAL, and GCF samples collection after 1 month and 3 months.",[547],[607,608,609,547],"Guided biofilm therapy","Gingival crevicular fluid","Epithelial Mesenchymal Transition","2026-02-24",{"date":612,"type":43},"2026-02-27",{"date":614,"type":43},"2026-01-04",{"date":45,"type":23},{"name":49,"class":50},{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":622,"acronym":4,"eligibilityCriteria":623,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":624,"targetDuration":4,"studyType":626,"phases":4,"briefSummary":627,"conditions":628,"keywords":629,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":636,"leadSponsor":638,"locationsCount":79},"100627075","prevalence-of-treponema-parvum-in-subgingival-microbiome-of-patients-with-periodontitis-100627075","NCT07443917","Prevalence of Treponema Parvum in Subgingival Microbiome of Patients With Periodontitis","Prevalence of Treponema Parvum in Subgingival Microbiome of Patients With Periodontitis: A Case-Control Study","Inclusion Criteria: include participants who have at least 20 teeth and diagnosed as generalized periodontitis.\n\nExclusion Criteria: participants meeting any of the following criteria were excluded: (1) undergoing orthodontic treatment; (2) having a history of antibiotic\u002Fnonsteroidal anti-inflammatory drugs use within the last three months; (3) having a history of valve replacement who need prophylactic antibiotic coverage; (4) pregnant or lactating women; (5) having a history periodontal therapy within the last six month.\n\n\\-",{"count":625,"type":23},112,"OBSERVATIONAL","The current study primarily aims to evaluate the presence of T. parvum in periodontal health and disease, and its correlation with clinical parameters. Subgingival plaque samples will be collected using sterile paper points then the samples will be analyzed using quantitative polymerase chain reaction (qPCR) to detect T. parvum and estimate its relative amount in the biofilm. The results may help clarify the association between T. parvum and periodontitis.",[547],[630,631,547],"Treponema parvum","Subgingival microbiome","2026-02-23",{"date":634,"type":43},"2026-03-02",{"date":555,"type":43},{"date":637,"type":23},"2026-09-01",{"name":49,"class":50},{"id":640,"slug":641,"hasResults":12,"nctId":642,"briefTitle":643,"officialTitle":644,"acronym":4,"eligibilityCriteria":645,"healthyVolunteers":12,"sex":18,"minAge":646,"maxAge":318,"enrollmentInfo":647,"targetDuration":4,"studyType":24,"phases":648,"briefSummary":649,"conditions":650,"keywords":652,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":657,"completionDateStruct":659,"leadSponsor":661,"locationsCount":79},"100625070","effect-of-cartoon-projection-and-ball-squeezing-on-pain-during-venipuncture-in-children-100625070","NCT07417852","Effect of Cartoon Projection and Ball Squeezing on Pain During Venipuncture in Children","Effect of Immersive Cartoon Projection and Ball Squeezing on Pain During Venipuncture Among Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged 4-12 years\n* Requiring venipuncture for routine blood testing\n* Able to watch cartoon video during procedure\n* Parental consent obtained\n\nExclusion Criteria:\n\n* Developmental delay preventing cooperation\n* Severe anxiety disorder\n* Visual impairment\n* Non-English\u002FArabic speaking parents","2 Years",{"count":135,"type":23},[26],"The goal of this clinical trial is to learn which distraction method works better to reduce needle pain in children aged 4-12 years during blood draws.\n\nThe main questions it aims to answer are:\n\n* Does watching cartoon videos lower children's pain more than squeezing a stress ball?\n* Which method do parents prefer for their children?\n\n  120 children will be randomly assigned to watch cartoons or squeeze a ball while nurses draw blood. Pain will be measured using a 0-10 pain scale right after the needle.\n\nThis study will help nurses choose the best way to make blood draws less painful for children.",[651],"Venipuncture Pain",[653],"Pediatric pain, venipuncture, distraction, cartoon projection , Ball squeezing","2026-02-13",{"date":656,"type":43},"2026-02-18",{"date":658,"type":23},"2026-03",{"date":660,"type":23},"2027-01",{"name":49,"class":50},""]