[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Cyprus\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":239},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,48,74,99,124,149,181,211],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100641877","mitigation-of-health-effects-in-outdoor-workers-by-reducing-exposure-to-heat-and-air-pollution-100641877",false,"NCT07634952","Mitigation of Health Effects in Outdoor Workers by Reducing Exposure to Heat and Air Pollution","Innovative Solutions Across the MEDiterranean for Mitigation of Climate Change-related heaLth rIsks in Outdoor Workers","ISMED-CLIM OW","Inclusion Criteria:\n\n* 18-65 years old\n* Municipality outdoor workers\n* Regularly working outdoors for al least 6 hours per day\n* Living in León (Spain) or Trikala (Greece)\n* Clinically healthy\n* No history of diabetes mellitus type 2 (DM2)\n* No history of arterial hypertension\n\nExclusion Criteria:\n\n* Currently smoking\n* Presence of any smoking residents in the household\n* Not residing at the household for at least 5 days a week\n* Planning to move from the current home within the next two months\n* No access to Wi-Fi or 4G\u002F5G mobile phone\n* Severe chronic conditions (congestive heart failure, ischemic heart disease, significant valvular heart disease, DM2, inflammatory diseases, renal failure, or active cancer)\n* Drugs abuse\n* Alcohol abuse\n* Psychiatric disorders\n* Severe mental disability that interferes with answering questions or following instructions",true,"ALL","18 Years","65 Years",{"count":22,"type":23},102,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health effects in outdoor workers.\n\nThe main questions it aims to answer are:\n\n* Does the intervention (combination of behavioral recommendations for heat mitigation) reduce personal ambient temperature exposure, measured using a wearable device (iButton)?\n* Does the intervention (combination of behavioral recommendations for air pollution mitigation and use of indoor air cleaners) reduce indoor exposure to air pollution, measured using indoor air quality sensors (Purple Air)?\n* Does the intervention (combination of behavioral recommendations for heat mitigation) reduce physiological strain experienced by individuals working in hot environments, measured using the Heat Strain Score Index?\n\nResearchers will compare measurements between outdoor workers carrying out their activities in the absence of intervention (control group), those carrying out their activities with behavioural recommendations (recommendation intervention group) and those carrying out their activities with both behavioural recommendations for heat mitigation and continuous use of indoor air cleaners in their house (heat and air pollution mitigation intervention group) to see if changes in temperature exposure and physiological strain are different between intervention groups.\n\nParticipants will:\n\n* Wear the wearable devise for continuous personal ambient temperature monitoring (ibutton) daily for a period of three months\n* Have their core temperature measured using an eCelsius medical capsule in three repeated assessments\n* Complete the Heat Strain Score Index questionnaire in three repeated assessments\n* Provide samples of urine, blood, saliva and hair for measurement of various biomarkers in three repeated assessments",[29],"Heat Strain",[31,32,33,34],"outdoor workers","heat strain","intervention","personal ambient temperature exposure","RECRUITING","2026-06-12",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":39},"2026-05-01",{"date":43,"type":23},"2027-07-31",{"name":45,"class":46},"University of Cyprus","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":17,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":72,"locationsCount":73},"100638347","mitigation-of-health-effects-in-pregnant-women-by-reducing-exposure-to-heat-and-air-pollution-100638347","NCT07609433","Mitigation of Health Effects in Pregnant Women by Reducing Exposure to Heat and Air Pollution","Innovative Solutions Across the MEDiterranean for Mitigation of Climate Change-related heaLth rIsks and Enhancing Health systeM Resilience in Pregnant Women","ISMED CLIM PW","Inclusion Criteria:\n\n* Pregnant Women (PW) aged 20 to 35 years\n* being in the 2nd trimester of a singleton pregnancy (15th-27th week of gestation)\n* Living in Catania (Italy) or Limassol (Cyprus) districts\n* Clinically healthy\n* No Gestational diabetes\n* No pre-eclampsia\n* No severe pregnancy complications\n\nExclusion Criteria:\n\n* Currently smoking\n* Presence of any smoking residents in the household\n* Not residing at the household for at least 5 days a week\n* Planning to move from the current home within the next two months\n* No access to Wi-Fi or 4G\u002F5G mobile phone\n* Severe chronic conditions (congestive heart failure, ischemic heart disease, significant valvular heart disease, DM2, inflammatory diseases, renal failure, or active cancer)\n* Drugs abuse\n* Alcohol abuse\n* Psychiatric disorders\n* Severe mental disability that interferes with answering questions or following instructions","FEMALE","20 Years","35 Years",{"count":22,"type":23},[26],"The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health effects in pregnant women.