[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Brasilia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":274},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,45,81,111,141,170,196,219,244],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100636874","the-effect-of-ozone-on-salivary-flow-in-patients-with-xerostomia-and-hyposalivation-after-radiotherapy-ozonexerostomi-100636874",false,"NCT07571356","The Effect of Ozone on Salivary Flow in Patients With Xerostomia and Hyposalivation After Radiotherapy (OZONEXEROSTOMI)","The Effect of Ozone Therapy on Salivary Flow and Quality of Life in Patients With Xerostomia and Hyposalivation After Head and Neck Radiotherapy","ozonexerostomi","Inclusion Criteria:\n\n* Patients who have undergone head and neck radiotherapy\n* Patient who have developed xerostomia\n* Patient who have developed hyposalivation\n\nExclusion Criteria:\n\n* Patients with active malignant disease\n* Patients who do not agree to sign the informed consent form","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","Patients who underwent head and neck radiotherapy and developed xerostomia and\u002For hyposalivation will be selected. The patients will be randomly assigned into two groups, defined as control and treatment.\n\nAll patients will complete the xerostomia-related quality of life questionnaires, XeQoLS (Xerostomia Quality of Life Scale) and OHIP (Oral Health Impact Profile). This qualitative assessment will be repeated 1 week after the 6th application and 1 week after the 12th application (T0, T6, and T12).\n\nThe quantitative assessment will be carried out through the collection of unstimulated and stimulated saliva at the same time points (T0, T6, and T12).\n\nPatients will undergo 12 sessions of ozone therapy, once a week, in gaseous form, at a concentration of 10 µg\u002FmL (micrograms per milliliter), applied directly into the major salivary glands.\n\nThe gas will be administered as follows:\n\n* Parotid glands: two distinct points per gland, 1 mL at each point.\n* Submandibular glands: one point per gland, 1 mL per point at 10 µg\u002FmL.\n* Sublingual glands: one point per gland, 1 mL per point at 10 µg\u002FmL. The ozone generator equipment will be supplied with medical oxygen (99.5% purity), Dental model, Philozon company.\n\nDisposable syringes will be Terumo, 10 mL, and the needle will be BD, 30\u002F13 mm.",[27],"Xerostomia Following Radiotherapy",[29,30,31,32],"xerostomia","ozone","hiposalivation","radio therapy","NOT_YET_RECRUITING","2026-05-04",{"date":36,"type":37},"2026-05-06","ACTUAL",{"date":39,"type":21},"2026-07-15",{"date":41,"type":21},"2028-01-15",{"name":43,"class":44},"University of Brasilia","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":64,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},"100632615","accuracy-of-the-polymerase-chain-reaction-of-ulnar-perineural-subcutaneous-aspirate-guided-by-ultrasound-for-the-diagnosis-and-monitoring-of-leprosy-cure-100632615","NCT07515989","Accuracy of the Polymerase Chain Reaction of Ulnar Perineural Subcutaneous Aspirate Guided by Ultrasound for the Diagnosis and Monitoring of Leprosy Cure","Does not exist","Inclusion Criteria:\n\nIndividuals aged 14 years or older;\n\nClinical suspicion of leprosy based on dermatologic or neurologic examination OR;\n\nPresence of peripheral nerve enlargement or skin lesions compatible with leprosy;\n\nAbility to provide written informed consent.\n\n\\-\n\nExclusion Criteria:\n\nPrevious treatment for leprosy;\n\nContraindication to the aspiration procedure (e.g., coagulopathy or anticoagulant therapy);\n\nLocal infection at the puncture site;\n\nInability or unwillingness to provide informed consent.","14 Years",{"count":54,"type":21},108,[24],"\\*\\*Brief Summary\\*\\*\n\nLeprosy is a chronic granulomatous infectious disease caused by \\*Mycobacterium leprae\\* or \\*Mycobacterium lepromatosis\\*, characterized by peripheral nerve involvement that may lead to progressive neurological damage, disability, and deformities if not diagnosed and treated early. The diagnosis of leprosy is primarily clinical and epidemiological, supported by laboratory methods such as bacilloscopy and biopsy; however, these tests have limited sensitivity, particularly due to the bacillus' tropism for peripheral nerve structures.\n\nUltrasonography has emerged as a non-invasive imaging method capable of detecting morphological changes in peripheral nerves, including nerve enlargement, fascicular abnormalities, and inflammatory hypervascularization. Despite its diagnostic value, ultrasonography alone cannot detect the presence of the bacillus.