[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Georgia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":353},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,44,69,102,129,149,179,198,217,250,279,301,329],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100053559","cardiometabolic-effects-of-the-recommended-daily-pecan-intake-dose-100053559",false,"NCT07696403","Cardiometabolic Effects of the Recommended Daily Pecan Intake Dose","Cardiometabolic Effects of the Recommended Daily Pecan Intake Dose: A 12-Week Randomized Controlled Trial","Inclusion Criteria:\n\n* 25-75 year-old men and women at increased risk for cardiovascular disease. Increased risk for cardiovascular disease will be defined by either elevated cholesterol profiles -or- overweight\u002Fobesity.\n* Elevated cholesterol profiles will be defined as:\n* \"Borderline High\" and\u002For \"at risk\" in two or more of the following variables (total cholesterol: 180-239 mg\u002FdL, LDL cholesterol 110-159 mg\u002FdL, triglycerides 130-199 mg\u002FdL) --or-- \"High\" in total cholesterol (240 mg\u002FdL and higher), LDL (160 mg\u002FdL or higher), or triglycerides (between 200-350 mg\u002FdL).\n* Overweight\u002Fobesity will be defined by body mass index (overweight \\> 28 kg\u002Fm2 or obesity 30 kg\u002Fm2 or greater).\n\nExclusion Criteria:\n\n* Probable familial hypercholesterolemia, defined by: total cholesterol greater than 290 mg\u002FdL or LDL levels greater than 190 mg\u002FdL plus a family history of myocardial infarction (MI) before 50 years of age in a 2nd-degree relative or below age 60 in a 1st-degree relative.\n* Women on hormone replacement therapy less than 2 years.\n* Women who are pregnant or nursing\n* Individuals who regularly exercise more than 3h\u002Fw\n* Weight gain or loss of more than 5% body weight in the past 3 months\n* Plans to begin a weight loss\u002Fexercise regimen during the trial\n* History of medical or surgical events that could affect digestion or swallowing\n* Gastrointestinal surgeries, conditions, or disorders\n* Any chronic diseases (including moderate to severe asthma, chronic lung disease, and kidney disease)\n* Metabolic disease\n* Atherosclerosis\n* Previous MI or stroke\n* Cancer\n* Fasting blood glucose levels greater than 126 mg\u002FdL\n* Blood pressure greater than 180\u002F120 mmHg\n* Medication use affecting digestion, absorption, or metabolism (e.g. thyroid meds), lipid-lowering medications, medications for diabetes, steroid\u002Fhormone therapies, or current antibiotic cycles\n* Medically prescribed or special diets\n* Food allergies (specific to the foods in the study, including tree nuts, dairy, gluten, palm oil, and coconut oil)\n* Fish oil supplements\n* Individuals who regularly consume nuts and\u002For nut butter (defined as consumption of \\>2 servings (\\~56g) of tree nuts, nuts, or nut butter (e.g., peanut butter, almond butter) per week\n* Excessive alcohol use (greater than 3 drinks\u002Fday for men; greater than 2 drinks\u002Fday for women)\n* Tobacco or nicotine use\n* Underweight BMI (\\\u003C18.5 kg\u002Fm²)",true,"ALL","25 Years","75 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","Cardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States' growing disease burden. The bioactive compounds contained in tree nuts have been shown to beneficially affect cardiometabolic health outcomes. Pecans contain more total phenols, sterols, and flavonoids than any other tree nut. They also are a rich source of polyunsaturated fatty acids (PUFAs), fiber, vitamin A, vitamin E, folic acid, calcium, magnesium, phosphorus, potassium, and zinc. These bioactive components in pecans are likely the reason for the previously documented improvements in cardiometabolic health. This study aims to examine the impact of a low dose of pecans on changes in fasting and postprandial lipid metabolism\u002Fblood lipids and markers of chronic disease risk.\n\nThe specific aims of this study are to:\n\n* Examine the effect of pecan consumption at a dose of 6% of total energy needs for 12 weeks on fasting and postprandial blood lipids.\n* Examine the effect of pecan consumption at a dose of 6% of total energy needs for 12 weeks on other markers of chronic disease risk.\n\nParticipants will be asked to:\n\n* Consume pecans daily for 12 weeks or maintain their current habitual diet.\n* Attend two short visits at 4 and 8 weeks for fasting blood draws, body measurements, and to collect their next 4 weeks' supply of study materials.\n* Attend two longer (5 h) testing visits, which include eating a standard breakfast meal and having their blood drawn periodically before and after breakfast.