[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Electronic Science and Technology of China\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":500},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,45,62,78,94,120,145,167,192,216,241,263,286,314,341,362,381,409,435,457,471,485],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644500","chatbot-intervention-effects-on-emotional-arousal-in-anhedonia-100644500",false,"NCT07671131","Chatbot Intervention Effects on Emotional Arousal in Anhedonia","Effects of a Chatbot-Based Intervention on Subjective Arousal and Neural Reactivity to Emotional Video Stimuli in Individuals With Anhedonia","Inclusion Criteria:\n\n* 18-40 years\n* Right-handed\n* Normal or corrected normal visual acuity\n* Participants must show elevated anhedonia and depressive symptoms at screening, defined as a total score of 23.5 or higher on the Snaith-Hamilton Pleasure Scale and a score of 14 or higher on the Beck Depression Inventory\n\nExclusion Criteria:\n\n* History of major central nervous system disorders, such as epilepsy, traumatic brain injury, stroke, or brain tumors.\n* History of severe mental illness, including schizophrenia spectrum disorders, bipolar disorder, or other psychotic disorders.\n* History of substance or alcohol use disorder or substance or alcohol misuse within the past 12 months that may affect study participation or outcome assessment.\n* Individuals currently at high risk of suicide, severe self-harm, or experiencing an acute psychiatric crisis.\n* Individuals who are currently using psychiatric medications or have undergone psychotherapy within the past 4 weeks that may significantly affect mood, motivation, or reward processing.\n* Severe vision or hearing impairments that cannot be corrected and would interfere with task performance.\n* Contraindications to MRI scanning, including metallic implants, pacemakers, severe claustrophobia, or other conditions incompatible with MRI.\n* Pregnancy or breastfeeding.",true,"ALL","18 Years","40 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on affective arousal in college students with elevated levels of depression and anhedonia by combining a randomized active-control intervention design with pre- and post-intervention emotional video task assessments during fMRI.",[28],"Healthy",[30,31],"AI interaction","fMRI","RECRUITING","2026-06-22",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":22},"2026-06-20",{"date":40,"type":22},"2028-12-31",{"name":42,"class":43},"University of Electronic Science and Technology of China","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":60,"leadSponsor":61,"locationsCount":44},"100644309","chatbot-intervention-effects-on-belief-updating-in-anhedonia-100644309","NCT07663019","Chatbot Intervention Effects on Belief Updating in Anhedonia","Effects of a Chatbot-Based Intervention on Valence-Dependent Belief Updating and Expectancy Bias for Life Events in Individuals With Anhedonia",{"count":21,"type":22},[25],"The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on belief updating in college students with elevated levels of depression and anhedonia by combining a randomized active-control intervention design with pre- and post-intervention behavioral belief updating task assessments.",[28],[31,56],"AI Interaction",{"date":58,"type":36},"2026-06-23",{"date":38,"type":22},{"date":40,"type":22},{"name":42,"class":43},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":68,"targetDuration":4,"studyType":23,"phases":69,"briefSummary":70,"conditions":71,"keywords":72,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":76,"leadSponsor":77,"locationsCount":44},"100644237","chatbot-intervention-effects-on-social-and-monetary-incentive-processing-in-anhedonia-100644237","NCT07665242","Chatbot Intervention Effects on Social and Monetary Incentive Processing in Anhedonia","Effects of a Chatbot-Based Intervention on Behavioral Responsiveness and Neural Anticipation of Social and Monetary Incentives in Individuals With Anhedonia",{"count":21,"type":22},[25],"The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on social incentive processing in college students with elevated levels of depression and anhedonia by combining a randomized active-control intervention design with pre- and post-intervention Social Incentive Delay Task assessments during fMRI.",[28],[31,56],{"date":74,"type":36},"2026-06-24",{"date":38,"type":22},{"date":40,"type":22},{"name":42,"class":43},{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":90,"startDateStruct":91,"completionDateStruct":92,"leadSponsor":93,"locationsCount":44},"100644190","chatbot-intervention-effects-on-resting-state-brain-function-in-anhedonia-100644190","NCT07665216","Chatbot