[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Gaziantep\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":454},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,55,85,118,146,176,202,221,246,270,301,336,356,376,401,430],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100645075","comparison-of-the-effects-of-general-anesthesia-and-combined-spinal-epidural-anesthesia-on-ferroptosis-humanin-and-mots-c-levels-in-renal-transplantation-100645075",false,"NCT07678073","COMPARISON OF THE EFFECTS OF GENERAL ANESTHESIA AND COMBINED SPINAL-EPIDURAL ANESTHESIA ON FERROPTOSIS, HUMANIN, AND MOTS-C LEVELS IN RENAL TRANSPLANTATION","COMPARISON OF THE EFFECTS OF GENERAL ANESTHESIA AND COMBINED SPINAL-EPIDURAL ANESTHESIA ON FERROPTOSIS, HUMANIN, AND MOTS-C LEVELS IN RENAL TRANSPLANTATION: A PROSPECTIVE CONTROLLED STUDY","Inclusion Criteria:\n\n* Patients aged 18-70 years with American Society of Anesthesiologists (ASA) physical status I-III.\n* Patients scheduled for elective living-donor allogeneic kidney transplantation.\n* Patients receiving sevoflurane-based general anesthesia as the anesthetic technique.\n* Patients receiving combined spinal-epidural anesthesia as the anesthetic technique.\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 70 years.\n* Patients undergoing deceased-donor kidney transplantation.\n* Patients receiving total intravenous anesthesia (TIVA).\n* Patients who decline to participate in the study or are unable to provide informed consent.\n* Patients with American Society of Anesthesiologists (ASA) physical status IV or V.\n* Patients with a history of previous organ transplantation.\n* Patients with known or suspected mitochondrial disorders.\n* Patients with a history of chronic corticosteroid use.\n* Patients requiring red blood cell transfusion intraoperatively or within the first 24 postoperative hours.\n* Patients with a primary warm ischemia time \\>5 minutes, secondary warm ischemia time \\>30 minutes, or cold ischemia time \\>60 minutes.","ALL","18 Years","70 Years",{"count":20,"type":21},68,"ESTIMATED","INTERVENTIONAL",[24],"NA","Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes. Ferroptosis has recently emerged as a potential mechanism involved in ischemia-reperfusion injury, while the mitochondrial-derived peptides humanin and MOTS-c are thought to exert protective effects against oxidative stress. However, the effects of different anesthetic techniques on these biomarkers in kidney transplant recipients have not been investigated.\n\nThis prospective controlled study aims to compare the effects of sevoflurane general anesthesia (SGA) and combined spinal-epidural anesthesia (CSEA) on serum ferroptosis markers, humanin, and MOTS-c levels in adult kidney transplant recipients. Blood samples will be obtained perioperatively for biomarker analysis.\n\nThe primary objective of the study is to evaluate the effects of the anesthetic technique on serum ferroptosis markers, humanin, and MOTS-c levels. Secondary objectives include evaluating early graft function and postoperative outcomes by assessing the incidence of delayed graft function, postoperative serum creatinine levels, requirement for dialysis, urine output, length of hospital stay, and the association of these outcomes with perioperative biomarker levels.",[27,28,29,30,31],"Kidney Disease, End-Stage","Kidney Transplant","Kidney","Kidney Disease","Renal Transplant",[33,34,35,36,37,38,39,40,41],"GENERAL ANESTHESIA","REGIONAL ANESTHESIA","KIDNEY TRANSPLANTATION","CELLULAR STRESS RESPONSE","CELLULAR STRESS","ANESTHESIA","HUMANIN","MOTS-c","FERROPTOSIS","RECRUITING","2026-06-24",{"date":45,"type":46},"2026-07-01","ACTUAL",{"date":48,"type":46},"2026-03-01",{"date":50,"type":21},"2026-10-15",{"name":52,"class":53},"University of Gaziantep","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":68,"conditions":69,"keywords":74,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":4},"100641832","the-effect-of-reiki-applied-during-the-postpartum-period-on-the-quality-of-postpartum-recovery-comfort-and-mood-100641832","NCT07654881","THE EFFECT OF REIKI APPLIED DURING THE POSTPARTUM PERIOD ON THE QUALITY OF POSTPARTUM RECOVERY, COMFORT AND MOOD.","THE EFFECT OF REIKI APPLIED DURING THE POSTPARTUM PERIOD (AFTER CESAREAN SECTION) ON THE QUALITY OF POSTPARTUM RECOVERY, COMFORT AND MOOD.","Inclusion Criteria:\n\n* Ages 19-35\n* Literate and able to communicate\n* Those who gave birth after 37 weeks of gestation\n* Those who had a single or intrauterine delivery\n* Those who meet the inclusion criteria and volunteer to participate\n* Those residing within the central district of Gaziantep province\n* Those who received spinal\u002Fepidural anesthesia\n\nExclusion Criteria:\n\n* Having an infectious skin disease\n* Having a chronic illness (diabetes mellitus, hypertension, etc.)\n* Having complications related to the birth process\n* The baby not being present for any reason\n* Using sedative agents for any reason\n* Mothers with disabled babies\n* Having experienced an acute psychiatric attack","FEMALE","19 Years","35 Years",{"count":66,"type":21},80,[24],"The postpartum period, also defined as the fourth trimester of pregnancy, encompasses the approximately 6-8 week period following childbirth, during which the organs that underwent changes during pregnancy return to their previous state. This period is of great importance in terms of protecting the health of both mother and baby, meeting their care needs, and increasing their comfort. During the postpartum period, women experience physiological, psychological, and social changes; hormonal changes, assuming parental roles, changes in family dynamics, and increased responsibilities related to infant care can lead to adjustment difficulties. This can cause problems for the mother in both her own care and infant care.