[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Castilla-La Mancha\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":571},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,49,75,107,139,161,183,210,241,270,314,341,368,389,417,459,492,519,543],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100642371","metformin-withdrawal-in-metabolic-syndrome-100642371",false,"NCT07659444","Metformin Withdrawal In Metabolic Syndrome","Effects of 14-Day Metformin Withdrawal on OGTT-Derived Insulin Sensitivity in Adults With Metabolic Syndrome: A Randomized Controlled Trial","METMS","Inclusion Criteria:\n\n* Currently treated with metformin as part of their usual medical care for at least 12 months before enrolment.\n* Diagnosis of metabolic syndrome according to established clinical criteria, based on the presence of at least three of the following components: increased waist circumference, elevated triglycerides, reduced HDL cholesterol, elevated blood pressure or antihypertensive treatment, and elevated fasting glucose or treatment for dysglycemia.\n* Stable metformin dose for at least 3 months before enrolment.\n* Willing and medically able to temporarily discontinue metformin for 14 days if assigned to the metformin discontinuation group.\n* Able and willing to undergo repeated oral glucose tolerance tests, venous catheter placement, repeated blood sampling, indirect calorimetry measurements, blood pressure measurements, and heart rate measurements.\n* willing to wear a continuous glucose monitoring device during the study period.\n* Preserved kidney function at baseline, defined as estimated glomerular filtration rate ≥60 mL\u002Fmin\u002F1.75 m² and urine albumin-to-creatinine ratio \\\u003C30 mg\u002Fg, or values considered clinically acceptable by the study physician.\n* No previous history of clinically significant diabetes-related complications, including diabetic retinopathy, diabetic foot disease, severe peripheral neuropathy, or diabetic kidney disease.\n\nExclusion Criteria:\n\n* Diagnosis of type 1 diabetes.\n* Current treatment with insulin or other glucose-lowering medications.\n* Previous history of severe hypoglycemia, diabetic ketoacidosis, hyperosmolar hyperglycemic state, or other acute diabetes-related metabolic complications.\n* Uncontrolled diabetes or clinically unsafe glycemic status at screening, defined as HbA1c above 8.0 %, fasting plasma glucose above 160 mg\u002Fdl, or any other glycemic value considered unsafe by the study physician.\n* Known allergy or intolerance to materials used in the continuous glucose monitoring device, adhesive patches, venous catheter, or study procedures.","ALL","18 Years",{"count":20,"type":21},28,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to investigate how a short-term interruption of metformin treatment affects insulin sensitivity, glucose control, and metabolic flexibility in adults with metabolic syndrome who are taking metformin as part of their usual medical treatment. Temporary interruptions in metformin treatment may occur in real-life situations, such as missed doses, medication access problems, travel, or planned short-term discontinuation for clinical reasons. This study aims to understand whether stopping metformin for 14 days leads to rapid changes in glucose metabolism or whether the effects of previous metformin treatment may persist during a short period without the medication.\n\nThe main questions it aims to answer are:\n\nDoes stopping metformin for 14 days worsen glucose control or insulin sensitivity measured by oral glucose tolerance tests, HbA1c, and continuous glucose monitoring?\n\nDoes stopping metformin for 14 days affect metabolic flexibility, measured by indirect calorimetry during the oral glucose tolerance test?\n\nDoes stopping metformin for 14 days affect blood lipids, liver and inflammatory markers, red blood cell parameters, kidney function markers, fasting lactate levels, blood pressure, or heart rate?\n\nResearchers will compare participants who stop metformin for 14 days with participants who continue their usual metformin treatment to see whether temporary metformin discontinuation affects insulin sensitivity, glucose control, metabolic flexibility, and other cardiometabolic markers.\n\nParticipants in the metformin discontinuation group will stop taking metformin for 14 days. They will attend study visits on day 0, day 4, day 7, and day 14. At each visit, they will complete an oral glucose tolerance test, have blood samples taken, and undergo indirect calorimetry measurements before and after the glucose drink. Blood pressure and heart rate will also be measured during the test. Participants will wear a continuous glucose monitor throughout the 14-day period to track glucose levels and help detect any potentially unsafe increase in blood glucose.\n\nParticipants in the usual-treatment group will continue taking metformin as prescribed. They will attend study visits on day 0 and day 14. At each visit, they will complete an oral glucose tolerance test, have blood samples taken, and undergo indirect calorimetry, blood pressure, and heart rate measurements during the test.\n\nAt the study visits, researchers will assess glucose and insulin responses, HbA1c, continuous glucose monitoring data, metabolic flexibility, blood lipid profile, liver and inflammatory markers, red blood cell parameters, kidney function markers, fasting lactate levels, blood pressure, and heart rate.",[27,28],"Metabolic Syndrome (MetS)","Glucose Intolerance",[30,31,32,33,34,35],"MetS","Metabolic Syndrome","Metformin","Insulin Sensitivity","Metabolic Flexibility","OGTT","RECRUITING","2026-06-16",{"date":39,"type":40},"2026-06-22","ACTUAL",{"date":42,"type":40},"2026-04-05",{"date":44,"type":21},"2026-08-30",{"name":46,"class":47},"University of Castilla-La Mancha","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100624111","restoring-metabolic-flexibility-through-combined-exercise-in-breast-cancer-survivors-a-randomized-controlled-trial-100624111","NCT07405385","REstoring Metabolic FLEXibility Through Combined Exercise in Breast Cancer Survivors: A Randomized Controlled Trial.","REFLEX","Inclusion Criteria:\n\n* Women aged between 18 and 70 years.\n* Confirmed diagnosis of breast cancer in stages I to III.\n* Received neo-adjuvant or adjuvant chemotherapy and completed the chemotherapy treatment within the 6 months prior to study enrolment.\n* Residency within a distance of less than 40 km from the Hospital Universitario de Toledo.\n\nExclusion Criteria:\n\n* Diagnosis of stage IV breast cancer.\n* Undergone major surgery within the 4 months prior to enrolment or scheduled for breast reconstruction surgery during the study period.\n* Diagnosis of diabetes mellitus with poor glycaemic control, defined as an HbA1c value greater than or equal to 8.5%.\n* Presence of an acute infectious disease.\n* Absolute or relative medical contraindications for physical exercise or maximal exercise stress testing, according to the American College of Sports Medicine (ACSM) guidelines.