[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Foggia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":73},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100632440","estim-ul-fes-for-upper-limb-recovery-after-stroke-100632440",false,"NCT07513714","ESTIM-UL: FES for Upper Limb Recovery After Stroke","Efficacy of Functional Electrical Stimulation (FES) Combined With Task- Oriented Training on Upper Limb Recovery in Post-Stroke Patients With Spastic Hemiparesis: A Randomized Controlled Trial","ESTIM-UL","Inclusion Criteria:\n\n* Age 18 years or older.\n* Diagnosis of ischemic or hemorrhagic stroke, documented by CT or MRI.\n* Clinical presence of focal upper limb spasticity, defined as a score ≥ 1+ on the Modified Ashworth Scale (MAS) in at least one target muscle group (elbow, wrist, or finger flexors), treated with Botulinum Toxin Type A injection.\n* Presence of residual voluntary muscle activation (minimal active movement) sufficient to initiate the motor task required by the training (Box and Block score \\> 1).\n* Preserved cognitive function, defined as a Mini-Mental State Examination (MMSE) score ≥ 24 or clinical judgment confirming adequate comprehension and cooperation.\n\nExclusion Criteria:\n\n* Absolute contraindications to Functional Electrical Stimulation (FES), including the presence of a cardiac pacemaker or implantable cardioverter defibrillator (ICD), pharmacologically uncontrolled epilepsy, or skin lesions\u002Fdermatitis at the electrode application sites.\n* Presence of severe muscle-tendon contractures or fixed joint deformities (ankylosis) that mechanically limit passive movement and make active functional recovery unlikely.\n* Severe cognitive impairment, global aphasia, or severe unilateral spatial neglect that prevents task comprehension or active participation in the training program.\n* Concomitant orthopedic or rheumatologic conditions affecting the upper limb (e.g., recent fractures, severe arthritis) that could interfere with treatment delivery or outcome assessment.","ALL","18 Years","80 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Stroke is a leading cause of long-term disability, frequently resulting in impaired upper limb motor function and spasticity. Although Botulinum Toxin Type A (BoNT-A) is effective in reducing focal spasticity, functional recovery of the upper limb often remains limited without intensive, task-specific rehabilitation. Functional Electrical Stimulation (FES), when synchronized with voluntary movement during Task-Oriented Training, may enhance motor recovery by facilitating muscle activation and neuroplasticity. This randomized controlled trial aims to evaluate whether FES combined with Task-Oriented Training is superior to conventional Task-Oriented Training alone in improving upper limb function in post-stroke patients treated with BoNT-A.",[28,29,30],"Stroke","Post-Stroke Spasticity","Post-Stroke Hemiparesis",[32,33,34,35,36],"functional electrical stimulation","Botulinum Toxin Type A","stroke","motor recovery","upper limb","NOT_YET_RECRUITING","2026-03-30",{"date":40,"type":41},"2026-04-07","ACTUAL",{"date":43,"type":22},"2026-05-01",{"date":45,"type":22},"2026-12-01",{"name":47,"class":48},"University of Foggia","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":72,"locationsCount":49},"100632443","focal-vibration-therapy-in-post-stroke-shoulder-pain-100632443","NCT07513753","Focal Vibration Therapy in Post-stroke Shoulder Pain","Efficacy of Focal Vibrational Therapy in Reducing Post-stroke Shoulder Pain: a Double-blind, Randomized Controlled Trial","VIBRA-HSP","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Ischemic or hemorrhagic stroke confirmed by CT or MRI\n* Chronic post-stroke phase (≥ 6 months from event)\n* Presence of hemiplegic shoulder pain (NRS ≥ 4)\n* Preserved cognitive function sufficient to provide informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment or language deficits (e.g., severe aphasia) that prevent understanding of study procedures or reliable reporting of pain (e.g., inability to complete NRS or questionnaires).\n* Severe neglect, apraxia, or disorders of consciousness that interfere with participation in rehabilitation or outcome assessments.\n* Pre-existing shoulder pathology of the affected side unrelated to stroke (e.g., full-thickness rotator cuff tear, advanced glenohumeral osteoarthritis, inflammatory arthritis, prior shoulder surgery).\n* Fixed shoulder contractures or severe joint deformities limiting passive range of motion and preventing standardized assessment.\n* Botulinum toxin injections to shoulder upper limb muscles within the last 3-4 months prior to enrollment .\n* Current treatment with other experimental or non-conventional physical therapies for shoulder pain during the study period.",{"count":59,"type":22},60,[25],"Hemiplegic Shoulder Pain (HSP) is a common and disabling complication after stroke, negatively affecting upper limb function, participation in rehabilitation, and quality of life. Despite the widespread use of conservative and physical therapies, evidence supporting the efficacy of specific non-invasive neuromodulation techniques remains limited.\n\nFocal Vibration Therapy (FVT) is a non-invasive physical modality that delivers localized mechanical vibration to targeted muscles or tendons and may modulate pain, muscle tone, and proprioception through frequency-dependent mechanisms.\n\nThis randomized controlled trial aims to evaluate the efficacy of a multimodal FVT protocol, in addition to standard rehabilitation, compared with a sham intervention plus standard rehabilitation, in reducing pain in patients with chronic post-stroke Hemiplegic Shoulder Pain.",[28,63,64],"Hemiplegic Shoulder Pain","Chronic Stroke Survivors",[66,34,67,63],"Focal vibration Therapy","pain",{"date":40,"type":41},{"date":70,"type":22},"2026-04-01",{"date":45,"type":22},{"name":47,"class":48},""]