Intervention Effects on Resting-State Brain Function in Anhedonia","Effects of a Chatbot-Based Intervention on Resting-State Functional Connectivity and Spontaneous Neural Activity in Individuals With Anhedonia",{"count":21,"type":22},[25],"The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on resting-state brain function in college students with elevated anhedonia and depressive symptoms. The study will use a randomized active-control intervention design with pre- and post-intervention resting-state functional magnetic resonance imaging assessments.",[28],[89,31,30],"reward processing",{"date":74,"type":36},{"date":38,"type":22},{"date":40,"type":22},{"name":42,"class":43},{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":16,"sex":101,"minAge":18,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":23,"phases":104,"briefSummary":105,"conditions":106,"keywords":107,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":44},"100635974","oxytocins-effects-on-real-time-fmri-neurofeedback-training-of-anterior-insula-activity-100635974","NCT07559656","Oxytocin's Effects on Real Time-fMRI Neurofeedback Training of Anterior Insula Activity","Effects of Intransal Oxytocin on Real-time fMRI Neurofeedback Training of Anterior Insula Activity Using an Interoceptive Strategy","Inclusion Criteria:\n\n* Healthy subjects without any past or present psychiatric or neurological disorders.\n\nExclusion Criteria:\n\n* History of brain injury medical or mental illness.\n* Contraindication to MRI scanning (e.g., metal implants, claustrophobia or other --conditions that make them inappropriate for MRI scanning).","MALE","30 Years",{"count":21,"type":22},[25],"The primary aim of this study is to investigate whether intranasal oxytocin can modulate the real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback training effects by facilitating the use of an interoceptive strategy.",[28],[108,109,110,111],"Oxytocin","Real-time neurofeedback","Anterior insula","Interoceptive strategy","2026-04-23",{"date":114,"type":36},"2026-04-30",{"date":116,"type":22},"2026-04-26",{"date":118,"type":22},"2026-10-01",{"name":42,"class":43},{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":16,"sex":101,"minAge":18,"maxAge":102,"enrollmentInfo":127,"targetDuration":4,"studyType":23,"phases":129,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":44},"100625692","oxytocins-effects-on-emotional-processing-and-its-acting-routes-100625692","NCT07425938","Oxytocin's Effects on Emotional Processing and Its Acting Routes","The Modulatory Effects of Oxytocin on Emotional Processing and Its Acting Routes","Inclusion Criteria:\n\n* Healthy subjects without past or current psychiatric or neurological disorders\n\nExclusion Criteria:\n\n* History of head injury.\n* Medical or psychiatric illness.\n* Subjects take a certain drug for a long period of time.\n* Subjects have metal implants in their bodies.",{"count":128,"type":22},120,[25],"The main goal of this study is to investigate the modulatory effects of intranasally administrated oxytocin on the processing of emotional stimuli and its acting routes.",[132],"Healthy Adult Male",[134,135,136],"oxytocin","negative emotion","vasoconstrictor","2026-02-20",{"date":139,"type":36},"2026-02-23",{"date":141,"type":36},"2026-01-24",{"date":143,"type":22},"2026-04-15",{"name":42,"class":43},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":102,"enrollmentInfo":152,"targetDuration":4,"studyType":23,"phases":154,"briefSummary":155,"conditions":156,"keywords":157,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":164,"leadSponsor":166,"locationsCount":44},"100622889","continuous-vs-intermittent-rt-fmri-neurofeedback-training-of-the-anterior-insula-100622889","NCT07389486","Continuous vs. Intermittent Rt-fMRI Neurofeedback Training of the Anterior Insula","A Comparative Study of Continuous vs. Intermittent Real-time fMRI Neurofeedback in Regulating Anterior Insula Activity","Inclusion Criteria:\n\nHealthy subjects without any past or present psychiatric or neurological disorders\n\nExclusion Criteria:\n\nHistory of brain injury medical or mental illness\n\nContraindication to MRI scanning (e.g., metal implants, claustrophobia or other --conditions that make them inappropriate for MRI scanning)",{"count":153,"type":22},90,[25],"The main aim of this study is to compare the efficacy of intermittent with continuous real-time functional magnetic resonance imaging (fMRI) neurofeedback on anterior insula regulation and associated behavioral