\n\nThis prospective cohort study aims to evaluate the diagnostic and prognostic accuracy of combining clinical evaluation, peripheral nerve ultrasonography, and molecular detection techniques using subcutaneous perineural aspirate. Patients with suspected leprosy attending the Leprosy Outpatient Clinic at the University Hospital of Brasília will undergo clinical evaluation, ultrasound examination of the ulnar nerves, and ultrasound-guided subcutaneous perineural aspirate for molecular detection of \\*Mycobacterium leprae\\* DNA and RNA using real-time PCR and RT-PCR.\n\nParticipants will be followed for one year, with assessments performed at diagnosis and after one year of treatment. The study will compare clinical, imaging, and molecular findings to determine whether perineural subcutaneous aspirate combined with ultrasonography improves early detection and diagnostic accuracy compared with conventional methods such as bacilloscopy and biopsy.\n\nThe study aims to contribute to improved diagnostic strategies for leprosy, enabling earlier detection of neural involvement and potentially reducing disease transmission and long-term disability.",[58,59,60,61,62,63],"Leprosy","Leprosy Neuropathy","Leprosy, Multibacillary","Leprosy--Patients","Mononeuropathies","Polyneuropathies",[58,65,66,67,68,69,70],"Slit Skin smear","Polimerase chain reaction","RLEP","16S","Sod","Periferal Nerve Ultrassound","RECRUITING","2026-04-02",{"date":74,"type":37},"2026-04-07",{"date":76,"type":37},"2026-01-01",{"date":78,"type":21},"2027-08-31",{"name":43,"class":44},1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},"100566124","trial-based-economic-evaluation-of-a-mobile-health-intervention-for-individuals-with-chronic-non-specific-low-back-pain-100566124","NCT06651099","Trial-based Economic Evaluation of a Mobile Health Intervention for Individuals With Chronic Non-specific Low Back Pain","A Multicenter Trial-based Economic Evaluation of a Mobile Health Intervention for Individuals With Chronic Non-specific Low Back Pain: Randomized Controlled Trial (eBack Trial)","eBack","Inclusion Criteria:\n\n* Adults aged between 18 and 65 years;\n* Self-reported low back pain for more than 12 consecutive weeks prior to the study, with pain intensity ≥4 in the numerical rating scale (NRS);\n* Not having participated in physiotherapy sessions for treatment of low back pain for at least 6 months prior to the start of the study;\n* Having a smartphone with internet access;\n* Self-management activation classified as Level 2 or higher (i.e., classifications of low, medium and high knowledge about self-management), according to the Patient Activation Measure (PAM) questionnaire.\n\nExclusion Criteria:\n\n* History of spinal trauma or fracture;\n* Diagnosis of spinal osteoarthritis, fibromyalgia, or rheumatic diseases; 3) Referred pain (from viscera, appendicitis, abdominal and pelvic pain);\n* Previous spinal surgery;\n* Presence of red flags, signs and\u002For symptoms of neurological impairment;\n* Pregnancy.","65 Years",{"count":91,"type":21},146,[24],"The aim of this trial is to assess the effectiveness and cost-effectiveness of a supervised and more personalised mhealth intervention compared with conventional exercise therapy in people with chronic non-specific low back pain.",[95],"Low Back Pain",[97,98,99,100,101],"Back pain","Mobile health","Economic evaluation","Exercise therapy","Self-management","2026-03-19",{"date":104,"type":37},"2026-03-24",{"date":106,"type":37},"2025-11-15",{"date":108,"type":21},"2027-01-20",{"name":43,"class":44},2,{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":80},"100627811","immediate-effects-of-neuromuscular-electrical-stimulation-on-pain-and-function-in-achilles-tendon-disorders-100627811","NCT07453485","Immediate Effects of Neuromuscular Electrical Stimulation on Pain and Function in Achilles Tendon Disorders","Immediate Effects of Neuromuscular Electrical Stimulation on Pain and Functional Performance in Individuals With Achilles Tendinopathy and Tendon Rupture: A Randomized Crossover Clinical Trial","Inclusion Criteria:\n\n* Primary complaint of pain localized in the midportion (2-6 cm proximal to the calcaneus) or insertion of the Achilles tendon, and\u002For a history of Achilles tendon rupture occurring at least 3 months prior to assessment.\n* Pain on palpation of the Achilles tendon.