\n* Serious cardiac or cardiovascular disease, including a history of myocardial infarction, heart failure, or known cardiomyopathy.\n* Regular consumption of beta-blockers or any medication that alters the functioning of the nervous system.\n* Currently active, defined as engaging in more than 150 minutes per week of structured physical exercise during the 6 months prior to enrolment.","FEMALE","70 Years",{"count":59,"type":21},44,[24],"The REFLEX study is a randomized, controlled clinical trial designed to evaluate the impact of a 16-week supervised, combined exercise program on metabolic flexibility and cardiorespiratory fitness in breast cancer survivors. While cancer treatments have significantly improved survival rates, the disease and its therapies often cause systemic mitochondrial dysfunction and muscle loss. This leads to persistent \"metabolic inflexibility\"-a reduced ability to efficiently switch between burning carbohydrates and fats for energy. This inflexibility, exacerbated by sedentary behavior and cancer-related fatigue, can severely diminish a patient's functional autonomy and overall quality of life. The trial focuses on assessing whether exercise can restore this metabolic adaptability in women aged 18 to 70 with stage I-III breast cancer who are currently on hormonal treatment and completed neo\u002Fadjuvant chemotherapy within the past 6 months.\n\nThe study operates on the primary hypothesis that an individualized exercise intervention will significantly improve the participants' metabolic flexibility-measured via the metabolic crossover point-and overall aerobic capacity (VO2max) when compared to a control group. Additionally, the trial will analyze secondary outcomes, including changes in cardiovascular and metabolic risk factors, muscle strength, body composition (such as bone mineral density), and patient-reported outcomes assessing quality of life, fatigue, joint pain, anxiety, and depression.\n\nA total of 44 participants will be randomly assigned to either the intervention or control group. Participants in the intervention group will complete a 16-week program consisting of two weekly supervised sessions. Each session lasts between 55 and 85 minutes and includes a tailored combination of aerobic and strength training based on the individual's baseline fitness and metabolic thresholds. Participants in the control group. will receive standard educational materials via email, featuring healthy lifestyle and exercise guidelines from the World Health Organization (WHO) and the American College of Sports Medicine (ACSM).\n\nTo evaluate the program's effectiveness, comprehensive medical and functional assessments will be conducted at baseline, immediately after the 16-week intervention, and at a 3-month follow-up. These evaluations include submaximal and maximal exercise tests on a cycle ergometer to analyze respiratory gases, detailed blood tests, body composition imaging (DXA scans), and maximum dynamic strength testing. Ultimately, the research aims to generate high-quality evidence to optimize standard exercise recommendations for breast cancer survivors and improve their long-term health and resilience.",[63,64,65,34],"Cancer","Breast Cancer","Neoplasm","NOT_YET_RECRUITING","2026-05-25",{"date":69,"type":40},"2026-05-28",{"date":71,"type":21},"2026-09",{"date":73,"type":21},"2027-12",{"name":46,"class":47},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100640478","spanish-etips-for-early-therapy-in-perinatal-stroke-100640478","NCT07605988","Spanish eTIPS for Early Therapy in Perinatal Stroke","Spanish eTIPS: Translation, Cross-Cultural Adaptation, and Pilot Randomized Feasibility Study of Early Therapy in Perinatal Stroke for Spanish-Speaking Families","eTIPS-ES","Inclusion Criteria:\n\n* Infants with confirmed unilateral perinatal stroke diagnosis by neuroimaging, identified within first 3 months of life\n* Age at recruitment ≤3 months postnatal (intervention starts when clinically stable, maximum term-equivalent age)\n* Written informed consent from parents\u002Flegal guardians\n\nExclusion Criteria:\n\n* Known progressive neurodegenerative disorder or severe medical comorbidity preventing participation (e.g., ventilation-dependent respiratory failure)\n* Extensive bilateral intracerebral lesion making lateralized intervention irrelevant\n* Concurrent participation in another clinical trial with interfering treatment","0 Months","6 Months",{"count":86,"type":21},20,[24],"This study adapts and evaluates the Spanish version of eTIPS, an early home-based therapy program for infants at risk of unilateral cerebral palsy after perinatal stroke. The project has three parts: translation and cultural adaptation of the original materials, a pilot randomized feasibility study comparing eTIPS with usual care, and a qualitative study exploring family experiences, barriers, and facilitators to using the program at home.\n\nIn the first part, the study team will translate and culturally adapt the eTIPS materials for Spanish-speaking families, review them with experts, and test whether the content is clear, relevant, and usable. In the second part, families with infants diagnosed with perinatal stroke or at high risk of unilateral cerebral palsy will be assigned to either the eTIPS program or usual clinical care to assess recruitment, retention, adherence, safety, acceptability, and preliminary effects on infant motor development and family outcomes. In the third part, caregivers in the intervention group will take part in interviews to better understand how the program fits into daily life and what could improve future implementation.",[90,91,92],"Perinatal Stroke and Risk of Unilateral Cerebral Palsy","Early Parent-delivered Home-based Intervention","Spanish Cross-cultural Adaptation of eTIPS",[94,95,96,97,98],"eTIPS","perinatal stroke","unilateral cerebral palsy","early intervention","infant rehabilitation","2026-05-18",{"date":101,"type":40},"2026-05-26",{"date":103,"type":21},"2026-09-01",{"date":105,"type":21},"2028-12-31",{"name":46,"class":47},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":4},"100630452","intensive-somatosensory-camp-for-manual-function-and-participation-in-children-with-unilateral-cerebral-palsy-100630452","NCT07487857","Intensive Somatosensory Camp for Manual Function and Participation in Children With Unilateral Cerebral Palsy","Intensive Somatosensory Camp for Manual Function and Participation in Children With Unilateral Cerebral Palsy: a Randomnized Controlled Trial","CAMPUSENS","Inclusion Criteria:\n\n* diagnosis of spastic CP\n* aged between 5 and 15 years of age\n* able to follow simple verbal instructions and complete all the necessary tests according to their ages\n* MACS level I-III\n\nExclusion Criteria:\n\n* uncontrolled epilepsy episodes in the 6 months prior to the start of the study\n* botulinum toxin in the last 6 months\n* orthopedic or neurological surgery in the 12 months prior to the