changes.",[28],[109,110,158,159],"Feedback types","Interoceptive processing","2026-01-28",{"date":162,"type":36},"2026-02-05",{"date":160,"type":36},{"date":165,"type":22},"2027-06-08",{"name":42,"class":43},{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":177,"briefSummary":178,"conditions":179,"keywords":181,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":44},"100620935","real-time-neurofeedback-training-of-the-medial-prefrontal-cortex-based-on-imagined-social-support-100620935","NCT07364084","Real-time Neurofeedback Training of the Medial Prefrontal Cortex Based on Imagined Social Support","Self-modulation of the mPFC Using Rt-fMRI NF Training to Improve Negative Anticipation for Future Events","Inclusion Criteria:\n\n* -Healthy subjects without any past or present psychiatric or neurological disorders\n\nExclusion Criteria:\n\n* History of brain injury\n* Psychiatric or Neurological Disorder\n* Contraindications for MRI\n* Regular use of psychotropic substances (medication, drugs)","35 Years",{"count":176,"type":22},60,[25],"Randomized active-sham controlled between-subject real-time fMRI neurofeedback trial aiming to modulate activity in the medial prefrontal cortex (mPFC) to improve subjective negative anticipation.",[28,180],"Neurofeedback",[182,183,184],"real-time neurofeedback","social support","mPFC","2026-01-26",{"date":160,"type":36},{"date":188,"type":36},"2026-01-16",{"date":190,"type":22},"2026-07-30",{"name":42,"class":43},{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":102,"enrollmentInfo":199,"targetDuration":4,"studyType":23,"phases":200,"briefSummary":201,"conditions":202,"keywords":204,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":215},"100621211","the-power-of-belief-expectation-driven-and-placebo-modulation-of-empathic-pain-100621211","NCT07367672","The Power of Belief: Expectation-driven and Placebo Modulation of Empathic Pain","PoB-EP","Inclusion Criteria:\n\n* (1) Healthy subjects without any past or present psychiatric or neurological disorders; (2) Healthy subjects without any current psychotherapeutic medication.\n\nExclusion Criteria:\n\n* (1) Participant with any past or present psychiatric or neurological disorders; (2)Participant with any current psychotherapeutic medication.",{"count":128,"type":22},[25],"This study investigates how belief and expectation influence empathic pain-the pain we feel when observing others in distress. Healthy adult participants will be randomly assigned to one of three groups: no-treatment control, placebo nasal spray, oxytocin-containing nasal spray. Participants in both the placebo and oxytocin conditions will be informed that they are receiving oxytocin, described as a potent agent for pain relief. During functional MRI scanning, all participants will view naturalistic pain-related videos and provide ratings of perceived subjective pain. The study aims to examine how cognitive beliefs and neuromodulatory interventions alter subjective pain experience and brain activity, including changes in brain network communication.",[203],"Healthy Participants",[205,206,31,108,207],"Analgesic expectation","Empathic pain","Placebo","2026-01-18",{"date":185,"type":36},{"date":211,"type":36},"2025-12-01",{"date":213,"type":22},"2026-03-30",{"name":42,"class":43},2,{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":102,"enrollmentInfo":223,"targetDuration":4,"studyType":23,"phases":225,"briefSummary":226,"conditions":227,"keywords":229,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":44},"100621383","the-effects-of-transcutaneous-auricular-vagus-nerve-stimulation-tavns-on-anxiety-responses-and-emotional-regulation-100621383","NCT07369908","The Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Anxiety Responses and Emotional Regulation","The Modulatory Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Anxiety Responses and Emotional Regulation","Inclusion Criteria:\n\n* Healthy subjects without past or current psychiatric or neurological disorders.\n\nExclusion Criteria:\n\n* History of head injury.\n* Medical or psychiatric illness.\n* Subjects take a certain drug for a long period of time.