[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Eastern Finland\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":164},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,58,93,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":5},"100626005","exercise-and-dietary-lifestyle-intervention-on-reducing-atrial-fibrillation-burden-cardiac-and-body-fat-mass-100626005",false,"NCT07430007","Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.","Effect of a Tailored Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass in Overweight and Obese Patients. The MOVE-AF Ran-domized Clinical Trial","MOVE-AF","Inclusion Criteria:\n\n* Age 18-75 years\n* Body mass index (BMI) ≥27 kg\u002Fm²\n* Documented atrial fibrillation (paroxysmal or persistent)\n* Ability to participate in exercise training and follow study procedures\n* Access to a smartphone or device enabling rhythm monitoring\n* Provides written informed consent\n\nExclusion Criteria:\n\n* Permanent atrial fibrillation\n* Unstable angina pectoris or acute coronary syndrome within the past 3 months\n* Participation in other lifestyle or drug weight reduction trials\n* Significant left ventricular dysfunction (ejection fraction \\\u003C30%)\n* Severe valvular heart disease or planned cardiac surgery\n* Severe heart failure (NYHA class IV) or severe angina (CCS class IV)\n* Unstable coronary artery disease or recent myocardial infarction\n* Severe pulmonary disease limiting exercise capacity\n* Active malignancy\n* Autoimmune or systemic inflammatory diseases\n* Severe renal or hepatic failure\n* Memory disease or significant cognitive impairment\n* Unstable psychiatric condition\n* Recent joint or back surgery within the past 6 months\n* Continuing back or joint pain symptoms and inability to take part in individualized exercise training\n* Contraindications to exercise testing or training, including cardiac symptoms or cardiovascular symptoms, making exercise unsafe\n* Pregnancy or breastfeeding\n* Participation in another interventional study\n* Any condition judged by investigators to make participation unsafe or infeasible",true,"ALL","18 Years","75 Years",{"count":22,"type":23},158,"ESTIMATED","INTERVENTIONAL",[26],"NA","Atrial fibrillation (AF) is the most common cardiac arrhythmia and is strongly associated with obesity and excess body fat. Lifestyle interventions, including exercise and dietary modification, may reduce AF burden, but long-term randomized controlled trial evidence with objective AF burden assessment and advanced cardiac imaging is limited.\n\nThe MOVE-AF trial is a randomized controlled trial designed to evaluate whether a 12-month tailored exercise and dietary lifestyle intervention, compared with usual care, reduces atrial fibrillation burden and symptom severity and decreases cardiac and total body fat mass in overweight and obese adults with paroxysmal or persistent AF.",[29,30],"Atrial Fibrillation (AF)","Obesity & Overweight",[32,33,34,35,36,37,38,39,40,41,42,43,44,45],"Exercise training","Dietary intervention","Lifestyle intervention","Cardiac fatness","Cardiorespiratory fitness","Continuous rhythm monitoring","Photoplethysmography","Body composition analysis","Cardiac MRI","Cost effectiveness","Body composition","Quality of life","AF burden","AF symptoms","RECRUITING","2026-02-23",{"date":49,"type":50},"2026-02-24","ACTUAL",{"date":52,"type":50},"2025-10-30",{"date":54,"type":23},"2028-12-31",{"name":56,"class":57},"University of Eastern Finland","OTHER",{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":66,"minAge":67,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":24,"phases":70,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},"100621357","evolution-of-lesions-in-repeated-biparametric-prostate-magnetic-resonance-imaging-100621357","NCT07369570","Evolution of Lesions in Repeated Biparametric Prostate Magnetic Resonance Imaging","A Prospective Study of the Evolution of Lesions in Repeated Biparametric Prostate Magnetic Resonance Imaging","REMRI","Inclusion Criteria:\n\n* Suspicion of a local prostate cancer\n* Patient have 1-2 PI-RADS 3-5 lesion\u002Flesions in biparametric prostate MRI, with no ISUP 2-5 prostate cancer in an initial systematic or lesion-targeted (at least two biopsy cores per lesion) biopsy\n* Prostate biopsies can be taken via transrectal approach in an outpatient clinic\n* An estimated life expentancy exceeding 10 years\n* The patient is cooperative, fluent in Finnish and understands the significance of the study\n* The patient signs an informed consent form approved by the ethics committee.