\n\nThe main questions it aims to answer are:\n\n* Does the intervention (combination of behavioral recommendations for heat mitigation) reduce personal ambient temperature exposure, measured using a wearable device (iButton)?\n* Does the intervention (combination of behavioral recommendations for air pollution mitigation and use of indoor air cleaners) reduce indoor exposure to air pollution, measured using indoor air quality sensors (Purple Air)?\n* Does the intervention (combination of behavioral recommendations for heat mitigation) reduce sleep difficulties experienced by pregnant women, measured using the Pittsburgh Sleep Quality Index?\n\nResearchers will compare measurements between pregnant women carrying out their daily activities in the absence of intervention (control group), those carrying out their daily activities with behavioural recommendations (recommendation intervention group) and those carrying out their daily activities with both behavioural recommendations for heat mitigation and continuous use of indoor air cleaners in their house (heat and air pollution mitigation intervention group) to see if changes in temperature exposure and sleep are different between intervention groups.\n\nParticipants will:\n\n* Wear the wearable devise for continuous personal ambient temperature monitoring (ibutton) daily for a period of three months\n* Have their core temperature measured using an eCelsius medical capsule in three repeated assessments\n* Complete the Pittsburgh Sleep Quality Index questionnaire in three repeated assessments\n* Provide samples of urine and blood biomarkers in three repeated assessments.",[63],"Sleep Quality",[65,33,66,34],"Pregnancy","Sleep quality","2026-06-03",{"date":69,"type":39},"2026-06-05",{"date":41,"type":39},{"date":43,"type":23},{"name":45,"class":46},3,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":24,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":98,"locationsCount":47},"100639405","mitigation-of-health-effects-in-older-adults-with-hypertension-by-reducing-exposure-to-heat-and-air-pollution-100639405","NCT07606859","Mitigation of Health Effects in Older Adults With Hypertension by Reducing Exposure to Heat and Air Pollution","Innovative Solutions Across the MEDiterranean for Mitigation of Climate Change-related heaLth rIsks and Enhancing Health systeM Resilience","ISMED CLIM OH","Inclusion Criteria:\n\n* Aged ≥65 years\n* Living in Barcelona (Spain) or Nicosia (Cyprus) metropolitan areas\n* Have a physician's diagnosis of arterial hypertension\n* Receive daily anti-hypertensive medication\n* Clinically stable\n\nExclusion Criteria:\n\n* Currently smoking\n* Presence of any smoking residents in the household\n* Not residing at the household for at least 5 days a week\n* Planning to move from the current home within the next two months\n* No access to Wi-Fi or 4G\u002F5G mobile phone\n* Severe chronic conditions (congestive heart failure, ischemic heart disease, significant valvular heart disease, diabetes mellitus type 2 (DM2), inflammatory diseases, renal failure, or active cancer)\n* Illicit drugs abuse\n* Alcohol abuse\n* Psychiatric disorders\n* Severe mental disability that interferes with answering questions or following instructions",{"count":22,"type":23},[26],"The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health effects in older adults with hypertension.\n\nThe main questions it aims to answer are:\n\n* Does the intervention (combination of behavioral recommendations for heat mitigation) reduce personal ambient temperature exposure, measured using a wearable device (iButton)?\n* Does the intervention (combination of behavioral recommendations for air pollution mitigation and use of indoor air cleaners) reduce indoor exposure to air pollution, measured using indoor air quality sensors (Purple Air)?\n* Does the intervention (combination of behavioral recommendations for heat mitigation) improve the abnormalities in circadian blood pressure variation experienced by older adults with hypertension, assessed using advanced actigraphy? Researchers will compare measurements between older adults with hypertension carrying out their daily activities in the absence of intervention (control group), those carrying out their daily activities with behavioural recommendations (recommendation intervention group) and those carrying out their daily activities with both behavioural recommendations for heat mitigation and continuous use of indoor air cleaners in their house (heat and air pollution mitigation intervention group) to see if changes in temperature exposure and sleep are different between intervention groups.