\n* Pain during load-bearing activities\n\nExclusion Criteria:\n\n* Exclusive diagnosis of bursitis confirmed by ultrasonographic assessment\n* Any other lower limb injury\n* History of lower limb surgery within the past year\n* Previous Achilles tendon tenoplasty performed less than 3 months prior to assessment","60 Years",{"count":120,"type":21},30,[24],"The Achilles tendon exhibits high tensile strength and can withstand extremely high loads. However, it is susceptible to injuries such as tendinopathies and ruptures, which are associated with structural alterations and loss of function. Strategies have been investigated to enhance clinical rehabilitation. Nevertheless, the effects of neuromuscular electrical stimulation on pain and functional improvement, as well as the optimal dosing parameters for the rehabilitation of Achilles tendon injuries, remain inconclusive. The aim of this study is to compare the immediate effects of two electrical stimulation protocols on pain, functional performance, peripheral oxygen extraction, and maximal tendon displacement during a single leg heel rise functional task in patients with Achilles tendinopathy and\u002For a history of Achilles tendon rupture. In addition, this study aims to characterize Achilles tendon structural properties and ankle plantarflexor muscle strength in this population.",[124,125],"Achilles Tendinopathy (AT)","Achilles Tendon Rupture",[127,128,129,130,131,132],"Achilles tendon","Achilles tendinopathy","Achilles tendon rupture","Neuromuscular electrical stimulation","Pain","Functional performance","2026-03-02",{"date":135,"type":37},"2026-03-06",{"date":137,"type":37},"2026-01-06",{"date":139,"type":21},"2029-12-30",{"name":43,"class":44},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":148,"maxAge":18,"enrollmentInfo":149,"targetDuration":150,"studyType":151,"phases":4,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":4},"100625581","chewable-tablets-produced-by-three-dimensional-printing-a-sensory-acceptability-study-in-children-and-adolescents-100625581","NCT07424495","Chewable Tablets Produced by Three-Dimensional Printing: A Sensory Acceptability Study in Children and Adolescents","ACEITA3D","Inclusion Criteria:\n\n* Children and adolescents aged 3 to 18 years receiving care at the Nutrition Outpatient Clinic of the Hospital da Criança de Brasília José Alencar (HCB).\n* Written informed consent provided by the legal guardian through the signing of the Informed Consent Form (ICF).\n* Assent from the child or adolescent, when applicable, expressed through the signing of the Informed Assent Form (IAF).\n\nExclusion Criteria:\n\n* Children or adolescents with dietary restrictions or known allergies to any component present in the formulations used in the study.\n* Children or adolescents with glucose-6-phosphate dehydrogenase (G6PD) deficiency.\n* Children or adolescents diagnosed with severe neurological, cognitive, or behavioral disorders that impair communication, comprehension, or response to the sensory scale.\n* Oral conditions, mucosal lesions, or dysphagia that prevent or significantly impair proper chewing or swallowing of the tablet (e.g., mucositis).\n* Refusal of the child\u002Fadolescent or legal guardian to participate in the study at any time, even after prior consent has been provided.","3 Years",{"count":20,"type":21},"2 Days","OBSERVATIONAL","The lack of appropriate pediatric formulations compromises adherence and the effectiveness of oral treatment in children, mainly due to the splitting of adult tablets and low sensory acceptability. This observational, analytical, and cross-sectional study aims to evaluate the acceptability of a novel pediatric dosage form consisting of placebo chewable tablets produced by 3D printing, with a focus on palatability and feasibility for dose personalization. Children and adolescents aged 3 to 18 years receiving care at the Nutrition Outpatient Clinic of the Hospital da Criança de Brasília José Alencar will be invited to participate. The study will be conducted in two stages. In the first stage, acceptability of a bear-shaped chewable tablet will be assessed, as well as preference among different flavors. In the second stage, preference for chewable tablets with or without xylitol will be investigated, in addition to dysgeusia associated with diseases or chronic medication use. Acceptability will be measured using a 5-point facial hedonic scale, evaluator observation, and age-appropriate questionnaires. The study is expected to identify the most accepted flavors and sweetness intensities, as well as to evaluate the acceptability of the 3D-printed dosage form, contributing to the development of safer, more attractive, and personalized pediatric medicines.",[154],"Palatability Assessment of 3D-printed Chewable Tablets in Children and Adolescents",[156,157,158,159,160,161],"Palatability","3D Printing","Chewable Tablet","Pediatric Formulation","Sensory