\n\nResearchers will compare the Pecan and Control groups to examine the physiologic effects of incorporating a low dose of pecans into one's diet.",[28,29,30],"Nutrition, Healthy","Dyslipidemia","Overweight and Obesity","NOT_YET_RECRUITING","2026-07-09",{"date":34,"type":35},"2026-07-13","ACTUAL",{"date":37,"type":22},"2026-08",{"date":39,"type":22},"2029-07",{"name":41,"class":42},"University of Georgia","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100530942","steps-towards-osteoarthritis-prevention-100530942","NCT06193343","Steps Towards Osteoarthritis Prevention","Steps Towards Osteoarthritis Prevention: A Pilot Study","STOP","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* For children, signed and dated informed assent by child and parental permission form by parent\u002Fguardian to participate in the study\n* Underwent an anterior cruciate ligament reconstruction (ACLR) between 6-60 months prior to enrollment\n* Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study\n* Completed all other formal physical therapy and therapeutic exercise regimens, and will not be engaging in any other formal therapy for their ACLR during the study\n* Physician clearance for unrestricted activity\n* Owning a smartphone\n* Demonstrate \\\u003C 8,000 steps per day during the screening phase of aim 2 as assessed using the Actigraph Link monitor\n\nExclusion Criteria:\n\n* Underwent an ACLR revision surgery due to a previous anterior cruciate ligament (ACL) graft injury\n* A multiple ligament surgery was indicated with their ACL injury\n* A lower extremity fracture was suffered during the ACL injury\n* The participant has previously been diagnosed with any diseases that affect joints is present in either knee including knee osteoarthritis inflammatory arthritis\n* Pregnant or plans to become pregnant over next 4 months\n* Body mass index (BMI) ≥ 36 kg\u002Fm2\n* Unable to speak English\n* Cochlear implant\n* Metal in body (metal fragments, shrapnel, permanent make-up, body piercings that cannot be removed)\n* Claustrophobia\n* History of seizures\n* Pacemaker","16 Years","40 Years",{"count":55,"type":22},56,[25],"Optimal knee joint loading, which refers to the forces acting on the knee caused by daily activities such as daily steps, plays an essential role in maintaining knee articular cartilage health and reducing the risk of osteoarthritis (OA). After anterior cruciate ligament reconstruction (ACLR), individuals take fewer daily steps as compared to uninjured controls resulting in insufficient knee joint loading to joint tissues, but it is unclear how changes in daily steps impact knee joint cartilage health in OA development. Therefore, the overall single arm, longitudinal pre-test post-test study objective is to determine the mechanistic links between knee joint loading as measured by daily steps and comprehensive magnetic resonance imaging (MRI) measures of knee joint cartilage health post-ACLR. The central hypothesis is that individuals post-ACLR who take low daily steps will demonstrate deconditioned, less resilient cartilage characterized by poor tibiofemoral cartilage composition and greater cartilage strain.",[59],"Anterior Cruciate Ligament Injuries","RECRUITING","2026-04-23",{"date":63,"type":35},"2026-04-29",{"date":65,"type":35},"2024-09-23",{"date":67,"type":22},"2028-01-30",{"name":41,"class":42},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":16,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":83,"conditions":84,"keywords":90,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":43},"100632984","changes-in-24-hour-activity-cycle-behaviors-during-a-time-restricted-eating-intervention-in-college-aged-women-100632984","NCT07520786","Changes in 24-hour Activity Cycle Behaviors During a Time-Restricted Eating Intervention in College-Aged Women","DAWGS in Time-Restricted Eating and Activity Trends (DAWG-TREAT)","DAWG-TREAT","Inclusion Criteria:\n\n* Female undergraduate and graduate students\n* Enrolled full-time at University of Georgia\n* Aged 18-26 years\n\nExclusion Criteria:\n\n* having one of the following chronic diseases that maybe impacted by the diet changes: type 1 and 2 diabetes mellitus, cancer, cardiovascular diseases, hypertension, thyroid dysfunction, hepatic\u002Frenal impairment, inflammatory bowel disease and other gastrointestinal diseases,\n* report use of nicotine, thyroid medications, antidepressants, or anti-anxiety medications, melatonin\n* having clinically diagnosed sleep disorders\n* alcohol intake exceeds two drinks per day\n* clinically diagnosed or undiagnosed eating disorders\n* division-1 student athletes\n* pregnant or lactating or plan on getting pregnant within 6 months\n* report major ambulatory disorders,\n* recently (within the past two weeks) engaged in caloric restriction, timing-based dietary changes, weight loss regimens, or adhered to specialized diets such as ketogenic or paleo diets,\n* required to take medication with food, as these factors may interfere with sleep and physical activity outcomes or pose risks to participant health during restricted eating protocols. Students whose habitual eating time windows are \\\u003C10 hours will also not be eligible.","FEMALE","18 Years","26 Years",{"count":81,"type":22},36,[25],"Time-restricted Eating (TRE) is a dietary approach that limits food intake to 4 - 12-hour windows without intentionally altering diet quality. TRE has several benefits including modest reductions in body weight and fat mass, improved glucose control, and reduced inflammatory markers. While research supports the metabolic and weight related benefits of TRE, there is limited evidence of its effects on physical activity (PA), sedentary behavior (SB) and sleep - the core components of 24-hour Activity Cycle (24-HAC), which is a holistic framework that integrates the three health-related activities. TRE research has largely focused on clinical populations, leaving its feasibility and adherence in healthy younger adults