[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Child Health Sciences and Children's Hospital, Lahore\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":66},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100642072","phase-3-comparison-of-outcome-of-hypoxic-ischemic-encephlopathy-managed-with-combination-of-magnesium-sulphate-and-melatonin-versus-magnesium-sulphate-alone-100642072",false,"NCT07652801","COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHLOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE","COMPARISON OF OUTCOME OF HYPOXIC ENCEPHLOPATHY MANAGED WITH MgSO4 AND MELATONIN VERSUS MgSO4 ALONE","Inclusion Criteria:\n\n* Both genders\n* Born at term i.e \\>37weeks gestation\n* With APGAR score\\\u003C5 at 1min\n* Umblical artery acidemia(PH\\\u003C7 or base deficit\\>12mmol\u002FL\n* Evidence of atleast moderate grade ofHIE on sarnat scoring.\n\nExclusion Criteria:\n\n* With congenital anamolies\n* Intrauterine growth retadation\n* suspicion of neonatal sepsis\n* Congenital heart disese and those with IEM.","ALL","1 Hour","28 Days",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHALOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE Participants of group A will have 3 doses of MgSO4 infusion at rate of 250mg\u002Fkg per day intravenous over 1hour on day 0,1,2 Participants of group B will have 5 doses of Melatonin 10mg\u002Fkg for 5days along with MgSO4. They will undergo reassessment of arterial PH and serum LDH after completion of therapy. They will be followed for length of hospital stay and time until feed is initiated.",[27],"HIE - Hypoxic - Ischemic Encephalopathy","NOT_YET_RECRUITING","2026-06-11",{"date":31,"type":32},"2026-06-17","ACTUAL",{"date":34,"type":21},"2026-07-01",{"date":36,"type":21},"2026-12-31",{"name":38,"class":39},"University of Child Health Sciences and Children's Hospital, Lahore","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100585419","comparison-of-outcome-of-three-days-bowel-preparation-vs-no-bowel-preparation-in-patients-of-colostomy-reversal-100585419","NCT06902116","Comparison of Outcome of Three Days Bowel Preparation vs No Bowel Preparation in Patients of Colostomy Reversal","Inclusion Criteria:\n\n* Children with colostomy between 1-15 years of age\n\nExclusion Criteria:\n\n* Malnourished\n* Previous history of colostomy site anastomotic leakage","1 Year","15 Years",{"count":20,"type":21},[50],"NA","The goal of this trial is to compare the outcomes of colostomy reversal with three days bowel preparation with no bowel preparation in terms of anastomotic leakage, surgical site infection and hospital stay.\n\nThe important question this trial aims to answer is:\n\n1\\. is there any difference in outcomes after colostomy reversal with three days gut preparation pre-operatively vs no gut preparation?\n\nThis prospective Randomized Controlled trial will include children with colostomy divided into two groups:\n\nGroup A: No Mechanical Bowel Preparation Group B: 3 Days Mechanical Bowel Preparation Participants of Group A will be admitted 1 day prior to surgery date as they require no special preparation before surgery. They will be made Nil per oral 6 hours prior to surgery. Group B participants will be admitted 3 days prior to surgery. These participants will be restricted to fiber rich diet and milk 72 hours prior to surgery. They will be shifted to clear liquids 24 hours prior to surgery. Normal saline enema will be given 8 hourly through the stoma as well as per rectally by the trained person.\n\nComparative outcomes will be:\n\n1. Anastomotic leakage\n2. Hospital Stay\n3. Wound infection",[53,54,55],"Colostomy - Stoma","Bowel Preparation","BOWEL ANASTOMOSIS","RECRUITING","2025-03-27",{"date":59,"type":32},"2025-03-30",{"date":61,"type":32},"2025-01-08",{"date":63,"type":21},"2026-03",{"name":38,"class":39},1,""]