start of the study or scheduled during the intervention development period\n* visual or cognitive disabilities that interfere with treatment\n* unable to actively participate in the activities","5 Years","15 Years",{"count":118,"type":21},26,[24],"This study will evaluate whether an intensive day camp that combines somatosensory and motor training for the affected upper limb improves hand function and participation in children with unilateral cerebral palsy more than an intensive motor-only camp of equal duration and intensity. Children aged 5 to 15 years with unilateral spastic cerebral palsy and Manual Ability Classification System (MACS) levels I-III will be randomly assigned to one of two intervention groups. The experimental group will receive an 8-day, 40-hour camp including structured tactile, proprioceptive and vestibular stimulation integrated into meaningful functional tasks for the upper limb. The control group will receive an 8-day, 40-hour camp focused exclusively on intensive motor training without specific somatosensory stimulation.\n\nThe primary outcome is the change in spontaneous bimanual performance of the affected hand, measured with the Assisting Hand Assessment (AHA). Secondary outcomes include measures of unilateral upper limb function, somatosensory function, hand grip strength, gross motor function, balance, trunk control, participation in daily activities and objective upper limb activity measured with wrist-worn accelerometers. Outcomes will be assessed at baseline, immediately after the intervention, and at follow-up visits approximately 2 and 3 months after the camp.",[122],"Cerebral Palsy",[96,124,125,126,127,128,129,130],"hemiparesis","upper limb function","somatosensory training","intensive rehabilitation","bimanual performance","pediatric","rehabilitation","2026-03-17",{"date":133,"type":40},"2026-03-23",{"date":135,"type":21},"2026-06-20",{"date":137,"type":21},"2026-12-31",{"name":46,"class":47},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":17,"minAge":147,"maxAge":18,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":4},"100596168","hemimprove-10-in-children-and-adolescents-with-unilateral-cerebral-palsy-100596168","NCT07041944","HEMImprove 1.0 in Children and Adolescents With Unilateral Cerebral Palsy","\"Efficacy and Usability of HEMImprove 1.0 Gamified Mobile Application for Upper Limb Rehabilitation in Adolescents With Unilateral Cerebral Palsy: A Randomized Controlled Trial\"","HEMImprove-APP","Inclusion Criteria:\n\n* Adolescents aged 12 to 18 years diagnosed with unilateral cerebral palsy.\n* Ability to use the mobile app independently or with minimal assistance.\n* Informed consent provided.\n\nExclusion Criteria:\n\n* Severe cognitive impairment.\n* Recent upper limb surgery (within 6 months).\n* Recent botulinum toxin treatment (within 3 months).\n* Other neurological or orthopedic disorders affecting upper limb function.","12 Years",{"count":149,"type":21},36,[24],"This study aims to evaluate the effectiveness and usability of HEMImprove 1.0, a gamified mobile application designed to improve upper limb motor function in adolescents with unilateral cerebral palsy. Participants will be randomly assigned to an intervention group using the app or a control group performing conventional home exercises. The intervention will last four weeks, with assessments before and after the intervention to measure motor function, motivation, and quality of life improvements.",[153],"Unilateral Cerebral Palsy",{"date":155,"type":40},"2026-03-18",{"date":157,"type":21},"2026-03-01",{"date":159,"type":21},"2027-12-01",{"name":46,"class":47},{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":48},"100625584","predictive-models-on-psychosocial-profile-fatigue-and-sleep-quality-100625584","NCT07424534","Predictive Models on Psychosocial Profile, Fatigue and Sleep Quality","Development of Artificial Intelligence-Based Predictive Models to Analyze the Impact of Psychosocial Profile, Fatigue, and Sleep Quality on Disease Severity in Patients With Fibromyalgia","Inclusion Criteria:\n\n* Age between 18 and 65 years.\n* Fullfilled the 2010 American Collegue of Rheumathology criteria for fibromyalgia.\n* Understanding of spoken and written Spanish.\n\nExclusion Criteria:\n\n* Diagnosed psychiatric pathology.\n* Rheumatic pathology not medically controlled.\n* Neurological pathologies that make evaluations difficult.","65 Years",{"count":170,"type":21},150,"OBSERVATIONAL","The primary goal of this research project is to develop different prediction models in fibromyalgia disease through the application of machine learning techniques and to assess the explainability of the results. As specific objective the research project intends to evaluate the influence of psychosocial variables, fatigue, and sleep quality on the prediction of disease severity in patients with fibromyalgia using an artificial intelligence-based model.",[174],"Fibromyalgia","2026-03-03",{"date":177,"type":40},"2026-03-05",{"date":179,"type":21},"2026-02-24",{"date":181,"type":21},"2026-11-30",{"name":46,"class":47},{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":168,"enrollmentInfo":190,"targetDuration":4,"studyType":22,"phases":192,"briefSummary":193,"conditions":194,"keywords":196,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":48},"100627710","lumbar-and-gluteal-motor-control-in-chronic-low-back-pain-100627710","NCT07452172","Lumbar and Gluteal Motor Control in Chronic Low Back Pain","Efficacy of a Combined Lumbar Motor Control and Gluteal Strengthening Program on Pain and Function in Chronic Non-specific Low Back Pain","Inclusion Criteria:\n\n* Age between 18 and 65 years.\n* Non-specific low back pain with an intensity greater than 3\u002F10 on a visual analogue scale.\n* Symptom duration longer than 3 months.\n* Sufficient understanding of spoken and written Spanish to adequately comprehend the intervention instructions and complete the assessments.\n\nExclusion Criteria:\n\n* Severe lumbar or hip trauma within the previous 6 weeks.\n* Prior vertebral fracture or lumbar disc herniation.\n* Fibromyalgia.\n* Active oncological disease.\n* Diagnosis of a severe psychiatric disorder.\n* Pregnancy.\n* Uncontrolled rheumatologic pathology.