[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Freiburg\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":148},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,71,99,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100643463","analysis-of-biomarkers-in-patients-with-acute-myeloid-leukemia-after-allogeneic-stem-cell-transplantation-treated-with-menin-inhibition-100643463",false,"NCT07627568","Analysis of Biomarkers in Patients With Acute Myeloid Leukemia After Allogeneic Stem Cell Transplantation Treated With Menin Inhibition.","AML_MenALLO","Inclusion Criteria:\n\n* Diagnosis of acute myeloid leukemia with NPM1 mutations or KMT2A rearrangements\n* Hematological relapse after allo-HCT\n* 18 years or older\n\nExclusion Criteria:\n\n* no signed informed consent","ALL","18 Years",{"count":19,"type":20},20,"ESTIMATED","12 Months","OBSERVATIONAL","The white blood cells of patients with acute myeloid leukemia that have undergone allogeneic stem cell transplantation will be investigated. These are patient where the leukemia has returned after the transplantation.",[25],"Acute Myeloid Leukemia",[27,28,29],"acute myeloid leukemia","alloegeneic stem cell transplantation","menin inhibitor","RECRUITING","2026-06-06",{"date":33,"type":34},"2026-06-10","ACTUAL",{"date":36,"type":20},"2026-05-30",{"date":38,"type":20},"2027-05-30",{"name":40,"class":41},"University of Freiburg","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100597064","investigation-of-a-new-window-into-intracranial-pressure-venous-occlusion-pressure-of-the-isolated-periorbital-vein-100597064","NCT07053631","Investigation of a New Window Into Intracranial Pressure: Venous Occlusion Pressure of the Isolated Periorbital Vein","VOPxICP","Inclusion Criteria:\n\n* Medical indication to perform routine craniospinal CSF dynamic testing according to standard operative procedures\n* Aged 18-95\n* Willing and able to provide valid signed informed consent\n\nExclusion Criteria:\n\n* Patients with any known ongoing, or history of, abnormal CSF communication\n* Patients with any kind of prior intervention for CSF diversion\n* Patients with acute brain damage within the preceding 6 months\n* Patients with transdural surgery within the preceding 6 months\n* Head wounds or hematoma that could hinder access to measurement site\n* Any known pathological condition linked to the orbital socket influencing venous outflow","95 Years",{"count":52,"type":20},10,"INTERVENTIONAL",[55],"NA","Elevated intracranial pressure (ICP) occurs when pressure inside the skull rises above normal levels, potentially leading to brain damage or herniation. Monitoring ICP is critical for managing conditions like brain tumors, traumatic brain injury, and stroke. Current ICP monitoring methods are invasive and carry risks, including infection and brain damage. For less severe cases, lumbar puncture is a safer, less invasive alternative. This study explores the potential of a non-invasive method, using venous pressure near the eye, to estimate ICP. The goal is to assess whether the results from this non-invasive approach are similar to the invasive lumbar CSF pressure measurements.",[58,59],"Indication for CSF Dynamic Testing","Indication for CSF Infusion Test",[61,62],"ICP","non-invasive ICP assessment","2025-07-01",{"date":65,"type":34},"2025-07-08",{"date":67,"type":34},"2025-04-07",{"date":69,"type":20},"2025-12-08",{"name":40,"class":41},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":53,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":42},"100539251","phase-3-combination-of-hypothermia-and-thrombectomy-in-acute-stroke-100539251","NCT06301412","Combination of Hypothermia and Thrombectomy in Acute Stroke","Combination of Targeted Temperature Management and Thrombectomy After Acute Ischemic Stroke (COTTIS-2) - a Randomised Controlled Study","COTTIS-2","Inclusion Criteria:\n\n* Pre-stroke modified Rankin Scale (mRS) 0-2 \\[7-point scale rating from 0 (no symptoms) to 6 (dead)\\]\n* Acute ischemic stroke with NIHSS \\>5\n* Intracranial occlusion of the M1 or M2 segment of the middle cerebral artery (MCA) or internal carotid artery (ICA) or tandem occlusion on CT-angiography or MR-angiography with indication for endovascular treatment:\n* Time window 0-24h:\n\n  1. Last seen normal to groin puncture \\\u003C 6h: native CT or MRI-DWI with ASPECTS \\>5\n  2. Last seen normal to groin puncture 6-24h or unknown time window: significant mismatch imaging according to the eligibility criteria of the DEFUSE-3 trial\n\n     * Infarct core \\\u003C70ml (DWI oder CBF\\\u003C30%)\n     * Penumbra \\> 15ml (Tmax \\>6sec)\n     * Ratio penumbra\u002Fcore \\>1.8\n* with or without iv thrombolysis with rtPA\n\nExclusion Criteria:\n\n* Patients with an intranasal obstruction that prevents complete insertion of the nasal cannula should not be treated with the RhinoChill system.\n* Known severe hemorrhagic diathesis (International Normalized Ratio (INR) \\>3.0, partial thromboplastin time (PTT) \\> 70s, platelet count \\\u003C 50.000\u002Fμl)\n* Brain trauma or neurovascular surgery\u002Fintervention \\\u003C3 months\n* Severe infection\n* Pregnant women or women of childbearing potential (women of childbearing potential with negative pregnancy test may be included)\n* Known cerebral vasculitis\n* Proof of bleeding in cerebral CT or MRI (cerebral microbleeds in MRI \\[hypertensive or in the context of cerebral amyloid angiopathy\\] is permitted).\n* Known life expectancy \\\u003C 6 months",{"count":80,"type":20},400,[82],"PHASE3","The goal of this clinical trial is to test the combination of hypothermia and endovascular treatment in acute stroke patients with large vessel occlusion.