\n\nIn the postpartum period, mothers may experience various health problems such as pain, fatigue, sleep disturbances, infections, breastfeeding problems, hemorrhoids, constipation, urinary incontinence, depressive symptoms, and mood swings. Pain, in particular, arises due to uterine contractions, breast engorgement, nipple tenderness, and other complications, negatively affecting the mother's mobility, sleep patterns, social interaction, and quality of life. Furthermore, stress and adjustment problems experienced during the postpartum period can lead to serious psychological problems such as delayed maternal bonding, postpartum blues, postpartum depression, psychosis, and communication problems between couples.\n\nPharmacological and non-pharmacological methods are used in the management of these problems. However, due to the negative effects that pharmacological methods may have during breastfeeding, interest in complementary and alternative medicine practices has increased. Reflexology, aromatherapy, music therapy, acupressure, and Reiki are among these methods.\n\nReiki is an energy therapy method that aims to balance an individual's life energy and support the natural healing process, applied through touch or the placement of hands on specific points. Reiki application is reported to have positive effects on pain, stress, anxiety, sleep quality, and coping skills. Although it is one of the preferred methods for adapting to changes and reducing problems experienced in the postpartum period, studies directly examining the effects of Reiki application on postpartum recovery quality, comfort, and mood are quite limited. Due to its low cost, ease of application, and lack of side effects, Reiki is considered an important complementary care approach that can be used in the postpartum period.\n\nThe aim of this study is to determine the effect of face-to-face Reiki treatment on the quality of postpartum healing, comfort level, and mood in women who have had cesarean deliveries, on days 1, 2, and 7 of the postpartum period.",[70,71,72,73],"Postpartum Period","Reiki Therapy","Mood","Comfort",[75],"Reiki Therapy, Postpartum Period, Mood, Comfort, Recovery of Function","NOT_YET_RECRUITING","2026-06-12",{"date":79,"type":46},"2026-06-17",{"date":81,"type":21},"2026-06-15",{"date":83,"type":21},"2027-01-01",{"name":52,"class":53},{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":54},"100636387","internal-jugular-vein-collapsibility-index-for-predicting-post-induction-hypotension-100636387","NCT07565025","Internal Jugular Vein Collapsibility Index for Predicting Post-Induction Hypotension","The Value of Internal Jugular Vein Collapsibility Index in Predicting Hypotension Following General Anesthesia Induction in Patients Undergoing Elective Laparoscopic Cholecystectomy","IJV-CI","Inclusion Criteria:\n\n* Patients aged 18-65 years.\n* Patients with ASA (American Society of Anesthesiologists) physical status I, II, or III.\n* Patients scheduled to receive general anesthesia.\n* Patients scheduled for elective laparoscopic cholecystectomy.\n\nExclusion Criteria:\n\n* Patients with obesity (Body Mass Index \\> 35 kg\u002Fm²).\n* Patients with Atrial Fibrillation or other serious cardiac arrhythmias.\n* Patients with a history of neck surgery or any pathology preventing Internal Jugular Vein (IJV) measurement.\n* Patients with advanced heart failure (Ejection Fraction \\\u003C 40%).\n* Patients with severe valvular heart disease.\n* Patients with peripheral vascular disease.\n* Patients undergoing emergency surgery.\n* Patients who are unwilling to participate in the study.","65 Years",{"count":95,"type":21},42,"OBSERVATIONAL","This study aims to investigate whether the Internal Jugular Vein Collapsibility Index (IJV-CI), measured via ultrasonography, can predict hypotension (low blood pressure) that occurs after the induction of general anesthesia. Researchers will measure the diameter of the internal jugular vein in patients before surgery and compare these measurements with the blood pressure changes during the first minutes of anesthesia. The goal is to determine if IJV-CI can be used as a reliable, non-invasive tool to identify patients at higher risk of developing anesthesia-induced hypotension.",[99,100,101],"Hypotension","Anesthesia, General","Cholecystectomy, Laparoscopic",[103,104,91,105,106,107,108,109],"Internal Jugular Vein","Collapsibility Index","Ultrasonography","Post-induction Hypotension","Anesthesia Induction","Laparoscopic Cholecystectomy","Fluid Responsiveness","2026-04-27",{"date":112,"type":46},"2026-05-04",{"date":114,"type":21},"2026-05-01",{"date":116,"type":21},"2027-02",{"name":52,"class":53},{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":126,"sex":62,"minAge":4,"maxAge":4,"enrollmentInfo":127,"targetDuration":129,"studyType":96,"phases":4,"briefSummary":130,"conditions":131,"keywords":134,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":4},"100633491","operating-room-nurses-knowledge-of-medical-device-related-pressure-injuries-and-clinical-decision-making-skills-100633491","NCT07527377","Operating Room Nurses' Knowledge of Medical Device-Related Pressure Injuries and Clinical Decision-Making Skills","The Effect of Operating Room Nurses' Knowledge of Medical Device-Related Pressure Injuries on Clinical Decision-Making Skills: A Scenario-Based Multicenter Cross-Sectional Study","OR-MDRPI-KnowD","Inclusion Criteria:\n\n* Operating room nurses who have been working in operating rooms for at least one year Nurses who voluntarily agree to participate in the study Nurses who are able to understand and complete the data collection forms\n\nExclusion Criteria:\n\n* Nurses who withdraw from the