\n* Coexisting auto-immune pathology or chronic inflammatory disease.",{"count":191,"type":21},54,[24],"The present study aims to evaluate the effectiveness of an 8-week combined lumbar motor control and gluteal muscle strengthening program in individuals with chronic non-specific low back pain",[195],"Low Back Pain",[197,198,199,200,201,202],"Motor control","Strengthening","Gluteal muscles","Pain","Disability","Low back pain","2026-02-27",{"date":177,"type":40},{"date":206,"type":21},"2026-03-02",{"date":208,"type":21},"2026-05-29",{"name":46,"class":47},{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":56,"minAge":218,"maxAge":168,"enrollmentInfo":219,"targetDuration":4,"studyType":22,"phases":221,"briefSummary":222,"conditions":223,"keywords":225,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":48},"100625161","bipolar-radiofrequency-for-genitourinary-syndrome-of-menopause-100625161","NCT07419035","Bipolar Radiofrequency for Genitourinary Syndrome of Menopause","Efficacy of Bipolar Radiofrequency for Genitourinary Syndrome of Menopause in Postmenopausal Women: A Randomized, Sham-Controlled Clinical Trial","BRF-GSM","Inclusion Criteria:\n\n* Women aged 40 to 65 years\n* Postmenopausal status\n* Presence of at least one symptom of genitourinary syndrome of menopause (e.g., vaginal dryness, irritation, pruritus, urinary symptoms, or dyspareunia)\n* Sexual activity at least once per month\n* Ability to understand and complete study questionnaires\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Active vaginal infection\n* Neurological, neoplastic, or sexually transmitted diseases\n* Diagnosis of vulvodynia or vaginismus\n* Pelvic organ prolapse stage II or higher\n* Pelviperineal hypoesthesia\n* Presence of pacemaker or other electronic implantable devices\n* Use of estrogen hormonal therapy within the previous 3 months\n* History of pelvic radiotherapy\n* Pelvic surgery within the previous 6 months\n* Active anticoagulant therapy\n* Previous vaginal laser or ablative vaginal rejuvenation procedures within the previous 6 months\n* Cognitive impairment preventing completion of questionnaires","40 Years",{"count":220,"type":21},40,[24],"This randomized, sham-controlled clinical trial aims to evaluate the efficacy and safety of bipolar radiofrequency in the treatment of genitourinary syndrome of menopause (GSM) in postmenopausal women. Participants will be randomly assigned to receive either active bipolar radiofrequency treatment or a sham procedure.\n\nThe primary objective is to determine whether bipolar radiofrequency improves vaginal and sexual function. Secondary objectives include assessment of pain with vaginal penetration, vaginal lubrication and tissue distensibility, patient-reported vulvovaginal symptom severity, and treatment safety and tolerability.",[224],"Genitourinary Syndrome of Menopause (GSM)",[226,227,228,229,230,231,232],"bipolar radiofrequency","menopause","sexual function","dyspareunia","vaginal atrophy","postmenopausal women","radiofrequency therapy","2026-02-11",{"date":235,"type":40},"2026-02-18",{"date":237,"type":21},"2026-03-15",{"date":239,"type":21},"2026-09-30",{"name":46,"class":47},{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":17,"minAge":249,"maxAge":18,"enrollmentInfo":250,"targetDuration":4,"studyType":22,"phases":252,"briefSummary":253,"conditions":254,"keywords":256,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":267,"leadSponsor":269,"locationsCount":4},"100599974","home-improve-telerrehabilitation-system-100599974","NCT07091461","HOMe-IMprove Telerrehabilitation System","HOMe-IMprove Telerrehabilitation System for CHilDren With Cerebral Palsy","HOMIMTES-CHilD","Inclusion Criteria:\n\n* Confirmed diagnosis of infantile unilateral cerebral palsy\n* Age between 6 and 18 years\n* Stable home Wi-Fi access and space to perform exercises\n* Manual Ability Classification System (MACS) level ≤ 3\n* Informed consent from legal guardian and assent from the child (if \\\u003C12 years)\n\nExclusion Criteria:\n\n* Severe neurological or psychiatric comorbidities\n* Recent orthopedic surgery (\\\u003C12 months) or botulinum toxin treatment (\\\u003C6 months)\n* Concurrent participation in other intervention studies","6 Years",{"count":251,"type":21},24,[24],"This pilot study aims to assess the feasibility, adherence, and preliminary efficacy of a home-based telerehabilitation protocol using the HOME Kit Tablet system in children aged 6 to 18 years with cerebral palsy. The study follows a randomized controlled design with parallel groups and single-blind evaluation. The intervention group will use a digitally supervised rehabilitation system, while the control group will follow a traditional home therapy protocol without technological tools.",[255],"Cerebral Palsy Infantile",[257,258,259,260,261,262],"home","children","infantile cerebral palsy","family","upper extremity","balance","2026-02-04",{"date":265,"type":40},"2026-02-05",{"date":157,"type":21},{"date":268,"type":21},"2027-04-01",{"name":46,"class":47},{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":278,"sex":17,"minAge":18,"maxAge":279,"enrollmentInfo":280,"targetDuration":4,"studyType":22,"phases":282,"briefSummary":283,"conditions":284,"keywords":292,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":48},"100615438","impact-of-nut-consumption-on-mental-health-in-young-adults-100615438","NCT07292610","Impact of Nut Consumption on Mental Health in Young Adults","Impact of Nut Consumption on Mental Health in Young Adults: a Randomized Controlled Trial","NUTS4BRAIN-RCT","Participants must meet all the following criteria to be considered eligible for selection and randomization:\n\nInclusion Criteria:\n\n* Age: Participants must be between 18 and 25 years old.\n* Academic Status: Participants must be enrolled as university students.\n* Field of Study: Participants may come from any academic program offered at the Cuenca Campus, including Nursing, Social Work, Education, Fine Arts, Engineering, Journalism, and Teaching.\n\nParticipants will be excluded from the study if they have any of the following conditions, based on self-reported information:\n\nExclusion Criteria:\n\n* Allergies: Known nut allergy.\n* Self-reported cardiovascular, metabolic, gastrointestinal or mental health disorder.",true,"24 Years",{"count":281,"type":21},135,[24],"Nuts have a high nutrient density, and numerous studies have reported their cardiometabolic benefits. Although observational studies in adults have indicated a potential link between nut consumption and improved mental health, there is still insufficient evidence from experimental studies to draw firm conclusions about this association.",[285,286,287,288,289,290,291],"Depression Disorder","Anxiety","Mental Health","Stress","Cognition","BDNF","General Wellbeing",[293,294,295,296,297,287,298,286,289,299,300,301,302,303,304,305,290],"RCT","Dietary Intervention","Nut consumption","young adults","Randomized controlled trial","Depression","University students","Sleep quality","Academic performance","Walnuts","Almonds","Pistachios","Hazelnut","2025-12-15",{"date":308,"type":40},"2025-12-18",{"date":310,"type":40},"2025-11-24",{"date":312,"type":21},"2027-04",{"name":46,"class":47},{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":320,"eligibilityCriteria":321,"healthyVolunteers":278,"sex":17,"minAge":115,"maxAge":322,"enrollmentInfo":323,"targetDuration":4,"studyType":22,"phases":325,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":340},"100615432","learning-cardiopulmonary-resuscitation-in-the-school-setting-rcp-know-project-100615432","NCT07292532","Learning Cardiopulmonary Resuscitation in the School Setting: RCP-KNOW Project.","Out-of-hospital Cardiorespiratory Arrest and Learning Cardiopulmonary Resuscitation in the School Setting: Evidence Synthesis","RCP-KNOW","Inclusion Criteria:\n\n* Schools that have at least one complete year of 1st, 2nd, 3rd, 4th, 5th and 6th year of Primary Education, in which the School Council has given its approval for their participation.