[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Crete\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":150},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,56,86,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100431190","phase-4-opioid-free-anesthesia-analgesia-strategy-and-surgical-stress-in-elective-open-abdominal-aortic-aneurysm-repair-100431190",false,"NCT04894864","Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study","Inclusion Criteria:\n\n1. Patient Consent\n2. Age between 40 and 85 years old\n3. Patients undergoing Elective Open Abdominal Aortic Infrarenal Aneurysm Repair\n\nExclusion Criteria:\n\n1. Immunocompromised patients\n2. Patients with active infection\n3. Reoperation on the aorta\n4. Inflammatory bowel Disease\n5. Malignancy\n6. Chronic Inflammatory conditions (e.g. Rheymatoid arthritis, Psoriatic arthritis)\n7. Chronic corticosteroid or immunosuppressive drug use\n8. Intraoperative transfusion with \\>2 units of packed Red Blood Cells","ALL","40 Years","85 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Open Abdominal Aortic Aneurysm (AAA) repair is a high-risk surgical procedure accompanied by intense endocrine and metabolic responses to surgical stress, with subsequent activation of the inflammatory cascade, cytokine and acute-phase protein release, and bone marrow activation. There is a proven correlation of surgical stress, which patients undergoing open AAA repair are subjected to, with patient outcome, morbidity\u002Fmortality, intensive care unit stay and overall length of stay. Modern general anesthetic techniques have been revised and rely on perioperative multimodal anesthetic and analgesic strategies for improved overall patient outcome. Based on this context of a multimodal anesthetic technique and having taken into consideration the international \"opioid-crisis\" epidemic, an Opioid Free Anesthesia-Analgesia (OFA-A) strategy started to emerge. It is based on the administration of a variety of anesthetic\u002Fanalgesic agents with different mechanisms of action, including immunomodulating and anti-inflammatory effects.\n\nOur basic hypothesis is that the implementation of a perioperative multimodal OFA-A strategy, involving the administration of pregabalin, ketamine, dexmedetomidine, lidocaine, dexamethasone, dexketoprofen, paracetamol and magnesium sulphate, will lead to attenuation of surgical stress response compared to a conventional Opioid-Based Anesthesia-Analgesia (OBA-A) strategy. Furthermore, the anticipated attenuation of the inflammatory response, is pressumed to be associated with equal or improved analgesia, compared to a perioperative OBA-A technique.",[27,28,29,30,31,32,33,34],"Elective Surgical Procedures","Postoperative Pain","Anesthesia","Opioid Use","Abdominal Aortic Aneurysm Without Rupture","Vascular Surgical Procedure","Interleukin 6","Immunomodulators",[36,37,38,39,40,41,42],"Opioid-free Anesthesia-Analgesia","Cytokines","Opioid-based Anesthesia-Analgesia","Haemodynamic Stability","Open Abdominal Aortic Aneurysm Repair","Immunomodulation","Inflammatory Markers","RECRUITING","2026-06-13",{"date":46,"type":47},"2026-06-16","ACTUAL",{"date":49,"type":47},"2020-10-08",{"date":51,"type":21},"2027-09-01",{"name":53,"class":54},"University of Crete","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":16,"minAge":64,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":69,"conditions":70,"keywords":76,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":55},"100612845","effect-of-vexus-ultrasound-protocol-venous-excess-ultrasound-on-perioperative-fluid-management-on-the-incidence-of-postoperative-pulmonary-complications-and-postoperative-acute-kidney-injury-in-patients-undergoing-thoracic-surgery-100612845","NCT07258875","Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery","VEXUS","Inclusion Criteria:\n\n* Adults \\>18 years undergoing video assisted thoracic surgery\u002F lobectomy requiring one-lung ventilation.\n\nExclusion Criteria:\n\n* Refusal to participate.\n* Pneumonectomy.\n* Young athletes (risk of physiologically large IVC \\>2 cm).