study at any stage after providing consent Incomplete or missing data in the questionnaires",true,{"count":128,"type":21},165,"1 Day","This multicenter, scenario-based cross-sectional study aims to examine the effect of operating room nurses' knowledge of medical device-related pressure injuries on their clinical decision-making skills. The study will be conducted with approximately 165 operating room nurses working in three different hospitals in Gaziantep, Türkiye. Data will be collected using a descriptive information form, a validated medical device-related pressure injury knowledge scale, and a scenario-based clinical decision-making assessment form. The study will evaluate the relationship between nurses' knowledge levels and their clinical decision-making performance, as well as identify factors influencing these outcomes. The findings are expected to contribute to improving patient safety, enhancing nursing education, and supporting evidence-based clinical decision-making in perioperative care.",[132,133],"Medical Device-Related Pressure Injuries","Clinical Decision-Making",[135,136,133,137],"Medical Device-Related Pressure Injurie","Operating Room Nurses","Pressure Injury Prevention","2026-04-07",{"date":140,"type":46},"2026-04-14",{"date":142,"type":21},"2026-04-25",{"date":144,"type":21},"2026-12-31",{"name":52,"class":53},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":159,"conditions":160,"keywords":164,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":54},"100632331","phase-4-pain-control-during-eswl-using-non-opioid-analgesics-100632331","NCT07512297","Pain Control During ESWL Using Non-Opioid Analgesics","Comparative Evaluation of Non-Opioid Analgesics for Pain Control During Extracorporeal Shock Wave Lithotripsy: A Prospective Randomized Controlled Trial","ESWL-PAIN","Inclusion Criteria:\n\n* Adult patients (≥18 years) undergoing ESWL for urinary stone disease\n* Patients with kidney or ureteral stones indicated for ESWL\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known hypersensitivity or contraindication to ibuprofen, paracetamol, or tenoxicam\n\n  * Chronic pain conditions or regular use of analgesics\n  * Pregnancy or breastfeeding\n  * Severe renal or hepatic impairment\n  * Patients unable to complete pain assessment using VAS","75 Years",{"count":156,"type":21},160,[158],"PHASE4","This prospective randomized controlled trial aims to compare the analgesic efficacy of three non-opioid analgesics (ibuprofen, paracetamol, and tenoxicam) during extracorporeal shock wave lithotripsy (ESWL). All patients undergoing ESWL will be randomly assigned into four groups including a placebo group.\n\nPain intensity will be assessed using the Visual Analog Scale (VAS) at the 5th, 10th, 15th, and 20th minutes during the procedure. In addition to comparing analgesic efficacy, the study will evaluate patient-related and stone-related factors affecting pain perception, including body mass index, subcutaneous fat thickness, and stone density measured by Hounsfield Units.\n\nThe study also aims to assess the relationship between analgesic efficacy, energy levels applied during ESWL, and treatment outcomes such as stone-free rates. The findings may contribute to optimizing individualized pain management strategies and improving treatment efficiency in ESWL procedures.",[161,162,163],"Urolithiasis","Kidney Stones","Ureteral Stones",[165,166,167],"ESWL","pain","Analgesia","2026-04-05",{"date":170,"type":46},"2026-04-09",{"date":172,"type":21},"2026-04-01",{"date":174,"type":21},"2027-03-01",{"name":52,"class":53},{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":93,"enrollmentInfo":183,"targetDuration":4,"studyType":22,"phases":185,"briefSummary":186,"conditions":187,"keywords":191,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":199,"leadSponsor":201,"locationsCount":54},"100630216","effect-of-mindfulness-based-psychoeducation-in-depression-100630216","NCT07484789","Effect of Mindfulness-based Psychoeducation in Depression","The Effect Of Mındfulness-Based Psychoeducatıon On Symptom Severıty, Stress Tolerance, And Emotıon Regulatıon Dıffıculty İn Patıents Dıagnosed Wıth Depressıon","Inclusion Criteria:\n\n* Volunteering to participate in the study\n* Residing in Gaziantep city center\n* Not having any communication impediments\n* Being between 18 and 65 years of age\n* Being followed up as an outpatient with a diagnosis of depression according to DSM-V criteria\n* Having been receiving treatment for depression for at least 6 months\n* Being literate\n* Not having been enrolled in such an educational program related to their illness within the last 5 years\n\nExclusion Criteria:\n\n* Those diagnosed with another comorbid mental illness\n* Patients with mental conditions that make cooperation impossible, such as intellectual disability or dementia\n* Those who are illiterate\n* Patients who do not consent to the interview\n* Those receiving inpatient treatment",{"count":184,"type":21},70,[24],"Major depression is a mental illness that seriously threatens public health, leading to disability, reduced quality of life, economic burden, and premature death. It is estimated that 18.4% of the world's population lived with depression between 2005 and 2015, and it is projected to be a leading cause of global disease burden by 2030. Major depressive disorder manifests with symptoms such as decreased interest and desire, a depressed mood, increased or decreased sleep and appetite, feelings of worthlessness and guilt, decreased energy, suicidal thoughts and attempts, leading to significant impairment in functioning. Choosing the appropriate treatment for depression and taking measures to improve the individual's functionality quickly, shorten hospital stays, and reduce