understudied. Within this group, college students' misaligned circadian rhythms and unpredictable schedules may make adherence to TRE challenging, highlighting the need for research on its practicality in this group. These outcomes are also particularly important to investigate in women, considering that SB is more prevalent among college-aged women (69%) compared to men (46%). To address these issues, we will conduct a three-week intervention to study the effects of TRE on the 24-HAC outcomes. College aged women will be screened and enrolled, then assigned to either a control or TRE group. Participants in the TRE group will self-select the timing of their 8-hour eating window which they will maintain throughout the study (with compliance on at least six days per week needed to be considered adherent). The control group will receive a basic nutrition education at the start of the study and will have no restriction on eating times. 24 HAC behaviors will be measured continuously for one-week of baseline measurement and throughout the intervention by wrist-worn ActiGraph GT9X monitors. Participants will also record the timing of their first and last meal each day and receive periodic reminders to report their hunger and satiety ratings using visual analog scales.",[85,86,87,88,89],"Sleep Quality","Compliance","Physical Activity","Sedentary Behaviors","Sleep Duration",[91,92,93],"Time restricted eating","Sleep quality","24-Hour activity cycle","2026-04-02",{"date":96,"type":35},"2026-04-09",{"date":98,"type":35},"2026-02-01",{"date":100,"type":22},"2027-04",{"name":41,"class":42},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":16,"sex":17,"minAge":78,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":118,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":43},"100473625","neuroimaging-approaches-to-improve-prediction-of-smoking-initiation-and-nicotine-escalation-in-young-adult-ends-users-100473625","NCT05447325","Neuroimaging Approaches to Improve Prediction of Smoking Initiation and Nicotine Escalation in Young Adult ENDS Users","Neuroimaging Approaches to Improve Prediction of Smoking Initiation and Nicotine Use Escalation Among Young Adult Electronic Nicotine Delivery Systems Users","Inclusion Criteria:\n\n* used e-cigarettes or other vaping devices at least 3 days during the past 30 days\n* did not smoke a cigarette, even one or two puffs, during the past 30 days\n* Magnetic resonance imaging (MRI) compatible and safe\n\nExclusion Criteria:\n\n* used e-cigarettes or other vaping devices for less than 3 days during the past 30 days\n* any use of cigarettes during the past 30 days\n* history of a major neurological, psychiatric, or medical disorder\n* MRI contraindications","29 Years",{"count":111,"type":22},180,[25],"180 young adult vapers who are not current smokers will participate in a baseline functional magnetic resonance imaging (fMRI) experiment, prospectively linked to a 1-year randomized controlled trial. Baseline fMRI tasks will probe critical neurocognitive markers with high potential to account for individual differences in nicotine use prognosis and responsiveness to anti-vaping public service announcements (PSAs). Participants will be assigned randomly to a survey-only control condition, or one of two intervention orders, Regular PSA then Flavor PSA, and Flavor PSA then Regular PSA (n=60 each) in a 1-year counterbalanced crossover design. Every week intervention groups will receive anti-vaping PSAs either do not specifically address harms associated with vaping flavors (regular PSAs) or PSAs with a theme focusing on the harms of flavored vape products (flavor PSAs). Participants of the intervention groups will switch PSA exposure condition after 6 months. Their evaluations of the PSAs will be assessed with brief weekly online surveys. The links to the weekly online surveys will be sent via e-mail and text which allow them to access the surveys using any device with an internet browser. During the survey, the PSA of that week will first be displayed to PSA groups (n=120), followed by a query to provide message evaluation. Afterward, the survey questions will also assess their e-cigarette, cigarette, other tobacco use, and nicotine dependence, during the past week. The control group (n=60) will complete the surveys without viewing PSAs. In-person assessments at 3, 6, 9, and 12 months will biochemically confirm nicotine exposure.",[115,116,117],"Message Exposure (Sequence: Regular Then Flavor)","Message Exposure (Sequence: Flavor Then Regular)","No Message Exposure (Control Condition)",[119,120],"health message intervention","randomized controlled trial","2026-03-30",{"date":123,"type":35},"2026-04-03",{"date":125,"type":35},"2022-07-15",{"date":127,"type":22},"2026-07-31",{"name":41,"class":42},{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":136,"targetDuration":4,"studyType":23,"phases":138,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":43},"100611886","intermittent-cottonseed-oil-consumption-100611886","NCT07246408","Intermittent Cottonseed Oil Consumption","Intermittent Cottonseed Oil Consumption on Cardiovascular Disease Risk Reduction","Inclusion Criteria:\n\n* 25-75 year-old men and women at increased risk for cardiovascular disease. Increased risk for cardiovascular disease will be defined by either elevated cholesterol profiles -or- overweight\u002Fobesity.