\n* Subjects have metal implants in their bodies.",{"count":224,"type":22},140,[25],"The main aim of this study is to investigate whether transcutaneous auricular vagus nerve stimulation (taVNS) can reduce anxiety and have an effect on emotional regulations",[228],"Healthy Male and Female Volunteers",[230,231,232,233],"taVNS","anxiety","emotional regulation","high-trait anxiety",{"date":235,"type":36},"2026-01-27",{"date":237,"type":36},"2025-10-09",{"date":239,"type":22},"2026-04-16",{"name":42,"class":43},{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":174,"enrollmentInfo":248,"targetDuration":4,"studyType":23,"phases":249,"briefSummary":250,"conditions":251,"keywords":252,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":262,"locationsCount":44},"100605443","oxytocin-and-human-defensive-responses-in-a-dynamic-situation-100605443","NCT07162584","Oxytocin and Human Defensive Responses in a Dynamic Situation","The Modulatory Affect of Oxytocin on Human Defensive Responses During Dynamic Predator-prey Interactions","Inclusion Criteria:\n\n* Healthy subjects without past or current psychiatric or neurological disorders\n\nExclusion Criteria:\n\n* History of head injury; pregnant, menstruating, taking oral contraceptives; medical or psychiatric illness,\n* The presence of metal in the body or claustrophobia.",{"count":21,"type":22},[25],"The presnet study is to investigate the effect of intranasal oxytocin (24 IU) treatment on modulating how human responsd to threat in a dynamic situation.",[28],[134,31,253,254,255],"escape decisions","dynamic predator-prey interaction","defensive responses","2025-09-30",{"date":258,"type":36},"2025-10-06",{"date":260,"type":36},"2025-09-13",{"date":160,"type":22},{"name":42,"class":43},{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":174,"enrollmentInfo":269,"targetDuration":4,"studyType":23,"phases":271,"briefSummary":272,"conditions":273,"keywords":274,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":44},"100609185","individual-differences-in-cognitive-control-predict-real-time-fmri-neurofeedback-performance-100609185","NCT07211269","Individual Differences in Cognitive Control Predict Real-time fMRI Neurofeedback Performance","Inclusion Criteria:\n\n* Healthy subjects without any past or present psychiatric or neurological disorders\n\nExclusion Criteria:\n\n* History of brain injury Medical or mental illness and color blindness or weakness.\n* The presence of metal in the body or claustrophobia.",{"count":270,"type":22},40,[25],"The goal of this study is to investgate whether individual differences of cognitive control capacity could predict neurofeedback performance and the behavioral effects resulting from successful anterior insula regulation via interoceptive strategy.",[28],[275,276,277],"Neurofeedback Performance","Interoception","Cognitive Control","2025-09-29",{"date":280,"type":36},"2025-10-07",{"date":282,"type":36},"2025-09-03",{"date":284,"type":22},"2026-01-12",{"name":42,"class":43},{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":16,"sex":101,"minAge":18,"maxAge":174,"enrollmentInfo":294,"targetDuration":4,"studyType":23,"phases":296,"briefSummary":298,"conditions":299,"keywords":300,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":44},"100603724","early-phase-1-the-effect-of-oral-oxytocin-and-atosiban-on-top-down-attention--otatosiban--100603724","NCT07140237","The Effect of Oral Oxytocin and Atosiban on Top-down Attention ( OTAtosiban )","The Influence and Regulatory Role of Exogenous and Endogenous Oxytocin on Top-down Attention in Humans","OTAtosiban","Inclusion Criteria:\n\n* Healthy male subjects without past or current psychiatric or neurological disorders\n\nExclusion Criteria:\n\n* History of or current neurological\u002Fpsychiatric disorders;\n* Use of psychotropic medications (including nicotine)\n* Visual impairments",{"count":295,"type":22},250,[297],"EARLY_PHASE1","The main aim of the present study is to investigate whether orally (lingual spray) administered oxytocin influences human top-down attention via oxytocin receptors and whether its effects are dose- and task-dependent.",[132],[301,108,302,303,304,305],"Oxytocin; Atosiban; Eye-tracking; Autistic trait","Atosiban","Eye-tracking","Autistic trait","attention","2025-09-05",{"date":308,"type":36},"2025-09-08",{"date":310,"type":22},"2025-09",{"date":312,"type":22},"2025-12-30",{"name":42,"class":43},{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":321,"enrollmentInfo":322,"targetDuration":4,"studyType":23,"phases":323,"briefSummary":324,"conditions":325,"keywords":329,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":44},"100601490","neuromodulation-and-attention-deficits-in-mdd-100601490","NCT07111169","Neuromodulation and Attention Deficits in MDD","Selective Attention Deficits and Neuromodulation in Major Depressive Disorder: Using EEG and MRI-guided iTBS Study","Inclusion Criteria:\n\n* 18-55 years\n* Right-handed\n* Normal or corrected normal visual acuity\n* MDD: meet the proposed DSM-5 MDD criteria, unmedicated or stable medicated within the last one month. Healthy subjects without any past or present psychiatric or neurological disorders.