\n\nExclusion Criteria:\n\n* The patient had undergone prostate biopsies prior to the biopsies that led to recruitment for the current study.\n* The physician's suspicion of a locally advanced or a high risk prostate cancer. Absolute exclusion criteria are PSA \\>20 ng\u002Fml or T4 staged prostate finding MRI or clinical examination\n* Seriuos infectious or non-infectious complication after initial biopsy\n* Deep immunosuppression due to organ transplant, hematologic disease, or related causes.\n* Any treatment given for prostate cancer diagnosed in initial biopsy\n* Hip prosthesis or any other object in the pelvic area that affects high-quality MRI\n* Claustrophobia or other absolute or relative contraindication for high-quality MRI","MALE","40 Years",{"count":69,"type":23},100,[26],"The goal of this clinical trial is to prospectively investigate the evolution of lesions in biparametric magnetic resonance imaging (bpMRI) of the prostate in men with no clinically significant prostate cancer (csPCa) in their initial biopsy. The main questions it aims to answer are:\n\nDoes lesion progression in bpMRI predict a diagnosis of csPCa in per-protocol follow-up biopsies?\n\nWhat are the radiological and clinical risk factors for csPCa in per-protocol follow-up biopsies?",[73],"Prostate Cancer (Diagnosis)",[75,76,77,78,79,80,81,82,83,84,85],"prostate cancer","magnetic resonance imaging","mri","evolution","progression","pi-rads","significant","likert","pirads","biparametric","bpmri","2026-02-22",{"date":49,"type":50},{"date":47,"type":50},{"date":90,"type":23},"2037-12-31",{"name":56,"class":57},1,{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":18,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":92},"100549764","psychiatric-outreach-nurses-supporting-adolescent-mental-health-100549764","NCT06438276","Psychiatric Outreach Nurses Supporting Adolescent Mental Health","Supporting Adolescent Mental Health by Psychiatric Outreach Nurses: A Mixed Method Evaluation Study","JAPSY","Inclusion Criteria:\n\n* Adolescents (12-16 years old) who seek help from student welfare services due to mood disorders and who have one or more of the following conditions: prolonged and\u002For complicated anxiety, mood symptoms, obsessive-compulsive and\u002For eating disorder symptoms, mild to moderate self-harm (e.g. death wishes or cutting). In addition, person's motivation to receive the service provided is an admission criterion.\n\nExclusion Criteria:\n\n* Persons with one or more of the following needs or life situations: adolescents who need light support and guidance, young people with a single problem of low motivation for school, young people with a stressful life situation or relationship problems. On the other hand, adolescents who are in acute need of specialist care or for adolescents with multidisciplinary problems for whom support measures have already been put in place, because of their mental health symptoms (e.g. severe depression, psychotic symptoms, severe and acute suicidal tendencies or a clear suicide plan).\n* Exclusion criteria for the intervention and control groups also include situations where the adolescent has a long-lasting, already established mental health problem and\u002For a need for further treatment after a period of specialised hospital care.\n* Exclusion criteria also include behavioural disorders where there is a clear underlying cause other than a mental disorder.","12 Years","16 Years",{"count":104,"type":23},160,"OBSERVATIONAL","The study evaluates the effectiveness and cost-effectiveness of the outreach work of psychiatric registered nurses (RN) and the experiences of professionals in the field. The service is provided in school environment. First, the study will assess the effectiveness of brief interventions provided by psychiatric outreach nurses on the perceived mental health and quality of life of adolescents (12-16 year old pupils) and their use of social and health services, compared to the support\u002Ftreatment provided by conventional student welfare services at 6 and 12 months follow-up. The intervention is an outreach service provided by psychiatric nurses. In the intervention, the psychiatric registered nurse will implement interventions such as usual care, discussion, psychoeducation, substance abuse skills and various methods (such as interpersonal psychotherapy = IPT-N and Cool Kids) and motivational interviewing.