\n* Elevated cholesterol profiles will be defined as:\n* \"Borderline High\" and\u002For \"at risk\" in two of more of the following variables (total cholesterol: 180-239 mg\u002FdL, LDL cholesterol 110-159 mg\u002FdL, triglycerides 130-199 mg\u002FdL) --or--\n* \"High\" in total cholesterol (240 mg\u002FdL and higher), LDL (160 mg\u002FdL or higher), or triglycerides (between 200-350 mg\u002FdL).\n\nExclusion Criteria:\n\n* Probable familial hypercholesterolemia, defined by: total cholesterol greater than 290 mg\u002FdL or LDL levels greater than 190 mg\u002FdL plus a family history of myocardial infarction (MI) before 50 years of age in a 2nd-degree relative or below age 60 in a 1st-degree relative.\n* Women on hormone replacement therapy less than 2 years.\n* Women who are pregnant or nursing\u002Fbreastfeeding\n* individuals who regularly exercise more than 3h\u002Fw\n* weight gain or loss of more than 5% body weight in the past 3 months\n* plans to begin a weight loss\u002Fexercise regimen during the trial\n* history of medical or surgical events that could affect digestion or swallowing\n* gastrointestinal surgeries, conditions, or disorders\n* any chronic diseases (including moderate to severe asthma, chronic lung disease, and kidney disease),\n* metabolic disease\n* atherosclerosis\n* previous MI or stroke\n* cancer\n* fasting blood glucose levels greater than 126 mg\u002FdL\n* blood pressure greater than 180\u002F120 mmHg\n* medication use affecting digestion, absorption, or metabolism (e.g. thyroid meds), lipid-lowering medications, medications for diabetes, steroid\u002Fhormone therapies, or current antibiotic cycles\n* medically prescribed or special diets\n* Food allergies (specific to the foods in the study, including soy, dairy, gluten, Yellow No. 5, cottonseed oil, palm oil, and coconut oil)\n* fish oil supplements\n* excessive alcohol use (greater than 3 drinks\u002Fday for men; greater than 2 drinks\u002Fday for women)\n* tobacco or nicotine use\n* underweight BMI (\\\u003C18.5 kg\u002Fm²)",{"count":137,"type":22},75,[25],"Cardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States' growing disease burden. Cottonseed oil (CSO) is found readily in the food supply, and the investigator's previous studies have demonstrated that incorporating CSO into the diet is sufficient to improve fasting and postprandial blood lipids and other markers of chronic disease risk in both healthy and at-risk populations. This study aims to examine the impact of intermittent CSO consumption at different doses (consumed three times per week (3x\u002Fwk)) on changes in fasting and postprandial lipid metabolism\u002Fblood lipids and markers of chronic disease risk.\n\nThe specific aims are: \\*Examine the impact of intermittent CSO consumption (3x\u002Fweek) at two different doses on fasting and postprandial lipids. \\*Examine the impact of intermittent CSO consumption (3x\u002Fweek) at two different doses on other markers of chronic disease risk.\n\nParticipants will be asked to:\n\n\\*Consume provided meal replacement shakes and snacks 3 times per week for 56 days. \\*Attend three bi-weekly (every other week) short visits for fasting blood draws, body measurements, and collection of the next two weeks' study materials. \\*Attend two longer (5.5h) testing visits, which include eating a standardized breakfast meal and having blood drawn periodically before and after breakfast.\n\nResearchers will compare CSO-30, CSO-20, and Control groups (receiving no oil) to see if intermittent CSO consumption imparts the same health benefits as previously shown with daily doses of CSO.",[29,30,28],"2026-01-21",{"date":143,"type":35},"2026-01-23",{"date":145,"type":35},"2026-01-16",{"date":147,"type":22},"2029-05",{"name":41,"class":42},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":16,"sex":17,"minAge":78,"maxAge":4,"enrollmentInfo":156,"targetDuration":4,"studyType":23,"phases":158,"briefSummary":159,"conditions":160,"keywords":164,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":43},"100577546","trauma-informed-resilience-based-telehealth-intervention-for-improving-hiv-prevention-and-hcv-care-for-persons-who-inject-drugs-in-the-deep-south-pilot-testing-aim3-100577546","NCT06799702","Trauma-informed, Resilience-based Telehealth Intervention for Improving HIV Prevention and HCV Care for Persons Who Inject Drugs in the Deep South (Pilot Testing: Aim3)","Trauma-informed, Resilience-based Telehealth Intervention for Improving HIV Prevention and HCV Care for Persons Who Inject Drugs in the Deep South","Inclusion Criteria:\n\n* People who actively inject drugs verified by visible injection stigmata (needle tracks)\n* HIV negative\n* Adult (≥18 years)\n* lives in rural areas\n\nExclusion Criteria:\n\n* Living with HIV\n* Lives in urban areas\n* Not proficient in English",{"count":157,"type":22},50,[25],"Evaluate the feasibility, acceptability, and usability of the intervention (primary outcomes) and coping skills and resilience (secondary outcomes) of the telehealth intervention over two months (8 weekly sessions) in a waitlist-controlled, randomized pilot trial using a cross-over design among 40 PWID. The primary outcomes will be feasibility, acceptability, and usability of the intervention. Secondary outcomes will