\n\nExclusion Criteria:\n\n* Diagnosis of other severe mental disorders, such as schizophrenia, bipolar disorder, neurodevelopmental disorder, etc.\n* high suicidal risk\n* Unnormal intellectual functioning, auditory impairments,\n* Have received neuromodulation, such as Modified Electroconvulsive Therapy (MECT), or any psychotherapy within the past 6 months.\n* Only for the active-iTBS group: have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning).","55 Years",{"count":176,"type":22},[25],"Multimodal study (Behavior, TMS, EEG) combining a sham-controlled intermittent theta burst stimulation (iTBS) intervention with an additional-singleton task and EEG to evaluate whether left dorsolateral prefrontal cortex (DLPFC) stimulation enhances cognitive control and modulates maladaptive attention processes in MDD and whether the effects are influenced by neuronavigated versus manual (Beam F3 method) localization of the stimulation site.",[326,327,328],"Major Depression Disorder","Cognitive Deficits","Selective Attention",[330,331,332],"iTBS","EEG","MDD","2025-07-31",{"date":335,"type":36},"2025-08-08",{"date":337,"type":36},"2024-01-01",{"date":339,"type":22},"2028-12-30",{"name":42,"class":43},{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":16,"sex":101,"minAge":18,"maxAge":174,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":348,"briefSummary":349,"conditions":350,"keywords":352,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":44},"100600097","early-phase-1-the-effect-of-oral-oxytocin-and-atosiban-on-social-attention-100600097","NCT07093060","The Effect of Oral Oxytocin and Atosiban on Social Attention","The Influence and Regulatory Role of Exogenous and Endogenous Oxytocin on Social Attention in Humans",{"count":295,"type":22},[297],"The main aim of the present study is to investigate whether orally (lingual spray) administered oxytocin influences human social attention and behaviors via oxytocin receptors and whether its effects are dose- and task-dependent.",[351],"Healhty",[108,302,353,304],"Eye tracking","2025-07-28",{"date":356,"type":36},"2025-07-30",{"date":358,"type":36},"2025-06-09",{"date":360,"type":22},"2025-11-30",{"name":42,"class":43},{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":102,"enrollmentInfo":368,"targetDuration":4,"studyType":23,"phases":370,"briefSummary":372,"conditions":373,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":380,"locationsCount":44},"100591030","phase-1-tavns-effects-on-fear-ratings-in-naturalistic-context-100591030","NCT06975124","taVNS Effects on Fear Ratings in Naturalistic Context","Inclusion Criteria:\n\nHealthy participants without color blindness, current or regular substance or medication use, any current or history of medical or psychiatric disorders and contraindications for MRI.\n\nExclusion Criteria:\n\n* Color blindness,\n* Current or regular substance or medication use\n* any current or history of medical or psychiatric disorders and contraindications for MRI",{"count":369,"type":22},70,[371],"PHASE1","During the fear rating task, 70 participants viewed a 600-second horror movie while continuously rating their subjective fear intensity (0-100 scale) every 0.51 seconds (1,170 total ratings). Functional near-infrared spectroscopy (fNIRS) data were simultaneously recorded using the NIRSIT LITE system to monitor cortical hemodynamic responses.",[203],"2025-05-07",{"date":376,"type":36},"2025-05-16",{"date":378,"type":36},"2025-03-01",{"date":333,"type":22},{"name":42,"class":43},{"id":382,"slug":383,"hasResults":11,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":387,"eligibilityCriteria":388,"healthyVolunteers":11,"sex":389,"minAge":18,"maxAge":390,"enrollmentInfo":391,"targetDuration":4,"studyType":23,"phases":393,"briefSummary":394,"conditions":395,"keywords":397,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":44},"100586208","pain-relief-from-dysmenorrhea-employing-tavns-100586208","NCT06912386","Pain Relief From Dysmenorrhea Employing taVNS","A Randomized Two-Way Crossover Comparison Study of Pain Relief From Dysmenorrhea Employing taVNS and Sham Stimulation","taVNS-DYSM","Inclusion Criteria:\n\n* Regular menstrual cycle (28 days ± 7 days);\n* Average moderate menstrual pain (with 4 - 7 NRS scores);\n* History of over-the-counter (OTC) analgesic use for the treatment of menstrual pain (at least 1 IBUPROFEN for the first two days);\n* 4 consecutive monthly menstrual cycles;\n* Non-pregnant status;\n* Agrees to use adequate birth control during the trial;\n* Otherwise, healthy;\n* Agree not to participate in any other clinical