Acceptability","Pharmaceutical Technology","2026-02-20",{"date":164,"type":37},"2026-02-24",{"date":166,"type":21},"2027-03",{"date":168,"type":21},"2028-12",{"name":43,"class":44},{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":177,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":80},"100552385","integrated-learning-support-system-based-on-immersive-simulated-training-for-nursing-students-100552385","NCT06472401","Integrated Learning Support System Based on Immersive Simulated Training for Nursing Students","Integrated Learning Support System Based on Immersive Simulated Training for Nursing Students: Randomized Controlled Trial","Inclusion Criteria:\n\n* Be aged ≥ 18 years old;\n* Students enrolled in the last two years of the undergraduate nursing course;\n* Students who have self-declared internet access in their homes to complete the course's online modules.\n\nExclusion Criteria:\n\n* Students who have previous training and\u002For professional experience in the health area;\n* Students who do not complete at least 75% of the workload of the proposed course.",true,{"count":179,"type":21},95,[24],"This study aims to evaluate the effectiveness of an Integrated Learning Support System (ILSS) in preparing undergraduate nursing students for immersive simulated training in managing drug-induced nephrotoxicity. The study hypothesizes that the ILSS, which accommodates different learning styles, will be more effective in reducing stress and anxiety compared to the standard learning model (SLM). The research will involve a parallel randomized controlled trial with 96 students from two Brazilian institutions. The students will be divided into control and experimental groups, with the latter using the ILSS in addition to SLM during preparation. The study will assess outcomes such as knowledge acquisition, skill development, and stress reduction using various instruments, including the Lasater Clinical Judgment Rubric and DASS-21. The study's findings aim to validate the ILSS as a tool to enhance learning outcomes and reduce stress and anxiety, thereby promoting better professional development and patient safety in nursing practice.",[183,184,185,186,187],"Simulation Training","Learning","Educational Technology","Nephrotoxicity","Physiological Stress","2024-07-29",{"date":190,"type":37},"2024-07-31",{"date":192,"type":21},"2024-08-01",{"date":194,"type":21},"2025-12",{"name":43,"class":44},{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":177,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":22,"phases":205,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":80},"100536593","efficacy-of-gamification-with-escape-room-for-arrhythmia-identification-in-critical-patients-100536593","NCT06266845","Efficacy of Gamification With Escape-Room for Arrhythmia Identification in Critical Patients","Efficacy of Gamification With Escape-Room for Arrhythmia Identification in Critical Patients: an Experiment With Nursing Undergraduates","Inclusion Criteria:\n\n* Students enrolled in the undergraduate nursing program who have successfully completed the course related to adult and elderly health.\n\nExclusion Criteria:\n\n* Healthcare professionals, including those participants who, at any point during the research stages, choose to withdraw or who have not completed\u002Fparticipated in one of the study phases.",{"count":204,"type":21},53,[24],"Introduction: Health education provided through the escape-room is still a recent approach in educational methodology and tends to be a strategy that benefits nursing students, particularly in gaining knowledge and skills. However, few studies have explored the use of both in-person and virtual escape-room as an educational methodology in nursing. Objective: To assess the effectiveness of the gamification strategy through the in-person escape-room model compared to the virtual model in enhancing cognitive and affective competencies for recognizing cardiac arrhythmias in critical care patients within the nursing field. Method: A randomized clinical trial to be conducted with nursing students from higher education institutions in the Federal District, Brazil. Students will undergo a theoretical class on cardiac arrhythmias in critical patients and will then be randomized to experience either the in-person or virtual escape-room scenario. Knowledge tests, the Depression, Anxiety, and Stress Scale, Satisfaction and Self-confidence Scale in nursing management learning, and perceived gains will be administered pre and post-intervention. Results with p≤0.05 will be considered significant. Expected Results: It is anticipated that this