the number of hospitalizations are crucial. In addition to pharmacological treatment, clinical guidelines recommend the combined use of pharmacological and psychosocial interventions in the treatment of depression. The mindfulness-based cognitive therapy, which forms the basis of the psychoeducation planned for this study, was developed as an 8-week group approach. Theoretical studies examining emotion regulation mechanisms have indicated that mindful awareness is a fundamental mechanism for emotion regulation. The literature suggests a negative correlation between mindful awareness and the severity of depressive symptoms and difficulty in emotion regulation. Furthermore, despite numerous descriptive, correlational, and experimental studies on major depression, no studies have been found demonstrating the effect of mindful awareness-based psychoeducation on emotion regulation difficulties, distress tolerance, and symptom severity in patients diagnosed with major depression. This study, therefore, differs from existing research and will make a significant contribution to the literature.",[188,189,190],"Depression - Major Depressive Disorder","Mindfulness Based Stress Reduction","Psychiatric Nursing",[192,193,194],"depression","mindfulness","psychiatric nursing","2026-03-16",{"date":197,"type":46},"2026-03-20",{"date":172,"type":21},{"date":200,"type":21},"2027-10-01",{"name":52,"class":53},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":154,"enrollmentInfo":209,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":211,"conditions":212,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":218,"leadSponsor":220,"locationsCount":4},"100628227","prediction-of-post-induction-hypotension-using-plethysmographic-variability-index-during-diagnostic-laryngoscopy-100628227","NCT07458893","Prediction of Post-Induction Hypotension Using Plethysmographic Variability Index During Diagnostic Laryngoscopy","Prediction of Post-Induction Hypotension Using the Plethysmographic Variability Index in Patients Undergoing Diagnostic Laryngoscopy Under General Anesthesia","Inclusion Criteria:\n\n* Scheduled to undergo elective direct laryngoscopy under general anesthesia Body mass index (BMI) between 18 and 40 kg\u002Fm² ASA physical status classification I-III Provision of written informed consent after being informed about the study\n\nExclusion Criteria:\n\n* Severe arrhythmias Advanced heart failure Severe valvular heart disease Preoperative shock or hemodynamic instability requirement for continuous vasopressor or inotropic infusion Significant peripheral vascular disease affecting peripheral circulation",{"count":210,"type":21},110,"This prospective observational study aims to evaluate whether non-invasive hemodynamic parameters, including the plethysmographic variability index (PVI) and perfusion index (PI), can predict post-induction hypotension in patients undergoing diagnostic direct laryngoscopy under general anesthesia. Patients aged 18-75 years with ASA physical status I-III scheduled for elective direct laryngoscopy will be included. PVI and PI values will be recorded before anesthesia induction and in the early post-induction period. The relationship between these indices and the decrease in mean arterial pressure after induction will be analyzed to determine their predictive value for hypotension.",[213],"Post-Induction Hypotension","2026-03-04",{"date":216,"type":46},"2026-03-09",{"date":216,"type":21},{"date":219,"type":21},"2027-02-10",{"name":52,"class":53},{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":126,"sex":62,"minAge":4,"maxAge":4,"enrollmentInfo":228,"targetDuration":4,"studyType":22,"phases":230,"briefSummary":231,"conditions":232,"keywords":236,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":243,"leadSponsor":245,"locationsCount":4},"100627597","the-effect-of-the-health-belief-model-based-education-given-to-mothers-of-children-aged-9-15-on-hpv-knowledge-level-and-child-vaccination-100627597","NCT07450703","The Effect of the Health Belief Model-Based Education Given to Mothers of Children Aged 9-15 on HPV Knowledge Level and Child Vaccination","The Effect of Health Belief Model-Based Education on Mothers of Children Aged 9-15 Years: Impact on HPV Knowledge Level and Child Vaccination","Inclusion Criteria:\n\n* Literate and able to understand and speak Turkish\n* Mother of a child aged 9-15 years\n* Did not receive any HPV-related education in the past 6 months\n* Has not had HPV vaccination previously\n* Willing to participate voluntarily\n\nExclusion Criteria:\n\n* Presence of serious physical or cognitive impairment preventing participation\n* Refusal to provide informed consent\n* Already vaccinated against HPV\n* Already received HPV-related education within the last 6 months",{"count":229,"type":21},100,[24],"This study aims to examine the effects of education provided to mothers of children aged 9-15 within the framework of the Health Belief Model on mothers' knowledge, attitudes, and behaviors about Human Papillomavirus (HPV), and their willingness to have their children vaccinated against HPV. The study, designed with a randomized controlled experimental design, will be conducted at three different Family Health Centers in Gaziantep and will consist of both experimental and control groups. Mothers in the experimental group will receive a three-session visually supported education program prepared by Yıldız USCA, while the control group will receive routine information using HPV brochures from the Ministry of Health. Data collection tools include a personal information form, an HPV knowledge scale, and an HPV Health Belief Model scale.",[233,234,235],"Cancer , Healthy","HPV - Anogenital Human Papilloma Virus Infection","Health Belief Model",[237,238,239],"HUMAN