\n* Schoolchildren who wish to participate must:\n* Belong to the courses from 1st to 6th grade of Primary Education\n* Understand the written and spoken Spanish language\n* Not have any physical, mental or cognitive pathology that prevents them from participating in the project.\n* Their father\u002Fmother or guardian must have signed the informed consent to be able to participate in the project.","13 Years",{"count":324,"type":21},550,[24],"Title: Out-of-hospital cardiorespiratory arrest and learning cardiopulmonary resuscitation in the school setting: evidence synthesis. CPR-KNOW PROYECT.\n\nBackground: The high incidence, associated morbidity and mortality, and the great individual, social and economic impact of out-of-hospital cardiorespiratory arrest (OHCA) make it a priority for all health systems worldwide. To increase the rates of potential first responders who act appropriately, applying basic life support (BLS) measures in the OHCA, the European Resuscitation Council includes among its latest recommendations the training of all school children through the \"Kids Save Lives\" initiative.\n\nObjectives: to determine, through a randomized clinical trial, the effectiveness of two training strategies for increasing theoretical and practical knowledge of BLS in schoolchildren and adolescents.\n\nMethodology: To evaluate the effectiveness of two (Cardiopulmonary Resuscitation) CPR teaching interventions in improving the following outcome variables: theoretical knowledge and practical skills, CPR quality; as well as its relationship with the anthropometric, sociodemographic and physical condition variables of the schoolers.\n\n* Intervention group 1 (IG1): a 2-hour theoretical-practical session on the BLS sequence taught by a Nursing professional performing the practice with a mannequin. Instructor\u002Fschool ratio: 1\u002F25 for the theoretical session and a school\u002Fmannequin ratio: 2-3\u002F1.\n* Intervention group 2 (IG2): a session with short video (approximately 5-10 min) and other teaching resources (puzzle), without practice on a mannequin. Video\u002Fschool ratio: 1\u002F25 and a school\u002Fteaching resource (puzzle) ratio: 1\u002F1.",[328,329,330,331,332],"Healthy Participants","Knowledge Acquisition","Cardiopulmonary Resuscitation (CPR)","Children","School","2025-12-05",{"date":308,"type":40},{"date":336,"type":40},"2025-09-15",{"date":338,"type":21},"2026-07-01",{"name":46,"class":47},2,{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":347,"eligibilityCriteria":348,"healthyVolunteers":278,"sex":17,"minAge":83,"maxAge":349,"enrollmentInfo":350,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":352,"conditions":353,"keywords":355,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":4},"100599975","promoting-motor-development-in-infants-and-toddlers-through-education-and-early-detection-100599975","NCT07091474","Promoting Motor Development in Infants and Toddlers Through Education and Early Detection","Little Movers: Promoting Motor Development in Early Childhood Through Educational and Therapeutic Interventions","Little-Movers","Inclusion Criteria (Workshops):\n\nLegal guardians or primary caregivers of children aged 0 to 36 months enrolled in the participating daycare center. Early childhood educators working with children aged 0 to 36 months in the same center.\n\nInclusion Criteria (Observational Study):\n\nInfants aged 0 to 12 months enrolled in the participating daycare center. Infants must not have a diagnosed neuromotor or neurological condition at the time of enrollment. Written informed consent must be obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\nChildren with diagnosed neurological or genetic conditions affecting motor development. Families or educators who decline participation or do not provide informed consent. Children or families not enrolled in the participating daycare center.","36 Months",{"count":351,"type":21},80,"The \"Little Movers\" study promotes healthy motor development in early childhood by providing education to caregivers and professionals in the child's environment and by implementing early detection strategies for motor delays.\n\nThe primary prevention component includes structured educational workshops designed for three age groups: 0-12 months, 13-24 months, and 25-36 months. These workshops focus on typical motor milestones, the importance of active play, early stimulation strategies, and how to recognize early warning signs of motor development delays. Participation impact will be measured using pre- and post-workshop surveys and semi-structured interviews with parents, caregivers, and educators.\n\nThe secondary and tertiary prevention component consists of a longitudinal observational study that follows infants aged 0 to 12 months. Motor development will be assessed using validated tools, including the Standardized Infant Hand Assessment (s-HAI), the Hammersmith Infant Neurological Examination (HINE), the Infant Motor Profile (IMP), and the Ages and Stages Questionnaire (ASQ-3). Infants with typical development will be reassessed annually, while those at risk or showing signs of motor delay will be monitored monthly. The goal is to detect motor delays as early as possible to allow timely referral and intervention.",[354],"Typical Development",[356,357,358,260,359],"motor development","education","prevention","early age","2025-07-21",{"date":362,"type":40},"2025-07-29",{"date":364,"type":21},"2025-09-01",{"date":366,"type":21},"2027-09-01",{"name":46,"class":47},{"id":369,"slug":370,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":372,"acronym":373,"eligibilityCriteria":374,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":375,"targetDuration":4,"studyType":22,"phases":377,"briefSummary":378,"conditions":379,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":4},"100594850","effect-of-nurse-assessed-remote-ischemic-preconditioning-on-improving-exercise-capacity-endothelial-function-and-arterial-stiffness-in-patients-with-heart-failure-with-preserved-ejection-fraction-100594850","NCT07024810","Effect of Nurse-assessed Remote Ischemic Preconditioning on Improving Exercise Capacity, Endothelial Function, and Arterial Stiffness in Patients With Heart Failure With Preserved Ejection Fraction","PIRIC-FEp Stud","Inclusion Criteria:\n\n1. HF-PEF (diagnosis according to the ESC 2021 criteria)\n\n   1. Signs and symptoms of HF\n   2. A left ventricular ejection fraction ≥50%.\n   3. Objective evidence of cardiac structural and\u002For functional abnormalities consistent with the presence of left ventricular diastolic dysfunction\u002Felevated left ventricular filling pressures, including elevated natriuretic peptides\n2. Sedentary men and women (structured exercise \\\u003C2 x 30 min\u002Fweek).