study will contribute to the enhancement and broadening of cognitive and affective competencies in nursing students, improving the quality of care through an active educational strategy like the escape-room, and consequently reducing costs for the Unified Health System by minimizing errors in recognizing clinical changes in critical patients. Additionally, the study aims to address gaps in understanding the use of educational escape-rooms in the field of nursing.",[208,209,210],"Arrythmia","Health Education","Escape-Room","2024-07-08",{"date":213,"type":37},"2024-07-10",{"date":215,"type":37},"2024-03-04",{"date":217,"type":21},"2024-12-31",{"name":43,"class":44},{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":226,"targetDuration":4,"studyType":22,"phases":228,"briefSummary":229,"conditions":230,"keywords":233,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":80},"100533122","continuous-radiofrequency-in-hip-osteoarthritis-pain-a-randomized-clinical-trial-100533122","NCT06221709","Continuous Radiofrequency in Hip Osteoarthritis Pain: A Randomized Clinical Trial.","Continuous Radiofrequency in Hip Osteoarthritis Pain: A Protocol of a Randomized Clinical Trial","Inclusion Criteria:\n\n* Individuals ≥ 18 years of age, with symptomatic unilateral hip osteoarthritis, grades II and III according to the Kellgreen and Lawrance classification, hip pain for more than six months (medial, anterior, anterolateral, and\u002For lateral region) will be included.\n\nExclusion Criteria:\n\n* Individuals with radiculopathy and ipsilateral irradiation, osteonecrosis of the femoral head, previous arthroplasty on the hip to be studied or surgical scar that could lead to changes in the anatomy of the hip, cases of high dislocation of the hip, pain exclusively in the posterior region, symptomatic ipsilateral knee osteoarthritis, intra-articular infiltration of corticosteroids or hyaluronic acid in the hip for less than six months, patients with neurological diseases, peripheral neuropathy or psychiatric diseases, use of a pacemaker or Prothrombin Activity Time (INR) \\> 3.",{"count":227,"type":21},70,[24],"This will be a prospective, single-center, double-blinded, randomized study designed to compare the efficacy of the intraarticular injection of a corticosteroid and the Conventional Radiofrequency (CRF) of the anterior sensory branches to the hip in controlling pain and improving function related to hip osteoarthritis.",[231,232],"Hip Osteoarthritis","Hip Pain Chronic",[234,235],"denervation","Radiofrequency ablation","2024-01-14",{"date":238,"type":37},"2024-01-24",{"date":240,"type":21},"2024-02-01",{"date":242,"type":21},"2027-04-30",{"name":43,"class":44},{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":17,"minAge":250,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":22,"phases":252,"briefSummary":255,"conditions":256,"keywords":259,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":80},"100519203","phase-2-pilot-study-oral-treatment-of-american-tegumentary-leishmaniasis-cutaneous-and-mucosal-forms-in-the-elderly-100519203","NCT06040489","Pilot Study: Oral Treatment of American Tegumentary Leishmaniasis (Cutaneous and Mucosal Forms) in the Elderly","Inclusion Criteria:\n\n* Active confirmed cutaneous leishmaniasis ou mucosal leishmaniasis\n* Use of highly effective contraceptive method and a negative serologic pregnancy test (beta - HCG), if female in fertile phase\n* Agree and sing informed consent form\n\nExclusion Criteria:\n\n* Previous treatment with leishmanicidal drugs in the last 6 months\n* Pre-treatment electrocardiographic changes that contraindicate the use of liposomal amphotericin B (QTc greater than 450ms)\n* Serum creatinine or urea 1.5 times the upper limit of normal\n* Patients with severe or decompensated liver, kidney, heart disease, Diabetes Mellitus\n* history of any hypersensitivity reaction to liposomal amphotericin B, miltefosine and\u002For pentoxifylline\n* Pregnant and breastfeeding women\n* Patients with Acquired Immunodeficiency Syndrome (AIDS) or other immunodeficiency","50 Years",{"count":20,"type":21},[253,254],"PHASE2","PHASE3","Randomised clinical trial comparing oral miltefosine associated with pentoxifylline to intravenous liposomal amphotericin b for the treatment of cutaneous and mucosal leishmaniasis",[257,258],"Leishmaniasis; Brazilian","Leishmaniasis, Mucocutaneous",[260,261,262,263,264,265],"Elderly","Miltefosine","Leishmaniasis","Pentoxifylline","Liposomal amphotericin b","Treatment","2023-09-13",{"date":268,"type":37},"2023-09-15",{"date":270,"type":37},"2022-06-22",{"date":272,"type":21},"2026-06",{"name":43,"class":44},""]