PAPİLLOMA VIRUS","WOMEN HEALTH","VACCINE EDUCATİON",{"date":241,"type":46},"2026-03-05",{"date":172,"type":21},{"date":244,"type":21},"2026-12-01",{"name":52,"class":53},{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":250,"acronym":251,"eligibilityCriteria":252,"healthyVolunteers":126,"sex":16,"minAge":17,"maxAge":154,"enrollmentInfo":253,"targetDuration":129,"studyType":96,"phases":4,"briefSummary":255,"conditions":256,"keywords":258,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":4},"100625787","the-impact-of-endotracheal-cuff-pressure-assessment-using-a-cuff-pressure-manometer-compared-with-the-traditional-palpation-method-on-postoperative-outcomes-100625787","NCT07427173","The Impact of Endotracheal Cuff Pressure Assessment Using a Cuff Pressure Manometer Compared With the Traditional Palpation Method on Postoperative Outcomes","ECP","Inclusion Criteria:\n\n* Patients aged 18-75 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Body mass index (BMI) between 18 and 30 kg\u002Fm²\n* Undergoing surgery under general anesthesia\n* Successful endotracheal intubation on the first attempt -Provided written informed consent and willing to participate in the study-\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 75 years\n* American Society of Anesthesiologists (ASA) physical status IV-VI\n* Patients undergoing head and neck surgery\n* History of chronic pulmonary disease (e.g., asthma, chronic obstructive pulmonary disease)\n* Presence of preoperative sore throat\n* History of upper or lower respiratory tract infection within the past 2 weeks\n* Use of systemic steroids in the preoperative period\n* More than one attempt required for endotracheal intubation\n* Emergency surgeries\n* Refusal to participate in the study",{"count":254,"type":21},104,"The aim of this prospective observational study is to evaluate the effect of endotracheal cuff pressure management on postoperative complications in patients undergoing surgery under general anesthesia. Specifically, patients whose endotracheal cuff pressure is maintained at an optimal level using a manometer will be compared with those whose cuff pressure is assessed using the conventional palpation method.\n\nThe primary question the study aims to answer is whether maintaining endotracheal cuff pressure at an optimal level with a manometer reduces the incidence of postoperative airway-related complications compared with the classical palpation technique.",[257],"Postoperative Airway Complications",[259,260,261],"Postoperative airway complications","Endotracheal cuff pressure management","General anesthesia","2026-02-21",{"date":264,"type":46},"2026-02-24",{"date":266,"type":21},"2026-02-18",{"date":268,"type":21},"2026-09-01",{"name":52,"class":53},{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":278,"targetDuration":4,"studyType":22,"phases":280,"briefSummary":281,"conditions":282,"keywords":287,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":54},"100620938","kidney-transplant-immunosuppressive-therapy-adherence-trial-kite-100620938","NCT07364123","Kidney Transplant Immunosuppressive Therapy Adherence Trial (KITE)","Education and Telephone Counseling to Improve Adherence to Immunosuppressive Medication in Kidney Transplant Recipients: A Randomized Controlled Trial","KITE","Inclusion Criteria:\n\n* Adult kidney transplant recipients aged 18 years or older\n* At least 1 month post-kidney transplantation\n* Able to provide informed consent\n* Cognitively intact and oriented to person, place, and time\n* Able to communicate via telephone\n* Voluntarily willing to participate in the study\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Severe cognitive impairment preventing participation\n* Inability to communicate effectively (hearing or speech limitations without support)\n* Patients who do not meet the post-transplant time threshold (less than 1 month)\n* Patients unwilling or unable to participate in follow-up sessions",{"count":279,"type":21},60,[24],"This randomized controlled interventional study aims to evaluate the effect of structured education and telephone counseling on immunosuppressive medication adherence among kidney transplant recipients. Poor adherence to immunosuppressive therapy after kidney transplantation is a major risk factor for acute rejection, graft loss, and increased morbidity. Education and behavioral support interventions delivered by nurses may improve medication understanding, adherence behaviors, and self-management skills.\n\nIn this trial, 60 participants will be randomly assigned to either an intervention group receiving individualized education, an immunosuppressive medication adherence booklet, and scheduled telephone counseling sessions, or a control group receiving routine clinical care. Adherence will be assessed using the Immunosuppressive Medication Adherence Scale and biological monitoring through tacrolimus level variability over 8 weeks. Additional outcomes include changes in medication knowledge scores based on pre-test and post-test assessments.