trial while enrolled in this trial ;\n* No facial or ear pain, no recent ear trauma, no metal implants including pacemakers;\n* Normal ECG, Heart Rate and Blood Pressure (systolic BP 105-130, diastolic BP 60-90, heart rate per min at rest 60-85);\n\nExclusion Criteria:\n\n* Currently under medications (except for analgesic medication for menstrual cycle);\n* Use of oral contraceptive;\n* Secondary cause for dysmenorrhea (i.e., endometriosis, adenomyosis, uterine fibroids, or infection);\n* Unstable or serious illness (e.g., kidney, liver, GIT, heart conditions, diabetes, thyroid gland function, lung conditions, chronic asthma, diagnosed psychological or mood disorder, hypertension, any bleeding disorders, recent surgery, or concurrent blood thinning treatment);\n* Current malignancy or treatment for malignancy within the previous 2 years;\n* Pregnant or lactating women;\n* Active smokers, nicotine use, or drug (prescription or illegal substances) abuse;\n* Chronic past and\u002For current alcohol use (\\>14 alcoholic drinks per week);\n* Any condition that in the opinion of the investigator, makes the participant unsuitable for inclusion;\n* Unwilling or unable to comply with protocol;\n* Active genitourinary infection in the last four weeks;\n* Unable to read or comprehend the informed consent;\n* Unwilling to complete study procedures;\n* Participated in any other clinical trial during the past 1 month;\n* Personal or family history of seizure, mood, or cardiovascular disorders;\n* Allergic reaction to surface electrodes.","FEMALE","45 Years",{"count":392,"type":22},20,[25],"The goal of this clinical trial is to determine if transauricular vagal nerve stimulation (taVNS) is effective in treating moderate dysmenorrhea. The main question it aims to answer is:\n\n• Does taVNS reduce the number of times participants suffering from dysmenorrhea need to use rescue medication during menstruation? Researchers will compare taVNS stimulation with a sham stimulation (a look-alike procedure that does not stimulate the vagus nerve) to assess whether taVNS is effective in treating moderate dysmenorrhea.\n\nParticipants will:\n\n* Undergo taVNS for 2 months and sham stimulation for another 2 months, each for 5 days per month, starting 2 days before the expected beginning of their menstrual cycle.\n* Visit the clinic twice a month for checkups and tests.\n* Keep a diary to record their pain levels and the number of times they use rescue medication.\n* Undergo functional magnetic resonance imagine two times (one after the end of the first use of taVNS and another after the end of the first use of SHAM stimulation).",[396],"Dysmenorrhea Primary",[398,399,400],"Dysmenorrhea","transauricular vagal nerve stimulation","Pain","2025-03-30",{"date":403,"type":36},"2025-04-04",{"date":405,"type":22},"2025-04-01",{"date":407,"type":22},"2025-06-30",{"name":42,"class":43},{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":102,"enrollmentInfo":416,"targetDuration":4,"studyType":23,"phases":418,"briefSummary":419,"conditions":420,"keywords":423,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":44},"100582647","enhancing-emotion-regulation-through-functional-near-infrared-spectroscopy-fnirs-informed-real-time-neurofeedback-100582647","NCT06866028","Enhancing Emotion Regulation Through Functional Near-infrared Spectroscopy (fNIRS)-Informed Real-time Neurofeedback","Enhancing Emotion Regulation Through fNIRS-informed Real-time Neurofeedback","Inclusion Criteria:\n\n* Normal\u002Fcorrected-to-normal vision\n* Right-handed\n* Below the cut-off for clinically-significant levels of depression (below 29) indicated by the Beck Depression Inventory (BDI-II; Beck et al., 1996)\n\nExclusion Criteria:\n\n* Current\u002Fhistory of mental health conditions\n* Current\u002Fhistory of chronic pain\n* The following conditions: Cardiovascular disorder, Raynaud's phenomenon, fainting, seizure, wounds on the hand\u002Farm\n* Frequent use of alcohol\u002Fnicotine",{"count":417,"type":22},50,[25],"The present study aims to employ real-time functional near-infrared spectroscopy (fNIRS) neurofeedback training in combination with cognitive reappraisal strategies for regulating negative emotions in healthy individuals.\n\nParticipants will complete:\n\n* Cognitive reappraisal training with either real neurofeedback or sham feedback.\n* Questionnaires at pre- and post- training timepoints\n* A cold-pressor test at the end of the training\n\nIt is hypothesized that combining real-time fNIRS neurofeedback and cognitive reappraisal training will enhance emotion regulation in healthy individuals:\n\n1. Increased neural activity in the prefrontal cortex (PFC) region of the brain will be significantly higher in the real neurofeedback group after training compared to the sham feedback group.