\n\nParticipants will:\n\n* Wear the wearable devise for continuous personal ambient temperature monitoring (ibutton) daily for a period of three months\n* Have their core temperature measured using an eCelsius medical capsule in three repeated assessments\n* Have their blood pressure, oxygen saturation, ECG and heart rate variability measured using 24-hour advanced actigraphy in three repeated assessments\n* Provide samples of urine and blood biomarkers in three repeated assessments.",[86,87],"Hypertension Arterial","65 Years Older",[89,90,91,92,93,94],"Hypertension","Adults 65 years and older","Intervention","Personal Ambient Temperature Exposure","Indoor air quality","Indoor air purification",{"date":69,"type":39},{"date":41,"type":39},{"date":43,"type":23},{"name":45,"class":46},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":24,"phases":108,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},"100631707","physiotherapy-after-emergency-laparotomy-in-the-elderly-100631707","NCT07504185","Physiotherapy After Emergency Laparotomy in the Elderly","Effect of Postoperative Physiotherapy on Postoperative Outcomes of Elderly Patients Undergoing Emergency Laparotomy","Inclusion Criteria:\n\n* Patients aged ≥ 65 years\n* Undergoing emergency laparotomy with or without stoma creation (adhesiolysis, right hemicolectomy, total colectomy, Hartmann's procedure, cholecystectomy, abscess drainage).\n\nAble to provide informed consent or have a legally authorized representative provide consent.\n\nAble to maintain an upright standing position for at least one minute with minimal or no assistance.\n\nExclusion Criteria:\n\n* Patients with Dementia (Abbreviated Mental Test Score \\\u003C 6)\n* Pre-existing severe disabilities affecting mobility\n* Patients with contraindications to physiotherapy (e.g., severe cardiopulmonary instability)\n* Patients transferred postoperatively from other hospitals\n* Patients who underwent no intervention during laparotomy (negative laparotomies)\n* Patients undergoing palliative procedures and at the end of life",{"count":107,"type":23},250,[26],"Emergency laparotomy is associated with high postoperative morbidity and mortality. This risk is particularly high among elderly patients, who often present with reduced physiological reserve, frailty, and multimorbidity.\n\nThe aim of this study is to evaluate the effect of a structured postoperative physiotherapy program in patients aged 65 years and older undergoing emergency laparotomy. The study will assess its impact on functional recovery and clinical outcomes.",[111],"Emergency Abdominal Surgery",[113,114],"postoperative recovery, elderly, emergency abdominal surgery","Physiotherapy intervention","2026-03-25",{"date":117,"type":39},"2026-03-31",{"date":119,"type":39},"2025-07-13",{"date":121,"type":23},"2028-05-31",{"name":45,"class":46},1,{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":56,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":24,"phases":136,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":123},"100555870","brain-research-and-integrative-neuroscience-network-for-covid-19-100555870","NCT06517706","Brain Research and Integrative Neuroscience Network for COVID-19","Brain Research and Integrative Neuroscience Network for COVID-19 (BRAINN)","BRAINN","Inclusion Criteria:\n\n* Reported cognitive difficulties due to COVID-19 infection\n* WHO Long COVID criteria will be used\n\nExclusion Criteria:\n\n* Significant history of neuropsychiatric conditions prior to contracting COVID-19; history of neurological conditions such as TBI, CVA, MS prior to contracting COVID-19.","25 Years","60 Years",{"count":135,"type":23},70,[26],"The aim of the experimental study is to investigate two interventions for the management of cognitive symptoms resulting from long COVID. Participants will be randomly assigned into two interventions. 1. Categorization Program (CP) training with active tDCS or 2. Categorization Program training with sham tDCS.",[139,140],"Cognitive Training","Transcranial Direct Current Stimulation","2024-12-03",{"date":143,"type":39},"2024-12-06",{"date":145,"type":39},"2024-11-15",{"date":147,"type":23},"2025-12-31",{"name":45,"class":46},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":133,"enrollmentInfo":157,"targetDuration":4,"studyType":159,"phases":4,"briefSummary":160,"conditions":161,"keywords":168,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":123},"100552307","unraveling-the-genetic-basis-of-nicotine-addiction-for-novel-therapeutic-strategies-100552307","NCT06471387","Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies","Exploring the Genetic and Molecular Underpinning of Nicotine Addiction for the Development of New Therapeutic Strategies","NicoGen","Inclusion Criteria:\n\n* Adults aged 18-60 years old\n* Current daily cigarette smoker\n* Able to understand study procedures and provide informed consent\n* For females, non-pregnant and non-lactating\n\nExclusion Criteria:\n\n* Presence of significant uncontrolled medical conditions (e.g. cardiovascular disease, respiratory disorders, cancer) that could affect smoking behaviors or study participation\n* Presence of major uncontrolled psychiatric disorders (e.g. schizophrenia, bipolar disorder, severe depression)\n* Current substance use disorder (except nicotine dependence)\n* Taking medications that could significantly interfere with study objectives (e.g. medications for smoking cessation)\n* Significant cognitive impairment that precludes ability to complete study procedures",{"count":158,"type":23},200,"OBSERVATIONAL","This case-control study aims to investigate the genetic and molecular bases of nicotine addiction to identify potential therapeutic targets. The project will involve drug repurposing using Mendelian Randomization, a smoking cessation intervention, and the analysis