\n\nSecondly, an economic evaluation of the service will be carried out at 6 and 12 months follow-up. The economic evaluation will be carried out from the perspective of the Wellbeing Services County, including the costs of implementing the intervention model and its effects on adolescents' use of student welfare services as well as other social and health services. Primarily, the economic evaluation will use quality-weighted life years as a measure of effectiveness. Also analysis using depression, anxiety and substance use measures will be conducted. Thirdly, the study will explore the experiences of psychiatric nurses implementing the service as well as the experiences of their collaborators in schools (public health nurses, school social workers, psychologists, doctors and teachers) about the service and its implementation.",[108,109],"Depression","Anxiety",[111,112,113,114,115,116,117],"mental health","mental disorders","adolescent","outreach service","school-based","effectiveness","economic evaluation","2024-05-24",{"date":120,"type":50},"2024-05-31",{"date":122,"type":50},"2024-05-06",{"date":124,"type":23},"2026-12-31",{"name":56,"class":57},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":24,"phases":136,"briefSummary":137,"conditions":138,"keywords":144,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":92},"100297781","stop-diabetes---knowledge-based-solutions-100297781","NCT03156478","STOP DIABETES - Knowledge-based Solutions","StopDia","Inclusion Criteria:\n\n* age of 18-70 years\n* 12 points or more in the Finnish diabetes risk score or previous gestational diabetes or repeated impaired fasting glucose (IFG) (fasting plasma glucose level 6,1 - 6,9 mmol\u002Fl) or impaired glucose tolerance (2-hour glucose level 7,8 - 11,0 mmol\u002Fl in oral glucose tolerance test)\n* living in the hospital district of Northern Savo, Päijät-Häme or South Karelia\n* possibility to use computer, smartphone or tablet with internet connection\n* having own self-phone number\n* adequate Finnish language skill\n\nExclusion Criteria:\n\n* type 1 or 2 diabetes\n* pregnancy or breastfeeding\n* current cancer or less than 6 months from the end of cancer treatment","70 Years",{"count":135,"type":23},10000,[26],"The aim of the Stop Diabetes - Knowledge based solutions (StopDia) consortium project (University of Eastern Finland, National Institute for Health and Welfare, and Technical Research Centre of Finland) is to develop and test approaches to identify individuals at increased risk of type 2 diabetes and to empower them in adopting and maintaining a healthy lifestyle by combining individual and environment level strategies into a dual-process approach targeting deliberative and automatic processes of behavior. We also aim to identify barriers and facilitators of adopting a healthy lifestyle in the society, create a model for the prevention of type 2 diabetes by joint actions of health care, third sector, and other societal actors, and develop methods to monitor the cost-effectiveness of these actions. We will carry out a 1-year randomized controlled trial on the effects of among 10 000 individuals aged 18-70 years at increased risk of type 2 diabetes living in Finland. The participants will be randomized into the control group, the digital lifestyle intervention group, or the combined digital and face-to-face lifestyle intervention group. The aim of the interventions is to enhance diet quality, increase physical activity, decrease body weight, and improve glucose tolerance in individuals at increased risk of type 2 diabetes.",[139,140,141,142,143],"Type2 Diabetes","Life Style","Diet Habit","Physical Activity","Empowerment",[145,146,147,148,149,150,151,152,153,154,155],"Prevention","Digital solutions","Type 2 diabetes","Life style modification","Physical activity","Healthy diet","Health economics","Environmental choice architecture","Socio-economic facilitators","Socio-economic barriers","Wellbeing","2017-05-15",{"date":158,"type":50},"2017-05-17",{"date":160,"type":50},"2017-04-10",{"date":162,"type":23},"2037-12",{"name":56,"class":57},""]