be increased coping skills and resilience, which in turn, will increase status neutral HIV and HCV care and MOUD uptake (longer-term outcomes). Outcomes will be assessed using pre- and post-intervention surveys.",[161,162,163],"HIV Pre-exposure Prophylaxis","HEPATITIS C (HCV)","Opioid Use Disorder",[165,166,167,168,169,170],"HIV Pre-Exposure Prophylaxis","Hepatitis C Virus","Medications for Opioid Use Disorder","People who inject drugs (PWID)","Deep South","Telehealth Intervention","2025-12-17",{"date":173,"type":35},"2025-12-18",{"date":175,"type":22},"2026-08-01",{"date":177,"type":22},"2028-07-31",{"name":41,"class":42},{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":16,"sex":77,"minAge":78,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":23,"phases":188,"briefSummary":189,"conditions":190,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":195,"leadSponsor":197,"locationsCount":43},"100606304","optimizing-prep-uptake-for-african-american-women-in-the-south-by-empowering-women-to-make-informed-hiv-prevention-and-sexual-health-choices-100606304","NCT07173816","Optimizing PrEP Uptake for African American Women in the South by Empowering Women to Make Informed HIV Prevention and Sexual Health Choices","EMPOWER","Inclusion Criteria:\n\n1. Identification as cis-gendered Black woman;\n2. Age 18 and older;\n3. Engaging in risky sexual behavior in prior 3 months (condomless vaginal or anal sex with a non-main partner, or a partner with known or suspected risk behavior such as injection drug use or HIV\u002FSTI, multiple sex partners, transactional sex);\n4. Access to a device with a screen, a web browser, and adequate internet speed (e.g., smartphone, computer) for videoconferencing;\n5. Able to speak and read English; and\n6. No plans to leave the Atlanta, GA area during the duration of study participation.\n\nExclusion Criteria:\n\n1. Cognitive or mental health condition that limits the ability to provide informed consent;\n2. Self-reported use of PrEP or PEP medication in the past three months;\n3. Unable to speak and read English; and\n4. Currently living with HIV.",{"count":187,"type":22},80,[25],"Pilot testing of EMPOWER, a group sexual health intervention, to increase uptake and persistence of PrEP",[161],"2025-09-10",{"date":193,"type":35},"2025-09-15",{"date":175,"type":22},{"date":196,"type":22},"2027-08-31",{"name":41,"class":42},{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":205,"targetDuration":4,"studyType":23,"phases":206,"briefSummary":207,"conditions":208,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":43},"100545468","cottonseed-oil-versus-matched-pufa-effects-100545468","NCT06382298","Cottonseed Oil Versus Matched PUFA Effects","Health Effects of Cottonseed Oil Versus Matched Composition Diets in Humans","Inclusion Criteria:\n\n* 25-75 year-old men and women at increased risk for cardiovascular disease. Increased risk for cardiovascular disease will be defined by either elevated cholesterol profiles -or- overweight\u002Fobesity.\n* Elevated cholesterol profiles will be defined as:\n\n-\"Borderline High\" and\u002For \"at risk\" in two of more of the following variables (total cholesterol: 180-239 mg\u002FdL, LDL cholesterol 110-159 mg\u002FdL, triglycerides 130-199 mg\u002FdL) --or--\n\n* \"High\" in total cholesterol (240 mg\u002FdL and higher), LDL (160 mg\u002FdL or higher), or triglycerides (between 200-350 mg\u002FdL).\n\nOverweight\u002Fobesity will be defined by body mass index \\>25 kg\u002Fm².\n\nExclusion Criteria:\n\n* Probable familial hypercholesterolemia, defined by: total cholesterol greater than 290 mg\u002FdL or LDL levels greater than 190 mg\u002FdL plus a family history of myocardial infarction (MI) before 50 years of age in a 2nd-degree relative or below age 60 in a 1st-degree relative.\n* Women on hormone replacement therapy less than 2 years.\n* Women who are pregnant\n* individuals who regularly exercise more than 3h\u002Fw\n* weight gain or loss of more than 5% body weight in the past 3 months\n* plans to begin a weight loss\u002Fexercise regimen during the trial\n* history of medical or surgical events that could affect digestion or swallowing\n* gastrointestinal surgeries, conditions, or disorders\n* any chronic diseases (including moderate to severe asthma, chronic lung disease, and kidney disease),\n* metabolic disease\n* atherosclerosis\n* previous MI or stroke\n* cancer\n* fasting blood glucose levels greater than 126 mg\u002FdL\n* blood pressure greater than 180\u002F120 mmHg\n* medication use affecting digestion an absorption, metabolism (e.g. thyroid meds), lipid-lowering medications, medications for diabetes, steroid\u002Fhormone therapies, or current antibiotic cycles\n* medically prescribed or special diets\n* Food allergies (specific to the foods in the study, including wheat, dairy, and cottonseed oil)\n* fish oil supplements\n* excessive alcohol use (greater than 3 drinks\u002Fday for men; greater than 2 drinks\u002Fday for women)\n* tobacco or nicotine use\n* underweight BMI (\\\u003C18.5 kg\u002Fm²)",{"count":21,"type":22},[25],"Cardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States' growing disease burden. Cottonseed oil (CSO) is found readily in the food supply, and the investigator's previous studies have demonstrated that incorporating CSO into the diet is sufficient to improve fasting cholesterol profile and improve postprandial lipid and\u002For glycemic responses in both healthy, and at-risk populations. This study aims to compare CSO to a fatty acid composition-matched diet, on changes in fasting and postprandial lipid metabolism and markers of chronic disease risk.