\n* Moderate-severe tricuspid regurgitation, moderate to severe pulmonary hypertension\n* Heart failure with reduced ejection fraction, EF\\\u003C35%\n* Portal hypertension, portal vein thrombosis, or liver cirrhosis.\n* Stage 4 or end-stage chronic kidney disease (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m² or dialysis).\n* Transfusion with more than 2 packed red blood cells unit perioperatively (intraoperatively, in the PACU, in the ward)",true,"18 Years",{"count":66,"type":21},230,[68],"NA","This study aims to investigate the effect of a VExUS ultrasound guided protocol of perioperative fluid management within a goal-directed therapy framework, on postoperative respiratory complications, and the occurrence of acute kidney injury (AKI) in patients undergoing thoracic surgery.",[71,72,73,74,75],"Thoracic Surgery With One-lung Ventilation","VExUS","Fluid Management","Acute Kidney Injury","Postoperative Pulmonary Complications (PPCs)",[77],"VExUS, fluid management, pulmonary complications, acute kidney injury, thoracic surgery, one lung ventilation","2025-11-20",{"date":80,"type":47},"2025-12-02",{"date":82,"type":47},"2024-11-27",{"date":84,"type":21},"2029-11-01",{"name":53,"class":54},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":64,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":97,"conditions":98,"keywords":103,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":55},"100466701","electroacupuncture-pain-treatment-mechanical-hyperalgesia-quality-of-life--expression-of-mu-b-cells-in-fibromyalgia-100466701","NCT05357157","Electroacupuncture Pain Treatment, Mechanical Hyperalgesia, Quality of Life & Expression of Mu+ B Cells in Fibromyalgia","Effect of Electroacupuncture Treatment on Pain, Mechanical Hyperalgesia, Quality of Life and Expression of Mu+ B Cells in Patients With Fibromyalgia: A Prospective Observational Study","Inclusion Criteria:\n\n* Patient's consent\n* Age \\>18 years old\n* Patients with diagnosed fibromyalgia from rheumatologists\n* Widespread pain more than 6 months\n* In case of drug therapy, it should be taken at least one month before the beginning of the session and remain stable till the end of the study\n\nExclusion Criteria:\n\n* Deep depression\n* Biological agent use ( TNF inhibitors)\n* Heamatological diseases\n* Systemic Infections\n* pregnancy\n* electroacupuncture contraindications (epilepsy, pacemaker\u002F implantable cardioverter defibrillator (ICD)","80 Years",{"count":95,"type":21},80,"OBSERVATIONAL","Fibromyalgia (FM) is a complex, multifactorial syndrome characterized by widespread chronic pain with hyperal- gesia and allodynia and a constellation of somatic and psychological manifestations, including fatigue, sleep dis- orders, depression, anxiety, gastrointestinal and cognitive disorders. FM is now recognized as one of the most common chronic pain conditions and its management remains a challenge for patients and healthcare profes- sionals. The fact that FM is associated with chronic pain without any obvious peripheral tissue damage has given rise to the concept of nociplastic pain with evidence of dysfunction in mono-aminergic neurotransmission, lead- ing to elevated levels of excitatory neurotransmitters and decreased levels of serotonin and norepinephrine in the spinal cord at the level of descending anti-nociceptive pathways. Additionally, dopamine dysregulation and altered activity of endogenous cerebral opioids have been observed in FM.\n\nRecent European guidelines on FM treatment emphasize that there should be a comprehensive assessment of patient's pain, function and psychosocial context. It is recognized that there are profound and fundamental problems associated with the pain assessment tools in common use, as most of these represent an attempt to reduce a multidimensional experience to a coarse unidimensional measure. Use of multiple tools for sub- jective and objective assessment of pain may reflect more accurately patient's pain experience. Furthermore, tracing a biologic pain marker in FM patients would facilitate both the initial assessment of pain and the re- sponse to treatment. Management of pain in FM patients should focus first on non-pharmacological modalities. Acupuncture therapy is an effective and