\n\nThe main question it aims to answer is: does an additional cooling to 35°C result in a benefit on clinical outcome ? Participants receive immediate cooling using a noninvasive transnasal cooling technique (RhonoChill) and are maintained at 35°C for 6 hours after reopening of the vessel using surface cooling, and then slowly rewarmed.\n\nResearchers will compare the intervention group (hypothermia and endovascular treatment and best medical treatment including iv thrombolysis) and control group (only endovascular treatment and best medical treatment including iv thrombolysis) to see if additional hypothermia leads to a better outcome after 3 months without relevant complications.",[85,86,87],"Ischemic Stroke","Large Vessel Occlusion","Endovascular Treatment",[89,90],"hypothermia","neuroprotection","2025-01-02",{"date":93,"type":34},"2025-01-06",{"date":95,"type":34},"2024-07-07",{"date":97,"type":20},"2026-06-18",{"name":40,"class":41},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":119,"leadSponsor":121,"locationsCount":42},"100540944","spinal-csf-leaks-in-chronic-subdural-hematoma-100540944","NCT06323434","Spinal CSF Leaks in Chronic Subdural Hematoma","SPICE","Inclusion Criteria:\n\n1. Chronic subdural hematoma on imaging (CT\u002FMRI)\n2. Age: 18 years or older\n3. Informed consent\n\nExclusion Criteria:\n\n1. General contraindications for MRI examination (e.g., pacemaker wearers, implanted insulin, or pain pump, neurostimulator, etc.)\n2. Recurrent chronic subdural hematoma and previously performed diagnostics and treatment in compliance to the current cSDH SOP\n3. Severe brain injury, acute subdural hematoma, epidural hematoma, subarachnoid hemorrhage",{"count":107,"type":20},220,"Background: Chronic subdural hematoma (cSDH) is a type of intracranial bleeding, predominantly affecting the elderly and males, with an estimated incidence of 8\u002F100.000. The collection of subdural fluid expands slowly, leading eventually to brain tissue compression that results in neurological impairment such as seizures, cognitive decline, and paresis. Most patients need neurosurgical evacuation of the blood to improve and to prevent further, possibly permanent deterioration. Evidently, the cause of such a bleeding must be investigated and if possible treated, or preventive strategies need to be installed if possible. Spinal cerebrospinal fluid (CSF) leaks are a known cause of cSDH but are widely underdiagnosed in this population.\n\nThe spinal CSF leak causes CSF loss that leads to intracranial hypotension, expansion of intracerebral veins, and traction to the brain and the surrounding tissues. A cSDH is a severe complication of such a leak and occurs in about 30% of all cases with a predominance among the elderly. It is crucial to identify these patients with a spinal leak as treatment pathways differ essentially from patients without a leak. Some smaller studies indicated a prevalence of spinal CSF leaks among cSDH patients of 30% to 80% depending on selection criteria (age, extend of cSDH). Notably, the entity of the CSF-venous fistula, that has been discovered as recent as 9 years ago, and that by now is accounting for 20-25% of all spinal leaks, has not been considered in previous research on cSDH and spinal CSF leaks.\n\nCurrently, there is no prospective data on spinal CSF leaks in patients with cSDH. Establishment of such data is crucial to improve diagnostic and therapeutic algorithms for spinal CSF leaks in patients with cSDH.\n\nObjective: To prospectively assess the prevalence of spinal CSF leaks in patients with cSDH Methods: This is a prospective observational, monocentric study on patients admitted due to cSDH to the Department of Neurosurgery at the Medical Center of the University of Freiburg. Treatment and diagnostic procedures will follow standard protocols. The number of spinal CSF leaks will be assessed to generate the prevalence of spinal CSF leaks in this patient cohort. Furthermore, clinical data, the specific type of the CSF leak, and imaging parameters are assessed systematically to estimate the diagnostic value of these measures.",[110],"Chronic Subdural Hematoma",[112,113,114],"Spinal CSF leak","Spontaneous Intracranial Hypotension","CSF-venous fistula","2024-06-24",{"date":117,"type":34},"2024-06-26",{"date":115,"type":34},{"date":120,"type":20},"2026-12",{"name":40,"class":41},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":129,"maxAge":130,"enrollmentInfo":131,"targetDuration":133,"studyType":22,"phases":4,"briefSummary":134,"conditions":135,"keywords":138,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":42},"100376727","percutaneous-coronary-intervention-registry-fribourg-100376727","NCT04185285","Percutaneous Coronary Intervention Registry FRIBOURG","Cardio-FR","Inclusion Criteria:\n\n* All consecutive patients treated by percutaneous coronary intervention at our institution\n* Able to give informed consent and willing to participate\n\nExclusion Criteria:\n\n* Unwillingness to participate\n* Enable to provide inform consent","17 Years","120 Years",{"count":132,"type":20},3000,"10 Years","The registry aims to follow clinically all consecutive patients treated by percutaneous coronary interventions at hospital \\& university Fribourg.",[136,137],"Coronary Artery Disease","Percutaneous Coronary Intervention",[139],"PCI","2021-10-14",{"date":142,"type":34},"2021-10-22",{"date":144,"type":34},"2015-05-01",{"date":146,"type":20},"2027-09-01",{"name":40,"class":41},""]