\n3. Age ≥40 years\n4. Written informed consent\n5. Clinically stable for 6 weeks\n6. Optimal medical treatment for ≥6 weeks.\n\nExclusion Criteria:\n\n1. Non-cardiac causes of HF symptoms:\n\n   * Significant valvular or coronary artery disease\n   * Uncontrolled hypertension or arrhythmias\n   * Primary cardiomyopathies\n2. Significant pulmonary disease (FEV1\\\u003C50% predicted, GOLD III-IV)\n3. Inability to exercise or conditions that may interfere with exercise intervention.\n4. Myocardial infarction within the last 3 months.\n5. Patients with diabetes and\u002For peripheral vascular disease.\n6. Signs of ischemia during maximal cardiopulmonary stress test.\n7. Comorbidity that may influence prognosis at one year.\n8. Participation in another clinical trial",{"count":376,"type":21},48,[24],"The PIRIC-FEp study will be a randomized clinical trial in sedentary patients with heart failure and stable preserved ejection fraction.\n\nObjectives: 1) To evaluate the efficacy of remote ischemic preconditioning performed by nurses, a noninvasive cardioprotective intervention that uses cycles of ischemia and reperfusion in the extremities, in improving exercise capacity, cardiac function, endothelial function and arterial stiffness, and 2) To analyze its impact on quality of life and its cost-effectiveness compared to conventional treatment.\n\nMethodology: Patients will be recruited in Health Centers in the city. Those assigned to the intervention group will wear a self-administered blood pressure cuff, inflated to 220 mmHg for 5 minutes, followed by 5 minutes of deflation, in repeated cycles four times, five days a week for three months. The control group will receive standard counseling. All participants will be examined, at baseline and at three months. Adherence will be defined as completing at least 70% of the sessions. Different parameters will be evaluated, including sociodemographic variables, patient's medical history, echocardiography, cardiopulmonary exercise test, endothelial function, arterial stiffness, quality of life, spirometry, blood tests, among others. The study will be approved by an Ethics Committee, participants will be informed and will have to sign a written consent. The statistical analysis will include three phases: verification of randomization, use of covariance models for dependent variables, and sensitivity analysis with propensity score matching. All analyses will be performed on an intention-to-treat basis.",[380],"HF - Heart Failure","2025-06-09",{"date":383,"type":40},"2025-06-17",{"date":385,"type":21},"2025-10-01",{"date":387,"type":21},"2027-02-28",{"name":46,"class":47},{"id":390,"slug":391,"hasResults":11,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":395,"eligibilityCriteria":396,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":397,"targetDuration":4,"studyType":22,"phases":399,"briefSummary":400,"conditions":401,"keywords":404,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":340},"100591888","tdcs-combined-with-treadmill-training-in-patients-with-multiple-sclerosis-100591888","NCT06986278","tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis","Transcranial Direct Current Stimulation Combined With Treadmill Training With Partial Body Weight Support in Patients With Multiple Sclerosis","TDCS","Inclusion Criteria:\n\n* Ability to understand and follow instructions.\n* Diagnosis of Multiple Sclerosis according to McDonald criteria.\n* Expanded Disability Status Scale (EDSS) between 1 and 6.\n* Stable condition in the last three months.\n\nExclusion Criteria:\n\n* Peripheral neurological injury of lower limbs.\n* Metal objects in the head.\n* Uncontrolled epilepsy.\n* Diagnosis of psychiatric disorder.\n* Fractures or fissures in the skull.\n* Presence of any implanted electronic device (pacemaker, baclofen pump).\n* Presence of ulcers in the harness attachment area.\n* Osteoporotic fractures in the last 2 years.\n* Height \\> 190 cm.\n* Weight \\> 120 kg.",{"count":398,"type":21},78,[24],"This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.",[402,403],"tDCS","Sham tDCS",[405,406,407,408],"tdcs","gait","multiple sclerosis","gait training","2025-05-22",{"date":411,"type":40},"2025-05-29",{"date":413,"type":21},"2025-05-26",{"date":415,"type":21},"2025-12-31",{"name":46,"class":47},{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":421,"acronym":422,"eligibilityCriteria":423,"healthyVolunteers":278,"sex":17,"minAge":424,"maxAge":425,"enrollmentInfo":426,"targetDuration":4,"studyType":22,"phases":428,"briefSummary":429,"conditions":430,"keywords":437,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":456,"leadSponsor":458,"locationsCount":4},"100588270","analysis-of-new-materials-and-artificial-turf-products-influence-and-impact-on-athlete-performance-and-perception-100588270","NCT06939218","Analysis of New Materials and Artificial Turf Products: Influence and Impact on Athlete Performance and Perception","ANMATT","Inclusion Criteria: Gender: Male or female football players. Experience: Players who have played football for at least one full season prior to participating in the study.\n\nPlaying Level: Players who have played at the base or amateur level for at least 6 years.\n\nHealth Status: Players who do not have active or chronic injuries that could affect their ability to perform performance tests.\n\nWillingness to Participate: Players who are willing to undergo performance tests and complete perception questionnaires.\n\nRecent Injury History: Players who have not experienced significant injuries in the three months prior to the start of the study.\n\nMedical Conditions: Players who do not have pre-existing medical conditions that could affect their ability to perform performance tests or endanger their health during the tests.\n\nMedication: Players who are not taking medications that could affect their ability to perform performance tests.\n\nConsent: Players who have signed an informed consent form to participate in the study and are willing to consistently follow the study protocols.\n\nAge: Players between 20 and 30 years old (to obtain a more homogeneous sample). -\n\nExclusion Criteria: Recent Injury: Players who have experienced a significant injury in the last three months that required medical attention or could affect their ability to perform performance tests.\n\nChronic Illness: Players who have a chronic illness that could affect their ability to perform performance tests.\n\nMedication: Players who are taking medications that could affect their ability to perform performance tests or could affect their understanding of the questionnaires and perception tools.\n\nMedical History: Players who have a history of cardiovascular, pulmonary, or neurological disease.\n\nRecent Surgery: Players who have had major surgery in the last six months that could affect their ability to perform performance tests.\n\nProtocol Compliance: Players who are not willing or able to consistently follow the study protocols.