[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Catania\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":87},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,61],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100528723","auditory-functions-in-patients-with-multiple-sclerosis-100528723",false,"NCT06164483","Auditory Functions in Patients With Multiple Sclerosis","Electrophysiological Studies of Auditory Functions and CSF Analyses in Patients With Multiple Sclerosis","Inclusion Criteria\n\n* age \\>18 and \\\u003C50,\n* no history of hearing loss,\n* no psychiatric condition\n* no familial history of otosclerosis\u002Fdeafness\u002Fgenetic hearing loss\n* patients with PD and\u002For MS.\n\nExclusion Criteria\n\n* Conductive hearing loss\n* stroke \\\u003C 2 years\n* cardiovascular disease non under control\n* diabetes\n* hypotensive disorders\n* alcohol abuse\n* recreational drug consumption\n* epilepsy",true,"ALL","20 Years","40 Years",{"count":21,"type":22},30,"ESTIMATED","OBSERVATIONAL","The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission (DPOAE). CSF will be collected by lumbar puncture and analyzed looking for inflammatory markers.\n\nThe results of DPOAE and CSF will be correlated to identify statistically significant correlation.",[26,27],"Multiple Sclerosis","Hearing Disorders","RECRUITING","2026-05-11",{"date":31,"type":32},"2026-05-12","ACTUAL",{"date":29,"type":32},{"date":35,"type":22},"2028-12-30",{"name":37,"class":38},"University of Catania","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":16,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":52,"studyType":23,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":56,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":60,"locationsCount":39},"100517699","olfactory-and-trigeminal-functions-in-patients-with-multiple-sclerosis-case-control-study-100517699","NCT06020937","Olfactory and Trigeminal Functions in Patients With Multiple Sclerosis: Case-control Study","Olfactory and Trigeminal Functions in Patients With Multiple Sclerosis","Inclusion Criteria:\n\nAdult women (age 18 to 55) diagnosed with multiple sclerosis using the 2017 McDonald Criteria under treatment with Disease Modifying Therapy (DMTs) with or without trigeminal concerns, or newly diagnosed with MS\n\nExclusion Criteria:\n\n* Chronic rhinosinusitis with and without nasal polyposis; current allergic rhinitis; other nasal issues that lead to olfactory dysfunction\n* anamnestic COVID with incomplete recovery\n* Neurodegenerative disorders (Parkinson, Alzheimer, Fronto-temporal Dementia, cognitive impairment and brain vascular diseases)\n* History of stroke in the last three years\n* Depression or any psychiatric condition\n* intake of drugs with sedating side effects\n* major health issues that might affect olfactory function (e.g., significant renal insufficiency, uncontrolled diabetes)\n* Chronic alcoholism \u002F drug abuse\n* Severe head trauma\n* Severe facial injuries\n* Smoker over 20 cigarettes day or smoking from more than 15 years","FEMALE","18 Years","55 Years",{"count":51,"type":22},200,"12 Months","The sensation of smell is influenced by the somatosensory and chemesthetic sensati¬ons of the nose: for example, the cooling sensation of menthol or the prickle of carbon dioxide from carbonated drinks. These sensations are mediated in the nose by the trigeminal nerve and there is increasing evidence that trigeminal and olfactory functions are closely linked and potentially interdependent. In addition, trigeminal activation is crucial to the perception of nasal airflow. Some researchers speculate about the impact of trigeminal nerve on the entire olfactory sensation and about the presence of some specific \"trigeminal cells\" into the nose.Patients with Multiple sclerosis (MS) can suffer from quantitative olfactory disorders that generally are of light entity and do not interfere with daily life activities but it is important to underline that olfactory loss can be an onset sign of the MS. Considering the \"trigeminal component\" in the olfaction, because trigeminal nerve inflammation is quite common in MS patients due to central and peripheral inflammation, it could be possible that these patients suffer from changes in the quantitative, but more in the qualitative smell functions that are generally not identified because poorly investigated.",[26],"NOT_YET_RECRUITING",{"date":31,"type":32},{"date":58,"type":22},"2026-05-30",{"date":35,"type":22},{"name":37,"class":38},{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":4,"eligibilityCriteria":67,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":39},"100508929","impact-of-non-surgical-periodontal-therapy-in-the-improvement-of-early-endothelial-dysfunction-in-subjects-with-peri-implantitis-and-peri-implant-mucositis-100508929","NCT05906810","Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis","Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis: a Randomized-controlled Clinical Trial.","PERI-IMPLANTITIS GROUP\n\nInclusion Criteria:\n\n• Clinically diagnosed with peri-implantitis according to the EFP\u002FAAP 2017 criteria.\n\nExclusion Criteria:\n\n* Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months.\n* Pregnancy.\n* Cardiovascular Diseases.\n\nPERI-IMPLANT MUCOSITIS GROUP\n\nInclusion Criteria:\n\n• Clinically diagnosed with peri-implant mucositis according to the EFP\u002FAAP 2017 criteria.\n\nExclusion Criteria:\n\n* Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months.\n* Pregnancy.\n* Cardiovascular Diseases.\n\nHEALTHY GROUP\n\nInclusion Criteria:\n\n• Clinically diagnosed with healthy periodontum withouth periodontitis history according to the EFP\u002FAAP 2017 criteria.\n\nExclusion Criteria:\n\n* Scaling, antibiotics, NSAIDs, immunosuppressants during the last 6 months.\n* Pregnancy.\n* Cardiovascular Diseases.",{"count":69,"type":22},90,"INTERVENTIONAL",[72],"NA","A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis\u002Fperi-implant mucositis and without any cardiovascular disease.",[75,76,77,78],"Atherosclerosis","Endothelial Dysfunction","Peri-Implantitis","Peri-implant Mucositis","2025-05-18",{"date":81,"type":32},"2025-05-21",{"date":83,"type":32},"2020-10-05",{"date":85,"type":22},"2025-12-20",{"name":37,"class":38},""]