of methylation status in participants undergoing nicotine withdrawal.",[162,163,164,165,166,167],"Smoking Cessation","Smoking Cessation Intervention","Nicotine Addiction","Epigenetics","Molecular Biology","Genetic Epidemiology",[164,162,169,170,167,171,172],"Mendelian Randomization","Methylation","Drug Repurposing","Epigenetic Biomarkers","2024-06-23",{"date":175,"type":39},"2024-06-25",{"date":177,"type":39},"2023-11-01",{"date":179,"type":23},"2025-10-31",{"name":45,"class":46},{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":133,"enrollmentInfo":189,"targetDuration":4,"studyType":24,"phases":190,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":123},"100552225","biopsychosocial-predictors-of-nicotine-relapse-100552225","NCT06470321","Biopsychosocial Predictors of Nicotine Relapse","Identifying Biomarkers of Stress-induced Neurophysiological Changes and Emotion Regulation Deficits to Predict Relapse During Nicotine Abstinence","BioNic","Inclusion Criteria:\n\n* Age 18-60 years\n* Smoking at least 10 cigarettes daily for at least 2 years\n* Intention to quit smoking\n* Medication-free\n\nExclusion Criteria:\n\n* Presence of psychiatric or medical treatment\n* Pregnancy\n* Current unstable medical illness\n* Recent (prior 6 months) drug or alcohol use disorder\n* Major Depression\n* Diagnosis of psychotic disorder",{"count":158,"type":23},[26],"This study aims to investigate the associations between emotion regulation ability, stress-induced neural activity changes, and susceptibility to relapse in smokers attempting to quit. Participants will undergo assessments of emotion regulation, neural activity via quantitative electroencephalography (qEEG), and stress responses before and during a 24-hour nicotine abstinence period. They will then participate in a computerized smoking cessation intervention, and their abstinence status will be monitored for 6 months.",[193,162,164,194],"Smoking","Tobacco Smoking Behavior",[196,197,198,199,200,201,202],"Nicotine","Relapse","Vulnerability","Biomarkers","EEG","HRV","Stress Reactivity","2024-06-17",{"date":205,"type":39},"2024-06-24",{"date":207,"type":39},"2022-01-01",{"date":209,"type":23},"2025-05-01",{"name":45,"class":46},{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":24,"phases":221,"briefSummary":222,"conditions":223,"keywords":226,"overallStatus":230,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":4},"100552022","12-week-tele-exercise-program-in-patients-with-osa-100552022","NCT06467682","12-week Tele-exercise Program in Patients With OSA","The Role of a Wearables-track Tele-exercising Program on Cognitive Function and Brain Oxygenation in Patients With Obstructive Sleep Apnea","Inclusion criteria\n\n* age ≥18-to-≤70 years,\n* apnea hypopnea index (AHI) ≥15 events\u002Fh,\n* no contraindications (e.g. unstable angina during the previous month, myocardial infarction during the previous month, resting heart rate \\>120 bpm, systolic blood pressure \\>180 mmHg and diastolic blood pressure \\>100 mmHg) for 6-minute walk test (6MWT)\n* body mass index (BMI) \\\u003C40 kg\u002Fm2\n* without daily physical working strain\n* without active self-reported symptoms (fatigue and dyspnea)\n* without pregnancy for women\n* patients with preexistent musculoskeletal disability will be excluded since their condition might impair maximum exercise capacity\n* all participants should speak and read Greek","69 Years",{"count":220,"type":23},60,[26],"Obstructive sleep apnea (OSA) contributes to a number of adverse health effects, particularly on brain health. Chronic sleep disturbances caused by OSA could adversely affect cognitive health. Exercise is recommended as a non-pharmacological intervention for patients who are intolerant to continuous positive airway pressure (CPAP) and has been shown to have beneficial effects on brain health and cognitive function. The aim of this protocol is to investigate the effects of a 12-week tele-exercise program on cognitive function and specific parameters of brain activity, including brain metabolism and oxygenation, in patients with OSA. The project aims to demonstrate the multi-dimensional relationship between exercise, cognition and brain oxygenation\u002Fmetabolism. Our local ethics committee has approved the study. Our population sample (group A = OSA with cognitive impairment (CI) and tele-exercise; group B = OSA with CI and no tele-exercise; group C = OSA without CI and no tele-exercise) will undergo assessment both before and after a 12-week tele-exercise intervention program. This assessment will include a comprehensive battery of subjective and objective assessment tests. Data will be analysed according to group stratification. We hypothesize a beneficial effect of tele-exercise on sleep and cognitive parameters and we are confident that this study will raise awareness among healthcare professionals of the brain health benefits of exercise in patients with low compliance to CPAP treatment.",[224,225],"Obstructive Sleep Apnea","Cognitive Impairment",[227,228,229],"tele-rehabilitation","tele-exercise","brain health","NOT_YET_RECRUITING","2024-06-14",{"date":233,"type":39},"2024-06-21",{"date":235,"type":23},"2024-09",{"date":237,"type":23},"2025-05",{"name":45,"class":46},""]