\n\nThe study will contribute evidence regarding whether nurse-led telephone counseling and structured education can enhance adherence, improve clinical follow-up, and support long-term graft success in kidney transplant patients.",[283,284,285,286],"Kidney Transplantation","Medication Non-Adherence","Immunosuppressive Therapy","Renal Transplant Recipients",[28,288,289,290,291,292],"Immunosuppressive Medication","Medication Adherence","Telephone Counseling","Patient Education","Tacrolimus Levels","2026-01-26",{"date":295,"type":46},"2026-01-28",{"date":297,"type":21},"2026-01-05",{"date":299,"type":21},"2026-08-15",{"name":52,"class":53},{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":312,"conditions":313,"keywords":319,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":54},"100622155","guided-visualization-meditation-for-reducing-surgical-stress-response-in-cardiac-surgery-patients-100622155","NCT07379944","Guided Visualization Meditation for Reducing Surgical Stress Response in Cardiac Surgery Patients","The Effect of Guided Visualization Meditation on Surgical Stress Response in Patients Undergoing Cardiac Surgery: A Nonrandomized Controlled Clinical Trial","GVM-CARDIO","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled to undergo open-heart surgery\n* ASA physical status I-II\n* First-time cardiac surgery\n* On-pump, median sternotomy technique planned\n* Mild to moderate intraoperative hypothermia protocol\n* No diagnosed psychiatric disorder\n* Not using psychotropic medications\n* No endocrine disorders affecting cortisol (e.g., Addison's disease, Cushing's syndrome)\n* Not taking corticosteroid medications\n* Glasgow Coma Score = 15 postoperatively\n* No perioperative complications that may interfere with participation\n* Able and willing to provide informed consent\n\nExclusion Criteria:\n\n* Prolonged or complicated surgery\n* Withdrawal of consent at any stage\n* Postoperative altered consciousness (GCS \\\u003C 15)\n* Perioperative administration of corticosteroids\n* Severe intraoperative complications\n* Surgery cancelled or rescheduled\n* Hearing impairment preventing participation in auditory intervention\n* Any condition clinically judged by the investigator to interfere with study participation",{"count":310,"type":21},72,[24],"This study aims to evaluate whether guided visualization meditation can reduce the surgical stress response in patients undergoing open-heart surgery. Surgical stress response includes changes in hormones, blood glucose, and anxiety levels that occur before and after major surgery. Guided visualization meditation is a non-invasive relaxation technique that uses calming audio instructions to help patients imagine peaceful scenes and reduce stress.\n\nIn this study, patients scheduled for cardiac surgery will be assigned to one of two groups: an intervention group that receives guided visualization meditation and a control group that receives standard care only. Patients in the intervention group will listen to an audio recording containing guided visualization and calming background music through headphones. Sessions will be provided twice on the day before surgery, twice on the day of surgery, and twice on the first postoperative day.\n\nTo evaluate the effects of the intervention, blood samples will be collected to measure cortisol, glucose, and insulin levels. Anxiety levels will be assessed using the State-Trait Anxiety Inventory (STAI-I and STAI-II), and pain will be measured using a visual pain scale. These measurements will be performed at three specific time points: one day before surgery, six hours after extubation, and one day post-surgery.\n\nThe goal of this research is to determine whether guided visualization meditation can help reduce stress-related physiological and psychological changes in patients undergoing cardiac surgery. If effective, this method may offer a simple, safe, and supportive strategy to improve recovery and overall patient well-being.",[314,315,316,317,318],"Cardiac Surgery","Surgical Stress Response","Coronary Artery Disease","Postoperative Stress","Anxiety",[320,321,322,323,324,325,326,327],"guided visualization","meditation","mind-body intervention","STAI","perioperative care","cardiac surgery patients","insulin resistance","blood glucose","2026-01-23",{"date":330,"type":46},"2026-02-02",{"date":332,"type":21},"2026-01-15",{"date":334,"type":21},"2027-03-31",{"name":52,"class":53},{"id":337,"slug":338,"hasResults":11,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":4,"eligibilityCriteria":342,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":343,"targetDuration":4,"studyType":22,"phases":345,"briefSummary":346,"conditions":347,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":355,"locationsCount":4},"100615950","the-impact-of-mobile-application-supported-monitoring-on-treatment-compliance-and-success-in-lifestyle-changes-in-hypertensive-patients-100615950","NCT07299266","The Impact of Mobile Application-Supported Monitoring on Treatment Compliance and Success in Lifestyle Changes in Hypertensive Patients","Doctoral Thesis Study","Inclusion Criteria:\n\n* Diagnosed with hypertension at least 6 months prior.\n* Willingness to voluntarily participate in the study.\n* Aged 18 years or older.\n* Ability to use a smartphone.\n* Ability to read and write (literate).\n\nExclusion Criteria:\n\n* Patients with other serious cardiovascular diseases (e.g., heart failure, cardiac arrhythmia).\n* Inability to use a smartphone (for the intervention group).\n* Pregnancy.\n* Withdrawal of consent or request to leave the study.\n* Presence of any diagnosed psychiatric disorder.",{"count":344,"type":21},40,[24],"Hypertension (HT) is defined as an arterial blood pressure persistently exceeding 140\u002F90 mmHg in repeated measurements. It is a systemic disease characterized by chronically elevated blood pressure, which can lead to severe health complications. Despite advancements in screening, diagnosis, and treatment methods, hypertension remains a leading risk factor for mortality and disability in both developed and developing countries. Globally, approximately 1.3 billion individuals are living with hypertension. It is projected that within the next two decades, hypertension will become the most significant modifiable risk factor for non-communicable diseases. International guidelines recommend ambulatory blood pressure monitoring (ABPM) and\u002For home blood pressure monitoring (HBPM) for the diagnosis of hypertension. It has been demonstrated that home and\u002For ambulatory blood pressure measurements provide superior prognostic information regarding target organ damage and cardiovascular risk compared to clinic-based measurements. Nevertheless, both ambulatory and home blood pressure monitoring have several well-known limitations, including patient comfort, sleep disturbance, accessibility, and cost.