safe treatment and exerts its analgesic effect through activation of pe- ripheral and central pain control systems with the release of β-endorphins, enkephalins, dynorphins, serotonin, norepinephrine, γ-aminobutyric acid or ATP. The aim of our study is to assess initially reported pain and evaluate the effectiveness of electroacupuncture (with or without diet modifications) on the \"whole experience of pain\" in FM patients in a multimodel assessment frame.",[99,100,101,102],"Fibromyalgia","Electroacupuncture","Acupuncture","Hyperalgesia",[99,104,100,101,105,106,102,107,108,109,110],"Chronic Pain","Palmitoylethanolamide","MOR-Positive B Cell","Quality of life","Pressure Algometry","Anti-inflammatory Nutrition","Depression","2022-10-23",{"date":113,"type":47},"2022-10-26",{"date":115,"type":47},"2022-05-31",{"date":117,"type":21},"2026-12-01",{"name":53,"class":54},{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":64,"maxAge":93,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":136,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":55},"100452533","phase-4-opioid-free-anaesthesia-analgesia-strategy-on-surgical-stress-and-immunomodulation-in-elective-vats-lobectomy-for-nsclc-100452533","NCT05172739","Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","Effect of a Perioperative Opioid Free Anaesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response and Immunomodulation in Elective VATS Lobectomy for NSCLC Lung Cancer: A Prospective Randomized Study","Inclusion Criteria:\n\n* patients undergoing elective VATS lobectomy\n* early stage NSCLC (up to T3N1M0)\n\nExclusion Criteria:\n\n* Immunocompromised patients\n* previous lung surgery\n* preoperative corticosteroid or immunosuppressive drug use\n* uncontrolled Diabetes Mellitus\n* cardiac failure (NYHA 3 and 4)\n* preoperative infection (CRP \\>5mg\u002Fml, WBC \\>10x10\\^9\u002FL)\n* preoperative anemia (Hb\\\u003C12g\u002Fdl)\n* chronic inflammatory diseases\n* inflammatory bowel disease\n\nGroup-specific exclusion criteria:\n\n* OFA-Α: perioperative opioid administration, within the study period\n* OBA-Α: perioperative dexmedetomidine or lidocaine infusion, ketamine, gabapentinoid or corticosteroid administration within the study period",{"count":127,"type":21},70,[24],"Lobectomy is a major, high-risk surgical procedure that in addition to one-lung ventilation (OLV) exerts a potent surgical stress response. An overwhelming immune cell recruitment may lead to excessive tissue damage, peripheral organ injury and immunoparesis. The effect of anesthesia on the immune system is modest, compared to the effects induced by major surgery. However, to an immunocompromised patient, due to cancer and\u002For other comorbidities, the immunosuppressive effects of anesthesia may increase the incidence of post-operative infections, morbidity, and mortality. Exogenous opioids have been correlated with immunosuppression, opioid-induced hyperalgesia, and respiratory depression, with deleterious outcomes. An Opioid-Free Anaesthesia-Analgesia (OFA-A) strategy is based on the administration of a variety of anaesthetic\u002Fanalgesic and other pharmacological agents with different mechanisms of action, including immunomodulating and anti-inflammatory effects. Our basic hypothesis is that the implementation of a perioperative multimodal OFA-A strategy, will lead to an attenuated surgical stress response and attenuated immunosuppression, compared to a conventional Opioid-Based Anaesthesia-Analgesia (OBA-A) strategy. The aforementioned effects, are presumed to be associated with equal or improved analgesia and decreased incidence of postoperative infections compared to a perioperative OBA-A technique.",[131,132,133,134,30,29,135],"Systemic Inflammatory Response Syndrome","Postoperative Pain, Acute","Postoperative Pain, Chronic","Infections Postoperative","Non-small Cell Lung Cancer",[36,38,37,137,138,41,139,140,141],"NSCLC","Hemodynamic stability","Inflammatory markers","Acute postoperative pain","Chronic postoperative pain","2021-12-10",{"date":144,"type":47},"2021-12-29",{"date":146,"type":47},"2021-10-01",{"date":148,"type":21},"2026-11-01",{"name":53,"class":54},""]