\n2. Real-time fNIRS-guided upregulation of the PFC will enhance emotion regulation during exposure to negative stimuli\u002Fscenes across the training runs.\n3. The effects of fNIRS neurofeedback training will extend to influence emotion regulation in a cold-pressor test administered post-training, wherein individuals in the real neurofeedback group demonstrate better regulation of stress and pain induced by the task.",[180,421,422],"Emotion Regulation","Stress",[424,425,426],"fNIRS","emotion","neurofeedback","2025-03-24",{"date":429,"type":36},"2025-03-27",{"date":431,"type":36},"2024-08-08",{"date":433,"type":22},"2026-08-07",{"name":42,"class":43},{"id":436,"slug":437,"hasResults":11,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":16,"sex":17,"minAge":442,"maxAge":18,"enrollmentInfo":443,"targetDuration":4,"studyType":444,"phases":4,"briefSummary":445,"conditions":446,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":44},"100514682","social-feedback-and-dysfunctional-risk-taking-in-nssi-adolescents-100514682","NCT05981677","Social Feedback and Dysfunctional Risk Taking in NSSI Adolescents","Risk and Social Feedback in Adolescents With Nonsuicidal Self-Injury","Inclusion Criteria:\n\n* 15-18 years\n* right-handed\n* normal or corrected normal visual acuity\n* meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)\n\nExclusion Criteria:\n\n* diagnosis of borderline personality disorder, major depressive disorder, other\n* psychiatric disorders, etc.\n* high suicidal risk\n* recent use of medications that can affect neural activity\n* have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months\n* have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)","15 Years",{"count":21,"type":22},"OBSERVATIONAL","Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Problematic interpersonal relationships and decision-making have been demonstrated to play crucial roles in this maladaptive behavior, especially for adolescents. Accumulating evidence suggests that decision processes and risk-taking are strongly influenced by the affective state of the individual. However, whether these interactions are disrupted in NSSI adolescents has not been systematically examined. In the current study, the investigators modified one of the most widely used paradigms for measuring an individual's risk decision-making, the Balloon Analogue Risk Task (BART). The investigators combine social reward (green balloon), punishment (red balloon), and control feedback (yellow balloon), to investigate whether the NSSI adolescents have dysfunctional risk-taking behavior while facing different social outcomes. The investigators recruit one group of NSSI adolescents (n = 40) and one health control (HC) group (n = 40), to compare their risk-related decisions during the emotional BART. The investigators hypothesize that compared to HC, NSSI adolescents will show altered effects of social reward and punishment on risk-related decision-making, in particular higher risk avoidance in the context of social punishment.",[447,448],"Nonsuicidal Self Injury","Risk-Taking","2024-04-09",{"date":451,"type":36},"2024-04-11",{"date":453,"type":36},"2023-12-06",{"date":455,"type":22},"2027-07",{"name":42,"class":43},{"id":458,"slug":459,"hasResults":11,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":11,"sex":17,"minAge":442,"maxAge":18,"enrollmentInfo":463,"targetDuration":4,"studyType":444,"phases":4,"briefSummary":464,"conditions":465,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":467,"startDateStruct":468,"completionDateStruct":469,"leadSponsor":470,"locationsCount":44},"100514677","impact-of-emotional-reactivity-on-dysfunctional-decision-making-in-nssi-adolescents-100514677","NCT05981612","Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents","Effects of Emotional Reactivity on Decision-Making in Adolescents With Nonsuicidal Self-Injury",{"count":21,"type":22},"Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.",[447,466],"Prediction Errors",{"date":451,"type":36},{"date":453,"type":36},{"date":455,"type":22},{"name":42,"class":43},{"id":472,"slug":473,"hasResults":11,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":16,"sex":17,"minAge":442,"maxAge":18,"enrollmentInfo":477,"targetDuration":4,"studyType":444,"phases":4,"briefSummary":478,"conditions":479,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":481,"startDateStruct":482,"completionDateStruct":483,"leadSponsor":484,"locationsCount":44},"100513656","altered-neural-pain-empathic-reactivity-in-nssi-adolescents-100513656","NCT05968313","Altered