\n\nThe specific aims are:\n\n* Examine the impact of CSO vs. PUFA on fasting and postprandial lipids.\n* Examine the impact of CSO on other markers of chronic disease risk.\n\nParticipants will be asked to:\n\n* Consume provided meal replacement shakes daily for 28-days.\n* Attend three weekly short visits for fasting blood draws, body measurements, and collect the next week of study materials,\n* Attend two longer (5.5h) testing visits which include eating a standardized breakfast meal and having blood drawn periodically before and after breakfast.\n\nResearchers will compare CSO vs. PUFA and control groups (receiving a mixture of oils) to see if CSO is unique in imparting health benefits when compared with similar matched oil diets.",[29,30,28],"2025-08-12",{"date":211,"type":35},"2025-08-17",{"date":213,"type":35},"2024-08-31",{"date":215,"type":22},"2028-05",{"name":41,"class":42},{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":16,"sex":17,"minAge":78,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":236,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":43},"100593929","couple-based-crisis-safety-planning-100593929","NCT07012824","Couple-Based Crisis Safety Planning","Couple-Based Crisis Response Planning for Veterans","CRP-C","Inclusion Criteria:\n\n* (At least) One participant from the couple must have Veteran status\n* Currently resides in Georgia\n* English speaking\n* The Veteran must own a smartphone\n* Veteran must have experienced crisis symptoms in the past three months. At least 1 symptom of entrapment, and at least 1 symptom from 2 of the associated disturbance categories \\[i.e. affective disturbance, loss of cognitive control, hyperarousal, or social withdrawal\\]\n* Currently be in a committed relationship for at least one year\n* The Veteran must be able to present a copy of DD form 214 (Certificate of Release or Discharge from Active Duty issued by the U.S. Department of Defense)\n\nExclusion Criteria:\n\n* Non-English speaking\n* Under 18 years of age\n* Resides in a different state than Georgia\n* Either partner reports injury or fear resulting from intimate partner violence in the past three months.\n* Participants who meet study criteria for imminent suicide risk Depressive Symptom Index - Suicidality Subscale (Joiner et al., 2002), defined as a DSI- SS score of 7 or greater, or selecting \"3\" on items B \\[formulated plan\\] or D \\[constant urge to kill self (I. H. Stanley et al., 2021)",{"count":226,"type":22},100,[25],"Suicide is a leading cause of death in Veterans. Suicide rates among Veterans have increased approximately 36% from 2001 to 2020. Veterans are at increased risk for suicide compared to non-Veterans, with the rate of suicide death being 57.3% higher for Veterans than non-Veterans. The present study will pilot test a virtual couple-based crisis response plan (CRP-C) for Veterans in order to reduce crisis symptoms and decrease suicide risk.",[230,231,232,233,234,235],"Suicidal Ideas","Suicidal Ideation","Crisis; Emotional","Suicide Attempts","Suicidal and Self-injurious Behaviour","Suicidal Impulses",[237,238,239,240,241],"Veteran safety","Suicide risk","Crisis safety plan","Suicide crisis","intervention","2025-06-08",{"date":244,"type":35},"2025-06-10",{"date":246,"type":22},"2025-06",{"date":248,"type":22},"2027-08",{"name":41,"class":42},{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":4,"eligibilityCriteria":256,"healthyVolunteers":11,"sex":17,"minAge":78,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":23,"phases":259,"briefSummary":260,"conditions":261,"keywords":263,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":278},"100591984","renewed-recovery-a-pilot-test-of-a-web-based-mindfulness-based-relapse-prevention-continuing-care-intervention-for-alcohol-use-disorder-100591984","NCT06987526","Renewed Recovery: a Pilot Test of a Web-Based Mindfulness-Based Relapse Prevention Continuing Care Intervention for Alcohol Use Disorder","Renewed Recovery: a Pilot Test of a Web-Based Mindfulness-Based Relapse Prevention Continuing Care Intervention for Individuals With Alcohol Use Disorder","Inclusion Criteria:\n\n* Age 18 or older\n* Currently leaving standard outpatient treatment within 1 week of the scheduled intervention start date, or has completed standard outpatient treatment within the past month\n* Has access to the internet\n* Scored 8 or above on the Alcohol Use Disorders Identification Test (AUDIT), or self-identifies as having been in treatment for alcohol use\n\nExclusion Criteria:\n\n* Currently experiencing psychosis\n* Currently experiencing dementia\n* Does not have access to the internet\n* Has not recently completed or left standard outpatient treatment within the specified timeline\n* Does not meet criteria for alcohol use disorder",{"count":258,"type":22},30,[25],"This study aims to design, implement, and evaluate a pilot test of a web-based Mindfulness-Based Relapse Prevention (MBRP) continuing care intervention to support individuals with alcohol