[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Beira Interior\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":73},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100612568","overweight-and-obesity-in-adolescents---sleep-behavioral-intervention-100612568",false,"NCT07255274","Overweight and Obesity in Adolescents - Sleep Behavioral Intervention","Treatment of Overweight and Obesity in Adolescents - Impact of a Sleep Behavioral Intervention - SLEEP-OB","SLEEP-OB","Inclusion Criteria:\n\n1. Informed consent from legal guardians and assent\u002Fconsent from the adolescent;\n2. Age between 13 and 17 years at the time of consent;\n3. Diagnosis of overweight (BMI z-score \\> 1 and ≤ 2) or obesity (BMI z-score \\> 2), according to WHO criteria;\n4. Sleep deprivation or poor sleep quality, based on the initial screening questionnaire.\n\nExclusion Criteria:\n\n1. Secondary obesity (e.g., hypothalamic, genetic, or endocrine causes);\n2. Comorbid psychiatric or neurological disorders (e.g., epilepsy, autism spectrum disorder) that affect sleep;\n3. Current treatment with selective serotonin reuptake inhibitors (SSRIs) or other medications affecting sleep.","ALL","13 Years","17 Years",{"count":21,"type":22},126,"ESTIMATED","INTERVENTIONAL",[25],"NA","Sleep plays a crucial role in energy balance, alongside diet and physical activity. Research has linked poor sleep quality and short sleep duration to obesity and cardiometabolic risk, such as insulin resistance and hypertension. The nature of this association is complex, and several mechanims have been suggested.\n\nScientific evidence suggests that sleep interventions may provide additional benefits in optimizing the effectiveness of overweight\u002Fobesity treatment in pediatric populations. Although some studies have explored this hypothesis, methodological heterogeneity hampers clear interpretation of the results.\n\nThe main goal of this clinical trial is is to evaluate the efficacy of a sleep behavioral intervention, combined with standard obesity treatment, in reducing adiposity (measured by BMI z-score, fat mass percentage, or fat-free mass index) in adolescents with overweight or obesity.\n\nThis randomized controlled trial will compare a control group receiving treatment as usual (or standard obesity treatment) with an intervention group receiving treatment as usual plus a sleep behavioral intervention.\n\nParticipants will be randomized into two groups: intervention and control. Throughout the study period, all medical consultations will include standard interventions focused on nutrition, physical activity\u002Fsedentary behavior, and other lifestyle factors. The sleep-focused intervention will be delivered by psychologists.\n\nParticipants will attend clinic visits every two months during the 6-month intervention period, and every three months during the subsequent 6-month follow-up period.",[28,29],"Obesity and Overweight","Sleep Disorder",[31,32,33,34],"Obesity","Sleep","Behavioral intervention","Adolescents","RECRUITING","2025-11-19",{"date":38,"type":39},"2025-12-01","ACTUAL",{"date":41,"type":39},"2025-06-03",{"date":43,"type":22},"2026-12",{"name":45,"class":46},"University of Beira Interior","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},"100530302","resistance-training-to-individuals-for-cognitive-impairment-with-dementia-100530302","NCT06185010","Resistance Training to Individuals for Cognitive Impairment With Dementia","Effects of Different Resistance Training Volumes on Cognitive Function, Oxidative Stress, Immunological Response, Lipid Profile, Glycemic Status, Liver Function, Muscle Function, Hemodynamic Response, and Physical Performance in Individuals With Mild Cognitive Impairment","TRAIN4BRAIN","Inclusion criteria:\n\n* Clinical diagnosis of mild cognitive impairment\n* SPPB score ≥ 3 points\n* Willingness to participate in the interventions and collaborate with the research team\n* Must be able to provide informed consent (oral or written)\n\nExclusion criteria:\n\n* Severe dementia\n* Severe comorbidity that negatively influences participation in the intervention\n* Color blindness\n* Fractures in the last three months",true,"50 Years",{"count":58,"type":22},80,[25],"This research project aims to analyze the effects of different resistance training volumes on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment. First the investigators will analyze the effects of a single resistance training session (acute effects) with one and three sets on hemodynamic and physical performance in individuals with mild cognitive impairment. After, the investigators will analyze the effects of an 8-week resistance training program with one or three sets on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment. The investigators hypothesize that a single resistance training session of one or three sets will increase the acute hemodynamic and physical performance stress in individuals with mild cognitive impairment, although with a higher magnitude in the session with three sets. Furthermore, we hypothesize that eight weeks of resistance training with one or three sets will induce similar improvements in cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment.",[62,63],"Mild Cognitive Impairment","Mild Dementia","2024-08-01",{"date":66,"type":39},"2024-08-06",{"date":68,"type":39},"2023-12-01",{"date":70,"type":22},"2024-12-31",{"name":45,"class":46},1,""]