Neural Pain Empathic Reactivity in NSSI Adolescents","Abnormal Neural Pain Empathic Processing in Adolescents With Non-suicidal Self-Injury",{"count":21,"type":22},"Nonsuicidal self-injury (NSSI) is defined as direct, deliberate bodily harm without suicidal intention. In recent years, growing evidence suggests that NSSI has become a worldwide public health issue. People with NSSI behaviors, especially adolescents, commonly exhibit emotion-related and interpersonal problems. Pain empathy represents an essential basal domain of socio-emotional processing and refers to the ability to empathize, connect and share with others' pain. However, altered empathic processing has not been systematically examined in adolescents with NSSI. To this end, the current functional magnetic resonance imaging (fMRI) study will recruit one group of NSSI adolescents (n=40) and one healthy control (HC) group (n=40), to compare their neural activity regarding pain empathy processing, which is measured by blood oxygenation level-dependent (BOLD) fMRI. The investigators included conditions of physical pain empathy (stimuli depicting noxious stimulation to the limbs) and affective pain empathy (stimuli depicting faces expressing pain) as well as corresponding control stimuli. The investigators hypothesize that compared to HC, NSSI adolescents show increased empathic reactivity to physical pain stimuli in salience and arousal related brain regions but decreased empathic reactivity to affective pain empathic stimuli.",[447,480],"Pain Empathy",{"date":451,"type":36},{"date":453,"type":36},{"date":455,"type":22},{"name":42,"class":43},{"id":486,"slug":487,"hasResults":11,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":16,"sex":17,"minAge":442,"maxAge":18,"enrollmentInfo":492,"targetDuration":4,"studyType":444,"phases":4,"briefSummary":493,"conditions":494,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":495,"startDateStruct":496,"completionDateStruct":497,"leadSponsor":499,"locationsCount":44},"100508976","emotion-regulation-dysfunctions-in-nssi-adolescents-in-naturalistic-contexts-100508976","NCT05907421","Emotion Regulation Dysfunctions in NSSI Adolescents in Naturalistic Contexts","Altered Neural Activation Patterns During Emotion Regulation in Adolescents With Nonsuicidal Self-Injury Under Naturalistic Immersive Emotional Engagement","Inclusion Criteria:\n\n* 15-18 years\n* right-handed\n* normal or corrected normal visual acuity\n* meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)\n\nExclusion Criteria:\n\n* diagnosis of borderline personality disorder, major depressive disorder, other psychiatric disorders, etc.\n* high suicidal risk\n* recent use of medications that can affect neural activity\n* have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months\n* have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)",{"count":21,"type":22},"Nonsuicidal self-injury (NSSI) is defined as direct, deliberate bodily harm without suicidal intention. Recent studies indicate that prevalence rates are increasing worldwide, in particular under adolescents, indicating a growing public health issue. An impaired ability to regulate negative emotion has been suggested to play a potential role in NSSI behavior. Some recent interventions aim at improving dysfunctional emotion regulation via 'acceptance'. Acceptance represents an objective, nonreactive, nonjudgmental, and calming emotion regulation strategy, partly based on the philosophy of dialectical behavior therapy (DBT) that has been widely used in the clinical treatment of NSSI behaviors. The aim of the present functional magnetic resonance imaging (fMRI) study is to examine whether adolescents with NSSI can implement the acceptance strategy in naturalistic emotional contexts (immersive video clips) and whether they differ from healthy controls in terms of behavioral and neural effects. To this end, the investigators recruit one group of NSSI adolescents (n=40) and one healthy control group (n=40), to compare the subjective emotional experience as well as underlying neural activity as measured by blood oxygenation level-dependent (BOLD) fMRI. The investigators hypothesize that compared to HC, NSSI adolescents will experience stronger negative emotions and show dysregulated neural recruitment of brain systems engaged in emotional reactivity and regulations (e.g. limbic regions, default mode network, and frontal regions).",[447,421],{"date":451,"type":36},{"date":453,"type":36},{"date":498,"type":22},"2027-06",{"name":42,"class":43},""]