\n\nThe use of various mobile technologies has been evaluated in different settings to improve hypertension management in primary care services. Mobile monitoring can lead to significant reductions in blood pressure (BP), decrease all-cause and hypertension-related hospitalizations, lower all-cause mortality and costs, and enhance quality of life. Furthermore, technology-assisted BP self-monitoring interventions have demonstrated superior BP control outcomes when combined with nurse-led mobile support, physician intervention, and medication review. This research, grounded in the integration of digital health technologies into nursing care, aims to enhance treatment adherence and the success of lifestyle modifications in hypertensive patients through mobile application-supported monitoring. Through this approach, the patient-nurse interaction will be strengthened, and self-management skills will be supported via personalized feedback.",[348],"Hypertension","2025-12-09",{"date":351,"type":46},"2025-12-23",{"date":353,"type":21},"2026-01-01",{"date":244,"type":21},{"name":52,"class":53},{"id":357,"slug":358,"hasResults":11,"nctId":359,"briefTitle":360,"officialTitle":360,"acronym":4,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":22,"phases":364,"briefSummary":365,"conditions":366,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":368,"lastUpdatePostDateStruct":369,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":4},"100597428","effects-of-progressive-relaxation-exercises-applied-to-patients-with-ankylosing-spondylitis-on-pain-and-fatigue-levels-100597428","NCT07058363","Effects of Progressive Relaxation Exercises Applied to Patients With Ankylosing Spondylitis on Pain and Fatigue Levels","Inclusion Criteria:\n\n* Having AS diagnosis\n* Volunteering to participate in the study\n* Being over 18 years of age\n* Having internet access\n\nExclusion Criteria:\n\n* Having an orthopedic disability that prevents PGE\n* Being pregnant\n* Scoring 24 or less from the Mini Mental Test for individuals over 65 years of age\n* Wanting to leave the study\n* Having any psychiatric problems\n* Not using a communication tool that allows online interviews\n* Scoring \"0\" for pain and fatigue",{"count":363,"type":21},50,[24],"Ankylosing spondylitis (AS) is a chronic rheumatic disease with unique clinical, pathophysiological, radiographic and genetic features, the etiology of which is not known for sure, and is characterized by sacroiliac and spinal joint involvement. It is reported that this disease affects one in every 200 people, is usually diagnosed years after the onset of symptoms, and negatively affects quality of life. The prevalence of AS is between 0.2% and 1.1%, and symptoms begin before the age of 30 in approximately 80% of cases. The main complaints of patients diagnosed with AS include pain, joint stiffness, fatigue, and functional limitations of various degrees. Functional limitations resulting from inflammation and\u002For bone formations affect daily life activities, especially the person's ability to participate in leisure and domestic activities, and work productivity, and can limit social roles in the family and society. It is reported in the literature that regular PGE reduces pain and fatigue, facilitates the transition to sleep, and improves quality of life. In this context, this study aimed to evaluate the effect of PGE in reducing pain and fatigue frequently experienced by AS patients and to contribute to symptom management.",[367],"Ankylosing Spondylitis","2025-06-30",{"date":370,"type":46},"2025-07-10",{"date":372,"type":21},"2025-07-15",{"date":374,"type":21},"2027-01-15",{"name":52,"class":53},{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":11,"sex":16,"minAge":384,"maxAge":385,"enrollmentInfo":386,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":388,"conditions":389,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":54},"100588656","ckm-syndrome-prevalence-and-its-association-with-score-2-and-bri-100588656","NCT06944236","CKM Syndrome Prevalence and Its Association With SCORE-2 and BRI","Prevalence of Cardiovascular-Kidney-Metabolic (CKM) Syndrome and Its Relationship With SCORE-2 Risk Score and Body Roundness Index (BRI): A Study From Gaziantep, Turkey","CKM-PREV","Inclusion Criteria Age between 30 and 79 years Residence in Gaziantep, Türkiye\n\nAvailability of the following laboratory tests performed within the past 1 month:\n\nFasting glucose HbA1c Lipid profile (total cholesterol, LDL, HDL, triglycerides) Creatinine Estimated glomerular filtration rate (eGFR) Ability to provide informed consent\n\nExclusion Criteria Presence of severe physical or mental disability Hospitalization due to acute illness within the past 3 months Pregnancy","30 Years","79 Years",{"count":387,"type":21},400,"This cross-sectional study aims to determine the prevalence of Cardiovascular-Kidney-Metabolic (CKM) syndrome in a community-based adult population in Gaziantep, Türkiye. In addition to estimating the prevalence across CKM stages, the study investigates the associations between CKM syndrome and two key risk indicators: the SCORE-2 cardiovascular risk score and Body Roundness Index (BRI). Findings from this study will provide valuable insights into early cardiometabolic risk profiling and support the development of regionally tailored prevention