use disorder (AUD) exiting standard outpatient treatment. Guided by the Centre for eHealth and Wellbeing Research (CeHRes) roadmap, the project follows a structured framework for digital intervention development: (1) contextual inquiry, (2) value specification, (3) design, (4) operationalization, and (5) summative evaluation. Contextual inquiry is defined as gathering information from the intended users and the environment in which the technology will be implemented. The next step, value specification, is defined as the quantification of the values of the key stakeholders, where the user requirements for the technology and the most favorable solutions emerge. This process elaborates on what was discovered in the contextual inquiry step and an analytical hierarchy is conducted to assign quantifiable values to the stakeholders' priorities for the intervention. Design is the step defined as the process of building prototypes of the technology that fit with the values and requirements of the stakeholders, and then testing the prototype in realistic situations. Operationalization is the implementation of the intervention. The final step, summative evaluation, is the assessment of the intervention's impact.\n\nThe research team plans to conduct a needs assessment (Aim 1a), develop (Aim 1b), implement (Aim 2a), and evaluate (Aim 2b) a pilot test of a web-based MBRP continuing care intervention, named \"Renewed Recovery\", targeting individuals exiting standard outpatient treatment for alcohol.\n\nAim 1: Design a web-based mindfulness continuing care intervention.\n\nAim 1a: Conduct a community needs assessment. To understand the need for such an intervention, semi-structured qualitative interviews with program administrators (n=3) from partnering substance use treatment facilities will be conducted (contextual inquiry). To better understand the recovery journey after exiting standard outpatient treatment, semi-structured interviews with individuals (n\\~10) who have been in treatment more than once will be conducted (contextual inquiry). After interviewing the 2 stakeholder groups, a meeting will be held to determine their list of priorities for this project (value specification).\n\nAim 1b: Develop the intervention website (design). The website for the intervention will be created by creating multiple wireframe iterations and presenting them to the stakeholders to determine the best formatting. The curriculum on the site will be modeled after the original MBRP curriculum. After coming to a consensus on the best version of the website, a usability test will be conducted of a newly created prototype with the same 10 individuals who identified as having been in treatment more than once. A quantitative survey will be employed and a focus groups will be held to assess the usability, equitability, enjoyability, and usefulness of the website.\n\nAim 2: Implement and evaluate the pilot test at partnering treatment facilities.\n\nAim 2a: Implement the pilot test of the web-based MBRP continuing care intervention (operationalization). After altering the intervention based on the usability test, the program will begin to be implemented. 30 people (3 groups of 10) will. Be recruited to participate in the intervention that will be 8 weeks in length (1 module per week, for a total of 8 modules), composed of a self-guided curriculum of text and videos, as well as two zoom sessions to practice meditating as a group.\n\nAim 2b: Evaluate the pilot test to determine process and behavior outcomes (summative evaluation). To measure process outcomes, surveys will be employed asking about the usability, equitability, enjoyability, and usefulness of the website as well as their overall satisfaction with the intervention. Recruitment and retention rates will be another identifier of process outcomes. To measure behavior outcomes, participants will be given a multitude of measures at baseline to measure relapse, anxiety, depression, self-efficacy, coping mechanisms, social support, acceptance, mindfulness, and reactivity to triggers. Analysis of these measures will be done via multilevel modeling. These measures will also be given at the completion of the program and at 3 months after completion.",[262],"Alcohol Use Disorder (AUD)",[264,265,266,267,268,269],"alcohol use disorder","recovery","continuing care","web-based","mindfulness-based relapse prevention","addiction","2025-05-23",{"date":272,"type":35},"2025-05-30",{"date":274,"type":35},"2025-05-14",{"date":276,"type":22},"2026-05-01",{"name":41,"class":42},2,{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":11,"sex":17,"minAge":78,"maxAge":285,"enrollmentInfo":286,"targetDuration":4,"studyType":23,"phases":288,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":43},"100394296","cognitive-training-for-emotion-regulation-in-psychotic-disorders-100394296","NCT04414215","Cognitive Training for Emotion Regulation in Psychotic Disorders","Inclusion Criteria:\n\n* diagnostic and statistical manual fifth edition diagnosis of schizophrenia or schizoaffective disorder\n* 18-60 years old\n* speaks English\n* premorbid intelligence quotient \\> 70\n* clinically stable as indicated by no antipsychotic medication changes in the last month or if on depot, no change in the past 2 months.