\n\nDisability: Players who have a physical or cognitive disability that could affect their ability to perform performance tests.\n\nConsent: Players who have not signed an informed consent form to participate in the study.\n\nAge: Players who do not meet the minimum and maximum age requirements to be included in the study.\n\n\\-","20 Years","30 Years",{"count":427,"type":21},30,[24],"This request pertains to a series of related projects on a common theme. Specifically, this set of projects aims to analyze the impact of new alternatives in materials and structures of artificial turf on athlete performance and perception, within the context of the elimination of microplastics as per Commission Regulation (EU) 2023\u002F2055 of September 25, 2023. Third-generation sports artificial turf is notable for including performance infill (granules) that provide the necessary functionality and safety for sports practice. The vast majority of fields worldwide use materials that do not comply with the new European regulation, which has granted an eight-year moratorium. Therefore, there is little time to find new alternatives. The challenge lies not only in developing new structural solutions but also in understanding their impact on athletes. This issue is of high severity, as these sports facilities are the largest in terms of space and host the highest number of Physical Activity and Sports practitioners in Europe (mainly Football, Rugby, Hockey, and Padel).\n\nFor this reason, over the past year, the IGOID Group has requested various projects to cover all the necessary phases and nuances to address this issue.\n\nThe activities included in these projects are divided into two phases:\n\nPhase 1: Evaluation of Sports Surfaces in the Laboratory (durability and surface-player and surface-ball interaction). Tests will be conducted on artificial turf samples constructed with SBR rubber (the main material to be replaced under the EU regulation), natural-origin infills, polymeric infills larger than 5 mm, and other infills. Initially, a market analysis and classification will be carried out, followed by laboratory tests. Across all projects, a minimum of 30 alternatives are expected to be analyzed.\n\nPhase 2: Field Study. Tests will be conducted on a sample of athletes on constructed surfaces representing the different alternatives evaluated in Phase 1. Performance tests and a battery of assessments will be carried out to understand athlete perception. A sample of 30 athletes will be randomly divided into groups to perform different repetitions of the test batteries, covering a minimum of six different sports facilities.",[431,432,433,434,435,436],"Artificial Turf","Athletic Performance and Injury Risk","Physical Fitness","Sports Equipment","Microplastics","Healthy",[431,438,433,434,435,439,440,441,442,443,444,445,446,447,448,449,450,451],"Athletic Performance","Environmental Impact","Athlete Perception","Field Studies","Laboratory Testing","Synthetic Materials","Natural Materials","Polymer Infills","Durability","Safety","Functional Performance","Regulation Compliance","Third-Generation Turf","Football (Soccer)","2025-04-14",{"date":454,"type":40},"2025-04-22",{"date":364,"type":21},{"date":457,"type":21},"2026-06-30",{"name":46,"class":47},{"id":460,"slug":461,"hasResults":11,"nctId":462,"briefTitle":463,"officialTitle":463,"acronym":4,"eligibilityCriteria":464,"healthyVolunteers":278,"sex":17,"minAge":18,"maxAge":218,"enrollmentInfo":465,"targetDuration":4,"studyType":22,"phases":467,"briefSummary":468,"conditions":469,"keywords":479,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":485,"lastUpdatePostDateStruct":486,"startDateStruct":488,"completionDateStruct":490,"leadSponsor":491,"locationsCount":4},"100586867","recovery-optimization-intervention-to-reduce-the-risk-of-injuries-in-soccer-players-100586867","NCT06920966","Recovery Optimization Intervention to Reduce the Risk of Injuries in Soccer Players","Inclusion Criteria:\n\nAge: Participants must be adults (18 years or older). Gender: Both male and female participants are eligible. Sport: Participants must be amateur football players. Team Membership: Participants must be members of a football team in the Castilla-La Mancha regional category.\n\nConsent: Participants must provide written informed consent to participate in the study.\n\nHealth: Participants must be in good general health, with no chronic illnesses or conditions that would contraindicate participation in physical activity or water immersion.\n\nExclusion Criteria:\n\nInjury: Participants who have sustained an injury that prevents them from participating in football activities for at least two weeks during any of the study blocks.\n\nMedical Conditions: Participants with medical conditions that contraindicate water immersion (e.g., severe cardiovascular conditions, open wounds, skin infections).\n\nWithdrawal: Participants who choose to withdraw from the study at any point. Non-compliance: Participants who do not comply with the study protocol or fail to attend scheduled sessions.\n\nPregnancy: Female participants who are pregnant or planning to become pregnant during the study period.",{"count":466,"type":21},25,[24],"The goal of this clinical trial is to evaluate if recovery interventions using cold and hot water immersion can reduce the risk of injuries in amateur soccer players.\n\nThe main questions it aims to answer are:\n\nDo cold water immersions reduce muscle fatigue and improve performance more effectively than hot water immersions? What is the optimal timing and duration for these recovery interventions to maximize their effectiveness?\n\nResearchers will compare:\n\nCold Water Immersion (CWI) Hot Water Immersion (HWI) No Immersion (NI) Thermographic Immersion (TI) based on individual thermal profiles\n\nParticipants will:\n\nUndergo thermographic assessments to determine their thermal profiles. Perform physical tests such as isometric strength tests, countermovement jumps (CMJ), and squats with 50% body weight.\n\nComplete wellness questionnaires to assess their subjective recovery and fatigue levels.\n\nProvide blood and urine samples for biomarker analysis. Participate in recovery interventions (CWI, HWI, or TI) based on their assigned group.",[470,471,472,473,474,475,476,477,478],"Muscle Fatigue (C23.888.592.612.612)","Athletic Injuries (C26.857.500.124)","Recovery of Function (G11.427.698.620)","Cryotherapy (E02.095.301.250)","Thermotherapy (E02.095.301.750)","Soccer (I03.450.642.845.750)","Biomarkers (D23.050.301)","Thermography (E01.370.350.700.750)","Physical Fitness (G11.427.410.698)",[480,481,482,483,484],"Muscle Fatigue","Recovery Interventions","Fatigue Reduction","Recovery Optimization","Physical Performance","2025-04-02",{"date":487,"type":40},"2025-04-10",{"date":489,"type":21},"2025-05-01",{"date":364,"type":21},{"name":46,"class":47},{"id":493,"slug":494,"hasResults":11,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":11,"sex":17,"minAge":425,"maxAge":499,"enrollmentInfo":500,"targetDuration":4,"studyType":22,"phases":502,"briefSummary":503,"conditions":504,"keywords":507,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":515,"completionDateStruct":516,"leadSponsor":518,"locationsCount":48},"100580540","redcord-in-neurogenic-bowel-dysfunction-in-multiple-sclerosis-100580540","NCT06838624","RedCord in Neurogenic Bowel Dysfunction in Multiple Sclerosis","Effectiveness of Treatment With RedCord in Neurogenic Bowel Dysfunction in People With Multiple Sclerosis","Inclusion Criteria:\n\n* People diagnosed with Multiple Sclerosis according to McDonald's criteria.