strategies.",[390,391,392],"Metabolic Syndrome","Cardiovascular Diseases","Chronic Kidney Disease(CKD)","2025-04-17",{"date":395,"type":46},"2025-04-25",{"date":397,"type":21},"2025-06-01",{"date":399,"type":21},"2025-12-31",{"name":52,"class":53},{"id":402,"slug":403,"hasResults":11,"nctId":404,"briefTitle":405,"officialTitle":406,"acronym":4,"eligibilityCriteria":407,"healthyVolunteers":126,"sex":408,"minAge":63,"maxAge":409,"enrollmentInfo":410,"targetDuration":4,"studyType":22,"phases":412,"briefSummary":413,"conditions":414,"keywords":416,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":422,"lastUpdatePostDateStruct":423,"startDateStruct":425,"completionDateStruct":427,"leadSponsor":429,"locationsCount":4},"100570243","caffeine-mouth-rinse-on-salivary-immunoglobulin-a-lactoferrin-and-a-amylase-levels-100570243","NCT06704711","Caffeine Mouth Rinse on Salivary Immunoglobulin A, Lactoferrin and A-Amylase Levels","The Effect of Incremental Exercise After Caffeine Mouth Rinse on Salivary Immunoglobulin A, Lactoferrin and A-Amylase Levels","Inclusion Criteria:\n\n* Healthy men who have not had any previous injuries, do not have a chronic disease, do not use medication, do not smoke, and have played or are playing football as an amateur.\n\nExclusion Criteria:\n\nThose who have had any previous injury, have a chronic disease, use medication, or smoke.\n\n\\-","MALE","26 Years",{"count":411,"type":21},30,[24],"The goal of this clinical trial is to investigate the effects of the mouth rinse form of caffeine (400 mg) on salivary lactoferrin, α-amylase and secretory immunoglobulin-a levels after incremental exercise in young amateur football players. The main questions it aims to answer are:\n\n* Caffeine in mouth rinse form increases salivary immunoglobulin a after incremental exercise\n* Caffeine in mouth rinse form increases salivary lactoferrin after incremental exercise\n* Caffeine in mouth rinse form increases salivary a-amylase after incremental exercise.\n\nThis 3-session study will use a double-blind, randomized, placebo-controlled crossover experimental design. participants will complete three different treatments \\[caffeine (CAF), control (C) and placebo (PLA)\\] separated by at least 1 week. Baseline saliva samples will be collected while sitting in a chair and then:\n\n* CAF Group: They will rinse a solution containing a total of 400 mg caffeine (20 mL, 2% concentration) in the mouth for 20 seconds and try to continue the exercise against increasing resistance until exhaustion.\n* Control Group: Only rinse a solution containing a total of 400 caffeine (20 mL, 2% concentration) in the mouth for 20 seconds and receive no exercise treatment.\n* Placebo Group: They will rinse 20 mL of distilled water in the mouth for 20 s and try to continue the exercise against increasing resistance until exhaustion.\n\nSaliva samples will be collected at 6 different time points: 5 minutes before exercise (or caffeine mouth rinse) (T0-reference), immediately after caffeine mouth rinse (or immediately before exercise) (T1), 5 minutes\u002Fmidway through exercise (T2), and immediately after exercise (T3), 60 minutes after the end of exercise (T4) and 120 minutes after the end of exercise (T5).All data will be statistically analyzed using SPSS 25.0 software (Chicago, IL, USA) and expressed as mean ± standard deviation. Shapiro-Wilk and Levene tests will be used to determine whether the data are normally distributed and whether the variance is homogeneous. Repeated measures ANOVA test will be used to compare group means. If there is a difference between the groups as a result of the analysis, post-hoc tests will be used to find out from which group this difference originates. In cases where the data are not normally distributed, nonparametric test methods will be used. The significance level of the tests will be accepted as p\\\u003C0.05",[415],"Exercise Response",[417,418,419,420,421],"Sportomics","Salivary immunuglobulin-a","salivary lactoferrin","salivary a-amylase","caffeine","2024-11-21",{"date":424,"type":46},"2024-11-26",{"date":426,"type":21},"2024-11-15",{"date":428,"type":21},"2024-12-30",{"name":52,"class":53},{"id":431,"slug":432,"hasResults":11,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":436,"eligibilityCriteria":437,"healthyVolunteers":11,"sex":16,"minAge":438,"maxAge":439,"enrollmentInfo":4,"targetDuration":4,"studyType":440,"phases":4,"briefSummary":441,"conditions":442,"keywords":444,"overallStatus":448,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":4,"completionDateStruct":4,"leadSponsor":452,"locationsCount":453},"100559340","tension-type-headache-gene-expression-and-methylation-100559340","NCT06562855","Tension-Type Headache Gene Expression and Methylation","Gene Expression-methylation Profiling","TTH","Inclusion Criteria:\n\n* (ICHD)-3 criteria\n* Male and female\n* 17-82 years\n* not diagnosed with tension-type or other primary headaches\n\nExclusion Criteria:\n\n* Tension-type headache not diagnosed\n* below 16 ages\n* pregnant woman\n* subdural hematoma\n* intracranial mass","17 Years","82 Years","EXPANDED_ACCESS","Tension-type headache (TTH) refers to pain radiating from the forehead to the back of the head as a bilateral band. It often occurs without warning and spreads to the neck muscles. Patients describe it as tension, pressure, or dull pain. It is usually triggered by stress. The complexity of the processes is the biggest difficulty in diagnosing and treating TTH. Although there are genetic connections, there are no single responsible genes.",[443],"Tension-Type Headache, Unspecified, Intractable",[445,446,447],"Tension-Type Headache","Gene expression","Gene methylation","AVAILABLE","2024-08-16",{"date":451,"type":46},"2024-08-20",{"name":52,"class":53},2,""]