\n\nExclusion Criteria:\n\n* history of intellectual disability or neurological disorder\n* history of traumatic brain injury with loss of consciousness \\> 10 minutes or behavioral sequelae\n* substance use disorder within the last 6 months (other than nicotine)\n* 4\\) endorsement of MRI exclusion factors","60 Years",{"count":287,"type":22},70,[25],"The current study examines the efficacy of a cognitive training intervention for improving emotion regulation in psychotic disorders. it is hypothesized that the cognitive training program will enhance prefrontal activation, leading to enhanced emotion regulation.",[291,292],"Schizophrenia","Schizo Affective Disorder","2025-02-04",{"date":295,"type":35},"2025-02-05",{"date":297,"type":35},"2020-06-01",{"date":299,"type":22},"2029-12-31",{"name":41,"class":42},{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":16,"sex":17,"minAge":78,"maxAge":19,"enrollmentInfo":308,"targetDuration":4,"studyType":23,"phases":310,"briefSummary":312,"conditions":313,"keywords":315,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":43},"100548727","phase-2-effects-of-an-antioxidant-supplement-on-blood-vessel-health-100548727","NCT06424756","Effects of an Antioxidant Supplement on Blood Vessel Health","Role of Mitochondria-derived Oxidative Stress on Microvascular Endothelial Function in Healthy Non-Hispanic Black and White Adults","Inclusion Criteria:\n\n* Self-identify as either non-Hispanic Black or non-Hispanic White.\n* Men and women 18-75 years old.\n* Non-hypertensive (systolic blood pressure \\[SBP\\]\\\u003C130 and diastolic blood pressure \\[DBP\\] \\\u003C85 mmHg).\n* Have low density lipoprotein cholesterol \\\u003C150mg\u002Fdl.\n* Have HbA1C \\\u003C6.0%.\n\nExclusion Criteria:\n\n* Rash, skin disease, or disorders of pigmentation (e.g., psoriasis, eczema, vitiligo, or other skin inflammatory skin disorders)\n* Known skin allergies to latex or adhesives\n* Smoking and\u002For use of nicotine-containing products within the past year\n* Use of illegal\u002Frecreational drugs\n* Generalized kidney disease\n* Taking chloramphenicol, cholestyramine, medication for seizures, methotrexate, nitrofurantoin, tetracycline, barbiturates, steroids, phenobarbital\u002Fphenytoin, orlistat or pyrimethamine\n* Any current medications which could conceivably alter the cardiovascular control or responses\n* Diagnosed or suspected metabolic or cardiovascular disease\n* Current pregnancy or breastfeeding\n* History of skin or other cancers\n* Diagnosed or suspected diabetes (HbA1c ≥6.0)\n* Anybody with narcolepsy or who has been diagnosed with any condition that impairs body temperature regulation.",{"count":309,"type":22},60,[311],"PHASE2","Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and the non-Hispanic Black (NHB) population is disproportionately affected. Our research has previously demonstrated that oxidative stress may contribute to reduced vascular function in otherwise healthy NHB adults, potentially predisposing them to the development of hypertension and CVD. This study is designed to examine whether the mitochondria are an important source of oxidative stress-induced vascular dysfunction in healthy NHB adults.",[314],"Healthy",[316,317,318,319,320],"Vascular dysfunction","Cardiovascular disease","Hypertension","Nitric oxide","Endothelial function","2024-12-04",{"date":323,"type":35},"2024-12-09",{"date":325,"type":35},"2024-07-01",{"date":327,"type":22},"2030-03-31",{"name":41,"class":42},{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":16,"sex":17,"minAge":337,"maxAge":338,"enrollmentInfo":339,"targetDuration":4,"studyType":23,"phases":341,"briefSummary":342,"conditions":343,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":43},"100458716","health-and-resilience-projects-foundations-100458716","NCT05253235","Health and Resilience Projects: Foundations","Can Family-Centered Prevention Programming Reduce Neuroimmune Vulnerabilities for Drug Use and Cardiometabolic Risk Among African American Adolescents? A Randomized Prevention Trial","HARP-F","Inclusion Criteria:\n\nYouth:\n\n* Self reported African American or Black;\n* Age 10-13\n\nParents:\n\n* Primary caregiver for youth,\n* Resides in same household as youth.\n\nExclusion Criteria:\n\nYouth :\n\n* Contraindications for MRI scanning (e.g., metal in body, traumatic brain injury, claustrophobia, pregnancy),\n* Youth with chronic illnesses or medication regimens that would affect inflammatory panels (e.g., diabetes, congenital heart disease, asthma, cancers).\n\nParent:\n\n* Conditions (e.g., severe disability, psychoses) that would prevent participation in the SAAF intervention or completing self-report measures.","10 Years","13 Years",{"count":340,"type":22},650,[25],"The Health and Resilience Project (HARP): Foundations is investigating the efficacy of the Strong African American Families (SAAF) intervention in promoting the health and well being of African American adolescents. Youth age 10-13 and their primary caregivers are randomly assigned to receive SAAF or to a control group. Participants complete baseline and follow-up measures regarding vulnerability to substance use based on a neuroimmune model of stress coping.",[344],"Substance Use","2022-02-14",{"date":347,"type":35},"2022-02-23",{"date":349,"type":35},"2022-01-25",{"date":351,"type":22},"2027-12-31",{"name":41,"class":42},""]