\n* EDSS less than 6 points.\n* Willingness to participate.\n\nExclusion Criteria:\n\n* People with cognitive impairment, which makes it difficult to understand the questionnaires properly.\n* Pregnant women.\n* Severe psychological or psychiatric pathology diagnosed.","60 Years",{"count":501,"type":21},76,[24],"The study aims to evaluate the effectiveness of Redcord treatment for neurogenic bowel dysfunction in patients with multiple sclerosis. The main objectives are:\n\n* Assess the impact of Redcord on bowel function and quality of life in multiple sclerosis patients.\n* Compare the outcomes of Redcord treatment with standard care practices.\n\nParticipants will undergo Redcord therapy sessions and their bowel function will be monitored and compared to a control group receiving standard care. The study will measure improvements in bowel control, frequency, and overall patient satisfaction.",[505,506],"Multiple Sclerosis","Pelvic Floor Disorder",[505,508,509,510,511],"Constipation","Faecal Incontinence","Pelvic Floor","Abdominal Muscles","2025-02-20",{"date":514,"type":40},"2025-02-24",{"date":364,"type":21},{"date":517,"type":21},"2026-12-15",{"name":46,"class":47},{"id":520,"slug":521,"hasResults":11,"nctId":522,"briefTitle":523,"officialTitle":524,"acronym":4,"eligibilityCriteria":525,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":526,"enrollmentInfo":527,"targetDuration":4,"studyType":22,"phases":528,"briefSummary":529,"conditions":530,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":4},"100532580","diastasis-recti-abdominis-and-a-combined-treatment-with-abdominal-exercise-and-radiofrequency-100532580","NCT06214650","Diastasis Recti Abdominis and a Combined Treatment With Abdominal Exercise and Radiofrequency","Efficacy of a Combined Treatment With Abdominal Exercise and Radiofrequency in Postpartum Women With Diastasis Recti Abdominis","Inclusion Criteria:\n\n* Women diagnosed with diastasis recti abdominis (DRA)\n* Age range18-45 years old\n* Women not DRA treated previously\n* Women not diagnosed with umbilical hernia\n\nExclusion Criteria:\n\n* DRA width less than 2.5cm\n* Women diagnosed with intestinal disease such as irritable bowel syndrome (IBS) or Chron disease.\n* Women looking for a new pregnancy or pregnant women.\n* Women who can not receive diathermy treatment (e.g tumoral process, open wound in the abdominal area or any diathermy contraindication).","45 Years",{"count":59,"type":21},[24],"Diastasis recti abdominis is a pathology that appears in a high percentage of women during the postpartum period. However, there is little evidence about its treatment. The present protocol aims to evaluate the efficacy of radiofrequency as an alternative for the treatment of abdominal diastasis along with abdominal exercises compared to the only intervention through abdominal exercise.\n\nAn aleatory clinical testing will be conducted where 44 women diagnosed with diastasis recti abdominis in the postpartum period will be recruited. A common exercise protocol will be applied for two groups of participants, and both of them will have to be able to carry out the activities autonomously at home. In addition, control sessions will be held weekly for both groups where one of the groups, the control group (n=22), will receive radiofrequency therapy with the machine in athermic mode, while the other group, the experimental group (n=22), will receive a weekly session under the established diathermy protocol. The sessions will last 30 minutes and will take place for 10 consecutive weeks.\n\nThree variables will be evaluated: the width of the diastasis measured in centimeters, life quality measured using the Short form (36) questionnaire, and the perception of the pain measured with the visual analogue scale. Three evaluations will be done: at the beginning of the study, after ten weeks and three months later.",[531,532,533,534],"Diastasis","Diastasis Recti","Diastasis Recti and Weakness of the Linea Alba","Diastasis Recti Abdominis","2024-05-07",{"date":537,"type":40},"2024-05-08",{"date":539,"type":21},"2024-09",{"date":541,"type":21},"2029-12",{"name":46,"class":47},{"id":544,"slug":545,"hasResults":11,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":278,"sex":17,"minAge":168,"maxAge":4,"enrollmentInfo":551,"targetDuration":553,"studyType":171,"phases":4,"briefSummary":554,"conditions":555,"keywords":561,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":566,"startDateStruct":567,"completionDateStruct":569,"leadSponsor":570,"locationsCount":48},"100375838","movement-and-behaviours-measurement-study-100375838","NCT04173715","Movement and Behaviours Measurement Study","Validation of Cut-points to Estimate Sedentary Time and Physical Activity Intensities in Older Adults","MOBEMENTS","Inclusion Criteria:\n\n* 65 years and older\n* Non-institutionalized\n* Physical function assessment (SPPB\\>3)\n\nExclusion Criteria:\n\n* Have started an exercise program.\n* Mini-Mental Score \\\u003C 18.\n* Presenting any physical activity contraindication.",{"count":552,"type":21},90,"1 Day","There are few studies that already have validated specific raw accelerometer cut-points for people over 65 years old.\n\nThe purpose of the present study is to validate raw accelerometer cut points for general people over 65 years old and specific raw accelerometer cut points based on the functional status of older adults over 65 years old.\n\nThe study will be carried out with an observational approach. Participants will be divided into 4 groups. First of them will be made grouping all subjects and the rest divided according to their functional status. They will perform different-intensity physical activities while wearing accelerometers attached to their body and wearing a portable gas analyser too. Their intensity will be assessed based on their own Rest Metabolic Rate (RMR). Energy expenditure and accelerations will be matched and, based on that, sedentary behaviour, light physical activity and moderate-to-vigorous physical activity cut-points will be derived.",[556,557,558,559,560],"Aging","Physical Function","Frailty Syndrome","Physical Disability","Lifestyle, Sedentary",[562,563,564,557,558,565,556],"Cut-Points","Accelerometry","Physical Activity Quantification","Energy Expenditure",{"date":537,"type":40},{"date":568,"type":40},"2019-10-14",{"date":137,"type":21},{"name":46,"class":47},""]